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Gene Dmel\Irbp

General Information
Symbol	Dmel\Irbp	Species	D. melanogaster
Name	Inverted repeat-binding protein	Annotation symbol	CG5247
Feature type	protein_coding_gene	FlyBase ID	FBgn0011774
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	Ku70, YPF1, DmKu70, Ku, YPF1β
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	86E4-86E4	Sequence location	3R:7,235,770..7,238,162 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Inverted repeat-binding protein is referred to in FlyBase by the symbol Dmel\Irbp (CG5247, FBgn0011774). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein heterodimerization activity; DNA binding. There is experimental evidence that it is involved in the biological process: telomere maintenance. 13 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA helicase, ATP-dependent, Ku type; DNA helicase, ATP-dependent, Ku70 subunit; Ku70/Ku80 C-terminal arm; Ku70/Ku80, N-terminal alpha/beta; Spen Paralogue and Orthologue SPOC, C-terminal-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1640431_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Irbp. Gene sequence location is 3R:7235770..7238162.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	References Chiolo et al., 2011, Cell 144(5): 732--744 Sequence features HFA17007 BKN21498
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 86E4-86E4   Limits computationally determined from genome sequence between P{EP}EP3340EP3340 and P{PZ}tho1&P{PZ}l(3)0462905275
Experimentally Determined Cytological Location
Cytogenetic map Notes References 34C-34C     (Jacoby, 1994.1.14) 86E2-86E3     (Beall, 1994.9.22) 86E2-86E3   (determined by in situ hybridisation)   (Beall et al., 1994) 34C-34C   (determined by in situ hybridisation)   (Jacoby and Wensink, 1994)   Not 34C1--34C7 as reported in FBrf0068542.   (Burtis, 1998.1.13)
Experimentally Determined Recombination Data
Location	3- (Beall, 1994.9.22)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Irbp for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Irbp-RA FBtr0082385  NM_080512   2148   631
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Irbp-PA   FBpp0081861   72.5   631   6.66     NP_536773   AAF54631
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ku70/Ku80 C-terminal arm (IPR005160) Ku70/Ku80, N-terminal alpha/beta (IPR005161) DNA helicase, ATP-dependent, Ku type (IPR006164) DNA helicase, ATP-dependent, Ku70 subunit (IPR006165) Spen Paralogue and Orthologue SPOC, C-terminal-like (IPR016194)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF54631   AY071244 AAL48866   BI232462   BI240757   BI367059   BP543969   BP543970   BT044080   CO284298   CO304490   CO313937   CO324163   CO330749   EC062637   EC212052   EC214110   EC237303   EC246645   EC247941   GH751091   GH753940   GH760674   GH774130   GH776222   GH782459   GH785882   GH786646   GH786713   GH789924   GH790654   GH793325   GH799215   GH801536   GH801581   GH802549   GH803344   GH811690   GH814771   GH819939   GH823943   GH831903   GH833289   GH838365   GH841850   GH841892   GH842128   GH845888   GH848104   GH856543   GH858701   GH859434   GH865404   GH871776   GH871781   GH873506   GH874777   GH876185   GH877404   GH878677   GH879126   GH885278   GH891166   GH892396   GH893503   GH901459   GH902494   GH910130   GH918709   GH918959   GH919750   GH927899   GH936350   U05208 AAA20644   U15004 AAC46492
UniProtKB/Swiss-Prot	Q23976
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0011774    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0011774 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0011774 expression level Developmental Stage   Expression Level embryo 00-02hr    4037 embryo 02-04hr    609 embryo 04-06hr    882 embryo 06-08hr    698 embryo 08-10hr    508 embryo 10-12hr    270 embryo 12-14hr    171 embryo 14-16hr    217 embryo 16-18hr    192 embryo 18-20hr    140 embryo 20-22hr    186 embryo 22-24hr    209 larva L1    321 larva L2    323 larva L3 12hr old    259 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    326 larva L3 puffstage 7-9    309 white prepupae new    242 white prepupae 12hr    325 white prepupae 24hr    298 pupae 2d postWPP    180 pupae 3d postWPP    107 pupae 4d postWPP    129 adult male 01day    218 adult male 05day    302 adult male 30day    406 adult female 01day    956 adult female 05day    2113 adult female 30day    2230 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4037) embryo 02-04hr  (609) embryo 04-06hr  (882) embryo 06-08hr  (698) embryo 08-10hr  (508) embryo 10-12hr  (270) embryo 12-14hr  (171) embryo 14-16hr  (217) embryo 16-18hr  (192) embryo 18-20hr  (140) embryo 20-22hr  (186) embryo 22-24hr  (209) larva L1  (321) larva L2  (323) larva L3 12hr old  (259) larva L3 puffstage 1-2  (298) larva L3 puffstage 3-6  (326) larva L3 puffstage 7-9  (309) white prepupae new  (242) white prepupae 12hr  (325) white prepupae 24hr  (298) pupae 2d postWPP  (180) pupae 3d postWPP  107 pupae 4d postWPP  (129) adult male 01day  (218) adult male 05day  (302) adult male 30day  (406) adult female 01day  (956) adult female 05day  (2113) adult female 30day  (2230) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4037) embryo 02-04hr    609 embryo 04-06hr    882 embryo 06-08hr    698 embryo 08-10hr    508 embryo 10-12hr    270 embryo 12-14hr    171 embryo 14-16hr    217 embryo 16-18hr    192 embryo 18-20hr    140 embryo 20-22hr    186 embryo 22-24hr    209 larva L1    321 larva L2    323 larva L3 12hr old    259 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    326 larva L3 puffstage 7-9    309 white prepupae new    242 white prepupae 12hr    325 white prepupae 24hr    298 pupae 2d postWPP    180 pupae 3d postWPP    107 pupae 4d postWPP    129 adult male 01day    218 adult male 05day    302 adult male 30day    406 adult female 01day    956 adult female 05day  (2113) adult female 30day  (2230) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4037 embryo 02-04hr    609 embryo 04-06hr    882 embryo 06-08hr    698 embryo 08-10hr    508 embryo 10-12hr    270 embryo 12-14hr    171 embryo 14-16hr    217 embryo 16-18hr    192 embryo 18-20hr    140 embryo 20-22hr    186 embryo 22-24hr    209 larva L1    321 larva L2    323 larva L3 12hr old    259 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    326 larva L3 puffstage 7-9    309 white prepupae new    242 white prepupae 12hr    325 white prepupae 24hr    298 pupae 2d postWPP    180 pupae 3d postWPP    107 pupae 4d postWPP    129 adult male 01day    218 adult male 05day    302 adult male 30day    406 adult female 01day    956 adult female 05day    2113 adult female 30day    2230 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4037 embryo 02-04hr    609 embryo 04-06hr    882 embryo 06-08hr    698 embryo 08-10hr    508 embryo 10-12hr    270 embryo 12-14hr    171 embryo 14-16hr    217 embryo 16-18hr    192 embryo 18-20hr    140 embryo 20-22hr    186 embryo 22-24hr    209 larva L1    321 larva L2    323 larva L3 12hr old    259 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    326 larva L3 puffstage 7-9    309 white prepupae new    242 white prepupae 12hr    325 white prepupae 24hr    298 pupae 2d postWPP    180 pupae 3d postWPP    107 pupae 4d postWPP    129 adult male 01day    218 adult male 05day    302 adult male 30day    406 adult female 01day    956 adult female 05day    2113 adult female 30day    2230 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0011774 expression level Developmental Stage   Expression Level embryo 00-02hr    4037 embryo 02-04hr    609 embryo 04-06hr    882 embryo 06-08hr    698 embryo 08-10hr    508 embryo 10-12hr    270 embryo 12-14hr    171 embryo 14-16hr    217 embryo 16-18hr    192 embryo 18-20hr    140 embryo 20-22hr    186 embryo 22-24hr    209 larva L1    321 larva L2    323 larva L3 12hr old    259 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    326 larva L3 puffstage 7-9    309 white prepupae new    242 white prepupae 12hr    325 white prepupae 24hr    298 pupae 2d postWPP    180 pupae 3d postWPP    107 pupae 4d postWPP    129 adult male 01day    218 adult male 05day    302 adult male 30day    406 adult female 01day    956 adult female 05day    2113 adult female 30day    2230 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4037) embryo 02-04hr  (609) embryo 04-06hr  (882) embryo 06-08hr  (698) embryo 08-10hr  (508) embryo 10-12hr  (270) embryo 12-14hr  (171) embryo 14-16hr  (217) embryo 16-18hr  (192) embryo 18-20hr  140 embryo 20-22hr  (186) embryo 22-24hr  (209) larva L1  (321) larva L2  (323) larva L3 12hr old  (259) larva L3 puffstage 1-2  (298) larva L3 puffstage 3-6  (326) larva L3 puffstage 7-9  (309) white prepupae new  (242) white prepupae 12hr  (325) white prepupae 24hr  (298) pupae 2d postWPP  (180) pupae 3d postWPP  107 pupae 4d postWPP  129 adult male 01day  (218) adult male 05day  (302) adult male 30day  (406) adult female 01day  (956) adult female 05day  (2113) adult female 30day  (2230) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4037) embryo 02-04hr    609 embryo 04-06hr    882 embryo 06-08hr    698 embryo 08-10hr    508 embryo 10-12hr    270 embryo 12-14hr    171 embryo 14-16hr    217 embryo 16-18hr    192 embryo 18-20hr    140 embryo 20-22hr    186 embryo 22-24hr    209 larva L1    321 larva L2    323 larva L3 12hr old    259 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    326 larva L3 puffstage 7-9    309 white prepupae new    242 white prepupae 12hr    325 white prepupae 24hr    298 pupae 2d postWPP    180 pupae 3d postWPP    107 pupae 4d postWPP    129 adult male 01day    218 adult male 05day    302 adult male 30day    406 adult female 01day    956 adult female 05day  2113 adult female 30day  2230 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4037 embryo 02-04hr    609 embryo 04-06hr    882 embryo 06-08hr    698 embryo 08-10hr    508 embryo 10-12hr    270 embryo 12-14hr    171 embryo 14-16hr    217 embryo 16-18hr    192 embryo 18-20hr    140 embryo 20-22hr    186 embryo 22-24hr    209 larva L1    321 larva L2    323 larva L3 12hr old    259 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    326 larva L3 puffstage 7-9    309 white prepupae new    242 white prepupae 12hr    325 white prepupae 24hr    298 pupae 2d postWPP    180 pupae 3d postWPP    107 pupae 4d postWPP    129 adult male 01day    218 adult male 05day    302 adult male 30day    406 adult female 01day    956 adult female 05day    2113 adult female 30day    2230 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4037 embryo 02-04hr    609 embryo 04-06hr    882 embryo 06-08hr    698 embryo 08-10hr    508 embryo 10-12hr    270 embryo 12-14hr    171 embryo 14-16hr    217 embryo 16-18hr    192 embryo 18-20hr    140 embryo 20-22hr    186 embryo 22-24hr    209 larva L1    321 larva L2    323 larva L3 12hr old    259 larva L3 puffstage 1-2    298 larva L3 puffstage 3-6    326 larva L3 puffstage 7-9    309 white prepupae new    242 white prepupae 12hr    325 white prepupae 24hr    298 pupae 2d postWPP    180 pupae 3d postWPP    107 pupae 4d postWPP    129 adult male 01day    218 adult male 05day    302 adult male 30day    406 adult female 01day    956 adult female 05day    2113 adult female 30day    2230 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0011774    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0011774 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0011774 expression level Tissue   Expression Level Larval Central Nervous System    65.975 Larval Midgut    31.5 Larval Hindgut    39.4 Larval Malpighian Tubules    59.2 Larval Fat Body    18.5 Larval Salivary Gland    39.8 Larval Trachea    64.075 Larval Carcass    37.175 Adult Head    34.5 Adult Eye    34.1 Adult Brain    32.8 Adult Thoracic-Abdominal Ganglion    50.9 Adult Crop    38.1 Adult Midgut    51.2 Adult Hindgut    38.9 Adult Malpighian Tubules    72.6 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.9 Adult Testis no informative data Adult Male Accessory Gland    40 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    65.975 Larval Midgut    31.5 Larval Hindgut    39.4 Larval Malpighian Tubules    59.2 Larval Fat Body    18.5 Larval Salivary Gland    39.8 Larval Trachea    64.075 Larval Carcass    37.175 Adult Head    34.5 Adult Eye    34.1 Adult Brain    32.8 Adult Thoracic-Abdominal Ganglion    50.9 Adult Crop    38.1 Adult Midgut    51.2 Adult Hindgut    38.9 Adult Malpighian Tubules    72.6 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.9 Adult Testis no informative data Adult Male Accessory Gland    40 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    65.975 Larval Midgut    31.5 Larval Hindgut    39.4 Larval Malpighian Tubules    59.2 Larval Fat Body    18.5 Larval Salivary Gland    39.8 Larval Trachea    64.075 Larval Carcass    37.175 Adult Head    34.5 Adult Eye    34.1 Adult Brain    32.8 Adult Thoracic-Abdominal Ganglion    50.9 Adult Crop    38.1 Adult Midgut    51.2 Adult Hindgut    38.9 Adult Malpighian Tubules    72.6 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.9 Adult Testis no informative data Adult Male Accessory Gland    40 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    65.975 Larval Midgut    31.5 Larval Hindgut    39.4 Larval Malpighian Tubules    59.2 Larval Fat Body    18.5 Larval Salivary Gland    39.8 Larval Trachea    64.075 Larval Carcass    37.175 Adult Head    34.5 Adult Eye    34.1 Adult Brain    32.8 Adult Thoracic-Abdominal Ganglion    50.9 Adult Crop    38.1 Adult Midgut    51.2 Adult Hindgut    38.9 Adult Malpighian Tubules    72.6 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.9 Adult Testis no informative data Adult Male Accessory Gland    40 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0011774 expression level Tissue   Expression Level Larval Central Nervous System    65.975 Larval Midgut    31.5 Larval Hindgut    39.4 Larval Malpighian Tubules    59.2 Larval Fat Body    18.5 Larval Salivary Gland    39.8 Larval Trachea    64.075 Larval Carcass    37.175 Adult Head    34.5 Adult Eye    34.1 Adult Brain    32.8 Adult Thoracic-Abdominal Ganglion    50.9 Adult Crop    38.1 Adult Midgut    51.2 Adult Hindgut    38.9 Adult Malpighian Tubules    72.6 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.9 Adult Testis no informative data Adult Male Accessory Gland    40 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    65.975 Larval Midgut    31.5 Larval Hindgut    39.4 Larval Malpighian Tubules    59.2 Larval Fat Body    18.5 Larval Salivary Gland    39.8 Larval Trachea    64.075 Larval Carcass    37.175 Adult Head    34.5 Adult Eye    34.1 Adult Brain    32.8 Adult Thoracic-Abdominal Ganglion    50.9 Adult Crop    38.1 Adult Midgut    51.2 Adult Hindgut    38.9 Adult Malpighian Tubules    72.6 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.9 Adult Testis no informative data Adult Male Accessory Gland    40 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    65.975 Larval Midgut    31.5 Larval Hindgut    39.4 Larval Malpighian Tubules    59.2 Larval Fat Body    18.5 Larval Salivary Gland    39.8 Larval Trachea    64.075 Larval Carcass    37.175 Adult Head    34.5 Adult Eye    34.1 Adult Brain    32.8 Adult Thoracic-Abdominal Ganglion    50.9 Adult Crop    38.1 Adult Midgut    51.2 Adult Hindgut    38.9 Adult Malpighian Tubules    72.6 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.9 Adult Testis no informative data Adult Male Accessory Gland    40 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    65.975 Larval Midgut    31.5 Larval Hindgut    39.4 Larval Malpighian Tubules    59.2 Larval Fat Body    18.5 Larval Salivary Gland    39.8 Larval Trachea    64.075 Larval Carcass    37.175 Adult Head    34.5 Adult Eye    34.1 Adult Brain    32.8 Adult Thoracic-Abdominal Ganglion    50.9 Adult Crop    38.1 Adult Midgut    51.2 Adult Hindgut    38.9 Adult Malpighian Tubules    72.6 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    34.175 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    268.9 Adult Testis no informative data Adult Male Accessory Gland    40 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis no informative data Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    34.5   NA  Eye    34.1   NA  Brain    32.8   65.975  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    50.9   NA  Crop    38.1   31.5  Midgut    51.2   39.4  Hindgut    38.9   59.2  Malpighian Tubules    72.6   18.5  Fat Body    no informative data   39.8  Salivary Gland    no informative data   NA  Heart    34.175   64.075  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    268.9   NA  Testis    no informative data   NA  Male Accessory Gland    40   37.175  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_13
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011774 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5247-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 IrbpGD4578 Other Phenotypes Allele chemical sensitive | recessive IrbpEX8 radiation sensitive | recessive IrbpEX8 visible | recessive IrbpEX8 wild-type Irbp+t8.8 Irbp+t13 Phenotype manifest in Allele adult thoracic sensillum | supernumerary IrbpEX8 macrochaeta | supernumerary IrbpEX8
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Irbp Class Mutagen Stocks Known lesion Irbp7B2 P-element activity 0 Yes IrbpEX8 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Irbp Class Mutagen Stocks Known lesion IrbpGD4578 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes IrbpGL00286 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes IrbpJF03273 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Irbp+t13 in vitro construct - genomic fragment 0 Yes Irbp+t8.8 in vitro construct - genomic fragment 0 Yes Irbp6.8 in vitro construct - genomic fragment 0 Yes IrbpAct5C.PB in vitro construct - regulatory fusion 0 Yes IrbpdsRNA.cMa in vitro construct - RNAi 0 Yes Irbphs.PR in vitro construct - regulatory fusion 0 Yes IrbpKK101447 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes IrbpΔ in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6160 (Ryder, 2004.4.26) Df(3R)Exel7308 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-Irbp.R} NA UAS construct P{GD4578} NA P{KK101447} NA P{TRiP.GL00286} NA P{TRiP.JF03273} NA characterization construct P{gIRBP6.8} NA P{gIRBP8.8} NA P{gIRBP13} NA P{gIRBPΔ} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
contributes_to DNA binding inferred from direct assay (Jacoby and Wensink, 1996) DNA binding inferred from direct assay (Jacoby and Wensink, 1994) inferred from direct assay AND inferred from sequence or structural similarity with human XRCC6 (Beall et al., 1994) protein heterodimerization activity inferred from direct assay (Jacoby and Wensink, 1994)
Biological Process
CV term Evidence References
telomere maintenance inferred from mutant phenotype (Melnikova et al., 2005)
Cellular Component
CV term Evidence References
Ku70:Ku80 complex inferred from direct assay (Jacoby and Wensink, 1994)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
ATP-dependent DNA helicase activity inferred from electronic annotation with InterPro:IPR005160, InterPro:IPR006164, InterPro:IPR006165 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 2000.5.30) DNA binding non-traceable author statement (Beall, 1994.9.22, Jacoby, 1994.1.14) DNA-dependent protein kinase activity non-traceable author statement (Jacoby, 1994.1.14)
Biological Process
CV term Evidence References
double-strand break repair via nonhomologous end joining inferred from electronic annotation with InterPro:IPR005160, InterPro:IPR006164, InterPro:IPR006165 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
DNA-dependent protein kinase-DNA ligase 4 complex inferred from electronic annotation with InterPro:IPR006165 (FlyBase Curators et al., 2004-) nucleus non-traceable author statement (Beall, 1994.9.22, Swiss-Prot Project Members, 2000.5.30)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Irbp allele Gene References Irbp+t8.8 mus309 (Beall and Rio, 1996, Kusano et al., 2001) Irbp+t13 mus309 (Beall and Rio, 1996)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72892 DroID - A comprehensive database of gene and protein interactions. • FBgn0011774 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 117419
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16859 Dere\GG18111 Dgri\GH18304 Dmoj\GI24114 Dper\GL12608 Dpse\GA18760 Dsec\GM23941 Dsim\GD18751 Dvir\GJ10937 Dwil\GK11797 Dyak\GE26092
Curated drosophilid orthologs	Dpse\GA18760   Dsim\Irbp (Anderson et al., 2009)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP002690-PA Anopheles gambiae (mosquito) XP_625058.2 Apis mellifera (honey bee) XP_001952755.1 Acyrthosiphon pisum (pea aphid) At1g16970.1 Arabidopsis thaliana (wall cress) 36232 Batrachochytrium dendrobatidis (chytrid fungus) 280446 Branchiostoma floridae (lancelet) 281658 Branchiostoma floridae (lancelet) XP_001899743.1 Brugia malayi (roundworm nematode) BGIBMGA004019-PA Bombyx mori (silk worm) ENSBTAP00000008020 Bos taurus (bovine) CE28984 Caenorhabditis elegans (worm) ENSCAFP00000001473 Canis familiaris (dog) ENSCINP00000001163 Ciona intestinalis (sea squirt) JA07176 Caenorhabditis japonica (nematode) cn08350 Cryptococcus neoformans (yeast-like fungus) CPIJ002893 Culex pipens (mosquito) ENSCPOP00000003202 Cavia porcellus (guinea pig) RP19505 Caenorhabditis remanei (nematode) 158558 Capitella spl (polychaete worm) DDB0232001 Dictyostelium discoideum (amoeba) 40467 Daphnia pulex (daphnia) ENSDARP00000096636 Danio rerio (zebra fish) ENSECAP00000015554 Equus caballus (horse) ENSGACP00000006455 Gymnopilus aculeatus (mushroom) ENSGALP00000037185 Gallus gallus (chicken) 192857 Hypsipyla robusta (cedar shoot borer) ENSP00000353192 Homo sapiens (human) ISCW021768-PA Ixodes scapularis (deer tick) 182021 Lottia gigantea (owl limpet) LmjF29.1050 Leishmania major (virus) ENSMODP00000020709 Monodelphis domestica (gray opossum) ENSMMUP00000036966 Macaca mulatta (rhesus monkey) ENSMUSP00000068559 Mus musculus (house mouse) 238226 Nematostella vectensis (starlet anemone) XP_001606141.1 Nasonia vitripennis (wasp) ENSOANP00000017950 Ornithorynchus anatinus (platypus) ENSORLP00000003026 Oryzias latipes (japanese killifish) LOC_Os07g08729.1 Oryza sativa (asian rice) 34459 Ostreococcus tauri (green alga) PHUM010826-PA Pediculus humanus (human body louse) PP08590 Pristionchus pacificus (nematode) 60909 Physcomitrella patens (moss) ENSPPYP00000013253 Pongo pygmaeus (orangutan) 235497 Populus trichocarpa (black cottonwood) ENSPTRP00000043206 Pan troglodytes (chimpanzee) ENSRNOP00000008819 Rattus norvegicus (norway rat) 5032669 Sorghum bicolor (sorghum) SPCC126.02c Schizosaccharomyces pombe (fission yeast) XP_001189673.1 Strongylocentrotus purpuratus (purple sea urchin) 61626 Trichoplax adhaerens (metazoa) XP_975296.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015927 Tetraodon nigroviridis (green spotted pufferfish) 263010 Thalassiosira pseudonana (marine diatom) ENSTRUP00000043728 Takifugu rubripes (pufferfish Takifugu) 3720.m00655 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000009877 Xenopus tropicalis (frog) YALI0C08701g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10568 NV14675 LH14159 ISCW021768 FBgn0243132 FBgn0213808 FBgn0198205 FBgn0190271 FBgn0178806 JGI_V11_40467 FBgn0078760 FBgn0150214 FBgn0146837 FBgn0125772 FBgn0110328 FBgn0093879 CPIJ002893 BGIBMGA004019 ACYPI007556 AGAP002690 PHUM543830 GLEAN_09971
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	29594 y1 v1; P{TRiP.JF03273}attP2 35819 y1 sc* v1; P{TRiP.GL00286}attP2
VDRC	v16758 w1118 P{GD4578}v16758
Genomic Clones ( 2 )
	BACR05C15 BACR13P08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 68 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE28533
Other clones	FI01513
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE37673 RE52733
Other clones	56524 64817 64820 98069 108366 EK165707 EK192854 EK234332 EK244843 EK296109 FGC023D04 RP003044260 RP003049777 RP003091145 RP003107756 RP003108023 RP003110252 RP003130189 RP003137500 RP003152587 RP003166230 RP003177123 RP003180581 RP003202089 RP003229383 RP003278829 RP003279888 RP003284028 RP003286372 RP003286436 RP003290756 RP003314878 RP003316044 RP003332713 RP003343409 RP003355094 RP003359447 RP003385603 RP003389498 RP003404039 RP003405273 RP003410900 RP003418761 RP003421117 RP003425725 RP003470676 RP003482403 RP003487398 RP003497160 RP003539931 RP003544988 RP003545071 RP003560464 RP003562936 RP003569605 RP003599510 RP003607577 RP003611525 RP003617465 RP003645417 RP003647404 RP003649181 RP003663173 RP003668737
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011774 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 117419
Antibody Information
	polyclonal (Chiolo et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Irbp Ypf1b (Burtis, 1998.1.13)
Additional comments	snoRNA:Irbp-a is encoded in an intron of Irbp. (Graveley et al., 2011) It had previously been suggested that mus309 corresponds to Irbp (FBrf0086898). Detailed deletion mapping suggests that this was incorrect and mus309 actually corresponds to blm, which is supported by the identification of mutations in the blm coding sequence for two mus309 alleles. (Kusano et al., 2001) Identity of "Irbp" to "Ypf1b" based on DNA sequence identity. (Burtis, 1998.1.13) mus309 stated to correspond to Irbp. Subsequent information suggests that this is not the case (see Kusano et al., 2001, Science 291(5513): 2600--2602). (Beall and Rio, 1996)
Other Comments
	Irbp has a role in length regulation of telomeres. (Melnikova et al., 2005) A decrease in Irbp gene dosage causes a sharp increase in the frequency of HeT-A and TART-element attachments to a broken chromosome end and strongly enhances terminal DNA elongation by gene conversion. However, reduction in Irbp function also reduces the stability of terminally deficient chromosomes. (Melnikova et al., 2005) The DNA binding properties of YPF1, a heterodimeric protein encoded by Ypf1a and Irbp, have been investigated. (Jacoby and Wensink, 1996) Irbp may act to preserve P-element ends when transposition produces a double strand gap. This allows the terminus to serve as a template upon which DNA synthesis can act to repair the gap. (Staveley et al., 1995) Irbp gene product specifically interacts with the outer half of the 31bp terminal inverted repeats. (Beall et al., 1994) Isolated from an ovarian cDNA expression library. (Jacoby and Wensink, 1994) Irbp has been cloned. The purified Irbp subunit binds DNA. (Jacoby and Wensink, 1994) The Irbp protein is a sequence-specific DNA-binding protein that has a high affinity for a 31bp sequence in the Yp1 gene necessary for normal steady state levels of Yp1 RNA in vivo. (Mitsis and Wensink, 1989) DNase I footprinting has identified a protein from Kc cells that binds to the P-element 31bp inverted repeats. UV photochemical crosslinking and purification of protein identifies the DNA binding activity within a polypeptide of 66kD. (Rio and Rubin, 1988)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080512 RefSeq (Proteins) • NP_536773 DDBJ / EMBL / GenBank • AAA20644 AAC46492 AAF54631 AAL48866 AY071244 BI232462 U05208 U15004 Entrez Gene - A searchable database of RefSeq genes. • 117419 UniProtKB/Swiss-Prot • Q23976
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ku70/Ku80 C-terminal arm (IPR005160) Ku70/Ku80, N-terminal alpha/beta (IPR005161) DNA helicase, ATP-dependent, Ku type (IPR006164) DNA helicase, ATP-dependent, Ku70 subunit (IPR006165) Spen Paralogue and Orthologue SPOC, C-terminal-like (IPR016194)
Linkouts
	BioGRID - A database of protein and genetic interactions • 72892 DroID - A comprehensive database of gene and protein interactions. • FBgn0011774 DRSC - Results from RNAi screens. • FBgn0011774 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011774 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5247-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011774 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 117419 InParanoid A subset of ortholog calls from InParanoid. • AGAP002690-PA Anopheles gambiae (mosquito) XP_625058.2 Apis mellifera (honey bee) XP_001952755.1 Acyrthosiphon pisum (pea aphid) At1g16970.1 Arabidopsis thaliana (wall cress) 36232 Batrachochytrium dendrobatidis (chytrid fungus) 280446 Branchiostoma floridae (lancelet) 281658 Branchiostoma floridae (lancelet) XP_001899743.1 Brugia malayi (roundworm nematode) BGIBMGA004019-PA Bombyx mori (silk worm) ENSBTAP00000008020 Bos taurus (bovine) CE28984 Caenorhabditis elegans (worm) ENSCAFP00000001473 Canis familiaris (dog) ENSCINP00000001163 Ciona intestinalis (sea squirt) JA07176 Caenorhabditis japonica (nematode) cn08350 Cryptococcus neoformans (yeast-like fungus) CPIJ002893 Culex pipens (mosquito) ENSCPOP00000003202 Cavia porcellus (guinea pig) RP19505 Caenorhabditis remanei (nematode) 158558 Capitella spl (polychaete worm) DDB0232001 Dictyostelium discoideum (amoeba) 40467 Daphnia pulex (daphnia) ENSDARP00000096636 Danio rerio (zebra fish) ENSECAP00000015554 Equus caballus (horse) ENSGACP00000006455 Gymnopilus aculeatus (mushroom) ENSGALP00000037185 Gallus gallus (chicken) 192857 Hypsipyla robusta (cedar shoot borer) ENSP00000353192 Homo sapiens (human) ISCW021768-PA Ixodes scapularis (deer tick) 182021 Lottia gigantea (owl limpet) LmjF29.1050 Leishmania major (virus) ENSMODP00000020709 Monodelphis domestica (gray opossum) ENSMMUP00000036966 Macaca mulatta (rhesus monkey) ENSMUSP00000068559 Mus musculus (house mouse) 238226 Nematostella vectensis (starlet anemone) XP_001606141.1 Nasonia vitripennis (wasp) ENSOANP00000017950 Ornithorynchus anatinus (platypus) ENSORLP00000003026 Oryzias latipes (japanese killifish) LOC_Os07g08729.1 Oryza sativa (asian rice) 34459 Ostreococcus tauri (green alga) PHUM010826-PA Pediculus humanus (human body louse) PP08590 Pristionchus pacificus (nematode) 60909 Physcomitrella patens (moss) ENSPPYP00000013253 Pongo pygmaeus (orangutan) 235497 Populus trichocarpa (black cottonwood) ENSPTRP00000043206 Pan troglodytes (chimpanzee) ENSRNOP00000008819 Rattus norvegicus (norway rat) 5032669 Sorghum bicolor (sorghum) SPCC126.02c Schizosaccharomyces pombe (fission yeast) XP_001189673.1 Strongylocentrotus purpuratus (purple sea urchin) 61626 Trichoplax adhaerens (metazoa) XP_975296.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015927 Tetraodon nigroviridis (green spotted pufferfish) 263010 Thalassiosira pseudonana (marine diatom) ENSTRUP00000043728 Takifugu rubripes (pufferfish Takifugu) 3720.m00655 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000009877 Xenopus tropicalis (frog) YALI0C08701g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 117419 modMine - Data generated by the modENCODE project. • FBgn0011774 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10568 NV14675 LH14159 ISCW021768 FBgn0243132 FBgn0213808 FBgn0198205 FBgn0190271 FBgn0178806 JGI_V11_40467 FBgn0078760 FBgn0150214 FBgn0146837 FBgn0125772 FBgn0110328 FBgn0093879 CPIJ002893 BGIBMGA004019 ACYPI007556 AGAP002690 PHUM543830 GLEAN_09971
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG5247 (Perkins et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) DmKu70 (Min et al., 2004, Kusano et al., 2001, Pastink and Lohman, 1999) dp70 (Beall, 1994.9.22) IRBP (Beall, 1994.9.22, Lankenau and Gloor, 1998, Burtis, 1998.1.13, Beall and Rio, 1996, Johnson-Schlitz and Engels, 1996) Irbp (Doheny et al., 2008) irbp (Graveley et al., 2011) IRBP/Ku70 (Sekelsky et al., 1998) Ku (Smith and Jackson, 1999, Hawley and Gilliland, 2006) Ku70 (Wang and Lin, 2005, Melnikova et al., 2005, Mason et al., 2004, Sutcliffe and Brehm, 2004, Melnikova et al., 2004, Vijg, 2002, Engels et al., 2003, Wu and Hickson, 2001, Sekelsky et al., 2000, Gloor et al., 2000, Dynan and Yoo, 1998, Saville and O'Brochta, 1998, Jin et al., 1997, Boutanaev et al., 2007, Brodsky et al., 2004, Akdemir et al., 2007, Anderson et al., 2009, Pastink et al., 2001) ku70 (Cenci et al., 2005, Yu and McVey, 2010, Johnson-Schlitz et al., 2007, Zhang et al., 2008) p70 (Ghosh, 1997) YPF1 (Jacoby, 1994.1.14, Jacoby and Wensink, 1996, Jacoby et al., 1991, Mitsis and Wensink, 1989, Mitsis and Wensink, 1989) Ypf1b   YPF1β (Ghosh, 1997, Jacoby and Wensink, 1994)
Name Synonym	Inverted repeat-binding protein (Stark et al., 2007) Yolk protein factor 1b
Secondary FlyBase IDs
	FBgn0004048 FBgn0011292
References ( 63 )
Generate a list of	All references relating to this gene ( 63 )
List References by type	Research paper  ( 27 ) Supplementary material  ( 3 ) Review  ( 11 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) Biography  ( 1 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Chiolo et al., 2011, Cell 144(5): 732--744 Double-Strand Breaks in Heterochromatin Move Outside of a Dynamic HP1a Domain to Complete Recombinational Repair. [FBrf0213146] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Yu and McVey, 2010, Nucleic Acids Res. 38(17): 5706--5717 Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions. [FBrf0211874] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...