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Gene Dmel\AcCoAS

General Information
Symbol	Dmel\AcCoAS	Species	D. melanogaster
Name	Acetyl Coenzyme A synthase	Annotation symbol	CG9390
Feature type	protein_coding_gene	FlyBase ID	FBgn0012034
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	ACS, dACS
Genomic Location
Chromosome (arm)	3L	Recombination map	3-
Cytogenetic map	78C3-78C4	Sequence location	3L:21,263,822..21,273,343 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Acetyl Coenzyme A synthase is referred to in FlyBase by the symbol Dmel\AcCoAS (CG9390, FBgn0012034). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: acetate-CoA ligase activity. There is experimental evidence that it is involved in the biological process: behavioral response to ethanol. 13 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: AMP-binding, conserved site; AMP-dependent synthetase/ligase; Acetate-CoA ligase; Acyl-CoA synthase, domain of unknown function DUF3448; Domain of unknown function DUF4009. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval Malpighian tubules, adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1641148_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of AcCoAS. Gene sequence location is 3L:21263822..21273343.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 78C3-78C4   Limits computationally determined from genome sequence between P{EP}chbEP3403 and P{PZ}ppl00217
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\AcCoAS for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) AcCoAS-RA FBtr0078413  NM_168894   3454   670 AcCoAS-RB FBtr0078414  NM_079472   2349   524 AcCoAS-RD FBtr0333126  NM_001014599   2705   670
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein AcCoAS-PA   FBpp0078067   75.9   670   5.44     NP_730611   AAF51695 AcCoAS-PB   FBpp0078068   58.8   524   5.27     NP_524196   AAF51696 AcCoAS-PD   FBpp0305337   75.9   670   5.44     NP_001014599   AAX52767
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • AMP-dependent synthetase/ligase (IPR000873) Acetate-CoA ligase (IPR011904) Domain of unknown function DUF4009 (IPR025110) AMP-binding, conserved site (IPR020845) Acyl-CoA synthase, domain of unknown function DUF3448 (IPR024597)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA392577   AA568078   AA698056   AA942227   AA949718   AA978527   AE014296 AAF51695   AE014296 AAF51696   AE014296 AAX52767   AI062594   AI063198   AI107517   AI108563   AI108690   AI109073   AI110181   AI134157   AI135231   AI238202   AI238448   AI296028   AI296293   AI386920   AI387638   AI387947   AI388482   AI388583   AI389379   AI402321   AI402709   AI403335   AI404580   AI404787   AI406129   AI456719   AI456950   AI512205   AI514059   AI516850   AI517314   AI517451   AI518685   AI533405   AI533965   AI541894   AW942251   AY089540 AAL90278   BG633498   BG633513   BG637670   BI163845   BI169546   BI170819   BI230094   BI231790   BI356830   BI362122   BI366122   BI371032   BI372850   BI373388   BI374733   BI374815   BI374912   BI375997   BI563762   BI565175   BI565354   BI565379   BI567566   BI567697   BI567704   BI567934   BI575097   BI576016   BI576079   BI576441   BI576896   BI581319   BI581403   BI582076   BI582142   BI586102   BI586231   BI587789   BI588063   BI591541   BI604471   BI605578   BI606364   BI606373   BI607801   BI611331   BI612206   BI617626   BI619293   BI620978   BI621635   BI624504   BI624772   BI626920   BI631041   BT001456 AAN71211   BT126330   CA806318   CL610138   CL868583   CO177967   CO182795   CO186713   CO194879   CO269359   CO270077   CO270092   CO271392   CO278969   CO282354   CO286985   CO296002   CO305967   CO313452   CO314934   CO321644   CO325382   CO326554   CO328032   CO330436   CO336881   CO342298   CZ476208   CZ481147   CZ484113   CZ484114   CZ486038   CZ486039   CZ488286   EC058964   EC064311   EC065520   EC068894   EC077447   EC200967   EC204949   EC208600   EC210354   EC214015   EC218053   EC218488   EC230201   EC231774   EC236187   EC237478   EC243176   EC252276   EC252873   EC266923   EL872827   EL872828   ES692133   EV574958   EV581050   EV583700   EV583738   EV584588   EV584653   EV594203   EV594721   EV594883   GH746580   Z46786 CAA86738
UniProtKB/Swiss-Prot	Q9VP61
UniProtKB/TrEMBL	Q59E09
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval Malpighian tubules, adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    285.15 Larval Midgut    1159.3 Larval Hindgut    900.5 Larval Malpighian Tubules    402.4 Larval Fat Body    1867.3 Larval Salivary Gland    73 Larval Trachea    162.65 Larval Carcass    281.8 Adult Head    2067.3 Adult Eye    1000.6 Adult Brain    845.2 Adult Thoracic-Abdominal Ganglion    733.8 Adult Crop    3784 Adult Midgut    1344.6 Adult Hindgut    1713.7 Adult Malpighian Tubules    2702.4 Adult Fat Body    4226.9 Adult Salivary Gland    104.1 Adult Heart    2973.8 Adult VirginFemale Spermatheca    4687 Adult InseminatedFemale Spermatheca    4141.9 Adult Ovary    303.5 Adult Testis    22.9 Adult Male Accessory Gland    167.7 Adult Carcass    3224.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    285.15 Larval Midgut  (1159.3) Larval Hindgut  (900.5) Larval Malpighian Tubules    402.4 Larval Fat Body  (1867.3) Larval Salivary Gland    73 Larval Trachea    162.65 Larval Carcass    281.8 Adult Head  (2067.3) Adult Eye  (1000.6) Adult Brain  (845.2) Adult Thoracic-Abdominal Ganglion  (733.8) Adult Crop  (3784) Adult Midgut  (1344.6) Adult Hindgut  (1713.7) Adult Malpighian Tubules  (2702.4) Adult Fat Body  (4226.9) Adult Salivary Gland    104.1 Adult Heart  (2973.8) Adult VirginFemale Spermatheca  (4687) Adult InseminatedFemale Spermatheca  (4141.9) Adult Ovary    303.5 Adult Testis    22.9 Adult Male Accessory Gland    167.7 Adult Carcass  (3224.5) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    285.15 Larval Midgut  (1159.3) Larval Hindgut    900.5 Larval Malpighian Tubules    402.4 Larval Fat Body  (1867.3) Larval Salivary Gland    73 Larval Trachea    162.65 Larval Carcass    281.8 Adult Head  (2067.3) Adult Eye  1000.6 Adult Brain    845.2 Adult Thoracic-Abdominal Ganglion    733.8 Adult Crop  (3784) Adult Midgut  (1344.6) Adult Hindgut  (1713.7) Adult Malpighian Tubules  (2702.4) Adult Fat Body  (4226.9) Adult Salivary Gland    104.1 Adult Heart  (2973.8) Adult VirginFemale Spermatheca  (4687) Adult InseminatedFemale Spermatheca  (4141.9) Adult Ovary    303.5 Adult Testis    22.9 Adult Male Accessory Gland    167.7 Adult Carcass  (3224.5) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    285.15 Larval Midgut    1159.3 Larval Hindgut    900.5 Larval Malpighian Tubules    402.4 Larval Fat Body    1867.3 Larval Salivary Gland    73 Larval Trachea    162.65 Larval Carcass    281.8 Adult Head    2067.3 Adult Eye    1000.6 Adult Brain    845.2 Adult Thoracic-Abdominal Ganglion    733.8 Adult Crop    3784 Adult Midgut    1344.6 Adult Hindgut    1713.7 Adult Malpighian Tubules    2702.4 Adult Fat Body    4226.9 Adult Salivary Gland    104.1 Adult Heart    2973.8 Adult VirginFemale Spermatheca    4687 Adult InseminatedFemale Spermatheca    4141.9 Adult Ovary    303.5 Adult Testis    22.9 Adult Male Accessory Gland    167.7 Adult Carcass    3224.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    285.15 Larval Midgut    1159.3 Larval Hindgut    900.5 Larval Malpighian Tubules    402.4 Larval Fat Body    1867.3 Larval Salivary Gland    73 Larval Trachea    162.65 Larval Carcass    281.8 Adult Head    2067.3 Adult Eye    1000.6 Adult Brain    845.2 Adult Thoracic-Abdominal Ganglion    733.8 Adult Crop    3784 Adult Midgut    1344.6 Adult Hindgut    1713.7 Adult Malpighian Tubules    2702.4 Adult Fat Body    4226.9 Adult Salivary Gland    104.1 Adult Heart    2973.8 Adult VirginFemale Spermatheca    4687 Adult InseminatedFemale Spermatheca    4141.9 Adult Ovary    303.5 Adult Testis    22.9 Adult Male Accessory Gland    167.7 Adult Carcass    3224.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    285.15 Larval Midgut  (1159.3) Larval Hindgut  (900.5) Larval Malpighian Tubules    402.4 Larval Fat Body  (1867.3) Larval Salivary Gland    73 Larval Trachea    162.65 Larval Carcass    281.8 Adult Head  (2067.3) Adult Eye  (1000.6) Adult Brain  (845.2) Adult Thoracic-Abdominal Ganglion  733.8 Adult Crop  (3784) Adult Midgut  (1344.6) Adult Hindgut  (1713.7) Adult Malpighian Tubules  (2702.4) Adult Fat Body  (4226.9) Adult Salivary Gland    104.1 Adult Heart  (2973.8) Adult VirginFemale Spermatheca  (4687) Adult InseminatedFemale Spermatheca  (4141.9) Adult Ovary    303.5 Adult Testis    22.9 Adult Male Accessory Gland    167.7 Adult Carcass  (3224.5) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    285.15 Larval Midgut  1159.3 Larval Hindgut    900.5 Larval Malpighian Tubules    402.4 Larval Fat Body  (1867.3) Larval Salivary Gland    73 Larval Trachea    162.65 Larval Carcass    281.8 Adult Head  (2067.3) Adult Eye  1000.6 Adult Brain    845.2 Adult Thoracic-Abdominal Ganglion    733.8 Adult Crop  (3784) Adult Midgut  1344.6 Adult Hindgut  1713.7 Adult Malpighian Tubules  (2702.4) Adult Fat Body  (4226.9) Adult Salivary Gland    104.1 Adult Heart  (2973.8) Adult VirginFemale Spermatheca  (4687) Adult InseminatedFemale Spermatheca  (4141.9) Adult Ovary    303.5 Adult Testis    22.9 Adult Male Accessory Gland    167.7 Adult Carcass  (3224.5) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    285.15 Larval Midgut    1159.3 Larval Hindgut    900.5 Larval Malpighian Tubules    402.4 Larval Fat Body    1867.3 Larval Salivary Gland    73 Larval Trachea    162.65 Larval Carcass    281.8 Adult Head    2067.3 Adult Eye    1000.6 Adult Brain    845.2 Adult Thoracic-Abdominal Ganglion    733.8 Adult Crop    3784 Adult Midgut    1344.6 Adult Hindgut    1713.7 Adult Malpighian Tubules    2702.4 Adult Fat Body    4226.9 Adult Salivary Gland    104.1 Adult Heart    2973.8 Adult VirginFemale Spermatheca    4687 Adult InseminatedFemale Spermatheca    4141.9 Adult Ovary    303.5 Adult Testis    22.9 Adult Male Accessory Gland    167.7 Adult Carcass    3224.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2067.3   NA  Eye    1000.6   NA  Brain    845.2   285.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    733.8   NA  Crop    3784   1159.3  Midgut    1344.6   900.5  Hindgut    1713.7   402.4  Malpighian Tubules    2702.4   1867.3  Fat Body    4226.9   73  Salivary Gland    104.1   NA  Heart    2973.8   162.65  Trachea    NA   NA  VirginFemale Spermatheca    4687   NA  InseminatedFemale Spermatheca    4141.9   NA  Ovary    303.5   NA  Testis    22.9   NA  Male Accessory Gland    167.7   281.8  Carcass    3224.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    7 central nervous system, pupae P8    15 head, virgin 1-day female    118 head, virgin 4-day female    145 head, virgin 20-day female    316 head, mated 1-day female    113 head, mated 4-day female    271 head, mated 20-day female    224 head, mated 1-day male    137 head, mated 4-day male    225 head, mated 20-day male    305 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    75 digestive system, 4-day adult    63 digestive system, 20-day adult    78 fat body, larvae L3 wandering    86 fat body, white prepupae    7 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult    105 carcass, 4-day adult    117 carcass, 20-day adult    180 ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male    7 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    7 central nervous system, pupae P8    15 head, virgin 1-day female  (118) head, virgin 4-day female  (145) head, virgin 20-day female  (316) head, mated 1-day female  (113) head, mated 4-day female  (271) head, mated 20-day female  (224) head, mated 1-day male  (137) head, mated 4-day male  (225) head, mated 20-day male  (305) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    11 digestive system, 1-day adult  (75) digestive system, 4-day adult  (63) digestive system, 20-day adult  (78) fat body, larvae L3 wandering  (86) fat body, white prepupae    7 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult  (105) carcass, 4-day adult  (117) carcass, 20-day adult  (180) ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male    7 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    7 central nervous system, pupae P8    15 head, virgin 1-day female  (118) head, virgin 4-day female  (145) head, virgin 20-day female  (316) head, mated 1-day female  (113) head, mated 4-day female  (271) head, mated 20-day female  (224) head, mated 1-day male  (137) head, mated 4-day male  (225) head, mated 20-day male  (305) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    75 digestive system, 4-day adult    63 digestive system, 20-day adult    78 fat body, larvae L3 wandering    86 fat body, white prepupae    7 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult  105 carcass, 4-day adult  (117) carcass, 20-day adult  (180) ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male    7 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    7 central nervous system, pupae P8    15 head, virgin 1-day female    118 head, virgin 4-day female    145 head, virgin 20-day female    316 head, mated 1-day female    113 head, mated 4-day female    271 head, mated 20-day female    224 head, mated 1-day male    137 head, mated 4-day male    225 head, mated 20-day male    305 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    75 digestive system, 4-day adult    63 digestive system, 20-day adult    78 fat body, larvae L3 wandering    86 fat body, white prepupae    7 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult    105 carcass, 4-day adult    117 carcass, 20-day adult    180 ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male    7 accessory gland, mated 4-day male    23 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    7 central nervous system, pupae P8    15 head, virgin 1-day female    118 head, virgin 4-day female    145 head, virgin 20-day female    316 head, mated 1-day female    113 head, mated 4-day female    271 head, mated 20-day female    224 head, mated 1-day male    137 head, mated 4-day male    225 head, mated 20-day male    305 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    75 digestive system, 4-day adult    63 digestive system, 20-day adult    78 fat body, larvae L3 wandering    86 fat body, white prepupae    7 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult    105 carcass, 4-day adult    117 carcass, 20-day adult    180 ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male    7 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    7 central nervous system, pupae P8    15 head, virgin 1-day female  (118) head, virgin 4-day female  (145) head, virgin 20-day female  (316) head, mated 1-day female  (113) head, mated 4-day female  (271) head, mated 20-day female  (224) head, mated 1-day male  (137) head, mated 4-day male  (225) head, mated 20-day male  (305) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    11 digestive system, 1-day adult  (75) digestive system, 4-day adult  (63) digestive system, 20-day adult  (78) fat body, larvae L3 wandering  (86) fat body, white prepupae    7 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult  (105) carcass, 4-day adult  (117) carcass, 20-day adult  (180) ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male    7 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    7 central nervous system, pupae P8    15 head, virgin 1-day female  118 head, virgin 4-day female  (145) head, virgin 20-day female  (316) head, mated 1-day female  113 head, mated 4-day female  (271) head, mated 20-day female  (224) head, mated 1-day male  137 head, mated 4-day male  (225) head, mated 20-day male  (305) salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    75 digestive system, 4-day adult    63 digestive system, 20-day adult    78 fat body, larvae L3 wandering    86 fat body, white prepupae    7 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult  105 carcass, 4-day adult  117 carcass, 20-day adult  (180) ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male    7 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    7 central nervous system, pupae P8    15 head, virgin 1-day female    118 head, virgin 4-day female    145 head, virgin 20-day female    316 head, mated 1-day female    113 head, mated 4-day female    271 head, mated 20-day female    224 head, mated 1-day male    137 head, mated 4-day male    225 head, mated 20-day male    305 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    1 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    75 digestive system, 4-day adult    63 digestive system, 20-day adult    78 fat body, larvae L3 wandering    86 fat body, white prepupae    7 fat body, pupae P8    4 carcass, larvae L3 wandering    10 carcass, 1-day adult    105 carcass, 4-day adult    117 carcass, 20-day adult    180 ovary, virgin 4-day female    22 ovary, mated 4-day female    17 testis, mated 4-day male    7 accessory gland, mated 4-day male    23 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    13 embryo 16-18hr    18 embryo 18-20hr    58 embryo 20-22hr    162 embryo 22-24hr    211 larva L1    110 larva L2    143 larva L3 12hr old    159 larva L3 puffstage 1-2    90 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    18 white prepupae 24hr    13 pupae 2d postWPP    11 pupae 3d postWPP    18 pupae 4d postWPP    42 adult male 01day    125 adult male 05day    124 adult male 30day    129 adult female 01day    85 adult female 05day    98 adult female 30day    108 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (36) embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    13 embryo 16-18hr    18 embryo 18-20hr  (58) embryo 20-22hr  (162) embryo 22-24hr  (211) larva L1  (110) larva L2  (143) larva L3 12hr old  (159) larva L3 puffstage 1-2  (90) larva L3 puffstage 3-6  (44) larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    18 white prepupae 24hr    13 pupae 2d postWPP    11 pupae 3d postWPP    18 pupae 4d postWPP  (42) adult male 01day  (125) adult male 05day  (124) adult male 30day  (129) adult female 01day  (85) adult female 05day  (98) adult female 30day  (108) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    13 embryo 16-18hr    18 embryo 18-20hr    58 embryo 20-22hr  (162) embryo 22-24hr  (211) larva L1  (110) larva L2  (143) larva L3 12hr old  (159) larva L3 puffstage 1-2    90 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    18 white prepupae 24hr    13 pupae 2d postWPP    11 pupae 3d postWPP    18 pupae 4d postWPP    42 adult male 01day  (125) adult male 05day  (124) adult male 30day  (129) adult female 01day    85 adult female 05day    98 adult female 30day  (108) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    13 embryo 16-18hr    18 embryo 18-20hr    58 embryo 20-22hr    162 embryo 22-24hr    211 larva L1    110 larva L2    143 larva L3 12hr old    159 larva L3 puffstage 1-2    90 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    18 white prepupae 24hr    13 pupae 2d postWPP    11 pupae 3d postWPP    18 pupae 4d postWPP    42 adult male 01day    125 adult male 05day    124 adult male 30day    129 adult female 01day    85 adult female 05day    98 adult female 30day    108 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    13 embryo 16-18hr    18 embryo 18-20hr    58 embryo 20-22hr    162 embryo 22-24hr    211 larva L1    110 larva L2    143 larva L3 12hr old    159 larva L3 puffstage 1-2    90 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    18 white prepupae 24hr    13 pupae 2d postWPP    11 pupae 3d postWPP    18 pupae 4d postWPP    42 adult male 01day    125 adult male 05day    124 adult male 30day    129 adult female 01day    85 adult female 05day    98 adult female 30day    108 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (36) embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    13 embryo 16-18hr    18 embryo 18-20hr  (58) embryo 20-22hr  (162) embryo 22-24hr  (211) larva L1  (110) larva L2  (143) larva L3 12hr old  (159) larva L3 puffstage 1-2  (90) larva L3 puffstage 3-6  (44) larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    18 white prepupae 24hr    13 pupae 2d postWPP    11 pupae 3d postWPP    18 pupae 4d postWPP  (42) adult male 01day  (125) adult male 05day  (124) adult male 30day  (129) adult female 01day  (85) adult female 05day  (98) adult female 30day  (108) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    13 embryo 16-18hr    18 embryo 18-20hr    58 embryo 20-22hr  (162) embryo 22-24hr  (211) larva L1  110 larva L2  143 larva L3 12hr old  (159) larva L3 puffstage 1-2    90 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    18 white prepupae 24hr    13 pupae 2d postWPP    11 pupae 3d postWPP    18 pupae 4d postWPP    42 adult male 01day  125 adult male 05day  124 adult male 30day  129 adult female 01day    85 adult female 05day    98 adult female 30day  108 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    7 embryo 04-06hr    5 embryo 06-08hr    5 embryo 08-10hr    6 embryo 10-12hr    13 embryo 12-14hr    11 embryo 14-16hr    13 embryo 16-18hr    18 embryo 18-20hr    58 embryo 20-22hr    162 embryo 22-24hr    211 larva L1    110 larva L2    143 larva L3 12hr old    159 larva L3 puffstage 1-2    90 larva L3 puffstage 3-6    44 larva L3 puffstage 7-9    20 white prepupae new    22 white prepupae 12hr    18 white prepupae 24hr    13 pupae 2d postWPP    11 pupae 3d postWPP    18 pupae 4d postWPP    42 adult male 01day    125 adult male 05day    124 adult male 30day    129 adult female 01day    85 adult female 05day    98 adult female 30day    108 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    107 embryonic 1182-4H    48 embryonic GM2    86 embryonic Kc167    33 embryonic S1    26 embryonic S3    9 leg disc CME L1    62 wing disc CME-W2    43 wing disc ML-DmD8    33 wing disc ML-DmD9    36 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    51 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    54 eye-antennal disc ML-DmD11    31 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    50 CNS ML-DmBG1-c1    52 CNS ML-DmBG2-c2    64 tumorous blood cells mbn2    26 ovary fGS/OSS    46 ovary OSC    30 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (28) Schneider line 2 Sg4  (107) embryonic 1182-4H  (48) embryonic GM2  (86) embryonic Kc167  (33) embryonic S1  26 embryonic S3    9 leg disc CME L1  (62) wing disc CME-W2  (43) wing disc ML-DmD8  (33) wing disc ML-DmD9  (36) wing disc ML-DmD16-c3  (37) wing disc ML-DmD21  (51) wing disc ML-DmD32    16 haltere disc ML-DmD17-c3  (54) eye-antennal disc ML-DmD11  (31) antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1  (50) CNS ML-DmBG1-c1  (52) CNS ML-DmBG2-c2  (64) tumorous blood cells mbn2  26 ovary fGS/OSS  (46) ovary OSC  (30) ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4  107 embryonic 1182-4H    48 embryonic GM2    86 embryonic Kc167    33 embryonic S1    26 embryonic S3    9 leg disc CME L1    62 wing disc CME-W2    43 wing disc ML-DmD8    33 wing disc ML-DmD9    36 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    51 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    54 eye-antennal disc ML-DmD11    31 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    50 CNS ML-DmBG1-c1    52 CNS ML-DmBG2-c2    64 tumorous blood cells mbn2    26 ovary fGS/OSS    46 ovary OSC    30 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    107 embryonic 1182-4H    48 embryonic GM2    86 embryonic Kc167    33 embryonic S1    26 embryonic S3    9 leg disc CME L1    62 wing disc CME-W2    43 wing disc ML-DmD8    33 wing disc ML-DmD9    36 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    51 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    54 eye-antennal disc ML-DmD11    31 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    50 CNS ML-DmBG1-c1    52 CNS ML-DmBG2-c2    64 tumorous blood cells mbn2    26 ovary fGS/OSS    46 ovary OSC    30 ovary OSS    22 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    107 embryonic 1182-4H    48 embryonic GM2    86 embryonic Kc167    33 embryonic S1    26 embryonic S3    9 leg disc CME L1    62 wing disc CME-W2    43 wing disc ML-DmD8    33 wing disc ML-DmD9    36 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    51 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    54 eye-antennal disc ML-DmD11    31 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    50 CNS ML-DmBG1-c1    52 CNS ML-DmBG2-c2    64 tumorous blood cells mbn2    26 ovary fGS/OSS    46 ovary OSC    30 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  28 Schneider line 2 Sg4  (107) embryonic 1182-4H  (48) embryonic GM2  (86) embryonic Kc167  (33) embryonic S1  26 embryonic S3    9 leg disc CME L1  (62) wing disc CME-W2  (43) wing disc ML-DmD8  (33) wing disc ML-DmD9  (36) wing disc ML-DmD16-c3  (37) wing disc ML-DmD21  (51) wing disc ML-DmD32    16 haltere disc ML-DmD17-c3  (54) eye-antennal disc ML-DmD11  31 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1  (50) CNS ML-DmBG1-c1  (52) CNS ML-DmBG2-c2  (64) tumorous blood cells mbn2  26 ovary fGS/OSS  (46) ovary OSC  30 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4  107 embryonic 1182-4H    48 embryonic GM2    86 embryonic Kc167    33 embryonic S1    26 embryonic S3    9 leg disc CME L1    62 wing disc CME-W2    43 wing disc ML-DmD8    33 wing disc ML-DmD9    36 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    51 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    54 eye-antennal disc ML-DmD11    31 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    50 CNS ML-DmBG1-c1    52 CNS ML-DmBG2-c2    64 tumorous blood cells mbn2    26 ovary fGS/OSS    46 ovary OSC    30 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    107 embryonic 1182-4H    48 embryonic GM2    86 embryonic Kc167    33 embryonic S1    26 embryonic S3    9 leg disc CME L1    62 wing disc CME-W2    43 wing disc ML-DmD8    33 wing disc ML-DmD9    36 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    51 wing disc ML-DmD32    16 haltere disc ML-DmD17-c3    54 eye-antennal disc ML-DmD11    31 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    50 CNS ML-DmBG1-c1    52 CNS ML-DmBG2-c2    64 tumorous blood cells mbn2    26 ovary fGS/OSS    46 ovary OSC    30 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    49 Cadmium 50 mM 6 hrs, larvae L3    89 Cadmium 50 mM 12 hrs, larvae L3    39 Cadmium 50 mM 48 hrs, 4-day adult    48 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    160 Ethanol 10% 3 hrs, larvae L3    88 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    57 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult  (49) Cadmium 50 mM 6 hrs, larvae L3  (89) Cadmium 50 mM 12 hrs, larvae L3  (39) Cadmium 50 mM 48 hrs, 4-day adult  (48) Cadmium 100 mM 48 hrs, 4-day adult  (31) Copper 0.5 mM 12 hrs, larvae L3  (36) Copper 15 mM 48 hrs, 4-day adult  (31) Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult  (38) Ethanol 2.5% 3 hrs, larvae L3  (49) Ethanol 5% 3 hrs, larvae L3  (160) Ethanol 10% 3 hrs, larvae L3  (88) Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (57) Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult  (45) Paraquat 10 mM 48 hrs, 4-day adult  (57) Rotenone 2 μg 12 hrs, larvae L3  (34) Rotenone 8 μg 12 hrs, larvae L3  (55) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    49 Cadmium 50 mM 6 hrs, larvae L3    89 Cadmium 50 mM 12 hrs, larvae L3    39 Cadmium 50 mM 48 hrs, 4-day adult    48 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3  (160) Ethanol 10% 3 hrs, larvae L3    88 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    57 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    49 Cadmium 50 mM 6 hrs, larvae L3    89 Cadmium 50 mM 12 hrs, larvae L3    39 Cadmium 50 mM 48 hrs, 4-day adult    48 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    160 Ethanol 10% 3 hrs, larvae L3    88 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    57 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    55 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    49 Cadmium 50 mM 6 hrs, larvae L3    89 Cadmium 50 mM 12 hrs, larvae L3    39 Cadmium 50 mM 48 hrs, 4-day adult    48 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    160 Ethanol 10% 3 hrs, larvae L3    88 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    57 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult  (49) Cadmium 50 mM 6 hrs, larvae L3  (89) Cadmium 50 mM 12 hrs, larvae L3  (39) Cadmium 50 mM 48 hrs, 4-day adult  (48) Cadmium 100 mM 48 hrs, 4-day adult  31 Copper 0.5 mM 12 hrs, larvae L3  (36) Copper 15 mM 48 hrs, 4-day adult  31 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult  (38) Ethanol 2.5% 3 hrs, larvae L3  (49) Ethanol 5% 3 hrs, larvae L3  (160) Ethanol 10% 3 hrs, larvae L3  (88) Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (57) Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult  (45) Paraquat 10 mM 48 hrs, 4-day adult  (57) Rotenone 2 μg 12 hrs, larvae L3  (34) Rotenone 8 μg 12 hrs, larvae L3  (55) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    49 Cadmium 50 mM 6 hrs, larvae L3    89 Cadmium 50 mM 12 hrs, larvae L3    39 Cadmium 50 mM 48 hrs, 4-day adult    48 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3  (160) Ethanol 10% 3 hrs, larvae L3    88 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    57 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    49 Cadmium 50 mM 6 hrs, larvae L3    89 Cadmium 50 mM 12 hrs, larvae L3    39 Cadmium 50 mM 48 hrs, 4-day adult    48 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    36 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    22 Zinc 4.5 mM 48 hrs, 4-day adult    38 Ethanol 2.5% 3 hrs, larvae L3    49 Ethanol 5% 3 hrs, larvae L3    160 Ethanol 10% 3 hrs, larvae L3    88 Caffeine 1.5 mg/ml 4 hrs, larvae L3    22 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    57 Caffeine 25 mg/ml 48 hrs, 4-day adult    18 Paraquat 5 mM 48 hrs, 4-day adult    45 Paraquat 10 mM 48 hrs, 4-day adult    57 Rotenone 2 μg 12 hrs, larvae L3    34 Rotenone 8 μg 12 hrs, larvae L3    55 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_10 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0012034 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9390-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable AcCoASEY12601 AcCoASf03474 Sterility Allele fertile AcCoASEY12601 AcCoASf03474 Other Phenotypes Allele chemical sensitive AcCoASf03474 hypoactive | conditional AcCoASf03474 smell perception defective | conditional AcCoASf03474 Phenotype manifest in Allele
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of AcCoAS Class Mutagen Stocks Known lesion AcCoAS00217 P-element activity 1 -- AcCoASCB-6224-3 1 -- AcCoASd08389 P-element activity 1 -- AcCoASe03377 piggyBac transposase 1 -- AcCoASEY03478 P-element activity 1 -- AcCoASEY12601 P-element activity 1 -- AcCoASf01646 piggyBac transposase 1 -- AcCoASf03474 hypomorphic allele - molecular evidence piggyBac transposase 1 -- AcCoASUM-8000-3 1 -- AcCoASf05672 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of AcCoAS Class Mutagen Stocks Known lesion AcCoASHMS02314 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AcCoASKK107433 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AcCoASGD5151 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)ppl06913 (Zinke et al., 1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5151} NA P{KK107433} NA P{TRiP.HMS02314} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}ppl00217 No insertion of mobile activating element P{EPgy2}AcCoASEY03478 NA P{EPgy2}AcCoASEY12601 NA P{XP}AcCoASd08389 NA miscellaneous insertions P{RS3}AcCoASCB-6224-3 NA P{RS3}AcCoASUM-8000-3 NA PBac{RB}AcCoASe03377 NA PBac{WH}AcCoASf01646 NA PBac{WH}AcCoASf03474 NA PBac{WH}AcCoASf05672 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
behavioral response to ethanol inferred from mutant phenotype (Kong et al., 2010)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
acetate-CoA ligase activity inferred from sequence or structural similarity with Saccharomyces ACS2 (FlyBase, 1992-) non-traceable author statement (assigned by UniProtKB) (Russell, 1994.11.22) AMP binding inferred from electronic annotation with InterPro:IPR011904 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
acetyl-CoA biosynthetic process from acetate inferred from electronic annotation with InterPro:IPR011904 (FlyBase Curators et al., 2004-) metabolic process non-traceable author statement (assigned by UniProtKB) (Russell, 1994.11.22)
Cellular Component
CV term Evidence References
cytoplasm non-traceable author statement (assigned by UniProtKB) (Russell, 1994.11.22)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions AcCoAS allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65596 DroID - A comprehensive database of gene and protein interactions. • FBgn0012034 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40348
Orthologs
OrthoDB Orthologs (53) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6RNBTW Dipteran inclusive ortholog search EOG6MGSGJ Insect inclusive ortholog search EOG61RNQ0 Arthropod inclusive ortholog search EOG64QRG0 Metazoa inclusive ortholog search EOG6M3P2G
Orthologs in Drosophila Species (EOG6RNBTW)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\AcCoAS     Drosophila simulans   Dsim\GD12130 Y   Drosophila sechellia   Dsec\GM22154 Y   Drosophila erecta   Dere\GG13250 Y   Drosophila yakuba   Dyak\GE22961     Drosophila ananassae   Dana\GF10175 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21752 Y   Drosophila persimilis   Dper\GL24594 Y   Drosophila willistoni   Dwil\GK20397 Y   Drosophila virilis   Dvir\GJ11432 Y   Drosophila mojavensis   Dmoj\GI12200 Y   Drosophila grimshawi   Dgri\GH23686     Drosophila grimshawi   Dgri\GH16518 Y
Orthologs in non-Drosophila Dipterans (EOG6MGSGJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015010   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000321   Anopheles gambiae Malaria mosquito  Agam\AGAP006569   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016639
Orthologs in non-Dipteran Insects (EOG61RNQ0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46290   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG019884   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17349   Atta cephalotes Leafcutter ant  Acep\ACEP15069   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20335   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20755   Linepithema humile Argentine ant  Lhum\LH11870   Pogonomyrmex barbatus Red harvester ant  Pbar\PB17255   Solenopsis invicta Red fire ant  Sinv\SINV20498   Solenopsis invicta Red fire ant  Sinv\SINV20499   Acyrthosiphon pisum Pea aphid  Apim\ACYPI069332   Acyrthosiphon pisum Pea aphid  Apim\ACYPI085620   Bombyx mori Silkmoth  Bmor\BGIBMGA000721   Tribolium castaneum Red flour beetle  Tcas\TC010479
Orthologs in non-Insect Arthropods (EOG64QRG0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_187743   Daphnia pulex Water flea  Dpux\Clic3   Ixodes scapularis Deer tick  Isca\ISCW016681   Ixodes scapularis Deer tick  Isca\ISCW016835
Orthologs in non-Arthropod Metazoa (EOG6M3P2G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\acs-19   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018270gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015048gn   Danio rerio Zebrafish  Drer\acss2   Danio rerio Zebrafish  Drer\acss1   Danio rerio Zebrafish  Drer\ENSDARG00000069029   Xenopus tropicalis Western clawed frog  Xtro\acss1   Xenopus tropicalis Western clawed frog  Xtro\acss2.1   Xenopus tropicalis Western clawed frog  Xtro\acss2.2   Gallus gallus Domestic chicken  Ggal\ACSS2   Gallus gallus Domestic chicken  Ggal\ACSS1   Gallus gallus Domestic chicken  Ggal\LOC423347   Mus musculus House mouse  Mmus\Acss2   Mus musculus House mouse  Mmus\Acss1   Rattus norvegicus Norway rat  Rnor\Acss2   Rattus norvegicus Norway rat  Rnor\Acss1   Homo sapiens Human  Hsap\ACSS2   Homo sapiens Human  Hsap\ACSS1
Human Orthologs (2)
Gene OMIM HGNC Hsap\ACSS2     Hsap\ACSS1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD12130 Drosophila sechellia Dsec\GM22154 Drosophila erecta Dere\GG13250 Drosophila yakuba Dyak\GE22350 Drosophila ananassae Dana\GF10175 Drosophila pseudoobscura pseudoobscura Dpse\GA21752 Drosophila persimilis Dper\GL24594 Drosophila willistoni Dwil\GK20397 Drosophila virilis Dvir\GJ11432 Drosophila mojavensis Dmoj\GI12200 Drosophila grimshawi Dgri\GH16518
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	20761 y1 w67c23; P{EPgy2}AcCoASEY12601 41917 y1 sc* v1; P{TRiP.HMS02314}attP2 19997 y1 w67c23; P{EPgy2}AcCoASEY03478/TM3, Sb1 Ser1 11490 w1118; P{PZ}ppl00217 AcCoAS00217 ry506/TM3, Sb1 Ser1
Harvard	- P{XP}AcCoASd08389 - PBac{RB}AcCoASe03377 - PBac{WH}AcCoASf01646 - PBac{WH}AcCoASf03474
Kyoto	123983 w1118; P{RS3}AcCoASCB-6224-3 124270 w1118; P{RS3}AcCoASUM-8000-3
VDRC	v100281 P{KK107433}VIE-260B
Genomic Clones ( 1 )
	BACR02C22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 150 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM15363 LD12826
Other clones	FI04028
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01843 GH02731 GH05240 GH07585 GH07750 GH07911 GH09693 GH11534 GH12894 GH14213 GH14491 GH17308 GH18212 GH18653 GH19418 GH19540 GH20533 GH21368 GH21985 GH22752 GH24344 GH24620 GH26334 GH27113 GH27431 GH28022 GH28817 HL01257 LD26319 LD29708 LD30771 LD36835 LD37128 LD38347 LD43968 LP09820 LP10150 RE03361 RE10754 RE12411 RE24331 RE43065 RE46602 RE51578 RE57836 RE60036 RE60658 RE62405 RE62504 RE62605 RE63916 RH06258 RH11743 RH17528 RH18692 RH18790 RH19970 RH20077 RH25857 RH26086 RH27963 RH28663 RH29075 RH32476 RH32578 RH33005 RH33553 RH34465 RH37990 RH38252 RH38259 RH39247 RH40618 RH48020 RH50303 RH52248 RH53011 RH60444 RH62870 RH63114 RH63143 RH64070 RH64432 RH68050 RH69836 RH71405 RH72730 RH72759 SD05204 SD06338 SD07851
Other clones	34710 69301 80067 81161 107284 118875 119012 147291 192345 214413.45 214565.49 561938 CK01.25A.F8 CK01.44A.D9 CK01.64A.A4 CK01.68B.C12 CK01.97C.D6 CK01.123D.E3 CK01.127A.D6 CK01.127A.E7 Dmel_dig_009114_0672_2033 Dmel_dig_010645_0617_1432 Dmel_dig_012445_0663_1084 Dmel_dig_012910_0629_3419 Dmel_dig_014688_0611_1668 Dmel_dig_020219_0584_3249 Dmel_neb_001221_0694_0384 Dmel_neb_010999_0634_0764 Dmel_neb_014729_0661_2514 EC24035 EC39415 EK022356 EK054842 EK064526 EK094218 EK097320 EK097347 EK103309 EK132503 EK160305 EK186104 EK196355 EK212464 EK232954 EK238439 EK249917 EK295256 EN13422 EP04150 EP08445 EP14427 ESG012d.E21_B11 GH28401 HL03691 IP04680 RP001016086
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0012034 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40348
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: AcCoAS BEST:GH28401 (Rana, 2004.7.8)
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079472 NM_168894 NM_001014599 RefSeq (Proteins) • NP_524196 NP_730611 NP_001014599 DDBJ / EMBL / GenBank • AA392577 AAF51695 AAF51695.2 AAF51696 AAF51696.3 AAL90278 AAN71211 AAX52767 AI517451 AW942251 AY089540 BG633498 BI230094 BT001456 CAA86738 CL610138 CL868583 CZ476208 CZ481147 CZ484113 CZ484114 CZ486038 CZ486039 CZ488286 Z46786 Entrez Gene - A searchable database of RefSeq genes. • 40348 UniProtKB/Swiss-Prot • Q9VP61 UniProtKB/TrEMBL • Q59E09
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • AMP-dependent synthetase/ligase (IPR000873) Acetate-CoA ligase (IPR011904) Domain of unknown function DUF4009 (IPR025110) AMP-binding, conserved site (IPR020845) Acyl-CoA synthase, domain of unknown function DUF3448 (IPR024597)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65596 DroID - A comprehensive database of gene and protein interactions. • FBgn0012034 DRSC - Results from RNAi screens. • FBgn0012034 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0012034 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9390-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0012034 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40348 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40348 modMine - Data generated by the modENCODE project. • FBgn0012034
Synonyms & Secondary IDs ( 19 )
Reported As
Symbol Synonym	AcCoAS (Mendjan et al., 2006, Okamura et al., 2007, O'Keefe et al., 2011, Montooth et al., 2006, Wittkopp et al., 2008, Spresser et al., 2008, Kong et al., 2010, Yampolsky et al., 2012) AcCoAs (Palanker et al., 2009) ACS (Capy et al., 2002, Matthews et al., 2006, Bauer et al., 2009, Matthews et al., 2009, Kunte et al., 2006, Matthews et al., 2010, Karan et al., 2003) BEST:GH28401   CG9390 (Landry et al., 2005, Oba et al., 2004, Seegmiller et al., 2002, Whitfield, 2000.5.8, O'Keefe et al., 2011, Keleman et al., 2009.8.5, Fujikawa et al., 2009, Wittkopp et al., 2008, Haussmann et al., 2008, Inouye, 2010, Oba et al., 2005, Ni et al., 2010.12.1) dACS (Lee et al., 2010, Zhao et al., 2012)
Name Synonym	Ac CoA synthase (Kunte et al., 2006) acetate-coenzyme A ligase (Ashburner, 1998) Acetyl-CoA synthase (Dobrosotskaya et al., 2002, Kong et al., 2010) Acetyl CoA synthase (Seegmiller et al., 2002) acetyl CoA synthase (Zou et al., 2000) AcetylCoA synthase (O'Keefe et al., 2011) Acetyl CoA synthetase (Rawson, 2003) acetyl-CoA synthetase (Russell, 1994.11.22, Bauer et al., 2009, Okamura et al., 2007, Montooth et al., 2006, Karan et al., 2003) acetyl CoA synthetase (Lee et al., 2010) Acetyl-CoA sythase (Teleman et al., 2005) Acetyl Coenzyme A synthase   acetyl-coenzyme A synthase (Matthews et al., 2009) acetyl coenzyme A synthase (Matthews et al., 2010)
Secondary FlyBase IDs
	FBgn0043802
References ( 58 )
Generate a list of	All references relating to this gene ( 58 )
List References by type	Research paper  ( 28 ) Supplementary material  ( 6 ) Review  ( 3 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 6 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 4 )
	Defays and Bertoli, 2012, Alcohol 46(8): 737--745 Quantitative trait loci for response to ethanol in an intercontinental set of recombinant inbred lines of Drosophila melanogaster. [FBrf0220080] Yampolsky et al., 2012, Mol. Ecol. 21(17): 4287--4299 Evolution of gene expression and expression plasticity in long-term experimental populations of Drosophila melanogaster maintained under constant and variable ethanol stress. [FBrf0219282] Zhao et al., 2012, J. Clin. Invest. 122(7): 2417--2427 Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. [FBrf0218723] O'Keefe et al., 2011, Hum. Mol. Genet. 20(3): 497--509 Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. [FBrf0212691] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...