FB2021_03, released June 15, 2021

Gene: Dmel\Aldh

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General Information
Symbol
Dmel\Aldh
Species
D. melanogaster
Name
Aldehyde dehydrogenase
Annotation Symbol
CG3752
Feature Type
protein_coding_gene
FlyBase ID
FBgn0012036
Gene Model Status
Current
Stock Availability
7 publicly available
Enzyme Name (EC)
Acetaldehyde dehydrogenase (acetylating) (1.2.1.10)
Aldehyde dehydrogenase (NAD(+)) (1.2.1.3)
Gene Summary
Aldehyde dehydrogenase (Aldh) encodes an NAD[+] dependent mitochondrial aldehyde dehydrogenase. Its functions include detoxifying endogenous aldehydes generated by lipid peroxidation, and detoxifying acetaldehyde derived from dietary ethanol. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Acetaldehyde dehydrogenase

Key Links
Genomic Location
Cytogenetic map
30B1-30B1
Sequence location
2L:9,387,389..9,391,567 [+]
Recombination map
2-35
RefSeq locus
NT_033779 REGION:9387389..9391567
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables acetaldehyde dehydrogenase (acetylating) activity
inferred from direct assay
(Leal and Barbancho, 1992)
inferred from mutant phenotype
(Chakraborty and Fry, 2016)
enables aldehyde dehydrogenase (NAD+) activity
inferred from direct assay
(Rothacker and Ilg, 2008, Leal and Barbancho, 1993)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables aldehyde dehydrogenase (NAD+) activity
inferred from biological aspect of ancestor with PANTHER:PTN000192421
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in acetaldehyde metabolic process
inferred from mutant phenotype
(Leal and Barbancho, 1992)
involved_in negative regulation of neuron death
inferred from mutant phenotype
(Wishart et al., 2012)
involved_in response to ethanol
inferred from mutant phenotype
(Fry and Saweikis, 2006)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Leal and Barbancho, 1993)
located_in mitochondrion
inferred from high throughput direct assay
(Tan et al., 2009, Alonso et al., 2005)
inferred from direct assay
(Leal and Barbancho, 1993)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
Acetaldehyde + CoA + NAD(+) = acetyl-CoA + NADH (1.2.1.10)
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH (1.2.1.3)
Predictions / Assertions
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH (1.2.1.3)
Summaries
Gene Snapshot
Aldehyde dehydrogenase (Aldh) encodes an NAD[+] dependent mitochondrial aldehyde dehydrogenase. Its functions include detoxifying endogenous aldehydes generated by lipid peroxidation, and detoxifying acetaldehyde derived from dietary ethanol. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
OTHER ALDEHYDE OR OXO OXIDOREDUCTASES, NAD OR NADP AS ACCEPTOR -
Enzymes within listed within 'Other aldehyde or oxo oxidoreductases, NAD or NADP as acceptor' do not fit into any of the other major groups.
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Aldh for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Aldh-RA
FBtr0079806
NM_135441
2070
520
Aldh-RB
FBtr0332597
NM_001273361
1900
520
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Aldh-PA
FBpp0079406
57.0
520
6.79
NP_609285
AAF52769
Aldh-PB
FBpp0304847
57.0
520
6.79
NP_001260290
AGB92825
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

520 aa isoforms: Aldh-PA, Aldh-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Aldh using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010, Dorus et al., 2006)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data

Acetaldeyhde dehyrogenase activity from the Aldh gene is mainly cytosolic in adults though some is located in the mitochondria.

(Leal and Barbancho, 1993)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Leal and Barbancho, 1993)
located_in mitochondrion
inferred from high throughput direct assay
(Tan et al., 2009, Alonso et al., 2005)
inferred from direct assay
(Leal and Barbancho, 1993)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Aldh in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 11 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Aldh
Transgenic constructs containing regulatory region of Aldh
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)N22-14
(Fry and Saweikis, 2006)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ALDH2
15 of 15
Yes
Yes
Hsap\ALDH1B1
9 of 15
No
Yes
Hsap\ALDH1A1
6 of 15
No
No
Hsap\ALDH1A2
5 of 15
No
No
Hsap\ALDH1A3
5 of 15
No
No
Hsap\ALDH1L1
2 of 15
No
No
2  
Hsap\ALDH1L2
2 of 15
No
No
Hsap\ALDH9A1
2 of 15
No
No
Hsap\ALDH3A1
1 of 15
No
No
1  
Hsap\ALDH3A2
1 of 15
No
No
1  
Hsap\ALDH3B1
1 of 15
No
No
Hsap\ALDH3B2
1 of 15
No
No
1  
Hsap\ALDH4A1
1 of 15
No
No
Hsap\ALDH5A1
1 of 15
No
No
Hsap\ALDH7A1
1 of 15
No
No
Hsap\ALDH8A1
1 of 15
No
No
Hsap\ALDH16A1
1 of 15
No
No
Hsap\HGF
1 of 15
No
No
1  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Aldh2
15 of 15
Yes
Yes
Mmus\Aldh1b1
9 of 15
No
Yes
Mmus\Aldh1a1
6 of 15
No
Yes
Mmus\Aldh1a2
5 of 15
No
No
Mmus\Aldh1a3
5 of 15
No
No
Mmus\Aldh1a7
5 of 15
No
No
Mmus\Aldh1l1
2 of 15
No
No
Mmus\Aldh1l2
2 of 15
No
No
Mmus\Aldh9a1
2 of 15
No
Yes
Mmus\Aldh3a1
1 of 15
No
No
Mmus\Aldh3a2
1 of 15
No
No
Mmus\Aldh3b1
1 of 15
No
No
Mmus\Aldh3b2
1 of 15
No
No
Mmus\Aldh3b3
1 of 15
No
No
Mmus\Aldh4a1
1 of 15
No
No
Mmus\Aldh5a1
1 of 15
No
No
Mmus\Aldh7a1
1 of 15
No
No
Mmus\Aldh8a1
1 of 15
No
Yes
Mmus\Aldh16a1
1 of 15
No
No
Rattus norvegicus (Norway rat) (16)
Rnor\Aldh2
13 of 13
Yes
Yes
Rnor\Aldh1b1
10 of 13
No
Yes
Rnor\Aldh1a1
4 of 13
No
No
Rnor\Aldh1a2
3 of 13
No
No
Rnor\Aldh1a3
3 of 13
No
No
Rnor\Aldh1a7
3 of 13
No
Yes
Rnor\Aldh1l1
2 of 13
No
No
Rnor\Aldh1l2
2 of 13
No
No
Rnor\Aldh9a1
2 of 13
No
Yes
Rnor\Aldh3a1
1 of 13
No
No
Rnor\Aldh3a2
1 of 13
No
No
Rnor\Aldh3b1
1 of 13
No
No
Rnor\Aldh5a1
1 of 13
No
No
Rnor\Aldh7a1
1 of 13
No
No
Rnor\Aldh8a1
1 of 13
No
No
Rnor\Aldh16a1
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (16)
Xtro\aldh2
8 of 12
Yes
Yes
Xtro\aldh1b1
7 of 12
No
Yes
Xtro\aldh1a1
4 of 12
No
No
Xtro\aldh1a2
4 of 12
No
No
Xtro\aldh1a3
4 of 12
No
No
Xtro\aldh1l1
2 of 12
No
No
Xtro\aldh1l2
2 of 12
No
No
Xtro\aldh9a1
2 of 12
No
Yes
Xtro\aldh3a2
1 of 12
No
No
Xtro\aldh3b1
1 of 12
No
No
Xtro\aldh3b2
1 of 12
No
No
Xtro\aldh4a1
1 of 12
No
No
Xtro\aldh5a1
1 of 12
No
No
Xtro\aldh7a1
1 of 12
No
No
Xtro\aldh8a1
1 of 12
No
No
Xtro\aldh16a1
1 of 12
No
Yes
Danio rerio (Zebrafish) (20)
Drer\aldh2.1
10 of 15
Yes
Yes
Drer\aldh2.2
8 of 15
No
Yes
Drer\aldh1a2
5 of 15
No
No
Drer\wu:fb14d09
5 of 15
No
Yes
Drer\aldh1a3
4 of 15
No
Yes
Drer\aldh1l1
2 of 15
No
No
Drer\aldh1l2
2 of 15
No
No
Drer\aldh9a1a.1
2 of 15
No
No
Drer\aldh9a1b
2 of 15
No
No
Drer\aldh3a1
1 of 15
No
No
Drer\aldh3a2a
1 of 15
No
No
Drer\aldh3a2b
1 of 15
No
No
Drer\aldh3b1
1 of 15
No
No
Drer\aldh3b2
1 of 15
No
No
Drer\aldh4a1
1 of 15
No
No
Drer\aldh5a1
1 of 15
No
No
Drer\aldh7a1
1 of 15
No
No
Drer\aldh8a1
1 of 15
No
No
Drer\aldh9a1a.2
1 of 15
No
No
Drer\aldh16a1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\alh-1
13 of 15
Yes
Yes
Cele\alh-2
13 of 15
Yes
Yes
Cele\alh-3
2 of 15
No
No
Cele\alh-11
2 of 15
No
Yes
Cele\alh-5
1 of 15
No
No
Cele\alh-10
1 of 15
No
No
Cele\alh-12
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (6)
Atha\ALDH2B4
9 of 9
Yes
Yes
Atha\ALDH2B7
8 of 9
No
Yes
Atha\ALDH2C4
5 of 9
No
No
Atha\ALDH10A8
1 of 9
No
Yes
Atha\ALDH10A9
1 of 9
No
Yes
Atha\ALDH11A3
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (9)
Scer\ALD4
12 of 15
Yes
Yes
Scer\ALD5
12 of 15
Yes
Yes
Scer\ALD6
7 of 15
No
Yes
Scer\ALD2
6 of 15
No
Yes
Scer\ALD3
6 of 15
No
Yes
Scer\MSC7
2 of 15
No
Yes
Scer\HFD1
1 of 15
No
No
Scer\PUT2
1 of 15
No
No
Scer\UGA2
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\SPAC9E9.09c
10 of 12
Yes
Yes
Spom\SPAC922.07c
5 of 12
No
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905MO )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001575
Drosophila simulans
Dsim\GD23600
Drosophila sechellia
Dsec\GM17439
Drosophila erecta
Dere\GG25345
Drosophila yakuba
Dyak\GE18837
Drosophila ananassae
Dana\GF22728
Drosophila pseudoobscura pseudoobscura
Dpse\GA17661
Drosophila persimilis
Dper\GL26145
Drosophila willistoni
Dwil\GK24201
Drosophila virilis
Dvir\GJ17859
Drosophila mojavensis
Dmoj\GI17663
Drosophila grimshawi
Dgri\GH13324
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091503EL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17025865
Musca domestica
House fly
Mdoa\17008574
Musca domestica
House fly
Mdoa\17004601
Glossina morsitans
Tsetse fly
Gmor\GMOY003209
Glossina morsitans
Tsetse fly
Gmor\GMOY002513
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00444
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04514
Mayetiola destructor
Hessian fly
Mdes\Mdes001980
Aedes aegypti
Yellow fever mosquito
Aaeg\ALDH9029
Aedes aegypti
Yellow fever mosquito
Aaeg\ALDH9948
Aedes aegypti
Yellow fever mosquito
Aaeg\ALDH14080
Anopheles darlingi
American malaria mosquito
Adar\ADAC004842
Anopheles darlingi
American malaria mosquito
Adar\ADAC002161
Anopheles darlingi
American malaria mosquito
Adar\ADAC010056
Anopheles gambiae
Malaria mosquito
Agam\AGAP003578
Anopheles gambiae
Malaria mosquito
Agam\AGAP009944
Anopheles gambiae
Malaria mosquito
Agam\AGAP003652
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ014581
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003432
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ007198
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W036H )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002457
Bombyx mori
Silkmoth
Bmor\BGIBMGA010403
Bombyx mori
Silkmoth
Bmor\BGIBMGA001402
Danaus plexippus
Monarch butterfly
Dple\DPOGS201995-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS201994-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS205397-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS208887-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL007157
Heliconius melpomene
Postman butterfly
Hmel\HMEL002628
Apis florea
Little honeybee
Aflo\2168832084
Apis florea
Little honeybee
Aflo\2434933236
Apis mellifera
Western honey bee
Amel\GB51283
Apis mellifera
Western honey bee
Amel\GB49240
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20575
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24408
Bombus terrestris
Buff-tailed bumblebee
Bter\15206249
Bombus terrestris
Buff-tailed bumblebee
Bter\15203081
Linepithema humile
Argentine ant
Lhum\LH17105
Linepithema humile
Argentine ant
Lhum\LH11078
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00149f
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00063a
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011047
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013575
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG011046
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06979
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10930
Tribolium castaneum
Red flour beetle
Tcas\TC011192
Tribolium castaneum
Red flour beetle
Tcas\TC000960
Pediculus humanus
Human body louse
Phum\PHUM307790
Pediculus humanus
Human body louse
Phum\PHUM222120
Rhodnius prolixus
Kissing bug
Rpro\RPRC003924
Rhodnius prolixus
Kissing bug
Rpro\RPRC003945
Rhodnius prolixus
Kissing bug
Rpro\RPRC003294
Cimex lectularius
Bed bug
Clec\CLEC002164
Cimex lectularius
Bed bug
Clec\CLEC002163
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003925
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009744
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_00567
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11194
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11195
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X033B )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011487
Strigamia maritima
European centipede
Smar\SMAR012009
Ixodes scapularis
Black-legged tick
Isca\ISCW023288
Ixodes scapularis
Black-legged tick
Isca\ISCW014613
Ixodes scapularis
Black-legged tick
Isca\ISCW012082
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63313.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71913.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM66788.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78573.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur27g01550
Tetranychus urticae
Two-spotted spider mite
Turt\tetur28g02490
Tetranychus urticae
Two-spotted spider mite
Turt\tetur28g02510
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_215225
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_51170
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_305826
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05E8 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aldh9aLf
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aldh1l1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aldh8a1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aldh2_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aldh9a1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aldh2_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aldh1l1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aldh2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Aldh8a1
Ciona intestinalis
Vase tunicate
Cint\LOC100187192
Ciona intestinalis
Vase tunicate
Cint\LOC100184767
Ciona intestinalis
Vase tunicate
Cint\LOC100175707
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007939
Ciona intestinalis
Vase tunicate
Cint\LOC100177969
Ciona intestinalis
Vase tunicate
Cint\LOC100176963
Ciona intestinalis
Vase tunicate
Cint\LOC100183764
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027896
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000003495
Gallus gallus
Domestic chicken
Ggal\ALDH1A1
Gallus gallus
Domestic chicken
Ggal\ALDH1A2
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000013969
Gallus gallus
Domestic chicken
Ggal\ALDH1L2
Gallus gallus
Domestic chicken
Ggal\ALDH2
Gallus gallus
Domestic chicken
Ggal\ALDH6
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (17)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG31075
9 of 10
CG8665
4 of 10
Aldh7A1
2 of 10
Aldh-III
2 of 10
CG6661
2 of 10
P5CDh1
2 of 10
P5CDh2
2 of 10
Ssadh
2 of 10
CG2336
1 of 10
CG11634
1 of 10
CG12516
1 of 10
CG15717
1 of 10
CG17896
1 of 10
CG31076
1 of 10
CG31274
1 of 10
CG31465
1 of 10
MESK4
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ALDH2; aldehyde dehydrogenase 2 family member
    15 of 15
    100650
      ALDH1B1; aldehyde dehydrogenase 1 family member B1
      9 of 15
      100670
          ALDH1A1; aldehyde dehydrogenase 1 family member A1
          6 of 15
          100640
              ALDH1A2; aldehyde dehydrogenase 1 family member A2
              5 of 15
              603687
                  ALDH1A3; aldehyde dehydrogenase 1 family member A3
                  5 of 15
                  600463
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  Summary of Genetic Interactions
                  esyN Network Diagram
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  External Data
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Pathways
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  2L
                  Recombination map
                  2-35
                  Cytogenetic map
                  30B1-30B1
                  Sequence location
                  2L:9,387,389..9,391,567 [+]
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  30B1-30B1
                  Limits computationally determined from genome sequence between P{PZ}tai01351 and P{PZ}scat1&P{PZ}numb03235
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  Experimentally Determined Recombination Data
                  Location

                  2-35

                  (FlyBase, 2016)

                  2-30.2

                  (Comeron et al., 2012)
                  Left of (cM)
                  Right of (cM)
                  Notes
                  Stocks and Reagents
                  Stocks (7)
                  Genomic Clones (21)
                  cDNA Clones (237)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequenced
                  BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  Antibody Information
                  Laboratory Generated Antibodies
                   
                  Commercially Available Antibodies
                   
                  Other Information
                  Relationship to Other Genes
                  Source for database identify of
                  Source for database merge of

                  Source for merge of: Aldh CG3752

                  (Fry et al., 2005)
                  Additional comments
                  Other Comments

                  Results are opposed to those of Lietaert, Experientia 38:651 and Lietaert, Experientia 41:57 , who concluded that the ALDH activity was mainly in the mitochondria.

                  (Leal and Barbancho, 1993)

                  Subcellular localization of the aldehyde dehydrogenase activity from the ALDH enzyme was studied in wild type and Adhn4 adults. Aldehyde dehydrogenase activities from Adh and Aldh gene products are selectively inhibited by cyanimide or acetone, respectively. Contrary to the situation in larvae, in adults the ALDH activity from the Aldh gene product is mainly in the cytosolic, as opposed to the mitochondrial, fraction. Although larvae and adults use different ALDH activities to detoxify acetaldehyde (from Adh and Aldh encoded enzymes, respectively) both activities are cytosolic.

                  (Leal and Barbancho, 1993)

                  In adults, as opposed to larvae, acetaldehyde is mainly oxidised into acetate by means of Aldh enzymes. The reducing activity of the Adh enzyme, which transforms acetaldehyde into ethanol, also plays an essential role in the detoxification of acetaldehyde.

                  (Leal and Barbancho, 1992)

                  The role of Adh, Aldh and Aldox-1 in alcohol/aldehyde metabolism in D.melanogaster has been studied.

                  (Anderson and Barnett, 1991)

                  The effect of variation of Adh and Aldh has on the flux from 14C-ethanol to lipids is examined in third-instar larvae.

                  (Heinstra and Geer, 1991)

                  Aldh gene product is present in larvae but the activity of this enzyme differs from the ALDH activity of the Adh gene product. Studies of the flux of ethanol into lipid suggested that more than 75% of the oxidation of acetaldehyde in wild type larvae is catalysed by Adh product.

                  (Heinstra et al., 1989)
                  Origin and Etymology
                  Discoverer
                  Etymology
                  Identification
                  External Crossreferences and Linkouts ( 63 )
                  Sequence Crossreferences
                  NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                  GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                  GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                  RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                  UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                  Other crossreferences
                  BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                  Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                  DRscDB
                  EMBL-EBI Single Cell Expression Atlas
                  Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                  Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                  Flygut - An atlas of the Drosophila adult midgut
                  GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                  iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                  InterPro - A database of protein families, domains and functional sites
                  KEGG Genes - Molecular building blocks of life in the genomic space.
                  MARRVEL_MODEL
                  modMine - A data warehouse for the modENCODE project
                  Linkouts
                  BioGRID - A database of protein and genetic interactions.
                  DroID - A comprehensive database of gene and protein interactions.
                  DRSC - Results frm RNAi screens
                  FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                  FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                  FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                  FlyMine - An integrated database for Drosophila genomics
                  InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                  KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Synonyms and Secondary IDs (14)
                  Reported As
                  Symbol Synonym
                  146084_at
                  (Kristensen et al., 2005)
                  ACDH
                  (Glassman et al., 1968)
                  ALDH
                  (Patel et al., 2017, Liu et al., 2009, Fry and Saweikis, 2006, Leal and Barbancho, 1992)
                  ALDHA1
                  (Wishart et al., 2012)
                  Aldh
                  (Cattenoz et al., 2021, Gnainsky et al., 2021, Chen et al., 2020, Meltzer et al., 2019, Gene Disruption Project members, 2018-, Graham et al., 2017, Transgenic RNAi Project members, 2017-, Chakraborty and Fry, 2016, Clandinin and Owens, 2016-, Elgart et al., 2016, Narbonne-Reveau et al., 2016, Adrion et al., 2015, Dent et al., 2015, Shiao et al., 2015, Appocher et al., 2014, Chen et al., 2014, Luck et al., 2014, Martin et al., 2014, Sha et al., 2014, Stern et al., 2014, Wang et al., 2014, Kwon et al., 2013, Chen et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Stern et al., 2012, Yampolsky et al., 2012, Chakraborty and Fry, 2011, Friedman et al., 2011, O'Keefe et al., 2011, Gallach et al., 2010, Halme et al., 2010, Wasbrough et al., 2010, Tan et al., 2009, Fry et al., 2008, Ranade et al., 2008, Rothacker and Ilg, 2008, Beller et al., 2006, Cermelli et al., 2006, Montooth et al., 2006)
                  CG 3752
                  (Alonso et al., 2005)
                  CG3752
                  (Carillo et al., 2020, Kolkhof et al., 2017, Çiçek et al., 2016, Wu et al., 2016, Rosa-Ferreira et al., 2015, Ibrahim et al., 2013, Walls et al., 2013, Cammarato et al., 2011, Ni et al., 2011.7.19, O'Keefe et al., 2011, Mosallanejad et al., 2010, Liu et al., 2009, Haussmann et al., 2008, Rothacker and Ilg, 2008, Cermelli et al., 2006, Dorus et al., 2006, Fry et al., 2005)
                  DmALDH
                  (Cheng et al., 2016)
                  TMABADH
                  (Carillo et al., 2020)
                  Name Synonyms
                  Acetaldehyde dehydrogenase
                  (Cermelli et al., 2006, Seegmiller et al., 2002, Heinstra et al., 1989)
                  Aldehyde dehydrogenase
                  (Chakraborty and Fry, 2016, Narbonne-Reveau et al., 2016, Wang et al., 2014, Ibrahim et al., 2013, Cammarato et al., 2011, Gonsalves et al., 2011, Halme et al., 2010, Robinson et al., 2010, Liu et al., 2009, Fry and Saweikis, 2006, Leal and Barbancho, 1993, Anderson and Barnett, 1991)
                  acetaldehyde dehydrogenase
                  (Montooth et al., 2006)
                  aldehyde dehydrogenase
                  (Stern et al., 2012, O'Keefe et al., 2011, Culwell et al., 2008)
                  γ-TriMethylAminoButyrAldehyde DeHydrogenase
                  (Carillo et al., 2020)
                  Secondary FlyBase IDs
                  • FBgn0032114
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (113)