Acetaldehyde dehydrogenase
Please see the JBrowse view of Dmel\Aldh for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Gene model reviewed during 6.61
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Aldh using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Comment: anlage in statu nascendi
Acetaldeyhde dehyrogenase activity from the Aldh gene is mainly cytosolic in adults though some is located in the mitochondria.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Aldh in JBrowse2-35
2-30.2
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Results are opposed to those of Lietaert, Experientia 38:651 and Lietaert, Experientia 41:57 , who concluded that the ALDH activity was mainly in the mitochondria.
Subcellular localization of the aldehyde dehydrogenase activity from the ALDH enzyme was studied in wild type and Adhn4 adults. Aldehyde dehydrogenase activities from Adh and Aldh gene products are selectively inhibited by cyanimide or acetone, respectively. Contrary to the situation in larvae, in adults the ALDH activity from the Aldh gene product is mainly in the cytosolic, as opposed to the mitochondrial, fraction. Although larvae and adults use different ALDH activities to detoxify acetaldehyde (from Adh and Aldh encoded enzymes, respectively) both activities are cytosolic.
The role of Adh, Aldh and Aldox-1 in alcohol/aldehyde metabolism in D.melanogaster has been studied.
Source for merge of: Aldh CG3752