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Gene Dmel\Dh44

General Information
Symbol	Dmel\Dh44	Species	D. melanogaster
Name	Diuretic hormone 44	Annotation symbol	CG8348
Feature type	protein_coding_gene	FlyBase ID	FBgn0012344
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	DH, DH44
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	85E2-85E2	Sequence location	3R:5,463,904..5,476,428 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Diuretic hormone 44 is referred to in FlyBase by the symbol Dmel\Dh44 (CG8348, FBgn0012344). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: neuropeptide hormone activity. There is experimental evidence that it is involved in the biological process: body fluid secretion. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Corticotropin-releasing factor conserved site; Corticotropin-releasing factor, CRF. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult brain. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1634957_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Dh. Gene sequence location is 3R:5463904..5476428.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85E2-85E2   Limits computationally determined from genome sequence between P{EP}CrcEP3006 and P{lacW}s2681
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dh44 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dh44-RA FBtr0082080  NM_141665   1412   356 Dh44-RB FBtr0112870  NM_001104255   2255   423
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dh44-PA   FBpp0081558   39.1   356   8.44     NP_649922   AAF54421 Dh44-PB   FBpp0111783   46.5   423   9.59     NP_001097725   ABW08627
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Corticotropin-releasing factor conserved site (IPR018446) Corticotropin-releasing factor, CRF (IPR000187)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA699224   AE014297 AAF54421   AE014297 ABW08627   AI514143   AY113257 AAM29262   BF499889   BG633448   CO279998   CO308404   EC215053   EC231031
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VH98 A8JQW2 Q8MZC1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult brain. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    231.15 Larval Midgut    17.8 Larval Hindgut    14.4 Larval Malpighian Tubules    64.8 Larval Fat Body    15 Larval Salivary Gland    3.5 Larval Trachea    2.625 Larval Carcass    7.075 Adult Head    174.1 Adult Eye    7.55 Adult Brain    654.7 Adult Thoracic-Abdominal Ganglion    124.2 Adult Crop    5.4 Adult Midgut    8.4 Adult Hindgut    4 Adult Malpighian Tubules    15.7 Adult Fat Body    9.3 Adult Salivary Gland    12.3 Adult Heart    0.9 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    1.1 Adult Testis    77 Adult Male Accessory Gland    6.6 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    231.15 Larval Midgut    17.8 Larval Hindgut    14.4 Larval Malpighian Tubules    64.8 Larval Fat Body    15 Larval Salivary Gland    3.5 Larval Trachea    2.625 Larval Carcass    7.075 Adult Head    174.1 Adult Eye    7.55 Adult Brain  (654.7) Adult Thoracic-Abdominal Ganglion    124.2 Adult Crop    5.4 Adult Midgut    8.4 Adult Hindgut    4 Adult Malpighian Tubules    15.7 Adult Fat Body    9.3 Adult Salivary Gland    12.3 Adult Heart    0.9 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    1.1 Adult Testis    77 Adult Male Accessory Gland    6.6 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    231.15 Larval Midgut    17.8 Larval Hindgut    14.4 Larval Malpighian Tubules    64.8 Larval Fat Body    15 Larval Salivary Gland    3.5 Larval Trachea    2.625 Larval Carcass    7.075 Adult Head    174.1 Adult Eye    7.55 Adult Brain    654.7 Adult Thoracic-Abdominal Ganglion    124.2 Adult Crop    5.4 Adult Midgut    8.4 Adult Hindgut    4 Adult Malpighian Tubules    15.7 Adult Fat Body    9.3 Adult Salivary Gland    12.3 Adult Heart    0.9 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    1.1 Adult Testis    77 Adult Male Accessory Gland    6.6 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    231.15 Larval Midgut    17.8 Larval Hindgut    14.4 Larval Malpighian Tubules    64.8 Larval Fat Body    15 Larval Salivary Gland    3.5 Larval Trachea    2.625 Larval Carcass    7.075 Adult Head    174.1 Adult Eye    7.55 Adult Brain    654.7 Adult Thoracic-Abdominal Ganglion    124.2 Adult Crop    5.4 Adult Midgut    8.4 Adult Hindgut    4 Adult Malpighian Tubules    15.7 Adult Fat Body    9.3 Adult Salivary Gland    12.3 Adult Heart    0.9 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    1.1 Adult Testis    77 Adult Male Accessory Gland    6.6 Adult Carcass    4 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    231.15 Larval Midgut    17.8 Larval Hindgut    14.4 Larval Malpighian Tubules    64.8 Larval Fat Body    15 Larval Salivary Gland    3.5 Larval Trachea    2.625 Larval Carcass    7.075 Adult Head    174.1 Adult Eye    7.55 Adult Brain    654.7 Adult Thoracic-Abdominal Ganglion    124.2 Adult Crop    5.4 Adult Midgut    8.4 Adult Hindgut    4 Adult Malpighian Tubules    15.7 Adult Fat Body    9.3 Adult Salivary Gland    12.3 Adult Heart    0.9 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    1.1 Adult Testis    77 Adult Male Accessory Gland    6.6 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    231.15 Larval Midgut    17.8 Larval Hindgut    14.4 Larval Malpighian Tubules    64.8 Larval Fat Body    15 Larval Salivary Gland    3.5 Larval Trachea    2.625 Larval Carcass    7.075 Adult Head    174.1 Adult Eye    7.55 Adult Brain  654.7 Adult Thoracic-Abdominal Ganglion    124.2 Adult Crop    5.4 Adult Midgut    8.4 Adult Hindgut    4 Adult Malpighian Tubules    15.7 Adult Fat Body    9.3 Adult Salivary Gland    12.3 Adult Heart    0.9 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    1.1 Adult Testis    77 Adult Male Accessory Gland    6.6 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    231.15 Larval Midgut    17.8 Larval Hindgut    14.4 Larval Malpighian Tubules    64.8 Larval Fat Body    15 Larval Salivary Gland    3.5 Larval Trachea    2.625 Larval Carcass    7.075 Adult Head    174.1 Adult Eye    7.55 Adult Brain    654.7 Adult Thoracic-Abdominal Ganglion    124.2 Adult Crop    5.4 Adult Midgut    8.4 Adult Hindgut    4 Adult Malpighian Tubules    15.7 Adult Fat Body    9.3 Adult Salivary Gland    12.3 Adult Heart    0.9 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    1.1 Adult Testis    77 Adult Male Accessory Gland    6.6 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    231.15 Larval Midgut    17.8 Larval Hindgut    14.4 Larval Malpighian Tubules    64.8 Larval Fat Body    15 Larval Salivary Gland    3.5 Larval Trachea    2.625 Larval Carcass    7.075 Adult Head    174.1 Adult Eye    7.55 Adult Brain    654.7 Adult Thoracic-Abdominal Ganglion    124.2 Adult Crop    5.4 Adult Midgut    8.4 Adult Hindgut    4 Adult Malpighian Tubules    15.7 Adult Fat Body    9.3 Adult Salivary Gland    12.3 Adult Heart    0.9 Adult VirginFemale Spermatheca    6.6 Adult InseminatedFemale Spermatheca    9.8 Adult Ovary    1.1 Adult Testis    77 Adult Male Accessory Gland    6.6 Adult Carcass    4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    174.1   NA  Eye    7.55   NA  Brain    654.7   231.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    124.2   NA  Crop    5.4   no informative data  Midgut    8.4   14.4  Hindgut    4   64.8  Malpighian Tubules    no informative data   no informative data  Fat Body    9.3   3.5  Salivary Gland    no informative data   NA  Heart    0.9   2.625  Trachea    NA   NA  VirginFemale Spermatheca    6.6   NA  InseminatedFemale Spermatheca    9.8   NA  Ovary    1.1   NA  Testis    77   NA  Male Accessory Gland    6.6   7.075  Carcass    4 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    23 central nervous system, pupae P8    9 head, virgin 1-day female    18 head, virgin 4-day female    24 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    12 head, mated 1-day male    28 head, mated 4-day male    34 head, mated 20-day male    41 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    23 central nervous system, pupae P8    9 head, virgin 1-day female    18 head, virgin 4-day female    24 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    12 head, mated 1-day male  (28) head, mated 4-day male  (34) head, mated 20-day male  (41) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    23 central nervous system, pupae P8    9 head, virgin 1-day female    18 head, virgin 4-day female    24 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    12 head, mated 1-day male    28 head, mated 4-day male    34 head, mated 20-day male    41 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    23 central nervous system, pupae P8    9 head, virgin 1-day female    18 head, virgin 4-day female    24 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    12 head, mated 1-day male    28 head, mated 4-day male    34 head, mated 20-day male    41 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    23 central nervous system, pupae P8    9 head, virgin 1-day female    18 head, virgin 4-day female    24 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    12 head, mated 1-day male    28 head, mated 4-day male    34 head, mated 20-day male    41 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    23 central nervous system, pupae P8    9 head, virgin 1-day female    18 head, virgin 4-day female    24 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    12 head, mated 1-day male  28 head, mated 4-day male  (34) head, mated 20-day male  (41) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    23 central nervous system, pupae P8    9 head, virgin 1-day female    18 head, virgin 4-day female    24 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    12 head, mated 1-day male    28 head, mated 4-day male    34 head, mated 20-day male    41 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    23 central nervous system, pupae P8    9 head, virgin 1-day female    18 head, virgin 4-day female    24 head, virgin 20-day female    17 head, mated 1-day female    19 head, mated 4-day female    24 head, mated 20-day female    12 head, mated 1-day male    28 head, mated 4-day male    34 head, mated 20-day male    41 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    0 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    0 carcass, larvae L3 wandering    4 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    6 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of no expression detected. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    9 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    8 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    9 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    8 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    9 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    8 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    9 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    8 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    9 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    8 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    9 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    8 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    9 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    8 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    1 embryo 16-18hr    2 embryo 18-20hr    3 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    9 larva L2    4 larva L3 12hr old    2 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    3 white prepupae new    3 white prepupae 12hr    3 white prepupae 24hr    2 pupae 2d postWPP    3 pupae 3d postWPP    4 pupae 4d postWPP    3 adult male 01day    5 adult male 05day    8 adult male 30day    8 adult female 01day    2 adult female 05day    1 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    5 cold shock, 4-day adult    3 heat shock, 4-day adult    2 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    6 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    3 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    3 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_18 mE1_20_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0012344 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9881-RA;CG8348-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Dh44GD13897 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of Dh44 Class Mutagen Stocks Known lesion Dh44MB07006 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dh44 Class Mutagen Stocks Known lesion Dh44GD13897 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dh44JF01822 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dh44KK110160 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dh44NIG.8348R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6264 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.8348R} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}Dh44MB07006 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
body fluid secretion inferred from direct assay (Cabrero et al., 2002)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
diuretic hormone activity non-traceable author statement (Hewes and Taghert, 2001) hormone activity inferred from electronic annotation with InterPro:IPR000187 (FlyBase Curators et al., 2004-) neuropeptide hormone activity inferred from sequence or structural similarity (vanden Broeck, 2001)
Biological Process
CV term Evidence References
neuropeptide signaling pathway inferred from sequence or structural similarity (vanden Broeck, 2001)
Cellular Component
CV term Evidence References
extracellular region inferred from electronic annotation with InterPro:IPR000187 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dh44 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0012344
Orthologs
OrthoDB Orthologs (27) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6J3X3K Dipteran inclusive ortholog search EOG6SBF79 Insect inclusive ortholog search EOG6XD2NT Arthropod inclusive ortholog search EOG689346 Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6J3X3K)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Dh44     Drosophila simulans   Dsim\GD18635 Y   Drosophila sechellia   Dsec\GM23824 Y   Drosophila erecta   Dere\GG16993 Y   Drosophila yakuba   Dyak\GE25971 Y   Drosophila ananassae   Dana\GF16610 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA27488 Y   Drosophila persimilis   Dper\GL12380 Y   Drosophila willistoni   Dwil\GK11103 Y   Drosophila virilis   Dvir\GJ10898 Y   Drosophila mojavensis   Dmoj\GI24078 Y
Orthologs in non-Drosophila Dipterans (EOG6SBF79)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Anopheles gambiae Malaria mosquito  Agam\DH44
Orthologs in non-Dipteran Insects (EOG6XD2NT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB48796   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007802   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH24641   Atta cephalotes Leafcutter ant  Acep\ACEP19316   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13244   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL23574   Linepithema humile Argentine ant  Lhum\LH12147   Pogonomyrmex barbatus Red harvester ant  Pbar\PB21372   Solenopsis invicta Red fire ant  Sinv\SINV16263   Acyrthosiphon pisum Pea aphid  Apim\ACYPI34739   Bombyx mori Silkmoth  Bmor\BGIBMGA007762   Pediculus humanus Human body louse  Phum\PHUM075460   Tribolium castaneum Red flour beetle  Tcas\TC002243   Tribolium castaneum Red flour beetle  Tcas\DH47
Orthologs in non-Insect Arthropods (EOG689346)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Ixodes scapularis Deer tick  Isca\ISCW007845
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18635 Drosophila sechellia Dsec\GM23824 Drosophila erecta Dere\GG16993 Drosophila yakuba Dyak\GE25971 Drosophila ananassae Dana\GF16610 Drosophila pseudoobscura pseudoobscura Dpse\GA27488 Drosophila persimilis Dper\GL12380 Drosophila willistoni Dwil\GK11103 Drosophila virilis Dvir\GJ10898 Drosophila mojavensis Dmoj\GI24078 Drosophila grimshawi Dgri\GH18271
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	25345 w1118; Mi{ET1}Dh44MB07006 25804 y1 v1; P{TRiP.JF01822}attP2
VDRC	v108473 P{KK110160}VIE-260B v45054 w1118 P{GD13897}v45054
Genomic Clones ( 2 )
	BACR19N07 BACR30F01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT14664
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH27214 HL08001
Other clones	EK152208 EK257955
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0012344 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41170
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Dh44 Dh (FlyBase, 2009-)
Source for database merge of
Additional comments	FlyBase Curator comment: 'Dh' (FBgn0012344) renamed to 'Dh44' to reflect usage in the literature, to clearly distinguish it from 'Dh31' (FBgn0032048) and 'dh' (FBgn0014147), and for consistency with the nomenclature of 'Dh44-R1' (FBgn0033932) and the other diuretic hormone and diuretic hormone receptor genes. (FlyBase, 2009-)
Other Comments
	The putative Dh gene product was identified by cross-reactivity with an antibody raised against M.sexta neuropeptide diuretic hormone. (Zitnan et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_141665 NM_001104255 RefSeq (Proteins) • NP_649922 NP_001097725 DDBJ / EMBL / GenBank • AA699224 AAF54421 AAM29262 ABW08627 AI514143 AY113257 BF499889 BG633448 Entrez Gene - A searchable database of RefSeq genes. • 41170 UniProtKB/TrEMBL • A8JQW2 Q8MZC1 Q9VH98
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Corticotropin-releasing factor conserved site (IPR018446) Corticotropin-releasing factor, CRF (IPR000187)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0012344 DRSC - Results from RNAi screens. • FBgn0012344 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0012344 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9881-RA;CG8348-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0012344 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41170 modMine - Data generated by the modENCODE project. • FBgn0012344
Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym	CG8348 (Mount, 2001.8.14, Perkins et al., 1.15.2009, Keleman et al., 2009.8.5, Wegener and Gorbashov, 2008) DH (Johnson et al., 2004, Prokop, 1999) Dh (Wegener and Gorbashov, 2008, Dierick and Greenspan, 2006, Betz and Darnell, 2006, Japanese National Institute of Genetics, 2012.5.21) DH44 (Johnson et al., 2003, Birse et al., 2006, Johnson et al., 2005, Johnson et al., 2008, Veenstra et al., 2008, Bowser and Tobe, 2006) DH 44 (Park et al., 2008) Dh44   DH44 (Hector et al., 2009) Drm-DH (vanden Broeck, 2001) drome-DH44 (O'Donnell et al., 2003) Drome-DH44 (Cabrero et al., 2002)
Name Synonym	CRF-like peptide (Broderick et al., 2004, Cabrero et al., 2002) Diuretic hormone (Zitnan et al., 1993) diuretic hormone (Hewes and Taghert, 2001) diuretic hormone 44 (Johnson et al., 2004, Birse et al., 2006, Veenstra, 2009, Hector et al., 2009, Veenstra et al., 2008) Diuretic hormone 44 (Johnson et al., 2005, )
Secondary FlyBase IDs
	FBgn0037725
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 18 ) Supplementary material  ( 3 ) Review  ( 5 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 2 )
	Fontana and Crews, 2012, Dev. Biol. 372(1): 131--142 Transcriptome analysis of Drosophila CNS midline cells reveals diverse peptidergic properties and a role for castor in neuronal differentiation. [FBrf0219766] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...