FB2025_02 , released April 17, 2025
Gene: Dmel\Aldh
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General Information
Symbol
Dmel\Aldh
Species
D. melanogaster
Name
Aldehyde dehydrogenase
Annotation Symbol
CG3752
Feature Type
protein_coding_gene
FlyBase ID
FBgn0012036
Gene Model Status
Current
Stock Availability
10 publicly available
Enzyme Name (EC)
aldehyde dehydrogenase (NAD(+)) (1.2.1.3)
Gene Summary
Aldehyde dehydrogenase (Aldh) encodes an NAD[+] dependent mitochondrial aldehyde dehydrogenase. Its functions include detoxifying endogenous aldehydes generated by lipid peroxidation, and detoxifying acetaldehyde derived from dietary ethanol. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Acetaldehyde dehydrogenase

Key Links
Genomic Location
Cytogenetic map
30B1-30B1
Sequence location
Recombination map
2-35
RefSeq locus
NT_033779 REGION:9387389..9391567
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables aldehyde dehydrogenase (NAD+) activity
inferred from mutant phenotype
(Chakraborty and Fry, 2016)
inferred from direct assay
(Rothacker and Ilg, 2008, Leal and Barbancho, 1993, Leal and Barbancho, 1992)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables aldehyde dehydrogenase (NAD+) activity
inferred from biological aspect of ancestor with PANTHER:PTN000192421
(GO Reference Genome Project, 2011-)
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
inferred from electronic annotation with InterPro:IPR016163
(InterPro Project Members, 2004-)
enables oxidoreductase activity
(InterPro Project Members, 2004-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in acetaldehyde metabolic process
inferred from mutant phenotype
(Leal and Barbancho, 1992)
involved_in response to ethanol
inferred from mutant phenotype
(Fry and Saweikis, 2006)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Leal and Barbancho, 1993)
located_in mitochondrion
inferred from high throughput direct assay
(Tan et al., 2009, Alonso et al., 2005)
inferred from direct assay
(Leal and Barbancho, 1993)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in mitochondrial matrix
inferred from sequence or structural similarity with UniProtKB:P11884
(Gene Ontology Curators, 2002-)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
aldehyde dehydrogenase (NAD+) activity
an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+) (1.2.1.3)
RHEA 16185:
Summaries
Gene Snapshot
Aldehyde dehydrogenase (Aldh) encodes an NAD[+] dependent mitochondrial aldehyde dehydrogenase. Its functions include detoxifying endogenous aldehydes generated by lipid peroxidation, and detoxifying acetaldehyde derived from dietary ethanol. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
ALDEHYDE DEHYDROGENASES (NAD-DEPENDENT) -
Aldehyde dehydrogenases are capable of catalyzing oxidation of a wide range of aldehydes, thereby protecting cells from toxic aldehydes generated by lipid peroxidation within mitochondria or acetaldehyde derived from dietary ethanol. (Adapted from FBrf0227990.)
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Aldh for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VLC5)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Gene model reviewed during 6.61

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Aldh-RA
FBtr0079806
NM_135441
2070
520
Aldh-RB
FBtr0332597
NM_001273361
1900
520
Aldh-RC
FBtr0482695
1798
520
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Aldh-PA
FBpp0079406
57.0
520
6.79
Q9VLC5
NP_609285
AAF52769
Aldh-PB
FBpp0304847
57.0
520
6.79
Q9VLC5
NP_001260290
AGB92825
Aldh-PC
FBpp0428615
57.0
520
6.79
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

520 aa isoforms: Aldh-PA, Aldh-PB, Aldh-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Aldh using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

3.37

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010, Dorus et al., 2006)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data

Acetaldeyhde dehyrogenase activity from the Aldh gene is mainly cytosolic in adults though some is located in the mitochondria.

(Leal and Barbancho, 1993)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Leal and Barbancho, 1993)
located_in mitochondrion
inferred from high throughput direct assay
(Tan et al., 2009, Alonso et al., 2005)
inferred from direct assay
(Leal and Barbancho, 1993)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Aldh in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 13 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Aldh
Transgenic constructs containing regulatory region of Aldh
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)N22-14
(Fry and Saweikis, 2006)
Inferred from location ( 5 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (18)
Hsap\ALDH2
14 of 14
Yes
Yes
Hsap\ALDH1B1
12 of 14
No
Yes
Hsap\ALDH1A1
8 of 14
No
No
Hsap\ALDH1A2
8 of 14
No
No
Hsap\ALDH1A3
8 of 14
No
Yes
Hsap\ALDH1L1
3 of 14
No
No
4  
Hsap\ALDH1L2
3 of 14
No
No
Hsap\ALDH9A1
3 of 14
No
No
Hsap\ALDH3A1
2 of 14
No
No
2  
Hsap\ALDH3A2
2 of 14
No
No
1  
Hsap\ALDH3B1
2 of 14
No
No
Hsap\ALDH3B2
2 of 14
No
No
1  
Hsap\ALDH4A1
2 of 14
No
No
Hsap\ALDH5A1
2 of 14
No
No
1  
Hsap\ALDH7A1
2 of 14
No
No
Hsap\ALDH8A1
2 of 14
No
No
Hsap\ALDH16A1
2 of 14
No
No
Hsap\ALDH6A1
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (19)
Rnor\Aldh2
14 of 14
Yes
Yes
Rnor\Aldh1b1
12 of 14
No
Yes
Rnor\Aldh1a1
8 of 14
No
No
Rnor\Aldh1a2
7 of 14
No
No
Rnor\Aldh1a3
7 of 14
No
Yes
Rnor\Aldh1a7
7 of 14
No
Yes
Rnor\Aldh1l1
3 of 14
No
No
Rnor\Aldh1l2
3 of 14
No
No
Rnor\Aldh9a1
3 of 14
No
Yes
Rnor\Aldh3a1
2 of 14
No
No
Rnor\Aldh3a2
2 of 14
No
No
Rnor\Aldh3b1
2 of 14
No
No
Rnor\Aldh5a1
2 of 14
No
No
Rnor\Aldh7a1
2 of 14
No
No
Rnor\Aldh16a1
2 of 14
No
No
Rnor\Aldh4a1
1 of 14
No
No
Rnor\Aldh6a1
1 of 14
No
No
Rnor\Aldh8a1
1 of 14
No
No
Rnor\LOC688778
1 of 14
No
No
Mus musculus (laboratory mouse) (21)
Mmus\Aldh2
14 of 14
Yes
Yes
Mmus\Aldh1b1
11 of 14
No
Yes
Mmus\Aldh1a2
8 of 14
No
No
Mmus\Aldh1a3
8 of 14
No
Yes
Mmus\Aldh1a7
8 of 14
No
No
Mmus\Aldh1a1
7 of 14
No
Yes
Mmus\Aldh1l1
3 of 14
No
No
Mmus\Aldh1l2
3 of 14
No
No
Mmus\Aldh9a1
3 of 14
No
Yes
Mmus\Aldh3a1
2 of 14
No
No
Mmus\Aldh3a2
2 of 14
No
No
Mmus\Aldh3b1
2 of 14
No
No
Mmus\Aldh3b2
2 of 14
No
No
Mmus\Aldh3b3
2 of 14
No
No
Mmus\Aldh4a1
2 of 14
No
No
Mmus\Aldh5a1
2 of 14
No
No
Mmus\Aldh7a1
2 of 14
No
No
Mmus\Aldh8a1
2 of 14
No
Yes
Mmus\Aldh6a1
1 of 14
No
No
Mmus\Aldh16a1
1 of 14
No
No
Mmus\E030003E18Rik
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (15)
Xtro\aldh1b1
9 of 13
Yes
Yes
Xtro\aldh2
8 of 13
No
Yes
Xtro\aldh1a1
4 of 13
No
Yes
Xtro\aldh1a2
4 of 13
No
Yes
Xtro\aldh1a3
3 of 13
No
Yes
Xtro\aldh1l1
2 of 13
No
No
Xtro\aldh1l2
1 of 13
No
No
Xtro\aldh3b1
1 of 13
No
No
Xtro\aldh7a1
1 of 13
No
No
Xtro\aldh8a1
1 of 13
No
No
Xtro\aldh9a1
1 of 13
No
Yes
Xtro\aldh16a1
1 of 13
No
Yes
Xtro\elp3
1 of 13
No
No
Xtro\mctp1
1 of 13
No
No
Xtro\sugt1
1 of 13
No
No
Danio rerio (Zebrafish) (21)
Drer\aldh2.1
14 of 14
Yes
Yes
Drer\aldh2.2
13 of 14
No
Yes
Drer\aldh1a2
8 of 14
No
No
Drer\aldh1a3
8 of 14
No
Yes
Drer\wu:fb14d09
8 of 14
No
Yes
Drer\aldh1l2
3 of 14
No
No
Drer\aldh9a1a.1
3 of 14
No
No
Drer\aldh9a1a.2
3 of 14
No
No
Drer\aldh9a1b
3 of 14
No
No
Drer\aldh1l1
2 of 14
No
No
Drer\aldh3a2a
2 of 14
No
No
Drer\aldh3a2b
2 of 14
No
No
Drer\aldh3b1
2 of 14
No
No
Drer\aldh7a1
2 of 14
No
No
Drer\aldh8a1
2 of 14
No
No
Drer\aldh16a1
2 of 14
No
No
Drer\aldh3a1
1 of 14
No
No
Drer\aldh3b2
1 of 14
No
No
Drer\aldh4a1
1 of 14
No
No
Drer\aldh5a1
1 of 14
No
No
Drer\aldh6a1
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (12)
Cele\alh-2
13 of 14
Yes
Yes
Cele\alh-1
12 of 14
No
Yes
Cele\alh-3
3 of 14
No
No
Cele\alh-5
2 of 14
No
No
Cele\alh-9
2 of 14
No
No
Cele\alh-10
2 of 14
No
No
Cele\alh-11
2 of 14
No
Yes
Cele\alh-12
2 of 14
No
Yes
Cele\alh-4
1 of 14
No
No
Cele\alh-6
1 of 14
No
No
Cele\alh-7
1 of 14
No
No
Cele\alh-8
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (10)
Agam\AgaP_AGAP003652
11 of 12
Yes
Yes
Agam\AgaP_AGAP003578
6 of 12
No
No
Agam\AgaP_AGAP009944
6 of 12
No
No
Agam\AgaP_AGAP009591
3 of 12
No
No
Agam\AgaP_AGAP000881
2 of 12
No
No
Agam\AgaP_AGAP002764
2 of 12
No
No
Agam\AgaP_AGAP003165
2 of 12
No
No
Agam\AgaP_AGAP004366
2 of 12
No
No
Agam\AgaP_AGAP005124
1 of 12
No
No
Agam\MMSA_ANOGA
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (14)
Atha\ALDH2B4
13 of 13
Yes
Yes
Atha\ALDH2B7
12 of 13
No
Yes
Atha\ALDH2C4
9 of 13
No
Yes
Atha\ALDH10A8
4 of 13
No
Yes
Atha\ALDH10A9
4 of 13
No
Yes
Atha\ALDH3F1
2 of 13
No
No
Atha\ALDH3H1
2 of 13
No
No
Atha\ALDH3I1
2 of 13
No
No
Atha\ALDH5F1
2 of 13
No
No
Atha\ALDH7B4
2 of 13
No
No
Atha\ALDH11A3
2 of 13
No
No
Atha\ALDH12A1
2 of 13
No
No
Atha\ALDH22A1
2 of 13
No
Yes
Atha\ALDH6B2
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (9)
Scer\ALD4
12 of 13
Yes
Yes
Scer\ALD5
12 of 13
Yes
Yes
Scer\ALD6
11 of 13
No
Yes
Scer\ALD2
6 of 13
No
No
Scer\ALD3
6 of 13
No
No
Scer\HFD1
2 of 13
No
No
Scer\MSC7
2 of 13
No
Yes
Scer\PUT2
2 of 13
No
No
Scer\UGA2
2 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (7)
Spom\SPAC9E9.09c
12 of 12
Yes
Yes
Spom\SPAC922.07c
7 of 12
No
Yes
Spom\meu8
4 of 12
No
Yes
Spom\SPAC139.05
2 of 12
No
No
Spom\SPAC1002.12c
2 of 12
No
No
Spom\SPBC21C3.15c
2 of 12
No
Yes
Spom\SPBC24C6.04
2 of 12
No
No
Escherichia coli (enterobacterium) (13)
Ecol\betB
7 of 11
Yes
Yes
Ecol\puuC
7 of 11
Yes
Yes
Ecol\aldB
5 of 11
No
Yes
Ecol\feaB
5 of 11
No
Yes
Ecol\aldA
3 of 11
No
Yes
Ecol\gabD
3 of 11
No
No
Ecol\astD
2 of 11
No
Yes
Ecol\eutE
2 of 11
No
Yes
Ecol\paaZ
2 of 11
No
Yes
Ecol\patD
2 of 11
No
Yes
Ecol\sad
2 of 11
No
Yes
Ecol\adhE
1 of 11
No
No
Ecol\putA
1 of 11
No
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Aldh. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (17)
CG31075
11 of 13
CG8665
8 of 13
Aldh7A1
3 of 13
Aldh-III
3 of 13
CG6661
3 of 13
P5CDh1
3 of 13
P5CDh2
3 of 13
Ssadh
3 of 13
CG11634
2 of 13
CG12516
2 of 13
CG15717
2 of 13
CG17896
2 of 13
CG2336
1 of 13
CG13539
1 of 13
CG31076
1 of 13
CG31274
1 of 13
MESK4
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    ALDH1A3; aldehyde dehydrogenase 1 family member A3
    model of  isolated microphthalmia 8
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    AldhRNAi.UAS.cUa
    ameliorates  high grade glioma
    modeled by PtenRNAi.UAS.cUa, Ras85DV12.UAS
    (Cheng et al., 2016)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ALDH2; aldehyde dehydrogenase 2 family member
    14 of 14
    100650
      ALDH1B1; aldehyde dehydrogenase 1 family member B1
      12 of 14
      100670
          ALDH1A1; aldehyde dehydrogenase 1 family member A1
          8 of 14
          100640
              ALDH1A2; aldehyde dehydrogenase 1 family member A2
              8 of 14
              603687
                ALDH1A3; aldehyde dehydrogenase 1 family member A3
                8 of 14
                600463
                ALDH1L1; aldehyde dehydrogenase 1 family member L1
                3 of 14
                600249
                     
                    ALDH1L2; aldehyde dehydrogenase 1 family member L2
                    3 of 14
                    613584
                        ALDH9A1; aldehyde dehydrogenase 9 family member A1
                        3 of 14
                        602733
                            Functional Complementation Data
                            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                            Interactions
                            Summary of Physical Interactions
                            Summary of Genetic Interactions
                            Interaction Browsers
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            Starting gene(s)
                            Interaction type
                            Interacting gene(s)
                            Reference
                            External Data
                            Linkouts
                            BioGRID - A database of protein and genetic interactions.
                            DroID - A comprehensive database of gene and protein interactions.
                            MIST (protein-protein) - An integrated Molecular Interaction Database
                            Pathways
                            Signaling Pathways (FlyBase)
                            Metabolic Pathways
                            External Data
                            Class of Gene
                            Genomic Location and Detailed Mapping Data
                            Chromosome (arm)
                            2L
                            Recombination map
                            2-35
                            Cytogenetic map
                            30B1-30B1
                            Sequence location
                            FlyBase Computed Cytological Location
                            Cytogenetic map
                            Evidence for location
                            30B1-30B1
                            Limits computationally determined from genome sequence between P{PZ}tai01351 and P{PZ}scat1&P{PZ}numb03235
                            Experimentally Determined Cytological Location
                            Cytogenetic map
                            Notes
                            References
                            Experimentally Determined Recombination Data
                            Location

                            2-35

                            (FlyBase, 2016)

                            2-30.2

                            (Comeron et al., 2012)
                            Left of (cM)
                            Right of (cM)
                            Notes
                            Stocks and Reagents
                            Stocks (10)
                            Genomic Clones (21)
                            cDNA Clones (232)
                             

                            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                            cDNA clones, fully sequenced
                            BDGP DGC clones
                            Other clones
                              Drosophila Genomics Resource Center cDNA clones

                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                              cDNA Clones, End Sequenced (ESTs)
                              BDGP DGC clones
                              Other clones
                              RNAi and Array Information
                              Linkouts
                              DRSC - Results frm RNAi screens
                              Antibody Information
                              Laboratory Generated Antibodies
                               
                              Commercially Available Antibodies
                               
                              Cell Line Information
                              Publicly Available Cell Lines
                               
                                Other Stable Cell Lines
                                 
                                  Other Comments

                                  Results are opposed to those of Lietaert, Experientia 38:651 and Lietaert, Experientia 41:57 , who concluded that the ALDH activity was mainly in the mitochondria.

                                  (Leal and Barbancho, 1993)

                                  Subcellular localization of the aldehyde dehydrogenase activity from the ALDH enzyme was studied in wild type and Adhn4 adults. Aldehyde dehydrogenase activities from Adh and Aldh gene products are selectively inhibited by cyanimide or acetone, respectively. Contrary to the situation in larvae, in adults the ALDH activity from the Aldh gene product is mainly in the cytosolic, as opposed to the mitochondrial, fraction. Although larvae and adults use different ALDH activities to detoxify acetaldehyde (from Adh and Aldh encoded enzymes, respectively) both activities are cytosolic.

                                  (Leal and Barbancho, 1993)

                                  In adults, as opposed to larvae, acetaldehyde is mainly oxidised into acetate by means of Aldh enzymes. The reducing activity of the Adh enzyme, which transforms acetaldehyde into ethanol, also plays an essential role in the detoxification of acetaldehyde.

                                  (Leal and Barbancho, 1992)

                                  The role of Adh, Aldh and Aldox-1 in alcohol/aldehyde metabolism in D.melanogaster has been studied.

                                  (Anderson and Barnett, 1991)

                                  The effect of variation of Adh and Aldh has on the flux from 14C-ethanol to lipids is examined in third-instar larvae.

                                  (Heinstra and Geer, 1991)

                                  Aldh gene product is present in larvae but the activity of this enzyme differs from the ALDH activity of the Adh gene product. Studies of the flux of ethanol into lipid suggested that more than 75% of the oxidation of acetaldehyde in wild type larvae is catalysed by Adh product.

                                  (Heinstra et al., 1989)
                                  Relationship to Other Genes
                                  Source for database merge of

                                  Source for merge of: Aldh CG3752

                                  (Fry et al., 2005)
                                  Additional comments
                                  Nomenclature History
                                  Source for database identify of
                                  Nomenclature comments
                                  Etymology
                                  Synonyms and Secondary IDs (15)
                                  Reported As
                                  Symbol Synonym
                                  146084_at
                                  (Kristensen et al., 2005)
                                  ACDH
                                  (Glassman et al., 1968)
                                  ALDH
                                  (Patel et al., 2017, Liu et al., 2009, Fry and Saweikis, 2006, Leal and Barbancho, 1992)
                                  ALDHA1
                                  (Wishart et al., 2012)
                                  Aldh
                                  (Floc'hlay et al., 2023, Khalili et al., 2023, National Institute of Genetics Fly Stocks, 2022-, Baker et al., 2021, Cattenoz et al., 2021, Gnainsky et al., 2021, Khan et al., 2021, Chen et al., 2020, Meltzer et al., 2019, Gene Disruption Project members, 2018-, Graham et al., 2017, Transgenic RNAi Project members, 2017-, Chakraborty and Fry, 2016, Clandinin and Owens, 2016-, Elgart et al., 2016, Narbonne-Reveau et al., 2016, Adrion et al., 2015, Dent et al., 2015, Shiao et al., 2015, Appocher et al., 2014, Chen et al., 2014, Luck et al., 2014, Martin et al., 2014, Sha et al., 2014, Stern et al., 2014, Wang et al., 2014, Kwon et al., 2013, Chen et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Stern et al., 2012, Yampolsky et al., 2012, Chakraborty and Fry, 2011, Friedman et al., 2011, O'Keefe et al., 2011, Gallach et al., 2010, Halme et al., 2010, Wasbrough et al., 2010, Tan et al., 2009, Fry et al., 2008, Ranade et al., 2008, Rothacker and Ilg, 2008, Beller et al., 2006, Cermelli et al., 2006, Montooth et al., 2006)
                                  CG 3752
                                  (Alonso et al., 2005)
                                  CG3752
                                  (National Institute of Genetics Fly Stocks, 2022-, Carillo et al., 2020, Kolkhof et al., 2017, Çiçek et al., 2016, Wu et al., 2016, Rosa-Ferreira et al., 2015, Ibrahim et al., 2013, Walls et al., 2013, Cammarato et al., 2011, Ni et al., 2011.7.19, O'Keefe et al., 2011, Mosallanejad et al., 2010, Liu et al., 2009, Haussmann et al., 2008, Rothacker and Ilg, 2008, Cermelli et al., 2006, Dorus et al., 2006, Fry et al., 2005)
                                  DmALDH
                                  (Cheng et al., 2016)
                                  Q9VLC5
                                  (Ebanks et al., 2021)
                                  TMABADH
                                  (Carillo et al., 2020)
                                  Name Synonyms
                                  Acetaldehyde dehydrogenase
                                  (Cermelli et al., 2006, Seegmiller et al., 2002, Heinstra et al., 1989)
                                  Aldehyde dehydrogenase
                                  (Garlovsky et al., 2022, Ebanks et al., 2021, Chakraborty and Fry, 2016, Narbonne-Reveau et al., 2016, Wang et al., 2014, Ibrahim et al., 2013, Cammarato et al., 2011, Gonsalves et al., 2011, Halme et al., 2010, Robinson et al., 2010, Liu et al., 2009, Fry and Saweikis, 2006, Leal and Barbancho, 1993, Anderson and Barnett, 1991)
                                  acetaldehyde dehydrogenase
                                  (Montooth et al., 2006)
                                  aldehyde dehydrogenase
                                  (Stern et al., 2012, O'Keefe et al., 2011, Culwell et al., 2008)
                                  γ-TriMethylAminoButyrAldehyde DeHydrogenase
                                  (Carillo et al., 2020)
                                  Secondary FlyBase IDs
                                  • FBgn0032114
                                  Datasets (0)
                                  Study focus (0)
                                  Experimental Role
                                  Project
                                  Project Type
                                  Title
                                  Study result (0)
                                  Result
                                  Result Type
                                  Title
                                  External Crossreferences and Linkouts ( 91 )
                                  Sequence Crossreferences
                                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                  UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                  Other crossreferences
                                  AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                  DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                  EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                  FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                  FlyMine - An integrated database for Drosophila genomics
                                  InterPro - A database of protein families, domains and functional sites
                                  KEGG Genes - Molecular building blocks of life in the genomic space.
                                  MARRVEL_MODEL - MARRVEL (model organism gene)
                                  Linkouts
                                  BioGRID - A database of protein and genetic interactions.
                                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                  DroID - A comprehensive database of gene and protein interactions.
                                  DRSC - Results frm RNAi screens
                                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                  FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                  Flygut - An atlas of the Drosophila adult midgut
                                  FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                  KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                  KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
                                  MIST (protein-protein) - An integrated Molecular Interaction Database
                                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                  Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                  References (127)