Gene Dsim\GstD1

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General Information

Symbol

Dsim\GstD1

Species

D. simulans

Name

Glutathione S transferase D1

Annotation symbol

GD20577

Feature type

protein_coding_gene

FlyBase ID

FBgn0012838

Gene Model Status

Current

Stock availability

None publicly available

Also Known As

GstD1

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

Sequence location

3R:13,194,426..13,195,055 [+]

Genomic Maps

Summary Information

Automatically generated summary

See sections below for more information

The gene Glutathione S transferase D1 is referred to in FlyBase by the symbol Dsim\GstD1 (GD20577, FBgn0012838). It is a protein_coding_gene from Drosophila simulans. There is experimental evidence that it has the molecular function: DDT-dehydrochlorinase activity. The biological processes in which it is involved are not known. No alleles are reported. It has one annotated transcript and one annotated polypeptide. Protein features are: Glutathione S-transferase, C-terminal; Glutathione S-transferase, C-terminal-like; Glutathione S-transferase, N-terminal; Glutathione S-transferase/chloride channel, C-terminal; Thioredoxin-like fold. Gene sequence location is 3R:13194426..13195055.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dsim\GstD1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Dsim\GstD1-RA

FBtr0220487

XM_002103697

630

209

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Dsim\GstD1-PA

FBpp0218979

23.8

209

6.53

XP_002103733

EDX13236

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Glutathione S-transferase, N-terminal (IPR004045)

Glutathione S-transferase, C-terminal (IPR004046)

Glutathione S-transferase, C-terminal-like (IPR010987)

Thioredoxin-like fold (IPR012336)

Glutathione S-transferase/chloride channel, C-terminal (IPR017933)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

P67805

UniProtKB/TrEMBL

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

modENCODE Anatomy RNA-Seq

modENCODE Development RNA-Seq

modENCODE Cell Lines RNA-Seq

modENCODE Treatments RNA-Seq

Expression Clusters

External Data & Images

Linkouts

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Dsim\GstD1	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Dsim\GstD1	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 1 unique term )

Terms Based on Experimental Evidence ( 1 term )

Molecular Function

CV term

Evidence

References

DDT-dehydrochlorinase activity

inferred from direct assay

(Low et al., 2010)

Biological Process ( 0 terms)

Cellular Component ( 0 terms)

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

gene

nuclear_gene

(Drosophila 12 Genomes Consortium, 2008)

protein_coding_gene

(Drosophila 12 Genomes Consortium, 2008)

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Dsim\GstD1 allele

Gene

References

External Data

Linkouts

Orthologs

OrthoDB Orthologs (1) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6BP1Z4

Dipteran inclusive ortholog search

EOG6SBF6X

Insect inclusive ortholog search

EOG6X96DJ

Arthropod inclusive ortholog search

EOG6QFTWF

Metazoa inclusive ortholog search

EOG6KHFPN

Ortholog(s) in Drosophila melanogaster (EOG6BP1Z4)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\GstD1

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (1) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila melanogaster

Dmel\GstD1

Stocks & Reagents

Stocks Listed in FlyBase ( 0 )

Genomic Clones ( 0 )

cDNA Clones ( 0 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

The frequency distribution of "silent" DNA polymorphisms has been studied in a number of D.simulans and D.pseudoobscura.pseudoobscura genes.

(Akashi and Schaeffer, 1997)

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

XM_002103697

RefSeq (Proteins)

•

XP_002103733

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

6728385

UniProtKB/Swiss-Prot

•

P67805

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Glutathione S-transferase, N-terminal (IPR004045)

Glutathione S-transferase, C-terminal (IPR004046)

Glutathione S-transferase, C-terminal-like (IPR010987)

Thioredoxin-like fold (IPR012336)

Glutathione S-transferase/chloride channel, C-terminal (IPR017933)

Linkouts

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0012838

Synonyms & Secondary IDs ( 11 )

Reported As

Symbol Synonym

DsGSTD1

(Low et al., 2010)

dsGSTD1

(Low et al., 2010)

dsim_GLEANR_4354

(Drosophila 12 Genomes Consortium, 2008)

Dsim\GstD1

(Drosophila 12 Genomes Consortium, 2008, )

gst

(Eickbush et al., 1995)

GST1

(Le Goff et al., 2001)

GstD1

(Drosophila 12 Genomes Consortium, 2008)

GSTD1

(Low et al., 2008, Low et al., 2007)

(Fuchs et al., 1992)

Name Synonym

glutathione S-transferase

(Hargis, 1992)

Glutathione S transferase D1

Secondary FlyBase IDs

References ( 19 )

Research paper

Low et al., 2010, J. Mol. Biol. 399(3): 358--366: Recognition and Detoxification of the Insecticide DDT by Drosophila melanogaster Glutathione S-Transferase D1. [FBrf0211172]
Drosophila 12 Genomes Consortium et al., 2007, Nature 450(7167): 203--218: Evolution of genes and genomes on the Drosophila phylogeny. [FBrf0200326]
Low et al., 2007, Genetics 177(3): 1363--1375: Molecular evolution of glutathione S-transferases in the genus drosophila. [FBrf0202224]
Bauer-DuMont et al., 2004, Genetics 167(1): 171--185: DNA variability and divergence at the Notch locus in Drosophila melanogaster and D. simulans: a case of accelerated synonymous site divergence. [FBrf0179198]
Dunn et al., 2001, Genetics 157(1): 295--305: Substitution rates in Drosophila nuclear genes. Implications for translational selection. [FBrf0132336]
Le Goff et al., 2001, Comp. Biochem. Physiol. B, Biochem. Mol. Biol. 129(4): 837--841: The sibling species Drosophila melanogaster and Drosophila simulans differ in the expression profile of glutathione S-transferases. [FBrf0136830]
Smilda et al., 1998, Biochem. Genet. 36(1-2): 15--36: Isolation of protease-free alcohol dehydrogenase (ADH) from Drosophila simulans and several homozygous and heterozygous Drosophila melanogaster variants. [FBrf0102400]
Akashi and Schaeffer, 1997, Genetics 146(1): 295--307: Natural selection and the frequency distributions of 'silent' DNA polymorphism in Drosophila. [FBrf0093333]
Moriyama and Powell, 1997, J. Mol. Evol. 45(4): 378--391: Synonymous substitution rates in Drosophila: mitochondrial versus nuclear genes. [FBrf0098855]
Moriyama and Powell, 1997, J. Mol. Evol. 45(5): 514--523: Codon usage bias and tRNA abundance in Drosophila. [FBrf0098854]
Akashi, 1996, Genetics 144(3): 1297--1307: Molecular evolution between Drosophila melanogaster and D. simulans: Reduced codon bias, faster rates of amino acid substitution, and larger proteins in D. melanogaster. [FBrf0090429]
Caccone et al., 1996, Mol. Biol. Evol. 13(9): 1224--1232: A molecular phylogeny for the Drosophila melanogaster subgroup and the problem of polymorphism data. [FBrf0090479]
Akashi, 1995, Genetics 139(2): 1067--1076: Inferring weak selection from patterns of polymorphism and divergence at 'silent' sites in Drosophila DNA. [FBrf0079841]
Eickbush et al., 1995, Genetics 139(2): 685--695: R1 and R2 retrotransposable elements of Drosophila evolve at rates similar to those of nuclear genes. [FBrf0080007]
Fuchs et al., 1992, Mutat. Res. 269: 185--191: Xenobiotic-metabolizing enzymes and benzo[a]pyrene metabolism in the benzo[a]pyrene-sensitive mutant strain of Drosophila simulans. [FBrf0057292]

Personal communication to FlyBase

Drosophila 12 Genomes Consortium, 2008, personal communication to FlyBase: Symbols and class of gene information for the GLEANR consensus sequences of the 11 sequenced non-melanogaster Drosophila species (Drosophila ananassae, erecta, grimshawi, mojavensis, persimilis, pseudoobscura, sechellia, simulans, willistoni, virilis and yakuba). [FBrf0202436]

Abstract

Low et al., 2008, A. Dros. Res. Conf. 49: 669C: Molecular Evolution of Glutathione S-Transferases in the Genus, Drosophila. [FBrf0203935]

FlyBase analysis

FlyBase, 2008, Newly sequenced Drosophila genomes: associations of GLEANR gene predictions (Releases 1.0) with previously known genes in FlyBase.: Newly sequenced Drosophila genomes: associations of GLEANR gene predictions (Releases 1.0) with previously known genes in FlyBase. [FBrf0202439]

DNA/RNA sequence record

Hargis, 1992, GenBank/EMBL/DDBJ: M84577: D.simulans glutathione S-transferase gene sequence. [FBrf0115780]