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Gene Dmel\Aldh

General Information
Symbol	Dmel\Aldh	Species	D. melanogaster
Name	Aldehyde dehydrogenase	Annotation symbol	CG3752
Feature type	protein_coding_gene	FlyBase ID	FBgn0012036
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	30B1-30B1	Sequence location	2L:9,387,389..9,391,567 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Aldehyde dehydrogenase is referred to in FlyBase by the symbol Dmel\Aldh (CG3752, FBgn0012036). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: aldehyde dehydrogenase (NAD) activity; acetaldehyde dehydrogenase (acetylating) activity. There is experimental evidence that it is involved in the biological process: response to ethanol; acetaldehyde metabolic process. 12 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Aldehyde dehydrogenase domain; Aldehyde dehydrogenase, C-terminal; Aldehyde dehydrogenase, N-terminal; Aldehyde dehydrogenase, conserved site; Aldehyde/histidinol dehydrogenase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634096_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Aldh. Gene sequence location is 2L:9387389..9391567.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 30B1-30B1   Limits computationally determined from genome sequence between P{PZ}tai01351 and P{PZ}scat1&P{PZ}numb03235
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Aldh for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Aldh-RA FBtr0079806  NM_135441   2070   520 Aldh-RB FBtr0332597  NM_001273361   1900   520
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Aldh-PA   FBpp0079406   57.0   520   6.79     NP_609285   AAF52769 Aldh-PB   FBpp0304847   57.0   520   6.79     NP_001260290   AGB92825
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Aldehyde dehydrogenase domain (IPR015590) Aldehyde dehydrogenase, conserved site (IPR016160) Aldehyde/histidinol dehydrogenase (IPR016161) Aldehyde dehydrogenase, N-terminal (IPR016162) Aldehyde dehydrogenase, C-terminal (IPR016163) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME03752
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567509   AA568034   AA695136   AA695709   AA697428   AA697523   AA697535   AA698131   AA698285   AA698329   AA699039   AA735760   AA801517   AA803239   AA803483   AA817095   AA940828   AE014134 AAF52769   AE014134 AGB92825   AI062131   AI063150   AI063214   AI063678   AI063684   AI063946   AI064117   AI064340   AI064652   AI106654   AI107818   AI107903   AI108326   AI108493   AI110029   AI110112   AI113504   AI113917   AI114177   AI114267   AI134491   AI134732   AI134794   AI135081   AI135324   AI135448   AI257793   AI259630   AI259946   AI260967   AI292678   AI292842   AI292941   AI293608   AI295861   AI297162   AI297324   AI297670   AI386638   AI387239   AI387315   AI387809   AI387946   AI388493   AI388797   AI389052   AI389261   AI389968   AI402387   AI403095   AI403223   AI403361   AI404224   AI404287   AI404471   AI404592   AI405487   AI517011   AI517013   AI517447   AI517661   AI517715   AI518954   AI531474   AI534357   AI534609   AI543799   AI944470   AI944723   AI945197   AI945440   AI946136   AI946857   BE977337   BE978885   BE979102   BF486340   BF486571   BF487569   BF488219   BF489702   BF492293   BF494040   BF503462   BF505724   BG634067   BG636437   BG640904   BH214611   BI161689   BI161690   BI162984   BI165938   BI170928   BI212294   BI213899   BI213943   BI214016   BI214736   BI214871   BI216666   BI227812   BI228353   BI229317   BI230570   BI234573   BI234785   BI235464   BI239005   BI239414   BI243177   BI243554   BI351683   BI352224   BI354921   BI355643   BI357227   BI358404   BI358544   BI361461   BI362016   BI362368   BI363885   BI365444   BI369631   BI374226   BI374740   BI483844   BI484806   BI485516   BI567095   BI567314   BI567358   BI567435   BI567494   BI570750   BI570754   BI571303   BI571322   BI572367   BI575287   BI576158   BI576790   BI578646   BI580238   BI580393   BI582175   BI582276   BI585282   BI586156   BI588386   BI588746   BI589209   BI589984   BI590281   BI592990   BI593342   BI605206   BI605793   BI606838   BI607128   BI611016   BI613610   BI614799   BI615695   BI616176   BI616569   BI617940   BI618299   BI621305   BI622546   BI623925   BI625015   BI625532   BI627582   BI630419   BI631458   BI632589   BI634202   BI638817   BI641150   BT023716   BT125918   CK086524   CK657155   CK661006   CO195758   CO270928   CO271435   CO271610   CO275361   CO275857   CO285217   CO301136   CO301899   CO301943   CO320471   CO336179   CO337346   CZ471415   EC062744   EC062797   EC085541   EC197412   EC197542   EC197610   EC199860   EC211387   EC216233   EC223945   EC231957   EC238453   EC243485   EC250537   EC262304   EC262426   EL880227   EL880228   ES690210   ES690231   ES690244   ES690252   ES690268   ES690273   ES690298   EV586239   EV592261   EV595354   EV596582   EV600350   GH748653
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VLC5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1   organism   (Fisher et al., 2012) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   anterior endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi head mesoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi posterior ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) procrystal cell   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic midgut chamber   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	Acetaldeyhde dehyrogenase activity from the Aldh gene is mainly cytosolic in adults though some is located in the mitochondria. (Leal and Barbancho, 1993)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Leal and Barbancho, 1993) lipid particle inferred from direct assay (Beller et al., 2006, Cermelli et al., 2006) mitochondrion inferred from direct assay (Leal and Barbancho, 1993, Alonso et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    740.925 Larval Midgut    2034.6 Larval Hindgut    892.6 Larval Malpighian Tubules    735.9 Larval Fat Body    835.3 Larval Salivary Gland    1432.3 Larval Trachea    1151.925 Larval Carcass    612.675 Adult Head    2787 Adult Eye    1477.25 Adult Brain    726.2 Adult Thoracic-Abdominal Ganglion    905 Adult Crop    2778.2 Adult Midgut    1393 Adult Hindgut    1344.4 Adult Malpighian Tubules    2323.2 Adult Fat Body    3704.6 Adult Salivary Gland    2127.2 Adult Heart    2645.1 Adult VirginFemale Spermatheca    3996.7 Adult InseminatedFemale Spermatheca    3829.2 Adult Ovary    920.3 Adult Testis    1464.8 Adult Male Accessory Gland    858.6 Adult Carcass    3133.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (740.925) Larval Midgut  (2034.6) Larval Hindgut  (892.6) Larval Malpighian Tubules  (735.9) Larval Fat Body  (835.3) Larval Salivary Gland  (1432.3) Larval Trachea  (1151.925) Larval Carcass  (612.675) Adult Head  (2787) Adult Eye  (1477.25) Adult Brain  (726.2) Adult Thoracic-Abdominal Ganglion  (905) Adult Crop  (2778.2) Adult Midgut  (1393) Adult Hindgut  (1344.4) Adult Malpighian Tubules  (2323.2) Adult Fat Body  (3704.6) Adult Salivary Gland  (2127.2) Adult Heart  (2645.1) Adult VirginFemale Spermatheca  (3996.7) Adult InseminatedFemale Spermatheca  (3829.2) Adult Ovary  (920.3) Adult Testis  (1464.8) Adult Male Accessory Gland  (858.6) Adult Carcass  (3133.2) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    740.925 Larval Midgut  (2034.6) Larval Hindgut    892.6 Larval Malpighian Tubules    735.9 Larval Fat Body    835.3 Larval Salivary Gland  (1432.3) Larval Trachea  (1151.925) Larval Carcass    612.675 Adult Head  (2787) Adult Eye  (1477.25) Adult Brain    726.2 Adult Thoracic-Abdominal Ganglion    905 Adult Crop  (2778.2) Adult Midgut  (1393) Adult Hindgut  (1344.4) Adult Malpighian Tubules  (2323.2) Adult Fat Body  (3704.6) Adult Salivary Gland  (2127.2) Adult Heart  (2645.1) Adult VirginFemale Spermatheca  (3996.7) Adult InseminatedFemale Spermatheca  (3829.2) Adult Ovary    920.3 Adult Testis  (1464.8) Adult Male Accessory Gland    858.6 Adult Carcass  (3133.2) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    740.925 Larval Midgut    2034.6 Larval Hindgut    892.6 Larval Malpighian Tubules    735.9 Larval Fat Body    835.3 Larval Salivary Gland    1432.3 Larval Trachea    1151.925 Larval Carcass    612.675 Adult Head    2787 Adult Eye    1477.25 Adult Brain    726.2 Adult Thoracic-Abdominal Ganglion    905 Adult Crop    2778.2 Adult Midgut    1393 Adult Hindgut    1344.4 Adult Malpighian Tubules    2323.2 Adult Fat Body    3704.6 Adult Salivary Gland    2127.2 Adult Heart    2645.1 Adult VirginFemale Spermatheca    3996.7 Adult InseminatedFemale Spermatheca    3829.2 Adult Ovary    920.3 Adult Testis    1464.8 Adult Male Accessory Gland    858.6 Adult Carcass    3133.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    740.925 Larval Midgut    2034.6 Larval Hindgut    892.6 Larval Malpighian Tubules    735.9 Larval Fat Body    835.3 Larval Salivary Gland    1432.3 Larval Trachea    1151.925 Larval Carcass    612.675 Adult Head    2787 Adult Eye    1477.25 Adult Brain    726.2 Adult Thoracic-Abdominal Ganglion    905 Adult Crop    2778.2 Adult Midgut    1393 Adult Hindgut    1344.4 Adult Malpighian Tubules    2323.2 Adult Fat Body    3704.6 Adult Salivary Gland    2127.2 Adult Heart    2645.1 Adult VirginFemale Spermatheca    3996.7 Adult InseminatedFemale Spermatheca    3829.2 Adult Ovary    920.3 Adult Testis    1464.8 Adult Male Accessory Gland    858.6 Adult Carcass    3133.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  740.925 Larval Midgut  (2034.6) Larval Hindgut  (892.6) Larval Malpighian Tubules  735.9 Larval Fat Body  (835.3) Larval Salivary Gland  (1432.3) Larval Trachea  (1151.925) Larval Carcass  612.675 Adult Head  (2787) Adult Eye  (1477.25) Adult Brain  726.2 Adult Thoracic-Abdominal Ganglion  (905) Adult Crop  (2778.2) Adult Midgut  (1393) Adult Hindgut  (1344.4) Adult Malpighian Tubules  (2323.2) Adult Fat Body  (3704.6) Adult Salivary Gland  (2127.2) Adult Heart  (2645.1) Adult VirginFemale Spermatheca  (3996.7) Adult InseminatedFemale Spermatheca  (3829.2) Adult Ovary  (920.3) Adult Testis  (1464.8) Adult Male Accessory Gland  (858.6) Adult Carcass  (3133.2) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    740.925 Larval Midgut  (2034.6) Larval Hindgut    892.6 Larval Malpighian Tubules    735.9 Larval Fat Body    835.3 Larval Salivary Gland  1432.3 Larval Trachea  1151.925 Larval Carcass    612.675 Adult Head  (2787) Adult Eye  1477.25 Adult Brain    726.2 Adult Thoracic-Abdominal Ganglion    905 Adult Crop  (2778.2) Adult Midgut  1393 Adult Hindgut  1344.4 Adult Malpighian Tubules  (2323.2) Adult Fat Body  (3704.6) Adult Salivary Gland  (2127.2) Adult Heart  (2645.1) Adult VirginFemale Spermatheca  (3996.7) Adult InseminatedFemale Spermatheca  (3829.2) Adult Ovary    920.3 Adult Testis  1464.8 Adult Male Accessory Gland    858.6 Adult Carcass  (3133.2) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    740.925 Larval Midgut    2034.6 Larval Hindgut    892.6 Larval Malpighian Tubules    735.9 Larval Fat Body    835.3 Larval Salivary Gland    1432.3 Larval Trachea    1151.925 Larval Carcass    612.675 Adult Head    2787 Adult Eye    1477.25 Adult Brain    726.2 Adult Thoracic-Abdominal Ganglion    905 Adult Crop    2778.2 Adult Midgut    1393 Adult Hindgut    1344.4 Adult Malpighian Tubules    2323.2 Adult Fat Body    3704.6 Adult Salivary Gland    2127.2 Adult Heart    2645.1 Adult VirginFemale Spermatheca    3996.7 Adult InseminatedFemale Spermatheca    3829.2 Adult Ovary    920.3 Adult Testis    1464.8 Adult Male Accessory Gland    858.6 Adult Carcass    3133.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2787   NA  Eye    1477.25   NA  Brain    726.2   740.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    905   NA  Crop    2778.2   2034.6  Midgut    1393   892.6  Hindgut    1344.4   735.9  Malpighian Tubules    2323.2   835.3  Fat Body    3704.6   1432.3  Salivary Gland    2127.2   NA  Heart    2645.1   1151.925  Trachea    NA   NA  VirginFemale Spermatheca    3996.7   NA  InseminatedFemale Spermatheca    3829.2   NA  Ovary    920.3   NA  Testis    1464.8   NA  Male Accessory Gland    858.6   612.675  Carcass    3133.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    14 central nervous system, pupae P8    12 head, virgin 1-day female    364 head, virgin 4-day female    219 head, virgin 20-day female    390 head, mated 1-day female    238 head, mated 4-day female    241 head, mated 20-day female    342 head, mated 1-day male    386 head, mated 4-day male    248 head, mated 20-day male    310 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    136 digestive system, 4-day adult    79 digestive system, 20-day adult    86 fat body, larvae L3 wandering    82 fat body, white prepupae    12 fat body, pupae P8    32 carcass, larvae L3 wandering    16 carcass, 1-day adult    289 carcass, 4-day adult    226 carcass, 20-day adult    244 ovary, virgin 4-day female    125 ovary, mated 4-day female    92 testis, mated 4-day male    561 accessory gland, mated 4-day male    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (59) central nervous system, larvae L3    14 central nervous system, pupae P8    12 head, virgin 1-day female  (364) head, virgin 4-day female  (219) head, virgin 20-day female  (390) head, mated 1-day female  (238) head, mated 4-day female  (241) head, mated 20-day female  (342) head, mated 1-day male  (386) head, mated 4-day male  (248) head, mated 20-day male  (310) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering  (29) digestive system, 1-day adult  (136) digestive system, 4-day adult  (79) digestive system, 20-day adult  (86) fat body, larvae L3 wandering  (82) fat body, white prepupae    12 fat body, pupae P8  (32) carcass, larvae L3 wandering    16 carcass, 1-day adult  (289) carcass, 4-day adult  (226) carcass, 20-day adult  (244) ovary, virgin 4-day female  (125) ovary, mated 4-day female  (92) testis, mated 4-day male  (561) accessory gland, mated 4-day male  (69) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    14 central nervous system, pupae P8    12 head, virgin 1-day female  (364) head, virgin 4-day female  (219) head, virgin 20-day female  (390) head, mated 1-day female  (238) head, mated 4-day female  (241) head, mated 20-day female  (342) head, mated 1-day male  (386) head, mated 4-day male  (248) head, mated 20-day male  (310) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    29 digestive system, 1-day adult  (136) digestive system, 4-day adult    79 digestive system, 20-day adult    86 fat body, larvae L3 wandering    82 fat body, white prepupae    12 fat body, pupae P8    32 carcass, larvae L3 wandering    16 carcass, 1-day adult  (289) carcass, 4-day adult  (226) carcass, 20-day adult  (244) ovary, virgin 4-day female  (125) ovary, mated 4-day female    92 testis, mated 4-day male  (561) accessory gland, mated 4-day male    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    14 central nervous system, pupae P8    12 head, virgin 1-day female    364 head, virgin 4-day female    219 head, virgin 20-day female    390 head, mated 1-day female    238 head, mated 4-day female    241 head, mated 20-day female    342 head, mated 1-day male    386 head, mated 4-day male    248 head, mated 20-day male    310 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    136 digestive system, 4-day adult    79 digestive system, 20-day adult    86 fat body, larvae L3 wandering    82 fat body, white prepupae    12 fat body, pupae P8    32 carcass, larvae L3 wandering    16 carcass, 1-day adult    289 carcass, 4-day adult    226 carcass, 20-day adult    244 ovary, virgin 4-day female    125 ovary, mated 4-day female    92 testis, mated 4-day male    561 accessory gland, mated 4-day male    69 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    14 central nervous system, pupae P8    12 head, virgin 1-day female    364 head, virgin 4-day female    219 head, virgin 20-day female    390 head, mated 1-day female    238 head, mated 4-day female    241 head, mated 20-day female    342 head, mated 1-day male    386 head, mated 4-day male    248 head, mated 20-day male    310 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    136 digestive system, 4-day adult    79 digestive system, 20-day adult    86 fat body, larvae L3 wandering    82 fat body, white prepupae    12 fat body, pupae P8    32 carcass, larvae L3 wandering    16 carcass, 1-day adult    289 carcass, 4-day adult    226 carcass, 20-day adult    244 ovary, virgin 4-day female    125 ovary, mated 4-day female    92 testis, mated 4-day male    561 accessory gland, mated 4-day male    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (59) central nervous system, larvae L3    14 central nervous system, pupae P8    12 head, virgin 1-day female  (364) head, virgin 4-day female  (219) head, virgin 20-day female  (390) head, mated 1-day female  (238) head, mated 4-day female  (241) head, mated 20-day female  (342) head, mated 1-day male  (386) head, mated 4-day male  (248) head, mated 20-day male  (310) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering  29 digestive system, 1-day adult  (136) digestive system, 4-day adult  (79) digestive system, 20-day adult  (86) fat body, larvae L3 wandering  (82) fat body, white prepupae    12 fat body, pupae P8  32 carcass, larvae L3 wandering    16 carcass, 1-day adult  (289) carcass, 4-day adult  (226) carcass, 20-day adult  (244) ovary, virgin 4-day female  (125) ovary, mated 4-day female  (92) testis, mated 4-day male  (561) accessory gland, mated 4-day male  (69) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    14 central nervous system, pupae P8    12 head, virgin 1-day female  (364) head, virgin 4-day female  (219) head, virgin 20-day female  (390) head, mated 1-day female  (238) head, mated 4-day female  (241) head, mated 20-day female  (342) head, mated 1-day male  (386) head, mated 4-day male  (248) head, mated 20-day male  (310) salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    29 digestive system, 1-day adult  136 digestive system, 4-day adult    79 digestive system, 20-day adult    86 fat body, larvae L3 wandering    82 fat body, white prepupae    12 fat body, pupae P8    32 carcass, larvae L3 wandering    16 carcass, 1-day adult  (289) carcass, 4-day adult  (226) carcass, 20-day adult  (244) ovary, virgin 4-day female  125 ovary, mated 4-day female    92 testis, mated 4-day male  (561) accessory gland, mated 4-day male    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    59 central nervous system, larvae L3    14 central nervous system, pupae P8    12 head, virgin 1-day female    364 head, virgin 4-day female    219 head, virgin 20-day female    390 head, mated 1-day female    238 head, mated 4-day female    241 head, mated 20-day female    342 head, mated 1-day male    386 head, mated 4-day male    248 head, mated 20-day male    310 salivary gland, larvae L3 wandering    8 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    29 digestive system, 1-day adult    136 digestive system, 4-day adult    79 digestive system, 20-day adult    86 fat body, larvae L3 wandering    82 fat body, white prepupae    12 fat body, pupae P8    32 carcass, larvae L3 wandering    16 carcass, 1-day adult    289 carcass, 4-day adult    226 carcass, 20-day adult    244 ovary, virgin 4-day female    125 ovary, mated 4-day female    92 testis, mated 4-day male    561 accessory gland, mated 4-day male    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    139 embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    41 embryo 16-18hr    142 embryo 18-20hr    280 embryo 20-22hr    328 embryo 22-24hr    475 larva L1    692 larva L2    1141 larva L3 12hr old    1068 larva L3 puffstage 1-2    153 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    56 white prepupae 24hr    48 pupae 2d postWPP    69 pupae 3d postWPP    93 pupae 4d postWPP    136 adult male 01day    460 adult male 05day    353 adult male 30day    289 adult female 01day    266 adult female 05day    223 adult female 30day    224 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (139) embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr  (41) embryo 16-18hr  (142) embryo 18-20hr  (280) embryo 20-22hr  (328) embryo 22-24hr  (475) larva L1  (692) larva L2  (1141) larva L3 12hr old  (1068) larva L3 puffstage 1-2  (153) larva L3 puffstage 3-6  (28) larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr  (56) white prepupae 24hr  (48) pupae 2d postWPP  (69) pupae 3d postWPP  (93) pupae 4d postWPP  (136) adult male 01day  (460) adult male 05day  (353) adult male 30day  (289) adult female 01day  (266) adult female 05day  (223) adult female 30day  (224) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (139) embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    41 embryo 16-18hr  (142) embryo 18-20hr  (280) embryo 20-22hr  (328) embryo 22-24hr  (475) larva L1  (692) larva L2  (1141) larva L3 12hr old  (1068) larva L3 puffstage 1-2  (153) larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    56 white prepupae 24hr    48 pupae 2d postWPP    69 pupae 3d postWPP    93 pupae 4d postWPP  (136) adult male 01day  (460) adult male 05day  (353) adult male 30day  (289) adult female 01day  (266) adult female 05day  (223) adult female 30day  (224) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    139 embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    41 embryo 16-18hr    142 embryo 18-20hr    280 embryo 20-22hr    328 embryo 22-24hr    475 larva L1    692 larva L2    1141 larva L3 12hr old    1068 larva L3 puffstage 1-2    153 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    56 white prepupae 24hr    48 pupae 2d postWPP    69 pupae 3d postWPP    93 pupae 4d postWPP    136 adult male 01day    460 adult male 05day    353 adult male 30day    289 adult female 01day    266 adult female 05day    223 adult female 30day    224 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    139 embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    41 embryo 16-18hr    142 embryo 18-20hr    280 embryo 20-22hr    328 embryo 22-24hr    475 larva L1    692 larva L2    1141 larva L3 12hr old    1068 larva L3 puffstage 1-2    153 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    56 white prepupae 24hr    48 pupae 2d postWPP    69 pupae 3d postWPP    93 pupae 4d postWPP    136 adult male 01day    460 adult male 05day    353 adult male 30day    289 adult female 01day    266 adult female 05day    223 adult female 30day    224 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (139) embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr  (41) embryo 16-18hr  (142) embryo 18-20hr  (280) embryo 20-22hr  (328) embryo 22-24hr  (475) larva L1  (692) larva L2  (1141) larva L3 12hr old  (1068) larva L3 puffstage 1-2  (153) larva L3 puffstage 3-6  28 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr  (56) white prepupae 24hr  (48) pupae 2d postWPP  (69) pupae 3d postWPP  (93) pupae 4d postWPP  (136) adult male 01day  (460) adult male 05day  (353) adult male 30day  (289) adult female 01day  (266) adult female 05day  (223) adult female 30day  (224) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  139 embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    41 embryo 16-18hr  142 embryo 18-20hr  (280) embryo 20-22hr  (328) embryo 22-24hr  (475) larva L1  (692) larva L2  (1141) larva L3 12hr old  (1068) larva L3 puffstage 1-2  (153) larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    56 white prepupae 24hr    48 pupae 2d postWPP    69 pupae 3d postWPP    93 pupae 4d postWPP  136 adult male 01day  (460) adult male 05day  (353) adult male 30day  (289) adult female 01day  (266) adult female 05day  (223) adult female 30day  (224) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    139 embryo 02-04hr    4 embryo 04-06hr    3 embryo 06-08hr    3 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    6 embryo 14-16hr    41 embryo 16-18hr    142 embryo 18-20hr    280 embryo 20-22hr    328 embryo 22-24hr    475 larva L1    692 larva L2    1141 larva L3 12hr old    1068 larva L3 puffstage 1-2    153 larva L3 puffstage 3-6    28 larva L3 puffstage 7-9    15 white prepupae new    13 white prepupae 12hr    56 white prepupae 24hr    48 pupae 2d postWPP    69 pupae 3d postWPP    93 pupae 4d postWPP    136 adult male 01day    460 adult male 05day    353 adult male 30day    289 adult female 01day    266 adult female 05day    223 adult female 30day    224 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    152 Schneider line 2 Sg4    506 embryonic 1182-4H    205 embryonic GM2    290 embryonic Kc167    283 embryonic S1    443 embryonic S3    521 leg disc CME L1    294 wing disc CME-W2    452 wing disc ML-DmD8    239 wing disc ML-DmD9    275 wing disc ML-DmD16-c3    293 wing disc ML-DmD21    1315 wing disc ML-DmD32    150 haltere disc ML-DmD17-c3    885 eye-antennal disc ML-DmD11    532 antennal disc ML-DmD20-c5    244 mixed discs ML-DmD4-c1    387 CNS ML-DmBG1-c1    211 CNS ML-DmBG2-c2    179 tumorous blood cells mbn2    139 ovary fGS/OSS    52 ovary OSC    182 ovary OSS    47 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (152) Schneider line 2 Sg4  (506) embryonic 1182-4H  (205) embryonic GM2  (290) embryonic Kc167  (283) embryonic S1  (443) embryonic S3  (521) leg disc CME L1  (294) wing disc CME-W2  (452) wing disc ML-DmD8  (239) wing disc ML-DmD9  (275) wing disc ML-DmD16-c3  (293) wing disc ML-DmD21  (1315) wing disc ML-DmD32  (150) haltere disc ML-DmD17-c3  (885) eye-antennal disc ML-DmD11  (532) antennal disc ML-DmD20-c5  (244) mixed discs ML-DmD4-c1  (387) CNS ML-DmBG1-c1  (211) CNS ML-DmBG2-c2  (179) tumorous blood cells mbn2  (139) ovary fGS/OSS  (52) ovary OSC  (182) ovary OSS  (47) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (152) Schneider line 2 Sg4  (506) embryonic 1182-4H  (205) embryonic GM2  (290) embryonic Kc167  (283) embryonic S1  (443) embryonic S3  (521) leg disc CME L1  (294) wing disc CME-W2  (452) wing disc ML-DmD8  (239) wing disc ML-DmD9  (275) wing disc ML-DmD16-c3  (293) wing disc ML-DmD21  (1315) wing disc ML-DmD32  (150) haltere disc ML-DmD17-c3  (885) eye-antennal disc ML-DmD11  (532) antennal disc ML-DmD20-c5  (244) mixed discs ML-DmD4-c1  (387) CNS ML-DmBG1-c1  (211) CNS ML-DmBG2-c2  (179) tumorous blood cells mbn2  (139) ovary fGS/OSS    52 ovary OSC  (182) ovary OSS    47 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    152 Schneider line 2 Sg4    506 embryonic 1182-4H    205 embryonic GM2    290 embryonic Kc167    283 embryonic S1    443 embryonic S3    521 leg disc CME L1    294 wing disc CME-W2    452 wing disc ML-DmD8    239 wing disc ML-DmD9    275 wing disc ML-DmD16-c3    293 wing disc ML-DmD21    1315 wing disc ML-DmD32    150 haltere disc ML-DmD17-c3    885 eye-antennal disc ML-DmD11    532 antennal disc ML-DmD20-c5    244 mixed discs ML-DmD4-c1    387 CNS ML-DmBG1-c1    211 CNS ML-DmBG2-c2    179 tumorous blood cells mbn2    139 ovary fGS/OSS    52 ovary OSC    182 ovary OSS    47 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    152 Schneider line 2 Sg4    506 embryonic 1182-4H    205 embryonic GM2    290 embryonic Kc167    283 embryonic S1    443 embryonic S3    521 leg disc CME L1    294 wing disc CME-W2    452 wing disc ML-DmD8    239 wing disc ML-DmD9    275 wing disc ML-DmD16-c3    293 wing disc ML-DmD21    1315 wing disc ML-DmD32    150 haltere disc ML-DmD17-c3    885 eye-antennal disc ML-DmD11    532 antennal disc ML-DmD20-c5    244 mixed discs ML-DmD4-c1    387 CNS ML-DmBG1-c1    211 CNS ML-DmBG2-c2    179 tumorous blood cells mbn2    139 ovary fGS/OSS    52 ovary OSC    182 ovary OSS    47 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (152) Schneider line 2 Sg4  (506) embryonic 1182-4H  (205) embryonic GM2  (290) embryonic Kc167  (283) embryonic S1  (443) embryonic S3  (521) leg disc CME L1  (294) wing disc CME-W2  (452) wing disc ML-DmD8  (239) wing disc ML-DmD9  (275) wing disc ML-DmD16-c3  (293) wing disc ML-DmD21  (1315) wing disc ML-DmD32  (150) haltere disc ML-DmD17-c3  (885) eye-antennal disc ML-DmD11  (532) antennal disc ML-DmD20-c5  (244) mixed discs ML-DmD4-c1  (387) CNS ML-DmBG1-c1  (211) CNS ML-DmBG2-c2  (179) tumorous blood cells mbn2  (139) ovary fGS/OSS  (52) ovary OSC  (182) ovary OSS  (47) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (152) Schneider line 2 Sg4  (506) embryonic 1182-4H  (205) embryonic GM2  (290) embryonic Kc167  (283) embryonic S1  (443) embryonic S3  (521) leg disc CME L1  (294) wing disc CME-W2  (452) wing disc ML-DmD8  (239) wing disc ML-DmD9  (275) wing disc ML-DmD16-c3  (293) wing disc ML-DmD21  (1315) wing disc ML-DmD32  (150) haltere disc ML-DmD17-c3  (885) eye-antennal disc ML-DmD11  (532) antennal disc ML-DmD20-c5  (244) mixed discs ML-DmD4-c1  (387) CNS ML-DmBG1-c1  (211) CNS ML-DmBG2-c2  (179) tumorous blood cells mbn2  139 ovary fGS/OSS    52 ovary OSC  (182) ovary OSS    47 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    152 Schneider line 2 Sg4    506 embryonic 1182-4H    205 embryonic GM2    290 embryonic Kc167    283 embryonic S1    443 embryonic S3    521 leg disc CME L1    294 wing disc CME-W2    452 wing disc ML-DmD8    239 wing disc ML-DmD9    275 wing disc ML-DmD16-c3    293 wing disc ML-DmD21    1315 wing disc ML-DmD32    150 haltere disc ML-DmD17-c3    885 eye-antennal disc ML-DmD11    532 antennal disc ML-DmD20-c5    244 mixed discs ML-DmD4-c1    387 CNS ML-DmBG1-c1    211 CNS ML-DmBG2-c2    179 tumorous blood cells mbn2    139 ovary fGS/OSS    52 ovary OSC    182 ovary OSS    47 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    34 heat shock, 4-day adult    211 Cadmium 50 mM 6 hrs, larvae L3    395 Cadmium 50 mM 12 hrs, larvae L3    132 Cadmium 50 mM 48 hrs, 4-day adult    247 Cadmium 100 mM 48 hrs, 4-day adult    93 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    69 Ethanol 2.5% 3 hrs, larvae L3    159 Ethanol 5% 3 hrs, larvae L3    612 Ethanol 10% 3 hrs, larvae L3    350 Caffeine 1.5 mg/ml 4 hrs, larvae L3    289 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    115 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    157 Paraquat 10 mM 48 hrs, 4-day adult    193 Rotenone 2 μg 12 hrs, larvae L3    274 Rotenone 8 μg 12 hrs, larvae L3    323 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (34) cold shock, 4-day adult  (34) heat shock, 4-day adult  (211) Cadmium 50 mM 6 hrs, larvae L3  (395) Cadmium 50 mM 12 hrs, larvae L3  (132) Cadmium 50 mM 48 hrs, 4-day adult  (247) Cadmium 100 mM 48 hrs, 4-day adult  (93) Copper 0.5 mM 12 hrs, larvae L3  (92) Copper 15 mM 48 hrs, 4-day adult  (35) Zinc 5 mM 12 hrs, larvae L3  (67) Zinc 4.5 mM 48 hrs, 4-day adult  (69) Ethanol 2.5% 3 hrs, larvae L3  (159) Ethanol 5% 3 hrs, larvae L3  (612) Ethanol 10% 3 hrs, larvae L3  (350) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (289) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (115) Caffeine 25 mg/ml 48 hrs, 4-day adult  (47) Paraquat 5 mM 48 hrs, 4-day adult  (157) Paraquat 10 mM 48 hrs, 4-day adult  (193) Rotenone 2 μg 12 hrs, larvae L3  (274) Rotenone 8 μg 12 hrs, larvae L3  (323) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    34 heat shock, 4-day adult  (211) Cadmium 50 mM 6 hrs, larvae L3  (395) Cadmium 50 mM 12 hrs, larvae L3  (132) Cadmium 50 mM 48 hrs, 4-day adult  (247) Cadmium 100 mM 48 hrs, 4-day adult    93 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    69 Ethanol 2.5% 3 hrs, larvae L3  (159) Ethanol 5% 3 hrs, larvae L3  (612) Ethanol 10% 3 hrs, larvae L3  (350) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (289) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (115) Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult  (157) Paraquat 10 mM 48 hrs, 4-day adult  (193) Rotenone 2 μg 12 hrs, larvae L3  (274) Rotenone 8 μg 12 hrs, larvae L3  (323) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    34 heat shock, 4-day adult    211 Cadmium 50 mM 6 hrs, larvae L3    395 Cadmium 50 mM 12 hrs, larvae L3    132 Cadmium 50 mM 48 hrs, 4-day adult    247 Cadmium 100 mM 48 hrs, 4-day adult    93 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    69 Ethanol 2.5% 3 hrs, larvae L3    159 Ethanol 5% 3 hrs, larvae L3    612 Ethanol 10% 3 hrs, larvae L3    350 Caffeine 1.5 mg/ml 4 hrs, larvae L3    289 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    115 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    157 Paraquat 10 mM 48 hrs, 4-day adult    193 Rotenone 2 μg 12 hrs, larvae L3    274 Rotenone 8 μg 12 hrs, larvae L3    323 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    34 heat shock, 4-day adult    211 Cadmium 50 mM 6 hrs, larvae L3    395 Cadmium 50 mM 12 hrs, larvae L3    132 Cadmium 50 mM 48 hrs, 4-day adult    247 Cadmium 100 mM 48 hrs, 4-day adult    93 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    69 Ethanol 2.5% 3 hrs, larvae L3    159 Ethanol 5% 3 hrs, larvae L3    612 Ethanol 10% 3 hrs, larvae L3    350 Caffeine 1.5 mg/ml 4 hrs, larvae L3    289 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    115 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    157 Paraquat 10 mM 48 hrs, 4-day adult    193 Rotenone 2 μg 12 hrs, larvae L3    274 Rotenone 8 μg 12 hrs, larvae L3    323 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (34) cold shock, 4-day adult  (34) heat shock, 4-day adult  (211) Cadmium 50 mM 6 hrs, larvae L3  (395) Cadmium 50 mM 12 hrs, larvae L3  (132) Cadmium 50 mM 48 hrs, 4-day adult  (247) Cadmium 100 mM 48 hrs, 4-day adult  (93) Copper 0.5 mM 12 hrs, larvae L3  (92) Copper 15 mM 48 hrs, 4-day adult  (35) Zinc 5 mM 12 hrs, larvae L3  (67) Zinc 4.5 mM 48 hrs, 4-day adult  (69) Ethanol 2.5% 3 hrs, larvae L3  (159) Ethanol 5% 3 hrs, larvae L3  (612) Ethanol 10% 3 hrs, larvae L3  (350) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (289) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (115) Caffeine 25 mg/ml 48 hrs, 4-day adult  (47) Paraquat 5 mM 48 hrs, 4-day adult  (157) Paraquat 10 mM 48 hrs, 4-day adult  (193) Rotenone 2 μg 12 hrs, larvae L3  (274) Rotenone 8 μg 12 hrs, larvae L3  (323) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    34 heat shock, 4-day adult  (211) Cadmium 50 mM 6 hrs, larvae L3  (395) Cadmium 50 mM 12 hrs, larvae L3  132 Cadmium 50 mM 48 hrs, 4-day adult  (247) Cadmium 100 mM 48 hrs, 4-day adult    93 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    69 Ethanol 2.5% 3 hrs, larvae L3  (159) Ethanol 5% 3 hrs, larvae L3  (612) Ethanol 10% 3 hrs, larvae L3  (350) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (289) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  115 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult  (157) Paraquat 10 mM 48 hrs, 4-day adult  (193) Rotenone 2 μg 12 hrs, larvae L3  (274) Rotenone 8 μg 12 hrs, larvae L3  (323) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    34 cold shock, 4-day adult    34 heat shock, 4-day adult    211 Cadmium 50 mM 6 hrs, larvae L3    395 Cadmium 50 mM 12 hrs, larvae L3    132 Cadmium 50 mM 48 hrs, 4-day adult    247 Cadmium 100 mM 48 hrs, 4-day adult    93 Copper 0.5 mM 12 hrs, larvae L3    92 Copper 15 mM 48 hrs, 4-day adult    35 Zinc 5 mM 12 hrs, larvae L3    67 Zinc 4.5 mM 48 hrs, 4-day adult    69 Ethanol 2.5% 3 hrs, larvae L3    159 Ethanol 5% 3 hrs, larvae L3    612 Ethanol 10% 3 hrs, larvae L3    350 Caffeine 1.5 mg/ml 4 hrs, larvae L3    289 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    115 Caffeine 25 mg/ml 48 hrs, 4-day adult    47 Paraquat 5 mM 48 hrs, 4-day adult    157 Paraquat 10 mM 48 hrs, 4-day adult    193 Rotenone 2 μg 12 hrs, larvae L3    274 Rotenone 8 μg 12 hrs, larvae L3    323 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_10 mE1_20_mRNA_expression_cluster_15
External Data & Images
Linkouts	BDGP expression data • PC00469 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0012036 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3752-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Aldh Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 AldhGD11064 viable Aldh4 Aldh8 Aldh17 Aldh24 Other Phenotypes Allele chemical sensitive | adult stage (with Df(2L)N22-14) Aldh4 Aldh8 Aldh17 Aldh24 chemical sensitive | larval stage Aldh17 Aldh24 oxidative stress response defective Aldh17 Aldh24 starvation stress response defective Aldh17 Aldh24 visible, with Scer\GAL4pnr-MD237 AldhGD11064 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 AldhGD11064
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of Aldh Class Mutagen Stocks Known lesion Aldhc04714 1 -- Aldhd00155 P-element activity 1 -- AldhKG02748 P-element activity 1 Yes Aldh17 loss of function allele Delta2-3 0 Yes Aldh24 loss of function allele Delta2-3 0 Yes Aldh4 loss of function allele Delta2-3 0 Yes Aldh8 loss of function allele Delta2-3 0 Yes AldhLeu natural population 0 -- AldhPhe natural population 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Aldh Class Mutagen Stocks Known lesion AldhGD11064 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AldhHMS01399 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes AldhNIG.3752R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)N22-14 (Fry and Saweikis, 2006)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11064} NA P{NIG.3752R} NA P{TRiP.HMS01399} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}AldhKG02748 NA PBac{PB}Aldhc04714 NA insertion of mobile activating element P{XP}Aldhd00155 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
acetaldehyde dehydrogenase (acetylating) activity inferred from direct assay (Leal and Barbancho, 1992) aldehyde dehydrogenase (NAD) activity inferred from direct assay (Leal and Barbancho, 1993, Rothacker and Ilg, 2008)
Biological Process
CV term Evidence References
acetaldehyde metabolic process inferred from mutant phenotype (Leal and Barbancho, 1992) response to ethanol inferred from mutant phenotype (Fry and Saweikis, 2006)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Leal and Barbancho, 1993) lipid particle inferred from direct assay (Beller et al., 2006, Cermelli et al., 2006) mitochondrion inferred from direct assay (Leal and Barbancho, 1993, Alonso et al., 2005)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
aldehyde dehydrogenase (NAD) activity inferred from sequence or structural similarity with UniProtKB:P05091 (Sardiello et al., 2003.6.11) inferred from sequence or structural similarity with UniProtKB:P11884 (FlyBase, 1992-)
Biological Process
CV term Evidence References
oxidation-reduction process inferred from electronic annotation with InterPro:IPR015590, InterPro:IPR016160, InterPro:IPR016161, InterPro:IPR016162, InterPro:IPR016163 (FlyBase Curators et al., 2004-) pyruvate metabolic process inferred from sequence or structural similarity with UniProtKB:P05091 (Sardiello et al., 2003.6.11)
Cellular Component
CV term Evidence References
mitochondrial matrix inferred from sequence or structural similarity with UniProtKB:P05091 (Sardiello et al., 2003.6.11) mitochondrion inferred from sequence or structural similarity with UniProtKB:P11884 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Aldh - Chc experimental knowledge based (Guruharsha et al., 2011) Aldh - Gale experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Aldh allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60360 DroID - A comprehensive database of gene and protein interactions. • FBgn0012036 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34256
Orthologs
OrthoDB Orthologs (82) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6PG6KH Dipteran inclusive ortholog search EOG63XVBS Insect inclusive ortholog search EOG6SXM81 Arthropod inclusive ortholog search EOG6VHHNH Metazoa inclusive ortholog search EOG6R873R
Orthologs in Drosophila Species (EOG6PG6KH)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Aldh     Drosophila simulans   Dsim\GD23600 Y   Drosophila sechellia   Dsec\GM17439 Y   Drosophila erecta   Dere\GG25345 Y   Drosophila yakuba   Dyak\GE18837 Y   Drosophila ananassae   Dana\GF22728 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17661 Y   Drosophila persimilis   Dper\GL26145 Y   Drosophila willistoni   Dwil\GK24201 Y   Drosophila virilis   Dvir\GJ17859 Y   Drosophila mojavensis   Dmoj\GI17663 Y   Drosophila grimshawi   Dgri\GH13324
Orthologs in non-Drosophila Dipterans (EOG63XVBS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009029   Anopheles gambiae Malaria mosquito  Agam\AGAP003652   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007198
Orthologs in non-Dipteran Insects (EOG6SXM81)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51283 Y Apis mellifera Western honey bee  Amel\GB49240 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011047 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG013575 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG011046 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21264 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17696 Y Atta cephalotes Leafcutter ant  Acep\ACEP10419 Y Atta cephalotes Leafcutter ant  Acep\ACEP19468 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14216 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12755 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17427 Y Linepithema humile Argentine ant  Lhum\LH17105 Y Linepithema humile Argentine ant  Lhum\LH11078 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB21515 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20582 Y Solenopsis invicta Red fire ant  Sinv\SINV20765 Y Solenopsis invicta Red fire ant  Sinv\SINV14675 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003925 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI009744 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002457 Y Bombyx mori Silkmoth  Bmor\BGIBMGA010403 Y Pediculus humanus Human body louse  Phum\PHUM307790 Y Pediculus humanus Human body louse  Phum\PHUM222120 Y Tribolium castaneum Red flour beetle  Tcas\TC011192 Y Tribolium castaneum Red flour beetle  Tcas\TC000960 Y
Orthologs in non-Insect Arthropods (EOG6VHHNH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Rdbp Y Daphnia pulex Water flea  Dpux\HSD17B11 Y Daphnia pulex Water flea  Dpux\JGI_V11_215225 Y Ixodes scapularis Deer tick  Isca\ISCW023288 Y Ixodes scapularis Deer tick  Isca\ISCW014613 Y Ixodes scapularis Deer tick  Isca\ISCW012082 Y
Orthologs in non-Arthropod Metazoa (EOG6R873R)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\K04F1.15 Y Caenorhabditis elegans Nematode  Cele\alh-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007283gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023801gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007284gn Y Danio rerio Zebrafish  Drer\ENSDARG00000028087 Y Danio rerio Zebrafish  Drer\aldh1a2 Y Danio rerio Zebrafish  Drer\aldh2l Y Danio rerio Zebrafish  Drer\ENSDARG00000090766 Y Danio rerio Zebrafish  Drer\aldh1a3 Y Danio rerio Zebrafish  Drer\aldh2a Y Xenopus tropicalis Western clawed frog  Xtro\aldh1b1 Y Xenopus tropicalis Western clawed frog  Xtro\aldh2 Y Xenopus tropicalis Western clawed frog  Xtro\aldh1a1 Y Xenopus tropicalis Western clawed frog  Xtro\aldh1a2 Y Xenopus tropicalis Western clawed frog  Xtro\aldh1a3 Y Gallus gallus Domestic chicken  Ggal\ALDH1A1 Y Gallus gallus Domestic chicken  Ggal\ALDH1A2 Y Gallus gallus Domestic chicken  Ggal\ALDH2 Y Gallus gallus Domestic chicken  Ggal\ALDH6 Y Mus musculus House mouse  Mmus\Aldh1b1 Y Mus musculus House mouse  Mmus\Aldh1a7 Y Mus musculus House mouse  Mmus\Aldh1a2 Y Mus musculus House mouse  Mmus\Aldh1a3 Y Mus musculus House mouse  Mmus\Aldh1a1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000001344 Y Rattus norvegicus Norway rat  Rnor\Aldh1a3 Y Rattus norvegicus Norway rat  Rnor\Aldh1a2 Y Rattus norvegicus Norway rat  Rnor\Aldh1b1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000017878 Y Rattus norvegicus Norway rat  Rnor\Aldh1a1 Y Homo sapiens Human  Hsap\ENSG00000137124 Y Homo sapiens Human  Hsap\ALDH2 Y Homo sapiens Human  Hsap\ALDH1A1 Y Homo sapiens Human  Hsap\ALDH1A2 Y
Human Orthologs (4)
Gene OMIM HGNC Hsap\ENSG00000137124     Hsap\ALDH2     Hsap\ALDH1A1     Hsap\ALDH1A2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23600 Drosophila sechellia Dsec\GM17439 Drosophila erecta Dere\GG25345 Drosophila yakuba Dyak\GE18837 Drosophila ananassae Dana\GF22728 Drosophila pseudoobscura pseudoobscura Dpse\GA17661 Drosophila persimilis Dper\GL26145 Drosophila willistoni Dwil\GK24201 Drosophila virilis Dvir\GJ17859 Drosophila mojavensis Dmoj\GI17663 Drosophila grimshawi Dgri\GH13227
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	12900 y1 w67c23; P{SUPor-P}AldhKG02748 34989 y1 sc* v1; P{TRiP.HMS01399}attP2
Harvard	- P{XP}Aldhd00155 - PBac{PB}Aldhc04714
VDRC	v21707 w1118 P{GD11064}v21707
Genomic Clones ( 2 )
	BACR20B09 BACR26G12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 236 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH22814
Other clones	MIP28901
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02447 AT08010 AT19454 AT20611 AT20907 AT22536 AT23435 AT25830 AT29208 AT30116 GH01216 GH02663 GH02763 GH02871 GH03634 GH04070 GH04381 GH04720 GH05673 GH05791 GH06724 GH07141 GH07339 GH09829 GH10428 GH10881 GH11062 GH11966 GH12270 GH12342 GH13010 GH13225 GH15847 GH15978 GH16776 GH17714 GH17814 GH18469 GH18652 GH19430 GH19815 GH20133 GH20390 GH21403 GH21602 GH22620 GH22782 GH23855 GH24209 GH24359 GH25504 GH27631 GH27633 GH28390 GH28767 GM02301 GM04337 GM09759 GM10444 GM15684 GM18387 GM28881 GM31730 HL01365 HL02450 HL02710 HL04287 HL07345 LD22166 LD23080 LP03091 LP03474 LP05022 LP06781 LP09620 LP11406 LP11595 LP12025 LP20063 LP23240 RE14273 RE21014 RE23873 RE25069 RE25881 RE27076 RE30290 RE30541 RE41220 RE43647 RE45680 RE46466 RE46909 RE48857 RE50757 RE55875 RE61764 RE62413 RE66794 RE67961 RE72542 RE74393 RE74580 RH02946 RH03523 RH03876 RH05527 RH05531 RH06145 RH06167 RH07862 RH44268 RH45414 RH46058 RH52628 RH54439 RH56287 RH68933 RH73673 RH74130 SD02531 SD07157 SD07519 SD10711 SD12078 SD14151 SD21208 SD24356 SD26409
Other clones	52802 55200 56290 57994 58818 69838 160484 179258 191324 297690 557076 bs01g07 bs04f06 bs10b01 bs12h08 bs21c11 bs31h10 bs62e09 bs84a09 bs86h12 CK01.132C.F2 CK01.142B.G8 CK01.146B.C10 CK01.169A.H9 CK01.169C.H9 Dmel_dig_014961_0626_1025 Dmel_neb_011746_0573_1766 Dmel_neb_011983_0684_1432 Dmel_neb_014753_0889_3442 Dmel_neb_015632_0940_1354 EC40895 EK101053 EK103431 EK104029 EK117308 EK118960 EK168524 EK180222 EK182528 EK182741 EK285612 EN12013 EN14330 GH03627 GH09457 GH09575 GH12707 GH15633 GH22461 GH23936 GH28708 GM13277 HL01203 HL02731 HL03821 HL04215 HL06507 IP10042 LP06266 RE01128 RE02270 RE05940 RE12560 RE17355 RE19537 RE19594 RE19703 RE20850 RE31313 RE35383 RE35894 RE40741 RE45164 RE45343 RE68862 RH10844 RH11352 RH17090 RH20127 RH20243 RH24871 RH26006 RH29583 RH30160 RH30554 RH31569 RH32663 RH33428 RH36940 RH37440 RH37627 RH37709 RH37824 RH37902 RH42809 RH46574 RH48429 RH48915 RH59458 RH61035 RH64822 RH65978 RH70754 RH71751 RP003031335
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0012036 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34256
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Aldh CG3752 (Fry et al., 2005)
Additional comments
Other Comments
	Results are opposed to those of Lietaert, Experientia 38:651 and Lietaert, Experientia 41:57, who concluded that the ALDH activity was mainly in the mitochondria. (Leal and Barbancho, 1993) Subcellular localization of the aldehyde dehydrogenase activity from the ALDH enzyme was studied in wild type and Adhn4 adults. Aldehyde dehydrogenase activities from Adh and Aldh gene products are selectively inhibited by cyanimide or acetone, respectively. Contrary to the situation in larvae, in adults the ALDH activity from the Aldh gene product is mainly in the cytosolic, as opposed to the mitochondrial, fraction. Although larvae and adults use different ALDH activities to detoxify acetaldehyde (from Adh and Aldh encoded enzymes, respectively) both activities are cytosolic. (Leal and Barbancho, 1993) In adults, as opposed to larvae, acetaldehyde is mainly oxidised into acetate by means of Aldh enzymes. The reducing activity of the Adh enzyme, which transforms acetaldehyde into ethanol, also plays an essential role in the detoxification of acetaldehyde. (Leal and Barbancho, 1992) The role of Adh, Aldh and Aldox-1 in alcohol/aldehyde metabolism in D.melanogaster has been studied. (Anderson and Barnett, 1991) The effect of variation of Adh and Aldh has on the flux from 14C-ethanol to lipids is examined in third-instar larvae. (Heinstra and Geer, 1991) Aldh gene product is present in larvae but the activity of this enzyme differs from the ALDH activity of the Adh gene product. Studies of the flux of ethanol into lipid suggested that more than 75% of the oxidation of acetaldehyde in wild type larvae is catalysed by Adh product. (Heinstra et al., 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_135441 NM_001273361 RefSeq (Proteins) • NP_609285 NP_001260290 DDBJ / EMBL / GenBank • AA568034 AAF52769 AGB92825 AI297324 AI944470 AI944723 AI945197 AI945440 AI946136 AI946857 BH214611 CZ471415 Entrez Gene - A searchable database of RefSeq genes. • 34256 UniProtKB/TrEMBL • Q9VLC5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Aldehyde dehydrogenase domain (IPR015590) Aldehyde dehydrogenase, conserved site (IPR016160) Aldehyde/histidinol dehydrogenase (IPR016161) Aldehyde dehydrogenase, N-terminal (IPR016162) Aldehyde dehydrogenase, C-terminal (IPR016163) MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins • MTDROME03752 BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • PC00469
Linkouts
	BioGRID - A database of protein and genetic interactions • 60360 DroID - A comprehensive database of gene and protein interactions. • FBgn0012036 DRSC - Results from RNAi screens. • FBgn0012036 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0012036 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3752-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0012036 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34256 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34256 modMine - Data generated by the modENCODE project. • FBgn0012036
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	146084_at (Kristensen et al., 2005) ACDH (Glassman et al., 1968) ALDH (Leal and Barbancho, 1992, Fry and Saweikis, 2006, Liu et al., 2009) Aldh (Beller et al., 2006, Cermelli et al., 2006, Chen et al., 2012, Gallach et al., 2010, Ranade et al., 2008, O'Keefe et al., 2011, Rothacker and Ilg, 2008, Montooth et al., 2006, Halme et al., 2010, Fry et al., 2008, Wasbrough et al., 2010, Chakraborty and Fry, 2011, Yampolsky et al., 2012, Japanese National Institute of Genetics, 2012.5.21) ALDHA1 (Wishart et al., 2012) CG3752 (Fry et al., 2005, Cermelli et al., 2006, Mosallanejad et al., 2010, Dorus et al., 2006, O'Keefe et al., 2011, Rothacker and Ilg, 2008, Liu et al., 2009, Haussmann et al., 2008, Ni et al., 2011.7.19, Cammarato et al., 2011) CG 3752 (Alonso et al., 2005)
Name Synonym	Acetaldehyde dehydrogenase (Seegmiller et al., 2002, Heinstra et al., 1989, Cermelli et al., 2006) acetaldehyde dehydrogenase (Montooth et al., 2006) Aldehyde dehydrogenase (Leal and Barbancho, 1993, Anderson and Barnett, 1991, Fry and Saweikis, 2006, Gonsalves et al., 2011, Liu et al., 2009, Halme et al., 2010, Robinson et al., 2010, Cammarato et al., 2011) aldehyde dehydrogenase (O'Keefe et al., 2011, Culwell et al., 2008)
Secondary FlyBase IDs
	FBgn0032114
References ( 60 )
Generate a list of	All references relating to this gene ( 60 )
List References by type	Research paper  ( 30 ) Supplementary material  ( 10 ) Review  ( 2 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 7 )
	Chen et al., 2012, Cell Death Differ. 19(10): 1655--1663 Effectors of alcohol-induced cell killing in Drosophila. [FBrf0219410] Defays and Bertoli, 2012, Alcohol 46(8): 737--745 Quantitative trait loci for response to ethanol in an intercontinental set of recombinant inbred lines of Drosophila melanogaster. [FBrf0220080] Wishart et al., 2012, PLoS Genet. 8(8): e1002936 Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo. [FBrf0219374] Yampolsky et al., 2012, Mol. Ecol. 21(17): 4287--4299 Evolution of gene expression and expression plasticity in long-term experimental populations of Drosophila melanogaster maintained under constant and variable ethanol stress. [FBrf0219282] Chakraborty and Fry, 2011, Chem. Biol. Interact. 191(1-3): 296--302 Drosophila lacking a homologue of mammalian ALDH2 have multiple fitness defects. [FBrf0213750] Gonsalves et al., 2011, BMC Genomics 12: 475 Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster. [FBrf0216487] O'Keefe et al., 2011, Hum. Mol. Genet. 20(3): 497--509 Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species. [FBrf0212691] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...