Gene Dmel\Gp150

General Information
Symbol	Dmel\Gp150	Species	D. melanogaster
Name	Gp150	Annotation symbol	CG5820
Feature type	protein_coding_gene	FlyBase ID	FBgn0013272
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	58D3-58D3	Sequence location	2R:18,205,167..18,216,933 [+]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Gp150 (CG5820, FBgn0013272). It has the cytological map location 58D3. Its sequence location is 2R:18205167..18216933. Its molecular function is described as: ATP binding; catalytic activity; protein binding. It is involved in the biological processes: transmembrane receptor protein tyrosine phosphatase signaling pathway; compound eye development; metabolic process. 25 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: peripheral nervous system; nervous system; organ system; adult; adult segment; adult mesothoracic segment; thoracic segment; sense organ; eye; anterior scutellar bristle. It has 4 annotated transcripts and 4 annotated polypeptides.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 58D3-58D3 Limits computationally determined from genome sequence between P{PZ}ari-2⁰⁷⁷⁶⁸ and P{lacW}l(2)k09801^k09801
Experimentally Determined Cytological Location
Cytogenetic map Notes References 58D1-58D3 (Zinn, 1994.9.28) 58D1-58D8 (Nakamura, 1996.8.8)
Experimentally Determined Recombination Data
Location	2- (Zhou et al., 1997, Nakamura, 1996.8.8, Zinn, 1994.9.28)
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References Overall orientation not stated: Gp150+ pgc+ T3dh- pgc+ (Nakamura et al., 1996) Overall orientation not stated: Gp150+ T3dh- (Nakamura, 1996.8.8)
Gene Model & Products
Please see the GBrowse view of Dmel\Gp150 for information on other features
Comments on Gene Model

Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gp150-RA FBtr0071813 NM_166527 4228 1051 Gp150-RB FBtr0071814 NM_166528 4256 1051 Gp150-RC FBtr0071815 NM_166529 4355 1051 Gp150-RD FBtr0071816 NM_057701 4202 1076
Additional Transcript Data & Comments
Reported size (kB)	4.5 (northern blot) (Tian and Zinn, 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein Gp150-PA FBpp0071726 118.2 1051 4.56 NP_726190 AAF46831 Gp150-PB FBpp0071727 118.2 1051 4.56 NP_726191 AAM68222 Gp150-PC FBpp0071728 118.2 1051 4.56 NP_726192 AAG22195 Gp150-PD FBpp0071729 121.0 1076 4.62 NP_477049 AAM68221
Additional Polypeptide Data & Comments
Reported size (kD)	1051 (aa); 150 (kD observed); 115 (kD predicted) (Tian and Zinn, 1994)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0013272
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Leucine-rich repeat (IPR001611) Leucine-rich repeat, typical subtype (IPR003591) Carbamoyl phosphate synthetase, large subunit, ATP-binding (IPR005479)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141523 AA141524 AA433234 AA694992 AA695579 AA802858 AA803395 AC005714 AE003457 AAF46831 AE003457 AAG22195 AE003457 AAM68221 AE003457 AAM68222 AI063579 AI108778 AI114003 AI257665 AI258365 AI296024 AI296937 AI387658 AI403748 AI405711 AI514660 AI531690 AI533819 AI534088 AI535027 AY029705 AAK39644 BG637198 BG641303 BI142246 BI167440 BI169877 BI172673 BI173263 BI212454 BI212602 BI215505 BI227740 BI227871 BI228686 BI229545 BI230390 BI231232 BI232051 BI233082 BI234109 BI235035 BI235427 BI235761 BI236207 BI236607 BI239185 BI239272 BI239345 BI240430 BI240488 BI241817 BI241962 BI352191 BI352530 BI356210 BI357302 BI357383 BI357408 BI357542 BI357587 BI358334 BI361681 BI361785 BI361930 BI363313 BI366491 BI367104 BI368637 BI369630 BI370038 BI370210 BI371064 BI371544 BI372533 BI374142 BI481797 BI482683 BI484215 BI484573 BI484711 BI486843 BI487042 BI578379 BI579837 BI580505 BP540657 BP540658 BP541351 BP548998 BP548999 BP549913 BP549914 BP556492 BP556493 BP557613 BP557614 BP559554 BP559555 BP560123 BP560124 BT011025 BT015195 AAT94424 CK01900 CK657050 CK657070 CK657243 CK659935 CK660564 CO176766 CO181408 CO195769 CO263227 CO263790 CO269755 CO269877 CO270290 CO277163 CO277244 CO290309 CO298953 CO305891 CO308201 CO309498 CO311072 CO313315 CO314016 CO320671 CO323871 CO332665 CO338455 CO342448 DN154227 EC060783 EC070396 EC072411 EC073394 EC075026 EC075165 EC079610 EC082135 EC083184 EC086281 EC088072 EC090649 EC194656 EC195250 EC197319 EC199229 EC200159 EC202783 EC203335 EC204758 EC209116 EC213518 EC214045 EC214796 EC221867 EC221908 EC223317 EC223708 EC224066 EC228273 EC230795 EC231834 EC232247 EC234358 EC238621 EC238747 EC243214 EC244946 EC247864 EC249416 EC250519 EC254848 EC266228 U15220 AAA61796 U66411 AAB71081 Z50242

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24007 Q6AWQ3 Q7JNM8 Q8MLT4 Q95PA9

Maps to	FBcl0297761 (FlyBase, 1992-)
Does NOT map to
Identified with	RE72245 RE46351 (BDGP Project Members, 2000-)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References deletion Gp150[k11107b] 2R:18,214,669..18,215,973 comment=A 1305bp deletion from exon 5 into exon 6. The deletion extends from amino acid 620 to 1040 and is followed by a frameshift and translation termination a few residues later. evidence=experimental (Li et al., 2003) point mutation Gp150[4] 2R:18,212,979..18,212,980 comment=G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). evidence=experimental pr_change=W119\|Gp150-PD,W94\|Gp150-PB,W94\|Gp150-PC, W94 \|Gp150-PA reported_na_change=G?A reported_pr_change=W94@ (Fetchko et al., 2002, Li et al., 2003) transposable element target site duplication P{lacW}Gp150[P8] 2R:18,205,512..18,205,519 comment=Position of 8bp P element repeat based on author statement that insertion maps 53bp into the 2nd intron of Gp150. evidence=experimental (Melnattur et al., 2002) transposable element target site duplication P{GawB}Gp150[52A] 2R:18,205,629..18,205,636 comment=Location of 8bp P element repeat based on author statement that insertion maps 170bp into the 2nd intron of Gp150. evidence=experimental (Melnattur et al., 2002)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 1336
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference embryonic stage (Tian and Zinn, 1994) embryonic stage (Tian and Zinn, 1994) embryonic stage \| stage 3-12 (Tian and Zinn, 1994) embryonic stage \| stage 10-12 ventral midline (Tian and Zinn, 1994)
Marker for

Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference larval stage eye disc (Li et al., 2003)
Marker for

Subcellular Localization
CV Term	plasma membrane (Tian and Zinn, 1994)
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013272 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0013272</