Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
4.5 (northern blot)
1051 (aa); 150 (kD observed); 115 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gp150 using the Feature Mapper tool.
Gp150 transcripts are most abundant between 3 and 12 hours of embryogenesis. Gp150 transcripts are expressed in most or all cells of the embryo. Elevated levels are observed along the ventral midline and in segmentally repeated lateral patches in the epithelium. At stage 12, expression is observed in stripes located just posterior to the segmental grooves.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Gp150 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Ptp10D and Gp150 form stable complexes in culture cells and in wild type larval tissue. Ptp10D cytoplasmic domain is sufficient to confer binding to Gp150. Results support the hypothesis that Ptp10D regulates Gp150 signaling in vivo.
Transmembrane Gp150 glycoprotein selectively interacts with the active site of the catalytic domain of Ptp10D (interaction is blocked by mutation of the active site or by the inhibitor vanadate). Ptp10D may function in vivo to regulate phosphorylation of Gp150 thereby controlling interactions with downstream effectors.