n-syb, n-synaptobrevin, syb, synaptobrevin
a v-SNARE - a vesicular protein that plays a key role during synaptic vesicle exocytosis - involved in a neuron-specific sort-and-degrade mechanism that protects neurons from degeneration
Please see the GBrowse view of Dmel\nSyb or the JBrowse view of Dmel\nSyb for information on other features
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Gene model reviewed during 5.44
Gene model reviewed during 5.55
3.2, 3.0 (northern blot)
22 (kD observed)
181 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\nSyb using the Feature Mapper tool.
n-syb transcripts are first detected in 9-12hr embryos on northern blots and are detected at all subsequent stages tested. The two transcripts are present in roughly equal amounts until adulthood at which point the 3.0kb transcript predominates. n-syb transcripts are more abundant in adult head than body.
n-syb transcripts are first detected in embryos at stage 13 and are restricted to the nervous system. They become quite abundant in both the central and peripheral nervous sytems. In adults, transcripts are detected in the cell bodies of the visual system, in the central brain and in the thoracic ganglia.
n-syb protein staining is strong in the ventral nerve cord in embryos and is faint in axon commissures and segmental and intersegmental nerves. Staining is also apparent at the neuromuscular junction (NMJ). It is concentrated in the synaptic zones at the NMJ.
n-syb protein is largely restricted to the presynaptic boutons in larval neuromuscular junctions. Low levels of expression are seen in the motor axons.
GBrowse - Visual display of RNA-Seq signals
View Dmel\nSyb in GBrowse 23-0.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Source for identity of: n-Syb n-syb
Source for identity of: nSyb n-syb
Ctet\TeTxLC expressed in transgenic flies cleaves n-syb and abolishes synaptic transmission at a defined neuromuscular junction.
