Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Aldh using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Aldh in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Aldh CG3752
Results are opposed to those of Lietaert, Experientia 38:651 and Lietaert, Experientia 41:57 , who concluded that the ALDH activity was mainly in the mitochondria.
Subcellular localization of the aldehyde dehydrogenase activity from the ALDH enzyme was studied in wild type and Adhn4 adults. Aldehyde dehydrogenase activities from Adh and Aldh gene products are selectively inhibited by cyanimide or acetone, respectively. Contrary to the situation in larvae, in adults the ALDH activity from the Aldh gene product is mainly in the cytosolic, as opposed to the mitochondrial, fraction. Although larvae and adults use different ALDH activities to detoxify acetaldehyde (from Adh and Aldh encoded enzymes, respectively) both activities are cytosolic.
In adults, as opposed to larvae, acetaldehyde is mainly oxidised into acetate by means of Aldh enzymes. The reducing activity of the Adh enzyme, which transforms acetaldehyde into ethanol, also plays an essential role in the detoxification of acetaldehyde.
Aldh gene product is present in larvae but the activity of this enzyme differs from the ALDH activity of the Adh gene product. Studies of the flux of ethanol into lipid suggested that more than 75% of the oxidation of acetaldehyde in wild type larvae is catalysed by Adh product.