General Information Symbol Dmel\ mRpL12Species D. melanogaster Name mitochondrial ribosomal protein L12 Annotation symbol CG5012 Feature type protein_coding_gene FlyBase ID FBgn0011787 Gene Model Status Current Stock availability 5 publicly
available Also Known As l(3)10534 Genomic Location Chromosome (arm) 3L Recombination map Cytogenetic map 66E5-66E5 Sequence location 3L:8,949,891..8,950,684 [+]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information The gene
mitochondrial ribosomal protein L12 is referred to in FlyBase by the symbol
Dmel\mRpL12 (CG5012, FBgn0011787). It is a protein_coding_gene from
Drosophila melanogaster . There is experimental evidence that it has the
molecular function : chromatin binding. There is experimental evidence that it is involved in the
biological process : cell growth; mitochondrion organization.
11 alleles are reported . The
phenotype of these alleles is annotated with: trichogen cell. It has
one annotated transcript and
one annotated polypeptide .
Protein features are: Ribosomal protein L12, mitochondrial; Ribosomal protein L7/L12, C-terminal; Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like; Ribosomal protein L7/L12, oligomerisation. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-06 hour embryonic stages, during early larval stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1631718_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mRpL12. Gene sequence location is
3L:8949891..8950684 .
User Contributed Data
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
66E2-66E3
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Gene model reviewed during 5.46
Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) Comments External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
- A database of annotated Dmel nuclear genes encoding mitochondrial proteins
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. External Data Linkouts Crossreferences Expression Data Transcript ExpressionComment: maternally deposited
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
349.425
Larval Midgut
233.3
Larval Hindgut
346.2
Larval Malpighian Tubules
79.3
Larval Fat Body
91.7
Larval Salivary Gland
324.3
Larval Trachea
317.9
Larval Carcass
275.8
Adult Head
187.9
Adult Eye
163.675
Adult Brain
333.4
Adult Thoracic-Abdominal Ganglion
310.8
Adult Crop
189
Adult Midgut
373.1
Adult Hindgut
268.2
Adult Malpighian Tubules
217.5
Adult Fat Body
233.2
Adult Salivary Gland
219.6
Adult Heart
211.55
Adult VirginFemale Spermatheca
129.4
Adult InseminatedFemale Spermatheca
138.1
Adult Ovary
660.4
Adult Testis
202.7
Adult Male Accessory Gland
188.5
Adult Carcass
186.7
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
349.425
Larval Midgut
233.3
Larval Hindgut
346.2
Larval Malpighian Tubules
79.3
Larval Fat Body
91.7
Larval Salivary Gland
324.3
Larval Trachea
317.9
Larval Carcass
275.8
Adult Head
187.9
Adult Eye
163.675
Adult Brain
333.4
Adult Thoracic-Abdominal Ganglion
310.8
Adult Crop
189
Adult Midgut
373.1
Adult Hindgut
268.2
Adult Malpighian Tubules
217.5
Adult Fat Body
233.2
Adult Salivary Gland
219.6
Adult Heart
211.55
Adult VirginFemale Spermatheca
129.4
Adult InseminatedFemale Spermatheca
138.1
Adult Ovary
(660.4)
Adult Testis
202.7
Adult Male Accessory Gland
188.5
Adult Carcass
186.7
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
349.425
Larval Midgut
233.3
Larval Hindgut
346.2
Larval Malpighian Tubules
79.3
Larval Fat Body
91.7
Larval Salivary Gland
324.3
Larval Trachea
317.9
Larval Carcass
275.8
Adult Head
187.9
Adult Eye
163.675
Adult Brain
333.4
Adult Thoracic-Abdominal Ganglion
310.8
Adult Crop
189
Adult Midgut
373.1
Adult Hindgut
268.2
Adult Malpighian Tubules
217.5
Adult Fat Body
233.2
Adult Salivary Gland
219.6
Adult Heart
211.55
Adult VirginFemale Spermatheca
129.4
Adult InseminatedFemale Spermatheca
138.1
Adult Ovary
660.4
Adult Testis
202.7
Adult Male Accessory Gland
188.5
Adult Carcass
186.7
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
349.425
Larval Midgut
233.3
Larval Hindgut
346.2
Larval Malpighian Tubules
79.3
Larval Fat Body
91.7
Larval Salivary Gland
324.3
Larval Trachea
317.9
Larval Carcass
275.8
Adult Head
187.9
Adult Eye
163.675
Adult Brain
333.4
Adult Thoracic-Abdominal Ganglion
310.8
Adult Crop
189
Adult Midgut
373.1
Adult Hindgut
268.2
Adult Malpighian Tubules
217.5
Adult Fat Body
233.2
Adult Salivary Gland
219.6
Adult Heart
211.55
Adult VirginFemale Spermatheca
129.4
Adult InseminatedFemale Spermatheca
138.1
Adult Ovary
660.4
Adult Testis
202.7
Adult Male Accessory Gland
188.5
Adult Carcass
186.7
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
349.425
Larval Midgut
233.3
Larval Hindgut
346.2
Larval Malpighian Tubules
79.3
Larval Fat Body
91.7
Larval Salivary Gland
324.3
Larval Trachea
317.9
Larval Carcass
275.8
Adult Head
187.9
Adult Eye
163.675
Adult Brain
333.4
Adult Thoracic-Abdominal Ganglion
310.8
Adult Crop
189
Adult Midgut
373.1
Adult Hindgut
268.2
Adult Malpighian Tubules
217.5
Adult Fat Body
233.2
Adult Salivary Gland
219.6
Adult Heart
211.55
Adult VirginFemale Spermatheca
129.4
Adult InseminatedFemale Spermatheca
138.1
Adult Ovary
660.4
Adult Testis
202.7
Adult Male Accessory Gland
188.5
Adult Carcass
186.7
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
349.425
Larval Midgut
233.3
Larval Hindgut
346.2
Larval Malpighian Tubules
79.3
Larval Fat Body
91.7
Larval Salivary Gland
324.3
Larval Trachea
317.9
Larval Carcass
275.8
Adult Head
187.9
Adult Eye
163.675
Adult Brain
333.4
Adult Thoracic-Abdominal Ganglion
310.8
Adult Crop
189
Adult Midgut
373.1
Adult Hindgut
268.2
Adult Malpighian Tubules
217.5
Adult Fat Body
233.2
Adult Salivary Gland
219.6
Adult Heart
211.55
Adult VirginFemale Spermatheca
129.4
Adult InseminatedFemale Spermatheca
138.1
Adult Ovary
660.4
Adult Testis
202.7
Adult Male Accessory Gland
188.5
Adult Carcass
186.7
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
349.425
Larval Midgut
233.3
Larval Hindgut
346.2
Larval Malpighian Tubules
79.3
Larval Fat Body
91.7
Larval Salivary Gland
324.3
Larval Trachea
317.9
Larval Carcass
275.8
Adult Head
187.9
Adult Eye
163.675
Adult Brain
333.4
Adult Thoracic-Abdominal Ganglion
310.8
Adult Crop
189
Adult Midgut
373.1
Adult Hindgut
268.2
Adult Malpighian Tubules
217.5
Adult Fat Body
233.2
Adult Salivary Gland
219.6
Adult Heart
211.55
Adult VirginFemale Spermatheca
129.4
Adult InseminatedFemale Spermatheca
138.1
Adult Ovary
660.4
Adult Testis
202.7
Adult Male Accessory Gland
188.5
Adult Carcass
186.7
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
349.425
Larval Midgut
233.3
Larval Hindgut
346.2
Larval Malpighian Tubules
79.3
Larval Fat Body
91.7
Larval Salivary Gland
324.3
Larval Trachea
317.9
Larval Carcass
275.8
Adult Head
187.9
Adult Eye
163.675
Adult Brain
333.4
Adult Thoracic-Abdominal Ganglion
310.8
Adult Crop
189
Adult Midgut
373.1
Adult Hindgut
268.2
Adult Malpighian Tubules
217.5
Adult Fat Body
233.2
Adult Salivary Gland
219.6
Adult Heart
211.55
Adult VirginFemale Spermatheca
129.4
Adult InseminatedFemale Spermatheca
138.1
Adult Ovary
660.4
Adult Testis
202.7
Adult Male Accessory Gland
188.5
Adult Carcass
186.7
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
187.9
NA
Eye
163.675
NA
Brain
333.4
349.425
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
310.8
NA
Crop
189
233.3
Midgut
373.1
346.2
Hindgut
268.2
79.3
Malpighian Tubules
217.5
91.7
Fat Body
233.2
324.3
Salivary Gland
219.6
NA
Heart
211.55
317.9
Trachea
NA
NA
VirginFemale Spermatheca
129.4
NA
InseminatedFemale Spermatheca
138.1
NA
Ovary
660.4
NA
Testis
202.7
NA
Male Accessory Gland
188.5
275.8
Carcass
186.7
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
155
central nervous system, larvae L3
66
central nervous system, pupae P8
62
head, virgin 1-day female
31
head, virgin 4-day female
25
head, virgin 20-day female
26
head, mated 1-day female
29
head, mated 4-day female
30
head, mated 20-day female
27
head, mated 1-day male
37
head, mated 4-day male
41
head, mated 20-day male
51
salivary gland, larvae L3 wandering
6
salivary gland, white prepupae
9
digestive system, larvae L3 wandering
28
digestive system, 1-day adult
55
digestive system, 4-day adult
59
digestive system, 20-day adult
51
fat body, larvae L3 wandering
9
fat body, white prepupae
20
fat body, pupae P8
61
carcass, larvae L3 wandering
41
carcass, 1-day adult
28
carcass, 4-day adult
39
carcass, 20-day adult
36
ovary, virgin 4-day female
201
ovary, mated 4-day female
169
testis, mated 4-day male
97
accessory gland, mated 4-day male
40
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(155)
central nervous system, larvae L3
(66)
central nervous system, pupae P8
(62)
head, virgin 1-day female
(31)
head, virgin 4-day female
25
head, virgin 20-day female
26
head, mated 1-day female
(29)
head, mated 4-day female
(30)
head, mated 20-day female
(27)
head, mated 1-day male
(37)
head, mated 4-day male
(41)
head, mated 20-day male
(51)
salivary gland, larvae L3 wandering
6
salivary gland, white prepupae
9
digestive system, larvae L3 wandering
(28)
digestive system, 1-day adult
(55)
digestive system, 4-day adult
(59)
digestive system, 20-day adult
(51)
fat body, larvae L3 wandering
9
fat body, white prepupae
20
fat body, pupae P8
(61)
carcass, larvae L3 wandering
(41)
carcass, 1-day adult
(28)
carcass, 4-day adult
(39)
carcass, 20-day adult
(36)
ovary, virgin 4-day female
(201)
ovary, mated 4-day female
(169)
testis, mated 4-day male
(97)
accessory gland, mated 4-day male
(40)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(155)
central nervous system, larvae L3
66
central nervous system, pupae P8
62
head, virgin 1-day female
31
head, virgin 4-day female
25
head, virgin 20-day female
26
head, mated 1-day female
29
head, mated 4-day female
30
head, mated 20-day female
27
head, mated 1-day male
37
head, mated 4-day male
41
head, mated 20-day male
51
salivary gland, larvae L3 wandering
6
salivary gland, white prepupae
9
digestive system, larvae L3 wandering
28
digestive system, 1-day adult
55
digestive system, 4-day adult
59
digestive system, 20-day adult
51
fat body, larvae L3 wandering
9
fat body, white prepupae
20
fat body, pupae P8
61
carcass, larvae L3 wandering
41
carcass, 1-day adult
28
carcass, 4-day adult
39
carcass, 20-day adult
36
ovary, virgin 4-day female
(201)
ovary, mated 4-day female
(169)
testis, mated 4-day male
97
accessory gland, mated 4-day male
40
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
155
central nervous system, larvae L3
66
central nervous system, pupae P8
62
head, virgin 1-day female
31
head, virgin 4-day female
25
head, virgin 20-day female
26
head, mated 1-day female
29
head, mated 4-day female
30
head, mated 20-day female
27
head, mated 1-day male
37
head, mated 4-day male
41
head, mated 20-day male
51
salivary gland, larvae L3 wandering
6
salivary gland, white prepupae
9
digestive system, larvae L3 wandering
28
digestive system, 1-day adult
55
digestive system, 4-day adult
59
digestive system, 20-day adult
51
fat body, larvae L3 wandering
9
fat body, white prepupae
20
fat body, pupae P8
61
carcass, larvae L3 wandering
41
carcass, 1-day adult
28
carcass, 4-day adult
39
carcass, 20-day adult
36
ovary, virgin 4-day female
201
ovary, mated 4-day female
169
testis, mated 4-day male
97
accessory gland, mated 4-day male
40
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
155
central nervous system, larvae L3
66
central nervous system, pupae P8
62
head, virgin 1-day female
31
head, virgin 4-day female
25
head, virgin 20-day female
26
head, mated 1-day female
29
head, mated 4-day female
30
head, mated 20-day female
27
head, mated 1-day male
37
head, mated 4-day male
41
head, mated 20-day male
51
salivary gland, larvae L3 wandering
6
salivary gland, white prepupae
9
digestive system, larvae L3 wandering
28
digestive system, 1-day adult
55
digestive system, 4-day adult
59
digestive system, 20-day adult
51
fat body, larvae L3 wandering
9
fat body, white prepupae
20
fat body, pupae P8
61
carcass, larvae L3 wandering
41
carcass, 1-day adult
28
carcass, 4-day adult
39
carcass, 20-day adult
36
ovary, virgin 4-day female
201
ovary, mated 4-day female
169
testis, mated 4-day male
97
accessory gland, mated 4-day male
40
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(155)
central nervous system, larvae L3
(66)
central nervous system, pupae P8
(62)
head, virgin 1-day female
31
head, virgin 4-day female
25
head, virgin 20-day female
26
head, mated 1-day female
29
head, mated 4-day female
30
head, mated 20-day female
27
head, mated 1-day male
(37)
head, mated 4-day male
(41)
head, mated 20-day male
(51)
salivary gland, larvae L3 wandering
6
salivary gland, white prepupae
9
digestive system, larvae L3 wandering
28
digestive system, 1-day adult
(55)
digestive system, 4-day adult
(59)
digestive system, 20-day adult
(51)
fat body, larvae L3 wandering
9
fat body, white prepupae
20
fat body, pupae P8
(61)
carcass, larvae L3 wandering
(41)
carcass, 1-day adult
28
carcass, 4-day adult
(39)
carcass, 20-day adult
(36)
ovary, virgin 4-day female
(201)
ovary, mated 4-day female
(169)
testis, mated 4-day male
(97)
accessory gland, mated 4-day male
(40)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(155)
central nervous system, larvae L3
66
central nervous system, pupae P8
62
head, virgin 1-day female
31
head, virgin 4-day female
25
head, virgin 20-day female
26
head, mated 1-day female
29
head, mated 4-day female
30
head, mated 20-day female
27
head, mated 1-day male
37
head, mated 4-day male
41
head, mated 20-day male
51
salivary gland, larvae L3 wandering
6
salivary gland, white prepupae
9
digestive system, larvae L3 wandering
28
digestive system, 1-day adult
55
digestive system, 4-day adult
59
digestive system, 20-day adult
51
fat body, larvae L3 wandering
9
fat body, white prepupae
20
fat body, pupae P8
61
carcass, larvae L3 wandering
41
carcass, 1-day adult
28
carcass, 4-day adult
39
carcass, 20-day adult
36
ovary, virgin 4-day female
(201)
ovary, mated 4-day female
(169)
testis, mated 4-day male
97
accessory gland, mated 4-day male
40
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
155
central nervous system, larvae L3
66
central nervous system, pupae P8
62
head, virgin 1-day female
31
head, virgin 4-day female
25
head, virgin 20-day female
26
head, mated 1-day female
29
head, mated 4-day female
30
head, mated 20-day female
27
head, mated 1-day male
37
head, mated 4-day male
41
head, mated 20-day male
51
salivary gland, larvae L3 wandering
6
salivary gland, white prepupae
9
digestive system, larvae L3 wandering
28
digestive system, 1-day adult
55
digestive system, 4-day adult
59
digestive system, 20-day adult
51
fat body, larvae L3 wandering
9
fat body, white prepupae
20
fat body, pupae P8
61
carcass, larvae L3 wandering
41
carcass, 1-day adult
28
carcass, 4-day adult
39
carcass, 20-day adult
36
ovary, virgin 4-day female
201
ovary, mated 4-day female
169
testis, mated 4-day male
97
accessory gland, mated 4-day male
40
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
154
embryo 02-04hr
54
embryo 04-06hr
59
embryo 06-08hr
79
embryo 08-10hr
79
embryo 10-12hr
94
embryo 12-14hr
80
embryo 14-16hr
114
embryo 16-18hr
113
embryo 18-20hr
105
embryo 20-22hr
102
embryo 22-24hr
87
larva L1
150
larva L2
169
larva L3 12hr old
110
larva L3 puffstage 1-2
28
larva L3 puffstage 3-6
31
larva L3 puffstage 7-9
33
white prepupae new
32
white prepupae 12hr
33
white prepupae 24hr
46
pupae 2d postWPP
84
pupae 3d postWPP
136
pupae 4d postWPP
52
adult male 01day
42
adult male 05day
38
adult male 30day
38
adult female 01day
87
adult female 05day
123
adult female 30day
125
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(154)
embryo 02-04hr
(54)
embryo 04-06hr
(59)
embryo 06-08hr
(79)
embryo 08-10hr
(79)
embryo 10-12hr
(94)
embryo 12-14hr
(80)
embryo 14-16hr
(114)
embryo 16-18hr
(113)
embryo 18-20hr
(105)
embryo 20-22hr
(102)
embryo 22-24hr
(87)
larva L1
(150)
larva L2
(169)
larva L3 12hr old
(110)
larva L3 puffstage 1-2
(28)
larva L3 puffstage 3-6
(31)
larva L3 puffstage 7-9
(33)
white prepupae new
(32)
white prepupae 12hr
(33)
white prepupae 24hr
(46)
pupae 2d postWPP
(84)
pupae 3d postWPP
(136)
pupae 4d postWPP
(52)
adult male 01day
(42)
adult male 05day
(38)
adult male 30day
(38)
adult female 01day
(87)
adult female 05day
(123)
adult female 30day
(125)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
(154)
embryo 02-04hr
54
embryo 04-06hr
59
embryo 06-08hr
79
embryo 08-10hr
79
embryo 10-12hr
94
embryo 12-14hr
80
embryo 14-16hr
(114)
embryo 16-18hr
(113)
embryo 18-20hr
105
embryo 20-22hr
102
embryo 22-24hr
87
larva L1
(150)
larva L2
(169)
larva L3 12hr old
(110)
larva L3 puffstage 1-2
28
larva L3 puffstage 3-6
31
larva L3 puffstage 7-9
33
white prepupae new
32
white prepupae 12hr
33
white prepupae 24hr
46
pupae 2d postWPP
84
pupae 3d postWPP
(136)
pupae 4d postWPP
52
adult male 01day
42
adult male 05day
38
adult male 30day
38
adult female 01day
87
adult female 05day
(123)
adult female 30day
(125)
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
154
embryo 02-04hr
54
embryo 04-06hr
59
embryo 06-08hr
79
embryo 08-10hr
79
embryo 10-12hr
94
embryo 12-14hr
80
embryo 14-16hr
114
embryo 16-18hr
113
embryo 18-20hr
105
embryo 20-22hr
102
embryo 22-24hr
87
larva L1
150
larva L2
169
larva L3 12hr old
110
larva L3 puffstage 1-2
28
larva L3 puffstage 3-6
31
larva L3 puffstage 7-9
33
white prepupae new
32
white prepupae 12hr
33
white prepupae 24hr
46
pupae 2d postWPP
84
pupae 3d postWPP
136
pupae 4d postWPP
52
adult male 01day
42
adult male 05day
38
adult male 30day
38
adult female 01day
87
adult female 05day
123
adult female 30day
125
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
154
embryo 02-04hr
54
embryo 04-06hr
59
embryo 06-08hr
79
embryo 08-10hr
79
embryo 10-12hr
94
embryo 12-14hr
80
embryo 14-16hr
114
embryo 16-18hr
113
embryo 18-20hr
105
embryo 20-22hr
102
embryo 22-24hr
87
larva L1
150
larva L2
169
larva L3 12hr old
110
larva L3 puffstage 1-2
28
larva L3 puffstage 3-6
31
larva L3 puffstage 7-9
33
white prepupae new
32
white prepupae 12hr
33
white prepupae 24hr
46
pupae 2d postWPP
84
pupae 3d postWPP
136
pupae 4d postWPP
52
adult male 01day
42
adult male 05day
38
adult male 30day
38
adult female 01day
87
adult female 05day
123
adult female 30day
125
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(154)
embryo 02-04hr
(54)
embryo 04-06hr
(59)
embryo 06-08hr
(79)
embryo 08-10hr
(79)
embryo 10-12hr
(94)
embryo 12-14hr
(80)
embryo 14-16hr
(114)
embryo 16-18hr
(113)
embryo 18-20hr
(105)
embryo 20-22hr
(102)
embryo 22-24hr
(87)
larva L1
(150)
larva L2
(169)
larva L3 12hr old
(110)
larva L3 puffstage 1-2
28
larva L3 puffstage 3-6
31
larva L3 puffstage 7-9
(33)
white prepupae new
32
white prepupae 12hr
(33)
white prepupae 24hr
(46)
pupae 2d postWPP
(84)
pupae 3d postWPP
(136)
pupae 4d postWPP
(52)
adult male 01day
(42)
adult male 05day
(38)
adult male 30day
(38)
adult female 01day
(87)
adult female 05day
(123)
adult female 30day
(125)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
(154)
embryo 02-04hr
54
embryo 04-06hr
59
embryo 06-08hr
79
embryo 08-10hr
79
embryo 10-12hr
94
embryo 12-14hr
80
embryo 14-16hr
114
embryo 16-18hr
113
embryo 18-20hr
105
embryo 20-22hr
102
embryo 22-24hr
87
larva L1
(150)
larva L2
(169)
larva L3 12hr old
110
larva L3 puffstage 1-2
28
larva L3 puffstage 3-6
31
larva L3 puffstage 7-9
33
white prepupae new
32
white prepupae 12hr
33
white prepupae 24hr
46
pupae 2d postWPP
84
pupae 3d postWPP
136
pupae 4d postWPP
52
adult male 01day
42
adult male 05day
38
adult male 30day
38
adult female 01day
87
adult female 05day
123
adult female 30day
125
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
154
embryo 02-04hr
54
embryo 04-06hr
59
embryo 06-08hr
79
embryo 08-10hr
79
embryo 10-12hr
94
embryo 12-14hr
80
embryo 14-16hr
114
embryo 16-18hr
113
embryo 18-20hr
105
embryo 20-22hr
102
embryo 22-24hr
87
larva L1
150
larva L2
169
larva L3 12hr old
110
larva L3 puffstage 1-2
28
larva L3 puffstage 3-6
31
larva L3 puffstage 7-9
33
white prepupae new
32
white prepupae 12hr
33
white prepupae 24hr
46
pupae 2d postWPP
84
pupae 3d postWPP
136
pupae 4d postWPP
52
adult male 01day
42
adult male 05day
38
adult male 30day
38
adult female 01day
87
adult female 05day
123
adult female 30day
125
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
161
Schneider line 2 Sg4
115
embryonic 1182-4H
135
embryonic GM2
63
embryonic Kc167
48
embryonic S1
204
embryonic S3
157
leg disc CME L1
163
wing disc CME-W2
78
wing disc ML-DmD8
120
wing disc ML-DmD9
199
wing disc ML-DmD16-c3
156
wing disc ML-DmD21
248
wing disc ML-DmD32
134
haltere disc ML-DmD17-c3
141
eye-antennal disc ML-DmD11
154
antennal disc ML-DmD20-c5
144
mixed discs ML-DmD4-c1
105
CNS ML-DmBG1-c1
243
CNS ML-DmBG2-c2
68
tumorous blood cells mbn2
82
ovary fGS/OSS
88
ovary OSC
133
ovary OSS
26
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(161)
Schneider line 2 Sg4
(115)
embryonic 1182-4H
(135)
embryonic GM2
(63)
embryonic Kc167
(48)
embryonic S1
(204)
embryonic S3
(157)
leg disc CME L1
(163)
wing disc CME-W2
(78)
wing disc ML-DmD8
(120)
wing disc ML-DmD9
(199)
wing disc ML-DmD16-c3
(156)
wing disc ML-DmD21
(248)
wing disc ML-DmD32
(134)
haltere disc ML-DmD17-c3
(141)
eye-antennal disc ML-DmD11
(154)
antennal disc ML-DmD20-c5
(144)
mixed discs ML-DmD4-c1
(105)
CNS ML-DmBG1-c1
(243)
CNS ML-DmBG2-c2
(68)
tumorous blood cells mbn2
(82)
ovary fGS/OSS
(88)
ovary OSC
(133)
ovary OSS
26
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
(161)
Schneider line 2 Sg4
(115)
embryonic 1182-4H
(135)
embryonic GM2
63
embryonic Kc167
48
embryonic S1
(204)
embryonic S3
(157)
leg disc CME L1
(163)
wing disc CME-W2
78
wing disc ML-DmD8
(120)
wing disc ML-DmD9
(199)
wing disc ML-DmD16-c3
(156)
wing disc ML-DmD21
(248)
wing disc ML-DmD32
(134)
haltere disc ML-DmD17-c3
(141)
eye-antennal disc ML-DmD11
(154)
antennal disc ML-DmD20-c5
(144)
mixed discs ML-DmD4-c1
105
CNS ML-DmBG1-c1
(243)
CNS ML-DmBG2-c2
68
tumorous blood cells mbn2
82
ovary fGS/OSS
88
ovary OSC
(133)
ovary OSS
26
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
161
Schneider line 2 Sg4
115
embryonic 1182-4H
135
embryonic GM2
63
embryonic Kc167
48
embryonic S1
204
embryonic S3
157
leg disc CME L1
163
wing disc CME-W2
78
wing disc ML-DmD8
120
wing disc ML-DmD9
199
wing disc ML-DmD16-c3
156
wing disc ML-DmD21
248
wing disc ML-DmD32
134
haltere disc ML-DmD17-c3
141
eye-antennal disc ML-DmD11
154
antennal disc ML-DmD20-c5
144
mixed discs ML-DmD4-c1
105
CNS ML-DmBG1-c1
243
CNS ML-DmBG2-c2
68
tumorous blood cells mbn2
82
ovary fGS/OSS
88
ovary OSC
133
ovary OSS
26
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
161
Schneider line 2 Sg4
115
embryonic 1182-4H
135
embryonic GM2
63
embryonic Kc167
48
embryonic S1
204
embryonic S3
157
leg disc CME L1
163
wing disc CME-W2
78
wing disc ML-DmD8
120
wing disc ML-DmD9
199
wing disc ML-DmD16-c3
156
wing disc ML-DmD21
248
wing disc ML-DmD32
134
haltere disc ML-DmD17-c3
141
eye-antennal disc ML-DmD11
154
antennal disc ML-DmD20-c5
144
mixed discs ML-DmD4-c1
105
CNS ML-DmBG1-c1
243
CNS ML-DmBG2-c2
68
tumorous blood cells mbn2
82
ovary fGS/OSS
88
ovary OSC
133
ovary OSS
26
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(161)
Schneider line 2 Sg4
(115)
embryonic 1182-4H
(135)
embryonic GM2
(63)
embryonic Kc167
(48)
embryonic S1
(204)
embryonic S3
(157)
leg disc CME L1
(163)
wing disc CME-W2
(78)
wing disc ML-DmD8
(120)
wing disc ML-DmD9
(199)
wing disc ML-DmD16-c3
(156)
wing disc ML-DmD21
(248)
wing disc ML-DmD32
(134)
haltere disc ML-DmD17-c3
(141)
eye-antennal disc ML-DmD11
(154)
antennal disc ML-DmD20-c5
(144)
mixed discs ML-DmD4-c1
(105)
CNS ML-DmBG1-c1
(243)
CNS ML-DmBG2-c2
(68)
tumorous blood cells mbn2
(82)
ovary fGS/OSS
(88)
ovary OSC
(133)
ovary OSS
26
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
(161)
Schneider line 2 Sg4
115
embryonic 1182-4H
135
embryonic GM2
63
embryonic Kc167
48
embryonic S1
(204)
embryonic S3
(157)
leg disc CME L1
(163)
wing disc CME-W2
78
wing disc ML-DmD8
120
wing disc ML-DmD9
(199)
wing disc ML-DmD16-c3
(156)
wing disc ML-DmD21
(248)
wing disc ML-DmD32
134
haltere disc ML-DmD17-c3
141
eye-antennal disc ML-DmD11
(154)
antennal disc ML-DmD20-c5
(144)
mixed discs ML-DmD4-c1
105
CNS ML-DmBG1-c1
(243)
CNS ML-DmBG2-c2
68
tumorous blood cells mbn2
82
ovary fGS/OSS
88
ovary OSC
133
ovary OSS
26
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
161
Schneider line 2 Sg4
115
embryonic 1182-4H
135
embryonic GM2
63
embryonic Kc167
48
embryonic S1
204
embryonic S3
157
leg disc CME L1
163
wing disc CME-W2
78
wing disc ML-DmD8
120
wing disc ML-DmD9
199
wing disc ML-DmD16-c3
156
wing disc ML-DmD21
248
wing disc ML-DmD32
134
haltere disc ML-DmD17-c3
141
eye-antennal disc ML-DmD11
154
antennal disc ML-DmD20-c5
144
mixed discs ML-DmD4-c1
105
CNS ML-DmBG1-c1
243
CNS ML-DmBG2-c2
68
tumorous blood cells mbn2
82
ovary fGS/OSS
88
ovary OSC
133
ovary OSS
26
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
45
cold shock, 4-day adult
26
heat shock, 4-day adult
76
Cadmium 50 mM 6 hrs, larvae L3
54
Cadmium 50 mM 12 hrs, larvae L3
29
Cadmium 50 mM 48 hrs, 4-day adult
78
Cadmium 100 mM 48 hrs, 4-day adult
106
Copper 0.5 mM 12 hrs, larvae L3
34
Copper 15 mM 48 hrs, 4-day adult
33
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
107
Ethanol 5% 3 hrs, larvae L3
37
Ethanol 10% 3 hrs, larvae L3
57
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
106
Caffeine 25 mg/ml 48 hrs, 4-day adult
50
Paraquat 5 mM 48 hrs, 4-day adult
91
Paraquat 10 mM 48 hrs, 4-day adult
84
Rotenone 2 μg 12 hrs, larvae L3
51
Rotenone 8 μg 12 hrs, larvae L3
90
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(45)
cold shock, 4-day adult
26
heat shock, 4-day adult
(76)
Cadmium 50 mM 6 hrs, larvae L3
(54)
Cadmium 50 mM 12 hrs, larvae L3
(29)
Cadmium 50 mM 48 hrs, 4-day adult
(78)
Cadmium 100 mM 48 hrs, 4-day adult
(106)
Copper 0.5 mM 12 hrs, larvae L3
(34)
Copper 15 mM 48 hrs, 4-day adult
(33)
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
(107)
Ethanol 5% 3 hrs, larvae L3
(37)
Ethanol 10% 3 hrs, larvae L3
(57)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(106)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(50)
Paraquat 5 mM 48 hrs, 4-day adult
(91)
Paraquat 10 mM 48 hrs, 4-day adult
(84)
Rotenone 2 μg 12 hrs, larvae L3
(51)
Rotenone 8 μg 12 hrs, larvae L3
(90)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
45
cold shock, 4-day adult
26
heat shock, 4-day adult
76
Cadmium 50 mM 6 hrs, larvae L3
54
Cadmium 50 mM 12 hrs, larvae L3
29
Cadmium 50 mM 48 hrs, 4-day adult
78
Cadmium 100 mM 48 hrs, 4-day adult
106
Copper 0.5 mM 12 hrs, larvae L3
34
Copper 15 mM 48 hrs, 4-day adult
33
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
107
Ethanol 5% 3 hrs, larvae L3
37
Ethanol 10% 3 hrs, larvae L3
57
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
106
Caffeine 25 mg/ml 48 hrs, 4-day adult
50
Paraquat 5 mM 48 hrs, 4-day adult
91
Paraquat 10 mM 48 hrs, 4-day adult
84
Rotenone 2 μg 12 hrs, larvae L3
51
Rotenone 8 μg 12 hrs, larvae L3
90
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
45
cold shock, 4-day adult
26
heat shock, 4-day adult
76
Cadmium 50 mM 6 hrs, larvae L3
54
Cadmium 50 mM 12 hrs, larvae L3
29
Cadmium 50 mM 48 hrs, 4-day adult
78
Cadmium 100 mM 48 hrs, 4-day adult
106
Copper 0.5 mM 12 hrs, larvae L3
34
Copper 15 mM 48 hrs, 4-day adult
33
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
107
Ethanol 5% 3 hrs, larvae L3
37
Ethanol 10% 3 hrs, larvae L3
57
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
106
Caffeine 25 mg/ml 48 hrs, 4-day adult
50
Paraquat 5 mM 48 hrs, 4-day adult
91
Paraquat 10 mM 48 hrs, 4-day adult
84
Rotenone 2 μg 12 hrs, larvae L3
51
Rotenone 8 μg 12 hrs, larvae L3
90
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
45
cold shock, 4-day adult
26
heat shock, 4-day adult
76
Cadmium 50 mM 6 hrs, larvae L3
54
Cadmium 50 mM 12 hrs, larvae L3
29
Cadmium 50 mM 48 hrs, 4-day adult
78
Cadmium 100 mM 48 hrs, 4-day adult
106
Copper 0.5 mM 12 hrs, larvae L3
34
Copper 15 mM 48 hrs, 4-day adult
33
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
107
Ethanol 5% 3 hrs, larvae L3
37
Ethanol 10% 3 hrs, larvae L3
57
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
106
Caffeine 25 mg/ml 48 hrs, 4-day adult
50
Paraquat 5 mM 48 hrs, 4-day adult
91
Paraquat 10 mM 48 hrs, 4-day adult
84
Rotenone 2 μg 12 hrs, larvae L3
51
Rotenone 8 μg 12 hrs, larvae L3
90
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(45)
cold shock, 4-day adult
26
heat shock, 4-day adult
(76)
Cadmium 50 mM 6 hrs, larvae L3
(54)
Cadmium 50 mM 12 hrs, larvae L3
29
Cadmium 50 mM 48 hrs, 4-day adult
(78)
Cadmium 100 mM 48 hrs, 4-day adult
(106)
Copper 0.5 mM 12 hrs, larvae L3
(34)
Copper 15 mM 48 hrs, 4-day adult
(33)
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
(107)
Ethanol 5% 3 hrs, larvae L3
(37)
Ethanol 10% 3 hrs, larvae L3
(57)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(106)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(50)
Paraquat 5 mM 48 hrs, 4-day adult
(91)
Paraquat 10 mM 48 hrs, 4-day adult
(84)
Rotenone 2 μg 12 hrs, larvae L3
(51)
Rotenone 8 μg 12 hrs, larvae L3
(90)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
45
cold shock, 4-day adult
26
heat shock, 4-day adult
76
Cadmium 50 mM 6 hrs, larvae L3
54
Cadmium 50 mM 12 hrs, larvae L3
29
Cadmium 50 mM 48 hrs, 4-day adult
78
Cadmium 100 mM 48 hrs, 4-day adult
106
Copper 0.5 mM 12 hrs, larvae L3
34
Copper 15 mM 48 hrs, 4-day adult
33
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
107
Ethanol 5% 3 hrs, larvae L3
37
Ethanol 10% 3 hrs, larvae L3
57
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
106
Caffeine 25 mg/ml 48 hrs, 4-day adult
50
Paraquat 5 mM 48 hrs, 4-day adult
91
Paraquat 10 mM 48 hrs, 4-day adult
84
Rotenone 2 μg 12 hrs, larvae L3
51
Rotenone 8 μg 12 hrs, larvae L3
90
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
45
cold shock, 4-day adult
26
heat shock, 4-day adult
76
Cadmium 50 mM 6 hrs, larvae L3
54
Cadmium 50 mM 12 hrs, larvae L3
29
Cadmium 50 mM 48 hrs, 4-day adult
78
Cadmium 100 mM 48 hrs, 4-day adult
106
Copper 0.5 mM 12 hrs, larvae L3
34
Copper 15 mM 48 hrs, 4-day adult
33
Zinc 5 mM 12 hrs, larvae L3
22
Zinc 4.5 mM 48 hrs, 4-day adult
19
Ethanol 2.5% 3 hrs, larvae L3
107
Ethanol 5% 3 hrs, larvae L3
37
Ethanol 10% 3 hrs, larvae L3
57
Caffeine 1.5 mg/ml 4 hrs, larvae L3
23
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
106
Caffeine 25 mg/ml 48 hrs, 4-day adult
50
Paraquat 5 mM 48 hrs, 4-day adult
91
Paraquat 10 mM 48 hrs, 4-day adult
84
Rotenone 2 μg 12 hrs, larvae L3
51
Rotenone 8 μg 12 hrs, larvae L3
90
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 4 ) For All Classical Alleles Show Alleles Carried on Transgenic Constructs
( 7 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Not disrupted in Disrupted in Transgenic Constructs & Insertions
Transgenic Constructs Insertions insertion of enhancer trap
Gene Ontology: Function, Process
& Cellular Component ( 8 unique terms ) Terms Based on
Experimental Evidence ( 4 terms ) Molecular Function inferred from genetic interaction with
His1 Biological Process inferred from mutant phenotype
inferred from mutant phenotype
Cellular Component inferred from direct assay
Terms Based on Predictions or
Assertions ( 4 terms ) Molecular Function inferred from sequence or structural similarity
Biological Process inferred from sequence or structural similarity
Cellular Component inferred from sequence or structural similarity
Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (39)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG6X3HN2 )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans
(EOG6BRWW6 )
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects
(EOG63R2JB )
Apis mellifera
Western honey bee
Amel\GB41068
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009423
Acromyrmex echinatior
Panamanian leafcutter ant
Aech\AECH17236
Atta cephalotes
Leafcutter ant
Acep\ACEP27816
Camponotus floridanus
Florida carpenter ant
Cflo\CFLO13420
Harpegnathos saltator
Jerdons jumping ant
Hsal\HSAL13115
Linepithema humile
Argentine ant
Lhum\LH21398
Pogonomyrmex barbatus
Red harvester ant
Pbar\PB21202
Solenopsis invicta
Red fire ant
Sinv\SINV25947
Acyrthosiphon pisum
Pea aphid
Pediculus humanus
Human body louse
Tribolium castaneum
Red flour beetle
Orthologs in non-Insect Arthropods
(EOG6WPZK6 )
Ixodes scapularis
Deer tick
Orthologs in non-Arthropod Metazoa
(EOG6HTNPB )
Caenorhabditis elegans
Nematode
Strongylocentrotus purpuratus
Purple sea urchin
Xenopus tropicalis
Western clawed frog
Gallus gallus
Domestic chicken
Rattus norvegicus
Norway rat
Human Orthologs (1)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 5 )Bloomington VDRC Genomic Clones ( 1 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 63 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for identity of: mRpL7-L12 CG5012
Source for database merge of Source for merge of: Mrp17 CG5012
Source for merge of: mRpL7-L12 BcDNA:RE53508
Additional comments Source for merge of mRpL7-L12 BcDNA:RE53508 was TrEMBL update (date:020807).
Other Comments External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
- A database of annotated Dmel nuclear genes encoding mitochondrial proteins
- Patterns of gene expression in Drosophila embryogenesis
Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
Synonyms & Secondary IDs
( 14 )Reported As Symbol Synonym l(3)10534
(
Desbordes et al., 2005 ,
Frei and Edgar, 2003 ,
Frei and Edgar, 2002 ,
Tsuda et al., 1999 ,
Meister and Braun, 1995.10 ,
BDGP Project Members, 1994-1999 , )
mRpL12
(
FlyBase Curators, 2008 ,
Cermelli et al., 2006 ,
Chihara et al., 2007 ,
Chihara et al., 2007 ,
Marygold et al., 2007 ,
Georgiev et al., 2010 ,
Casad et al., 2011 ,
Japanese National Institute of Genetics, 2012.5.21 )
Name Synonym Mitochondrial ribosomal protein L5/L17
mitochondrial ribosomal protein L7/L12
mitochondrial ribosomal protein L12
Secondary FlyBase
IDs FBgn0011362 FBgn0011514 FBgn0035940 FBgn0061393 References ( 42 )Generate a list of List References by type
Recent research papers ( 1 )
Casad et al., 2011, Genetics 189(3): 861--870Cardiomyopathy Is Associated with Ribosomal Protein Gene Haplo-Insufficiency in Drosophila melanogaster. [FBrf0216591]
Recent reviews (0)
All reviews listed in FlyBase were published before 2011