FlyBase Gene Report: Dmel\Tis11

General Information

Symbol

Dmel\Tis11

Species

D. melanogaster

Name

Tis11 zinc finger protein

Annotation Symbol

CG4070

Feature Type

protein_coding_gene

FlyBase ID

FBgn0011837

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

Tis11 zinc finger protein (Tis11) encodes a protein with three splice isoforms, all of which have the major attributes of members of the tristetraprolin (TTP) family of RNA binding and destabilizing proteins. Tis11 knockout and knock-down flies exhibit relatively minor delays in eclosion associated with accumulation of many putative mRNA targets. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

DTIS11, l(1)G0124, dTTP

Key Links

Genomic Location

Cytogenetic map

11B9-11B10

Sequence location

X:12,659,415..12,682,560 [+]

Recombination map

1-39

RefSeq locus

NC_004354 REGION:12659415..12682560

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables mRNA 3'-UTR AU-rich region binding

inferred from direct assay

(Choi et al., 2014)

enables mRNA 3'-UTR binding

inferred from direct assay

(Yeh et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables metal ion binding

inferred from electronic annotation with InterPro:IPR000571

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in 3'-UTR-mediated mRNA destabilization

inferred from direct assay

(Helfer et al., 2012)

involved_in negative regulation of gene expression

inferred from direct assay

(Yeh et al., 2012)

involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

inferred from mutant phenotype

(Choi et al., 2014)

involved_in post-transcriptional gene silencing by RNA

inferred from mutant phenotype

(Dorner et al., 2006)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from sequence or structural similarity with UniProtKB:P47973

(assigned by UniProt )

(UniProt Curators, 2002-)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Tis11 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P47980)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.50

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 6.27

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Tis11-RA

FBtr0073683

NM_078586

2157

436

Tis11-RC

FBtr0333756

NM_001272561

5015

436

Tis11-RD

FBtr0345165

NM_167333

2023

436

Additional Transcript Data and Comments

Reported size (kB)

6.0, 4, 3.0 (northern blot)

(Ma et al., 1994)

2.160 (longest cDNA)

(Warbrick and Glover, 1994)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Tis11-PA

FBpp0073516

47.2

436

7.73

NP_511141

AAF48194

Tis11-PC

FBpp0305898

47.2

436

7.73

NP_001259490

AGB95332

Tis11-PD

FBpp0311375

47.2

436

7.73

NP_727633

AAN09314

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

436 aa isoforms: Tis11-PA, Tis11-PC, Tis11-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

437 (aa)

(Ma et al., 1994)

436 (aa); 47 (kD predicted)

(Warbrick and Glover, 1994)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tis11 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tis11_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 6

organism

(Ma et al., 1994)

embryonic stage 7 -- 17

Comment: reference states >3 hr AEL

(Ma et al., 1994)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from high throughput direct assay

(Lye et al., 2014)

Expression Deduced from Reporters

Reporter: PBac{754.P.FSVS-0}Tis11^CPTI003080

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult brain cell body rind

Comment: low expression in adult brain cortex

(Knowles-Barley, 2011.8.24)

Reporter: PBac{768.FSVS-0}Tis11^CPTI003403

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult gnathal ganglion | restricted

Comment: part of adult subesophageal ganglion

(Knowles-Barley, 2011.8.24)

adult brain cell body rind

Comment: adult brain cortex, higher around central brain

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Tis11 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Tis11

View exonic expression by tissue for Dmel\Tis11

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0011837

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32222/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011837

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011837

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011837

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4070

Flygut - An atlas of the Drosophila adult midgut

FBgn0011837

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 22 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Tis11

Transgenic constructs containing regulatory region of Tis11

Aberrations (Deficiencies and Duplications) ( 7 )

Inferred from experimentation ( 7 )

Gene disrupted in

Df(1)BSC623

(Christensen et al., 2008.9.29)

Df(1)BSC624

(Cook et al., 2008.9.29)

Df(1)BSC625

(Christensen et al., 2008.9.29)

Df(1)G0124

(Mason, 2008.10.30)

Df(1)IE35

(Fedic et al., 2012.12.18)

Dp(1;Y)BSC5

(Choi et al., 2014)

Gene partially disrupted in

Df(1)G0124

(Mason, 2008.10.30)

Df(1)IE35

(Choi et al., 2014)

Df(1)SMRG-M

(Xu et al., 2019)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

Tis11^GD4498

lethal | recessive

Tis11^G0124

lethal - all die before end of larval stage

Tis11^G0124

viable

viable (with Dp(1;Y)BSC5)

Tis11^IE35

Sterility

Allele

fertile

fertile (with Dp(1;Y)BSC5)

Tis11^IE35

Other Phenotypes

Allele

abnormal developmental rate

Tis11^G1183

abnormal developmental rate (with Dp(1;Y)BSC5)

Tis11^IE35

abnormal size | somatic clone, with Scer\GAL4^Act5C.PU

Tis11^d00685

abnormal size | somatic clone, with Scer\GAL4^Tub.PU

abnormal stress response | somatic clone | conditional, with Scer\GAL4^NP5130

Tis11^{dsRNA.UAS.WIZ}

abnormal stress response | somatic clone | conditional, with Scer\GAL4^NP5130, Scer\GAL80^Su(H).GBE

Tis11^{dsRNA.UAS.WIZ}

decreased cell number | somatic clone, with Scer\GAL4^Act5C.PU

Tis11^d00685

decreased cell number | somatic clone, with Scer\GAL4^Tub.PU

Tis11^UAS.cMa

increased cell number | somatic clone, with Scer\GAL4^Tub.PU

Tis11^{dsRNA.UAS.WIZ}

increased occurrence of cell division | somatic clone | conditional, with Scer\GAL4^NP5130

Tis11^{dsRNA.UAS.WIZ}

increased occurrence of cell division | somatic clone | conditional, with Scer\GAL4^NP5130, Scer\GAL80^Su(H).GBE

Tis11^{dsRNA.UAS.WIZ}

some die during larval stage

Tis11^G0124

visible, with Scer\GAL4^GMR.PF

Tis11^UAS.Tag:FLAG

Phenotype manifest in

Allele

adult midgut | somatic clone, with Scer\GAL4^Act5C.PU

Tis11^d00685

adult midgut | somatic clone, with Scer\GAL4^Tub.PU

adult midgut | somatic clone | conditional, with Scer\GAL4^NP5130

Tis11^{dsRNA.UAS.WIZ}

adult midgut | somatic clone | conditional, with Scer\GAL4^NP5130, Scer\GAL80^Su(H).GBE

Tis11^{dsRNA.UAS.WIZ}

eye, with Scer\GAL4^GMR.PF

Tis11^UAS.Tag:FLAG

pigment cell, with Scer\GAL4^lz-gal4

Tis11^UAS.Tag:FLAG

rhabdomere, with Scer\GAL4^lz-gal4

Tis11^UAS.Tag:FLAG

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (3)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ZFP36

7 of 15

Yes

Hsap\ZFP36L1

7 of 15

Yes

Hsap\ZFP36L2

6 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Zfp36l1

8 of 15

Yes

Mmus\Zfp36

7 of 15

Yes

Mmus\Zfp36l2

6 of 15

Yes

Mmus\Zfp36l3

4 of 15

Yes

Rattus norvegicus (Norway rat) (5)

Rnor\Zfp36l2

5 of 13

Yes

Rnor\LOC100911319

4 of 13

Yes

Rnor\Zfp36l3

4 of 13

Yes

Rnor\Zfp36

4 of 13

Yes

Rnor\Zfp36l1

3 of 13

Yes

Xenopus tropicalis (Western clawed frog) (6)

Xtro\zfp36l1

7 of 12

Yes

Xtro\zfp36l2

7 of 12

Yes

Xtro\zfp36

6 of 12

Yes

Xtro\zfp36l2.1

4 of 12

Yes

Xtro\zfp36l2.2

4 of 12

Yes

Xtro\LOC734009

1 of 12

Yes

Danio rerio (Zebrafish) (7)

Drer\zfp36l1a

8 of 15

Yes

Drer\LOC100334443

7 of 15

Yes

Drer\zfp36l1b

7 of 15

Yes

Drer\zfp36l2

7 of 15

Yes

Drer\zgc:114130

6 of 15

Yes

Drer\cth1

5 of 15

Yes

Drer\zgc:162730

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (21)

Cele\ccch-1

8 of 15

Yes

Cele\moe-3

7 of 15

Yes

Cele\ccch-2

6 of 15

Yes

Cele\ccch-5

6 of 15

Yes

Cele\oma-1

6 of 15

Yes

Cele\oma-2

6 of 15

Yes

Cele\pos-1

6 of 15

Yes

Cele\Y60A9.3

6 of 15

Yes

Cele\C35D6.4

5 of 15

Yes

Cele\dct-13

5 of 15

Yes

Cele\F38C2.7

5 of 15

Yes

Cele\Y116A8C.19

5 of 15

Yes

Cele\Y116A8C.20

5 of 15

Yes

Cele\mex-5

4 of 15

Yes

Cele\gla-3

3 of 15

Yes

Cele\mex-1

3 of 15

Yes

Cele\mex-6

3 of 15

Yes

Cele\F02E11.4

1 of 15

Yes

Cele\pie-1

1 of 15

Yes

Cele\Y110A2AL.1

1 of 15

Yes

Cele\Y110A2AL.10

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (21)

Atha\AT1G66810

3 of 9

Yes

Atha\AT1G68200

2 of 9

Yes

Atha\HUA1

2 of 9

Yes

Atha\AT1G04990

1 of 9

Yes

Atha\AT1G32360

1 of 9

Yes

Atha\AT2G35430

1 of 9

Yes

Atha\AT2G47850

1 of 9

Yes

Atha\AT3G06410

1 of 9

Yes

Atha\AT3G19360

1 of 9

Yes

Atha\AT3G48440

1 of 9

Yes

Atha\AT5G18550

1 of 9

Yes

Atha\AT5G44260

1 of 9

Atha\AT5G63260

1 of 9

Yes

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

1 of 9

Yes

Atha\ZFN2

1 of 9

Yes

Atha\ZFN3

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\TIS11

9 of 15

Yes

Scer\CTH1

8 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\zfs1

5 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (0)

No records found.

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Tis11^EY09433

exacerbates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ZFP36; ZFP36 ring finger protein

7 of 15

190700

ZFP36L1; ZFP36 ring finger protein like 1

7 of 15

601064

ZFP36L2; ZFP36 ring finger protein like 2

6 of 15

612053

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

RNA-protein

Physical Interaction

Assay

References

Tis11 - CecA1

electrophoretic mobility shift assay, autoradiography, anti tag coimmunoprecipitation, quantitative reverse transcription pcr, isothermal titration calorimetry, predetermined participant

(de Toeuf et al., 2018, Lauwers et al., 2009, Wei et al., 2009)

Tis11 - Ldh

isothermal titration calorimetry, predetermined participant, electrophoretic mobility shift assay, autoradiography, anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(de Toeuf et al., 2018)

Tis11 - bnl

anti tag coimmunoprecipitation, quantitative reverse transcription pcr

(de Toeuf et al., 2018)

Tis11 - eya

pull down, anti tag western blot

(Yeh et al., 2012)

protein-protein

Physical Interaction

Assay

References

Tis11 - brat

anti tag coimmunoprecipitation, anti tag western blot

(Komori et al., 2018)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Tis11|brat

suppressible

dpn

(Komori et al., 2018)

Tis11

suppressible

Pop2

(McClelland et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

brat

enhanceable

Tis11

(Komori et al., 2018)

Pop2

suppressible

Tis11

(McClelland et al., 2017)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

58616

DroID - A comprehensive database of gene and protein interactions.

FBgn0011837

MIST (protein-protein) - An integrated Molecular Interaction Database

Tis11

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0011837

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-39

Cytogenetic map

11B9-11B10

Sequence location

X:12,659,415..12,682,560 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

11B9-11B10

Limits computationally determined from genome sequence between P{EP}CG11138^EP1313 and P{EP}EP1632&P{EP}EP1449

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

11C-11C

(determined by in situ hybridisation)

(Peter et al., 2002)

12B-12B

(Ma, 1994.8.12)

11B-11C

(determined by in situ hybridisation)

(Schäfer et al., 1999.6.15)

11B-11B

(determined by in situ hybridisation)

(Warbrick and Glover, 1994)

11B14-11B16

(determined by in situ hybridisation)

(Ma et al., 1994)

Experimentally Determined Recombination Data

Location

1-39

(FlyBase, 2016)

1-39.6

(Comeron et al., 2012)

(Ma, 1994.8.12)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

43635

w¹¹¹⁸; P{UAS-Tis11.A}2A

43326

w^* P{EP}Tis11^G1183

85398

w¹¹¹⁸ P{XP}Tis11^d00685

41427

y¹ w^* Mi{MIC}Tis11^MI05648

35434

y¹ sc^* v¹ sev²¹; P{TRiP.GL00358}attP2

66340

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06277}attP2

Kyoto

115403

w¹¹¹⁸ PBac{768.FSVS-0}Tis11^CPTI003403

115350

w¹¹¹⁸ PBac{754.P.FSVS-0}Tis11^CPTI003080

104113

y^* w^* P{GawB}Tis11^NP2169 / FM7c

111839

w^67c23 P{lacW}G0124 P{neoFRT}19A/FM7c; P{ey-FLP.N}5

VDRC

v101765

P{KK109451}VIE-260B

v12259

w¹¹¹⁸; P{GD4498}v12259

More stocks available...

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (422)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0011837

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0011837

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32222

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Choi et al., 2014, Lauwers et al., 2009)

monoclonal

(Ngoc et al., 2014, Twyffels et al., 2013)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: Tis11 l(1)G0124

(Peter et al., 2002)

Additional comments

Tis11 complements the temperature-sensitive phenotype of the S.pombe cdr1-34 cdc25-22 double mutant, but does not complement the cell division phenotype of the cdc25-22 single mutant strain and does not affect the length of the cell at division in the cdr1-34 single mutant strain.

(Warbrick and Glover, 1994)

Other Comments

Tis11 has been cloned from a Drosophila eye disc cDNA library.

(Ma et al., 1994)

Tis11 has been cloned and sequenced.

(Warbrick and Glover, 1994)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 56 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32222

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P47980

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P47980

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

B3DN56

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P47980

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0011837

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0011837

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32222/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0011837

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Tis11_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0011837

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0011837

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG4070

Flygut - An atlas of the Drosophila adult midgut

FBgn0011837

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0011837

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32222

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032794

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG4070

MARRVEL_MODEL - MARRVEL (model organism gene)

32222

modMine - A data warehouse for the modENCODE project

FBgn0011837

Linkouts

BioGRID - A database of protein and genetic interactions.

58616

DroID - A comprehensive database of gene and protein interactions.

FBgn0011837

DRSC - Results frm RNAi screens

FBgn0011837

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0011837

FlyMine - An integrated database for Drosophila genomics

FBgn0011837

MIST (protein-protein) - An integrated Molecular Interaction Database

Tis11

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA

Synonyms and Secondary IDs (18)

Reported As

Symbol Synonym

CG4070

(Ni et al., 2011.7.19, Gruber and Long, 2009, Keleman et al., 2009.8.5, Perkins et al., 2009, Quinones-Coello, 2007)

DTIS11

(Xu et al., 2019, Yeh et al., 2012, Liang and Biggin, 1998, Ma, 1994.8.12, Ma et al., 1994)

DTIS11-RC

(Xu et al., 2019)

TIS11

(Ma and Mayr, 2018, Temme et al., 2014, Lauwers et al., 2009, Fedic et al., 2007)

TIS11cc1

(Warbrick and Glover, 1994)

TIScc1

(Warbrick, 1994.8.22)

Ts11

(Wilson et al., 2013)

anon-EST:Liang-1.28

clone 1.28

(Liang and Biggin, 1998)

dTIS11

(Twyffels et al., 2013)

dTTP

(Vanzo et al., 2007, Jing et al., 2005)

dTis11

(Choi et al., 2014, Jing et al., 2005)

l(1)G0124

(Schäfer et al., 1999.6.15)

tis-11

(Helfer et al., 2012)

tis11

(Komori et al., 2018)

Name Synonyms

Tis11 homolog

Tis11 zinc finger protein

Secondary FlyBase IDs

FBgn0063277
FBgn0027302

Datasets (8)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (8)

Result

Result Type

Title

scRNAseq_2020_Cattenoz_NI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from non-infested third instar larvae

scRNAseq_2020_Cattenoz_WI_seq_clustering

cell clustering analysis

Clustering analysis of hemocytes from wasp-infested third instar larvae

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (82)

The following external sites may use different assemblies or annotations than FlyBase.

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