Gene Dmel\BRWD3

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General Information

Symbol

Dmel\BRWD3

Species

D. melanogaster

Name

BRWD3

Annotation symbol

CG31132

Feature type

protein_coding_gene

FlyBase ID

FBgn0011785

Gene Model Status

Current

Stock availability

11 publicly available

Also Known As

dBRWD3, l(3)05842, CG6400

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

95F12-95F13

Sequence location

3R:20,144,722..20,154,341 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

The gene BRWD3 is referred to in FlyBase by the symbol Dmel\BRWD3 (CG31132, FBgn0011785). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: mitotic G2 DNA damage checkpoint; positive regulation of JAK-STAT cascade; phagocytosis, engulfment. 18 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Bromodomain; Bromodomain, conserved site; Quinonprotein alcohol dehydrogenase-like-superfamily; WD40 repeat; WD40 repeat, conserved site; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval hindgut, larval Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640098_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of BRWD3. Gene sequence location is 3R:20144722..20154341.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

95F12-95F13

Limits computationally determined from genome sequence between P{PZ}crb⁰⁷²⁰⁷&P{PZ}BRWD3⁰⁵⁸⁴² and P{EP}CycB3^EP3127

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

95F11-95F12

(determined by in situ hybridisation)

(Spradling et al., 1999)

95F11-95F12

95F14--15

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\BRWD3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Apparent introns not annotated: probable artifact due to repetitive sequence.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

BRWD3-RA

FBtr0084604

NM_170139

7244

2232

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

BRWD3-PA

FBpp0083988

248.7

2232

6.58

NP_732982

AAF56278

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

WD40/YVTN repeat-like-containing domain (IPR015943)

Bromodomain (IPR001487)

WD40 repeat (IPR001680)

Bromodomain, conserved site (IPR018359)

WD40-repeat-containing domain (IPR017986)

WD40 repeat, conserved site (IPR019775)

Quinonprotein alcohol dehydrogenase-like superfamily (IPR011047)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval hindgut, larval Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		370.675
Larval Midgut		71.8
Larval Hindgut		131.4
Larval Malpighian Tubules		107
Larval Fat Body		65
Larval Salivary Gland		158.5
Larval Trachea		113.375
Larval Carcass		118.2
Adult Head		72.1
Adult Eye		86.55
Adult Brain		181.2
Adult Thoracic-Abdominal Ganglion		124.4
Adult Crop		111.2
Adult Midgut		63.7
Adult Hindgut		91.1
Adult Malpighian Tubules		52.2
Adult Fat Body		84.2
Adult Salivary Gland		150.4
Adult Heart		77.45
Adult VirginFemale Spermatheca		51.2
Adult InseminatedFemale Spermatheca		62
Adult Ovary		431.3
Adult Testis		44.9
Adult Male Accessory Gland		162.4
Adult Carcass		101.1
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		370.675
Larval Midgut		71.8
Larval Hindgut		131.4
Larval Malpighian Tubules		107
Larval Fat Body		65
Larval Salivary Gland		158.5
Larval Trachea		113.375
Larval Carcass		118.2
Adult Head		72.1
Adult Eye		86.55
Adult Brain		181.2
Adult Thoracic-Abdominal Ganglion		124.4
Adult Crop		111.2
Adult Midgut		63.7
Adult Hindgut		91.1
Adult Malpighian Tubules		52.2
Adult Fat Body		84.2
Adult Salivary Gland		150.4
Adult Heart		77.45
Adult VirginFemale Spermatheca		51.2
Adult InseminatedFemale Spermatheca		62
Adult Ovary		431.3
Adult Testis		44.9
Adult Male Accessory Gland		162.4
Adult Carcass		101.1
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		370.675
Larval Midgut		71.8
Larval Hindgut		131.4
Larval Malpighian Tubules		107
Larval Fat Body		65
Larval Salivary Gland		158.5
Larval Trachea		113.375
Larval Carcass		118.2
Adult Head		72.1
Adult Eye		86.55
Adult Brain		181.2
Adult Thoracic-Abdominal Ganglion		124.4
Adult Crop		111.2
Adult Midgut		63.7
Adult Hindgut		91.1
Adult Malpighian Tubules		52.2
Adult Fat Body		84.2
Adult Salivary Gland		150.4
Adult Heart		77.45
Adult VirginFemale Spermatheca		51.2
Adult InseminatedFemale Spermatheca		62
Adult Ovary		431.3
Adult Testis		44.9
Adult Male Accessory Gland		162.4
Adult Carcass		101.1
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		370.675
Larval Midgut		71.8
Larval Hindgut		131.4
Larval Malpighian Tubules		107
Larval Fat Body		65
Larval Salivary Gland		158.5
Larval Trachea		113.375
Larval Carcass		118.2
Adult Head		72.1
Adult Eye		86.55
Adult Brain		181.2
Adult Thoracic-Abdominal Ganglion		124.4
Adult Crop		111.2
Adult Midgut		63.7
Adult Hindgut		91.1
Adult Malpighian Tubules		52.2
Adult Fat Body		84.2
Adult Salivary Gland		150.4
Adult Heart		77.45
Adult VirginFemale Spermatheca		51.2
Adult InseminatedFemale Spermatheca		62
Adult Ovary		431.3
Adult Testis		44.9
Adult Male Accessory Gland		162.4
Adult Carcass		101.1
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		370.675
Larval Midgut		71.8
Larval Hindgut		131.4
Larval Malpighian Tubules		107
Larval Fat Body		65
Larval Salivary Gland		158.5
Larval Trachea		113.375
Larval Carcass		118.2
Adult Head		72.1
Adult Eye		86.55
Adult Brain		181.2
Adult Thoracic-Abdominal Ganglion		124.4
Adult Crop		111.2
Adult Midgut		63.7
Adult Hindgut		91.1
Adult Malpighian Tubules		52.2
Adult Fat Body		84.2
Adult Salivary Gland		150.4
Adult Heart		77.45
Adult VirginFemale Spermatheca		51.2
Adult InseminatedFemale Spermatheca		62
Adult Ovary		431.3
Adult Testis		44.9
Adult Male Accessory Gland		162.4
Adult Carcass		101.1
Expression Level Scale		None Low Moderate High

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		370.675
Larval Midgut		71.8
Larval Hindgut		131.4
Larval Malpighian Tubules		107
Larval Fat Body		65
Larval Salivary Gland		158.5
Larval Trachea		113.375
Larval Carcass		118.2
Adult Head		72.1
Adult Eye		86.55
Adult Brain		181.2
Adult Thoracic-Abdominal Ganglion		124.4
Adult Crop		111.2
Adult Midgut		63.7
Adult Hindgut		91.1
Adult Malpighian Tubules		52.2
Adult Fat Body		84.2
Adult Salivary Gland		150.4
Adult Heart		77.45
Adult VirginFemale Spermatheca		51.2
Adult InseminatedFemale Spermatheca		62
Adult Ovary		431.3
Adult Testis		44.9
Adult Male Accessory Gland		162.4
Adult Carcass		101.1
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		370.675
Larval Midgut		71.8
Larval Hindgut		131.4
Larval Malpighian Tubules		107
Larval Fat Body		65
Larval Salivary Gland		158.5
Larval Trachea		113.375
Larval Carcass		118.2
Adult Head		72.1
Adult Eye		86.55
Adult Brain		181.2
Adult Thoracic-Abdominal Ganglion		124.4
Adult Crop		111.2
Adult Midgut		63.7
Adult Hindgut		91.1
Adult Malpighian Tubules		52.2
Adult Fat Body		84.2
Adult Salivary Gland		150.4
Adult Heart		77.45
Adult VirginFemale Spermatheca		51.2
Adult InseminatedFemale Spermatheca		62
Adult Ovary		431.3
Adult Testis		44.9
Adult Male Accessory Gland		162.4
Adult Carcass		101.1
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		370.675
Larval Midgut		71.8
Larval Hindgut		131.4
Larval Malpighian Tubules		107
Larval Fat Body		65
Larval Salivary Gland		158.5
Larval Trachea		113.375
Larval Carcass		118.2
Adult Head		72.1
Adult Eye		86.55
Adult Brain		181.2
Adult Thoracic-Abdominal Ganglion		124.4
Adult Crop		111.2
Adult Midgut		63.7
Adult Hindgut		91.1
Adult Malpighian Tubules		52.2
Adult Fat Body		84.2
Adult Salivary Gland		150.4
Adult Heart		77.45
Adult VirginFemale Spermatheca		51.2
Adult InseminatedFemale Spermatheca		62
Adult Ovary		431.3
Adult Testis		44.9
Adult Male Accessory Gland		162.4
Adult Carcass		101.1
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	72.1
NA	Eye	86.55
NA	Brain	181.2
370.675	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	124.4
NA	Crop	111.2
71.8	Midgut	63.7
131.4	Hindgut	91.1
107	Malpighian Tubules	52.2
65	Fat Body	84.2
158.5	Salivary Gland	150.4
NA	Heart	77.45
113.375	Trachea	NA
NA	VirginFemale Spermatheca	51.2
NA	InseminatedFemale Spermatheca	62
NA	Ovary	431.3
NA	Testis	44.9
NA	Male Accessory Gland	162.4
118.2	Carcass	101.1

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		22
central nervous system, larvae L3		31
central nervous system, pupae P8		16
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		7
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		9
head, mated 20-day male		10
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		6
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		7
fat body, pupae P8		9
carcass, larvae L3 wandering		17
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		6
ovary, virgin 4-day female		36
ovary, mated 4-day female		36
testis, mated 4-day male		6
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		22
central nervous system, larvae L3		(31)
central nervous system, pupae P8		16
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		7
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		9
head, mated 20-day male		10
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		6
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		7
fat body, pupae P8		9
carcass, larvae L3 wandering		17
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		6
ovary, virgin 4-day female		(36)
ovary, mated 4-day female		(36)
testis, mated 4-day male		6
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		22
central nervous system, larvae L3		31
central nervous system, pupae P8		16
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		7
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		9
head, mated 20-day male		10
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		6
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		7
fat body, pupae P8		9
carcass, larvae L3 wandering		17
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		6
ovary, virgin 4-day female		36
ovary, mated 4-day female		36
testis, mated 4-day male		6
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		22
central nervous system, larvae L3		31
central nervous system, pupae P8		16
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		7
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		9
head, mated 20-day male		10
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		6
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		7
fat body, pupae P8		9
carcass, larvae L3 wandering		17
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		6
ovary, virgin 4-day female		36
ovary, mated 4-day female		36
testis, mated 4-day male		6
accessory gland, mated 4-day male		4
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		22
central nervous system, larvae L3		31
central nervous system, pupae P8		16
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		7
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		9
head, mated 20-day male		10
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		6
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		7
fat body, pupae P8		9
carcass, larvae L3 wandering		17
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		6
ovary, virgin 4-day female		36
ovary, mated 4-day female		36
testis, mated 4-day male		6
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		22
central nervous system, larvae L3		31
central nervous system, pupae P8		16
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		7
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		9
head, mated 20-day male		10
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		6
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		7
fat body, pupae P8		9
carcass, larvae L3 wandering		17
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		6
ovary, virgin 4-day female		(36)
ovary, mated 4-day female		(36)
testis, mated 4-day male		6
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		22
central nervous system, larvae L3		31
central nervous system, pupae P8		16
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		7
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		9
head, mated 20-day male		10
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		6
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		7
fat body, pupae P8		9
carcass, larvae L3 wandering		17
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		6
ovary, virgin 4-day female		36
ovary, mated 4-day female		36
testis, mated 4-day male		6
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		22
central nervous system, larvae L3		31
central nervous system, pupae P8		16
head, virgin 1-day female		6
head, virgin 4-day female		6
head, virgin 20-day female		7
head, mated 1-day female		6
head, mated 4-day female		6
head, mated 20-day female		7
head, mated 1-day male		10
head, mated 4-day male		9
head, mated 20-day male		10
salivary gland, larvae L3 wandering		1
salivary gland, white prepupae		4
digestive system, larvae L3 wandering		5
digestive system, 1-day adult		4
digestive system, 4-day adult		6
digestive system, 20-day adult		6
fat body, larvae L3 wandering		3
fat body, white prepupae		7
fat body, pupae P8		9
carcass, larvae L3 wandering		17
carcass, 1-day adult		5
carcass, 4-day adult		6
carcass, 20-day adult		6
ovary, virgin 4-day female		36
ovary, mated 4-day female		36
testis, mated 4-day male		6
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		62
embryo 02-04hr		84
embryo 04-06hr		61
embryo 06-08hr		56
embryo 08-10hr		42
embryo 10-12hr		21
embryo 12-14hr		22
embryo 14-16hr		34
embryo 16-18hr		25
embryo 18-20hr		17
embryo 20-22hr		42
embryo 22-24hr		30
larva L1		11
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		17
white prepupae 12hr		21
white prepupae 24hr		23
pupae 2d postWPP		13
pupae 3d postWPP		8
pupae 4d postWPP		10
adult male 01day		8
adult male 05day		9
adult male 30day		9
adult female 01day		23
adult female 05day		36
adult female 30day		37
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(62)
embryo 02-04hr		(84)
embryo 04-06hr		(61)
embryo 06-08hr		(56)
embryo 08-10hr		(42)
embryo 10-12hr		21
embryo 12-14hr		22
embryo 14-16hr		(34)
embryo 16-18hr		25
embryo 18-20hr		17
embryo 20-22hr		(42)
embryo 22-24hr		(30)
larva L1		11
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		17
white prepupae 12hr		21
white prepupae 24hr		23
pupae 2d postWPP		13
pupae 3d postWPP		8
pupae 4d postWPP		10
adult male 01day		8
adult male 05day		9
adult male 30day		9
adult female 01day		23
adult female 05day		(36)
adult female 30day		(37)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		62
embryo 02-04hr		84
embryo 04-06hr		61
embryo 06-08hr		56
embryo 08-10hr		42
embryo 10-12hr		21
embryo 12-14hr		22
embryo 14-16hr		34
embryo 16-18hr		25
embryo 18-20hr		17
embryo 20-22hr		42
embryo 22-24hr		30
larva L1		11
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		17
white prepupae 12hr		21
white prepupae 24hr		23
pupae 2d postWPP		13
pupae 3d postWPP		8
pupae 4d postWPP		10
adult male 01day		8
adult male 05day		9
adult male 30day		9
adult female 01day		23
adult female 05day		36
adult female 30day		37
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		62
embryo 02-04hr		84
embryo 04-06hr		61
embryo 06-08hr		56
embryo 08-10hr		42
embryo 10-12hr		21
embryo 12-14hr		22
embryo 14-16hr		34
embryo 16-18hr		25
embryo 18-20hr		17
embryo 20-22hr		42
embryo 22-24hr		30
larva L1		11
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		17
white prepupae 12hr		21
white prepupae 24hr		23
pupae 2d postWPP		13
pupae 3d postWPP		8
pupae 4d postWPP		10
adult male 01day		8
adult male 05day		9
adult male 30day		9
adult female 01day		23
adult female 05day		36
adult female 30day		37
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		62
embryo 02-04hr		84
embryo 04-06hr		61
embryo 06-08hr		56
embryo 08-10hr		42
embryo 10-12hr		21
embryo 12-14hr		22
embryo 14-16hr		34
embryo 16-18hr		25
embryo 18-20hr		17
embryo 20-22hr		42
embryo 22-24hr		30
larva L1		11
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		17
white prepupae 12hr		21
white prepupae 24hr		23
pupae 2d postWPP		13
pupae 3d postWPP		8
pupae 4d postWPP		10
adult male 01day		8
adult male 05day		9
adult male 30day		9
adult female 01day		23
adult female 05day		36
adult female 30day		37
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(62)
embryo 02-04hr		(84)
embryo 04-06hr		(61)
embryo 06-08hr		(56)
embryo 08-10hr		(42)
embryo 10-12hr		21
embryo 12-14hr		22
embryo 14-16hr		(34)
embryo 16-18hr		25
embryo 18-20hr		17
embryo 20-22hr		(42)
embryo 22-24hr		30
larva L1		11
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		17
white prepupae 12hr		21
white prepupae 24hr		23
pupae 2d postWPP		13
pupae 3d postWPP		8
pupae 4d postWPP		10
adult male 01day		8
adult male 05day		9
adult male 30day		9
adult female 01day		23
adult female 05day		(36)
adult female 30day		(37)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		62
embryo 02-04hr		84
embryo 04-06hr		61
embryo 06-08hr		56
embryo 08-10hr		42
embryo 10-12hr		21
embryo 12-14hr		22
embryo 14-16hr		34
embryo 16-18hr		25
embryo 18-20hr		17
embryo 20-22hr		42
embryo 22-24hr		30
larva L1		11
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		17
white prepupae 12hr		21
white prepupae 24hr		23
pupae 2d postWPP		13
pupae 3d postWPP		8
pupae 4d postWPP		10
adult male 01day		8
adult male 05day		9
adult male 30day		9
adult female 01day		23
adult female 05day		36
adult female 30day		37
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		62
embryo 02-04hr		84
embryo 04-06hr		61
embryo 06-08hr		56
embryo 08-10hr		42
embryo 10-12hr		21
embryo 12-14hr		22
embryo 14-16hr		34
embryo 16-18hr		25
embryo 18-20hr		17
embryo 20-22hr		42
embryo 22-24hr		30
larva L1		11
larva L2		8
larva L3 12hr old		7
larva L3 puffstage 1-2		7
larva L3 puffstage 3-6		13
larva L3 puffstage 7-9		15
white prepupae new		17
white prepupae 12hr		21
white prepupae 24hr		23
pupae 2d postWPP		13
pupae 3d postWPP		8
pupae 4d postWPP		10
adult male 01day		8
adult male 05day		9
adult male 30day		9
adult female 01day		23
adult female 05day		36
adult female 30day		37
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		22
Schneider line 2 Sg4		11
embryonic 1182-4H		19
embryonic GM2		16
embryonic Kc167		15
embryonic S1		19
embryonic S3		16
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		18
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		10
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		9
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		20
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		13
ovary fGS/OSS		29
ovary OSC		19
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		22
Schneider line 2 Sg4		11
embryonic 1182-4H		19
embryonic GM2		16
embryonic Kc167		15
embryonic S1		19
embryonic S3		16
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		18
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		10
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		9
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		20
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		13
ovary fGS/OSS		(29)
ovary OSC		19
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		22
Schneider line 2 Sg4		11
embryonic 1182-4H		19
embryonic GM2		16
embryonic Kc167		15
embryonic S1		19
embryonic S3		16
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		18
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		10
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		9
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		20
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		13
ovary fGS/OSS		29
ovary OSC		19
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		22
Schneider line 2 Sg4		11
embryonic 1182-4H		19
embryonic GM2		16
embryonic Kc167		15
embryonic S1		19
embryonic S3		16
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		18
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		10
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		9
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		20
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		13
ovary fGS/OSS		29
ovary OSC		19
ovary OSS		15
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		22
Schneider line 2 Sg4		11
embryonic 1182-4H		19
embryonic GM2		16
embryonic Kc167		15
embryonic S1		19
embryonic S3		16
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		18
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		10
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		9
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		20
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		13
ovary fGS/OSS		29
ovary OSC		19
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		22
Schneider line 2 Sg4		11
embryonic 1182-4H		19
embryonic GM2		16
embryonic Kc167		15
embryonic S1		19
embryonic S3		16
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		18
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		10
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		9
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		20
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		13
ovary fGS/OSS		29
ovary OSC		19
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		22
Schneider line 2 Sg4		11
embryonic 1182-4H		19
embryonic GM2		16
embryonic Kc167		15
embryonic S1		19
embryonic S3		16
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		18
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		10
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		9
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		20
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		13
ovary fGS/OSS		29
ovary OSC		19
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		22
Schneider line 2 Sg4		11
embryonic 1182-4H		19
embryonic GM2		16
embryonic Kc167		15
embryonic S1		19
embryonic S3		16
leg disc CME L1		15
wing disc CME-W2		12
wing disc ML-DmD8		16
wing disc ML-DmD9		18
wing disc ML-DmD16-c3		18
wing disc ML-DmD21		10
wing disc ML-DmD32		15
haltere disc ML-DmD17-c3		26
eye-antennal disc ML-DmD11		18
antennal disc ML-DmD20-c5		9
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		20
CNS ML-DmBG2-c2		22
tumorous blood cells mbn2		13
ovary fGS/OSS		29
ovary OSC		19
ovary OSS		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		15
cold shock, 4-day adult		10
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		34
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		21
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		20
Paraquat 10 mM 48 hrs, 4-day adult		21
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		15
cold shock, 4-day adult		10
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		(34)
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		21
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		20
Paraquat 10 mM 48 hrs, 4-day adult		21
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		15
cold shock, 4-day adult		10
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		34
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		21
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		20
Paraquat 10 mM 48 hrs, 4-day adult		21
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		15
cold shock, 4-day adult		10
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		34
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		21
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		20
Paraquat 10 mM 48 hrs, 4-day adult		21
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		15
cold shock, 4-day adult		10
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		34
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		21
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		20
Paraquat 10 mM 48 hrs, 4-day adult		21
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		15
cold shock, 4-day adult		10
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		(34)
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		21
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		20
Paraquat 10 mM 48 hrs, 4-day adult		21
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		15
cold shock, 4-day adult		10
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		34
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		21
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		20
Paraquat 10 mM 48 hrs, 4-day adult		21
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		15
cold shock, 4-day adult		10
heat shock, 4-day adult		13
Cadmium 50 mM 6 hrs, larvae L3		3
Cadmium 50 mM 12 hrs, larvae L3		2
Cadmium 50 mM 48 hrs, 4-day adult		13
Cadmium 100 mM 48 hrs, 4-day adult		26
Copper 0.5 mM 12 hrs, larvae L3		4
Copper 15 mM 48 hrs, 4-day adult		11
Zinc 5 mM 12 hrs, larvae L3		5
Zinc 4.5 mM 48 hrs, 4-day adult		7
Ethanol 2.5% 3 hrs, larvae L3		34
Ethanol 5% 3 hrs, larvae L3		2
Ethanol 10% 3 hrs, larvae L3		2
Caffeine 1.5 mg/ml 4 hrs, larvae L3		3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		21
Caffeine 25 mg/ml 48 hrs, 4-day adult		12
Paraquat 5 mM 48 hrs, 4-day adult		20
Paraquat 10 mM 48 hrs, 4-day adult		21
Rotenone 2 μg 12 hrs, larvae L3		2
Rotenone 8 μg 12 hrs, larvae L3		3
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010, Graveley et al., 2011)

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0011785

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG31132-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal (with BRWD3^ram1)

BRWD3^s5349

lethal (with BRWD3^s5349)

BRWD3^ram1

lethal | pupal stage

BRWD3⁰⁶⁶⁵⁶

lethal | pupal stage, with Scer\GAL4^pnr-MD237

BRWD3^GD10174

lethal | recessive

lethal | second instar larval stage

lethal | second instar larval stage (with Df(3R)crb87-5)

BRWD3^s5349

partially lethal - majority die | first instar larval stage

BRWD3^s5349

partially lethal - majority die | first instar larval stage (with Df(3R)crb87-5)

BRWD3^s5349

partially lethal - majority die | third instar larval stage

BRWD3⁰⁶⁶⁵⁶

Other Phenotypes

Allele

visible | somatic clone

Phenotype manifest in

Allele

eye | somatic clone

eye disc & actin cytoskeleton | somatic clone

BRWD3^PX2

eye disc & nucleus | somatic clone

BRWD3^PX2

rhabdomere & eye disc & pupa

BRWD3^PX3

wing vein | ectopic

BRWD3^Δ10

Classical Alleles ( 16 )

For All Classical Alleles Show

Allele of BRWD3	Class	Mutagen	Stocks	Known lesion
BRWD3^s5349	amorphic allele - genetic evidence	P-element activity	1	--
BRWD3⁰⁵⁸⁴²		P-element activity	1	Yes
BRWD3^e00263		piggyBac transposase	1	--
BRWD3^f03026		piggyBac transposase	1	--
BRWD3^f03832		piggyBac transposase	1	--
BRWD3^NP5316			1	--
BRWD3^NP5467			1	--
BRWD3^PX1		Delta2-3	1	Yes
BRWD3⁰⁶⁶⁵⁶	hypomorphic allele - genetic evidence	P-element activity	0	--
BRWD3^d00567		P-element activity	0	--
BRWD3^P2R1-51		Delta2-3	0	Yes
BRWD3^PX2		Delta2-3	0	Yes
BRWD3^PX3	hypomorphic allele - genetic evidence	Delta2-3	0	Yes
BRWD3^ram1	hypomorphic allele - genetic evidence	ethyl methanesulfonate	0	--
BRWD3^S070701			0	--
BRWD3^Δ10		P-element activity	0	Yes

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of BRWD3	Class	Mutagen	Stocks	Known lesion
BRWD3^GD10174		in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
BRWD3^HMS00304		in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes

Aneuploid Aberrations

Disrupted in

Df(3R)crb87-4

(Spradling et al., 1999, Muller, 2005, BDGP Project Members, 1994-1999)

Df(3R)crb87-5

(Spradling et al., 1999, Muller, 2005, BDGP Project Members, 1994-1999)

Df(3R)Exel6199

(Ryder, 2004.4.26)

Df(3R)Exel8178

(Ryder, 2004.4.26)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD10174}

P{TRiP.HMS00304}

Insertions

Type of insertions

Name

Expression data

insertion of enhancer trap

P{lacW}BRWD3^s5349

P{lacW}BRWD3^S070701

P{PZ}BRWD3⁰⁵⁸⁴²

P{PZ}BRWD3⁰⁶⁶⁵⁶

miscellaneous insertions

PBac{RB}BRWD3^e00263

PBac{WH}BRWD3^f03026

PBac{WH}BRWD3^f03832

insertion of enhancer trap binary system

P{GawB}BRWD3^NP5316

P{GawB}BRWD3^NP5467

insertion of mobile activating element

P{XP}BRWD3^d00567

Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )

Terms Based on Experimental Evidence ( 3 terms )

Molecular Function ( 0 terms)

Biological Process

CV term

Evidence

References

mitotic G2 DNA damage checkpoint

inferred from genetic interaction with nbs

(Kondo and Perrimon, 2011)

phagocytosis, engulfment

inferred from mutant phenotype

(Stroschein-Stevenson et al., 2006)

positive regulation of JAK-STAT cascade

inferred from genetic interaction with os

(Muller et al., 2005)

Cellular Component ( 0 terms)

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

protein-protein

Interacting group

Assay

References

BRWD3 - CkIIα

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

(Mintseris et al., 2009.11.23, Guruharsha et al., 2011)

BRWD3 - CkIIβ

experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting

(Guruharsha et al., 2011, Mintseris et al., 2009.11.23)

BRWD3 - pic

experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting

(Guruharsha et al., 2011, Mintseris et al., 2009.11.23)

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

BRWD3 allele

Gene

References

BRWD3⁰⁵⁸⁴²

hop

(Muller et al., 2005)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

67826

DPiM - DPiM, Drosophila Protein interaction Map

•

FBgn0011785

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0011785

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

42898

SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores.

•

Q9VC96

Orthologs

OrthoDB Orthologs (56) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG67ST05

Dipteran inclusive ortholog search

EOG6D26Z0

Insect inclusive ortholog search

EOG6D7X1N

Arthropod inclusive ortholog search

EOG6NS1SD

Metazoa inclusive ortholog search

EOG6CP3HS

Orthologs in Drosophila Species (EOG67ST05)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA24385

Drosophila pseudoobscura pseudoobscura

Dpse\GA16032

Drosophila persimilis

Dper\GL21851

Drosophila willistoni

Dwil\GK13309

Drosophila virilis

Dvir\GJ23804

Drosophila mojavensis

Dmoj\GI10068

Drosophila mojavensis

Dmoj\GI11537

Drosophila grimshawi

Dgri\GH18810

Drosophila grimshawi

Dgri\GH17740

Orthologs in non-Drosophila Dipterans (EOG6D26Z0)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL006038

Anopheles gambiae

Malaria mosquito

Agam\AGAP002030

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ020009

Orthologs in non-Dipteran Insects (EOG6D7X1N)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB51542

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG004417

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH11474

Atta cephalotes

Leafcutter ant

Acep\ACEP23885

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO19968

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL12806

Linepithema humile

Argentine ant

Lhum\LH25134

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB22306

Solenopsis invicta

Red fire ant

Sinv\SINV17800

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI006140

Bombyx mori

Silkmoth

Bmor\BGIBMGA009575

Pediculus humanus

Human body louse

Phum\PHUM458990

Tribolium castaneum

Red flour beetle

Tcas\TC004357

Orthologs in non-Insect Arthropods (EOG6NS1SD)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\ATP6

Daphnia pulex

Water flea

Dpux\JGI_V11_200903

Ixodes scapularis

Deer tick

Isca\ISCW020971

Orthologs in non-Arthropod Metazoa (EOG6CP3HS)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_028888gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_019256gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_017747gn

Danio rerio

Zebrafish

Drer\OTTDARG00000030710

Danio rerio

Zebrafish

Drer\si:dkey-237j10.3

Danio rerio

Zebrafish

Drer\BX088654.1

Xenopus tropicalis

Western clawed frog

Xtro\ENSXETG00000031031

Xenopus tropicalis

Western clawed frog

Xtro\brwd1

Xenopus tropicalis

Western clawed frog

Xtro\phip

Xenopus tropicalis

Western clawed frog

Xtro\brwd3

Gallus gallus

Domestic chicken

Ggal\BRWD1

Gallus gallus

Domestic chicken

Ggal\BRWD3

Gallus gallus

Domestic chicken

Ggal\PHIP

Mus musculus

House mouse

Mmus\Brwd1

Mus musculus

House mouse

Mmus\Brwd3

Mus musculus

House mouse

Mmus\Phip

Rattus norvegicus

Norway rat

Rnor\Brwd1

Rattus norvegicus

Norway rat

Rnor\RGD1564964

Rattus norvegicus

Norway rat

Rnor\Brwd3

Homo sapiens

Human

Hsap\BRWD1

Homo sapiens

Human

Hsap\BRWD3

Homo sapiens

Human

Hsap\PHIP

Human Orthologs (3)

Gene

OMIM

HGNC

Hsap\BRWD1

Hsap\BRWD3

Hsap\PHIP

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA16032

Drosophila persimilis

Dper\GL21851

Drosophila willistoni

Dwil\GK13309

Drosophila virilis

Dvir\GJ23804

Drosophila mojavensis

Dmoj\GI10068

Drosophila grimshawi

Dgri\GH18810

Stocks & Reagents

Stocks Listed in FlyBase ( 11 )

Bloomington

35560

w^*; BRWD3^PX1/TM3, Ser¹

35824

w^*; P{neoFRT}82B P{lacW}BRWD3^s5349/TM2

12155

ry⁵⁰⁶ P{PZ}BRWD3⁰⁵⁸⁴²/TM3, Sb¹

33421

y¹ sc^* v¹; P{TRiP.HMS00304}attP2

113677

w^*; P{GawB}BRWD3^NP5316 / TM6, P{UAS-lacZ.UW23-1}UW23-1

105029

y^* w^*; P{GawB}BRWD3^NP5467 / TM6, P{UAS-lacZ.UW23-1}UW23-1

VDRC

v40209

w¹¹¹⁸; P{GD10174}v40209

v40208

w¹¹¹⁸; P{GD10174}v40208/TM3

Genomic Clones ( 1 )

BACR04E17

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 35 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

DPiM_LD40380

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

DRSC - Results from RNAi screens.

•

FBgn0011785

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

42898

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for identity of: BRWD3 CG31132

(Muller et al., 2005, Muller, 2005)

Source for database merge of

Source for merge of: CG6400 CG18670

(Muller, 2005, FlyBase, 1996-)

Source for merge of: CG31132 anon-WO0118547.520 anon-WO0118547.620

(FlyBase, 1996-)

Additional comments

Annotations CG18670, CG6400 merged as CG31132 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of CG31132 anon-WO0118547.520 anon-WO0118547.620 was sequence comparison (date:051113).

(FlyBase, 1996-)

Source for merge of CG6400 CG18670 was a shared cDNA (date:010720).

(FlyBase, 1996-)

Other Comments

S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

(Stroschein-Stevenson et al., 2006)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_170139

RefSeq (Proteins)

•

NP_732982

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

42898

UniProtKB/TrEMBL

•

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

WD40/YVTN repeat-like-containing domain (IPR015943)

Bromodomain (IPR001487)

WD40 repeat (IPR001680)

Bromodomain, conserved site (IPR018359)

WD40-repeat-containing domain (IPR017986)

WD40 repeat, conserved site (IPR019775)

Quinonprotein alcohol dehydrogenase-like superfamily (IPR011047)

Linkouts

BioGRID - A database of protein and genetic interactions

•

67826

DPiM - DPiM, Drosophila Protein interaction Map

•

FBgn0011785

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0011785

DRSC - Results from RNAi screens.

•

FBgn0011785

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0011785

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG31132-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0011785

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

42898

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

42898

modMine - Data generated by the modENCODE project.

•

FBgn0011785

SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores.

•

Q9VC96

Synonyms & Secondary IDs ( 12 )

Reported As

Symbol Synonym

anon-WO0118547.520

anon-WO0118547.620

BRWD3

(Pek and Kai, 2011, Wendler et al., 2010, Arbouzova and Zeidler, 2006, Kondo and Perrimon, 2011, Wasbrough et al., 2010, Link et al., 2007)

CG6400

(Stathopoulos et al., 2002, Li et al., 2007)

CG18670

(Mount, 2001.8.14, )

CG31132

(Muller, 2005, Muller et al., 2005, FlyBase, 1996-, Davies et al., 2001, Stroschein-Stevenson et al., 2006, Ni et al., 2010.12.1, Cammarato et al., 2011)

dBRWD3

(Muller, 2005, Muller et al., 2005, Muller et al., 2005)

l(3)05842

(Spradling et al., 1999, BDGP Project Members, 1994-1999, D'Costa et al., 2006)

l(3)s5349

ram

(D'Costa et al., 2006)

Name Synonym

BRWD3

(Cammarato et al., 2011)

lethal (3) 05842

ramshackle

(D'Costa et al., 2006)

Secondary FlyBase IDs

FBgn0011039
FBgn0039181
FBgn0040598
FBgn0051132
FBgn0061821
FBgn0061922

References ( 37 )

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All references relating to this gene ( 37 )

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Research paper ( 11 )
Supplementary material ( 8 )
Review ( 1 )
Personal communication to FlyBase ( 11 )
Abstract ( 1 )
FlyBase analysis ( 4 )
Patent ( 1 )

Recent research papers ( 4 )

Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134: Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342]
Bai et al., 2011, BMC Biol. 9: 54: Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration. [FBrf0216297]
Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1: A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700]
Pek and Kai, 2011, Proc. Natl. Acad. Sci. U.S.A. 108(29): 12007--12012: DEAD-box RNA helicase Belle/DDX3 and the RNA interference pathway promote mitotic chromosome segregation. [FBrf0214405]

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Recent reviews (0)

All reviews listed in FlyBase were published before 2011

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