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General Information
Symbol
Dmel\Syx1A
Species
D. melanogaster
Name
Syntaxin 1A
Annotation Symbol
CG31136
Feature Type
FlyBase ID
FBgn0013343
Gene Model Status
Stock Availability
Gene Snapshot
Also Known As

syntaxin, syx, syx-1A, Syx1, syntaxin1

Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:24,101,600..24,105,763 [-]
Recombination map

3-83

RefSeq locus
NT_033777 REGION:24101600..24105763
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (25 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
inferred from sequence or structural similarity
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
Biological Process (14 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (10 terms)
CV Term
Evidence
References
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000461524
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
non-traceable author statement
inferred from electronic annotation with InterPro:IPR028669
(assigned by InterPro )
inferred from sequence or structural similarity
inferred from biological aspect of ancestor with PANTHER:PTN000461527
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
non-traceable author statement
Cellular Component (8 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (7 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000461524
(assigned by GO_Central )
inferred from sequence or structural similarity
non-traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000461527
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000461527
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000461349
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000461527
(assigned by GO_Central )
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the syntaxin family. (Q24547)
Summaries
Gene Group (FlyBase)
Qa-SNAREs -
Q-SNAREs are members of the SNARE (soluble N-ethylmaleimide-sensitive factor-attachment protein (SNAP) receptor) family that mediate vesicle-fusion. SNAREs are cytoplasmic, membrane-anchored proteins that contain a 60 amino acid SNARE domain. Three Q-SNAREs domains from the target membrane and one R-SNARE domain from the vesicle interact to form a four four-helix bundle that pulls the two membranes in close proximity and promotes fusion. After fusion, the complexes are dissembled by NSF (N-ethylmaleimide-sensitive factor) and SNAPs (Soluble NSF Attachment Proteins). Q-SNAREs are named from their contribution of a conserved glutamine (Q) residue to the helix bundle. Q-SNARE domains are designated a, b or c, depending on their position within the helix bundle. (Adapted from PMID:15893389 and FBrf0216182).
Protein Function (UniProtKB)
Plays a critical role in several secretory processes, including cuticle secretion and neurotransmitter release, and probably assists in neuronal membrane maturation or the final stages of neuronal differentiation (PubMed:7834751). Essential for embryonic viability and development (PubMed:7834751). Required for coordinated peristaltic contractions (PubMed:7834751). Recruited by Unc-13-4B to secretory lysosome-related organelles (SLs) that are essential for tracheal lumen fusion between previously separate tracheal branches (anastomosis). Possibly promotes the intracellular fusion of the extending tracheal stalk cell lumens in tracheal fusion cells (Fcs) by interacting with complementary SNAREs (such as Syb) present in the apical membrane of the FC-FC interface and the membranes of the separate tracheal stalk cells (PubMed:27323327).
(UniProt, Q24547)
Summary (Interactive Fly)

vesicular docking protein - a t-SNARE - involved in docking and fusion of neurotransmitter-filled vesicles with the presynaptic membrane to release neurotransmitter into the synaptic cleft - organized in nanoclusters that are critical for the docking and priming of secretory vesicles from neurosecretory cells

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Syx1A or the JBrowse view of Dmel\Syx1A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Shares 3' UTR sequences with upstream gene.

Multiphase exon postulated: this gene shares a region of coding sequence with an overlapping gene, but different reading frames are utilized in the overlapping coding region.

Gene model reviewed during 6.04

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0084588
2385
291
FBtr0303161
2639
296
FBtr0392904
4164
291
Additional Transcript Data and Comments
Reported size (kB)

12, 9, 8, 7, 4.4, 3.5 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0083973
33.6
291
5.09
FBpp0292260
34.2
296
5.20
FBpp0352246
33.6
291
5.09
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

291 aa isoforms: Syx1A-PA, Syx1A-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

291 (aa); 35 (kD observed)

Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Syx1A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

In situ hybridization reveals that Syx1A transcripts are present throuhgout precellularized embryos though they are most prevalent at the posterior pole. After cellularization, Syx1A transcripts are present in all cells and appear to be concentrated near the cell membrane. In stage 9 embryos, transcripts are observed in the anterior and posterior midgut invaginations as well as in the ventral neuroblasts and the ectoderm.

Syx1A transcripts are expressed in a complex pattern throughout development. Up to six transcripts are observed at any given stage on northern blots. In early embryos, the 3.5, 4.2, and 8.0kb transcripts are abundant. In 3-9hr embryos, the 4.2, 8.0, and 9.0kb transcripts predominate. The 7.0 and 12.0kb transcripts appear after 9hr. In first instar larvae, 5 transcripts are prominent. In second and third instar larvae, the number of abundant transcripts is reduced to three and two, respectively. During pupation, 5 transcripts reappear and are also seen in adults.

Syx1A expression is widespread in the embryo prior to stage 12. After this, expression in ectodermal cells has faded and expression is observed mainly in the anterior and posterior midguts, the garland cells, and the CNS. By stage 14, the major sites of expression are the CNS and the garland cells. Weaker expression is observed in the PNS.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Syx1A protein is detected in germarium regions 2 and 3 outlining the membranes of the cyst cells. It continues to be abundantly expressed in the nurse cells during oogenesis stages S1-S8. Levels fade during stages S8 and S9. In early embryos, Syx1A protein is present ubiquitously but is concentrated at the posterior tip where it accumulates under the pole buds. At mitotic cycle 13, the protein is concentrated in hexagonal-shaped outlines that correspond to the cleavage furrows of the cytoplasmic buds. After cellularization it is present in all of the membranes of all cells. During germband extension, it is present in the mesoderm, ectoderm, and invaginating neurectoderm but is excluded from the amnioserosa. Syx1A protein is also present in the adult brain and the synaptic substations of the visual system. In the brain it is concentrated in neuropil regions and is somewhat enriched at synaptic regions such as the lamina and the medulla.

Syx1A protein is enriched in neuromuscular junction synaptic boutons, but is also expressed at high levels throughout the axons of the peripheral nerves.

syx1a protein is present primarily in the CNS and garland cells though some staining is seen in the ectoderm and the midgut in stages 15-17. In the CNS, staining is most prominent along the longitudinal tracts of the ventral nerve cord and brain but is also found in the commissures of the CNS and the axons of the peripheral nerves. In the periphery of the embryo, staining is seen in neuromuscular junctions and at low levels in some cell bodies.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Syx1A in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 30 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 25 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Syx1A
Transgenic constructs containing regulatory region of Syx1A
Deletions and Duplications ( 6 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
optic cartridge & synaptic vesicle
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
15 of 15
Yes
Yes
12 of 15
No
Yes
9 of 15
No
Yes
9 of 15
No
Yes
6 of 15
No
Yes
5 of 15
No
Yes
1  
5 of 15
No
Yes
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
15 of 15
Yes
Yes
13 of 15
No
Yes
9 of 15
No
Yes
8 of 15
No
Yes
6 of 15
No
Yes
5 of 15
No
Yes
5 of 15
No
Yes
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (9)
13 of 13
Yes
Yes
12 of 13
No
Yes
9 of 13
No
Yes
9 of 13
No
Yes
5 of 13
No
Yes
4 of 13
No
Yes
2 of 13
No
No
2 of 13
No
Yes
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (8)
13 of 12
Yes
Yes
8 of 12
No
Yes
7 of 12
No
Yes
5 of 12
No
Yes
5 of 12
No
Yes
2 of 12
No
No
2 of 12
No
Yes
1 of 12
No
Yes
Danio rerio (Zebrafish) (11)
13 of 15
Yes
Yes
9 of 15
No
Yes
8 of 15
No
Yes
8 of 15
No
Yes
7 of 15
No
Yes
7 of 15
No
Yes
6 of 15
No
Yes
5 of 15
No
Yes
5 of 15
No
Yes
5 of 15
No
Yes
4 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
15 of 15
Yes
Yes
3 of 15
No
No
3 of 15
No
No
3 of 15
No
No
Arabidopsis thaliana (thale-cress) (10)
7 of 9
Yes
Yes
7 of 9
Yes
Yes
7 of 9
Yes
Yes
7 of 9
Yes
Yes
6 of 9
No
Yes
6 of 9
No
Yes
6 of 9
No
Yes
5 of 9
No
Yes
5 of 9
No
Yes
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
11 of 15
Yes
Yes
10 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
9 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190CYQ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509IP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0BSS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BQJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0EUK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (8)
6 of 10
2 of 10
2 of 10
2 of 10
2 of 10
2 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 4 )
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map

    3-83

    Cytogenetic map
    Sequence location
    3R:24,101,600..24,105,763 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    95E1-95E1
    Limits computationally determined from genome sequence between P{PZ}Atg600096 and P{PZ}Syx1A06737&P{PZ}Syx1A10660
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    95E1-95E2
    (determined by in situ hybridisation)
    Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.
    Experimentally Determined Recombination Data
    Notes

    Syx1A3-69 used in recombination mapping.

    Stocks and Reagents
    Stocks (10)
    Genomic Clones (16)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (77)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Other Information
    Relationship to Other Genes
    Source for database identify of

    Source for identity of: syx1A CG5448

    Source for database merge of

    Source for merge of: syx1A CG18615

    Source for merge of: Syx1A CG10716

    Source for merge of: Syx1A anon-WO02059370.54

    Source for merge of: Syx1A anon- EST:Gibbs4

    Additional comments

    Source for merge of Syx1A anon- EST:Gibbs4 was sequence comparison ( date:030707 ).

    Source for merge of syx1A CG18615 was sequence comparison ( date:001104 ).

    Source for merge of Syx1A anon-WO02059370.54 was sequence comparison ( date:051113 ).

    Source for merge of Syx1A CG10716 was a shared cDNA ( date:010720 ).

    Other Comments

    Syx1A is required for wls protein-containing exosome release at synaptic boutons.

    dsRNA made from templates generated with primers directed against this gene was tested in an RNAi screen to identify genes that regulate Ca2+ release.

    dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.

    Syx1A gene product interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo.

    Rop interacts with Syx1A in vivo.

    The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation.

    Germline clonal analysis reveals Syx1A is required in the female germline for oocyte development. Syx1A is required for cell viability in the eye, during wing development and plays a role in membranes of the nervous system.

    The Syx1A and n-syb proteins function downstream of vesicle docking.

    Syx1A is absolutely required for spontaneous vesicle fusions, for these events are absent in Syx1A null mutants. However, mature, docked synaptic vesicles are observed by EM at release sites in the presynaptic terminals of Syx1A mutant synapses. Therefore, SYX1A functions downstream of vesicle docking and participates in fusion.

    Identified and cloned using the monoclonal antibody mAb44D5. The protein is localised in the synaptic areas of the CNS and at neuromuscular junctions.

    The Syx1A gene product plays a role in general secretion and is required for exocytosis from a variety of secretory tissues. Syx1A is absolutely required for evoked neuro- transmission as lack of SYX1A entirely abolishes evoked neurotransmitter release.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 53 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    Synonyms and Secondary IDs (53)
    Reported As
    Symbol Synonym
    CG18615
    Syt1A
    anon-EST:Gibbs4
    anon-WO02059370.54
    l(3)06737
    Name Synonyms
    Dsyntaxin-1A
    dsyntaxin-1A
    syntaxin-1
    Secondary FlyBase IDs
    • FBgn0010900
    • FBgn0023459
    • FBgn0039148
    • FBgn0042210
    • FBgn0066005
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (292)