• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Ance

General Information
Symbol	Dmel\Ance	Species	D. melanogaster
Name	Angiotensin converting enzyme	Annotation symbol	CG8827
Feature type	protein_coding_gene	FlyBase ID	FBgn0012037
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	Race, l(2)34Eb, ACE, BG:DS08220.3, l(2)br31
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	34E2-34E2	Sequence location	2L:13,905,645..13,909,172 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Angiotensin converting enzyme is referred to in FlyBase by the symbol Dmel\Ance (CG8827, FBgn0012037). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: peptidyl-dipeptidase activity. There is experimental evidence that it is involved in the biological process: spermatid nucleus differentiation; sperm individualization; metamorphosis; response to symbiotic bacterium. 6 alleles are reported. The phenotypes of these alleles are annotated with: major mitochondrial derivative; spermatid; testis; primary spermatocyte cyst; minor mitochondrial derivative. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Peptidase M2, peptidyl-dipeptidase A. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut, larval fat body, adult salivary gland, larval trachea, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult hindgut, larval Malpighian tubules, adult heart, adult fat body, adult spermathecae, adult male reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632431_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Ance. Gene sequence location is 2L:13905645..13909172.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(2)34Eb Heteroallelic combinations escape about 10% with thin bristles; female fertile; male sterile.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Gurunathan et al., 2004, BMC Bioinformatics 5: 202
FB2012_01	References Akif et al., 2010, J. Mol. Biol. 400(3): 502--517 Akif et al., 2010, Biochem. Biophys. Res. Commun. 398(3): 532--536 Sequence features BKN22567 HFA01865 BKN46346
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 34E2-34E2   Limits computationally determined from genome sequence between P{lacW}Sosk05224&P{lacW}RpII33k05605 and P{lacW}l(2)34Fak00811&P{PZ}wb09437
Experimentally Determined Cytological Location
Cytogenetic map Notes References 34E-34E   (determined by in situ hybridisation)   (Tatei et al., 1995) 34A-34A   (determined by in situ hybridisation)   (Cornell et al., 1995)
Experimentally Determined Recombination Data
Location	2-
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ance for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ance-RA FBtr0080552  NM_057698   2006   615 Ance-RB FBtr0080553  NM_165070   1991   615
Additional Transcript Data & Comments
Reported size (kB)	4.0, 2.0 (northern blot) (Tatei et al., 1995) 2.1 (northern blot) (Cornell et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ance-PA   FBpp0080129   70.9   615   4.78     NP_477046   AAF53353 Ance-PB   FBpp0080130   70.9   615   4.78     NP_723852   AAN10856
Additional Polypeptide Data & Comments
Reported size (kDa)	615 (aa); 67 (kD observed) (Cornell et al., 1995) 615 (aa) (Tatei et al., 1995)
Comments	Ance protein was purified from Drosophila embryos. Ance protein, expressed in COS cells, is a secreted enzyme,which converts angiotensin I to angiotensin II and is inhibited by captopril and trandolaprilat. (Cornell et al., 1995)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M2, peptidyl-dipeptidase A (IPR001548) MEROPS - An information resource for peptidases and the proteins that inhibit them • M02.003
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246993   AA392405   AA433287   AA536582   AA694939   AA695131   AE014134 AAF53353   AE014134 AAN10856   AC092223   AE003408 AAF44834   AI108085   AI260382   AI260736   AI260812   AI295251   AI295406   AI295438   AI295999   AI387659   AI404742   AI405496   AI515154   AI519344   AW942183   AY061129 AAL28677   BF488497   BF489057   BF489635   BF502630   BF506693   BG633956   BI170125   BI173144   BI173350   BI212702   BI212810   BI228882   BI229155   BI233074   BI235517   BI240362   BI362006   BI362012   BI363537   BI363612   BI371531   BI373791   BI482531   BI578925   BI579051   BI588377   BI612523   BI627190   BI630773   CK658914   CK660538   CK660660   CO181178   CO185695   CO194868   CO268474   CO268498   CO282172   CO288629   CO301195   CO305734   CO306548   CO306725   CO307504   CO309171   CO323752   EC051637   EC052638   EC054117   EC055952   EC057105   EC066170   EC203152   EC203451   EC208548   EC212024   EC213092   EC214922   EC222438   EC226686   EC231702   EC237845   EC242063   EC248157   EC249448   EL871543   EL871772   EL871905   EL878953   EL878954   EL879092   EL879093   ES691445   ES691468   EV588189   EV590307   FF579072   GH749320   GH750474   GH752660   GH753109   GH753179   GH753264   GH753809   GH755273   GH756498   GH756645   GH757256   GH757757   GH758452   GH760612   GH760636   GH771711   GH772403   GH772445   GH773003   GH773031   GH774109   GH774195   GH775484   GH775995   GH777173   GH777466   GH778481   GH778565   GH778581   GH780422   GH781782   GH782524   GH782719   GH783026   GH784695   GH785096   GH786548   GH786872   GH786879   GH788291   GH790862   GH793214   GH793542   GH794463   GH794793   GH795047   GH795516   GH796120   GH796214   GH798329   GH798846   GH798900   GH799633   GH800117   GH801064   GH803708   GH803740   GH803827   GH805399   GH807246   GH813370   GH814529   GH815652   GH815975   GH816137   GH816854   GH817081   GH818161   GH818253   GH818271   GH819132   GH820228   GH821241   GH821390   GH821391   GH823554   GH823862   GH824298   GH824619   GH824627   GH826722   GH827750   GH827934   GH828132   GH828407   GH828568   GH829219   GH829403   GH831757   GH832147   GH834949   GH835239   GH837833   GH838428   GH838537   GH840139   GH841950   GH842370   GH842433   GH843959   GH844604   GH844627   GH846133   GH846752   GH847044   GH847356   GH847619   GH847707   GH848564   GH848645   GH849268   GH850923   GH854690   GH855151   GH855365   GH858797   GH859985   GH860565   GH861029   GH862253   GH862695   GH862855   GH862980   GH863339   GH863646   GH864277   GH864561   GH864611   GH866304   GH866915   GH867459   GH867740   GH867997   GH868715   GH868875   GH869278   GH869368   GH869935   GH870102   GH870154   GH871546   GH871621   GH872236   GH873313   GH874811   GH874966   GH875068   GH875249   GH875380   GH875473   GH876652   GH876664   GH877031   GH877231   GH878563   GH880057   GH880739   GH881515   GH884273   GH886523   GH886940   GH887809   GH887891   GH889664   GH889762   GH889945   GH890001   GH891411   GH892183   GH893191   GH893341   GH893345   GH893591   GH896053   GH896382   GH896499   GH896645   GH896862   GH897364   GH897664   GH898340   GH898524   GH898653   GH899546   GH900467   GH900896   GH901445   GH902041   GH902230   GH902768   GH903080   GH903879   GH904647   GH905063   GH905648   GH907505   GH909176   GH909432   GH911235   GH911497   GH911599   GH912392   GH912564   GH915323   GH915739   GH916108   GH916384   GH916987   GH917460   GH917766   GH918911   GH919887   GH920196   GH920384   GH921420   GH921509   GH922101   GH922345   GH923309   GH923399   GH923516   GH923562   GH924375   GH927330   GH928253   GH928628   GH930947   GH931294   GH931385   GH931726   GH933338   GH933768   GH933835   GH933994   GH934744   GH935363   GH935600   GH935821   GH936707   GH937148   GH937374   GH938161   GH939183   GH939359   GH939576   GH940081   GH940437   GH940764   L80114   U25344 AAB02171   U34599 AAC46902
UniProtKB/Swiss-Prot	Q10714
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000159861 2L:13,905,145..13,905,161 bound_moiety=zen-XP evidence=experimental (Rusch and Levine, 1997, Bergman et al., 2004) protein binding site FBsf0000159740 2L:13,905,234..13,905,259 bound_moiety=zen-XP evidence=experimental (Bergman et al., 2004, Rusch and Levine, 1997) protein binding site FBsf0000159977 2L:13,905,030..13,905,048 bound_moiety=zen-XP evidence=experimental (Rusch and Levine, 1997) regulatory region FBsf0000161325 2L:13,904,733..13,905,265 comment=The Ance enhancer element directs lacZ reporter expression in an endogenous pattern. The element was mapped to a ClaI-XhoI restriction fragment; position of restriction fragment on reference sequence inferred by FlyBase curator evidence=experimental linked_to=ClaI-XhoI_rfrag (Tatei et al., 1995)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 15   lateral head epidermis | dorsal   (Chang et al., 2001) Comment:dorsolateral stripe in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5   amnioserosa anlage in statu nascendi   (Rusch and Levine, 1997) embryonic stage 6   amnioserosa anlage   (Wharton et al., 2004) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   pericardial cell   (Tatei et al., 1995) embryonic/larval dorsal vessel   (Tatei et al., 1995) embryonic stage -- adult stage     (Tatei et al., 1995) embryonic stage 5 -- 13   amnioserosa   (Tatei et al., 1995) embryonic stage 9 -- 15     (Tatei et al., 1995) Comment:reference states 4-12 hr AEL embryonic stage 10 -- 17   anterior embryonic/larval midgut   (Tatei et al., 1995) posterior embryonic/larval midgut   (Tatei et al., 1995)
Additional Descriptive Data
	The major 2kb Ance transcript is expressed throughout development but is not present in ovaries. Ance transcripts are detected in embryos by in situ hybridization in the amnioserosa from 1.5 hrs through germ band shortening. Expression is detected in the anterior and posterior midguts in germ band elongated and retracting embryos. In later embryos, expression appears in pericardial cells associated with the dorsal vessel. In zen and dpp mutants, there is a complete absence of staining in the amnioserosa but midgut expression is normal. (Tatei et al., 1995)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0012037    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0012037 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0012037 expression level Developmental Stage   Expression Level embryo 00-02hr    296 embryo 02-04hr    2980 embryo 04-06hr    11671 embryo 06-08hr    21044 embryo 08-10hr    21484 embryo 10-12hr    24126 embryo 12-14hr    14474 embryo 14-16hr    10903 embryo 16-18hr    6631 embryo 18-20hr    7333 embryo 20-22hr    9156 embryo 22-24hr    10039 larva L1    8474 larva L2    13775 larva L3 12hr old    8878 larva L3 puffstage 1-2    13927 larva L3 puffstage 3-6    14755 larva L3 puffstage 7-9    20115 white prepupae new    19845 white prepupae 12hr    7736 white prepupae 24hr    13135 pupae 2d postWPP    5924 pupae 3d postWPP    4951 pupae 4d postWPP    10215 adult male 01day    9245 adult male 05day    10275 adult male 30day    8966 adult female 01day    7444 adult female 05day    3180 adult female 30day    4406 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (296) embryo 02-04hr  (2980) embryo 04-06hr  (11671) embryo 06-08hr  (21044) embryo 08-10hr  (21484) embryo 10-12hr  (24126) embryo 12-14hr  (14474) embryo 14-16hr  (10903) embryo 16-18hr  (6631) embryo 18-20hr  (7333) embryo 20-22hr  (9156) embryo 22-24hr  (10039) larva L1  (8474) larva L2  (13775) larva L3 12hr old  (8878) larva L3 puffstage 1-2  (13927) larva L3 puffstage 3-6  (14755) larva L3 puffstage 7-9  (20115) white prepupae new  (19845) white prepupae 12hr  (7736) white prepupae 24hr  (13135) pupae 2d postWPP  (5924) pupae 3d postWPP  (4951) pupae 4d postWPP  (10215) adult male 01day  (9245) adult male 05day  (10275) adult male 30day  (8966) adult female 01day  (7444) adult female 05day  (3180) adult female 30day  (4406) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    296 embryo 02-04hr  (2980) embryo 04-06hr  (11671) embryo 06-08hr  (21044) embryo 08-10hr  (21484) embryo 10-12hr  (24126) embryo 12-14hr  (14474) embryo 14-16hr  (10903) embryo 16-18hr  (6631) embryo 18-20hr  (7333) embryo 20-22hr  (9156) embryo 22-24hr  (10039) larva L1  (8474) larva L2  (13775) larva L3 12hr old  (8878) larva L3 puffstage 1-2  (13927) larva L3 puffstage 3-6  (14755) larva L3 puffstage 7-9  (20115) white prepupae new  (19845) white prepupae 12hr  (7736) white prepupae 24hr  (13135) pupae 2d postWPP  (5924) pupae 3d postWPP  (4951) pupae 4d postWPP  (10215) adult male 01day  (9245) adult male 05day  (10275) adult male 30day  (8966) adult female 01day  (7444) adult female 05day  (3180) adult female 30day  (4406) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    296 embryo 02-04hr    2980 embryo 04-06hr  (11671) embryo 06-08hr  (21044) embryo 08-10hr  (21484) embryo 10-12hr  (24126) embryo 12-14hr  (14474) embryo 14-16hr  (10903) embryo 16-18hr    6631 embryo 18-20hr    7333 embryo 20-22hr    9156 embryo 22-24hr  10039 larva L1    8474 larva L2  (13775) larva L3 12hr old    8878 larva L3 puffstage 1-2  (13927) larva L3 puffstage 3-6  (14755) larva L3 puffstage 7-9  (20115) white prepupae new  (19845) white prepupae 12hr    7736 white prepupae 24hr  (13135) pupae 2d postWPP    5924 pupae 3d postWPP    4951 pupae 4d postWPP  10215 adult male 01day    9245 adult male 05day  10275 adult male 30day    8966 adult female 01day    7444 adult female 05day    3180 adult female 30day    4406 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    296 embryo 02-04hr    2980 embryo 04-06hr    11671 embryo 06-08hr    21044 embryo 08-10hr    21484 embryo 10-12hr    24126 embryo 12-14hr    14474 embryo 14-16hr    10903 embryo 16-18hr    6631 embryo 18-20hr    7333 embryo 20-22hr    9156 embryo 22-24hr    10039 larva L1    8474 larva L2    13775 larva L3 12hr old    8878 larva L3 puffstage 1-2    13927 larva L3 puffstage 3-6    14755 larva L3 puffstage 7-9    20115 white prepupae new    19845 white prepupae 12hr    7736 white prepupae 24hr    13135 pupae 2d postWPP    5924 pupae 3d postWPP    4951 pupae 4d postWPP    10215 adult male 01day    9245 adult male 05day    10275 adult male 30day    8966 adult female 01day    7444 adult female 05day    3180 adult female 30day    4406 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0012037 expression level Developmental Stage   Expression Level embryo 00-02hr    296 embryo 02-04hr    2980 embryo 04-06hr    11671 embryo 06-08hr    21044 embryo 08-10hr    21484 embryo 10-12hr    24126 embryo 12-14hr    14474 embryo 14-16hr    10903 embryo 16-18hr    6631 embryo 18-20hr    7333 embryo 20-22hr    9156 embryo 22-24hr    10039 larva L1    8474 larva L2    13775 larva L3 12hr old    8878 larva L3 puffstage 1-2    13927 larva L3 puffstage 3-6    14755 larva L3 puffstage 7-9    20115 white prepupae new    19845 white prepupae 12hr    7736 white prepupae 24hr    13135 pupae 2d postWPP    5924 pupae 3d postWPP    4951 pupae 4d postWPP    10215 adult male 01day    9245 adult male 05day    10275 adult male 30day    8966 adult female 01day    7444 adult female 05day    3180 adult female 30day    4406 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (296) embryo 02-04hr  (2980) embryo 04-06hr  (11671) embryo 06-08hr  (21044) embryo 08-10hr  (21484) embryo 10-12hr  (24126) embryo 12-14hr  (14474) embryo 14-16hr  (10903) embryo 16-18hr  (6631) embryo 18-20hr  (7333) embryo 20-22hr  (9156) embryo 22-24hr  (10039) larva L1  (8474) larva L2  (13775) larva L3 12hr old  (8878) larva L3 puffstage 1-2  (13927) larva L3 puffstage 3-6  (14755) larva L3 puffstage 7-9  (20115) white prepupae new  (19845) white prepupae 12hr  (7736) white prepupae 24hr  (13135) pupae 2d postWPP  (5924) pupae 3d postWPP  (4951) pupae 4d postWPP  (10215) adult male 01day  (9245) adult male 05day  (10275) adult male 30day  (8966) adult female 01day  (7444) adult female 05day  (3180) adult female 30day  (4406) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    296 embryo 02-04hr  (2980) embryo 04-06hr  (11671) embryo 06-08hr  (21044) embryo 08-10hr  (21484) embryo 10-12hr  (24126) embryo 12-14hr  (14474) embryo 14-16hr  (10903) embryo 16-18hr  (6631) embryo 18-20hr  (7333) embryo 20-22hr  (9156) embryo 22-24hr  (10039) larva L1  (8474) larva L2  (13775) larva L3 12hr old  (8878) larva L3 puffstage 1-2  (13927) larva L3 puffstage 3-6  (14755) larva L3 puffstage 7-9  (20115) white prepupae new  (19845) white prepupae 12hr  (7736) white prepupae 24hr  (13135) pupae 2d postWPP  (5924) pupae 3d postWPP  (4951) pupae 4d postWPP  (10215) adult male 01day  (9245) adult male 05day  (10275) adult male 30day  (8966) adult female 01day  (7444) adult female 05day  (3180) adult female 30day  (4406) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    296 embryo 02-04hr    2980 embryo 04-06hr  11671 embryo 06-08hr  (21044) embryo 08-10hr  (21484) embryo 10-12hr  (24126) embryo 12-14hr  14474 embryo 14-16hr  10903 embryo 16-18hr    6631 embryo 18-20hr    7333 embryo 20-22hr    9156 embryo 22-24hr  10039 larva L1    8474 larva L2  13775 larva L3 12hr old    8878 larva L3 puffstage 1-2  13927 larva L3 puffstage 3-6  14755 larva L3 puffstage 7-9  20115 white prepupae new  19845 white prepupae 12hr    7736 white prepupae 24hr  13135 pupae 2d postWPP    5924 pupae 3d postWPP    4951 pupae 4d postWPP  10215 adult male 01day    9245 adult male 05day  10275 adult male 30day    8966 adult female 01day    7444 adult female 05day    3180 adult female 30day    4406 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    296 embryo 02-04hr    2980 embryo 04-06hr    11671 embryo 06-08hr    21044 embryo 08-10hr    21484 embryo 10-12hr    24126 embryo 12-14hr    14474 embryo 14-16hr    10903 embryo 16-18hr    6631 embryo 18-20hr    7333 embryo 20-22hr    9156 embryo 22-24hr    10039 larva L1    8474 larva L2    13775 larva L3 12hr old    8878 larva L3 puffstage 1-2    13927 larva L3 puffstage 3-6    14755 larva L3 puffstage 7-9    20115 white prepupae new    19845 white prepupae 12hr    7736 white prepupae 24hr    13135 pupae 2d postWPP    5924 pupae 3d postWPP    4951 pupae 4d postWPP    10215 adult male 01day    9245 adult male 05day    10275 adult male 30day    8966 adult female 01day    7444 adult female 05day    3180 adult female 30day    4406 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0012037    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0012037 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: larval/adult midgut, larval hindgut, larval fat body, adult salivary gland, larval trachea, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult hindgut, larval Malpighian tubules, adult heart, adult fat body, adult spermathecae, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0012037 expression level Tissue   Expression Level Larval Central Nervous System    120.075 Larval Midgut    2694.7 Larval Hindgut    902.7 Larval Malpighian Tubules    275.5 Larval Fat Body    836.8 Larval Salivary Gland    86.5 Larval Trachea    2858.7 Larval Carcass    676.675 Adult Head    193.7 Adult Eye    156.275 Adult Brain    101.4 Adult Thoracic-Abdominal Ganglion    213.2 Adult Crop    40.7 Adult Midgut    3626.5 Adult Hindgut    470.7 Adult Malpighian Tubules    30.1 Adult Fat Body    493 Adult Salivary Gland    1480.6 Adult Heart    490.5 Adult VirginFemale Spermatheca    339.1 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    19 Adult Testis    246.2 Adult Male Accessory Gland    320.2 Adult Carcass    397.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    120.075 Larval Midgut  (2694.7) Larval Hindgut  (902.7) Larval Malpighian Tubules    275.5 Larval Fat Body  (836.8) Larval Salivary Gland    86.5 Larval Trachea  (2858.7) Larval Carcass  (676.675) Adult Head    193.7 Adult Eye    156.275 Adult Brain    101.4 Adult Thoracic-Abdominal Ganglion    213.2 Adult Crop    40.7 Adult Midgut  (3626.5) Adult Hindgut    470.7 Adult Malpighian Tubules    30.1 Adult Fat Body    493 Adult Salivary Gland  (1480.6) Adult Heart    490.5 Adult VirginFemale Spermatheca    339.1 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    19 Adult Testis    246.2 Adult Male Accessory Gland    320.2 Adult Carcass    397.4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    120.075 Larval Midgut  (2694.7) Larval Hindgut    902.7 Larval Malpighian Tubules    275.5 Larval Fat Body    836.8 Larval Salivary Gland    86.5 Larval Trachea  (2858.7) Larval Carcass    676.675 Adult Head    193.7 Adult Eye    156.275 Adult Brain    101.4 Adult Thoracic-Abdominal Ganglion    213.2 Adult Crop    40.7 Adult Midgut  (3626.5) Adult Hindgut    470.7 Adult Malpighian Tubules    30.1 Adult Fat Body    493 Adult Salivary Gland  (1480.6) Adult Heart    490.5 Adult VirginFemale Spermatheca    339.1 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    19 Adult Testis    246.2 Adult Male Accessory Gland    320.2 Adult Carcass    397.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    120.075 Larval Midgut    2694.7 Larval Hindgut    902.7 Larval Malpighian Tubules    275.5 Larval Fat Body    836.8 Larval Salivary Gland    86.5 Larval Trachea    2858.7 Larval Carcass    676.675 Adult Head    193.7 Adult Eye    156.275 Adult Brain    101.4 Adult Thoracic-Abdominal Ganglion    213.2 Adult Crop    40.7 Adult Midgut    3626.5 Adult Hindgut    470.7 Adult Malpighian Tubules    30.1 Adult Fat Body    493 Adult Salivary Gland    1480.6 Adult Heart    490.5 Adult VirginFemale Spermatheca    339.1 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    19 Adult Testis    246.2 Adult Male Accessory Gland    320.2 Adult Carcass    397.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0012037 expression level Tissue   Expression Level Larval Central Nervous System    120.075 Larval Midgut    2694.7 Larval Hindgut    902.7 Larval Malpighian Tubules    275.5 Larval Fat Body    836.8 Larval Salivary Gland    86.5 Larval Trachea    2858.7 Larval Carcass    676.675 Adult Head    193.7 Adult Eye    156.275 Adult Brain    101.4 Adult Thoracic-Abdominal Ganglion    213.2 Adult Crop    40.7 Adult Midgut    3626.5 Adult Hindgut    470.7 Adult Malpighian Tubules    30.1 Adult Fat Body    493 Adult Salivary Gland    1480.6 Adult Heart    490.5 Adult VirginFemale Spermatheca    339.1 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    19 Adult Testis    246.2 Adult Male Accessory Gland    320.2 Adult Carcass    397.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    120.075 Larval Midgut  (2694.7) Larval Hindgut  (902.7) Larval Malpighian Tubules    275.5 Larval Fat Body  (836.8) Larval Salivary Gland    86.5 Larval Trachea  (2858.7) Larval Carcass  676.675 Adult Head    193.7 Adult Eye    156.275 Adult Brain    101.4 Adult Thoracic-Abdominal Ganglion    213.2 Adult Crop    40.7 Adult Midgut  (3626.5) Adult Hindgut    470.7 Adult Malpighian Tubules    30.1 Adult Fat Body    493 Adult Salivary Gland  (1480.6) Adult Heart    490.5 Adult VirginFemale Spermatheca    339.1 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    19 Adult Testis    246.2 Adult Male Accessory Gland    320.2 Adult Carcass    397.4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    120.075 Larval Midgut  (2694.7) Larval Hindgut    902.7 Larval Malpighian Tubules    275.5 Larval Fat Body    836.8 Larval Salivary Gland    86.5 Larval Trachea  (2858.7) Larval Carcass    676.675 Adult Head    193.7 Adult Eye    156.275 Adult Brain    101.4 Adult Thoracic-Abdominal Ganglion    213.2 Adult Crop    40.7 Adult Midgut  (3626.5) Adult Hindgut    470.7 Adult Malpighian Tubules    30.1 Adult Fat Body    493 Adult Salivary Gland  1480.6 Adult Heart    490.5 Adult VirginFemale Spermatheca    339.1 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    19 Adult Testis    246.2 Adult Male Accessory Gland    320.2 Adult Carcass    397.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    120.075 Larval Midgut    2694.7 Larval Hindgut    902.7 Larval Malpighian Tubules    275.5 Larval Fat Body    836.8 Larval Salivary Gland    86.5 Larval Trachea    2858.7 Larval Carcass    676.675 Adult Head    193.7 Adult Eye    156.275 Adult Brain    101.4 Adult Thoracic-Abdominal Ganglion    213.2 Adult Crop    40.7 Adult Midgut    3626.5 Adult Hindgut    470.7 Adult Malpighian Tubules    30.1 Adult Fat Body    493 Adult Salivary Gland    1480.6 Adult Heart    490.5 Adult VirginFemale Spermatheca    339.1 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    19 Adult Testis    246.2 Adult Male Accessory Gland    320.2 Adult Carcass    397.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    193.7   NA  Eye    156.275   NA  Brain    101.4   120.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    213.2   NA  Crop    40.7   2694.7  Midgut    3626.5   902.7  Hindgut    470.7   275.5  Malpighian Tubules    30.1   836.8  Fat Body    493   86.5  Salivary Gland    1480.6   NA  Heart    490.5   2858.7  Trachea    NA   NA  VirginFemale Spermatheca    339.1   NA  InseminatedFemale Spermatheca    410.3   NA  Ovary    19   NA  Testis    246.2   NA  Male Accessory Gland    320.2   676.675  Carcass    397.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0012037 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8827-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Ance Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | recessive Ance34Eb-1 Ance34Eb-2 semi-viable (with Ance34Eb-1) Ance34Eb-2 semi-viable (with Ance34Eb-2) Ance34Eb-1 viable Ance34Eb-2 viable, with Scer\GAL4pnr-MD237 AnceGD5388 Sterility Allele male sterile Ance34Eb-2 male sterile (with Ance34Eb-1) Ance34Eb-2 male sterile (with Ance34Eb-2) Ance34Eb-1 male sterile (with Df(2L)BSC694) Ance34Eb-2 Other Phenotypes Allele wild-type Ance+t16.5 Phenotype manifest in Allele major mitochondrial derivative (with Df(2L)Adh-nBR55) Ance34Eb-1 minor mitochondrial derivative (with Df(2L)Adh-nBR55) Ance34Eb-1 primary spermatocyte cyst (with Df(2L)Adh-nBR55) Ance34Eb-1 spermatid (with Df(2L)Adh-nBR55) Ance34Eb-1 spermatid & nucleus (with Df(2L)Adh-nBR55) Ance34Eb-1 testis Ance34Eb-2 testis (with Ance34Eb-1) Ance34Eb-2 testis (with Ance34Eb-2) Ance34Eb-1 testis (with Df(2L)Adh-nBR55) Ance34Eb-1 Ance34Eb-2 testis (with Df(2L)b88f32) Ance34Eb-1 Ance34Eb-2
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Ance Class Mutagen Stocks Known lesion Ance34Eb-1 ethyl methanesulfonate 1 -- Ance34Eb-2 ethyl methanesulfonate 1 -- AnceMB09828 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ance Class Mutagen Stocks Known lesion AnceGD5388 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ance+t16.5 in vitro construct - genomic fragment 0 Yes Ancemt353 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)A47 (Ashburner et al., 1982, Gubb et al., 1990, Fossett et al., 1994, Roote et al., 1996, Roote, 1996.8, Roote, 1997.6.3) Df(2L)Adh-nBR55 (Roote, 1995.3.24, Tatei et al., 1995, Roote, 1997.6.3) Df(2L)Adh-nBR101 (Fossett et al., 1994) Df(2L)Adh-nBR130 (Fossett et al., 1994) Df(2L)b74c6 (Roote, 1995.3.27) Df(2L)b75 (Gubb et al., 1990) Df(2L)b80c1 (Iyengar et al., 1999, Ashburner et al., 1982) Df(2L)b80f1 (Roote, 1995.3.27) Df(2L)b80l (Roote, 1995.3.27) Df(2L)b82a2 (Tatei et al., 1995) Df(2L)b88f32 (Roote, 1995.3.27, Tatei et al., 1995) Df(2L)BSC252 (Christensen and Cook, 2007.3.22) Df(2L)BSC253 (Christensen and Cook, 2007.3.22) Df(2L)BSC694 (Christensen et al., 2008.12.28) Df(2L)el80i1 (Roote, 1997.6.3) Df(2L)el82f1 (Roote, 1997.6.3) Df(2L)fn30 (Ashburner et al., 1982) Df(2L)fn31 (Ashburner et al., 1982) Df(2L)GT5 (Gubb et al., 1990) Df(2L)k07245-mr2 (Roote, 2000.6.13) Df(2L)rN149-rv3 (Roote, 2000.6.13) Df(2L)TE35B-5 (Gubb et al., 1985) Df(2L)TE35B-407 (Roote, 1995.3.27, Roote et al., 1996, Roote, 1997.6.3) Df(2L)TE35BC-6 (Gubb et al., 1984) Df(2L)TE35BC-23 (Gubb et al., 1984) In(2L)b82a1 (Roote, 1995.3.27)
Not disrupted in	Df(2L)A48 (Ashburner et al., 1982, Gubb et al., 1990, Fossett et al., 1994) Df(2L)A63 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A72 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A178 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A215 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A217 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A220 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A245 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A246 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A260 (Ashburner et al., 1982) Df(2L)A263 (Ashburner et al., 1982) Df(2L)A264 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A266 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A267 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A337 (Fossett et al., 1994) Df(2L)A376 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A377 (Ashburner et al., 1982) Df(2L)A379 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A400 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A445 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)Adh-nBR100 (Fossett et al., 1994) Df(2L)Adh-nBR102 (Fossett et al., 1994) Df(2L)Adh-nBR103 (Fossett et al., 1994) Df(2L)Adh-nBR105 (Fossett et al., 1994) Df(2L)Adh-nBR106 (Fossett et al., 1994) Df(2L)Adh-nBR107 (Fossett et al., 1994) Df(2L)Adh-nBR117 (Fossett et al., 1994) Df(2L)Adh-nBR118 (Fossett et al., 1994) Df(2L)Adh-nBR119 (Fossett et al., 1994) Df(2L)Adh-nBR120 (Fossett et al., 1994) Df(2L)Adh-nBR121 (Fossett et al., 1994) Df(2L)Adh-nBR122 (Fossett et al., 1994) Df(2L)Adh-nBR125 (Fossett et al., 1994) Df(2L)Adh-nBR126 (Fossett et al., 1994) Df(2L)Adh-nBR127 (Fossett et al., 1994) Df(2L)Adh-nBR128 (Fossett et al., 1994) Df(2L)Adh-nBR129 (Fossett et al., 1994) Df(2L)Adh-nBR131 (Fossett et al., 1994) Df(2L)b81l42 (Roote, 2000.7.3, Roote, 1997.6.3) Df(2L)b83l1 (Roote, 2000.7.3, Roote, 1997.6.3) Df(2L)b84a9 (Roote, 2000.7.3, Roote, 1997.6.3) Df(2L)b85b1 (Roote, 2000.7.3, Roote, 1997.6.3) Df(2L)b88g83 (Roote, 2000.7.3, Tatei et al., 1995, Roote, 1997.6.3) Df(2L)fn1 (Ashburner et al., 1982) Df(2L)fn2 (Ashburner et al., 1982) Df(2L)fn3 (Ashburner et al., 1982) Df(2L)fn5 (Ashburner et al., 1982) Df(2L)fn7 (Ashburner et al., 1982, Tatei et al., 1995) Df(2L)fn12 (Ashburner et al., 1982) Df(2L)fn15 (Ashburner et al., 1982) Df(2L)fn26 (Ashburner et al., 1982) Df(2L)fn27 (Ashburner et al., 1982) Df(2L)fn36 (Ashburner et al., 1982) Df(2L)GT4 (Gubb et al., 1990) Df(2L)noc11 (Tatei et al., 1995) Df(2L)TE35B-1 (Gubb et al., 1985) Df(2L)TE35B-2 (Gubb et al., 1985) Df(2L)TE35B-3 (Gubb et al., 1985) Df(2L)TE35B-4 (Gubb et al., 1985) Df(2L)TE35B-6 (Gubb et al., 1985) Df(2L)TE35B-7 (Gubb et al., 1985) Df(2L)TE35B-8 (Gubb et al., 1985) Df(2L)TE35B-9 (Gubb et al., 1985, Tatei et al., 1995) Df(2L)TE35B-10 (Gubb et al., 1985) Df(2L)TE35B-11 (Gubb et al., 1985) Df(2L)TE35B-12 (Gubb et al., 1985) Df(2L)TE35B-15 (Gubb et al., 1985) Df(2L)TE35BC-1 (Gubb et al., 1984) Df(2L)TE35BC-3 (Gubb et al., 1984) Df(2L)TE35BC-4 (Gubb et al., 1984) Df(2L)TE35BC-7 (Gubb et al., 1984) Df(2L)TE35BC-8 (Gubb et al., 1984) Df(2L)TE35BC-24 (Gubb et al., 1984) Df(2L)TE35BC-28 (Gubb et al., 1984) Df(2L)TE35BC-29 (Gubb et al., 1984) Df(2L)TE35BC-31 (Gubb et al., 1984) Df(2L)TE35BC-34 (Gubb et al., 1984) Df(2L)TE35BC-35 (Gubb et al., 1984) In(2L)b88e45 (Roote, 1997.6.3) In(2L)TE35B-13 (Gubb et al., 1985) Tp(2;2)A446 (Ashburner et al., 1982, Fossett et al., 1994) Tp(2;3)dp (Roote, 1997.6.3)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data reporter construct P{533-Race} No P{Ance-0.5-lacZ} No P{Ance-0.8-lacZ} No P{Ance-1.1-lacZ} No P{Ance-1.5-lacZ} No P{Ance-2.0-lacZ} No P{Ance-2.4-lacZ} No P{Ance-4.4-lacZ} No P{Ance-lacZ.AeBeCe} No P{Ance-lacZ.Am} No P{Ance-lacZ.AmBm} No P{Ance-lacZ.AmBmCm} No P{Ance-lacZ.Bm} No P{Ance-lacZ.Cm} No P{Ance-lacZ.wt} No P{zen-lacZ.Mdel} No P{Δzen-lacZ} No UAS construct P{GD5388} NA characterization construct P{mtRACE} NA P{RACE} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}AnceMB09828 No
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
peptidyl-dipeptidase activity inferred from direct assay (Cornell et al., 1995)
Biological Process
CV term Evidence References
metamorphosis inferred from expression pattern (Siviter et al., 2002) response to symbiotic bacterium inferred from expression pattern (Xi et al., 2008) inferred from mutant phenotype (Xi et al., 2008) spermatid nucleus differentiation inferred from mutant phenotype (Hurst et al., 2003) sperm individualization inferred from mutant phenotype (Hurst et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
metallopeptidase activity inferred from electronic annotation with InterPro:IPR001548 (FlyBase Curators et al., 2004-) peptidyl-dipeptidase activity non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) traceable author statement (Coates et al., 2000) zinc ion binding non-traceable author statement (Swiss-Prot Project Members, 1997.2.1)
Biological Process
CV term Evidence References
proteolysis inferred from electronic annotation with InterPro:IPR001548 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
extracellular region non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) membrane inferred from electronic annotation with InterPro:IPR001548 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ance allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60835 DroID - A comprehensive database of gene and protein interactions. • FBgn0012037 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34805
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14268 Dsim\Ance Dyak\GE18694
Curated drosophilid orthologs	Dpse\GA21350   Dsim\Ance (Swanson et al., 2004)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009310-PA Aedes aegypti (mosquito) AGAP009755-PA Anopheles gambiae (mosquito) XP_393561.2 Apis mellifera (honey bee) XP_001944565.1 Acyrthosiphon pisum (pea aphid) 68301 Branchiostoma floridae (lancelet) BGIBMGA002526-PA Bombyx mori (silk worm) ENSBTAP00000048908 Bos taurus (bovine) ENSCAFP00000017867 Canis familiaris (dog) CPIJ009106 Culex pipens (mosquito) ENSCPOP00000015145 Cavia porcellus (guinea pig) ENSCSAVP00000009461 Ciona savignyi (sedentary tunicate) 175968 Capitella spl (polychaete worm) 243454 Daphnia pulex (daphnia) ENSECAP00000021834 Equus caballus (horse) ENSGACP00000019926 Gymnopilus aculeatus (mushroom) 111546 Hypsipyla robusta (cedar shoot borer) ENSP00000252519 Homo sapiens (human) ISCW005573-PA Ixodes scapularis (deer tick) 161404 Lottia gigantea (owl limpet) ENSMODP00000021483 Monodelphis domestica (gray opossum) ENSMMUP00000018466 Macaca mulatta (rhesus monkey) ENSMUSP00000107890 Mus musculus (house mouse) 210990 Nematostella vectensis (starlet anemone) ENSOANP00000006295 Ornithorynchus anatinus (platypus) ENSORLP00000005402 Oryzias latipes (japanese killifish) PHUM010635-PA Pediculus humanus (human body louse) ENSPPYP00000022536 Pongo pygmaeus (orangutan) ENSPTRP00000037158 Pan troglodytes (chimpanzee) ENSRNOP00000047913 Rattus norvegicus (norway rat) XP_798092.2 Strongylocentrotus purpuratus (purple sea urchin) XP_969553.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012378 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000043659 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15022 LH23526 ISCW010296 ISCW005573 FBgn0236092 FBgn0217024 FBgn0205321 FBgn0195302 FBgn0170272 FBgn0250136 JGI_V11_307858 JGI_V11_243454 JGI_V11_304127 FBgn0249170 FBgn0244537 FBgn0158841 FBgn0158838 FBgn0158837 FBgn0158667 FBgn0135393 FBgn0118606 FBgn0116034 FBgn0091295 CPIJ009107 BGIBMGA002527 BGIBMGA002526 ACYPI008911 GB11983 ANCE6 ANCE5 ANCE3 ANCE4 AAEL017460 PHUM522500 GLEAN_11052
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	27809 w1118; Mi{ET1}AnceMB09828 3584 Ance34Eb-2 AdhD pr1 cn1/CyO, AdhnB
Kyoto	101358 CyO, Cy1 dplv1 AdhnB pr1 cn2 / Ance34Eb-1 AdhD pr1 cn1
VDRC	v41219 w1118; P{GD5388}v41219
Genomic Clones ( 1 )
	BACR16P12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 339 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD11258
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09244 AT18424 AT23786 AT29950 GH06818 GH18241 GH24562 GH25514 GM02190 LD06090 LD17344 LD38889 LD46859 LP04188 LP04701 LP04793 LP08832 LP09024 LP09065 LP09781 LP16227 LP19173 LP19413 RE11483 RE15888 RE16251 RE17835 RE18049 RE26539 RE26876 RE29350 RE31372 RE37189 RE46456 RE46462 RE48376 RE48507 RE58443 RE61211 RE65231 RE72873 RE73024 RH29570 RH41417 RH60072 RH68427
Other clones	44285 64443 80968 101962 121418 144896 146424 149074 149204 149937 157170 AA433287 Arica_10_D11 AT24756 AT25739 CK01.8A.D7 CK01.87B.D5 CK01.120A.G2 CK01.123B.G7 Dmel_neb_007941_0197_0898 Dmel_neb_014109_0347_2236 EC13702 EC39393 EC051637 EC052638 EC054117 EC055952 EK010916 EK069015 EK091609 EK091657 EK159712 EK180409 EK191346 EK249326 EK251411 EK252050 EK254718 EK260522 IP03625 IP03825 IP03925 IP08831 IP09031 RP003000587 RP003006477 RP003010058 RP003034980 RP003038685 RP003048619 RP003051466 RP003053236 RP003060169 RP003060680 RP003062910 RP003065986 RP003067920 RP003070985 RP003074896 RP003075441 RP003080220 RP003083574 RP003089214 RP003091331 RP003094597 RP003095377 RP003101869 RP003106960 RP003110830 RP003126736 RP003129901 RP003133400 RP003135227 RP003137068 RP003141624 RP003146828 RP003149219 RP003150095 RP003150381 RP003151292 RP003155419 RP003158975 RP003160257 RP003160824 RP003161980 RP003163858 RP003164290 RP003166523 RP003166576 RP003167453 RP003168330 RP003172689 RP003173418 RP003176684 RP003176906 RP003177320 RP003181248 RP003181497 RP003182642 RP003185691 RP003185999 RP003187764 RP003187937 RP003189317 RP003194506 RP003196548 RP003196686 RP003201666 RP003204202 RP003206288 RP003206755 RP003211823 RP003214027 RP003215646 RP003215998 RP003227986 RP003232426 RP003232792 RP003235196 RP003235349 RP003236065 RP003237939 RP003237940 RP003238604 RP003239558 RP003241372 RP003242893 RP003243542 RP003243740 RP003246578 RP003247736 RP003248266 RP003252532 RP003253329 RP003255699 RP003255946 RP003258377 RP003260803 RP003262120 RP003262810 RP003266000 RP003269231 RP003269994 RP003270752 RP003272057 RP003274932 RP003276059 RP003280681 RP003280719 RP003281275 RP003281825 RP003290538 RP003290647 RP003297664 RP003298275 RP003301927 RP003302714 RP003305162 RP003307602 RP003308512 RP003310825 RP003311067 RP003313099 RP003318389 RP003321890 RP003324453 RP003325315 RP003325434 RP003326228 RP003328340 RP003328623 RP003329291 RP003330527 RP003331336 RP003332678 RP003332964 RP003333456 RP003334136 RP003338045 RP003338275 RP003339192 RP003340625 RP003342101 RP003342327 RP003343072 RP003343209 RP003345443 RP003346310 RP003349295 RP003350886 RP003352194 RP003354182 RP003355814 RP003390791 RP003392846 RP003394462 RP003395472 RP003401130 RP003407312 RP003411951 RP003415503 RP003416495 RP003421534 RP003424597 RP003425005 RP003428849 RP003429056 RP003436979 RP003446641 RP003447787 RP003451332 RP003461811 RP003467437 RP003470006 RP003477272 RP003477970 RP003483271 RP003491805 RP003502846 RP003505348 RP003509196 RP003515671 RP003517892 RP003518101 RP003518382 RP003519450 RP003525448 RP003525464 RP003532575 RP003532940 RP003537683 RP003538165 RP003538608 RP003542008 RP003548487 RP003549232 RP003552978 RP003553259 RP003554009 RP003554741 RP003555708 RP003556844 RP003556869 RP003558822 RP003564481 RP003568213 RP003569262 RP003574376 RP003576448 RP003577601 RP003579461 RP003587158 RP003588019 RP003594025 RP003594571 RP003595559 RP003597253 RP003597546 RP003598563 RP003603826 RP003608433 RP003609070 RP003612314 RP003612378 RP003617129 RP003617584 RP003618510 RP003621611 RP003623046 RP003624066 RP003628133 RP003632263 RP003636328 RP003637640 RP003638739 RP003638831 RP003643689 RP003649584 RP003652838 RP003655582 RP003655701 RP003663270 RP003663933 RP003665894 RP003667369 RP003668569 RP003669557 RP003670495 RP003670681 RP003677371 RP003681978 RP003682501
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0012037 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34805
Antibody Information
	polyclonal (Rylett et al., 2007)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ance CG8827 (Guan, 1999.11)
Source for database merge of	Source for merge of: Ance anon-EST:fe3D10 (Bayraktaroglu, 2000.11.2)
Additional comments	Heteroallelic combinations escape about 10% with thin bristles; female fertile; male sterile.
Other Comments
	Ance is required for spermatid differentiation, probably through processing of a regulatory peptide synthesised within the developing cyst. (Hurst et al., 2003) zen directly activates the amnioserosa-specific expression of a downstream target gene, Ance. (Rusch and Levine, 1997) Isolated from a 4-8 hour embryo cDNA library, using a fragment of a human ACE cDNA as a probe. (Cornell et al., 1995) An Ance cDNA has been cloned. (Cornell et al., 1995) A putative dpp/zen target gene, Ance, a homologue of the angiotensin converting enzyme, is expressed in the presumptive amnioserosa. The dpp signal leads to activation of Ance and to the determination of different dorsal cell fates. (Rusch et al., 1995) Ance has been cloned and sequenced, and its expression pattern has been analysed. (Tatei et al., 1995) The Coates and Levine groups published conflicting map locations and their submitted sequences conflicted in several places, but subsequent work has confirmed that their genes are the same. Clarification is in FBrf0089312.   Encodes a zinc metallopeptidase similar to mammalian angiotensin converting enzyme. Expressed in the amnioserosa and may be a target for dpp and zen.   Loss of function is lethal, although escapers or heteroallelic combinations may show thin bristles and are sterile.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057698 NM_165070 RefSeq (Proteins) • NP_477046 NP_723852 DDBJ / EMBL / GenBank • AA246993 AA392405 AA433287 AA536582 AA694939 AA695131 AAB02171 AAC46902 AAF44834 AAF53353 AAL28677 AAN10856 AC092223 AE003408 AW942183 AY061129 L80114 U25344 U34599 Entrez Gene - A searchable database of RefSeq genes. • 34805 UniProtKB/Swiss-Prot • Q10714
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M2, peptidyl-dipeptidase A (IPR001548) MEROPS - An information resource for peptidases and the proteins that inhibit them • M02.003
Linkouts
	BioGRID - A database of protein and genetic interactions • 60835 DroID - A comprehensive database of gene and protein interactions. • FBgn0012037 DRSC - Results from RNAi screens. • FBgn0012037 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0012037 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8827-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0012037 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34805 InParanoid A subset of ortholog calls from InParanoid. • AAEL009310-PA Aedes aegypti (mosquito) AGAP009755-PA Anopheles gambiae (mosquito) XP_393561.2 Apis mellifera (honey bee) XP_001944565.1 Acyrthosiphon pisum (pea aphid) 68301 Branchiostoma floridae (lancelet) BGIBMGA002526-PA Bombyx mori (silk worm) ENSBTAP00000048908 Bos taurus (bovine) ENSCAFP00000017867 Canis familiaris (dog) CPIJ009106 Culex pipens (mosquito) ENSCPOP00000015145 Cavia porcellus (guinea pig) ENSCSAVP00000009461 Ciona savignyi (sedentary tunicate) 175968 Capitella spl (polychaete worm) 243454 Daphnia pulex (daphnia) ENSECAP00000021834 Equus caballus (horse) ENSGACP00000019926 Gymnopilus aculeatus (mushroom) 111546 Hypsipyla robusta (cedar shoot borer) ENSP00000252519 Homo sapiens (human) ISCW005573-PA Ixodes scapularis (deer tick) 161404 Lottia gigantea (owl limpet) ENSMODP00000021483 Monodelphis domestica (gray opossum) ENSMMUP00000018466 Macaca mulatta (rhesus monkey) ENSMUSP00000107890 Mus musculus (house mouse) 210990 Nematostella vectensis (starlet anemone) ENSOANP00000006295 Ornithorynchus anatinus (platypus) ENSORLP00000005402 Oryzias latipes (japanese killifish) PHUM010635-PA Pediculus humanus (human body louse) ENSPPYP00000022536 Pongo pygmaeus (orangutan) ENSPTRP00000037158 Pan troglodytes (chimpanzee) ENSRNOP00000047913 Rattus norvegicus (norway rat) XP_798092.2 Strongylocentrotus purpuratus (purple sea urchin) XP_969553.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012378 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000043659 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34805 modMine - Data generated by the modENCODE project. • FBgn0012037 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15022 LH23526 ISCW010296 ISCW005573 FBgn0236092 FBgn0217024 FBgn0205321 FBgn0195302 FBgn0170272 FBgn0250136 JGI_V11_307858 JGI_V11_243454 JGI_V11_304127 FBgn0249170 FBgn0244537 FBgn0158841 FBgn0158838 FBgn0158837 FBgn0158667 FBgn0135393 FBgn0118606 FBgn0116034 FBgn0091295 CPIJ009107 BGIBMGA002527 BGIBMGA002526 ACYPI008911 GB11983 ANCE6 ANCE5 ANCE3 ANCE4 AAEL017460 PHUM522500 GLEAN_11052 REDfly - A database of transcriptional regulatory elements. • FBgn0012037
Synonyms & Secondary IDs ( 22 )
Reported As
Symbol Synonym	ACE (Isaac et al., 2002, Schoofs et al., 1998, Isaac et al., 1998, Shirras et al., 2005, Smith et al., 2005) ance (Miotto et al., 2006) AnCE (Kim et al., 2003, Zhu et al., 2001, Williams et al., 1996, Cornell et al., 1995, Akif et al., 2010, Akif et al., 2010) Ance (Dionne et al., 2006, Christensen and Cook, 2007.3.22, Christensen and Cook, 2007.3.22, Tarone et al., 2008, Christensen et al., 2008.12.28, Wang et al., 2008, Rylett et al., 2007, Flaherty et al., 2009, Xi et al., 2008) ANCE (Xi et al., 2008, Bingham et al., 2006) anon-EST:fe3D10   BG:DS08220.3 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) br31 (Gubb et al., 1985) CG8827 (Gonzalez-Aguero et al., 2005, Swanson et al., 2004, Moorman et al., 2006) l34Eb (Fossett et al., 1994) l(2)34Eb (Ashburner et al., 1999, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Alexandrova et al., 1996, Roote et al., 1996, Spradling et al., 1995, Gubb et al., 1990, ) l(2)br31 (Gubb et al., 1984, Ashburner et al., 1982, ) Race (Ashe, 2006, Xu et al., 2005, Okumura et al., 2005, Wharton et al., 2004, Xu et al., 2005, Xu et al., 2004, Kumar et al., 2002, Xu et al., 2003, Xu et al., 2002, Gurdon and Bourillot, 2001, Decotto and Ferguson, 2001, Ross et al., 2001, Ashe et al., 2000, Tatei, 1995.8.21, Podos and Ferguson, 1999, Ashe and Levine, 1999, Rusch and Levine, 1997, Frank and Rushlow, 1996, Tatei et al., 1995, Rusch et al., 1995, Lin et al., 2006, Liang et al., 2007, Mizutani et al., 2005, Bonds et al., 2007, Haecker et al., 2008, Miles et al., 2008, Wang et al., 2008) race (Levine and Davidson, 2005, Shimmi et al., 2005, Yu et al., 2004, Kunwar et al., 2003, Chang et al., 2003, Reim et al., 2003, Stathopoulos et al., 2002, Eldar et al., 2002, Chang et al., 2001, Yu et al., 2000, Riesgo-Escovar and Hafen, 1997, Biehs et al., 1996, Stathopoulos and Levine, 2005, Gurunathan et al., 2004) RACE (Stein et al., 2002) unnamed (Schmid and Tautz, 1997)
Name Synonym	Angiotensin converting enzyme (Hurlbut et al., 2009, Flaherty et al., 2009) Angiotensin Converting Enzyme (Xi et al., 2008) angiotensin-converting enzyme (Bingham et al., 2006) Angiotensin I-converting enzyme (Rylett et al., 2007) anon-fast-evolving-3D10   Related to angiotensin converting enzyme
Secondary FlyBase IDs
	FBgn0014013 FBgn0025190
References ( 127 )
Generate a list of	All references relating to this gene ( 127 )
List References by type	Research paper  ( 74 ) Supplementary material  ( 6 ) Review  ( 6 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 16 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 4 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Akif et al., 2010, J. Mol. Biol. 400(3): 502--517 High-Resolution Crystal Structures of Drosophila melanogaster Angiotensin-Converting Enzyme in Complex with Novel Inhibitors and Antihypertensive Drugs. [FBrf0211212] Akif et al., 2010, Biochem. Biophys. Res. Commun. 398(3): 532--536 Crystal structure of a phosphonotripeptide K-26 in complex with angiotensin converting enzyme homologue (AnCE) from Drosophila melanogaster. [FBrf0211432] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...