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Gene Dmel\Pxn

General Information
Symbol	Dmel\Pxn	Species	D. melanogaster
Name	Peroxidasin	Annotation symbol	CG12002
Feature type	protein_coding_gene	FlyBase ID	FBgn0011828
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	CT1239
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	62E7-62E7	Sequence location	3L:2,601,455..2,630,072 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Peroxidasin is referred to in FlyBase by the symbol Dmel\Pxn (CG12002, FBgn0011828). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: peroxidase activity. There is experimental evidence that it is involved in the biological process: phagocytosis; extracellular matrix organization. 11 alleles are reported. No phenotypic data is available. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Haem peroxidase; Haem peroxidase, animal; Haem peroxidase, animal, subgroup; Immunoglobulin I-set; Immunoglobulin subtype; Immunoglobulin subtype 2; Immunoglobulin-like domain; Immunoglobulin-like fold; Leucine-rich repeat, typical subtype; Leucine-rich repeat-containing N-terminal; von Willebrand factor, type C. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-18 embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, larval hindgut, adult heart, larval trachea, larval/adult carcass. Gene sequence location is 3L:2601455..2630072.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 62E7-62E7   Limits computationally determined from genome sequence between P{PZ}Spn06911 and P{PZ}l(3)0680306803
Experimentally Determined Cytological Location
Cytogenetic map Notes References 62E8-62F2     (Nelson, 1994.6.20)
Experimentally Determined Recombination Data
Location	3- (Nelson, 1994.6.20)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pxn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pxn-RA FBtr0072951  NM_079167   5134   1527 Pxn-RB FBtr0072950  NM_167957   2500   457 Pxn-RC FBtr0072952  NM_206255   5192   1527 Pxn-RD FBtr0072953  NM_206254   5204   1527 Pxn-RE FBtr0072954  NM_206253   5291   1527
Additional Transcript Data & Comments
Reported size (kB)	4.9 (compiled cDNA) (Nelson et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pxn-PA   FBpp0072828   170.5   1527   6.22     NP_523891   AAF47668 Pxn-PB   FBpp0072827   50.6   457   7.09     NP_728759   AAN11518 Pxn-PC   FBpp0089205   170.5   1527   6.22     NP_995977   AAS64946 Pxn-PD   FBpp0089215   170.5   1527   6.22     NP_995976   AAS64947 Pxn-PE   FBpp0089216   170.5   1527   6.22     NP_995975   AAS64948
Additional Polypeptide Data & Comments
Reported size (kDa)	1535 (aa); 150 (kD) (Nelson et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Leucine-rich repeat-containing N-terminal (IPR000372) von Willebrand factor, type C (IPR001007) Haem peroxidase, animal (IPR002007) Leucine-rich repeat, typical subtype (IPR003591) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Immunoglobulin-like domain (IPR007110) Haem peroxidase (IPR010255) Immunoglobulin-like fold (IPR013783) Haem peroxidase, animal, subgroup (IPR019791) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF47668   AE014296 AAN11518   AE014296 AAS64946   AE014296 AAS64947   AE014296 AAS64948   AI064192   AI108844   AI109443   AI135461   AI260511   AI292836   AI295243   AI295629   AI388144   AI390031   AI404271   AI512097   AI530910   AI531205   AI531703   AI531825   AI532178   AI532291   AI532466   AI532797   AI532799   AI532815   AI533667   AI533814   AI533894   AI534015   AI534179   AI534422   AI534664   AI534695   AI534757   AI541581   AI541701   AI542182   AI542344   AI542970   AI543529   AI543696   AI544346   AI544362   AI544408   AI546659   AW940719   AW944488   AY051536 AAK92960   AY052120 AAK93544   BF488426   BF493374   BF493375   BF497262   BG637013   BG637318   BG641051   BI141957   BI173434   BI215314   BI215507   BI633037   BI633106   BI633203   BI633629   BI633684   BI635032   BI639317   BI639838   BI640504   BI641353   BT120118   BT122158   BT125647   BX005504   BX008414   BX008448   BX015022   BX018633   BX032445   BX032790   BX042541   BX043909   BX045582   BX048973   BX051644   BX053031   BX056409   BX057196   BX062638   BX069234   CK662313   CO154269   CO264594   CO280115   CO315980   CO330907   CO337417   CZ468072   CZ468073   CZ490039   EC073251   EC215257   EC216356   EC232955   EC262437   EC267366   EL876739   EL881609   U11052 AAA61568
UniProtKB/Swiss-Prot	Q9VZZ4
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   hemocyte   (Nelson et al., 1994) embryonic stage 9 -- 10   crystal cell primordium   (Fisher et al., 2012) Comment:reported as crystal cell specific anlage head mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   garland cell primordium   (Fisher et al., 2012) plasmatocyte primordium   (Fisher et al., 2012) Comment:reported as plasmatocytes anlage posterior midgut primordium   (Fisher et al., 2012) procrystal cell   (Fisher et al., 2012) embryonic stage 13 -- 16   crystal cell   (Fisher et al., 2012) embryonic head sensory system   (Fisher et al., 2012) embryonic/larval garland cell   (Fisher et al., 2012) embryonic/larval lymph gland   (Fisher et al., 2012) plasmatocyte   (Fisher et al., 2012) larval stage   embryonic/larval fat body   (Nelson et al., 1994) gastric caecum   (Nelson et al., 1994)
Additional Descriptive Data
	Pxn is transcribed primarily in hemocytes and later in cells of the fat body. Transcription starts in the two plates of the procephalic mesoderm at stage 10. Expression in the hemocytes continues as the hemocyte population expands and spreads through the embryo until at later stages Pxn transcripts are found at sites of basement membrane formation, e.g. around the gut, nerve cord, and brain. (Nelson et al., 1994)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   • basal lamina (Nelson et al., 1994) hemocyte   (Nelson et al., 1994) embryonic stage 12 -- 17   embryonic hemocyte   (Heino et al., 2001) embryonic stage 16   embryonic hemocyte   (Yin et al., 1997) embryonic fat body   (Yin et al., 1997) ring gland   (Yin et al., 1997) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
	Pxn protein is localized to hemocytes. It is initially found in the two plates of the procephalic mesoderm at stage 10. Expression in the hemocytes continues as the hemocyte population expands and spreads through the embryo until at later stages Pxn protein is found at sites of basement membrane formation, e.g. around the gut, nerve cord, and brain. (Nelson et al., 1994)
Marker for
	embryonic hemocyte
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, larval hindgut, adult heart, larval trachea, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8    86 head, virgin 1-day female    15 head, virgin 4-day female    12 head, virgin 20-day female    9 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    47 carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8  (86) head, virgin 1-day female    15 head, virgin 4-day female    12 head, virgin 20-day female    9 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8  (47) carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8    86 head, virgin 1-day female    15 head, virgin 4-day female    12 head, virgin 20-day female    9 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    47 carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8    86 head, virgin 1-day female    15 head, virgin 4-day female    12 head, virgin 20-day female    9 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    47 carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8    86 head, virgin 1-day female    15 head, virgin 4-day female    12 head, virgin 20-day female    9 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    47 carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8  (86) head, virgin 1-day female    15 head, virgin 4-day female    12 head, virgin 20-day female    9 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8  (47) carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8    86 head, virgin 1-day female    15 head, virgin 4-day female    12 head, virgin 20-day female    9 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    47 carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    1 central nervous system, larvae L3    10 central nervous system, pupae P8    86 head, virgin 1-day female    15 head, virgin 4-day female    12 head, virgin 20-day female    9 head, mated 1-day female    12 head, mated 4-day female    12 head, mated 20-day female    10 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    16 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    2 digestive system, 1-day adult    4 digestive system, 4-day adult    3 digestive system, 20-day adult    1 fat body, larvae L3 wandering    1 fat body, white prepupae    5 fat body, pupae P8    47 carcass, larvae L3 wandering    9 carcass, 1-day adult    8 carcass, 4-day adult    5 carcass, 20-day adult    2 ovary, virgin 4-day female    1 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-18 embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    7 embryo 06-08hr    21 embryo 08-10hr    26 embryo 10-12hr    46 embryo 12-14hr    41 embryo 14-16hr    72 embryo 16-18hr    56 embryo 18-20hr    42 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    22 larva L2    28 larva L3 12hr old    31 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    15 white prepupae 24hr    27 pupae 2d postWPP    46 pupae 3d postWPP    45 pupae 4d postWPP    17 adult male 01day    18 adult male 05day    18 adult male 30day    15 adult female 01day    22 adult female 05day    7 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    7 embryo 06-08hr    21 embryo 08-10hr  26 embryo 10-12hr  (46) embryo 12-14hr  (41) embryo 14-16hr  (72) embryo 16-18hr  (56) embryo 18-20hr  (42) embryo 20-22hr    13 embryo 22-24hr    12 larva L1    22 larva L2  (28) larva L3 12hr old  (31) larva L3 puffstage 1-2  (32) larva L3 puffstage 3-6  (38) larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    15 white prepupae 24hr  (27) pupae 2d postWPP  (46) pupae 3d postWPP  (45) pupae 4d postWPP    17 adult male 01day    18 adult male 05day    18 adult male 30day    15 adult female 01day    22 adult female 05day    7 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    7 embryo 06-08hr    21 embryo 08-10hr    26 embryo 10-12hr    46 embryo 12-14hr    41 embryo 14-16hr    72 embryo 16-18hr    56 embryo 18-20hr    42 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    22 larva L2    28 larva L3 12hr old    31 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    15 white prepupae 24hr    27 pupae 2d postWPP    46 pupae 3d postWPP    45 pupae 4d postWPP    17 adult male 01day    18 adult male 05day    18 adult male 30day    15 adult female 01day    22 adult female 05day    7 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    7 embryo 06-08hr    21 embryo 08-10hr    26 embryo 10-12hr    46 embryo 12-14hr    41 embryo 14-16hr    72 embryo 16-18hr    56 embryo 18-20hr    42 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    22 larva L2    28 larva L3 12hr old    31 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    15 white prepupae 24hr    27 pupae 2d postWPP    46 pupae 3d postWPP    45 pupae 4d postWPP    17 adult male 01day    18 adult male 05day    18 adult male 30day    15 adult female 01day    22 adult female 05day    7 adult female 30day    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    7 embryo 06-08hr    21 embryo 08-10hr    26 embryo 10-12hr    46 embryo 12-14hr    41 embryo 14-16hr    72 embryo 16-18hr    56 embryo 18-20hr    42 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    22 larva L2    28 larva L3 12hr old    31 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    15 white prepupae 24hr    27 pupae 2d postWPP    46 pupae 3d postWPP    45 pupae 4d postWPP    17 adult male 01day    18 adult male 05day    18 adult male 30day    15 adult female 01day    22 adult female 05day    7 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    7 embryo 06-08hr    21 embryo 08-10hr  26 embryo 10-12hr  (46) embryo 12-14hr  (41) embryo 14-16hr  (72) embryo 16-18hr  (56) embryo 18-20hr  (42) embryo 20-22hr    13 embryo 22-24hr    12 larva L1    22 larva L2  28 larva L3 12hr old  31 larva L3 puffstage 1-2  32 larva L3 puffstage 3-6  (38) larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    15 white prepupae 24hr  27 pupae 2d postWPP  (46) pupae 3d postWPP  (45) pupae 4d postWPP    17 adult male 01day    18 adult male 05day    18 adult male 30day    15 adult female 01day    22 adult female 05day    7 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    7 embryo 06-08hr    21 embryo 08-10hr    26 embryo 10-12hr    46 embryo 12-14hr    41 embryo 14-16hr    72 embryo 16-18hr    56 embryo 18-20hr    42 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    22 larva L2    28 larva L3 12hr old    31 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    15 white prepupae 24hr    27 pupae 2d postWPP    46 pupae 3d postWPP    45 pupae 4d postWPP    17 adult male 01day    18 adult male 05day    18 adult male 30day    15 adult female 01day    22 adult female 05day    7 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    7 embryo 06-08hr    21 embryo 08-10hr    26 embryo 10-12hr    46 embryo 12-14hr    41 embryo 14-16hr    72 embryo 16-18hr    56 embryo 18-20hr    42 embryo 20-22hr    13 embryo 22-24hr    12 larva L1    22 larva L2    28 larva L3 12hr old    31 larva L3 puffstage 1-2    32 larva L3 puffstage 3-6    38 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    15 white prepupae 24hr    27 pupae 2d postWPP    46 pupae 3d postWPP    45 pupae 4d postWPP    17 adult male 01day    18 adult male 05day    18 adult male 30day    15 adult female 01day    22 adult female 05day    7 adult female 30day    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    80 Schneider line 2 Sg4    476 embryonic 1182-4H    83 embryonic GM2    14 embryonic Kc167    5 embryonic S1    48 embryonic S3    422 leg disc CME L1    599 wing disc CME-W2    315 wing disc ML-DmD8    1 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    102 wing disc ML-DmD21    15 wing disc ML-DmD32    58 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    161 ovary fGS/OSS    6 ovary OSC    2 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (80) Schneider line 2 Sg4  (476) embryonic 1182-4H  (83) embryonic GM2    14 embryonic Kc167    5 embryonic S1  (48) embryonic S3  (422) leg disc CME L1  (599) wing disc CME-W2  (315) wing disc ML-DmD8    1 wing disc ML-DmD9  (47) wing disc ML-DmD16-c3  (102) wing disc ML-DmD21    15 wing disc ML-DmD32  (58) haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1  (58) CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2  (161) ovary fGS/OSS    6 ovary OSC    2 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    80 Schneider line 2 Sg4  (476) embryonic 1182-4H    83 embryonic GM2    14 embryonic Kc167    5 embryonic S1    48 embryonic S3  (422) leg disc CME L1  (599) wing disc CME-W2  (315) wing disc ML-DmD8    1 wing disc ML-DmD9    47 wing disc ML-DmD16-c3  102 wing disc ML-DmD21    15 wing disc ML-DmD32    58 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2  (161) ovary fGS/OSS    6 ovary OSC    2 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    80 Schneider line 2 Sg4    476 embryonic 1182-4H    83 embryonic GM2    14 embryonic Kc167    5 embryonic S1    48 embryonic S3    422 leg disc CME L1    599 wing disc CME-W2    315 wing disc ML-DmD8    1 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    102 wing disc ML-DmD21    15 wing disc ML-DmD32    58 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    161 ovary fGS/OSS    6 ovary OSC    2 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    80 Schneider line 2 Sg4    476 embryonic 1182-4H    83 embryonic GM2    14 embryonic Kc167    5 embryonic S1    48 embryonic S3    422 leg disc CME L1    599 wing disc CME-W2    315 wing disc ML-DmD8    1 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    102 wing disc ML-DmD21    15 wing disc ML-DmD32    58 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    161 ovary fGS/OSS    6 ovary OSC    2 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (80) Schneider line 2 Sg4  (476) embryonic 1182-4H  (83) embryonic GM2    14 embryonic Kc167    5 embryonic S1  (48) embryonic S3  (422) leg disc CME L1  (599) wing disc CME-W2  (315) wing disc ML-DmD8    1 wing disc ML-DmD9  (47) wing disc ML-DmD16-c3  (102) wing disc ML-DmD21    15 wing disc ML-DmD32  (58) haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1  (58) CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2  (161) ovary fGS/OSS    6 ovary OSC    2 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    80 Schneider line 2 Sg4  (476) embryonic 1182-4H    83 embryonic GM2    14 embryonic Kc167    5 embryonic S1    48 embryonic S3  (422) leg disc CME L1  (599) wing disc CME-W2  (315) wing disc ML-DmD8    1 wing disc ML-DmD9    47 wing disc ML-DmD16-c3  102 wing disc ML-DmD21    15 wing disc ML-DmD32    58 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2  (161) ovary fGS/OSS    6 ovary OSC    2 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    80 Schneider line 2 Sg4    476 embryonic 1182-4H    83 embryonic GM2    14 embryonic Kc167    5 embryonic S1    48 embryonic S3    422 leg disc CME L1    599 wing disc CME-W2    315 wing disc ML-DmD8    1 wing disc ML-DmD9    47 wing disc ML-DmD16-c3    102 wing disc ML-DmD21    15 wing disc ML-DmD32    58 haltere disc ML-DmD17-c3    25 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    58 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    14 tumorous blood cells mbn2    161 ovary fGS/OSS    6 ovary OSC    2 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    8 heat shock, 4-day adult    9 Cadmium 50 mM 6 hrs, larvae L3    19 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    12 Cadmium 100 mM 48 hrs, 4-day adult    2 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    11 Zinc 4.5 mM 48 hrs, 4-day adult    4 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    14 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    11 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    7 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    9 Rotenone 2 μg 12 hrs, larvae L3    10 Rotenone 8 μg 12 hrs, larvae L3    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	BDGP expression data • GH18946 SD07234 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011828 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12002-RB;CG12002-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Pxn Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 PxnGD5987 viable Pxnf07229 Sterility Allele fertile Pxnf07229 Phenotype manifest in Allele
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Pxn Class Mutagen Stocks Known lesion Pxnf07229 piggyBac transposase 2 -- Pxnc02616 piggyBac transposase 1 -- Pxnc02657b 1 -- Pxnf06964 1 -- PxnMB00459 1 -- PxnMI01492 1 -- Pxnc01017 0 -- PxnCPTI003897 piggyBac transposase 0 Yes PxnMI04044 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pxn Class Mutagen Stocks Known lesion PxnGD5987 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes PxnKK108816 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data GAL4 construct P{Pxn-GAL4} No UAS construct P{GD5987} NA P{KK108816} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}PxnMI01492 NA Mi{MIC}PxnMI04044 NA PBac{802.P.SVS-2}PxnCPTI003897 NA PBac{PB}Pxnc01017 NA PBac{PB}Pxnc02616 NA PBac{PB}Pxnc02657b NA PBac{WH}Pxnf06964 NA PBac{WH}Pxnf07229 NA insertion of enhancer trap binary system Mi{ET1}PxnMB00459 No
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
extracellular matrix organization inferred from mutant phenotype (assigned by UniProtKB) (Nelson et al., 1994) phagocytosis inferred from mutant phenotype (assigned by UniProtKB) (Nelson et al., 1994)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
heme binding inferred from electronic annotation with InterPro:IPR002007, InterPro:IPR010255, InterPro:IPR019791 (FlyBase Curators et al., 2004-) peroxidase activity inferred from sequence or structural similarity with mouse Mpo (FlyBase, 1992-)
Biological Process
CV term Evidence References
oxidation-reduction process inferred from electronic annotation with InterPro:IPR002007, InterPro:IPR010255, InterPro:IPR019791 (FlyBase Curators et al., 2004-) response to oxidative stress inferred from electronic annotation with InterPro:IPR002007, InterPro:IPR010255, InterPro:IPR019791 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
proteinaceous extracellular matrix inferred from sequence or structural similarity (Fessler et al., 1994)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Pxn - Art2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG11714 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG11876 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG13321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG14937 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG15220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG18675 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG1889 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG2183 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG3570 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG4610 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG6330 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG6796 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG6852 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG6927 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG7164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG7339 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG7429 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG8005 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG8671 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG8993 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CG9222 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CHOp24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - CSN4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - Cpr67B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - Cyp9b2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - Ent2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - Glt experimental knowledge based (Guruharsha et al., 2011) Pxn - Gyk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - Max anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - Mpp6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - Obp49a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - Pdf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - Pi3K68D experimental knowledge based (Guruharsha et al., 2011) Pxn - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - Rcd-1r anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - Scp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - Su(var)2-10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - Tango14 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - lectin-46Cb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - shf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - swa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pxn - yellow-c anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pxn allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63831 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011828 DroID - A comprehensive database of gene and protein interactions. • FBgn0011828 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38326
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6F4SWC Dipteran inclusive ortholog search EOG69W2PB Insect inclusive ortholog search EOG6K6F05 Arthropod inclusive ortholog search EOG6J6Q5V Metazoa inclusive ortholog search EOG67DP80
Orthologs in Drosophila Species (EOG6F4SWC)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Pxn     Drosophila simulans   Dsim\GD13382 Y   Drosophila sechellia   Dsec\GM15030     Drosophila erecta   Dere\GG14508 Y   Drosophila yakuba   Dyak\GE21698 Y   Drosophila ananassae   Dana\GF10247 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11325 Y   Drosophila persimilis   Dper\GL22623 Y   Drosophila willistoni   Dwil\GK12503 Y   Drosophila virilis   Dvir\GJ12984     Drosophila mojavensis   Dmoj\GI12839 Y   Drosophila grimshawi   Dgri\GH15071 Y
Orthologs in non-Drosophila Dipterans (EOG69W2PB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000376   Anopheles gambiae Malaria mosquito  Agam\HPX4
Orthologs in non-Dipteran Insects (EOG6K6F05)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Pxn   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004690   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22403   Atta cephalotes Leafcutter ant  Acep\ACEP25018   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22621   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23241   Linepithema humile Argentine ant  Lhum\LH21085   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13058   Solenopsis invicta Red fire ant  Sinv\SINV10153   Acyrthosiphon pisum Pea aphid  Apim\ACYPI009430   Bombyx mori Silkmoth  Bmor\BGIBMGA000553   Pediculus humanus Human body louse  Phum\PHUM538080   Tribolium castaneum Red flour beetle  Tcas\Pxn
Orthologs in non-Insect Arthropods (EOG6J6Q5V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\CXCR4   Ixodes scapularis Deer tick  Isca\ISCW022537
Orthologs in non-Arthropod Metazoa (EOG67DP80)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\pxn-1   Caenorhabditis elegans Nematode  Cele\pxn-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013889gn   Danio rerio Zebrafish  Drer\ENSDARG00000012535   Danio rerio Zebrafish  Drer\mpx   Xenopus tropicalis Western clawed frog  Xtro\tpo   Xenopus tropicalis Western clawed frog  Xtro\mpo   Xenopus tropicalis Western clawed frog  Xtro\pxdn   Gallus gallus Domestic chicken  Ggal\TPO   Gallus gallus Domestic chicken  Ggal\PXDN   Gallus gallus Domestic chicken  Ggal\PXDNL   Mus musculus House mouse  Mmus\Pxdn   Mus musculus House mouse  Mmus\Tpo   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000004508   Rattus norvegicus Norway rat  Rnor\Tpo   Homo sapiens Human  Hsap\PXDN   Homo sapiens Human  Hsap\PXDNL   Homo sapiens Human  Hsap\TPO
Human Orthologs (3)
Gene OMIM HGNC Hsap\PXDN     Hsap\PXDNL     Hsap\TPO
AAA Orthologs (9) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD13382 Drosophila erecta Dere\GG14508 Drosophila yakuba Dyak\GE21698 Drosophila ananassae Dana\GF10247 Drosophila pseudoobscura pseudoobscura Dpse\GA11325 Drosophila persimilis Dper\GL22623 Drosophila willistoni Dwil\GK12503 Drosophila mojavensis Dmoj\GI12839 Drosophila grimshawi Dgri\GH15071
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	19060 w1118; PBac{WH}Pxnf07229 22805 y1 w67c23; Mi{ET1}PxnMB00459 34200 y1 w*; Mi{MIC}PxnMI01492/TM3, Sb1 Ser1
Harvard	- PBac{PB}Pxnc02616 - PBac{WH}Pxnf06964 - PBac{WH}Pxnf07229 - PBac{PB}CG13890c02657a, PBac{PB}Pxnc02657b
VDRC	v107180 P{KK108816}VIE-260B v15277 w1118 P{GD5987}v15277 v15276 w1118; P{GD5987}v15276
Genomic Clones ( 1 )
	BACR27A03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 81 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH13031 GH18946 LD40695 SD07234
Other clones	DPiM_SD07234 RT09996
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT11402 AT23703 GH04476 GH08140 GH08646 GH13241 GH15840 GH21479 GH23918 LD43814 LP04410 LP08821 LP09314 LP22415 RE16349 RE21680 RE22023 SD01680 SD01752 SD02147 SD02724 SD02941 SD03095 SD03573 SD03751 SD03993 SD04415 SD04417 SD04438 SD05566 SD05778 SD05871 SD06449 SD06712 SD06727 SD07606 SD07685 SD07764 SD08318 SD08633 SD09494 SD09849 SD10320 SD10570 SD10869 SD10893 SD10951 SD12279 SD14858 SD15260 SD15937 SD21874 SD22532 SD23394 SD24585 SD27001 SD27088 SD27222 SD27764 SD27831
Other clones	30437 39449 160239 193191 523381 569083 AT01707 EK139659 EK152636 EK263255 EK296418 EN03826 EN14519 IP06660 IP11408
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011828 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38326
Antibody Information
	polyclonal (Nelson et al., 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Pxn gene product combines peroxidase and extracellular matrix motifs. The properties and expression pattern of Pxn suggest a unique function in extracellular matrix consolidation, phagocytosis and defense. (Nelson et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079167 NM_167957 NM_206253 NM_206254 NM_206255 RefSeq (Proteins) • NP_523891 NP_728759 NP_995975 NP_995976 NP_995977 DDBJ / EMBL / GenBank • AAA61568 AAF47668 AAK92960 AAK93544 AAN11518 AAS64946 AAS64947 AAS64948 AI388144 AI534422 AW940719 AW944488 AY051536 AY052120 CZ468072 CZ468073 CZ490039 U11052 Entrez Gene - A searchable database of RefSeq genes. • 38326 UniProtKB/Swiss-Prot • Q9VZZ4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Leucine-rich repeat-containing N-terminal (IPR000372) von Willebrand factor, type C (IPR001007) Haem peroxidase, animal (IPR002007) Leucine-rich repeat, typical subtype (IPR003591) Immunoglobulin subtype 2 (IPR003598) Immunoglobulin subtype (IPR003599) Immunoglobulin-like domain (IPR007110) Haem peroxidase (IPR010255) Immunoglobulin-like fold (IPR013783) Haem peroxidase, animal, subgroup (IPR019791) Immunoglobulin I-set (IPR013098) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH18946 SD07234
Linkouts
	BioGRID - A database of protein and genetic interactions • 63831 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0011828 DroID - A comprehensive database of gene and protein interactions. • FBgn0011828 DRSC - Results from RNAi screens. • FBgn0011828 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011828 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12002-RB;CG12002-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011828 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38326 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38326 modMine - Data generated by the modENCODE project. • FBgn0011828
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG12002 (MacLaren et al., 2004, Keleman et al., 2009.8.5, Wertheim et al., 2005) CT1239 (Hynes and Zhao, 2000, Hynes and Zhao, 2000, Hynes and Zhao, 2000) DmPxd-a (Soudi et al., 2012) Dpxn (Vazquez et al., 2002) pxn (Waltzer et al., 2003, Waltzer et al., 2002, Wood et al., 2006, Shia et al., 2009, Marcu et al., 2011, Bras et al., 2012) Pxn (Stramer et al., 2005, Pezzulo et al., 2012, Bruckner et al., 2004, Sinenko et al., 2011, Stofanko et al., 2010, Grigorian et al., 2011, Blauwkamp et al., 2008, Babcock et al., 2008, Honti et al., 2010, Minakhina and Steward, 2010, Adryan et al., 2007, Wertheim et al., 2005, Bunt et al., 2010, Wasbrough et al., 2010, Bhave et al., 2012, Sinenko et al., 2010, Kelsey et al., 2012, Gurudatta et al., 2012)
Name Synonym	peroxidasin (Kramerov and Fessler, 2001, Nassif et al., 1998, Bernardoni et al., 1997, Nelson, 1994.6.20, Wood et al., 2006, Shia et al., 2009, Marcu et al., 2011, Bhave et al., 2012, Soudi et al., 2012, Bras et al., 2012, Sinenko et al., 2010) Peroxidasin (Blauwkamp et al., 2008, Babcock et al., 2008, Minakhina and Steward, 2010, Paladi and Tepass, 2004, Bunt et al., 2010) peroxydasin (Jacques et al., 2009) Protein X (Fessler et al., 1993)
Secondary FlyBase IDs
References ( 83 )
Generate a list of	All references relating to this gene ( 83 )
List References by type	Research paper  ( 48 ) Supplementary material  ( 9 ) Review  ( 4 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 8 )
	Bhave et al., 2012, Nat. Chem. Biol. 8(9): 784--790 Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis. [FBrf0219311] Bras et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(13): 4986--4991 Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis. [FBrf0217882] Gurudatta et al., 2012, Dev. Biol. 369(1): 124--132 The BEAF insulator regulates genes involved in cell polarity and neoplastic growth. [FBrf0219796] Kelsey et al., 2012, J. Cell Sci. 125(6): 1393--1400 Schnurri regulates hemocyte function to promote tissue recovery after DNA damage. [FBrf0218143] Pezzulo et al., 2012, PLoS ONE 7(8): e43777 Expression of Human Paraoxonase 1 Decreases Superoxide Levels and Alters Bacterial Colonization in the Gut of Drosophila melanogaster. [FBrf0219363] Soudi et al., 2012, Chem. Biodivers. 9(9): 1776--1793 Molecular evolution, structure, and function of peroxidasins. [FBrf0219438] Grigorian et al., 2011, Dev. Genes Evol. 221(3): 121--131 Hematopoiesis at the onset of metamorphosis: terminal differentiation and dissociation of the Drosophila lymph gland. [FBrf0214596] Marcu et al., 2011, PLoS ONE 6(1): e15361 Innate Immune Responses of Drosophila melanogaster Are Altered by Spaceflight. [FBrf0212851] Show all research papers ...
Recent reviews ( 1 )
	Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130 Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377] Show all reviews ...