FB2021_02, released April 13, 2021

Gene: Dmel\Tis11

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General Information
Symbol
Dmel\Tis11
Species
D. melanogaster
Name
Tis11 zinc finger protein
Annotation Symbol
CG4070
Feature Type
protein_coding_gene
FlyBase ID
FBgn0011837
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Summary
Tis11 zinc finger protein (Tis11) encodes a protein with three splice isoforms, all of which have the major attributes of members of the tristetraprolin (TTP) family of RNA binding and destabilizing proteins. Tis11 knockout and knock-down flies exhibit relatively minor delays in eclosion associated with accumulation of many putative mRNA targets. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
All Summaries
Also Known As

DTIS11, l(1)G0124, dTTP

Key Links
Genomic Location
Cytogenetic map
11B9-11B10
Sequence location
X:12,659,415..12,682,560 [+]
Recombination map
1-39
RefSeq locus
NC_004354 REGION:12659415..12682560
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables mRNA 3'-UTR AU-rich region binding
inferred from direct assay
(Choi et al., 2014)
enables mRNA 3'-UTR binding
inferred from direct assay
(Yeh et al., 2012)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables metal ion binding
inferred from electronic annotation with InterPro:IPR000571
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in 3'-UTR-mediated mRNA destabilization
inferred from direct assay
(Helfer et al., 2012)
involved_in negative regulation of gene expression
inferred from direct assay
(Yeh et al., 2012)
involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
inferred from mutant phenotype
(Choi et al., 2014)
involved_in RNA interference
inferred from mutant phenotype
(Dorner et al., 2006)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from sequence or structural similarity with UniProtKB:P47973
(assigned by UniProt )
(UniProt Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Tis11 zinc finger protein (Tis11) encodes a protein with three splice isoforms, all of which have the major attributes of members of the tristetraprolin (TTP) family of RNA binding and destabilizing proteins. Tis11 knockout and knock-down flies exhibit relatively minor delays in eclosion associated with accumulation of many putative mRNA targets. [Date last reviewed: 2019-03-14]
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Tis11 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.55

Gene model reviewed during 5.50

Gene model reviewed during 5.46

Low-frequency RNA-Seq exon junction(s) not annotated.

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Gene model reviewed during 6.27

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Tis11-RA
FBtr0073683
NM_078586
2157
436
Tis11-RC
FBtr0333756
NM_001272561
5015
436
Tis11-RD
FBtr0345165
NM_167333
2023
436
Additional Transcript Data and Comments
Reported size (kB)

6.0, 4, 3.0 (northern blot)

(Ma et al., 1994)

2.160 (longest cDNA)

(Warbrick and Glover, 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Tis11-PA
FBpp0073516
47.2
436
7.73
NP_511141
AAF48194
Tis11-PC
FBpp0305898
47.2
436
7.73
NP_001259490
AGB95332
Tis11-PD
FBpp0311375
47.2
436
7.73
NP_727633
AAN09314
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

436 aa isoforms: Tis11-PA, Tis11-PC, Tis11-PD
Additional Polypeptide Data and Comments
Reported size (kDa)

437 (aa)

(Ma et al., 1994)

436 (aa); 47 (kD predicted)

(Warbrick and Glover, 1994)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Tis11 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 6
organism
(Ma et al., 1994)
embryonic stage 7 -- 17

Comment: reference states >3 hr AEL

(Ma et al., 1994)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from high throughput direct assay
(Lye et al., 2014)
Expression Deduced from Reporters
Reporter: PBac{754.P.FSVS-0}Tis11CPTI003080
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind

Comment: low expression in adult brain cortex

(Knowles-Barley, 2011.8.24)
Reporter: PBac{768.FSVS-0}Tis11CPTI003403
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult gnathal ganglion | restricted

Comment: part of adult subesophageal ganglion

(Knowles-Barley, 2011.8.24)
adult brain cell body rind

Comment: adult brain cortex, higher around central brain

(Knowles-Barley, 2011.8.24)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Tis11 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 21 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Tis11
Transgenic constructs containing regulatory region of Tis11
Aberrations (Deficiencies and Duplications) ( 7 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4pnr-MD237
lethal | recessive
lethal - all die before end of larval stage
viable
viable (with Dp(1;Y)BSC5)
Sterility
Allele
fertile
fertile (with Dp(1;Y)BSC5)
Other Phenotypes
Allele
abnormal developmental rate
abnormal developmental rate (with Dp(1;Y)BSC5)
abnormal size | somatic clone, with Scer\GAL4Act5C.PU
abnormal size | somatic clone, with Scer\GAL4Tub.PU
abnormal stress response | somatic clone | conditional, with Scer\GAL4NP5130
abnormal stress response | somatic clone | conditional, with Scer\GAL4NP5130, Scer\GAL80Su(H).GBE
decreased cell number | somatic clone, with Scer\GAL4Act5C.PU
decreased cell number | somatic clone, with Scer\GAL4Tub.PU
increased cell number | somatic clone, with Scer\GAL4Tub.PU
increased occurrence of cell division | somatic clone | conditional, with Scer\GAL4NP5130
increased occurrence of cell division | somatic clone | conditional, with Scer\GAL4NP5130, Scer\GAL80Su(H).GBE
some die during larval stage
visible, with Scer\GAL4GMR.PF
Phenotype manifest in
Allele
adult midgut | somatic clone, with Scer\GAL4Act5C.PU
adult midgut | somatic clone, with Scer\GAL4Tub.PU
adult midgut | somatic clone | conditional, with Scer\GAL4NP5130
adult midgut | somatic clone | conditional, with Scer\GAL4NP5130, Scer\GAL80Su(H).GBE
eye, with Scer\GAL4GMR.PF
retinal pigment cell, with Scer\GAL4lz-gal4
rhabdomere, with Scer\GAL4lz-gal4
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ZFP36
7 of 15
Yes
Yes
Hsap\ZFP36L1
7 of 15
Yes
Yes
Hsap\ZFP36L2
6 of 15
No
Yes
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Zfp36l1
8 of 15
Yes
Yes
Mmus\Zfp36
7 of 15
No
Yes
Mmus\Zfp36l2
6 of 15
No
Yes
Mmus\Zfp36l3
4 of 15
No
Yes
Rattus norvegicus (Norway rat) (5)
Rnor\Zfp36l2
5 of 13
Yes
Yes
Rnor\LOC100911319
4 of 13
No
Yes
Rnor\Zfp36l3
4 of 13
No
Yes
Rnor\Zfp36
4 of 13
No
Yes
Rnor\Zfp36l1
3 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (6)
Xtro\zfp36l1
7 of 12
Yes
Yes
Xtro\zfp36l2
7 of 12
Yes
Yes
Xtro\zfp36
6 of 12
No
Yes
Xtro\zfp36l2.1
4 of 12
No
Yes
Xtro\zfp36l2.2
4 of 12
No
Yes
Xtro\LOC734009
1 of 12
No
Yes
Danio rerio (Zebrafish) (7)
Drer\zfp36l1a
8 of 15
Yes
Yes
Drer\LOC100334443
7 of 15
No
Yes
Drer\zfp36l1b
7 of 15
No
Yes
Drer\zfp36l2
7 of 15
No
Yes
Drer\zgc:114130
6 of 15
No
Yes
Drer\cth1
5 of 15
No
Yes
Drer\zgc:162730
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (21)
Cele\ccch-1
8 of 15
Yes
Yes
Cele\moe-3
7 of 15
No
Yes
Cele\ccch-2
6 of 15
No
Yes
Cele\ccch-5
6 of 15
No
Yes
Cele\oma-1
6 of 15
No
Yes
Cele\oma-2
6 of 15
No
Yes
Cele\pos-1
6 of 15
No
Yes
Cele\Y60A9.3
6 of 15
No
Yes
Cele\C35D6.4
5 of 15
No
Yes
Cele\dct-13
5 of 15
No
Yes
Cele\F38C2.7
5 of 15
No
Yes
Cele\Y116A8C.19
5 of 15
No
Yes
Cele\Y116A8C.20
5 of 15
No
Yes
Cele\mex-5
4 of 15
No
Yes
Cele\gla-3
3 of 15
No
Yes
Cele\mex-1
3 of 15
No
Yes
Cele\mex-6
3 of 15
No
Yes
Cele\F02E11.4
1 of 15
No
Yes
Cele\pie-1
1 of 15
No
Yes
Cele\Y110A2AL.1
1 of 15
No
Yes
Cele\Y110A2AL.10
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (21)
Atha\AT1G66810
3 of 9
Yes
Yes
Atha\AT1G68200
2 of 9
No
Yes
Atha\HUA1
2 of 9
No
Yes
Atha\AT1G04990
1 of 9
No
Yes
Atha\AT1G32360
1 of 9
No
Yes
Atha\AT2G35430
1 of 9
No
Yes
Atha\AT2G47850
1 of 9
No
Yes
Atha\AT3G06410
1 of 9
No
Yes
Atha\AT3G19360
1 of 9
No
Yes
Atha\AT3G48440
1 of 9
No
Yes
Atha\AT5G18550
1 of 9
No
Yes
Atha\AT5G44260
1 of 9
No
No
Atha\AT5G63260
1 of 9
No
Yes
Atha\ATCTH
1 of 9
No
No
Atha\CZF1
1 of 9
No
No
Atha\OZF2
1 of 9
No
No
Atha\SOM
1 of 9
No
No
Atha\SZF1
1 of 9
No
No
Atha\ZFN1
1 of 9
No
Yes
Atha\ZFN2
1 of 9
No
Yes
Atha\ZFN3
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\TIS11
9 of 15
Yes
Yes
Scer\CTH1
8 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\zfs1
5 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190EV9 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006438
Drosophila simulans
Dsim\GD28720
Drosophila sechellia
Dsec\GM11580
Drosophila erecta
Dere\GG17735
Drosophila yakuba
Dyak\GE17025
Drosophila ananassae
Dana\GF21384
Drosophila pseudoobscura pseudoobscura
Dpse\GA17935
Drosophila persimilis
Dper\GL13141
Drosophila willistoni
Dwil\GK25600
Drosophila virilis
Dvir\GJ15863
Drosophila mojavensis
Dmoj\GI21684
Drosophila grimshawi
Dgri\GH17894
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091508I5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17022050
Musca domestica
House fly
Mdoa\17017568
Glossina morsitans
Tsetse fly
Gmor\GMOY004510
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_01185
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL002308
Anopheles gambiae
Malaria mosquito
Agam\AGAP010954
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018734
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0F9A )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008337
Danaus plexippus
Monarch butterfly
Dple\DPOGS206634-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011155
Apis florea
Little honeybee
Aflo\3196122644
Apis mellifera
Western honey bee
Amel\GB41549
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24820
Bombus terrestris
Buff-tailed bumblebee
Bter\15209992
Linepithema humile
Argentine ant
Lhum\LH15405
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00187e
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG031970
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04626
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00972
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09419
Tribolium castaneum
Red flour beetle
Tcas\TC032794
Cimex lectularius
Bed bug
Clec\CLEC011195
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003590
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18670
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0F8S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009063
Ixodes scapularis
Black-legged tick
Isca\ISCW019074
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74905.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61703.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g02330
Tetranychus urticae
Two-spotted spider mite
Turt\tetur37g00610
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_9312
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0957 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Oma
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023848
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000014446
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Tis11EY09433
    exacerbates  tauopathy
    modeled by Hsap\MAPTGMR.Ex.PJ
    (Ambegaokar and Jackson, 2011)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ZFP36; ZFP36 ring finger protein
    7 of 15
    190700
        ZFP36L1; ZFP36 ring finger protein like 1
        7 of 15
        601064
            ZFP36L2; ZFP36 ring finger protein like 2
            6 of 15
            612053
                 
                Functional Complementation Data
                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                Interactions
                Summary of Physical Interactions
                Summary of Genetic Interactions
                esyN Network Diagram
                esyN Network Key:
                Suppression
                Enhancement
                View in Interactions Browser
                Please look at the allele data for full details of the genetic interactions
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Tis11
                suppressible
                Pop2
                (McClelland et al., 2017)
                Starting gene(s)
                Interaction type
                Interacting gene(s)
                Reference
                Pop2
                suppressible
                Tis11
                (McClelland et al., 2017)
                External Data
                Linkouts
                BioGRID - A database of protein and genetic interactions.
                DroID - A comprehensive database of gene and protein interactions.
                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                MIST (protein-protein) - An integrated Molecular Interaction Database
                Pathways
                Signaling Pathways (FlyBase)
                Metabolic Pathways
                External Data
                Linkouts
                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                Genomic Location and Detailed Mapping Data
                Chromosome (arm)
                X
                Recombination map
                1-39
                Cytogenetic map
                11B9-11B10
                Sequence location
                X:12,659,415..12,682,560 [+]
                FlyBase Computed Cytological Location
                Cytogenetic map
                Evidence for location
                11B9-11B10
                Limits computationally determined from genome sequence between P{EP}CG11138EP1313 and P{EP}EP1632&P{EP}EP1449
                Experimentally Determined Cytological Location
                Cytogenetic map
                Notes
                References
                11C-11C
                (determined by in situ hybridisation)
                (Peter et al., 2002)
                12B-12B
                (Ma, 1994.8.12)
                11B-11C
                (determined by in situ hybridisation)
                (Schäfer et al., 1999.6.15)
                11B-11B
                (determined by in situ hybridisation)
                (Warbrick and Glover, 1994)
                11B14-11B16
                (determined by in situ hybridisation)
                (Ma et al., 1994)
                Experimentally Determined Recombination Data
                Location

                1-39

                (FlyBase, 2016)

                1-39.6

                (Comeron et al., 2012)

                1-

                (Ma, 1994.8.12)
                Left of (cM)
                Right of (cM)
                Notes
                Stocks and Reagents
                Stocks (14)
                Genomic Clones (15)
                 

                Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                cDNA Clones (422)
                 

                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                cDNA clones, fully sequenced
                BDGP DGC clones
                Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Choi et al., 2014, Lauwers et al., 2009)

                  monoclonal

                  (Ngoc et al., 2014, Twyffels et al., 2013)
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for database merge of

                  Source for merge of: Tis11 l(1)G0124

                  (Peter et al., 2002)
                  Additional comments

                  Tis11 complements the temperature-sensitive phenotype of the S.pombe cdr1-34 cdc25-22 double mutant, but does not complement the cell division phenotype of the cdc25-22 single mutant strain and does not affect the length of the cell at division in the cdr1-34 single mutant strain.

                  (Warbrick and Glover, 1994)
                  Other Comments

                  Tis11 has been cloned from a Drosophila eye disc cDNA library.

                  (Ma et al., 1994)

                  Tis11 has been cloned and sequenced.

                  (Warbrick and Glover, 1994)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 50 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  modMine - A data warehouse for the modENCODE project
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (18)
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
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                  References (79)