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Gene Dmel\Syx1A

General Information
Symbol	Dmel\Syx1A	Species	D. melanogaster
Name	Syntaxin 1A	Annotation symbol	CG31136
Feature type	protein_coding_gene	FlyBase ID	FBgn0013343
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	syx, syx-1A, syx1, CG5448
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	95E1-95E1	Sequence location	3R:19,927,322..19,931,465 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Syntaxin 1A is referred to in FlyBase by the symbol Dmel\Syx1A (CG31136, FBgn0013343). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: SNAP receptor activity. There is experimental evidence that it is involved in the biological process: haltere development; synaptic vesicle fusion to presynaptic membrane; cytokinesis; regulation of pole plasm oskar mRNA localization. 45 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; external compound sense organ; cuticle; non-connected developing system; synapse; nervous system; cuticular specialization; cellular component organization or biogenesis; actomyosin contractile ring; embryonic hindgut; female germline cyst; primordium; cephalopharyngeal skeleton; embryonic foregut; adult segment. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Syntaxin, N-terminal; Syntaxin/epimorphin, conserved site; Target SNARE coiled-coil domain; t-SNARE. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1624043_at aligns to a genomic region shared by exons of 2 FlyBase-annotated genes; hence it is impossible to interpret the expression pattern and levels of Syx1A expression signal. See the GBrowse view of Syx1A to determine the overlapping gene(s). Gene sequence location is 3R:19927322..19931465.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Williamson et al., 2010, J. Cell Biol. 189(5): 885--899 Sequence features HFA15359 BKN40892
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95E1-95E1   Limits computationally determined from genome sequence between P{PZ}Atg600096 and P{PZ}Syx1A06737&P{PZ}Syx1A10660
Experimentally Determined Cytological Location
Cytogenetic map Notes References 95E1-95E2     (Schulze, 1994.11.18) 95E1-95E2   (determined by in situ hybridisation)   (Spradling et al., 1999) 95E1-95E2   (determined by in situ hybridisation)   (Perrimon et al., 1996) 95E1-95E2     (BDGP Project Members, 1994-1999) 95E-95E   Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.   (Lloyd et al., 2000)
Experimentally Determined Recombination Data
Location	3-81 (Littleton et al., 1998) 3- (Schulze, 1994.11.18)
Left of (cM)	Dr Pr (Littleton et al., 1998)
Right of (cM)	Gl Sb H (Littleton et al., 1998)
Notes	Syx1A3-69 used in recombination mapping. (Littleton et al., 1998)
Gene Model & Products
Please see the GBrowse view of Dmel\Syx1A for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Shares 3' UTR sequences with upstream gene.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Syx1A-RA FBtr0084588  NM_079751   2365   291 Syx1A-RB FBtr0303161  NM_001202347   2619   296
Additional Transcript Data & Comments
Reported size (kB)	12, 9, 8, 7, 4.4, 3.5 (northern blot) (Schulze and Bellen, 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Syx1A-PA   FBpp0083973   33.6   291   5.09     NP_524475   AAF56232 Syx1A-PB   FBpp0292260   34.2   296   5.20     NP_001189276   ADV37366
Additional Polypeptide Data & Comments
Reported size (kDa)	291 (aa); 35 (kD observed) (Schulze et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Target SNARE coiled-coil domain (IPR000727) Syntaxin, N-terminal (IPR006011) Syntaxin/epimorphin, conserved site (IPR006012) t-SNARE (IPR010989)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA697968   AE014297 AAF56232   AE014297 ADV37366   AF007164   AI388289   AI512186   AI515701   AQ073351   AQ073825   AW943688   AX664480   AY061472 AAL29020   BI354934   BI606618   BI632315   BP543306   BP543307   BP546299   BP548100   BP548158   BP549847   BP549848   BP553523   BP553524   BP555197   BP555198   BT124868   CO155384   CO155399   CO179084   CO179298   CO179400   CO179420   CO188077   CO194420   CO196555   CO262146   CO266021   CO277718   CO297151   CO302702   CO304511   CO307999   CO309902   CO319912   CO332995   CO332997   CO335919   CO344948   CZ470292   EC057730   EC059081   EC068315   EC068340   EC079318   EC087444   EC087546   EC088756   EC195883   EC199004   EC201871   EC205330   EC209175   EC215926   EC215943   EC218704   EC226539   EC230319   EC237319   EC238670   EC246365   EC262194   EC265672   EC266881   EC267485   FF579600   G01403   GH942030   GH942205   GH943322   GH947109   GH949840   GH954978   GH960027   GH962365   GH967264   GH978422   GH978510   GH982486   GH984203   L37732 AAA75649
UniProtKB/Swiss-Prot	Q24547
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval peripheral nervous system   (Schulze et al., 1995) posterior midgut primordium   (Schulze et al., 1995) anterior midgut primordium   (Schulze et al., 1995) embryonic/larval neuron   (Schulze et al., 1995) central nervous system   (Schulze et al., 1995) embryonic/larval garland cell   (Schulze et al., 1995) embryonic stage | early   organism | ubiquitous   (Schulze and Bellen, 1996) organism | 0% egg length   (Schulze and Bellen, 1996) Comment:0-1% egg length embryonic stage 9   anterior midgut primordium   (Schulze and Bellen, 1996) ectoderm   (Schulze and Bellen, 1996) neuroblast   (Schulze and Bellen, 1996) amnioproctodeal invagination   (Schulze and Bellen, 1996) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Schulze and Bellen, 1996)
Additional Descriptive Data
	Syx1A expression is widespread in the embryo prior to stage 12. After this, expression in ectodermal cells has faded and expression is observed mainly in the anterior and posterior midguts, the garland cells, and the CNS. By stage 14, the major sites of expression are the CNS and the garland cells. Weaker expression is observed in the PNS. (Schulze et al., 1995) In situ hybridization reveals that Syx1A transcripts are present throuhgout precellularized embryos though they are most prevalent at the posterior pole. After cellularization, Syx1A transcripts are present in all cells and appear to be concentrated near the cell membrane. In stage 9 embryos, transcripts are observed in the anterior and posterior midgut invaginations as well as in the ventral neuroblasts and the ectoderm. (Schulze and Bellen, 1996) Syx1A transcripts are expressed in a complex pattern throughout development. Up to six transcripts are observed at any given stage on northern blots. In early embryos, the 3.5, 4.2, and 8.0kb transcripts are abundant. In 3-9hr embryos, the 4.2, 8.0, and 9.0kb transcripts predominate. The 7.0 and 12.0kb transcripts appear after 9hr. In first instar larvae, 5 transcripts are prominent. In second and third instar larvae, the number of abundant transcripts is reduced to three and two, respectively. During pupation, 5 transcripts reappear and are also seen in adults. (Schulze and Bellen, 1996)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference larval stage   neuron   • axon (Broadie et al., 1995) bouton   (Broadie et al., 1995) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval garland cell   (Schulze et al., 1995) presumptive embryonic/larval peripheral nervous system   (Schulze et al., 1995) central nervous system   (Schulze et al., 1995) commissure   (Schulze et al., 1995) neuromuscular junction   (Schulze et al., 1995) neuron   • synaptic vesicle (Schulze et al., 1995) longitudinal connective   (Schulze et al., 1995) neuron   • axon (Schulze et al., 1995) cell body   (Schulze et al., 1995) embryonic stage | early   organism | ubiquitous   (Schulze and Bellen, 1996) pole bud   (Schulze and Bellen, 1996) embryonic stage 9   ectoderm   (Schulze and Bellen, 1996) mesoderm   (Schulze and Bellen, 1996) ventral neurogenic region   (Schulze and Bellen, 1996) embryonic stage 15 -- 17   anterior embryonic/larval midgut   (Schulze et al., 1995) posterior embryonic/larval midgut   (Schulze et al., 1995) ectoderm   (Schulze et al., 1995) larval stage   neuromuscular junction   (Broadie et al., 1995) synapse   (Broadie et al., 1995) third instar larval stage   embryonic/larval neuromuscular junction   • terminal button (Bronk et al., 2001) adult stage   lamina   (Schulze and Bellen, 1996, Hiesinger et al., 2001) medulla   (Schulze and Bellen, 1996) adult brain   (Schulze and Bellen, 1996) photoreceptor cell   • plasma membrane of terminal button (Hiesinger et al., 2001) adult stage & oogenesis   germarium region 2b   (Schulze and Bellen, 1996) germline cyst   (Schulze and Bellen, 1996) germarium region 3   (Schulze and Bellen, 1996) germarium region 2a   (Schulze and Bellen, 1996) adult stageoogenesis stage S1 -- S8   nurse cell   (Schulze and Bellen, 1996)
Additional Descriptive Data
	Syx1A protein is enriched in membrane fractions and is associated with synaptic vesicles and possibly other small vesicles such as endosomes. (Broadie et al., 1995, Schulze et al., 1995) Syx1A protein is detected in germarium regions 2 and 3 outlining the membranes of the cyst cells. It continues to be abundantly expressed in the nurse cells during oogenesis stages S1-S8. Levels fade during stages S8 and S9. In early embryos, Syx1A protein is present ubiquitously but is concentrated at the posterior tip where it accumulates under the pole buds. At mitotic cycle 13, the protein is concentrated in hexagonal-shaped outlines that correspond to the cleavage furrows of the cytoplasmic buds. After cellularization it is present in all of the membranes of all cells. During germband extension, it is present in the mesoderm, ectoderm, and invaginating neurectoderm but is excluded from the amnioserosa. Syx1A protein is also present in the adult brain and the synaptic substations of the visual system. In the brain it is concentrated in neuropil regions and is somewhat enriched at synaptic regions such as the lamina and the medulla. (Schulze and Bellen, 1996) syx1a protein is present primarily in the CNS and garland cells though some staining is seen in the ectoderm and the midgut in stages 15-17. In the CNS, staining is most prominent along the longitudinal tracts of the ventral nerve cord and brain but is also found in the commissures of the CNS and the axons of the peripheral nerves. In the periphery of the embryo, staining is seen in neuromuscular junctions and at low levels in some cell bodies. (Schulze et al., 1995)
Marker for
Subcellular Localization
CV Term	synaptic vesicle (Schulze et al., 1995)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0013343    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0013343 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0013343 expression level Developmental Stage   Expression Level embryo 00-02hr    1152 embryo 02-04hr    2176 embryo 04-06hr    2579 embryo 06-08hr    1371 embryo 08-10hr    1412 embryo 10-12hr    1016 embryo 12-14hr    1282 embryo 14-16hr    1598 embryo 16-18hr    2296 embryo 18-20hr    2376 embryo 20-22hr    3246 embryo 22-24hr    3310 larva L1    2205 larva L2    1533 larva L3 12hr old    1053 larva L3 puffstage 1-2    487 larva L3 puffstage 3-6    1055 larva L3 puffstage 7-9    1007 white prepupae new    974 white prepupae 12hr    939 white prepupae 24hr    1167 pupae 2d postWPP    1562 pupae 3d postWPP    1770 pupae 4d postWPP    1336 adult male 01day    1364 adult male 05day    1211 adult male 30day    1026 adult female 01day    1046 adult female 05day    977 adult female 30day    1005 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1152) embryo 02-04hr  (2176) embryo 04-06hr  (2579) embryo 06-08hr  (1371) embryo 08-10hr  (1412) embryo 10-12hr  (1016) embryo 12-14hr  (1282) embryo 14-16hr  (1598) embryo 16-18hr  (2296) embryo 18-20hr  (2376) embryo 20-22hr  (3246) embryo 22-24hr  (3310) larva L1  (2205) larva L2  (1533) larva L3 12hr old  (1053) larva L3 puffstage 1-2  (487) larva L3 puffstage 3-6  (1055) larva L3 puffstage 7-9  (1007) white prepupae new  (974) white prepupae 12hr  (939) white prepupae 24hr  (1167) pupae 2d postWPP  (1562) pupae 3d postWPP  (1770) pupae 4d postWPP  (1336) adult male 01day  (1364) adult male 05day  (1211) adult male 30day  (1026) adult female 01day  (1046) adult female 05day  (977) adult female 30day  (1005) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1152 embryo 02-04hr  (2176) embryo 04-06hr  (2579) embryo 06-08hr    1371 embryo 08-10hr  1412 embryo 10-12hr    1016 embryo 12-14hr    1282 embryo 14-16hr  (1598) embryo 16-18hr  (2296) embryo 18-20hr  (2376) embryo 20-22hr  (3246) embryo 22-24hr  (3310) larva L1  (2205) larva L2  (1533) larva L3 12hr old    1053 larva L3 puffstage 1-2    487 larva L3 puffstage 3-6    1055 larva L3 puffstage 7-9    1007 white prepupae new    974 white prepupae 12hr    939 white prepupae 24hr    1167 pupae 2d postWPP  (1562) pupae 3d postWPP  (1770) pupae 4d postWPP    1336 adult male 01day    1364 adult male 05day    1211 adult male 30day    1026 adult female 01day    1046 adult female 05day    977 adult female 30day    1005 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1152 embryo 02-04hr    2176 embryo 04-06hr    2579 embryo 06-08hr    1371 embryo 08-10hr    1412 embryo 10-12hr    1016 embryo 12-14hr    1282 embryo 14-16hr    1598 embryo 16-18hr    2296 embryo 18-20hr    2376 embryo 20-22hr    3246 embryo 22-24hr    3310 larva L1    2205 larva L2    1533 larva L3 12hr old    1053 larva L3 puffstage 1-2    487 larva L3 puffstage 3-6    1055 larva L3 puffstage 7-9    1007 white prepupae new    974 white prepupae 12hr    939 white prepupae 24hr    1167 pupae 2d postWPP    1562 pupae 3d postWPP    1770 pupae 4d postWPP    1336 adult male 01day    1364 adult male 05day    1211 adult male 30day    1026 adult female 01day    1046 adult female 05day    977 adult female 30day    1005 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1152 embryo 02-04hr    2176 embryo 04-06hr    2579 embryo 06-08hr    1371 embryo 08-10hr    1412 embryo 10-12hr    1016 embryo 12-14hr    1282 embryo 14-16hr    1598 embryo 16-18hr    2296 embryo 18-20hr    2376 embryo 20-22hr    3246 embryo 22-24hr    3310 larva L1    2205 larva L2    1533 larva L3 12hr old    1053 larva L3 puffstage 1-2    487 larva L3 puffstage 3-6    1055 larva L3 puffstage 7-9    1007 white prepupae new    974 white prepupae 12hr    939 white prepupae 24hr    1167 pupae 2d postWPP    1562 pupae 3d postWPP    1770 pupae 4d postWPP    1336 adult male 01day    1364 adult male 05day    1211 adult male 30day    1026 adult female 01day    1046 adult female 05day    977 adult female 30day    1005 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0013343 expression level Developmental Stage   Expression Level embryo 00-02hr    1152 embryo 02-04hr    2176 embryo 04-06hr    2579 embryo 06-08hr    1371 embryo 08-10hr    1412 embryo 10-12hr    1016 embryo 12-14hr    1282 embryo 14-16hr    1598 embryo 16-18hr    2296 embryo 18-20hr    2376 embryo 20-22hr    3246 embryo 22-24hr    3310 larva L1    2205 larva L2    1533 larva L3 12hr old    1053 larva L3 puffstage 1-2    487 larva L3 puffstage 3-6    1055 larva L3 puffstage 7-9    1007 white prepupae new    974 white prepupae 12hr    939 white prepupae 24hr    1167 pupae 2d postWPP    1562 pupae 3d postWPP    1770 pupae 4d postWPP    1336 adult male 01day    1364 adult male 05day    1211 adult male 30day    1026 adult female 01day    1046 adult female 05day    977 adult female 30day    1005 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1152) embryo 02-04hr  (2176) embryo 04-06hr  (2579) embryo 06-08hr  (1371) embryo 08-10hr  (1412) embryo 10-12hr  (1016) embryo 12-14hr  (1282) embryo 14-16hr  (1598) embryo 16-18hr  (2296) embryo 18-20hr  (2376) embryo 20-22hr  (3246) embryo 22-24hr  (3310) larva L1  (2205) larva L2  (1533) larva L3 12hr old  (1053) larva L3 puffstage 1-2  (487) larva L3 puffstage 3-6  (1055) larva L3 puffstage 7-9  (1007) white prepupae new  (974) white prepupae 12hr  (939) white prepupae 24hr  (1167) pupae 2d postWPP  (1562) pupae 3d postWPP  (1770) pupae 4d postWPP  (1336) adult male 01day  (1364) adult male 05day  (1211) adult male 30day  (1026) adult female 01day  (1046) adult female 05day  (977) adult female 30day  (1005) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1152 embryo 02-04hr  2176 embryo 04-06hr  (2579) embryo 06-08hr    1371 embryo 08-10hr  1412 embryo 10-12hr    1016 embryo 12-14hr    1282 embryo 14-16hr  1598 embryo 16-18hr  2296 embryo 18-20hr  2376 embryo 20-22hr  (3246) embryo 22-24hr  (3310) larva L1  2205 larva L2  1533 larva L3 12hr old    1053 larva L3 puffstage 1-2    487 larva L3 puffstage 3-6    1055 larva L3 puffstage 7-9    1007 white prepupae new    974 white prepupae 12hr    939 white prepupae 24hr    1167 pupae 2d postWPP  1562 pupae 3d postWPP  1770 pupae 4d postWPP    1336 adult male 01day    1364 adult male 05day    1211 adult male 30day    1026 adult female 01day    1046 adult female 05day    977 adult female 30day    1005 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1152 embryo 02-04hr    2176 embryo 04-06hr    2579 embryo 06-08hr    1371 embryo 08-10hr    1412 embryo 10-12hr    1016 embryo 12-14hr    1282 embryo 14-16hr    1598 embryo 16-18hr    2296 embryo 18-20hr    2376 embryo 20-22hr    3246 embryo 22-24hr    3310 larva L1    2205 larva L2    1533 larva L3 12hr old    1053 larva L3 puffstage 1-2    487 larva L3 puffstage 3-6    1055 larva L3 puffstage 7-9    1007 white prepupae new    974 white prepupae 12hr    939 white prepupae 24hr    1167 pupae 2d postWPP    1562 pupae 3d postWPP    1770 pupae 4d postWPP    1336 adult male 01day    1364 adult male 05day    1211 adult male 30day    1026 adult female 01day    1046 adult female 05day    977 adult female 30day    1005 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1152 embryo 02-04hr    2176 embryo 04-06hr    2579 embryo 06-08hr    1371 embryo 08-10hr    1412 embryo 10-12hr    1016 embryo 12-14hr    1282 embryo 14-16hr    1598 embryo 16-18hr    2296 embryo 18-20hr    2376 embryo 20-22hr    3246 embryo 22-24hr    3310 larva L1    2205 larva L2    1533 larva L3 12hr old    1053 larva L3 puffstage 1-2    487 larva L3 puffstage 3-6    1055 larva L3 puffstage 7-9    1007 white prepupae new    974 white prepupae 12hr    939 white prepupae 24hr    1167 pupae 2d postWPP    1562 pupae 3d postWPP    1770 pupae 4d postWPP    1336 adult male 01day    1364 adult male 05day    1211 adult male 30day    1026 adult female 01day    1046 adult female 05day    977 adult female 30day    1005 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0013343    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0013343 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0013343 expression level Tissue   Expression Level Larval Central Nervous System    38 Larval Midgut no informative data Larval Hindgut    32.3 Larval Malpighian Tubules no informative data Larval Fat Body    9.7 Larval Salivary Gland    26.6 Larval Trachea    53.225 Larval Carcass    21.975 Adult Head no informative data Adult Eye    36.325 Adult Brain    91.3 Adult Thoracic-Abdominal Ganglion    92.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.4 Adult Malpighian Tubules    7.6 Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    43.025 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis    20.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    38 Larval Midgut no informative data Larval Hindgut    32.3 Larval Malpighian Tubules no informative data Larval Fat Body    9.7 Larval Salivary Gland    26.6 Larval Trachea    53.225 Larval Carcass    21.975 Adult Head no informative data Adult Eye    36.325 Adult Brain    91.3 Adult Thoracic-Abdominal Ganglion    92.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.4 Adult Malpighian Tubules    7.6 Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    43.025 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis    20.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    38 Larval Midgut no informative data Larval Hindgut    32.3 Larval Malpighian Tubules no informative data Larval Fat Body    9.7 Larval Salivary Gland    26.6 Larval Trachea    53.225 Larval Carcass    21.975 Adult Head no informative data Adult Eye    36.325 Adult Brain    91.3 Adult Thoracic-Abdominal Ganglion    92.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.4 Adult Malpighian Tubules    7.6 Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    43.025 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis    20.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    38 Larval Midgut no informative data Larval Hindgut    32.3 Larval Malpighian Tubules no informative data Larval Fat Body    9.7 Larval Salivary Gland    26.6 Larval Trachea    53.225 Larval Carcass    21.975 Adult Head no informative data Adult Eye    36.325 Adult Brain    91.3 Adult Thoracic-Abdominal Ganglion    92.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.4 Adult Malpighian Tubules    7.6 Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    43.025 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis    20.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0013343 expression level Tissue   Expression Level Larval Central Nervous System    38 Larval Midgut no informative data Larval Hindgut    32.3 Larval Malpighian Tubules no informative data Larval Fat Body    9.7 Larval Salivary Gland    26.6 Larval Trachea    53.225 Larval Carcass    21.975 Adult Head no informative data Adult Eye    36.325 Adult Brain    91.3 Adult Thoracic-Abdominal Ganglion    92.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.4 Adult Malpighian Tubules    7.6 Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    43.025 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis    20.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    38 Larval Midgut no informative data Larval Hindgut    32.3 Larval Malpighian Tubules no informative data Larval Fat Body    9.7 Larval Salivary Gland    26.6 Larval Trachea    53.225 Larval Carcass    21.975 Adult Head no informative data Adult Eye    36.325 Adult Brain    91.3 Adult Thoracic-Abdominal Ganglion    92.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.4 Adult Malpighian Tubules    7.6 Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    43.025 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis    20.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    38 Larval Midgut no informative data Larval Hindgut    32.3 Larval Malpighian Tubules no informative data Larval Fat Body    9.7 Larval Salivary Gland    26.6 Larval Trachea    53.225 Larval Carcass    21.975 Adult Head no informative data Adult Eye    36.325 Adult Brain    91.3 Adult Thoracic-Abdominal Ganglion    92.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.4 Adult Malpighian Tubules    7.6 Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    43.025 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis    20.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    38 Larval Midgut no informative data Larval Hindgut    32.3 Larval Malpighian Tubules no informative data Larval Fat Body    9.7 Larval Salivary Gland    26.6 Larval Trachea    53.225 Larval Carcass    21.975 Adult Head no informative data Adult Eye    36.325 Adult Brain    91.3 Adult Thoracic-Abdominal Ganglion    92.7 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    29.4 Adult Malpighian Tubules    7.6 Adult Fat Body    8.2 Adult Salivary Gland no informative data Adult Heart    43.025 Adult VirginFemale Spermatheca    4 Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis    20.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    36.325   NA  Brain    91.3   38  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    92.7   NA  Crop    no informative data   no informative data  Midgut    no informative data   32.3  Hindgut    29.4   no informative data  Malpighian Tubules    7.6   9.7  Fat Body    8.2   26.6  Salivary Gland    no informative data   NA  Heart    43.025   53.225  Trachea    NA   NA  VirginFemale Spermatheca    4   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    no informative data   NA  Testis    20.4   NA  Male Accessory Gland    no informative data   21.975  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013343 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33100-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Syx1AGD564 lethal | embryonic stage Syx1AΔ229 lethal | embryonic stage, with Syx1AA243V.V247A Syx1AΔ229 lethal | embryonic stage, with Syx1AΔ229 Syx1AA243V.V247A lethal | embryonic stage | maternal effect Syx1AΔ229 lethal | embryonic stage | recessive Syx1A2 Syx1A14 Syx1A17 Syx1A86 Syx1A118 Syx1A284 Syx1A294 Syx1A06737 Syx1AΔ229 lethal | embryonic stage | recessive | rescuable maternal effect Syx1AL266 lethal | embryonic stage | rescuable maternal effect Syx1A06737 lethal | partially Syx1A177 Syx1A204 Syx1A287 lethal | recessive Syx1A1 Syx1A15ts Syx1A05618 Syx1A06737 Syx1A10660 Syx1Aj4D9 Syx1AL371 Syx1AΔ6 Syx1AΔ229 viable Syx1A4 Syx1Ahs.PW viable, with Syx1A+t13.5 Syx1AΔ229 viable, with Syx1AΔ229 Syx1A+t13.5 Other Phenotypes Allele cytokinesis defective Syx1AdsRNA.358-1114 hypoactive, with Syx1AA243V.V247A Syx1AΔ229 hypoactive, with Syx1AΔ229 Syx1AA243V.V247A neuroanatomy defective Syx1A3-69 neuroanatomy defective | embryonic stage Syx1AΔ229 neuroanatomy defective | embryonic stage | recessive Syx1AΔ229 neurophysiology defective Syx1A06737 Syx1AH3-C Syx1AH3-N neurophysiology defective, with Syx1AA243V.V247A Syx1AΔ229 neurophysiology defective, with Syx1AΔ229 Syx1AA243V.V247A neurophysiology defective | embryonic stage | recessive Syx1AΔ229 neurophysiology defective | heat sensitive Syx1A3-69 neurophysiology defective | heat sensitive, with Scer\GAL4elav-C155, Syx1A3-69, Syx1AScer\UAS.cBa Syx1AΔ229 neurophysiology defective | heat sensitive, with Scer\GAL4elav-C155, Syx1AΔ229, Syx1A3-69 Syx1AScer\UAS.cBa neurophysiology defective | heat sensitive, with Scer\GAL4elav-C155, Syx1AΔ229, Syx1AScer\UAS.cBa Syx1A3-69 neurophysiology defective | heat sensitive, with Scer\GAL4elav-C155, Syx1AΔ229/Syx1A3-69 Syx1AScer\UAS.cBa neurophysiology defective | heat sensitive (with Syx1A3-69) Syx1AΔ229 neurophysiology defective | heat sensitive (with Syx1A3-69), with Scer\GAL4elav-C155, Syx1AScer\UAS.cBa Syx1AΔ229 neurophysiology defective | heat sensitive (with Syx1AΔ229) Syx1A3-69 neurophysiology defective | heat sensitive (with Syx1AΔ229), with Scer\GAL4elav-C155, Syx1AScer\UAS.cBa Syx1A3-69 neurophysiology defective | larval stage (with Syx1AL2) Syx1AL247 neurophysiology defective | larval stage (with Syx1AL247) Syx1AL2 neurophysiology defective | larval stage | heat sensitive Syx1Ahs.PW paralytic | heat sensitive Syx1A3-69 paralytic | semidominant | heat sensitive Syx1A3-69 uncoordinated | dominant | heat sensitive Syx1A3-69 visible | recessive | somatic clone Syx1AL371 visual behavior defective | recessive | heat sensitive Syx1A3-69 wild-type Syx1A+t6 Syx1A+t11 Syx1A+t13.5 Syx1A+t13 Syx1AI212A Syx1AI236A Phenotype manifest in Allele actomyosin contractile ring Syx1AdsRNA.358-1114 cytoskeleton | embryonic stage | germline clone Syx1AL266 denticle Syx1AΔ229 Syx1AH3-N denticle belt Syx1AΔ229 egg | germline clone Syx1AL266 embryo | germline clone Syx1AL266 embryonic/first instar larval cuticle Syx1AΔ229 Syx1A06737 Syx1A14 Syx1A284 Syx1A86 Syx1AH3-N embryonic/first instar larval cuticle | maternal effect Syx1AΔ229 embryonic/larval midgut | embryonic stage | maternal effect Syx1AΔ229 embryonic/larval midgut primordium Syx1AΔ229 embryonic/larval muscle system Syx1AΔ229 Syx1AH3-C Syx1AH3-N embryonic epidermis Syx1AΔ229 Syx1AH3-C Syx1AH3-N embryonic foregut Syx1AΔ229 embryonic hindgut Syx1AΔ229 eye, with Scer\GAL4GMR.PF Syx1AScer\UAS.cBa eye photoreceptor cell | somatic clone Syx1AL371 intersegmental nerve | embryonic stage Syx1AΔ6 intersegmental nerve | embryonic stage | maternal effect Syx1AΔ229 longitudinal connective Syx1AΔ6 longitudinal connective | maternal effect Syx1AΔ229 mitotic telophase Syx1AdsRNA.358-1114 mitotic telophase & spindle Syx1AdsRNA.358-1114 mouth hooks Syx1AΔ229 neuromuscular junction Syx1AΔ229 Syx1AH3-C Syx1AH3-N Syx1AI212A Syx1AI236A neuromuscular junction | embryonic stage Syx1A06737 Syx1A118 Syx1A17 Syx1A2 Syx1A294 neuromuscular junction | larval stage Syx1Ahs.PW nucleus | embryonic stage | germline clone Syx1AL266 ommatidium Syx1AΔ6 Syx1A06737 Syx1A118 Syx1A14 Syx1A15ts Syx1A17 Syx1A177 Syx1A2 Syx1A204 Syx1A284 Syx1A287 Syx1A294 Syx1A4 Syx1A86 ommatidium, with Scer\GAL4GMR.PF Syx1AScer\UAS.cBa ommatidium | maternal effect Syx1AΔ229 oocyte Syx1AΔ229 oocyte | germline clone Syx1AL371 optic cartridge & synaptic vesicle Syx1A3-69 retina Syx1A3-69 segmental nerve | embryonic stage Syx1AΔ6 segmental nerve | embryonic stage | maternal effect Syx1AΔ229 somatic muscle Syx1A06737 synapse (with Syx1AL2) Syx1AL247 synapse (with Syx1AL247) Syx1AL2 synapse | embryonic stage, with Syx1AA243V.V247A Syx1AΔ229 synapse | embryonic stage, with Syx1AΔ229 Syx1AA243V.V247A ventral nerve cord Syx1AΔ229 ventral nerve cord | maternal effect Syx1AΔ229 wing Syx1AΔ6 Syx1A06737 Syx1A118 Syx1A14 Syx1A15ts Syx1A17 Syx1A177 Syx1A2 Syx1A204 Syx1A284 Syx1A287 Syx1A294 Syx1A4 Syx1A86 wing | maternal effect Syx1AΔ229
Classical Alleles ( 29 )
For All Classical Alleles Show
Allele of Syx1A Class Mutagen Stocks Known lesion Syx1AΔ229 amorphic allele - genetic evidence, loss of function allele Delta2-3 2 Yes Syx1A06737 hypomorphic allele - genetic evidence P-element activity 1 Yes Syx1ADG10811 1 -- Syx1A05618 P-element activity 0 -- Syx1A10660 P-element activity 0 Yes Syx1A118 Delta2-3 0 Yes Syx1A14 hypomorphic allele - genetic evidence Delta2-3 0 Yes Syx1A15ts ethyl methanesulfonate 0 -- Syx1A177 hypomorphic allele - genetic evidence Delta2-3 0 Yes Syx1A17 Delta2-3 0 Yes Syx1A1 loss of function allele ethyl methanesulfonate 0 Yes Syx1A204 hypomorphic allele - genetic evidence Delta2-3 0 Yes Syx1A284 hypomorphic allele - genetic evidence Delta2-3 0 Yes Syx1A287 hypomorphic allele - genetic evidence Delta2-3 0 Yes Syx1A294 Delta2-3 0 Yes Syx1A2 Delta2-3 0 Yes Syx1A3-69 ethyl methanesulfonate 0 Yes Syx1A4 hypomorphic allele - genetic evidence Delta2-3 0 Yes Syx1A86 hypomorphic allele - genetic evidence Delta2-3 0 Yes Syx1Ac05841 piggyBac transposase 0 -- Syx1AEP28 P-element activity 0 Yes Syx1AEP3215 P-element activity 0 Yes Syx1Aj4D9 P-element activity 0 -- Syx1Aj5E6 0 -- Syx1AL247 P-element activity 0 -- Syx1AL266 hypomorphic allele - genetic evidence P-element activity 0 Yes Syx1AL2 P-element activity 0 -- Syx1AL371 loss of function allele P-element activity 0 Yes Syx1AΔ6 hypomorphic allele - genetic evidence Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Syx1A Class Mutagen Stocks Known lesion Syx1AGD564 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Syx1AJF01829 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Syx1A+t11 in vitro construct - genomic fragment 0 Yes Syx1A+t13.5 in vitro construct - genomic fragment 0 Yes Syx1A+t13 in vitro construct - genomic fragment 0 Yes Syx1A+t6 in vitro construct - genomic fragment 0 Yes Syx1AA243V.V247A loss of function allele in vitro construct - amino acid replacement 0 Yes Syx1ADN.Scer\UAS in vitro construct - regulatory fusion 0 Yes Syx1AdsRNA.358-1114 in vitro construct - RNAi 0 Yes Syx1AH3-C in vitro construct - deletion 0 Yes Syx1AH3-N in vitro construct - deletion 0 Yes Syx1Ahs.PW in vitro construct - regulatory fusion 0 Yes Syx1AI212A in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes Syx1AI236A in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 0 Yes Syx1AScer\UAS.cBa in vitro construct - regulatory fusion 0 Yes Syx1AtCH322-142K16 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)ri-XT1 (BDGP Project Members, 1994-1999) Df(3R)crb87-4 (Littleton et al., 1998, Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3R)crb-F89-4 (Schulze et al., 1995, Schulze and Bellen, 1996) Df(3R)Exel6197 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD564} NA P{TRiP.JF01829} NA P{UAS-syx1A.B} NA P{UAS-Syx1A.DN} NA P{UAS-Syx1A.S} NA heat-shock construct P{hs-syx1A.W} NA characterization construct P{Syx1A.A243V.V247A} NA P{syx1A+t13.5} NA P{syx1AH3-C} NA P{syx1AH3-N} NA P{syx1AI212A} NA P{syx1AI216A} NA P{syx+6} NA P{syx+11} NA P{syx+13} NA PBac{CH322-142K16} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Syx1AEP28 NA P{EP}Syx1AEP3215 NA P{GSV1}C790C790 NA insertion of enhancer trap P{lacW}Syx1Aj4D9 No P{lacZ}Syx1AL2 No P{lacZ}Syx1AL247 No P{PZ}Syx1A05618 No P{PZ}Syx1A06737 No P{PZ}Syx1A10660 No miscellaneous insertions P{5'3'}Syx1A204 NA P{GT1}4EHPBG01713 NA P{PZ-Δ.s2}Syx1A2 NA P{PZ-Δ.s4}Syx1A4 NA P{PZ-Δ.s17}Syx1A17 NA P{PZ-Δ.s118}Syx1A118 NA P{PZ-Δ.s177}Syx1A177 NA P{PZ-Δ.s287}Syx1A287 NA P{PZ-Δ.s294}Syx1A294 NA P{UASp-YFP.Rab3}4EHP05b NA P{wHy}4EHPDG10811 NA PBac{PB}Syx1Ac05841 NA
Gene Ontology: Function, Process & Cellular Component ( 17 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cytokinesis inferred from mutant phenotype (Somma et al., 2002, Echard et al., 2004) haltere development inferred from genetic interaction with Ubx (Pallavi et al., 2006) regulation of pole plasm oskar mRNA localization inferred from mutant phenotype (Ruden et al., 2000) synaptic vesicle fusion to presynaptic membrane inferred from mutant phenotype (Lagow et al., 2007)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay (Khanna et al., 2010)
Terms Based on Predictions or Assertions ( 13 terms )
Molecular Function
CV term Evidence References
SNAP receptor activity inferred from sequence or structural similarity (Littleton, 2000) inferred from sequence or structural similarity with UniProtKB:O35526 (FlyBase Genome Annotators, 2002-2003) non-traceable author statement (Schulze, 1994.11.18, Littleton et al., 1999)
Biological Process
CV term Evidence References
cellularization non-traceable author statement (Tepass et al., 2001) traceable author statement (Mazumdar and Mazumdar, 2002) cuticle development non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) exocytosis non-traceable author statement (Broadie, 1995) intracellular protein transport inferred from electronic annotation with InterPro:IPR006012 (FlyBase Curators et al., 2004-) muscle contraction non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) neurotransmitter secretion non-traceable author statement (Lloyd et al., 2000, Swiss-Prot Project Members, 1997.2.1) synaptic transmission non-traceable author statement (Broadie, 1995) synaptic vesicle docking involved in exocytosis inferred from sequence or structural similarity (Littleton, 2000) inferred from sequence or structural similarity with UniProtKB:O35526 (FlyBase Genome Annotators, 2002-2003) vesicle-mediated transport non-traceable author statement (Lloyd et al., 2000)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity with UniProtKB:O35526 (FlyBase Genome Annotators, 2002-2003) membrane non-traceable author statement (Swiss-Prot Project Members, 1997.2.1) plasma membrane inferred from sequence or structural similarity (Littleton, 2000) non-traceable author statement (Schulze, 1994.11.18, Littleton et al., 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Syx1A allele Gene References Syx1A3-69 Act42A (van Swinderen, 2005) aop (van Swinderen, 2005) CG3760 (van Swinderen, 2005) CG9894 (van Swinderen, 2005) EP2 (van Swinderen, 2005) EP364 (van Swinderen, 2005) EP454 (van Swinderen, 2005) EP704 (van Swinderen, 2005) EP718 (van Swinderen, 2005) EP1244 (van Swinderen, 2005) Etl1 (van Swinderen, 2005) Gmd (van Swinderen, 2005) kis (van Swinderen, 2005) MESR4 (van Swinderen, 2005) Pdk (van Swinderen, 2005) RpS23 (van Swinderen, 2005) Syx1ADN.Scer\UAS coro (Bharathi et al., 2004) Syx1Ahs.PW Csp (Nie et al., 1999) Syx1AL371 Nsf2 (Stewart et al., 2001) Syx1AΔ229 smi26D (Anholt et al., 2003) unspecified bchs (Simonsen et al., 2007) Snap (Babcock et al., 2004) Ubx (Pallavi et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67788 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0013343 DroID - A comprehensive database of gene and protein interactions. • FBgn0013343 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42854
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23231 Dmoj\GI23434 Dper\GL24148 Dpse\GA16036
Curated drosophilid orthologs	Dpse\GA16036
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009304-PA Aedes aegypti (mosquito) AGAP007698-PC Anopheles gambiae (mosquito) XP_393760.3 Apis mellifera (honey bee) XP_001951161.1 Acyrthosiphon pisum (pea aphid) At5g08080.1 Arabidopsis thaliana (wall cress) 25497 Batrachochytrium dendrobatidis (chytrid fungus) 108896 Branchiostoma floridae (lancelet) XP_001898462.1 Brugia malayi (roundworm nematode) BGIBMGA006590-PA Bombyx mori (silk worm) ENSBTAP00000041621 Bos taurus (bovine) CAL0003912 Candida albicans (a form of yeast) CN09305 Caenorhabditis brenneri (small nematode) CBP06543 Caenorhabditis briggsae (nematode) CE16127 Caenorhabditis elegans (worm) ENSCAFP00000018940 Canis familiaris (dog) CAGL0E06160g Candida glabrata (haploid yeast) Chro.20126 Cryptosporidium hominis (obligate parasite) ENSCINP00000028065 Ciona intestinalis (sea squirt) JA15231 Caenorhabditis japonica (nematode) CMI249C Cyanidioschyzon merolae (red alga) cn12265 Cryptococcus neoformans (yeast-like fungus) cgd2_1140 Cryptosporidium parvum (protozoan parasite) CPIJ000184 Culex pipens (mosquito) ENSCPOP00000003060 Cavia porcellus (guinea pig) 113616 Chlamidomonas reinhardtii (green alga) RP42992 Caenorhabditis remanei (nematode) ENSCSAVP00000014167 Ciona savignyi (sedentary tunicate) 110695 Capitella spl (polychaete worm) DDB0233589 Dictyostelium discoideum (amoeba) DEHA2B09570g Debaryomyces Hansenii (yeast) 203416 Daphnia pulex (daphnia) ENSDARP00000076389 Danio rerio (zebra fish) ENSECAP00000021236 Equus caballus (horse) XP_648516 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000013187 Gymnopilus aculeatus (mushroom) ENSGALP00000023410 Gallus gallus (chicken) GL50803_96994 Giardia lamblia (flagellated protozoan) 82302 Hypsipyla robusta (cedar shoot borer) ENSP00000222812 Homo sapiens (human) ISCW023653-PA Ixodes scapularis (deer tick) KLLA0C15961g Kluyveromyces lactis (yeast) 153094 Lottia gigantea (owl limpet) LmjF28.1470 Leishmania major (virus) 17976 Monocosta brevicollis (choanoflagellate) ENSMODP00000002171 Monodelphis domestica (gray opossum) ENSMMUP00000019114 Macaca mulatta (rhesus monkey) ENSMUSP00000005509 Mus musculus (house mouse) 235418 Nematostella vectensis (starlet anemone) XP_001604855.1 Nasonia vitripennis (wasp) ENSOANP00000012750 Ornithorynchus anatinus (platypus) ENSORLP00000025088 Oryzias latipes (japanese killifish) LOC_Os06g39050.1 Oryza sativa (asian rice) 24600 Ostreococcus tauri (green alga) PFB0480w Plasmodium falciparum (protozoal parasite) PHUM002076-PA Pediculus humanus (human body louse) PP21878 Pristionchus pacificus (nematode) 128984 Physcomitrella patens (moss) ENSPPYP00000019613 Pongo pygmaeus (orangutan) 836058 Populus trichocarpa (black cottonwood) ENSPTRP00000013711 Pan troglodytes (chimpanzee) PVX_003985 Plasmodium vivax (protozoal parasite) PVX_253300 Plasmodium vivax (protozoal parasite) ENSRNOP00000040699 Rattus norvegicus (norway rat) 4861192 Sorghum bicolor (sorghum) YMR183C Saccharomyces cerevisiae (budding yeast) Smp_019890 Schistosoma mansoni (trematode parasite) SPCC825.03c Schizosaccharomyces pombe (fission yeast) NP_999785.1 Strongylocentrotus purpuratus (purple sea urchin) 28648 Trichoplax adhaerens (metazoa) TA12025 Theileria annulata (apicomplexan parasite) XP_970205.1 Tribolium castaneum (red flour beetle) Tc00.1047053506587.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506929.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000010535 Tetraodon nigroviridis (green spotted pufferfish) TP02_0230 Theileria parva (parasitic protozoan) 33228 Thalassiosira pseudonana (marine diatom) ENSTRUP00000005147 Takifugu rubripes (pufferfish Takifugu) 3689.m00068 Tetrahymena thermophila (ciliate protozoa) 82578.m00628 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000022761 Xenopus tropicalis (frog) YALI0D25872g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17962 NV14355 LH10984 ISCW023653 JGI_V11_203416 FBgn0076052 FBgn0161738 FBgn0146160 FBgn0100225 CPIJ000184 BGIBMGA006590 ACYPI005967 ACYPI000614 GB19580 AGAP007698 AAEL012657 AAEL009304 PHUM095410 GLEAN_11694
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	25811 y1 v1; P{TRiP.JF01829}attP2 21511 y1 w67c23; P{wHy}4EHPDG10811 Syx1ADG10811 4379 Syx1AΔ229 ry506/TM3, ryRK Sb1 Ser1 11697 ry506 P{PZ}Syx1A06737 4EHP06737/TM3, ryRK Sb1 Ser1
Kyoto	107713 Syx1AΔ229 ry506/TM3, ryRK Sb1 Ser1
VDRC	v33112 w1118; P{GD564}v33112 v33113 w1118; P{GD564}v33113/TM3
Genomic Clones ( 2 )
	BACR15J11 BACR29F06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 77 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD43943
Other clones	DPiM_LD43943 MIP18429
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH19130 GM28941 HL03543 LD41346 RH73222 SD26062
Other clones	7236 34704 61269 82708 97167 99218 108557 144912 153261 164436 176325 176583 280555 280621 524799 524820 528337 557979 CK01.44A.F4 CK01.74A.D12 CK01.75A.H12 CK01.75D.B8 CK01.99D.H12 CK01.116B.F8 CK01.117B.B2 EC38528 EK005628 EK037141 EK058346 EK058962 EK059309 EK059340 EK084464 EK126113 EK144720 EK184735 EK216150 EK219725 EK244950 EK256355 EK281364 EK305355 EK305360 EN05942 EN05963 EN11502 EP21007 FGC019G06 FGH104H09 FGH124A05 FGH124F05 FGM103H01 FGM224H05 FGM234A02 Parral_28_F01 RP004105642 RP004182746 RP004200655 RP004212365 RP004220415 RP004254520 RP004258066 RP004258076 RP004260096 RP004260144 RP004469436 RP004526451 RP004549513
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0013343 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42854
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: syx1A CG5448 (Kodira, 1999.11)
Source for database merge of	Source for merge of: Syx1A anon-EST:Gibbs4 (FlyBase, 1996-) Source for merge of: Syx1A anon-WO02059370.54 (FlyBase, 1996-) Source for merge of: Syx1A CG10716 (FlyBase, 1996-) Source for merge of: syx1A CG18615 (FlyBase, 1996-)
Additional comments	Source for merge of Syx1A anon-EST:Gibbs4 was sequence comparison (date:030707). (FlyBase Genome Annotators, 2002-2003, FlyBase, 1996-) Source for merge of syx1A CG18615 was sequence comparison (date:001104). (FlyBase, 1996-) Source for merge of Syx1A anon-WO02059370.54 was sequence comparison (date:051113). (FlyBase, 1996-) Source for merge of Syx1A CG10716 was a shared cDNA (date:010720). (FlyBase, 1996-)
Other Comments
	dsRNA made from templates generated with primers directed against this gene was tested in an RNAi screen to identify genes that regulate Ca2+ release. (Zhang et al., 2006) dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells. (Echard et al., 2004) Syx1A gene product interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo. (Wu et al., 1999) Rop interacts with Syx1A in vivo. (Wu et al., 1998) The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. (Perrimon et al., 1996) Germline clonal analysis reveals Syx1A is required in the female germline for oocyte development. Syx1A is required for cell viability in the eye, during wing development and plays a role in membranes of the nervous system. (Schulze and Bellen, 1996) Syx1A is absolutely required for spontaneous vesicle fusions, for these events are absent in Syx1A null mutants. However, mature, docked synaptic vesicles are observed by EM at release sites in the presynaptic terminals of Syx1A mutant synapses. Therefore, SYX1A functions downstream of vesicle docking and participates in fusion. (Broadie, 1995) The Syx1A and n-syb proteins function downstream of vesicle docking. (Broadie et al., 1995) Identified and cloned using the monoclonal antibody mAb44D5. The protein is localised in the synaptic areas of the CNS and at neuromuscular junctions. (Cerezo et al., 1995) The Syx1A gene product plays a role in general secretion and is required for exocytosis from a variety of secretory tissues. Syx1A is absolutely required for evoked neuro- transmission as lack of SYX1A entirely abolishes evoked neurotransmitter release. (Schulze et al., 1995, Schulze et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079751 NM_001202347 RefSeq (Proteins) • NP_524475 NP_001189276 DDBJ / EMBL / GenBank • AA697968 AAA75649 AAF56232 AAL29020 ADV37366 AF007164 AI512186 AQ073351 AQ073825 AW943688 AX664480 AY061472 CZ470292 G01403 L37732 Entrez Gene - A searchable database of RefSeq genes. • 42854 UniProtKB/Swiss-Prot • Q24547
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Target SNARE coiled-coil domain (IPR000727) Syntaxin, N-terminal (IPR006011) Syntaxin/epimorphin, conserved site (IPR006012) t-SNARE (IPR010989)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67788 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0013343 DroID - A comprehensive database of gene and protein interactions. • FBgn0013343 DRSC - Results from RNAi screens. • FBgn0013343 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013343 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG33100-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0013343 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42854 InParanoid A subset of ortholog calls from InParanoid. • AAEL009304-PA Aedes aegypti (mosquito) AGAP007698-PC Anopheles gambiae (mosquito) XP_393760.3 Apis mellifera (honey bee) XP_001951161.1 Acyrthosiphon pisum (pea aphid) At5g08080.1 Arabidopsis thaliana (wall cress) 25497 Batrachochytrium dendrobatidis (chytrid fungus) 108896 Branchiostoma floridae (lancelet) XP_001898462.1 Brugia malayi (roundworm nematode) BGIBMGA006590-PA Bombyx mori (silk worm) ENSBTAP00000041621 Bos taurus (bovine) CAL0003912 Candida albicans (a form of yeast) CN09305 Caenorhabditis brenneri (small nematode) CBP06543 Caenorhabditis briggsae (nematode) CE16127 Caenorhabditis elegans (worm) ENSCAFP00000018940 Canis familiaris (dog) CAGL0E06160g Candida glabrata (haploid yeast) Chro.20126 Cryptosporidium hominis (obligate parasite) ENSCINP00000028065 Ciona intestinalis (sea squirt) JA15231 Caenorhabditis japonica (nematode) CMI249C Cyanidioschyzon merolae (red alga) cn12265 Cryptococcus neoformans (yeast-like fungus) cgd2_1140 Cryptosporidium parvum (protozoan parasite) CPIJ000184 Culex pipens (mosquito) ENSCPOP00000003060 Cavia porcellus (guinea pig) 113616 Chlamidomonas reinhardtii (green alga) RP42992 Caenorhabditis remanei (nematode) ENSCSAVP00000014167 Ciona savignyi (sedentary tunicate) 110695 Capitella spl (polychaete worm) DDB0233589 Dictyostelium discoideum (amoeba) DEHA2B09570g Debaryomyces Hansenii (yeast) 203416 Daphnia pulex (daphnia) ENSDARP00000076389 Danio rerio (zebra fish) ENSECAP00000021236 Equus caballus (horse) XP_648516 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000013187 Gymnopilus aculeatus (mushroom) ENSGALP00000023410 Gallus gallus (chicken) GL50803_96994 Giardia lamblia (flagellated protozoan) 82302 Hypsipyla robusta (cedar shoot borer) ENSP00000222812 Homo sapiens (human) ISCW023653-PA Ixodes scapularis (deer tick) KLLA0C15961g Kluyveromyces lactis (yeast) 153094 Lottia gigantea (owl limpet) LmjF28.1470 Leishmania major (virus) 17976 Monocosta brevicollis (choanoflagellate) ENSMODP00000002171 Monodelphis domestica (gray opossum) ENSMMUP00000019114 Macaca mulatta (rhesus monkey) ENSMUSP00000005509 Mus musculus (house mouse) 235418 Nematostella vectensis (starlet anemone) XP_001604855.1 Nasonia vitripennis (wasp) ENSOANP00000012750 Ornithorynchus anatinus (platypus) ENSORLP00000025088 Oryzias latipes (japanese killifish) LOC_Os06g39050.1 Oryza sativa (asian rice) 24600 Ostreococcus tauri (green alga) PFB0480w Plasmodium falciparum (protozoal parasite) PHUM002076-PA Pediculus humanus (human body louse) PP21878 Pristionchus pacificus (nematode) 128984 Physcomitrella patens (moss) ENSPPYP00000019613 Pongo pygmaeus (orangutan) 836058 Populus trichocarpa (black cottonwood) ENSPTRP00000013711 Pan troglodytes (chimpanzee) PVX_003985 Plasmodium vivax (protozoal parasite) PVX_253300 Plasmodium vivax (protozoal parasite) ENSRNOP00000040699 Rattus norvegicus (norway rat) 4861192 Sorghum bicolor (sorghum) YMR183C Saccharomyces cerevisiae (budding yeast) Smp_019890 Schistosoma mansoni (trematode parasite) SPCC825.03c Schizosaccharomyces pombe (fission yeast) NP_999785.1 Strongylocentrotus purpuratus (purple sea urchin) 28648 Trichoplax adhaerens (metazoa) TA12025 Theileria annulata (apicomplexan parasite) XP_970205.1 Tribolium castaneum (red flour beetle) Tc00.1047053506587.60 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053506929.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000010535 Tetraodon nigroviridis (green spotted pufferfish) TP02_0230 Theileria parva (parasitic protozoan) 33228 Thalassiosira pseudonana (marine diatom) ENSTRUP00000005147 Takifugu rubripes (pufferfish Takifugu) 3689.m00068 Tetrahymena thermophila (ciliate protozoa) 82578.m00628 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000022761 Xenopus tropicalis (frog) YALI0D25872g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/syntaxn1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42854 modMine - Data generated by the modENCODE project. • FBgn0013343 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB17962 NV14355 LH10984 ISCW023653 JGI_V11_203416 FBgn0076052 FBgn0161738 FBgn0146160 FBgn0100225 CPIJ000184 BGIBMGA006590 ACYPI005967 ACYPI000614 GB19580 AGAP007698 AAEL012657 AAEL009304 PHUM095410 GLEAN_11694
Synonyms & Secondary IDs ( 41 )
Reported As
Symbol Synonym	anon-EST:Gibbs4   anon-WO02059370.54   CG5448 (Verstreken and Bellen, 2000.9.4, Molnar et al., 2006) CG10716 (Robertson, 2001.5.6, ) CG18615   CG31136 (Perkins et al., 1.15.2009, Khanna et al., 2010) CT30033 (Xie and Ding, 2000) Dm Syx1 (Littleton, 2000) DmSyx1A (McLennan, 2001.5.22) dSyx1 (Xu et al., 2002) l(3)06737   synt (Parfitt et al., 1995) syt-1A (Schulze et al., 1995) Syt1A   syx (Rieckhof et al., 2003, Richmond and Broadie, 2002, Featherstone et al., 2002, Montana and Littleton, 2001, Saitoe et al., 2001, Saitoe et al., 2001, Verstreken and Bellen, 2001, Stewart et al., 2001, Ruden et al., 2000, Nie et al., 1999, Wu et al., 1999, Stowers and Schwarz, 1999, Tolar and Pallanck, 1998, Littleton et al., 1998, Wu et al., 1998, Wu and Bellen, 1997, Burgess et al., 1997, Schulze and Bellen, 1996, Bate and Broadie, 1995, Lagow et al., 2007, Vijayakrishnan et al., 2009, Barber et al., 2009, Cherry and Perrimon, 2004, Kazama et al., 2008, Wang and Chapman, 2010) Syx (Verstreken et al., 2003, Drummond et al., 2001, Phillips et al., 2000, Wu et al., 2000, Hiesinger et al., 2005, Wagh et al., 2006, Stowers and Isacoff, 2007, Zeng et al., 2007, Romero et al., 2008, Baqri et al., 2006, Gilestro et al., 2009, Williamson et al., 2010) syx1 (Littleton, 2000) syx-1 (Schwarz et al., 1995) Syx1 (Garcia-Mata and Burridge, 2007, Matos et al., 2000) Syx1a (Morrison et al., 2008) syx-1A (Bharathi et al., 2004, Schulze, 1994.11.18, Gerst, 1999, Schulze et al., 1995) syx1A (Somma et al., 2002, Mazumdar and Mazumdar, 2002, Somma et al., 2001, Littleton et al., 2001, Hiesinger et al., 2001, Stewart et al., 2000, Niemeyer and Schwarz, 2000, Beaton, 1999.12.12, Xu et al., 1999, Spradling et al., 1999, Prokop, 1999, Littleton et al., 1999, Fergestad et al., 1999, Littleton, 1998.9.16, Angaut-Petit et al., 1998, Broadie et al., 1997, Perrimon et al., 1996, Schulze, 1996.1.24, Broadie et al., 1995, Broadie, 1995, BDGP Project Members, 1994-1999, Babcock et al., 2004) SYX1A (Lloyd et al., 2000) Syx1A (Cho et al., 2005, Pallavi et al., 2006, Zhang et al., 2006, Stuart et al., 2007, Schwarz, 2007.3.20, Coutelis and Ephrussi, 2007, Molnar et al., 2006, van Swinderen and Greenspan, 2003, Kaltenbach et al., 2007, Gallagher and Knoblich, 2006, Peng et al., 2009, Venken et al., 2009, Kim et al., 2005, Williamson et al., 2010) Syx-1A (Gorczyca et al., 2007) SyxA (Zhang et al., 2007)
Name Synonym	Dsyntaxin-1A (Sommer et al., 2005) STX1A (Kaltenbach et al., 2007) syntaxin (Zhen and Jin, 2004, Toonen and Verhage, 2003, Kueppers et al., 2003, Verstreken and Bellen, 2002, Yoshihara and Littleton, 2002, Kavalali, 2002, Vilinsky et al., 2002, Stewart, 2002, Rogat and Miller, 2001, Murthy et al., 2001, Bronk et al., 2001, Nichols and Pelham, 1998, Robinson and Martin, 1998, Wu et al., 1997, Linial and Parnas, 1996, Littleton et al., 1995, Dumstrei et al., 2003, Acharya et al., 2006, Haghnia et al., 2007, Gilestro et al., 2009, Diao et al., 2009, Cherry and Perrimon, 2004, Ratnaparkhi et al., 2008, Matos et al., 2000) Syntaxin (Strickland and Burgess, 2004, Murthy and Schwarz, 2004, Kittel et al., 2006, Wagh et al., 2006, Koh et al., 2007, Pereanu et al., 2007, Hossain et al., 2008, Stowers and Isacoff, 2007, Stewart et al., 2002, Zeng et al., 2007, Snee and Macdonald, 2009) syntaxin-1 (Lecuit, 2003) syntaxin1 (LaLonde et al., 2003, Straight and Field, 2000, Burgess et al., 1997) syntaxin 1 (Finger and White, 2002, Baluska, 2006, Lecuit, 2004) Syntaxin 1 (Khanna et al., 2010, Murthy et al., 2010) Syntaxin1A (Betschinger et al., 2005, Huang et al., 2006, Kaltenbach et al., 2007) syntaxin-1A (Yu, 1997.6.6, Schulze and Bellen, 1996, Sommer et al., 2005, Kazama et al., 2008) Syntaxin-1A (Kuzin et al., 2005, Vijayakrishnan et al., 2009, Gorczyca et al., 2007) Syntaxin 1A (Lagow et al., 2007, Peng et al., 2009, Khanna et al., 2010) syntaxin 1A (Simonsen et al., 2007, Wang and Chapman, 2010, Romero et al., 2008, Franco et al., 2011) syntaxin1A (Goold and Davis, 2007, Pack-Chung et al., 2007) Syntx 1 (Weimbs et al., 1997)
Secondary FlyBase IDs
	FBgn0010900 FBgn0023459 FBgn0039148 FBgn0042210 FBgn0066005
References ( 192 )
Generate a list of	All references relating to this gene ( 192 )
List References by type	Research paper  ( 104 ) Supplementary material  ( 10 ) Review  ( 31 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 19 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 4 ) Curated genome annotation  ( 2 ) Patent  ( 1 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 5 )
	Franco et al., 2011, Mol. Cell. Proteomics 10(5): M110.002188 A Novel Strategy to Isolate Ubiquitin Conjugates Reveals Wide Role for Ubiquitination during Neural Development. [FBrf0213919] Khanna et al., 2010, BMC Genomics 11(1): 302 Towards a membrane proteome in Drosophila: a method for the isolation of plasma membrane. [FBrf0210923] Murthy et al., 2010, Development 137(16): 2773--2783 Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization. [FBrf0211434] Wang and Chapman, 2010, J. Biol. Chem. 285(40): 30759--30766 Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion. [FBrf0211928] Williamson et al., 2010, J. Cell Biol. 189(5): 885--899 A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism in Drosophila melanogaster photoreceptors. [FBrf0210877] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...