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Gene Dmel\Ret

General Information
Symbol	Dmel\Ret	Species	D. melanogaster
Name	Ret oncogene	Annotation symbol	CG14396
Feature type	protein_coding_gene	FlyBase ID	FBgn0011829
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	dRet, CG1061, DmHD-59
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	39B1-39B1	Sequence location	2L:21,182,394..21,198,745 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ret oncogene is referred to in FlyBase by the symbol Dmel\Ret (CG14396, FBgn0011829). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: calcium ion binding; transmembrane receptor protein tyrosine kinase activity. Based on sequence similarity, it is predicted to be involved in the biological process: protein phosphorylation; signal transduction. 16 alleles are reported. The phenotypes of these alleles are annotated with: eye disc; eye; trichogen cell; cone cell; ommatidium. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase catalytic domain; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1622991_s_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of Ret. Gene sequence location is 2L:21182394..21198745.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 39B1-39B1   Limits computationally determined from genome sequence between P{lacW}l(2)k07215k07215&P{lacW}snRNA:U4:39Bk09410 and P{lacW}l(2)k14505k14505&P{lacW}l(2)k05106k05106
Experimentally Determined Cytological Location
Cytogenetic map Notes References 39B2-39C2     (Hahn, 2000.11.20) 39A-39A     (Huen, 1999.4.7) 39B-39B   (determined by in situ hybridisation)   (Sugaya et al., 1994)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ret for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone appears problematic (LD17515): incomplete CDS.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ret-RA FBtr0081495  NM_057696   4726   1235 Ret-RB FBtr0081494  NM_165358   4806   1235 Ret-RC FBtr0081493  NM_165359   4947   1235 Ret-RD FBtr0081492  NM_057697   5075   1237 Ret-RE FBtr0081496  NM_165360   4860   1235
Additional Transcript Data & Comments
Reported size (kB)	4.8 (northern blot) (Hahn and Bishop, 2001) 4.5 (northern blot) (Sugaya et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ret-PA   FBpp0081023   138.7   1235   6.32     NP_477044   AAF53977 Ret-PB   FBpp0081022   138.7   1235   6.32     NP_724315   AAF53978 Ret-PC   FBpp0081021   138.7   1235   6.32     NP_724316   AAN11101 Ret-PD   FBpp0081020   139.1   1237   6.21     NP_477045   AAN11103 Ret-PE   FBpp0081024   138.7   1235   6.32     NP_724317   AAN11102
Additional Polypeptide Data & Comments
Reported size (kDa)	1235 (aa) (Hahn and Bishop, 2001) 1235, 46 (aa) (Huen et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA539406   AA816386   AE014134 AAF53977   AE014134 AAF53978   AE014134 AAN11101   AE014134 AAN11102   AE014134 AAN11103   AF322652 AAK01655   AF322653 AAK01656   AI239160   AJ002914 CAA05749   AJ237969 CAC18537   AJ237969 CAC18538   AJ237970 CAB96122   AJ237971 CAB96123   AJ237972 CAB96124   AJ237973 CAB96180   AW942450   AY061231 AAL28779   BP553241   BP553242   CO187096   CO268223   CO291997   CO316501   CZ467977   CZ467978   D16401 BAA21836   EC051015   EC053523   EC054510   EC055008   EC055362   EC070911   EC201083   EC206227   EC219753   EC240866
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KT06 Q8INU0 Q7KAN0 Q9GP68 Q7KA90 Q9GP67 Q7JQD5 Q9BHA9 Q95RP6 Q9VIE4 Q7KA88
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   embryonic/larval labral segment sense organ | precursor   (Hahn and Bishop, 2001) Bolwig organ   (Hahn and Bishop, 2001) terminal organ | precursor   (Hahn and Bishop, 2001) dorsal organ | precursor   (Hahn and Bishop, 2001) embryonic stage 12   anterior midgut primordium   (Hahn and Bishop, 2001) posterior midgut primordium   (Hahn and Bishop, 2001) embryonic stage 13   ventral nerve cord | punctate & restricted   (Kallijärvi et al., 2012) third instar larval stage   ventral nerve cord | restricted   (Kallijärvi et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   embryonic/larval labral nerve | precursor   (Hahn and Bishop, 2001) embryonic stage     (Sugaya et al., 1994, Hahn and Bishop, 2001) organism | intense   (Kallijärvi et al., 2012) Comment:Transcript of 5000nt with stronger expression than 6500nt embryonic stage 5   organism | restricted   (Sugaya et al., 1994) embryonic stage 8 -- 11   yolk sac   (Hahn and Bishop, 2001) embryonic stage 11 -- 12   neuroblast | subset   (Sugaya et al., 1994) embryonic stage 12   embryonic Malpighian tubule   (Hahn and Bishop, 2001) embryonic stage 12 -- 17   embryonic stomatogastric nervous system   (Hahn and Bishop, 2001) ventral nerve cord | restricted   (Hahn and Bishop, 2001) embryonic brain | restricted   (Hahn and Bishop, 2001) embryonic stage 13   presumptive embryonic/larval peripheral nervous system | restricted   (Sugaya et al., 1994) embryonic stage 13 -- 17   midgut imaginal island   (Hahn and Bishop, 2001) ventral nerve cord | restricted   (Sugaya et al., 1994) embryonic stage 16   embryonic proventricular ganglion   (Hahn and Bishop, 2001) embryonic frontal ganglion   (Hahn and Bishop, 2001) embryonic esophageal ganglion   (Hahn and Bishop, 2001) larval stage     (Sugaya et al., 1994) third instar larval stage   eye disc | restricted   (Hahn and Bishop, 2001) organism   (Kallijärvi et al., 2012) Comment:Transcript of 5000nt with stronger expression than 6500nt pupal stage     (Sugaya et al., 1994) organism   (Kallijärvi et al., 2012) Comment:Transcript of 5000nt with stronger expression than 6500nt adult stage   organism   (Kallijärvi et al., 2012) Comment:Transcript of 5000nt with stronger expression than 6500nt adult stage & oogenesis   nurse cell   (Hahn and Bishop, 2001)
Additional Descriptive Data
	On northern blots of 0-24 hr embryos, a 4.8 kb Ret transcript is detected. In whole-mount embryos, Ret transcript is first detected in the yolk sac at the end of gastrulation. Starting at stage 12, Ret transcript is detected in the stomatogastric nervous system, in peripheral nervous system ganglia, and in the central nervous system. Expression is detected transiently in the Malpighian tubule at stage 12. Expression is detected in the anterior and posterior midgut primordia at stage 12; starting at stage 13, it becomes clear that this expression is due to the midgut imaginal islands. In the third instar larval eye-antennal imaginal disc, expression is detected in the retinal cluster near the morphogenetic furrow, and in the ocellar region. During oogenesis, expression is detected in nurse cells, but not in mature oocytes. (Hahn and Bishop, 2001) Ret transcript is detected at low levels in embryonic stages, and at very low levels in larvae and pupae. Embryonic expression is first detected after cellularization, and is transient. Expression reappears in a subset of neuroblasts at embryonic stage 11, and disappears at germ band retraction. Starting at stage 13-14, three rows of cells in the ventral nerve cord express Ret transcript. Transient expression is detected at stage 13 in some PNS cells, and some ganglial cells. (Sugaya et al., 1994) Ret transcript is expressed in small clusters of cells at the midline of the ventral neve cord segments. In third instar larva, expression is detected in a small cell cluster in the posterior ventral nerve cord. (Kallijärvi et al., 2012)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
integral to plasma membrane inferred from direct assay (Abrescia et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    55.625 Larval Midgut    45 Larval Hindgut    11.5 Larval Malpighian Tubules    23.1 Larval Fat Body    5.2 Larval Salivary Gland    9.2 Larval Trachea    14.45 Larval Carcass    19.325 Adult Head    6.2 Adult Eye    2.6 Adult Brain    15.7 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    5 Adult Midgut    4.9 Adult Hindgut    3.1 Adult Malpighian Tubules    2 Adult Fat Body    9.9 Adult Salivary Gland    7.8 Adult Heart    3.95 Adult VirginFemale Spermatheca    19.5 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    26.2 Adult Testis    3.7 Adult Male Accessory Gland    7.8 Adult Carcass    4.8 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    55.625 Larval Midgut    45 Larval Hindgut    11.5 Larval Malpighian Tubules    23.1 Larval Fat Body    5.2 Larval Salivary Gland    9.2 Larval Trachea    14.45 Larval Carcass    19.325 Adult Head    6.2 Adult Eye    2.6 Adult Brain    15.7 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    5 Adult Midgut    4.9 Adult Hindgut    3.1 Adult Malpighian Tubules    2 Adult Fat Body    9.9 Adult Salivary Gland    7.8 Adult Heart    3.95 Adult VirginFemale Spermatheca    19.5 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    26.2 Adult Testis    3.7 Adult Male Accessory Gland    7.8 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    55.625 Larval Midgut    45 Larval Hindgut    11.5 Larval Malpighian Tubules    23.1 Larval Fat Body    5.2 Larval Salivary Gland    9.2 Larval Trachea    14.45 Larval Carcass    19.325 Adult Head    6.2 Adult Eye    2.6 Adult Brain    15.7 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    5 Adult Midgut    4.9 Adult Hindgut    3.1 Adult Malpighian Tubules    2 Adult Fat Body    9.9 Adult Salivary Gland    7.8 Adult Heart    3.95 Adult VirginFemale Spermatheca    19.5 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    26.2 Adult Testis    3.7 Adult Male Accessory Gland    7.8 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    55.625 Larval Midgut    45 Larval Hindgut    11.5 Larval Malpighian Tubules    23.1 Larval Fat Body    5.2 Larval Salivary Gland    9.2 Larval Trachea    14.45 Larval Carcass    19.325 Adult Head    6.2 Adult Eye    2.6 Adult Brain    15.7 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    5 Adult Midgut    4.9 Adult Hindgut    3.1 Adult Malpighian Tubules    2 Adult Fat Body    9.9 Adult Salivary Gland    7.8 Adult Heart    3.95 Adult VirginFemale Spermatheca    19.5 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    26.2 Adult Testis    3.7 Adult Male Accessory Gland    7.8 Adult Carcass    4.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    55.625 Larval Midgut    45 Larval Hindgut    11.5 Larval Malpighian Tubules    23.1 Larval Fat Body    5.2 Larval Salivary Gland    9.2 Larval Trachea    14.45 Larval Carcass    19.325 Adult Head    6.2 Adult Eye    2.6 Adult Brain    15.7 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    5 Adult Midgut    4.9 Adult Hindgut    3.1 Adult Malpighian Tubules    2 Adult Fat Body    9.9 Adult Salivary Gland    7.8 Adult Heart    3.95 Adult VirginFemale Spermatheca    19.5 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    26.2 Adult Testis    3.7 Adult Male Accessory Gland    7.8 Adult Carcass    4.8 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    55.625 Larval Midgut    45 Larval Hindgut    11.5 Larval Malpighian Tubules    23.1 Larval Fat Body    5.2 Larval Salivary Gland    9.2 Larval Trachea    14.45 Larval Carcass    19.325 Adult Head    6.2 Adult Eye    2.6 Adult Brain    15.7 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    5 Adult Midgut    4.9 Adult Hindgut    3.1 Adult Malpighian Tubules    2 Adult Fat Body    9.9 Adult Salivary Gland    7.8 Adult Heart    3.95 Adult VirginFemale Spermatheca    19.5 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    26.2 Adult Testis    3.7 Adult Male Accessory Gland    7.8 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    55.625 Larval Midgut    45 Larval Hindgut    11.5 Larval Malpighian Tubules    23.1 Larval Fat Body    5.2 Larval Salivary Gland    9.2 Larval Trachea    14.45 Larval Carcass    19.325 Adult Head    6.2 Adult Eye    2.6 Adult Brain    15.7 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    5 Adult Midgut    4.9 Adult Hindgut    3.1 Adult Malpighian Tubules    2 Adult Fat Body    9.9 Adult Salivary Gland    7.8 Adult Heart    3.95 Adult VirginFemale Spermatheca    19.5 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    26.2 Adult Testis    3.7 Adult Male Accessory Gland    7.8 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    55.625 Larval Midgut    45 Larval Hindgut    11.5 Larval Malpighian Tubules    23.1 Larval Fat Body    5.2 Larval Salivary Gland    9.2 Larval Trachea    14.45 Larval Carcass    19.325 Adult Head    6.2 Adult Eye    2.6 Adult Brain    15.7 Adult Thoracic-Abdominal Ganglion    27.3 Adult Crop    5 Adult Midgut    4.9 Adult Hindgut    3.1 Adult Malpighian Tubules    2 Adult Fat Body    9.9 Adult Salivary Gland    7.8 Adult Heart    3.95 Adult VirginFemale Spermatheca    19.5 Adult InseminatedFemale Spermatheca    21.5 Adult Ovary    26.2 Adult Testis    3.7 Adult Male Accessory Gland    7.8 Adult Carcass    4.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    6.2   NA  Eye    2.6   NA  Brain    15.7   55.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    27.3   NA  Crop    5   45  Midgut    4.9   11.5  Hindgut    3.1   23.1  Malpighian Tubules    2   5.2  Fat Body    9.9   9.2  Salivary Gland    7.8   NA  Heart    3.95   14.45  Trachea    NA   NA  VirginFemale Spermatheca    19.5   NA  InseminatedFemale Spermatheca    21.5   NA  Ovary    26.2   NA  Testis    3.7   NA  Male Accessory Gland    7.8   19.325  Carcass    4.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    2 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    1 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    9 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    9 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    9 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    9 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    9 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    9 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    9 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    5 embryo 06-08hr    9 embryo 08-10hr    3 embryo 10-12hr    1 embryo 12-14hr    2 embryo 14-16hr    2 embryo 16-18hr    3 embryo 18-20hr    3 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    3 larva L2    1 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    4 pupae 3d postWPP    2 pupae 4d postWPP    1 adult male 01day    1 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    1 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    1 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    10 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    0 cold shock, 4-day adult    0 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    1 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    0 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    0 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    0 Caffeine 25 mg/ml 48 hrs, 4-day adult    0 Paraquat 5 mM 48 hrs, 4-day adult    0 Paraquat 10 mM 48 hrs, 4-day adult    0 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_07
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011829 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14396-RD
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 RetGD2541 RetGD14393 Other Phenotypes Allele visible RetGMR.PR RetMEN2A.GMR RetMEN2B.GMR visible, with Scer\GAL4pnr-MD237 RetGD2541 Phenotype manifest in Allele cone cell RetMEN2B.GMR eye RetGMR.PR RetMEN2A.GMR RetMEN2B.GMR eye disc RetMEN2B.GMR ommatidium RetGMR.PR RetMEN2A.GMR RetMEN2B.GMR trichogen cell, with Scer\GAL4pnr-MD237 RetGD2541
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Ret Class Mutagen Stocks Known lesion RetC168 1 -- RetMI07200 1 -- RetNP7045 1 -- Retc02477 piggyBac transposase 0 -- RetKG04135 0 --
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ret Class Mutagen Stocks Known lesion RetGD14393 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RetGD2541 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RetGD45 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes RetJF01968 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RetKK107206 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes RetGMR.PR in vitro construct - regulatory fusion 0 Yes RetMEN2A.GMR in vitro construct - amino acid replacement 0 Yes RetMEN2B.GMR in vitro construct - amino acid replacement 0 Yes RetMNPV(Op)\IE-2.PA in vitro construct - regulatory fusion 0 Yes RetScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes RetScer\UAS.T:Zzzz\FLAG,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6047 (Ryder, 2004.4.26) Df(2L)Exel9027 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD45} NA P{GD2541} NA P{GD14393} NA P{KK107206} NA P{TRiP.JF01968} NA P{UAS-Ret.3xFLAG-6xHis} NA P{UAS-Ret.L} NA characterization construct P{GMR-Ret.MEN2B} NA P{GMR-Ret.WT} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}RetNP7045 No miscellaneous insertions Mi{MIC}RetMI07200 NA P{SUPor-P}RetKG04135 NA PBac{3HPy+}RetC168 NA PBac{PB}Mcm10c01210 NA PBac{PB}Retc02477 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
integral to plasma membrane inferred from direct assay (Abrescia et al., 2005)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) calcium ion binding inferred from sequence or structural similarity with human ret proto-oncogene (Anders et al., 2001) protein tyrosine kinase activity non-traceable author statement (Oates, 1997.11.10, Morrison et al., 2000) transmembrane receptor protein tyrosine kinase activity inferred from sequence or structural similarity (Sugaya et al., 1994) inferred from sequence or structural similarity with mouse Ret (FlyBase, 1992-)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266, InterPro:IPR020635 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Sugaya et al., 1994) non-traceable author statement (Morrison et al., 2000) signal transduction inferred from sequence or structural similarity (Sugaya et al., 1994)
Cellular Component
CV term Evidence References
integral to plasma membrane inferred from sequence or structural similarity with human ret proto-oncogene (Anders et al., 2001) plasma membrane inferred from sequence or structural similarity (Sugaya et al., 1994)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ret allele Gene References unspecified bon (Read et al., 2005) bsk (Read et al., 2005) CadN2 (Read et al., 2005) Csk (Read et al., 2005) Dl (Read et al., 2005) drk (Read et al., 2005) ebi (Read et al., 2005) gl (Read et al., 2005) hh (Read et al., 2005) Jra (Read et al., 2005) kis (Read et al., 2005) ksr (Read et al., 2005) l(3)06803 (Read et al., 2005) l(3)06906 (Read et al., 2005) l(3)j2D5 (Read et al., 2005) l(3)j4B9 (Read et al., 2005) l(3)j5B6 (Read et al., 2005) l(3)S000710 (Read et al., 2005) l(3)S000718 (Read et al., 2005) l(3)S001405 (Read et al., 2005) l(3)S003704 (Read et al., 2005) l(3)S009515 (Read et al., 2005) l(3)S012805 (Read et al., 2005) l(3)S016805 (Read et al., 2005) l(3)S019203 (Read et al., 2005) l(3)S023549 (Read et al., 2005) l(3)S023708 (Read et al., 2005) l(3)S023901 (Read et al., 2005) l(3)S024329 (Read et al., 2005) l(3)S024833 (Read et al., 2005) l(3)S026238 (Read et al., 2005) l(3)S026421 (Read et al., 2005) l(3)S046604 (Read et al., 2005) l(3)S056113 (Read et al., 2005) l(3)S057101 (Read et al., 2005) l(3)S066607 (Read et al., 2005) l(3)S068808 (Read et al., 2005) l(3)S081003 (Read et al., 2005) l(3)S090114 (Read et al., 2005) l(3)S092708 (Read et al., 2005) l(3)S133117 (Read et al., 2005) l(3)S135703 (Read et al., 2005) l(3)S142909 (Read et al., 2005) Mi-2 (Read et al., 2005) Moe (Read et al., 2005) msn (Read et al., 2005) Nrg (Read et al., 2005) Pax (Read et al., 2005) Pp1-87B (Read et al., 2005) px (Read et al., 2005) Ras85D (Read et al., 2005) S (Read et al., 2005) Sin3A (Read et al., 2005) Sos (Read et al., 2005) spi (Read et al., 2005) Src42A (Read et al., 2005) Src64B (Read et al., 2005) tws (Read et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68685 DroID - A comprehensive database of gene and protein interactions. • FBgn0011829 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43875
Orthologs
OrthoDB Orthologs (65) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6KSQ45 Dipteran inclusive ortholog search EOG637RNW Insect inclusive ortholog search EOG6NK9QF Arthropod inclusive ortholog search EOG6HT772 Metazoa inclusive ortholog search EOG6C5RBD
Orthologs in Drosophila Species (EOG6KSQ45)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ret     Drosophila simulans   Dsim\GD21645 Y   Drosophila sechellia   Dsec\GM23267 Y   Drosophila erecta   Dere\GG21515 Y   Drosophila yakuba   Dyak\GE12994 Y   Drosophila ananassae   Dana\GF15151 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA12952 Y   Drosophila persimilis   Dper\GL25857 Y   Drosophila willistoni   Dwil\GK21110 Y   Drosophila virilis   Dvir\GJ19593 Y   Drosophila mojavensis   Dmoj\GI17995 Y   Drosophila grimshawi   Dgri\GH10299 Y
Orthologs in non-Drosophila Dipterans (EOG637RNW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL007123   Anopheles gambiae Malaria mosquito  Agam\AGAP008899   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000502
Orthologs in non-Dipteran Insects (EOG6NK9QF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53284   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG006960   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20270   Atta cephalotes Leafcutter ant  Acep\ACEP23828   Camponotus floridanus Florida carpenter ant  Cflo\CFLO17899   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22753   Linepithema humile Argentine ant  Lhum\LH13715   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18566   Pogonomyrmex barbatus Red harvester ant  Pbar\PB18567   Solenopsis invicta Red fire ant  Sinv\SINV15503   Solenopsis invicta Red fire ant  Sinv\SINV15485   Acyrthosiphon pisum Pea aphid  Apim\ACYPI005958   Pediculus humanus Human body louse  Phum\PHUM495270   Tribolium castaneum Red flour beetle  Tcas\ret
Orthologs in non-Insect Arthropods (EOG6HT772)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_40778   Ixodes scapularis Deer tick  Isca\ISCW003506
Orthologs in non-Arthropod Metazoa (EOG6C5RBD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\egl-15 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020677gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016716gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024883gn Y Danio rerio Zebrafish  Drer\fgfr2 Y Danio rerio Zebrafish  Drer\fgfr4 Y Danio rerio Zebrafish  Drer\fgfr1b Y Danio rerio Zebrafish  Drer\ret1 Y Danio rerio Zebrafish  Drer\fgfr3 Y Danio rerio Zebrafish  Drer\ENSDARG00000011027 Y Xenopus tropicalis Western clawed frog  Xtro\fgfr4 Y Xenopus tropicalis Western clawed frog  Xtro\fgfr3 Y Xenopus tropicalis Western clawed frog  Xtro\fgfr1 Y Xenopus tropicalis Western clawed frog  Xtro\ret Y Xenopus tropicalis Western clawed frog  Xtro\fgfr2 Y Gallus gallus Domestic chicken  Ggal\RET Y Gallus gallus Domestic chicken  Ggal\FGFR1 Y Gallus gallus Domestic chicken  Ggal\FGFR3 Y Gallus gallus Domestic chicken  Ggal\FGFR2 Y Mus musculus House mouse  Mmus\ENSMUSG00000005320 Y Mus musculus House mouse  Mmus\Fgfr1 Y Mus musculus House mouse  Mmus\Fgfr2 Y Mus musculus House mouse  Mmus\Ret Y Mus musculus House mouse  Mmus\Fgfr3 Y Rattus norvegicus Norway rat  Rnor\Fgfr3 Y Rattus norvegicus Norway rat  Rnor\Fgfr4 Y Rattus norvegicus Norway rat  Rnor\Ret Y Rattus norvegicus Norway rat  Rnor\Fgfr2 Y Rattus norvegicus Norway rat  Rnor\Fgfr1 Y Homo sapiens Human  Hsap\ENSG00000066468 Y Homo sapiens Human  Hsap\RET Y Homo sapiens Human  Hsap\FGFR3 Y Homo sapiens Human  Hsap\ENSG00000077782 Y Homo sapiens Human  Hsap\FGFR4 Y
Human Orthologs (5)
Gene OMIM HGNC Hsap\ENSG00000066468     Hsap\RET     Hsap\FGFR3     Hsap\ENSG00000077782     Hsap\FGFR4
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21645 Drosophila sechellia Dsec\GM23267 Drosophila erecta Dere\GG21515 Drosophila yakuba Dyak\GE12994 Drosophila ananassae Dana\GF15151 Drosophila pseudoobscura pseudoobscura Dpse\GA12952 Drosophila persimilis Dper\GL25857 Drosophila willistoni Dwil\GK21110 Drosophila virilis Dvir\GJ19593 Drosophila mojavensis Dmoj\GI17995 Drosophila grimshawi Dgri\GH10299
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	25948 y1 v1; P{TRiP.JF01968}attP2 43099 y1 w*; Mi{MIC}RetMI07200/SM6a 16295 y1 w1118; PBac{3HPy+}RetC168/CyO
Kyoto	105345 y* w*; P{GawB}RetNP7045 / CyO, P{UAS-lacZ.UW14}UW14
VDRC	v107648 P{KK107206}VIE-260B v842 w1118; P{GD45}v842 v843 w1118; P{GD45}v843 v12292 w1118 P{GD2541}v12292 v12116 w1118; P{GD2541}v12116 v29907 w1118; P{GD14393}v29907 v30832 w1118; P{GD14393}v30832
Genomic Clones ( 1 )
	BACR34H23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 17 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD17515
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM04061 LD01332
Other clones	71166 CK01.15A.F9 CK01.29D.A2 CK01.107D.B6 EC051015 EC053523 EC054510 EC055008 EC055362 EK026225 EK090639 EK198953 EK265108 FGM223D05
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0011829 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43875
Antibody Information
	polyclonal (Kallijärvi et al., 2012)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Ret CG1061 (Bayraktaroglu, 2000.4.13) Source for merge of: Ret CG14396 (Huen, 2000.6.29)
Additional comments	Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known. (Oates, 1997.11.10)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Ret codes for a transmembrane protein most similar in sequence to a mammalian proto-oncogene ret. Ret mRNA is transcribed in very small amounts in the embryonic, larval and pupal stages. mRNA is transiently expressed in neuroblasts in early embryos and is detected in subpopulations of differentiating PNS and CNS cells in late embryos. (Sugaya et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057696 NM_057697 NM_165358 NM_165359 NM_165360 RefSeq (Proteins) • NP_477044 NP_477045 NP_724315 NP_724316 NP_724317 DDBJ / EMBL / GenBank • AA539406 AAF53977 AAF53978 AAK01655 AAK01656 AAL28779 AAN11101 AAN11102 AAN11103 AF322652 AF322653 AJ002914 AJ237969 AJ237970 AJ237971 AJ237972 AJ237973 AW942450 AY061231 BAA21836 CAA05749 CAB96122 CAB96123 CAB96124 CAB96180 CAC18537 CAC18538 CZ467977 CZ467978 D16401 Entrez Gene - A searchable database of RefSeq genes. • 43875 UniProtKB/TrEMBL • Q7JQD5 Q7KA88 Q7KA90 Q7KAN0 Q7KT06 Q8INU0 Q9BHA9 Q9GP67 Q9GP68 Q9VIE4 Q95RP6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68685 DroID - A comprehensive database of gene and protein interactions. • FBgn0011829 DRSC - Results from RNAi screens. • FBgn0011829 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0011829 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14396-RD FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0011829 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43875 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43875 modMine - Data generated by the modENCODE project. • FBgn0011829
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	CG1061 (Hill et al., 2001, Morrison et al., 2000, ) CG14396 (Hill et al., 2001, Huen, 2000.6.29, Perkins et al., 1.15.2009, Keleman et al., 2009.8.5) DmHD-59 (Oates, 1997.11.10, Oates et al., 1998, ) DmRet (Kallijärvi et al., 2012) dRet (Read et al., 2005, Read et al., 2002, Tountas and Fortini, 2007, Aron et al., 2010, Dar et al., 2012, Fu et al., 2012) dRET (Abrescia et al., 2005) Dret (Jaaro et al., 2001, Read et al., 2000, Emori, 1993.6.7, Oates et al., 1998, Read and Cagan, 1998, Modolell, 1995, Gomez-Skarmeta et al., 1993, Sugaya et al., 1994, ) D-ret (Hahn and Bishop, 2001) DRET (Bassett et al., 1997) DRet (Fung et al., 2008) dret (Vidal et al., 2005) HD-59   MEN2 (Vidal and Cagan, 2006) RET (Vidal et al., 2005, Anders et al., 2001, Hill et al., 2001, Bakal et al., 2008) ret (Hahn and Bishop, 2001) Ret (Long et al., 2006, Bousum et al., 2008, Abramov et al., 2011, Zartman et al., 2009, Wasbrough et al., 2010) Reto
Name Synonym	Dret (Fung et al., 2008) Ret oncogene (Pawar et al., 2011, Zartman et al., 2009)
Secondary FlyBase IDs
	FBgn0022789 FBgn0032930 FBgn0032931
References ( 60 )
Generate a list of	All references relating to this gene ( 60 )
List References by type	Research paper  ( 20 ) Supplementary material  ( 7 ) Review  ( 3 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 8 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 4 ) Conference report  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Dar et al., 2012, Nature 486(7401): 80--84 Chemical genetic discovery of targets and anti-targets for cancer polypharmacology. [FBrf0218587] Fu et al., 2012, PLoS ONE 7(6): e38465 γ-H2AX Kinetics as a Novel Approach to High Content Screening for Small Molecule Radiosensitizers. [FBrf0218820] Kallijärvi et al., 2012, PLoS ONE 7(12): e51997 Characterization of Drosophila GDNF Receptor-Like and Evidence for Its Evolutionarily Conserved Interaction with Neural Cell Adhesion Molecule (NCAM)/FasII. [FBrf0220419] Abramov et al., 2011, Dokl. Biochem. Biophys. 437(1): 72--76 Genetic and molecular analysis of gene trans-inactivation caused by homologous eu-heterochromatic chromosome rearrangement in Drosophila melanogaster. [FBrf0213780] Pawar et al., 2011, J. Biomol. Screen. 16(4): 436--442 RNAi Screening of Drosophila (Sophophora) melanogaster S2 Cells for Ricin Sensitivity and Resistance. [FBrf0213418] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...