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Gene Dmel\AttA

General Information
Symbol	Dmel\AttA	Species	D. melanogaster
Name	Attacin-A	Annotation symbol	CG10146
Feature type	protein_coding_gene	FlyBase ID	FBgn0012042
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	att, Att A
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	51C1-51C1	Sequence location	2R:10,634,876..10,635,699 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Attacin-A is referred to in FlyBase by the symbol Dmel\AttA (CG10146, FBgn0012042). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: humoral immune response; defense response to Gram-positive bacterium; defense response to Gram-negative bacterium; antibacterial humoral response. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Attacin, C-terminal; Attacin, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: virgin spermatheca. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval fat body, inseminated spermatheca. Comments on Affy2 ProbeSet: ProbeSet 1625124_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of AttA. Gene sequence location is 2R:10634876..10635699.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN42224 HFA05926 References Clark et al., 2011, Curr. Biol. 21(19): 1672--1677 Thevenon et al., 2009, Cell Host Microbe 6(4): 309--320 Kim et al., 2010, Exp. Gerontol. 45(12): 984--987 Rao et al., 2011, Insect Biochem. Mol. Biol. 41(12): 982--992
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 51C1-51C1   Limits computationally determined from genome sequence between P{lacW}ttvk03617&P{EP}ttvEP765 and P{lacW}Rpn6k00103
Experimentally Determined Cytological Location
Cytogenetic map Notes References 51A-51B     (Dushay, 2000.1.3) 51A-51B   (determined by in situ hybridisation)   (Asling et al., 1995)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\AttA for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) AttA-RA FBtr0087437  NM_079021   760   221
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein AttA-PA   FBpp0086567   22.9   221   10.54     NP_523745   AAF58215
Additional Polypeptide Data & Comments
Reported size (kDa)	224 (aa) (Dushay et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Attacin, N-terminal (IPR005520) Attacin, C-terminal (IPR005521)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58215   AC007580   AF220544 AAF70455   AI257408   AW944054   AX154656   AY056855 AAL23641   AY056856 AAL23642   AY056857 AAL23643   AY056858 AAL23644   AY056859   AY056860 AAL23645   AY056861 AAL23646   AY056862 AAL23647   AY056863 AAL23648   AY056864 AAL23649   AY056865 AAL23650   AY056866 AAL23651   AY056891   AY056892   AY056893   AY056894   AY056895   AY056896   AY056897   AY056898   AY056899   AY056900   AY056901   AY056902   AY060448 AAL25487   AY060448 AAO24989   BT011154   CA805407   CO152844   CO154227   CO155160   CO155698   CO336447   CO336730   CO337510   CO337784   CO338144   CO338708   EC262372   EC262592   EC264474   EC265079   EC267362   EV584166   Z46893 CAA86995
UniProtKB/Swiss-Prot	P45884
UniProtKB/TrEMBL	Q95NP8 Q95SX2 Q95U97 Q95U98 Q95U99 Q95UA0 Q95UA1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
	Reporter constructs were used to show that expression of AttA is bacterially induced. (Dushay et al., 2000)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0012042    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0012042 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of no expression detected. Peak expression observed in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0012042 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    10 embryo 16-18hr    13 embryo 18-20hr    61 embryo 20-22hr    38 embryo 22-24hr    59 larva L1    93 larva L2    32 larva L3 12hr old    796 larva L3 puffstage 1-2    2394 larva L3 puffstage 3-6    2778 larva L3 puffstage 7-9    1456 white prepupae new    2433 white prepupae 12hr    7663 white prepupae 24hr    5164 pupae 2d postWPP    2264 pupae 3d postWPP    491 pupae 4d postWPP    601 adult male 01day    1112 adult male 05day    588 adult male 30day    3709 adult female 01day    6762 adult female 05day    2940 adult female 30day    12899 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    10 embryo 16-18hr    13 embryo 18-20hr    61 embryo 20-22hr    38 embryo 22-24hr    59 larva L1    93 larva L2    32 larva L3 12hr old  (796) larva L3 puffstage 1-2  (2394) larva L3 puffstage 3-6  (2778) larva L3 puffstage 7-9  (1456) white prepupae new  (2433) white prepupae 12hr  (7663) white prepupae 24hr  (5164) pupae 2d postWPP  (2264) pupae 3d postWPP  (491) pupae 4d postWPP  (601) adult male 01day  (1112) adult male 05day  (588) adult male 30day  (3709) adult female 01day  (6762) adult female 05day  (2940) adult female 30day  (12899) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    10 embryo 16-18hr    13 embryo 18-20hr    61 embryo 20-22hr    38 embryo 22-24hr    59 larva L1    93 larva L2    32 larva L3 12hr old    796 larva L3 puffstage 1-2  (2394) larva L3 puffstage 3-6  (2778) larva L3 puffstage 7-9  1456 white prepupae new  (2433) white prepupae 12hr  (7663) white prepupae 24hr  (5164) pupae 2d postWPP  (2264) pupae 3d postWPP    491 pupae 4d postWPP    601 adult male 01day    1112 adult male 05day    588 adult male 30day  (3709) adult female 01day  (6762) adult female 05day  (2940) adult female 30day  (12899) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    10 embryo 16-18hr    13 embryo 18-20hr    61 embryo 20-22hr    38 embryo 22-24hr    59 larva L1    93 larva L2    32 larva L3 12hr old    796 larva L3 puffstage 1-2    2394 larva L3 puffstage 3-6    2778 larva L3 puffstage 7-9    1456 white prepupae new    2433 white prepupae 12hr    7663 white prepupae 24hr    5164 pupae 2d postWPP    2264 pupae 3d postWPP    491 pupae 4d postWPP    601 adult male 01day    1112 adult male 05day    588 adult male 30day    3709 adult female 01day    6762 adult female 05day    2940 adult female 30day  (12899) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    10 embryo 16-18hr    13 embryo 18-20hr    61 embryo 20-22hr    38 embryo 22-24hr    59 larva L1    93 larva L2    32 larva L3 12hr old    796 larva L3 puffstage 1-2    2394 larva L3 puffstage 3-6    2778 larva L3 puffstage 7-9    1456 white prepupae new    2433 white prepupae 12hr    7663 white prepupae 24hr    5164 pupae 2d postWPP    2264 pupae 3d postWPP    491 pupae 4d postWPP    601 adult male 01day    1112 adult male 05day    588 adult male 30day    3709 adult female 01day    6762 adult female 05day    2940 adult female 30day    12899 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0012042 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    10 embryo 16-18hr    13 embryo 18-20hr    61 embryo 20-22hr    38 embryo 22-24hr    59 larva L1    93 larva L2    32 larva L3 12hr old    796 larva L3 puffstage 1-2    2394 larva L3 puffstage 3-6    2778 larva L3 puffstage 7-9    1456 white prepupae new    2433 white prepupae 12hr    7663 white prepupae 24hr    5164 pupae 2d postWPP    2264 pupae 3d postWPP    491 pupae 4d postWPP    601 adult male 01day    1112 adult male 05day    588 adult male 30day    3709 adult female 01day    6762 adult female 05day    2940 adult female 30day    12899 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    10 embryo 16-18hr    13 embryo 18-20hr    61 embryo 20-22hr    38 embryo 22-24hr    59 larva L1    93 larva L2    32 larva L3 12hr old  (796) larva L3 puffstage 1-2  (2394) larva L3 puffstage 3-6  (2778) larva L3 puffstage 7-9  (1456) white prepupae new  (2433) white prepupae 12hr  (7663) white prepupae 24hr  (5164) pupae 2d postWPP  (2264) pupae 3d postWPP  (491) pupae 4d postWPP  (601) adult male 01day  (1112) adult male 05day  (588) adult male 30day  (3709) adult female 01day  (6762) adult female 05day  (2940) adult female 30day  (12899) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    10 embryo 16-18hr    13 embryo 18-20hr    61 embryo 20-22hr    38 embryo 22-24hr    59 larva L1    93 larva L2    32 larva L3 12hr old    796 larva L3 puffstage 1-2  2394 larva L3 puffstage 3-6  (2778) larva L3 puffstage 7-9  1456 white prepupae new  2433 white prepupae 12hr  (7663) white prepupae 24hr  (5164) pupae 2d postWPP  2264 pupae 3d postWPP    491 pupae 4d postWPP    601 adult male 01day    1112 adult male 05day    588 adult male 30day  (3709) adult female 01day  (6762) adult female 05day  (2940) adult female 30day  (12899) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    10 embryo 16-18hr    13 embryo 18-20hr    61 embryo 20-22hr    38 embryo 22-24hr    59 larva L1    93 larva L2    32 larva L3 12hr old    796 larva L3 puffstage 1-2    2394 larva L3 puffstage 3-6    2778 larva L3 puffstage 7-9    1456 white prepupae new    2433 white prepupae 12hr    7663 white prepupae 24hr    5164 pupae 2d postWPP    2264 pupae 3d postWPP    491 pupae 4d postWPP    601 adult male 01day    1112 adult male 05day    588 adult male 30day    3709 adult female 01day    6762 adult female 05day    2940 adult female 30day  12899 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    3 embryo 04-06hr    0 embryo 06-08hr    3 embryo 08-10hr    2 embryo 10-12hr    2 embryo 12-14hr    7 embryo 14-16hr    10 embryo 16-18hr    13 embryo 18-20hr    61 embryo 20-22hr    38 embryo 22-24hr    59 larva L1    93 larva L2    32 larva L3 12hr old    796 larva L3 puffstage 1-2    2394 larva L3 puffstage 3-6    2778 larva L3 puffstage 7-9    1456 white prepupae new    2433 white prepupae 12hr    7663 white prepupae 24hr    5164 pupae 2d postWPP    2264 pupae 3d postWPP    491 pupae 4d postWPP    601 adult male 01day    1112 adult male 05day    588 adult male 30day    3709 adult female 01day    6762 adult female 05day    2940 adult female 30day    12899 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0012042    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0012042 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: virgin spermatheca. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval fat body, inseminated spermatheca. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0012042 expression level Tissue   Expression Level Larval Central Nervous System    3.25 Larval Midgut no informative data Larval Hindgut    16.1 Larval Malpighian Tubules    6 Larval Fat Body    132.2 Larval Salivary Gland no informative data Larval Trachea    22.675 Larval Carcass    66.85 Adult Head    298.9 Adult Eye    55.2 Adult Brain    20 Adult Thoracic-Abdominal Ganglion    8.7 Adult Crop no informative data Adult Midgut    21.9 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    82.9 Adult Salivary Gland    2.2 Adult Heart no informative data Adult VirginFemale Spermatheca    556.5 Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    23.9 Adult Testis    2.6 Adult Male Accessory Gland    6.6 Adult Carcass    61.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.25 Larval Midgut no informative data Larval Hindgut    16.1 Larval Malpighian Tubules    6 Larval Fat Body    132.2 Larval Salivary Gland no informative data Larval Trachea    22.675 Larval Carcass    66.85 Adult Head    298.9 Adult Eye    55.2 Adult Brain    20 Adult Thoracic-Abdominal Ganglion    8.7 Adult Crop no informative data Adult Midgut    21.9 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    82.9 Adult Salivary Gland    2.2 Adult Heart no informative data Adult VirginFemale Spermatheca  (556.5) Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    23.9 Adult Testis    2.6 Adult Male Accessory Gland    6.6 Adult Carcass    61.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.25 Larval Midgut no informative data Larval Hindgut    16.1 Larval Malpighian Tubules    6 Larval Fat Body    132.2 Larval Salivary Gland no informative data Larval Trachea    22.675 Larval Carcass    66.85 Adult Head    298.9 Adult Eye    55.2 Adult Brain    20 Adult Thoracic-Abdominal Ganglion    8.7 Adult Crop no informative data Adult Midgut    21.9 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    82.9 Adult Salivary Gland    2.2 Adult Heart no informative data Adult VirginFemale Spermatheca    556.5 Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    23.9 Adult Testis    2.6 Adult Male Accessory Gland    6.6 Adult Carcass    61.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.25 Larval Midgut no informative data Larval Hindgut    16.1 Larval Malpighian Tubules    6 Larval Fat Body    132.2 Larval Salivary Gland no informative data Larval Trachea    22.675 Larval Carcass    66.85 Adult Head    298.9 Adult Eye    55.2 Adult Brain    20 Adult Thoracic-Abdominal Ganglion    8.7 Adult Crop no informative data Adult Midgut    21.9 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    82.9 Adult Salivary Gland    2.2 Adult Heart no informative data Adult VirginFemale Spermatheca    556.5 Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    23.9 Adult Testis    2.6 Adult Male Accessory Gland    6.6 Adult Carcass    61.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0012042 expression level Tissue   Expression Level Larval Central Nervous System    3.25 Larval Midgut no informative data Larval Hindgut    16.1 Larval Malpighian Tubules    6 Larval Fat Body    132.2 Larval Salivary Gland no informative data Larval Trachea    22.675 Larval Carcass    66.85 Adult Head    298.9 Adult Eye    55.2 Adult Brain    20 Adult Thoracic-Abdominal Ganglion    8.7 Adult Crop no informative data Adult Midgut    21.9 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    82.9 Adult Salivary Gland    2.2 Adult Heart no informative data Adult VirginFemale Spermatheca    556.5 Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    23.9 Adult Testis    2.6 Adult Male Accessory Gland    6.6 Adult Carcass    61.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    3.25 Larval Midgut no informative data Larval Hindgut    16.1 Larval Malpighian Tubules    6 Larval Fat Body    132.2 Larval Salivary Gland no informative data Larval Trachea    22.675 Larval Carcass    66.85 Adult Head    298.9 Adult Eye    55.2 Adult Brain    20 Adult Thoracic-Abdominal Ganglion    8.7 Adult Crop no informative data Adult Midgut    21.9 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    82.9 Adult Salivary Gland    2.2 Adult Heart no informative data Adult VirginFemale Spermatheca  556.5 Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    23.9 Adult Testis    2.6 Adult Male Accessory Gland    6.6 Adult Carcass    61.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    3.25 Larval Midgut no informative data Larval Hindgut    16.1 Larval Malpighian Tubules    6 Larval Fat Body    132.2 Larval Salivary Gland no informative data Larval Trachea    22.675 Larval Carcass    66.85 Adult Head    298.9 Adult Eye    55.2 Adult Brain    20 Adult Thoracic-Abdominal Ganglion    8.7 Adult Crop no informative data Adult Midgut    21.9 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    82.9 Adult Salivary Gland    2.2 Adult Heart no informative data Adult VirginFemale Spermatheca    556.5 Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    23.9 Adult Testis    2.6 Adult Male Accessory Gland    6.6 Adult Carcass    61.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    3.25 Larval Midgut no informative data Larval Hindgut    16.1 Larval Malpighian Tubules    6 Larval Fat Body    132.2 Larval Salivary Gland no informative data Larval Trachea    22.675 Larval Carcass    66.85 Adult Head    298.9 Adult Eye    55.2 Adult Brain    20 Adult Thoracic-Abdominal Ganglion    8.7 Adult Crop no informative data Adult Midgut    21.9 Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    82.9 Adult Salivary Gland    2.2 Adult Heart no informative data Adult VirginFemale Spermatheca    556.5 Adult InseminatedFemale Spermatheca    120.6 Adult Ovary    23.9 Adult Testis    2.6 Adult Male Accessory Gland    6.6 Adult Carcass    61.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland     Adult Heart no informative data Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    298.9   NA  Eye    55.2   NA  Brain    20   3.25  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    8.7   NA  Crop    no informative data   no informative data  Midgut    21.9   16.1  Hindgut    no informative data   6  Malpighian Tubules    no informative data   132.2  Fat Body    82.9   no informative data  Salivary Gland    2.2   NA  Heart    no informative data   22.675  Trachea    NA   NA  VirginFemale Spermatheca    556.5   NA  InseminatedFemale Spermatheca    120.6   NA  Ovary    23.9   NA  Testis    2.6   NA  Male Accessory Gland    6.6   66.85  Carcass    61.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_04
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0012042 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10146-RA;CG18372-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 AttAGD1649 viable, with Scer\GAL4da.G32 AttAScer\UAS.cTa Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of AttA Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of AttA Class Mutagen Stocks Known lesion AttAGD1649 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes AttAScer\UAS.cTa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6284 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1255} NA P{GD1649} NA P{GD17307} NA P{UAS-AttA.T} NA reporter construct P{AttA-lacZ.497} No P{AttA-lacZ.780} No
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antibacterial humoral response inferred from expression pattern (Lemaitre et al., 1997) defense response to Gram-negative bacterium inferred from expression pattern (Lemaitre et al., 1997) defense response to Gram-positive bacterium inferred from expression pattern (Gordon et al., 2008) humoral immune response inferred from expression pattern (Verleyen et al., 2006)
Cellular Component
CV term Evidence References
extracellular space inferred from direct assay (Liu et al., 2006, Verleyen et al., 2006)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
antibacterial humoral response non-traceable author statement (Swiss-Prot Project Members, 1995.9.1) defense response to bacterium traceable author statement (Meister et al., 2000) defense response to Gram-negative bacterium non-traceable author statement (Dushay et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions AttA allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0012042 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36636
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dmau\AttA (Lazzaro and Clark, 2001) Dpse\GA10109   Dsec\AttA (Lazzaro and Clark, 2001) Dsim\AttA (Lazzaro and Clark, 2001) Dyak\AttA
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003389-PA Aedes aegypti (mosquito) BGIBMGA002739-PA Bombyx mori (silk worm) BGIBMGA002747-PA Bombyx mori (silk worm) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0231267 FBgn0068530 FBgn0207710 FBgn0207711 FBgn0046918 FBgn0046917 FBgn0176447 FBgn0248589 FBgn0070168 FBgn0160872 FBgn0143571 FBgn0142818 FBgn0041581 FBgn0128215 FBgn0112667 FBgn0112666 FBgn0088379 ATT
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v9288 w1118 P{GD1649}v9288 v9287 w1118; P{GD1649}v9287
Genomic Clones ( 2 )
	BACR03K23 BACR07P02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 19 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH04030 LP05763
Other clones	DPiM_GH04030
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	473712 523276 557867 558169 Dmel_dig_010647_0647_1200 EN00561 EN03744 EN05501 EN06601 EN12545 EN13128 EN14706 EN15304 EN16036 EN17442 ESG0118a.B21_D09
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0012042 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36636
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: AttA anon-WO0140519.5 (FlyBase, 1996-) Source for merge of: AttA BcDNA:LP05763 (BDGP Project Members, 2000-)
Additional comments	Source for merge of AttA anon-WO0140519.5 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background. (McDonald and Rosbash, 2001) Ecol\lacZDpt.PR adults are pricked with a sterile needle dipped in culture pellets of various living microorganisms (distinct bacterial strains, fungal spores or hyphae). Pricking results in a low but clearly detectable expression of all antimicrobial genes and these genes are induced above the background level by specific classes of microorganism. (Lemaitre et al., 1997) Genes encoding antibacterial peptides are regulated in a manner distinct from that of Drs, encoding the antifungal peptide. (Lemaitre et al., 1996) Differential display can be applied to a whole organism to identify induced immune genes, the technique has been used to isolate and characterise AttA. (Asling et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079021 RefSeq (Proteins) • NP_523745 DDBJ / EMBL / GenBank • AAF58215 AAF70455 AAL23641 AAL23642 AAL23643 AAL23644 AAL23645 AAL23646 AAL23647 AAL23648 AAL23649 AAL23650 AAL23651 AAL25487 AAO24989 AC007580 AF220544 AI257408 AW944054 AX154656 AY056855 AY056856 AY056857 AY056858 AY056859 AY056860 AY056861 AY056862 AY056863 AY056864 AY056865 AY056866 AY056891 AY056892 AY056893 AY056894 AY056895 AY056896 AY056897 AY056898 AY056899 AY056900 AY056901 AY056902 AY060448 CAA86995 Z46893 Entrez Gene - A searchable database of RefSeq genes. • 36636 UniProtKB/Swiss-Prot • P45884 UniProtKB/TrEMBL • Q95NP8 Q95SX2 Q95U97 Q95U98 Q95U99 Q95UA0 Q95UA1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Attacin, N-terminal (IPR005520) Attacin, C-terminal (IPR005521)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0012042 DRSC - Results from RNAi screens. • FBgn0012042 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0012042 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10146-RA;CG18372-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0012042 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36636 InParanoid A subset of ortholog calls from InParanoid. • AAEL003389-PA Aedes aegypti (mosquito) BGIBMGA002739-PA Bombyx mori (silk worm) BGIBMGA002747-PA Bombyx mori (silk worm) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36636 modMine - Data generated by the modENCODE project. • FBgn0012042 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0231267 FBgn0068530 FBgn0207710 FBgn0207711 FBgn0046918 FBgn0046917 FBgn0176447 FBgn0248589 FBgn0070168 FBgn0160872 FBgn0143571 FBgn0142818 FBgn0041581 FBgn0128215 FBgn0112667 FBgn0112666 FBgn0088379 ATT REDfly - A database of transcriptional regulatory elements. • FBgn0012042
Synonyms & Secondary IDs ( 20 )
Reported As
Symbol Synonym	anon-WO0140519.5   att (Guntermann et al., 2009, De Gregorio et al., 2002, Leulier et al., 2000, Williams et al., 1997, Georgel et al., 2001, Fedorka et al., 2007) Att (Zambon et al., 2005, Takehana et al., 2002, Gottar et al., 2002, Lemaitre et al., 1997, Lemaitre et al., 1996, Ryu et al., 2008, Bergeret et al., 2008, Ren et al., 2007, Aggarwal et al., 2008) ATT (Tzou et al., 2000) AttA (Sackton and Clark, 2009, Kocks et al., 2005, Ramos et al., 2006, Chen et al., 2010, Zraly et al., 2006, Kleino et al., 2008, Waterhouse et al., 2007, Domazet-Loso and Tautz, 2003, Lazzaro et al., 2004, Leulier et al., 2006, Busse et al., 2007, Feng et al., 2009, Buchon et al., 2009, Wigby et al., 2008, Carrera et al., 2008, Kapelnikov et al., 2008, Thoetkiattikul et al., 2005, Greene et al., 2005, Tauszig-Delamasure et al., 2002, Kim et al., 2005, Clark et al., 2011, Wertheim et al., 2005, Becker et al., 2010, Huang et al., 2010, Curtis et al., 2007, Valanne et al., 2010, Chen et al., 2010, Radyuk et al., 2010, Domanitskaya et al., 2007, Gerbasi et al., 2011, Seong et al., 2011, Gordon et al., 2008, Thevenon et al., 2009, Kim et al., 2010) attA (Boutros et al., 2002, Wu et al., 2001, Lee and Edery, 2008, Winterhalter and Fedorka, 2009, Gesellchen et al., 2005, Tsuda et al., 2005, Marshall and Sinclair, 2010) Att A (Tzou et al., 2002, Dijkers and O'Farrell, 2007) att A (Lemaitre, 2000.12.20, Zsindely et al., 2009) BcDNA:LP05763   CG10146 (Irving et al., 2001, De Gregorio et al., 2001, Wang et al., 2006, Liu et al., 2006, Winterhalter and Fedorka, 2009, Carrera et al., 2008, Verleyen et al., 2006, Marshall and Sinclair, 2010, Hernandez-Romano et al., 2008, Wertheim et al., 2005, Douglas et al., 2011)
Name Synonym	attacin (Okado et al., 2009, Guntermann et al., 2009, Delaney et al., 2005, Steiner, 2004, Leclerc and Reichhart, 2004, Mellroth et al., 2003, Cooper et al., 2002, Delaney and Anderson, 2002, Delaney and Anderson, 2001, Aderem and Ulevitch, 2000, Meister et al., 2000, Basset et al., 2000, Dushay et al., 1998, Park et al., 2004, Georgel et al., 2001, Zelinger and Heifetz, 2006, Delaney et al., 2006, Avet-Rochex et al., 2005, Brennan et al., 2007, Fedorka et al., 2007, Lee and Edery, 2008, Persson et al., 2007, Bhattacharya and Steward, 2002, Marshall and Sinclair, 2010, Tauszig-Delamasure et al., 2002) Attacin (Brennan and Anderson, 2004, Kurz and Ewbank, 2003, Kimbrell and Beutler, 2001, Vidal et al., 2001, Rutschmann et al., 2000, Silverman et al., 2000, Barillas-Mury et al., 2000, Martin-Blanco, 2000, Elrod-Erickson et al., 2000, Govind, 1999, Hultmark, 1994.12.5, Han et al., 1998, Mathey-Prevot and Perrimon, 1998, Hoffmann and Reichhart, 1997, Silverman et al., 2003, Tanji et al., 2006, Zhou et al., 2005, Rutschmann et al., 2000, Huh et al., 2007, Avila et al., 2002, Goto et al., 2008, Bergeret et al., 2008, Dijkers and O'Farrell, 2007, Wu et al., 2007, Yajima et al., 2003, Ertürk-Hasdemir et al., 2009, Ayres and Schneider, 2009, Aggarwal et al., 2008, Costa et al., 2009, Ooi et al., 2002, Libert et al., 2006, Zhao et al., 2010, Tanji et al., 2010, Akbar et al., 2011) attacin A (Mukae et al., 2002, Fedorka et al., 2007, Feng et al., 2009, Lauwers et al., 2009, Tsuda et al., 2005, Radyuk et al., 2010, Douglas et al., 2011) Attacin A (Lazzaro and Clark, 2001, Tzou et al., 2002, Wang et al., 2006, Kim and Lis, 2005, Lazzaro et al., 2006, Kleino et al., 2008, Lai et al., 2007, Lazzaro et al., 2004, Busse et al., 2007, Tang et al., 2008, Dijkers and O'Farrell, 2007, Wiklund et al., 2009, Roxstrom-Lindquist et al., 2004, Verleyen et al., 2006, Beckstead et al., 2005, Xi et al., 2008, Huang et al., 2010, Clark et al., 2011, Wang et al., 2011, Gordon et al., 2008, Kim et al., 2010) Attacin-A (Sano et al., 2005, Leulier et al., 2006, Kim et al., 2007, McGraw et al., 2008, Charroux and Royet, 2009, Carpenter et al., 2009, Kim et al., 2005, Morozova et al., 2007, Becker et al., 2010, Lemos et al., 2010, Johansson et al., 2005) AttacinA (Tanji et al., 2007, Ligoxygakis et al., 2002, Tanji et al., 2010, Valanne et al., 2010) attacinA (Hallem et al., 2007, Gesellchen et al., 2005) attacin-A (Domanitskaya et al., 2007) Attacin-A precursor (Hernandez-Romano et al., 2008) Attackin (Pletcher et al., 2002)
Secondary FlyBase IDs
	FBgn0044580 FBgn0064916
References ( 202 )
Generate a list of	All references relating to this gene ( 202 )
List References by type	Research paper  ( 146 ) Supplementary material  ( 5 ) Review  ( 23 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 13 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 1 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Patent  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 17 )
	Akbar et al., 2011, J. Cell Biol. 192(3): 383--390 The full-of-bacteria gene is required for phagosome maturation during immune defense in Drosophila. [FBrf0212933] Clark et al., 2011, Curr. Biol. 21(19): 1672--1677 Multiple TGF-β Superfamily Signals Modulate the Adult Drosophila Immune Response. [FBrf0216429] Douglas et al., 2011, Proc. Biol. Sci. 278(1704): 333--338 How the insect immune system interacts with an obligate symbiotic bacterium. [FBrf0212672] Gerbasi et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(8): 3204--3209 Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis. [FBrf0213185] Rao et al., 2011, Insect Biochem. Mol. Biol. 41(12): 982--992 Manduca sexta moricin promoter elements can increase promoter activities of Drosophila melanogaster antimicrobial peptide genes. [FBrf0216595] Seong et al., 2011, Biogerontology 12(2): 93--107 Genome-wide analysis of low-dose irradiated male Drosophila melanogaster with extended longevity. [FBrf0213307] Wang et al., 2011, Dev. Comp. Immunol. 35(1): 105--114 Litopenaeus vannamei tumor necrosis factor receptor-associated factor 6 (TRAF6) responds to Vibrio alginolyticus and white spot syndrome virus (WSSV) infection and activates antimicrobial peptide genes. [FBrf0212046] Becker et al., 2010, Nature 463(7279): 369--373 FOXO-dependent regulation of innate immune homeostasis. [FBrf0209804] Chen et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(48): 20774--20779 Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi. [FBrf0212390] Huang et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(18): 8322--8327 Endocytic pathway is required for Drosophila Toll innate immune signaling. [FBrf0210737] Kim et al., 2010, Exp. Gerontol. 45(12): 984--987 Enhancement of stress resistances and downregulation of Imd pathway by lower developmental temperature in Drosophila melanogaster. [FBrf0212401] Lemos et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(36): 15826--15831 Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict. [FBrf0211775] Marshall and Sinclair, 2010, Proc. Biol. Sci. 277(1683): 963--969 Repeated stress exposure results in a survival-reproduction trade-off in Drosophila melanogaster. [FBrf0209895] Radyuk et al., 2010, Biochim. biophys. Acta 1800(11): 1153--1163 Peroxiredoxin 5 modulates immune response in Drosophila. [FBrf0211669] Tanji et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(33): 14715--14720 Heterodimers of NF-{kappa}B transcription factors DIF and Relish regulate antimicrobial peptide genes in Drosophila. [FBrf0211616] Valanne et al., 2010, J. Immunol. 184(11): 6188--6198 Genome-wide RNA interference in Drosophila cells identifies G protein-coupled receptor kinase 2 as a conserved regulator of NF-kappaB signaling. [FBrf0210846] Zhao et al., 2010, PLoS ONE 5(7): e11701 Experimental selection for Drosophila survival in extremely high o(2) environments. [FBrf0211379] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...