Ku70, YPF1, DmKu70, YPF1β, Ku
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Multiphase exon postulated: exon reading frame differs in alternative transcripts.
None of the polypeptides share 100% sequence identity.
Heterodimer of a 70 kDa and a 80 kDa subunit.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Irbp using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Irbp in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Irbp Ypf1b
It had previously been suggested that mus309 corresponds to Irbp (FBrf0086898). Detailed deletion mapping suggests that this was incorrect and mus309 actually corresponds to blm, which is supported by the identification of mutations in the blm coding sequence for two mus309 alleles.
Identity of "Irbp" to "Ypf1b" based on DNA sequence identity.
mus309 stated to correspond to Irbp. Subsequent information suggests that this is not the case (see Kusano et al., 2001, Science 291(5513): 2600--2602).
A decrease in Irbp gene dosage causes a sharp increase in the frequency of HeT-A and TART-element attachments to a broken chromosome end and strongly enhances terminal DNA elongation by gene conversion. However, reduction in Irbp function also reduces the stability of terminally deficient chromosomes.
Irbp gene product specifically interacts with the outer half of the 31bp terminal inverted repeats.
Isolated from an ovarian cDNA expression library.