Gene Dhyd\Adh2

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General Information

Symbol

Dhyd\Adh2

Species

D. hydei

Name

Alcohol dehydrogenase-2

Annotation symbol

Feature type

gene

FlyBase ID

FBgn0012359

Gene Model Status

Unannotated

Stock availability

None publicly available

Also Known As

Adh, Adh-2

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

Sequence location

Summary Information

Automatically generated summary

See sections below for more information

The gene Alcohol dehydrogenase-2 is referred to in FlyBase by the symbol Dhyd\Adh2 (FBgn0012359). It is a gene from Drosophila hydei. An electronic pipeline based on InterPro domains suggests that it has the molecular function: alcohol dehydrogenase (NAD) activity; nucleotide binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: oxidation-reduction process; alcohol metabolic process. No alleles are reported. It has no annotated transcripts. Protein features are: Alcohol dehydrogenase, Drosophila-type; Alcohol dehydrogenase, insect-type; NAD(P)-binding domain; Short-chain dehydrogenase/reductase SDR; Short-chain dehydrogenase/reductase, conserved site. Gene has not been localized to the genome sequence.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

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Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

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Short-chain dehydrogenase/reductase, conserved site (IPR020904)

Alcohol dehydrogenase, insect-type (IPR002424)

Alcohol dehydrogenase, Drosophila-type (IPR002425)

Short-chain dehydrogenase/reductase SDR (IPR002198)

NAD(P)-binding domain (IPR016040)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

X58694

CAA41539

UniProtKB/Swiss-Prot

P23237

UniProtKB/TrEMBL

Mapped Features

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

modENCODE Anatomy RNA-Seq

modENCODE Development RNA-Seq

modENCODE Cell Lines RNA-Seq

modENCODE Treatments RNA-Seq

Expression Clusters

External Data & Images

Linkouts

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Dhyd\Adh2	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Dhyd\Adh2	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 3 terms )

Molecular Function

CV term

Evidence

References

alcohol dehydrogenase (NAD) activity

inferred from electronic annotation with InterPro:IPR002424, InterPro:IPR002425

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

alcohol metabolic process

inferred from electronic annotation with InterPro:IPR002425

(FlyBase Curators et al., 2004-)

oxidation-reduction process

inferred from electronic annotation with InterPro:IPR002424, InterPro:IPR002425

(FlyBase Curators et al., 2004-)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Dhyd\Adh2 allele

Gene

References

External Data

Linkouts

Orthologs

OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

No orthologs identified

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

No orthologs identified

Arthropod inclusive ortholog search

No orthologs identified

Metazoa inclusive ortholog search

No orthologs identified

Ortholog(s) in Drosophila melanogaster (None identified)

No D. melanogaster orthologies identified

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (0) based on analysis using Dmel annotation version 4.3

No orthologs identified

Stocks & Reagents

Stocks Listed in FlyBase ( 0 )

Genomic Clones ( 0 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

The phylogenetic relationships and divergence times of 39 drosophilid species have been studied by using the coding region of the Adh gene.

(Russo et al., 1995)

Adh activity in 71 Drosophila species is assayed to determine if the protein plays a key role in the adaptation of species to substrates undergoing alcoholic fermentation.

(Mercot et al., 1994)

Phylogenetic DNA sequence comparison of ten Drosophila species has been used to elucidate the secondary structure of Adh mRNA. One possible pairing region in the 5' leader sequence and 22 in the coding and noncoding regions have been identified by seeking an equivalent pairing region in homologous RNA. Most are short range pairings such as hairpins. The rate of coevolution in noncoding pairing region is higher than in coding regions in accordance with selective constraints on substitution rates in coding region.

(Stephan and Kirby, 1993)

The organization of the Adh gene region in D.hydei is similar to that found in D.mulleri and D.mojavensis. There are three tandem Adh genes: 5' gene is the pseudogene, Dhyd\Adh2 and then the 3' gene Dhyd\Adh1. Deletion of a nucleotide in the second codon of each pseudogene suggests that the first duplication occurred before the divergence of the hydei and mulleri subgroups. Dhyd\Adh1 and Dhyd\Adh2 are more alike than Dmoj\Adh1 and Dmoj\Adh2. Comparisons of the extent of sequence divergence propose that independent duplication events generated Dhyd\Adh1 and Dhyd\Adh2 in the two lineages.

(Menotti-Raymond et al., 1991)

Structure and nucleotide sequence comparisons of Adh genes proposed that an intial duplication of an ancestral Adh gene generated two Adh genes arranged in tandem. The more 5' gene became a pseudogene while the more 3' gene remained functional through all the developmental stages. A second duplication of this 3' gene resulted in 3 genes: a pseudogene, Dhyd\Adh2 and Dhyd\Adh1.

(Yum et al., 1991)

A shift in third-codon-nucleotide frequency is seen when comparing species of the two subgenera Drosophila and Sophophora. These data suggests that the change in codon usage for Adh in the two subgenera is specific for Adh. The reason for the shift in codon usage is unknown.

(Starmer and Sullivan, 1989)

External Crossreferences & Linkouts

Sequence Crossreferences

DDBJ / EMBL / GenBank

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UniProtKB/Swiss-Prot

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