FB2020_05, released Oct 14, 2020

Gene: Dmel\nmo

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General Information
Symbol
Dmel\nmo
Species
D. melanogaster
Name
nemo
Annotation Symbol
CG7892
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011817
Gene Model Status
Current
Stock Availability
28 publicly available
Enzyme Name (EC)
Mitogen-activated protein kinase (2.7.11.24)
Gene Snapshot
nemo (nmo) encodes an atypical proline-directed serine/threonine kinase with roles in numerous developmental processes, including ommatidial rotation/planar cell polarity, retinal specification and neuronal function, and circadian clock speed. It regulates the activity of several signal transduction pathways, including BMP, Wnt, and Notch, and is implicated in fly models of neurodegenerative diseases. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

adk, Nlk, adirondack, Nemo-like kinase

Key Links
Genomic Location
Cytogenetic map
66A22-66B3
Sequence location
3L:7,979,046..8,054,147 [+]
Recombination map

3-21

RefSeq locus
NT_037436 REGION:7979046..8054147
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (18 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
protein kinase activity
inferred from direct assay
(Zeng et al., 2007)
protein serine/threonine kinase activity
inferred from direct assay
(Collu et al., 2018, Morillo et al., 2012, Mirkovic et al., 2011)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
ATP binding
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
MAP kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000622075
(assigned by GO_Central )
(Gaudet et al., 2011)
protein serine/threonine kinase activity
inferred from sequence or structural similarity
(Choi and Benzer, 1994)
Biological Process (12 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
compound eye development
inferred from mutant phenotype
(Choi and Benzer, 1994)
gravitaxis
inferred from mutant phenotype
(Toma et al., 2002)
imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Verheyen et al., 2001)
imaginal disc-derived wing vein specification
inferred from mutant phenotype
(Verheyen et al., 2001)
negative regulation of canonical Wnt signaling pathway
inferred from genetic interaction with FLYBASE:arm; FB:FBgn0000117
(Zeng and Verheyen, 2004)
inferred from genetic interaction with FLYBASE:sgg; FB:FBgn0003371
(Zeng and Verheyen, 2004)
inferred from genetic interaction with FLYBASE:fz2; FB:FBgn0016797
(Zeng and Verheyen, 2004)
inferred from genetic interaction with FLYBASE:Axn; FB:FBgn0026597
(Zeng and Verheyen, 2004)
ommatidial rotation
inferred from mutant phenotype
(Muñoz-Soriano et al., 2013, Fiehler and Wolff, 2008, Chou and Chien, 2002)
positive regulation of synaptic growth at neuromuscular junction
inferred from mutant phenotype
(Merino et al., 2009)
protein autophosphorylation
inferred from direct assay
(Morillo et al., 2012)
regulation of establishment of planar polarity
inferred from genetic interaction with FLYBASE:pk; FB:FBgn0003090, FLYBASE:Vang; FB:FBgn0015838
(Mirkovic et al., 2011)
inferred from genetic interaction with FLYBASE:gish; FB:FBgn0250823
(Weber et al., 2012)
inferred from genetic interaction with FLYBASE:pk; FB:FBgn0003090
(Collu et al., 2018)
inferred from genetic interaction with FLYBASE:fz; FB:FBgn0001085
(Zheng et al., 1995)
wing disc dorsal/ventral pattern formation
inferred from mutant phenotype
(Zeng and Verheyen, 2004)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
intracellular signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000622075
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of gene expression
inferred from biological aspect of ancestor with PANTHER:PTN000622075
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
cytoplasm
inferred from biological aspect of ancestor with PANTHER:PTN000622075
(assigned by GO_Central )
(Gaudet et al., 2011)
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000622075
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with MGI:MGI:1201387
(FlyBase Curators, 2008--)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + a protein = ADP + a phosphoprotein (2.7.11.24)
Summaries
Gene Group (FlyBase)
ATYPICAL MITOGEN ACTIVATED PROTEIN KINASES -
Atypical Mitogen-activated protein kinases are proline-directed serine/threonine kinases that share significant sequence homology with the kinase domain of conventional MAPKs. They are not part of the conventional MAPK cascade and differ in key residues of the activation loop. (Adapted from PMID:21372320).
Pathway (FlyBase)
Negative Regulators of Wnt-TCF Signaling Pathway -
Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
Summary (Interactive Fly)

protein serine/threonine kinase involved in establishing ommatidial rotation/planar cell polarity, retinal specification and neuronal function, and circadian clock speed - regulates the activity of several signal transduction pathways, including BMP, Wnt, and Notch - implicated in fly models of neurodegenerative diseases

Gene Model and Products
Number of Transcripts
8
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\nmo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Stage-specific extension of 3' UTRs observed during embryogenesis (FBrf0215804); all variants may not be annotated.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

gene_with_stop_codon_read_through ; SO:0000697

Stop-codon suppression (UGA) postulated; FBrf0234051.

Gene model reviewed during 6.25

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2016)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
nmo-RA
FBtr0076754
NM_168251
5131
414
nmo-RB
FBtr0076755
NM_168252
3131
414
nmo-RC
FBtr0076757
NM_079243
2624
414
nmo-RE
FBtr0076756
NM_168248
2421
430
nmo-RF
FBtr0076758
NM_168249
2757
430
nmo-RG
FBtr0076759
NM_168250
2250
430
nmo-RH
FBtr0333223
NM_001274626
6235
430
nmo-RI
FBtr0474156
NM_001370048
2250
439
Additional Transcript Data and Comments
Reported size (kB)

7.6, 7.2, 5.8, 5.4, 4.6, 4.1, 3.6, 3.2 (northern blot)

(Choi and Benzer, 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
nmo-PA
FBpp0076471
46.4
414
7.93
NP_729319
AAF50497
nmo-PB
FBpp0076472
46.4
414
7.93
NP_729320
AAN12038
nmo-PC
FBpp0076474
46.4
414
7.93
NP_523967
AAN12039
nmo-PE
FBpp0076473
48.2
430
7.61
NP_729316
AAN12035
nmo-PF
FBpp0076475
48.2
430
7.61
NP_729317
AAN12036
nmo-PG
FBpp0076476
48.2
430
7.61
NP_729318
AAN12037
nmo-PH
FBpp0305425
48.2
430
7.61
NP_001261555
AGB94250
nmo-PI
FBpp0423155
49.1
439
7.61
QCD26219
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

414 aa isoforms: nmo-PA, nmo-PB, nmo-PC
430 aa isoforms: nmo-PE, nmo-PF, nmo-PG, nmo-PH
Additional Polypeptide Data and Comments
Reported size (kDa)

477, 434 (aa)

(Choi and Benzer, 1994)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nmo using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Choi and Benzer, 1994)
third instar larval stage
morphogenetic furrow
(Choi and Benzer, 1994)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
pupal stage P6
wing cell

Comment: 25-30 hr APF; expression is enriched immediately adjacent to wing veins

(Verheyen et al., 2001)
embryonic stage 4 -- 5
organism | ubiquitous

Comment: maternally deposited

(Verheyen et al., 2001)
embryonic stage 6 -- 10
somatic cell

Comment: zygotic expression in most cells

(Verheyen et al., 2001)
embryonic stage 9 -- 12
organism | segmentally repeated
(Verheyen et al., 2001)
embryonic segment | anterior

Comment: expression is in denticle-secreting cells

(Verheyen et al., 2001)
embryonic stage 11 -- 17
presumptive embryonic/larval central nervous system
(Verheyen et al., 2001)
embryonic stage 10 -- 13
tracheal pit
(Verheyen et al., 2001)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic head epidermis
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
embryonic optic lobe primordium
(Fisher et al., 2012)
larval stage
eye disc posterior to the morphogenetic furrow

Comment: narrow stripe

(Choi and Benzer, 1994)
eye disc | ubiquitous

Comment: low level, isoform-specific

(Choi and Benzer, 1994)
embryonic stage 9 -- 17
organism

Comment: extended 3' UTR isoform

(Hilgers et al., 2011)
Additional Descriptive Data

Isoforms of nmo with extended 3' UTRs appear later in embryogenesis. Sequential, phased, 3' UTR lengthening is seen (3' UTR lengthening ocurring in multiple steps during later stages of embryogenesis).

(Hilgers et al., 2011)

One nmo isoform is expressed in a stripe posterior the morphogenetic furrow. The other is expressed at low levels throughout the disc.

(Ma and Moses, 1995)

nmo transcripts are expressed in a complex pattern throughout development. Six transcripts are expressed in early embryos, (3.2, 3.6, 4.1, 4.6, 5.4, and 5.8 kb). A 7.2kb transcript appears in late embryos and a 7.6kb transcript is detected in adult heads. The seven transcripts are all developmentally regulated with varying patterns. In general, transcription is highest in embryos, third instar larvae, and pupae.

(Choi and Benzer, 1994)

nmo transcripts are detected close to the morphogenetic furrow in third instar eye discs.

(Choi and Benzer, 1994)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: Mi{Trojan-GAL4.2}nmoMI03101-TG4.2
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | restricted
(Lee et al., 2018)
adult mushroom body
(Lee et al., 2018)
Reporter: P{lacW}nmoP1
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
photoreceptor cell | presumptive
(Choi and Benzer, 1994)
morphogenetic furrow
(Braid and Verheyen, 2008, Choi and Benzer, 1994)
eye disc posterior to the morphogenetic furrow
(Braid and Verheyen, 2008)
presumptive ocellus
(Braid and Verheyen, 2008)
presumptive third segment of antenna
(Braid and Verheyen, 2008)
second instar larval stage
eye disc
(Braid and Verheyen, 2008)
embryonic stage
ventral nerve cord
(Merino et al., 2009)
embryonic stage 5
organism | ubiquitous
(Braid et al., 2010)
embryonic stage 6 -- 11
organism | restricted
(Braid et al., 2010)
embryonic stage 15
organism | restricted

Comment: segment boundaries

(Braid et al., 2010)
adult stage
s-LNv neuron | subset
(Yu et al., 2011)
l-LNv neuron | subset
(Yu et al., 2011)
LNd neuron | subset
(Yu et al., 2011)
DN1 neuron
(Yu et al., 2011)
embryonic stage 6
organism | restricted
(Braid et al., 2010)
embryonic stage 7 -- 14
organism | segment polarity expression pattern
(Braid et al., 2010)
third instar larval stage
eye disc posterior to the morphogenetic furrow
(Choi and Benzer, 1994)
Reporter: P{ST.lexA::HG}nmoFW-1
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
embryonic/larval central nervous system
(Bloomington Drosophila Stock Center, 2019)
ventral nerve cord
(Bloomington Drosophila Stock Center, 2019)
larval insulin secreting cell of pars intercerebralis
(Bloomington Drosophila Stock Center, 2019)
embryonic/larval midgut
(Bloomington Drosophila Stock Center, 2019)
embryonic/larval fat body
(Bloomington Drosophila Stock Center, 2019)
embryonic/larval salivary gland
(Bloomington Drosophila Stock Center, 2019)
Reporter: PBac{810.P.FSVS-2}nmoCPTI004543
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\nmo in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 41 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 18 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of nmo
Transgenic constructs containing regulatory region of nmo
Deletions and Duplications ( 5 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal - all die before end of embryonic stage, with Scer\GAL469B
lethal - all die before end of embryonic stage | germline clone | maternal effect
lethal - all die before end of P-stage
partially lethal - majority die | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
female semi-sterile, with Scer\GAL4VP16.mat.αTub67C
fertile
Other Phenotypes
Allele
behavior defective | dominant
cell death defective, with Scer\GAL469B
cell polarity defective
circadian rhythm defective | adult stage, with Scer\GAL4P2.4.Pdf
circadian rhythm defective | adult stage, with Scer\GAL4tim.PU
circadian rhythm defective | adult stage (with Df(3L)Exel6279)
decreased cell size (with nmoadk2)
decreased cell size (with nmoDB24)
gravitaxis defective
locomotor rhythm defective, with Scer\GAL4tim.UAS
neuroanatomy defective | third instar larval stage
neuroanatomy defective | third instar larval stage, with Scer\GAL4G14
neuroanatomy defective | third instar larval stage (with Df(3L)Exel6279)
neuroanatomy defective | third instar larval stage (with Df(3L)pbl-X1)
neuroanatomy defective | third instar larval stage (with nmoDB24)
neuroanatomy defective | third instar larval stage (with nmoP1)
planar polarity defective
planar polarity defective, with Scer\GAL469B
planar polarity defective, with Scer\GAL4bs-1348
planar polarity defective, with Scer\GAL4hs.2sev
planar polarity defective (with nmoj147-1)
planar polarity defective (with nmoP1)
planar polarity defective | recessive
planar polarity defective | somatic clone | third instar larval stage
some die during embryonic stage, with Scer\GAL469B
some die during embryonic stage | germline clone | maternal effect | maternal effect
some die during pharate adult stage
visible
visible, with Scer\GAL432B
visible, with Scer\GAL469B
visible, with Scer\GAL4bi.PU
visible (with nmoadk2)
visible (with nmoDB24)
visible (with nmoP1)
visible | recessive
Phenotype manifest in
Allele
abdominal tergite & macrochaeta, with Scer\GAL469B
abdominal tergite & microchaeta, with Scer\GAL469B
cone cell
crossvein | ectopic
denticle, with Scer\GAL469B
denticle | germline clone | maternal effect
denticle belt, with Scer\GAL469B
denticle belt | germline clone | maternal effect
embryo | dorsal closure stage, with Scer\GAL469B
embryonic/first instar larval cuticle, with Scer\GAL469B
embryonic/first instar larval cuticle | germline clone | maternal effect
embryonic head, with Scer\GAL469B
embryonic head | germline clone | maternal effect
embryonic segment | germline clone | maternal effect
eye
eye, with Scer\GAL4GMR.PU
eye, with Scer\GAL4hs.2sev
eye (with nmoadk2)
eye (with nmoP1)
eye disc
head bristle
interommatidial bristle
mesothoracic tergum & macrochaeta
NMJ bouton | third instar larval stage
NMJ bouton | third instar larval stage, with Scer\GAL4G14
NMJ bouton | third instar larval stage (with Df(3L)Exel6279)
NMJ bouton | third instar larval stage (with Df(3L)pbl-X1)
NMJ bouton | third instar larval stage (with nmoDB24)
NMJ bouton | third instar larval stage (with nmoP1)
ommatidial precursor cluster
ommatidial precursor cluster | somatic clone
ommatidium
ommatidium, with Scer\GAL4GMR.PU
ommatidium, with Scer\GAL4hs.2sev
ommatidium (with nmoadk2)
ommatidium (with nmoj147-1)
ommatidium (with nmoP1)
ommatidium | somatic clone
posterior crossvein, with Scer\GAL432B
posterior crossvein, with Scer\GAL469B
posterior crossvein, with Scer\GAL4bi.PU
scutellar bristle, with Scer\GAL4ap-md544
scutum & macrochaeta, with Scer\GAL4ap-md544
secondary pigment cell
secondary pigment cell | ectopic
submarginal cell, with Scer\GAL4bi.PU
tertiary pigment cell | ectopic
type I bouton | third instar larval stage (with Df(3L)Exel6279)
wing
wing, with Scer\GAL469B
wing, with Scer\GAL4ap-md544
wing, with Scer\GAL4bi.PU
wing | anterior, with Scer\GAL469B
wing blade
wing blade, with Scer\GAL469B
wing blade (with nmoadk2)
wing blade (with nmoDB24)
wing cell, with Scer\GAL4bi.PU
wing margin, with Scer\GAL4sd-SG29.1
wing vein, with Scer\GAL4bi.PU
wing vein | ectopic
wing vein | ectopic, with Scer\GAL469B
wing vein | ectopic (with nmoadk2)
wing vein | ectopic (with nmoDB24)
wing vein L2, with Scer\GAL469B
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (15)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\NLK
14 of 15
Yes
Yes
2  
Hsap\MAPK3
2 of 15
No
No
2  
Hsap\MAPK8
2 of 15
No
No
1  
Hsap\MAPK9
2 of 15
No
No
Hsap\MAPK10
2 of 15
No
No
1  
Hsap\ICK
1 of 15
No
No
Hsap\MAPK1
1 of 15
No
No
Hsap\MAPK4
1 of 15
No
No
Hsap\MAPK6
1 of 15
No
No
Hsap\MAPK7
1 of 15
No
No
Hsap\MAPK12
1 of 15
No
No
Hsap\MAPK13
1 of 15
No
No
1  
Hsap\MAPK15
1 of 15
No
No
Hsap\SRPK2
1 of 15
No
No
Hsap\SRPK3
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (15)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Nlk
14 of 15
Yes
Yes
Mmus\Mapk3
2 of 15
No
No
Mmus\Mapk8
2 of 15
No
No
Mmus\Mapk9
2 of 15
No
No
Mmus\Ick
1 of 15
No
No
Mmus\Mapk1
1 of 15
No
No
Mmus\Mapk4
1 of 15
No
No
Mmus\Mapk6
1 of 15
No
No
Mmus\Mapk7
1 of 15
No
No
Mmus\Mapk10
1 of 15
No
No
Mmus\Mapk12
1 of 15
No
No
Mmus\Mapk13
1 of 15
No
No
Mmus\Mapk15
1 of 15
No
No
Mmus\Srpk2
1 of 15
No
No
Mmus\Srpk3
1 of 15
No
No
Rattus norvegicus (Norway rat) (16)
Rnor\Nlk
12 of 13
Yes
Yes
Rnor\Mapk3
2 of 13
No
No
Rnor\Mapk8
2 of 13
No
No
Rnor\Mapk9
2 of 13
No
No
Rnor\Mapk10
2 of 13
No
No
Rnor\Ick
1 of 13
No
No
Rnor\LOC365949
1 of 13
No
Yes
Rnor\LOC100912585
1 of 13
No
No
Rnor\Mapk1
1 of 13
No
No
Rnor\Mapk4
1 of 13
No
No
Rnor\Mapk6
1 of 13
No
No
Rnor\Mapk12
1 of 13
No
No
Rnor\Mapk13
1 of 13
No
No
Rnor\Mapk15
1 of 13
No
No
Rnor\Srpk2
1 of 13
No
No
Rnor\Srpk3
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (15)
Xtro\nlk.2
10 of 12
Yes
Yes
Xtro\nlk
8 of 12
No
Yes
Xtro\mapk8
2 of 12
No
No
Xtro\mapk10
2 of 12
No
No
Xtro\ick
1 of 12
No
No
Xtro\LOC100144966
1 of 12
No
No
Xtro\LOC100145045
1 of 12
No
No
Xtro\mapk1
1 of 12
No
No
Xtro\mapk4
1 of 12
No
No
Xtro\mapk6
1 of 12
No
No
Xtro\mapk7
1 of 12
No
No
Xtro\mapk12
1 of 12
No
No
Xtro\mapk15
1 of 12
No
No
Xtro\srpk2
1 of 12
No
No
Xtro\srpk3
1 of 12
No
No
Danio rerio (Zebrafish) (19)
Drer\nlk2
13 of 15
Yes
Yes
Drer\nlk1
6 of 15
No
Yes
Drer\mapk3
2 of 15
No
No
Drer\mapk8a
2 of 15
No
No
Drer\mapk8b
2 of 15
No
No
Drer\mapk9
2 of 15
No
No
Drer\mapk10
2 of 15
No
No
Drer\mapk1
1 of 15
No
No
Drer\mapk4
1 of 15
No
No
Drer\mapk6
1 of 15
No
No
Drer\mapk7
1 of 15
No
No
Drer\mapk12a
1 of 15
No
No
Drer\mapk12b
1 of 15
No
No
Drer\mapk13
1 of 15
No
No
Drer\mapk15
1 of 15
No
No
Drer\si:ch211-220i18.4
1 of 15
No
No
Drer\srpk1a
1 of 15
No
No
Drer\srpk3
1 of 15
No
No
Drer\zgc:171775
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (12)
Cele\lit-1
14 of 15
Yes
Yes
Cele\C49C3.10
2 of 15
No
No
Cele\Y51B9A.9
2 of 15
No
No
Cele\F09C12.2
1 of 15
No
No
Cele\jnk-1
1 of 15
No
No
Cele\kgb-1
1 of 15
No
No
Cele\kgb-2
1 of 15
No
No
Cele\mapk-15
1 of 15
No
No
Cele\mpk-1
1 of 15
No
No
Cele\mpk-2
1 of 15
No
No
Cele\pmk-3
1 of 15
No
No
Cele\sma-5
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (20)
Atha\MPK1
3 of 9
Yes
No
Atha\MPK2
3 of 9
Yes
No
Atha\MPK7
3 of 9
Yes
No
Atha\MPK14
3 of 9
Yes
No
Atha\ATMPK13
2 of 9
No
No
Atha\MPK3
2 of 9
No
No
Atha\MPK4
2 of 9
No
No
Atha\MPK5
2 of 9
No
No
Atha\MPK6
2 of 9
No
No
Atha\MPK10
2 of 9
No
No
Atha\MPK11
2 of 9
No
No
Atha\MPK12
2 of 9
No
No
Atha\MPK19
2 of 9
No
No
Atha\ATMPK8
1 of 9
No
No
Atha\MPK9
1 of 9
No
No
Atha\MPK15
1 of 9
No
No
Atha\MPK16
1 of 9
No
No
Atha\MPK17
1 of 9
No
No
Atha\MPK18
1 of 9
No
No
Atha\MPK20
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\KDX1
1 of 15
Yes
No
Scer\SLT2
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091908YC )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00003683
Drosophila simulans
Dsim\GD14046
Drosophila sechellia
Dsec\GM25010
Drosophila erecta
Dere\GG14461
Drosophila yakuba
Dyak\GE21651
Drosophila ananassae
Dana\GF23805
Drosophila pseudoobscura pseudoobscura
Dpse\GA28383
Drosophila willistoni
Dwil\GK20588
Drosophila virilis
Dvir\GJ13897
Drosophila mojavensis
Dmoj\GI13148
Drosophila grimshawi
Dgri\GH14986
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915058H )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017070
Glossina morsitans
Tsetse fly
Gmor\GMOY008854
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12189
Mayetiola destructor
Hessian fly
Mdes\Mdes000980
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012269
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004797
Anopheles darlingi
American malaria mosquito
Adar\ADAC010094
Anopheles gambiae
Malaria mosquito
Agam\AGAP005898
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ004910
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W052U )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006623
Danaus plexippus
Monarch butterfly
Dple\DPOGS212179-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012567
Apis florea
Little honeybee
Aflo\2147492449
Apis florea
Little honeybee
Aflo\2516709076
Apis mellifera
Western honey bee
Amel\GB55855
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13944
Bombus terrestris
Buff-tailed bumblebee
Bter\15215328
Linepithema humile
Argentine ant
Lhum\LH26192
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000bcf
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG006484
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00585
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00591
Tribolium castaneum
Red flour beetle
Tcas\TC012666
Pediculus humanus
Human body louse
Phum\PHUM233790
Rhodnius prolixus
Kissing bug
Rpro\nmo
Cimex lectularius
Bed bug
Clec\CLEC005084
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003566
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18246
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04Z1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015056
Ixodes scapularis
Black-legged tick
Isca\ISCW003529
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73960.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM73778.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur38g00390
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_209828
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05X6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Nlk
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000005358
Gallus gallus
Domestic chicken
Ggal\NLK
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (10)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
bsk
3 of 10
Erk7
3 of 10
CG8565
2 of 10
CG42366
2 of 10
p38a
2 of 10
p38b
2 of 10
p38c
2 of 10
rl
2 of 10
SRPK
2 of 10
Srpk79D
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    nmoadk2
    ameliorates  olivopontocerebellar atrophy
    modeled by Hsap\ATXN182Q.UAS
    (Ju et al., 2013)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    NLK; nemo like kinase
    14 of 15
    609476
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        nmo
        enhanceable
        arm
        (Mirkovic et al., 2011)
        nmo
        enhanceable
        Axn
        (Zeng and Verheyen, 2004)
        nmo
        suppressible
        bsk
        (Fiehler and Wolff, 2008, Mirkovic et al., 2002)
        nmo
        enhanceable
        CG32373
        (Muñoz-Soriano et al., 2013)
        nmo
        enhanceable
        Clk
        (Mahesh et al., 2014)
        nmo
        enhanceable
        Dad
        (Zeng et al., 2007)
        nmo
        suppressible
        Dl
        (Verheyen et al., 2001)
        nmo
        enhanceable
        dpp
        (Verheyen et al., 2001)
        nmo
        suppressible
        E(spl)mβ-HLH
        (Verheyen et al., 2001)
        nmo
        enhanceable
        Egfr
        (Mirkovic et al., 2011)
        nmo
        suppressible
        H
        (Verheyen et al., 2001)
        nmo
        suppressible
        Jra
        (Mirkovic et al., 2002)
        nmo
        enhanceable
        miple1
        (Muñoz-Soriano et al., 2013)
        nmo
        suppressible
        msn
        (Mirkovic et al., 2002)
        nmo
        enhanceable
        mthl8
        (Muñoz-Soriano et al., 2013)
        nmo
        suppressible
        N
        (Mirkovic et al., 2011)
        nmo
        enhanceable
        net
        (Verheyen et al., 2001)
        nmo
        suppressible
        pan
        (Verheyen et al., 2001)
        nmo
        suppressible
        pk
        (Mirkovic et al., 2011)
        nmo
        enhanceable
        pk
        (Mirkovic et al., 2011)
        nmo
        enhanceable
        Ptp99A
        (Muñoz-Soriano et al., 2013)
        nmo
        enhanceable
        px
        (Verheyen et al., 2001)
        nmo
        suppressible
        sca
        (Fiehler and Wolff, 2008)
        nmo
        suppressible
        sgg
        (Zeng and Verheyen, 2004)
        nmo
        enhanceable
        shg
        (Mirkovic et al., 2011)
        nmo
        enhanceable
        spi
        (Mirkovic et al., 2011)
        nmo
        enhanceable
        Tak1
        (Mirkovic et al., 2002)
        nmo
        suppressible
        Tak1
        (Mirkovic et al., 2002)
        nmo
        suppressible
        tkv
        (Merino et al., 2009)
        nmo
        enhanceable
        unc-13-4A
        (Muñoz-Soriano et al., 2013)
        nmo
        enhanceable
        Vang
        (Mirkovic et al., 2011, Mirkovic et al., 2011)
        nmo
        suppressible
        Vang
        (Mirkovic et al., 2011)
        nmo
        suppressible
        zip
        (Fiehler and Wolff, 2008)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        aos
        suppressible
        nmo
        (Gaengel and Mlodzik, 2003)
        arm
        suppressible
        nmo
        (Zeng and Verheyen, 2004)
        Axn
        suppressible
        nmo
        (Zeng and Verheyen, 2004)
        dgo
        enhanceable
        nmo
        (Wu et al., 2008)
        Dl
        enhanceable
        nmo
        (Verheyen et al., 2001)
        ec
        suppressible
        nmo
        (Montrasio et al., 2007)
        fz2
        suppressible
        nmo
        (Zeng and Verheyen, 2004)
        gish
        suppressible
        nmo
        (Weber et al., 2012)
        H
        enhanceable
        nmo
        (Verheyen et al., 2001)
        hid
        suppressible
        nmo
        (Mirkovic et al., 2002)
        Mad
        suppressible
        nmo
        (Zeng et al., 2007)
        miple1
        enhanceable
        nmo
        (Muñoz-Soriano et al., 2013)
        N
        suppressible
        nmo
        (Verheyen et al., 1996)
        N
        enhanceable
        nmo
        (Verheyen et al., 1996)
        net
        enhanceable
        nmo
        (Verheyen et al., 2001)
        pan
        suppressible
        nmo
        (Verheyen et al., 2001)
        Pkn
        enhanceable
        nmo
        (Sass and Ostrow, 2014)
        px
        enhanceable
        nmo
        (Verheyen et al., 2001)
        Rac1
        suppressible
        nmo
        (Fanto et al., 2000)
        rpr
        suppressible
        nmo
        (Mirkovic et al., 2002)
        sca
        enhanceable
        nmo
        (Chou and Chien, 2002)
        sca
        suppressible
        nmo
        (Chou and Chien, 2002)
        Tak1
        suppressible
        nmo
        (Mihaly et al., 2001)
        tkv
        enhanceable
        nmo
        (Zeng et al., 2007)
        tkv
        suppressible
        nmo
        (Zeng et al., 2007)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Negative Regulators of Wnt-TCF Signaling Pathway -
        Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
        Metabolic Pathways
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map

        3-21

        Cytogenetic map
        66A22-66B3
        Sequence location
        3L:7,979,046..8,054,147 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        66A22-66B3
        Limits computationally determined from genome sequence between P{PZ}l(3)0721708223&P{EP}Rac2EP3118 and P{lacW}Nmtj1C7
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        66B1-66B2
        (Choi, 1994.7.7)
        66B1-66B2
        (determined by in situ hybridisation)
        (Choi and Benzer, 1994)
        Experimentally Determined Recombination Data
        Location

        3-21

        (FlyBase, 2016)

        3-18.6

        (Comeron et al., 2012)

        3-66

        (Verheyen et al., 2001)

        3-

        (Verheyen et al., 1996, Choi, 1994.7.7)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (28)
        Genomic Clones (41)
        cDNA Clones (144)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of

        Source for merge of: nmo anon- EST:Gibbs3

        (Verheyen and Artavanis-Tsakonas, 1998, FlyBase, 1996-)

        Source for merge of: nmo anon-WO0118547.332 anon-WO0140519.256

        (FlyBase, 1996-)
        Additional comments

        Source for merge of nmo anon- EST:Gibbs3 was sequence comparison ( date:030707 ).

        (Verheyen and Artavanis-Tsakonas, 1998, FlyBase, 1996-)

        Source for merge of nmo anon-WO0118547.332 anon-WO0140519.256 was sequence comparison ( date:051113 ).

        (FlyBase, 1996-)
        Other Comments

        nmo is required in the larval eye disc through most of the first 45[o] of ommatidial rotation to regulate the speed at which the ommatidial precursors move. nmo is required in photoreceptors R1, R6 and R7 for normal orientation.

        (Fiehler and Wolff, 2008)

        When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, spindle abnormalities, centrosome abnormalities, lagging chromatids and a whole range of mitotic abnormalities are seen.

        (Bettencourt-Dias et al., 2004)

        Overexpressed nmo reduces the levels of arm protein in regions where it is stabilised by wg signaling.

        (Zeng and Verheyen, 2004)

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)

        Area matching Drosophila Nemo gene, Acc. No. U12010.

        (Davies, 2001.3.15)

        Area matching Drosophila EST AA439393 (inverted).

        (Davies, 2001.3.15)

        nmo is required during wing development for wing shape and vein patterning.

        (Verheyen et al., 2001)

        Genetic interactions between nmo and other mutations implicate nmo as an antagonist of wg.

        (Verheyen et al., 2001)

        Complementation group isolated in a screen for dominant enhancers and suppressors of Nact.sev or Nnucl.sev.

        (Verheyen et al., 1996)

        Double mutant analysis suggests that nmo and fz functional synergistically in directing ommatidial rotation.

        (Zheng et al., 1995)

        "Nemo" is Korean for a four-sided figure.

        (Choi and Benzer, 1994)

        The nmo gene is required for the rotation of photoreceptor clusters in the developing eye. Mosaic analysis indicates that nmo acts within the ommatidium, suggesting local autonomy of the determination of rotation. nmo+ function in any photoreceptor cell is sufficient for normal rotation.

        (Choi and Benzer, 1994)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 83 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Synonyms and Secondary IDs (21)
        Reported As
        Symbol Synonym
        CG7892
        (Hosono et al., 2015, Garcia et al., 2013, Lotti et al., 2012, Praveen et al., 2012, Datta et al., 2011, Aerts et al., 2010, Lin et al., 2010, Ni et al., 2010.12.1, Pessa et al., 2010, Keleman et al., 2009.8.5, Perkins et al., 2009, Perkins et al., 2009.1.15, Maia et al., 2007, Schneider et al., 2004, Morrison et al., 2000)
        NEMO
        (Dubowy and Sehgal, 2017, Merbitz-Zahradnik and Wolf, 2015, Tataroglu and Emery, 2015, Silverman et al., 2000)
        NEMO/NLK
        (Morrison et al., 2000)
        NLK
        (Ju et al., 2013, Chiu et al., 2011)
        Nemo
        (Collu et al., 2018, Ishitani and Ishitani, 2013, Mbodj et al., 2013, Muñoz-Soriano et al., 2012, Zeng et al., 2002, Bessette and Verheyen, 2001, Mirkovic et al., 2001)
        Nlk
        (Weber et al., 2012, Whitman and Raftery, 2005, Kortenjann et al., 2001)
        Nmo
        (Hsiao et al., 2014, Muñoz-Soriano et al., 2012, Pessa et al., 2010, Kim et al., 2005)
        ORE-6
        (Maia et al., 2007)
        adk
        (Mirkovic et al., 1999, Verheyen et al., 1996)
        adk1
        (Staudt et al., 2005)
        anon-EST:Gibbs3
        anon-EST:Liang-2.43
        anon-WO0118547.332
        anon-WO0140519.256
        anon-WO0172774.138
        clone 2.43
        (Liang and Biggin, 1998)
        nemo
        (Urban et al., 2017, Kallsen et al., 2015, Todd et al., 2015, Bergwitz et al., 2013, Bulgakova et al., 2012, Swaminathan et al., 2010, Wu et al., 2008, Montrasio et al., 2007)
        nmo
        (White et al., 2020, Hall et al., 2019, Hegazi et al., 2019, Takahashi et al., 2018, Bonneaud et al., 2017, Vallejos Baier et al., 2017, Blick et al., 2016, Dollar et al., 2016, Jungreis et al., 2016, Kockel et al., 2016, Schwartz et al., 2016, Appel et al., 2015, Duff et al., 2015, Gene Disruption Project members, 2015-, Todd et al., 2015, Fernandes et al., 2014, Gersten et al., 2014, Mahesh et al., 2014, Sass and Ostrow, 2014, Sopko et al., 2014, Garcia et al., 2013, Ju et al., 2013, Muñoz-Soriano et al., 2013, Gurudatta et al., 2012, Morillo et al., 2012, Muñoz-Soriano et al., 2012, Spokony and White, 2012.5.22, Weber et al., 2012, Abruzzi et al., 2011, Chiu et al., 2011, Datta et al., 2011, Hilgers et al., 2011, Mirkovic et al., 2011, Mirkovic et al., 2011, Toku et al., 2011, Aerts et al., 2010, Braid et al., 2010, Garelli, 2010.8.20, Kim et al., 2010, Dworkin et al., 2009, Lee et al., 2009, Merino et al., 2009, Shen et al., 2009, Braid and Verheyen, 2008, Fiehler and Wolff, 2008, Liu and Lehmann, 2008, Wu et al., 2008, Zeng et al., 2008, Beltran et al., 2007, Buszczak et al., 2007, Fiehler and Wolff, 2007, Kankel et al., 2007, Maia et al., 2007, Zeng et al., 2007, Badal et al., 2006, Mirkovic and Mlodzik, 2006, Gurunathan et al., 2004)
        Name Synonyms
        NEMO
        (Chiu et al., 2011)
        Nemo
        (Morillo et al., 2012, Shen et al., 2009, Fiehler and Wolff, 2008, Fanto and McNeill, 2004)
        Nemo-like kinase
        (Sass and Ostrow, 2014, Ju et al., 2013)
        adirondack
        (Verheyen et al., 1996)
        dNEMO
        (Akira et al., 2006)
        nemo
        (Meltzer et al., 2019, Moon et al., 2017, Muñoz-Soriano et al., 2013, Weber et al., 2012, Braid et al., 2010, Kim et al., 2010, Lee et al., 2009, Merino et al., 2009, Braid and Verheyen, 2008, Liu and Lehmann, 2008, Wu et al., 2008, Zeng et al., 2008, Kankel et al., 2007, Montrasio et al., 2007, Zeng et al., 2007, Burnette et al., 2005, Meinertzhagen, 2000, Verheyen et al., 2000, Sawamoto et al., 1999, Gubb, 1998, Verheyen and Artavanis-Tsakonas, 1998, Strutt et al., 1997, Choi, 1994.7.7, Choi, 1994.7.7, Choi and Benzer, 1994)
        Secondary FlyBase IDs
        • FBgn0014365
        • FBgn0019910
        • FBgn0023460
        • FBgn0044612
        • FBgn0046458
        • FBgn0062087
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (205)