FlyBase Gene Report: Dmel\nmo

General Information

Symbol

Dmel\nmo

Species

D. melanogaster

Name

nemo

Annotation Symbol

CG7892

Feature Type

protein_coding_gene

FlyBase ID

FBgn0011817

Gene Model Status

Current

Stock Availability

28 publicly available

Enzyme Name (EC)

Mitogen-activated protein kinase (2.7.11.24)

Gene Summary

nemo (nmo) encodes an atypical proline-directed serine/threonine kinase with roles in numerous developmental processes, including ommatidial rotation/planar cell polarity, retinal specification and neuronal function, and circadian clock speed. It regulates the activity of several signal transduction pathways, including BMP, Wnt, and Notch, and is implicated in fly models of neurodegenerative diseases. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Pathway
Gene Group
Interactive Fly

Also Known As

Nlk, adk, Nemo-like kinase, adirondack

Key Links

Genomic Location

Cytogenetic map

66A22-66B3

Sequence location

3L:7,979,046..8,054,147 [+]

Recombination map

3-21

RefSeq locus

NT_037436 REGION:7979046..8054147

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (17 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables protein kinase activity

inferred from direct assay

(Zeng et al., 2007)

enables protein serine/threonine kinase activity

inferred from direct assay

(Collu et al., 2018, Morillo et al., 2012, Mirkovic et al., 2011)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables ATP binding

inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR003527, InterPro:IPR017441

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables MAP kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN001934972

(assigned by GO_Central )

(Gaudet et al., 2011)

enables protein serine/threonine kinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (11 terms)

Terms Based on Experimental Evidence (10 terms)

CV Term

Evidence

References

involved_in compound eye development

inferred from mutant phenotype

(Choi and Benzer, 1994)

involved_in gravitaxis

inferred from mutant phenotype

(Toma et al., 2002)

involved_in imaginal disc-derived wing morphogenesis

inferred from mutant phenotype

(Verheyen et al., 2001)

involved_in imaginal disc-derived wing vein specification

inferred from mutant phenotype

(Verheyen et al., 2001)

involved_in negative regulation of canonical Wnt signaling pathway

inferred from genetic interaction with FLYBASE:arm; FB:FBgn0000117

(Zeng and Verheyen, 2004)

inferred from genetic interaction with FLYBASE:sgg; FB:FBgn0003371

(Zeng and Verheyen, 2004)

inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797

(Zeng and Verheyen, 2004)

inferred from genetic interaction with FLYBASE:Axn; FB:FBgn0026597

(Zeng and Verheyen, 2004)

involved_in ommatidial rotation

inferred from mutant phenotype

(Muñoz-Soriano et al., 2013, Fiehler and Wolff, 2008, Chou and Chien, 2002)

involved_in positive regulation of synaptic assembly at neuromuscular junction

inferred from mutant phenotype

(Merino et al., 2009)

involved_in protein autophosphorylation

inferred from direct assay

(Morillo et al., 2012)

involved_in regulation of establishment of planar polarity

inferred from genetic interaction with FLYBASE:pk; FB:FBgn0003090, FLYBASE:Vang; FB:FBgn0015838

(Mirkovic et al., 2011)

inferred from genetic interaction with FLYBASE:gish; FB:FBgn0250823

(Weber et al., 2012)

inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085

(Zheng et al., 1995)

inferred from genetic interaction with FLYBASE:pk; FB:FBgn0003090

(Collu et al., 2018)

involved_in wing disc dorsal/ventral pattern formation

inferred from mutant phenotype

(Zeng and Verheyen, 2004)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in intracellular signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(assigned by GO_Central )

(Gaudet et al., 2011)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000622075

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in nucleus

inferred from sequence or structural similarity with MGI:MGI:1201387

(FlyBase Curators, 2008-)

Gene Group (FlyBase)

ATYPICAL MITOGEN ACTIVATED PROTEIN KINASES

Pathway (FlyBase)

Negative Regulators of Wnt-TCF Signaling Pathway

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC)

Experimental Evidence

Predictions / Assertions

ATP + a protein = ADP + a phosphoprotein (2.7.11.24)

Summaries

Gene Snapshot

Gene Group (FlyBase)

ATYPICAL MITOGEN ACTIVATED PROTEIN KINASES -: Atypical Mitogen-activated protein kinases are proline-directed serine/threonine kinases that share significant sequence homology with the kinase domain of conventional MAPKs. They are not part of the conventional MAPK cascade and differ in key residues of the activation loop. (Adapted from PMID:21372320).

Pathway (FlyBase)

Negative Regulators of Wnt-TCF Signaling Pathway -: Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).

Summary (Interactive Fly)

protein serine/threonine kinase involved in establishing ommatidial rotation/planar cell polarity, retinal specification and neuronal function, and circadian clock speed - regulates the activity of several signal transduction pathways, including BMP, Wnt, and Notch - implicated in fly models of neurodegenerative diseases

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\nmo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry A0A4D6K823)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Stop-codon suppression (UGA) postulated; FBrf0234051.

Gene model reviewed during 6.25

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2016)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

nmo-RA

FBtr0076754

NM_168251

5131

414

nmo-RB

FBtr0076755

NM_168252

3131

414

nmo-RC

FBtr0076757

NM_079243

2624

414

nmo-RE

FBtr0076756

NM_168248

2421

430

nmo-RF

FBtr0076758

NM_168249

2757

430

nmo-RG

FBtr0076759

NM_168250

2250

430

nmo-RH

FBtr0333223

NM_001274626

6235

430

nmo-RI

FBtr0474156

NM_001370048

2250

439

Additional Transcript Data and Comments

Reported size (kB)

7.6, 7.2, 5.8, 5.4, 4.6, 4.1, 3.6, 3.2 (northern blot)

(Choi and Benzer, 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

nmo-PA

FBpp0076471

46.4

414

7.93

FBpp0076472

46.4

414

7.93

FBpp0076474

46.4

414

7.93

FBpp0076473

48.2

430

7.61

FBpp0076475

48.2

430

7.61

FBpp0076476

48.2

430

7.61

FBpp0305425

48.2

430

7.61

FBpp0423155

49.1

439

7.61

QCD26219

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

414 aa isoforms: nmo-PA, nmo-PB, nmo-PC

430 aa isoforms: nmo-PE, nmo-PF, nmo-PG, nmo-PH

Additional Polypeptide Data and Comments

Reported size (kDa)

477, 434 (aa)

(Choi and Benzer, 1994)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nmo using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

nmo_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:

low

high

Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.

Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:

low

high

as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Choi and Benzer, 1994)

third instar larval stage

eye disc morphogenetic furrow

(Choi and Benzer, 1994)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 5

organism | ubiquitous

Comment: maternally deposited

(Verheyen et al., 2001)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 6 -- 10

somatic cell

Comment: zygotic expression in most cells

(Verheyen et al., 2001)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 12

organism | segmentally repeated

(Verheyen et al., 2001)

embryonic segment | anterior

Comment: expression is in denticle-secreting cells

(Verheyen et al., 2001)

embryonic stage 9 -- 17

organism

Comment: extended 3' UTR isoform

(Hilgers et al., 2011)

embryonic stage 10 -- 13

tracheal pit

(Verheyen et al., 2001)

embryonic stage 11 -- 12

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 11 -- 17

presumptive embryonic/larval central nervous system

(Verheyen et al., 2001)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic dorsal epidermis

(Fisher et al., 2012)

embryonic head epidermis

(Fisher et al., 2012)

embryonic head sensory system

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

embryonic/larval nervous system

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

embryonic optic lobe primordium

(Fisher et al., 2012)

larval stage

eye disc posterior to the morphogenetic furrow

Comment: narrow stripe

(Choi and Benzer, 1994)

eye disc | ubiquitous

Comment: low level, isoform-specific

(Choi and Benzer, 1994)

pupal stage P6

wing cell

Comment: 25-30 hr APF; expression is enriched immediately adjacent to wing veins

(Verheyen et al., 2001)

Additional Descriptive Data

Isoforms of nmo with extended 3' UTRs appear later in embryogenesis. Sequential, phased, 3' UTR lengthening is seen (3' UTR lengthening ocurring in multiple steps during later stages of embryogenesis).

(Hilgers et al., 2011)

One nmo isoform is expressed in a stripe posterior the morphogenetic furrow. The other is expressed at low levels throughout the disc.

(Ma and Moses, 1995)

nmo transcripts are expressed in a complex pattern throughout development. Six transcripts are expressed in early embryos, (3.2, 3.6, 4.1, 4.6, 5.4, and 5.8 kb). A 7.2kb transcript appears in late embryos and a 7.6kb transcript is detected in adult heads. The seven transcripts are all developmentally regulated with varying patterns. In general, transcription is highest in embryos, third instar larvae, and pupae.

(Choi and Benzer, 1994)

nmo transcripts are detected close to the morphogenetic furrow in third instar eye discs.

(Choi and Benzer, 1994)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: Mi{Trojan-GAL4.2}nmo^{MI03101-TG4.2}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain | restricted

(Lee et al., 2018)

adult mushroom body

(Lee et al., 2018)

Reporter: P{lacW}nmo^P1

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

larval ventral nerve cord

(Merino et al., 2009)

embryonic stage 5

organism | ubiquitous

(Braid et al., 2010)

embryonic stage 6

organism | restricted

(Braid et al., 2010)

embryonic stage 6 -- 11

organism | restricted

(Braid et al., 2010)

embryonic stage 7 -- 14

organism | segment polarity expression pattern

(Braid et al., 2010)

embryonic stage 15

organism | restricted

Comment: segment boundaries

(Braid et al., 2010)

second instar larval stage

eye disc

(Braid and Verheyen, 2008)

third instar larval stage

photoreceptor neuron | presumptive

(Choi and Benzer, 1994)

eye disc morphogenetic furrow

(Braid and Verheyen, 2008, Choi and Benzer, 1994)

eye disc posterior to the morphogenetic furrow

(Braid and Verheyen, 2008)

presumptive ocellus

(Braid and Verheyen, 2008)

presumptive third segment of antenna

(Braid and Verheyen, 2008)

adult stage

s-LNv neuron | subset

(Yu et al., 2011)

l-LNv neuron | subset

(Yu et al., 2011)

LNd neuron | subset

(Yu et al., 2011)

DN1 neuron

(Yu et al., 2011)

third instar larval stage

eye disc posterior to the morphogenetic furrow

(Choi and Benzer, 1994)

Reporter: P{ST.lexA::HG}nmo^FW-1

Stage

Tissue/Position (including subcellular localization)

Reference

wandering third instar larval stage

embryonic/larval central nervous system

(Bloomington Drosophila Stock Center, 2019)

larval ventral nerve cord

(Bloomington Drosophila Stock Center, 2019)

larval insulin secreting cell of pars intercerebralis

(Bloomington Drosophila Stock Center, 2019)

embryonic/larval midgut

(Bloomington Drosophila Stock Center, 2019)

embryonic/larval fat body

(Bloomington Drosophila Stock Center, 2019)

embryonic/larval salivary gland

(Bloomington Drosophila Stock Center, 2019)

Reporter: PBac{810.P.FSVS-2}nmo^CPTI004543

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\nmo in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\nmo

View exonic expression by tissue for Dmel\nmo

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0011817

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38890/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011817

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011817

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011817

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7892

Flygut - An atlas of the Drosophila adult midgut

FBgn0011817

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\nmo

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 41 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 18 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of nmo

Transgenic constructs containing regulatory region of nmo

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(3L)Exel6279

(Ryder, 2004.4.26)

Df(3L)pbl-NR

(Verheyen et al., 2001, Choi and Benzer, 1994)

Df(3L)pbl-X1

(Choi and Benzer, 1994)

Gene not disrupted in

Df(3L)8

(Choi and Benzer, 1994)

Df(3L)25

(Choi and Benzer, 1994)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

nmo^CB04635

lethal - all die before end of P-stage

nmo^DB

lethal - all die during embryonic stage, with Scer\GAL4^69B

nmo^c5-1.UAS

lethal - all die during embryonic stage | germline clone | maternal effect

nmo^adk1

partially lethal - majority die | recessive

viable

nmo^PL00028

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

nmo^GD1495

viable, with Scer\GAL4^Mef2.PR

nmo^GD1495

viable, with Scer\GAL4^pnr-MD237

nmo^GD1495

viable, with Scer\GAL4^tin.CΔ4

nmo^GD1495

Sterility

Allele

female semi-sterile, with Scer\GAL4^nos.PG, Scer\GAL4^VP16.nos.UTR, Scer\GAL4^VP16.otu

nmo^GL00165

female semi-sterile, with Scer\GAL4^{VP16.mat.αTub67C}

fertile

nmo^PL00028

Other Phenotypes

Allele

abnormal behavior | dominant

nmo^P1

abnormal cell death, with Scer\GAL4^69B

nmo^c5-1.UAS

abnormal cell polarity

nmo^P1

abnormal circadian rhythm | adult stage, with Scer\GAL4^P2.4.Pdf

abnormal circadian rhythm | adult stage, with Scer\GAL4^tim.PU

abnormal circadian rhythm | adult stage (with Df(3L)Exel6279)

nmo^P1

abnormal gravitaxis

nmo^P1

abnormal locomotor rhythm, with Scer\GAL4^tim.UAS

abnormal neuroanatomy | third instar larval stage

nmo^unspecified

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^G14

nmo^K69M.UAS.GFP

abnormal neuroanatomy | third instar larval stage (with Df(3L)Exel6279)

nmo^P1

abnormal neuroanatomy | third instar larval stage (with Df(3L)pbl-X1)

abnormal neuroanatomy | third instar larval stage (with nmo^DB24)

nmo^P1

abnormal neuroanatomy | third instar larval stage (with nmo^P1)

nmo^DB24

abnormal planar polarity

abnormal planar polarity, with Scer\GAL4^69B

nmo^c5-1.UAS

abnormal planar polarity, with Scer\GAL4^bs-1348

nmo^c5-1.UAS

abnormal planar polarity, with Scer\GAL4^hs.2sev

nmo^UAS.cUa

abnormal planar polarity (with nmo^j147-1)

nmo^P1

abnormal planar polarity (with nmo^P1)

nmo^j147-1

abnormal planar polarity | recessive

abnormal planar polarity | somatic clone | third instar larval stage

nmo^DB

decreased cell size (with nmo^adk2)

nmo^DB24

decreased cell size (with nmo^DB24)

nmo^adk2

some die during embryonic stage, with Scer\GAL4^69B

nmo^c5-1.UAS

some die during embryonic stage | germline clone | maternal effect | maternal effect

nmo^adk1

some die during pharate adult stage

nmo^DB

visible

visible, with Scer\GAL4^32B

nmo^c5-1.UAS

visible, with Scer\GAL4^69B

visible, with Scer\GAL4^bi.PU

nmo^UAS.cUa

visible (with nmo^adk2)

visible (with nmo^DB24)

nmo^adk2

visible (with nmo^P1)

nmo^adk2

visible | recessive

Phenotype manifest in

Allele

abdominal tergite & macrochaeta, with Scer\GAL4^69B

nmo^c5-1.UAS

abdominal tergite & microchaeta, with Scer\GAL4^69B

nmo^c5-1.UAS

cone cell

nmo^P1

crossvein | ectopic

denticle, with Scer\GAL4^69B

nmo^c5-1.UAS

denticle | germline clone | maternal effect

nmo^adk1

denticle belt, with Scer\GAL4^69B

nmo^c5-1.UAS

denticle belt | germline clone | maternal effect

nmo^adk1

embryo | dorsal closure stage, with Scer\GAL4^69B

nmo^c5-1.UAS

embryonic/first instar larval cuticle, with Scer\GAL4^69B

nmo^c5-1.UAS

embryonic/first instar larval cuticle | germline clone | maternal effect

nmo^adk1

embryonic head, with Scer\GAL4^69B

nmo^c5-1.UAS

embryonic head | germline clone | maternal effect

nmo^adk1

embryonic segment | germline clone | maternal effect

nmo^adk1

eye

eye, with Scer\GAL4^GMR.PU

nmo^UAS.cUa

eye, with Scer\GAL4^hs.2sev

nmo^UAS.cUa

eye (with nmo^adk2)

nmo^P1

eye (with nmo^P1)

nmo^adk2

eye disc

nmo^P1

head bristle

interommatidial bristle

nmo^P1

mesothoracic tergum & macrochaeta

NMJ bouton | third instar larval stage

nmo^unspecified

NMJ bouton | third instar larval stage, with Scer\GAL4^G14

nmo^K69M.UAS.GFP

NMJ bouton | third instar larval stage (with Df(3L)Exel6279)

nmo^P1

NMJ bouton | third instar larval stage (with Df(3L)pbl-X1)

NMJ bouton | third instar larval stage (with nmo^DB24)

nmo^P1

NMJ bouton | third instar larval stage (with nmo^P1)

nmo^DB24

ommatidial precursor cluster

nmo^P1

ommatidial precursor cluster | somatic clone

nmo^DB

ommatidium

ommatidium, with Scer\GAL4^GMR.PU

nmo^UAS.cUa

ommatidium, with Scer\GAL4^hs.2sev

nmo^UAS.cUa

ommatidium (with nmo^adk2)

nmo^P1

ommatidium (with nmo^j147-1)

nmo^P1

ommatidium (with nmo^P1)

ommatidium | somatic clone

nmo^DB

posterior crossvein, with Scer\GAL4^32B

nmo^c5-1.UAS

posterior crossvein, with Scer\GAL4^69B

posterior crossvein, with Scer\GAL4^bi.PU

nmo^UAS.cUa

scutellar bristle, with Scer\GAL4^ap-md544

nmo^c5-1.UAS

scutum & macrochaeta, with Scer\GAL4^ap-md544

nmo^c5-1.UAS

secondary pigment cell

nmo^P1

secondary pigment cell | ectopic

submarginal cell, with Scer\GAL4^bi.PU

nmo^UAS.cUa

tertiary pigment cell | ectopic

type I bouton | third instar larval stage (with Df(3L)Exel6279)

nmo^P1

wing

wing, with Scer\GAL4^69B

nmo^c5-1.UAS

wing, with Scer\GAL4^ap-md544

nmo^c5-1.UAS

wing, with Scer\GAL4^bi.PU

nmo^UAS.cUa

wing | anterior, with Scer\GAL4^69B

nmo^c5-1.UAS

wing blade

nmo^adk2

wing blade, with Scer\GAL4^69B

nmo^UAS.cUa

wing blade (with nmo^adk2)

nmo^DB24

wing blade (with nmo^DB24)

nmo^adk2

wing cell, with Scer\GAL4^bi.PU

nmo^UAS.cUa

wing margin, with Scer\GAL4^sd-SG29.1

nmo^c5-1.UAS

wing vein, with Scer\GAL4^bi.PU

nmo^UAS.cUa

wing vein | ectopic

wing vein | ectopic, with Scer\GAL4^69B

nmo^c5-1.UAS

wing vein | ectopic (with nmo^adk2)

nmo^DB24

wing vein | ectopic (with nmo^DB24)

nmo^adk2

wing vein L2, with Scer\GAL4^69B

nmo^c4-2.UAS

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\NLK

14 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Nlk

14 of 15

Yes

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (16)

Rnor\Nlk

12 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (15)

Xtro\nlk.2

10 of 12

Yes

Xtro\nlk

8 of 12

Yes

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (19)

Drer\nlk2

13 of 15

Yes

Drer\nlk1

6 of 15

Yes

2 of 15

2 of 15

2 of 15

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:ch211-220i18.4

1 of 15

Drer\srpk1a

1 of 15

Drer\srpk3

1 of 15

Drer\zgc:171775

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (12)

Cele\lit-1

14 of 15

Yes

2 of 15

2 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (20)

Atha\MPK1

3 of 9

Yes

Atha\MPK2

3 of 9

Yes

Atha\MPK7

3 of 9

Yes

Atha\MPK14

3 of 9

Yes

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

2 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\KDX1

1 of 15

Yes

Scer\SLT2

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (10)

Gene Symbol

Score

Source

Alignment

bsk

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

nmo^adk1

ameliorates Kennedy's disease

modeled by Hsap\AR^61Q.UAS

(Todd et al., 2015)

nmo^adk2

ameliorates olivopontocerebellar atrophy

modeled by Hsap\ATXN1^82Q.UAS

(Ju et al., 2013)

ameliorates Kennedy's disease

modeled by Hsap\AR^61Q.UAS

(Todd et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

NLK; nemo like kinase

14 of 15

609476

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

nmo

enzymatic study, autoradiography

(Morillo et al., 2012, Zeng et al., 2007)

nmo - Hsp23

experimental knowledge based

(Guruharsha et al., 2011)

nmo - Hsp26

experimental knowledge based

(Guruharsha et al., 2011)

nmo - Mad

enzymatic study, autoradiography, anti tag coimmunoprecipitation, anti tag western blot

(Merino et al., 2009, Zeng et al., 2007)

nmo - Vang

pull down, autoradiography

(Mirkovic et al., 2011)

nmo - eve

anti tag coimmunoprecipitation, anti tag western blot, enzymatic study, western blot, two hybrid

(Braid et al., 2010)

nmo - eya

enzymatic study, autoradiography, anti tag coimmunoprecipitation, anti tag western blot

(Morillo et al., 2012)

nmo - per

protein kinase assay, western blot

(Chiu et al., 2011)

nmo - pk

enzymatic study, autoradiography, pull down

(Collu et al., 2018, Mirkovic et al., 2011)

nmo - sgl

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

nmo

enhanceable

arm

(Mirkovic et al., 2011)

nmo

enhanceable

Axn

(Zeng and Verheyen, 2004)

nmo

suppressible

bsk

(Fiehler and Wolff, 2008, Mirkovic et al., 2002)

nmo

enhanceable

CG32373

(Muñoz-Soriano et al., 2013)

nmo

enhanceable

Clk

(Mahesh et al., 2014)

nmo

enhanceable

Dad

(Zeng et al., 2007)

nmo

suppressible

(Verheyen et al., 2001)

nmo

enhanceable

dpp

(Verheyen et al., 2001)

nmo

suppressible

E(spl)mβ-HLH

(Verheyen et al., 2001)

nmo

enhanceable

Egfr

(Mirkovic et al., 2011)

nmo

suppressible

(Verheyen et al., 2001)

nmo

suppressible

Jra

(Mirkovic et al., 2002)

nmo

enhanceable

miple1

(Muñoz-Soriano et al., 2013)

nmo

suppressible

msn

(Mirkovic et al., 2002)

nmo

enhanceable

mthl8

(Muñoz-Soriano et al., 2013)

nmo

suppressible

(Mirkovic et al., 2011)

nmo

enhanceable

net

(Verheyen et al., 2001)

nmo

suppressible

pan

(Verheyen et al., 2001)

nmo

enhanceable

(Mirkovic et al., 2011)

nmo

suppressible

(Mirkovic et al., 2011)

nmo

enhanceable

Ptp99A

(Muñoz-Soriano et al., 2013)

nmo

enhanceable

(Verheyen et al., 2001)

nmo

suppressible

sca

(Fiehler and Wolff, 2008)

nmo

suppressible

sgg

(Zeng and Verheyen, 2004)

nmo

enhanceable

shg

(Mirkovic et al., 2011)

nmo

enhanceable

spi

(Mirkovic et al., 2011)

nmo

suppressible

Tak1

(Mirkovic et al., 2002)

nmo

enhanceable

Tak1

(Mirkovic et al., 2002)

nmo

suppressible

tkv

(Merino et al., 2009)

nmo

enhanceable

unc-13-4A

(Muñoz-Soriano et al., 2013)

nmo

enhanceable

Vang

(Mirkovic et al., 2011, Mirkovic et al., 2011)

nmo

suppressible

Vang

(Mirkovic et al., 2011)

nmo

suppressible

zip

(Fiehler and Wolff, 2008)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

aos

suppressible

nmo

(Gaengel and Mlodzik, 2003)

arm

suppressible

nmo

(Zeng and Verheyen, 2004)

Axn

suppressible

nmo

(Zeng and Verheyen, 2004)

dgo

enhanceable

nmo

(Wu et al., 2008)

enhanceable

nmo

(Verheyen et al., 2001)

suppressible

nmo

(Montrasio et al., 2007)

fz2

suppressible

nmo

(Zeng and Verheyen, 2004)

gish

suppressible

nmo

(Weber et al., 2012)

enhanceable

nmo

(Verheyen et al., 2001)

hid

suppressible

nmo

(Mirkovic et al., 2002)

Mad

suppressible

nmo

(Zeng et al., 2007)

miple1

enhanceable

nmo

(Muñoz-Soriano et al., 2013)

suppressible

nmo

(Verheyen et al., 1996)

enhanceable

nmo

(Verheyen et al., 1996)

net

enhanceable

nmo

(Verheyen et al., 2001)

pan

suppressible

nmo

(Verheyen et al., 2001)

Pkn

enhanceable

nmo

(Sass and Ostrow, 2014)

enhanceable

nmo

(Verheyen et al., 2001)

Rac1

suppressible

nmo

(Fanto et al., 2000)

rpr

suppressible

nmo

(Mirkovic et al., 2002)

sca

enhanceable

nmo

(Chou and Chien, 2002)

sca

suppressible

nmo

(Chou and Chien, 2002)

Tak1

suppressible

nmo

(Mihaly et al., 2001)

tkv

enhanceable

nmo

(Zeng et al., 2007)

tkv

suppressible

nmo

(Zeng et al., 2007)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

64316

DroID - A comprehensive database of gene and protein interactions.

FBgn0011817

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Negative Regulators of Wnt-TCF Signaling Pathway -: Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0011817

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Ca2+ pathway

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-21

Cytogenetic map

66A22-66B3

Sequence location

3L:7,979,046..8,054,147 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

66A22-66B3

Limits computationally determined from genome sequence between P{PZ}l(3)07217⁰⁸²²³&P{EP}Rac2^EP3118 and P{lacW}Nmt^j1C7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

66B1-66B2

(Choi, 1994.7.7)

66B1-66B2

(determined by in situ hybridisation)

(Choi and Benzer, 1994)

Experimentally Determined Recombination Data

Location

3-21

(FlyBase, 2016)

3-18.6

(Comeron et al., 2012)

3-66

(Verheyen et al., 2001)

(Verheyen et al., 1996, Choi, 1994.7.7)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (28)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

38664

w¹¹¹⁸; PBac{nmo-GFP.FLAG}VK00037

25793

y¹ v¹; P{TRiP.JF01799}attP2

41586

y¹ v¹; P{TRiP.GL00703}attP2

42570

y¹ v¹; P{TRiP.HMJ02229}attP40

60016

y¹ v¹; P{TRiP.HMS05004}attP40

36033

y¹ w^*; Mi{MIC}nmo^MI02715

Kyoto

123552

w¹¹¹⁸; P{RS3}nmo^CB-5300-3

124026

w¹¹¹⁸; P{RS3}nmo^CB-6289-3

125522

w¹¹¹⁸; P{RS5}nmo^5-HA-2008

VDRC

v101545

P{KK109009}VIE-260B

v104885

P{KK107867}VIE-260B

v3002

w¹¹¹⁸; P{GD1495}v3002

More stocks available...

Genomic Clones (41)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (144)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD36031

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0011817

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0011817

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38890

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: nmo anon- EST:Gibbs3

(Verheyen and Artavanis-Tsakonas, 1998, FlyBase, 1996-)

Source for merge of: nmo anon-WO0118547.332 anon-WO0140519.256

(FlyBase, 1996-)

Additional comments

Source for merge of nmo anon- EST:Gibbs3 was sequence comparison ( date:030707 ).

(Verheyen and Artavanis-Tsakonas, 1998, FlyBase, 1996-)

Source for merge of nmo anon-WO0118547.332 anon-WO0140519.256 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Other Comments

nmo is required in the larval eye disc through most of the first 45[o] of ommatidial rotation to regulate the speed at which the ommatidial precursors move. nmo is required in photoreceptors R1, R6 and R7 for normal orientation.

(Fiehler and Wolff, 2008)

When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, spindle abnormalities, centrosome abnormalities, lagging chromatids and a whole range of mitotic abnormalities are seen.

(Bettencourt-Dias et al., 2004)

Overexpressed nmo reduces the levels of arm protein in regions where it is stabilised by wg signaling.

(Zeng and Verheyen, 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Area matching Drosophila Nemo gene, Acc. No. U12010.

(Davies, 2001.3.15)

Area matching Drosophila EST AA439393 (inverted).

(Davies, 2001.3.15)

nmo is required during wing development for wing shape and vein patterning.

(Verheyen et al., 2001)

Genetic interactions between nmo and other mutations implicate nmo as an antagonist of wg.

(Verheyen et al., 2001)

Complementation group isolated in a screen for dominant enhancers and suppressors of N^act.sev or N^nucl.sev.

(Verheyen et al., 1996)

Double mutant analysis suggests that nmo and fz functional synergistically in directing ommatidial rotation.

(Zheng et al., 1995)

"Nemo" is Korean for a four-sided figure.

(Choi and Benzer, 1994)

The nmo gene is required for the rotation of photoreceptor clusters in the developing eye. Mosaic analysis indicates that nmo acts within the ommatidium, suggesting local autonomy of the determination of rotation. nmo⁺ function in any photoreceptor cell is sufficient for normal rotation.

(Choi and Benzer, 1994)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 87 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38890

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0A4D6K823

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0A4D6K823

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0011817

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0011817

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38890/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011817

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

nmo_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011817

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011817

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7892

Flygut - An atlas of the Drosophila adult midgut

FBgn0011817

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0011817

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38890

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC012666

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7892

MARRVEL_MODEL - MARRVEL (model organism gene)

38890

modMine - A data warehouse for the modENCODE project

FBgn0011817

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

Q23993

Linkouts

BioGRID - A database of protein and genetic interactions.

64316

DroID - A comprehensive database of gene and protein interactions.

FBgn0011817

DRSC - Results frm RNAi screens

FBgn0011817

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0011817

FlyMine - An integrated database for Drosophila genomics

FBgn0011817

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Ca2+ pathway

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

CG7892

(Hosono et al., 2015, Garcia et al., 2013, Lotti et al., 2012, Praveen et al., 2012, Datta et al., 2011, Aerts et al., 2010, Lin et al., 2010, Ni et al., 2010.12.1, Pessa et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Perkins et al., 2009.1.15, Maia et al., 2007, Schneider et al., 2004, Morrison et al., 2000)

NEMO

(Patke et al., 2020, Dubowy and Sehgal, 2017, Merbitz-Zahradnik and Wolf, 2015, Tataroglu and Emery, 2015, Silverman et al., 2000)

NEMO/NLK

(Morrison et al., 2000)

NLK

(Ju et al., 2013, Chiu et al., 2011)

Nemo

(Strutt and Strutt, 2021, Harrison et al., 2020, Collu et al., 2018, Ishitani and Ishitani, 2013, Mbodj et al., 2013, Muñoz-Soriano et al., 2012, Zeng et al., 2002, Bessette and Verheyen, 2001, Mirkovic et al., 2001)

Nlk

(Weber et al., 2012, Whitman and Raftery, 2005, Kortenjann et al., 2001)

Nmo

(Hsiao et al., 2014, Muñoz-Soriano et al., 2012, Pessa et al., 2010, Kim et al., 2005)

ORE-6

(Maia et al., 2007)

adk

(Mirkovic et al., 1999, Verheyen et al., 1996)

adk1

(Staudt et al., 2005)

anon-EST:Gibbs3

anon-EST:Liang-2.43

anon-WO0118547.332

anon-WO0140519.256

anon-WO0172774.138

clone 2.43

(Liang and Biggin, 1998)

nemo

(Lebo et al., 2021, Ramanujam et al., 2021, Urban et al., 2017, Kallsen et al., 2015, Todd et al., 2015, Bergwitz et al., 2013, Bulgakova et al., 2012, Swaminathan et al., 2010, Wu et al., 2008, Montrasio et al., 2007)

nmo

(Joseph et al., 2022, Akai et al., 2021, Founounou et al., 2021, Kumar et al., 2021, Li et al., 2020, Wang et al., 2020, White et al., 2020, Hall et al., 2019, Hegazi et al., 2019, Takahashi et al., 2018, Bonneaud et al., 2017, Vallejos Baier et al., 2017, Blick et al., 2016, Dollar et al., 2016, Jungreis et al., 2016, Kockel et al., 2016, Schwartz et al., 2016, Appel et al., 2015, Duff et al., 2015, Gene Disruption Project members, 2015-, Todd et al., 2015, Fernandes et al., 2014, Gersten et al., 2014, Mahesh et al., 2014, Sass and Ostrow, 2014, Sopko et al., 2014, Garcia et al., 2013, Ju et al., 2013, Muñoz-Soriano et al., 2013, Gurudatta et al., 2012, Morillo et al., 2012, Muñoz-Soriano et al., 2012, Spokony and White, 2012.5.22, Weber et al., 2012, Abruzzi et al., 2011, Chiu et al., 2011, Datta et al., 2011, Hilgers et al., 2011, Mirkovic et al., 2011, Mirkovic et al., 2011, Toku et al., 2011, Aerts et al., 2010, Braid et al., 2010, Garelli, 2010.8.20, Kim et al., 2010, Dworkin et al., 2009, Lee et al., 2009, Merino et al., 2009, Shen et al., 2009, Braid and Verheyen, 2008, Fiehler and Wolff, 2008, Liu and Lehmann, 2008, Wu et al., 2008, Zeng et al., 2008, Beltran et al., 2007, Buszczak et al., 2007, Fiehler and Wolff, 2007, Kankel et al., 2007, Maia et al., 2007, Zeng et al., 2007, Badal et al., 2006, Mirkovic and Mlodzik, 2006, Gurunathan et al., 2004)

Name Synonyms

NEMO

(Chiu et al., 2011)

Nemo

(Morillo et al., 2012, Shen et al., 2009, Fiehler and Wolff, 2008, Fanto and McNeill, 2004)

Nemo-like kinase

(Sass and Ostrow, 2014, Ju et al., 2013)

adirondack

(Verheyen et al., 1996)

dNEMO

(Akira et al., 2006)

Secondary FlyBase IDs

FBgn0014365
FBgn0019910
FBgn0023460
FBgn0044612
FBgn0046458
FBgn0062087

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

References (225)

The following external sites may use different assemblies or annotations than FlyBase.

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