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Gene Dmel\TfIIA-S

General Information
Symbol	Dmel\TfIIA-S	Species	D. melanogaster
Name	Transcription-factor-IIA-S	Annotation symbol	CG5163
Feature type	protein_coding_gene	FlyBase ID	FBgn0013347
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	TFIIA, dTFIIA-S
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	95C8-95C8	Sequence location	3R:19,716,110..19,716,782 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Transcription-factor-IIA-S is referred to in FlyBase by the symbol Dmel\TfIIA-S (CG5163, FBgn0013347). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly; RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly. There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; neurogenesis. 14 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R7; eye; trichogen cell; photoreceptor cell; photoreceptor cell R1; photoreceptor cell R6; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Transcription factor IIA, beta-barrel; Transcription factor IIA, helical; Transcription initiation factor IIA, gamma subunit; Transcription initiation factor IIA, gamma subunit, C-terminal; Transcription initiation factor IIA, gamma subunit, N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, larval salivary gland, larval trachea, adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632370_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of TfIIA-S. Gene sequence location is 3R:19716110..19716782.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 95C8-95C8   Limits computationally determined from genome sequence between P{PZ}l(3)0468404684 and P{PZ}Atg600096
Experimentally Determined Cytological Location
Cytogenetic map Notes References 95C6-95C8     (Zeidler, 1994.12.6)
Experimentally Determined Recombination Data
Location	3- (Zeidler, 1994.12.6)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\TfIIA-S for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39 Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) TfIIA-S-RA FBtr0084526  NM_079743   617   106
Additional Transcript Data & Comments
Reported size (kB)	0.6 (longest cDNA) (Yokomori et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein TfIIA-S-PA   FBpp0083912   12.2   106   8.70     NP_524467   AAF56199
Additional Polypeptide Data & Comments
Reported size (kDa)	106 (aa); 12 (kD predicted) (Yokomori et al., 1994) 12.5 (kD predicted) (Bernstein et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Transcription initiation factor IIA, gamma subunit, C-terminal (IPR015871) Transcription initiation factor IIA, gamma subunit, N-terminal (IPR015872) Transcription initiation factor IIA, gamma subunit (IPR003194) Transcription factor IIA, helical (IPR009083) Transcription factor IIA, beta-barrel (IPR009088)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA695560   AA951021   AE014297 AAF56199   AI063405   AY113478 AAM29483   BI357748   BI632002   BP544464   BP544465   BP544763   BP544764   BP546851   BP547251   BP547738   BP547931   BP547973   BP548003   BP548104   BP548183   BP548543   BP550352   BP550353   BP550457   BP551345   BP551346   BP552195   BP552392   BP553678   BP553679   BP553688   BP553689   BP553869   BP553870   BP554771   BP554772   BP555217   BP555218   BP556146   BP556147   BP556711   BP556712   BP557463   BP557464   BP558212   BP558213   BP559029   BP559341   BP559430   BP559589   BP559590   BP560360   BT044069   CO274046   CO306660   CO322110   CO337737   EC198821   EC200494   EC214395   EC232563   EV585109   GH758393   GH758740   GH770677   GH771472   GH771551   GH773870   GH774556   GH780465   GH780810   GH787968   GH790436   GH794341   GH795590   GH798437   GH799499   GH803540   GH804043   GH806088   GH810594   GH814835   GH818148   GH826571   GH826931   GH829009   GH835129   GH836372   GH838833   GH841016   GH843542   GH845197   GH846399   GH851037   GH854623   GH855287   GH856494   GH861232   GH870800   GH871623   GH872102   GH881489   GH882560   GH883571   GH886102   GH887930   GH888017   GH890055   GH890905   GH893134   GH896844   GH897249   GH898404   GH903726   GH909845   GH910495   GH917238   GH919058   GH920307   GH922159   GH922169   GH924059   GH934764   GH938448   X83271 CAA58244
UniProtKB/Swiss-Prot	P52656
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   gonad   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
	TfIIA-S protein is present in embryonic nuclear extracts. (Bernstein et al., 1994)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Yokomori et al., 1994, Bernstein et al., 1994) transcription factor TFIIA complex inferred from direct assay (Yokomori et al., 1994)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, larval salivary gland, larval trachea, adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    768.025 Larval Midgut    262.6 Larval Hindgut    308.9 Larval Malpighian Tubules    494.7 Larval Fat Body    445.2 Larval Salivary Gland    561.9 Larval Trachea    629.5 Larval Carcass    273.925 Adult Head    342.4 Adult Eye    772.875 Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion    447 Adult Crop    399.8 Adult Midgut    381.1 Adult Hindgut    418.1 Adult Malpighian Tubules    181.9 Adult Fat Body    180.2 Adult Salivary Gland    411.7 Adult Heart    486.55 Adult VirginFemale Spermatheca    135.3 Adult InseminatedFemale Spermatheca    122.5 Adult Ovary    518.3 Adult Testis    269.6 Adult Male Accessory Gland    698.3 Adult Carcass    257.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (768.025) Larval Midgut    262.6 Larval Hindgut    308.9 Larval Malpighian Tubules    494.7 Larval Fat Body    445.2 Larval Salivary Gland  (561.9) Larval Trachea  (629.5) Larval Carcass    273.925 Adult Head    342.4 Adult Eye  (772.875) Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion    447 Adult Crop    399.8 Adult Midgut    381.1 Adult Hindgut    418.1 Adult Malpighian Tubules    181.9 Adult Fat Body    180.2 Adult Salivary Gland    411.7 Adult Heart    486.55 Adult VirginFemale Spermatheca    135.3 Adult InseminatedFemale Spermatheca    122.5 Adult Ovary  518.3 Adult Testis    269.6 Adult Male Accessory Gland  (698.3) Adult Carcass    257.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    768.025 Larval Midgut    262.6 Larval Hindgut    308.9 Larval Malpighian Tubules    494.7 Larval Fat Body    445.2 Larval Salivary Gland    561.9 Larval Trachea    629.5 Larval Carcass    273.925 Adult Head    342.4 Adult Eye    772.875 Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion    447 Adult Crop    399.8 Adult Midgut    381.1 Adult Hindgut    418.1 Adult Malpighian Tubules    181.9 Adult Fat Body    180.2 Adult Salivary Gland    411.7 Adult Heart    486.55 Adult VirginFemale Spermatheca    135.3 Adult InseminatedFemale Spermatheca    122.5 Adult Ovary    518.3 Adult Testis    269.6 Adult Male Accessory Gland    698.3 Adult Carcass    257.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    768.025 Larval Midgut    262.6 Larval Hindgut    308.9 Larval Malpighian Tubules    494.7 Larval Fat Body    445.2 Larval Salivary Gland    561.9 Larval Trachea    629.5 Larval Carcass    273.925 Adult Head    342.4 Adult Eye    772.875 Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion    447 Adult Crop    399.8 Adult Midgut    381.1 Adult Hindgut    418.1 Adult Malpighian Tubules    181.9 Adult Fat Body    180.2 Adult Salivary Gland    411.7 Adult Heart    486.55 Adult VirginFemale Spermatheca    135.3 Adult InseminatedFemale Spermatheca    122.5 Adult Ovary    518.3 Adult Testis    269.6 Adult Male Accessory Gland    698.3 Adult Carcass    257.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    768.025 Larval Midgut    262.6 Larval Hindgut    308.9 Larval Malpighian Tubules    494.7 Larval Fat Body    445.2 Larval Salivary Gland    561.9 Larval Trachea    629.5 Larval Carcass    273.925 Adult Head    342.4 Adult Eye    772.875 Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion    447 Adult Crop    399.8 Adult Midgut    381.1 Adult Hindgut    418.1 Adult Malpighian Tubules    181.9 Adult Fat Body    180.2 Adult Salivary Gland    411.7 Adult Heart    486.55 Adult VirginFemale Spermatheca    135.3 Adult InseminatedFemale Spermatheca    122.5 Adult Ovary    518.3 Adult Testis    269.6 Adult Male Accessory Gland    698.3 Adult Carcass    257.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  768.025 Larval Midgut    262.6 Larval Hindgut    308.9 Larval Malpighian Tubules    494.7 Larval Fat Body    445.2 Larval Salivary Gland  561.9 Larval Trachea  629.5 Larval Carcass    273.925 Adult Head    342.4 Adult Eye  772.875 Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion    447 Adult Crop    399.8 Adult Midgut    381.1 Adult Hindgut    418.1 Adult Malpighian Tubules    181.9 Adult Fat Body    180.2 Adult Salivary Gland    411.7 Adult Heart    486.55 Adult VirginFemale Spermatheca    135.3 Adult InseminatedFemale Spermatheca    122.5 Adult Ovary  518.3 Adult Testis    269.6 Adult Male Accessory Gland  698.3 Adult Carcass    257.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    768.025 Larval Midgut    262.6 Larval Hindgut    308.9 Larval Malpighian Tubules    494.7 Larval Fat Body    445.2 Larval Salivary Gland    561.9 Larval Trachea    629.5 Larval Carcass    273.925 Adult Head    342.4 Adult Eye    772.875 Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion    447 Adult Crop    399.8 Adult Midgut    381.1 Adult Hindgut    418.1 Adult Malpighian Tubules    181.9 Adult Fat Body    180.2 Adult Salivary Gland    411.7 Adult Heart    486.55 Adult VirginFemale Spermatheca    135.3 Adult InseminatedFemale Spermatheca    122.5 Adult Ovary    518.3 Adult Testis    269.6 Adult Male Accessory Gland    698.3 Adult Carcass    257.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    768.025 Larval Midgut    262.6 Larval Hindgut    308.9 Larval Malpighian Tubules    494.7 Larval Fat Body    445.2 Larval Salivary Gland    561.9 Larval Trachea    629.5 Larval Carcass    273.925 Adult Head    342.4 Adult Eye    772.875 Adult Brain    449.3 Adult Thoracic-Abdominal Ganglion    447 Adult Crop    399.8 Adult Midgut    381.1 Adult Hindgut    418.1 Adult Malpighian Tubules    181.9 Adult Fat Body    180.2 Adult Salivary Gland    411.7 Adult Heart    486.55 Adult VirginFemale Spermatheca    135.3 Adult InseminatedFemale Spermatheca    122.5 Adult Ovary    518.3 Adult Testis    269.6 Adult Male Accessory Gland    698.3 Adult Carcass    257.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    342.4   NA  Eye    772.875   NA  Brain    449.3   768.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    447   NA  Crop    399.8   262.6  Midgut    381.1   308.9  Hindgut    418.1   494.7  Malpighian Tubules    181.9   445.2  Fat Body    180.2   561.9  Salivary Gland    411.7   NA  Heart    486.55   629.5  Trachea    NA   NA  VirginFemale Spermatheca    135.3   NA  InseminatedFemale Spermatheca    122.5   NA  Ovary    518.3   NA  Testis    269.6   NA  Male Accessory Gland    698.3   273.925  Carcass    257.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    272 central nervous system, larvae L3    267 central nervous system, pupae P8    135 head, virgin 1-day female    96 head, virgin 4-day female    104 head, virgin 20-day female    87 head, mated 1-day female    112 head, mated 4-day female    95 head, mated 20-day female    92 head, mated 1-day male    148 head, mated 4-day male    126 head, mated 20-day male    152 salivary gland, larvae L3 wandering    126 salivary gland, white prepupae    229 digestive system, larvae L3 wandering    180 digestive system, 1-day adult    84 digestive system, 4-day adult    99 digestive system, 20-day adult    74 fat body, larvae L3 wandering    67 fat body, white prepupae    127 fat body, pupae P8    241 carcass, larvae L3 wandering    204 carcass, 1-day adult    80 carcass, 4-day adult    83 carcass, 20-day adult    104 ovary, virgin 4-day female    228 ovary, mated 4-day female    218 testis, mated 4-day male    217 accessory gland, mated 4-day male    119 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (272) central nervous system, larvae L3  (267) central nervous system, pupae P8  (135) head, virgin 1-day female  (96) head, virgin 4-day female  (104) head, virgin 20-day female  (87) head, mated 1-day female  (112) head, mated 4-day female  (95) head, mated 20-day female  (92) head, mated 1-day male  (148) head, mated 4-day male  (126) head, mated 20-day male  (152) salivary gland, larvae L3 wandering  (126) salivary gland, white prepupae  (229) digestive system, larvae L3 wandering  (180) digestive system, 1-day adult  (84) digestive system, 4-day adult  (99) digestive system, 20-day adult  (74) fat body, larvae L3 wandering  (67) fat body, white prepupae  (127) fat body, pupae P8  (241) carcass, larvae L3 wandering  (204) carcass, 1-day adult  (80) carcass, 4-day adult  (83) carcass, 20-day adult  (104) ovary, virgin 4-day female  (228) ovary, mated 4-day female  (218) testis, mated 4-day male  (217) accessory gland, mated 4-day male  (119) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (272) central nervous system, larvae L3  (267) central nervous system, pupae P8  (135) head, virgin 1-day female    96 head, virgin 4-day female  104 head, virgin 20-day female    87 head, mated 1-day female  (112) head, mated 4-day female    95 head, mated 20-day female    92 head, mated 1-day male  (148) head, mated 4-day male  (126) head, mated 20-day male  (152) salivary gland, larvae L3 wandering  (126) salivary gland, white prepupae  (229) digestive system, larvae L3 wandering  (180) digestive system, 1-day adult    84 digestive system, 4-day adult    99 digestive system, 20-day adult    74 fat body, larvae L3 wandering    67 fat body, white prepupae  (127) fat body, pupae P8  (241) carcass, larvae L3 wandering  (204) carcass, 1-day adult    80 carcass, 4-day adult    83 carcass, 20-day adult  104 ovary, virgin 4-day female  (228) ovary, mated 4-day female  (218) testis, mated 4-day male  (217) accessory gland, mated 4-day male  (119) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    272 central nervous system, larvae L3    267 central nervous system, pupae P8    135 head, virgin 1-day female    96 head, virgin 4-day female    104 head, virgin 20-day female    87 head, mated 1-day female    112 head, mated 4-day female    95 head, mated 20-day female    92 head, mated 1-day male    148 head, mated 4-day male    126 head, mated 20-day male    152 salivary gland, larvae L3 wandering    126 salivary gland, white prepupae    229 digestive system, larvae L3 wandering    180 digestive system, 1-day adult    84 digestive system, 4-day adult    99 digestive system, 20-day adult    74 fat body, larvae L3 wandering    67 fat body, white prepupae    127 fat body, pupae P8    241 carcass, larvae L3 wandering    204 carcass, 1-day adult    80 carcass, 4-day adult    83 carcass, 20-day adult    104 ovary, virgin 4-day female    228 ovary, mated 4-day female    218 testis, mated 4-day male    217 accessory gland, mated 4-day male    119 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    272 central nervous system, larvae L3    267 central nervous system, pupae P8    135 head, virgin 1-day female    96 head, virgin 4-day female    104 head, virgin 20-day female    87 head, mated 1-day female    112 head, mated 4-day female    95 head, mated 20-day female    92 head, mated 1-day male    148 head, mated 4-day male    126 head, mated 20-day male    152 salivary gland, larvae L3 wandering    126 salivary gland, white prepupae    229 digestive system, larvae L3 wandering    180 digestive system, 1-day adult    84 digestive system, 4-day adult    99 digestive system, 20-day adult    74 fat body, larvae L3 wandering    67 fat body, white prepupae    127 fat body, pupae P8    241 carcass, larvae L3 wandering    204 carcass, 1-day adult    80 carcass, 4-day adult    83 carcass, 20-day adult    104 ovary, virgin 4-day female    228 ovary, mated 4-day female    218 testis, mated 4-day male    217 accessory gland, mated 4-day male    119 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (272) central nervous system, larvae L3  (267) central nervous system, pupae P8  (135) head, virgin 1-day female  (96) head, virgin 4-day female  (104) head, virgin 20-day female  (87) head, mated 1-day female  (112) head, mated 4-day female  (95) head, mated 20-day female  (92) head, mated 1-day male  (148) head, mated 4-day male  (126) head, mated 20-day male  (152) salivary gland, larvae L3 wandering  (126) salivary gland, white prepupae  (229) digestive system, larvae L3 wandering  (180) digestive system, 1-day adult  (84) digestive system, 4-day adult  (99) digestive system, 20-day adult  (74) fat body, larvae L3 wandering  (67) fat body, white prepupae  (127) fat body, pupae P8  (241) carcass, larvae L3 wandering  (204) carcass, 1-day adult  (80) carcass, 4-day adult  (83) carcass, 20-day adult  (104) ovary, virgin 4-day female  (228) ovary, mated 4-day female  (218) testis, mated 4-day male  (217) accessory gland, mated 4-day male  (119) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (272) central nervous system, larvae L3  (267) central nervous system, pupae P8  135 head, virgin 1-day female    96 head, virgin 4-day female  104 head, virgin 20-day female    87 head, mated 1-day female  112 head, mated 4-day female    95 head, mated 20-day female    92 head, mated 1-day male  (148) head, mated 4-day male  126 head, mated 20-day male  (152) salivary gland, larvae L3 wandering  126 salivary gland, white prepupae  (229) digestive system, larvae L3 wandering  (180) digestive system, 1-day adult    84 digestive system, 4-day adult    99 digestive system, 20-day adult    74 fat body, larvae L3 wandering    67 fat body, white prepupae  127 fat body, pupae P8  (241) carcass, larvae L3 wandering  (204) carcass, 1-day adult    80 carcass, 4-day adult    83 carcass, 20-day adult  104 ovary, virgin 4-day female  (228) ovary, mated 4-day female  (218) testis, mated 4-day male  (217) accessory gland, mated 4-day male  119 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    272 central nervous system, larvae L3    267 central nervous system, pupae P8    135 head, virgin 1-day female    96 head, virgin 4-day female    104 head, virgin 20-day female    87 head, mated 1-day female    112 head, mated 4-day female    95 head, mated 20-day female    92 head, mated 1-day male    148 head, mated 4-day male    126 head, mated 20-day male    152 salivary gland, larvae L3 wandering    126 salivary gland, white prepupae    229 digestive system, larvae L3 wandering    180 digestive system, 1-day adult    84 digestive system, 4-day adult    99 digestive system, 20-day adult    74 fat body, larvae L3 wandering    67 fat body, white prepupae    127 fat body, pupae P8    241 carcass, larvae L3 wandering    204 carcass, 1-day adult    80 carcass, 4-day adult    83 carcass, 20-day adult    104 ovary, virgin 4-day female    228 ovary, mated 4-day female    218 testis, mated 4-day male    217 accessory gland, mated 4-day male    119 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    147 embryo 02-04hr    278 embryo 04-06hr    367 embryo 06-08hr    290 embryo 08-10hr    256 embryo 10-12hr    226 embryo 12-14hr    153 embryo 14-16hr    132 embryo 16-18hr    117 embryo 18-20hr    97 embryo 20-22hr    81 embryo 22-24hr    84 larva L1    61 larva L2    48 larva L3 12hr old    45 larva L3 puffstage 1-2    81 larva L3 puffstage 3-6    96 larva L3 puffstage 7-9    114 white prepupae new    104 white prepupae 12hr    95 white prepupae 24hr    116 pupae 2d postWPP    105 pupae 3d postWPP    73 pupae 4d postWPP    65 adult male 01day    57 adult male 05day    66 adult male 30day    69 adult female 01day    83 adult female 05day    87 adult female 30day    90 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (147) embryo 02-04hr  (278) embryo 04-06hr  (367) embryo 06-08hr  (290) embryo 08-10hr  (256) embryo 10-12hr  (226) embryo 12-14hr  (153) embryo 14-16hr  (132) embryo 16-18hr  (117) embryo 18-20hr  (97) embryo 20-22hr  (81) embryo 22-24hr  (84) larva L1  (61) larva L2  (48) larva L3 12hr old  (45) larva L3 puffstage 1-2  (81) larva L3 puffstage 3-6  (96) larva L3 puffstage 7-9  (114) white prepupae new  (104) white prepupae 12hr  (95) white prepupae 24hr  (116) pupae 2d postWPP  (105) pupae 3d postWPP  (73) pupae 4d postWPP  (65) adult male 01day  (57) adult male 05day  (66) adult male 30day  (69) adult female 01day  (83) adult female 05day  (87) adult female 30day  (90) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (147) embryo 02-04hr  (278) embryo 04-06hr  (367) embryo 06-08hr  (290) embryo 08-10hr  (256) embryo 10-12hr  (226) embryo 12-14hr  (153) embryo 14-16hr  (132) embryo 16-18hr  (117) embryo 18-20hr    97 embryo 20-22hr    81 embryo 22-24hr    84 larva L1    61 larva L2    48 larva L3 12hr old    45 larva L3 puffstage 1-2    81 larva L3 puffstage 3-6    96 larva L3 puffstage 7-9  (114) white prepupae new  104 white prepupae 12hr    95 white prepupae 24hr  (116) pupae 2d postWPP  105 pupae 3d postWPP    73 pupae 4d postWPP    65 adult male 01day    57 adult male 05day    66 adult male 30day    69 adult female 01day    83 adult female 05day    87 adult female 30day    90 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    147 embryo 02-04hr    278 embryo 04-06hr    367 embryo 06-08hr    290 embryo 08-10hr    256 embryo 10-12hr    226 embryo 12-14hr    153 embryo 14-16hr    132 embryo 16-18hr    117 embryo 18-20hr    97 embryo 20-22hr    81 embryo 22-24hr    84 larva L1    61 larva L2    48 larva L3 12hr old    45 larva L3 puffstage 1-2    81 larva L3 puffstage 3-6    96 larva L3 puffstage 7-9    114 white prepupae new    104 white prepupae 12hr    95 white prepupae 24hr    116 pupae 2d postWPP    105 pupae 3d postWPP    73 pupae 4d postWPP    65 adult male 01day    57 adult male 05day    66 adult male 30day    69 adult female 01day    83 adult female 05day    87 adult female 30day    90 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    147 embryo 02-04hr    278 embryo 04-06hr    367 embryo 06-08hr    290 embryo 08-10hr    256 embryo 10-12hr    226 embryo 12-14hr    153 embryo 14-16hr    132 embryo 16-18hr    117 embryo 18-20hr    97 embryo 20-22hr    81 embryo 22-24hr    84 larva L1    61 larva L2    48 larva L3 12hr old    45 larva L3 puffstage 1-2    81 larva L3 puffstage 3-6    96 larva L3 puffstage 7-9    114 white prepupae new    104 white prepupae 12hr    95 white prepupae 24hr    116 pupae 2d postWPP    105 pupae 3d postWPP    73 pupae 4d postWPP    65 adult male 01day    57 adult male 05day    66 adult male 30day    69 adult female 01day    83 adult female 05day    87 adult female 30day    90 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (147) embryo 02-04hr  (278) embryo 04-06hr  (367) embryo 06-08hr  (290) embryo 08-10hr  (256) embryo 10-12hr  (226) embryo 12-14hr  (153) embryo 14-16hr  (132) embryo 16-18hr  (117) embryo 18-20hr  (97) embryo 20-22hr  (81) embryo 22-24hr  (84) larva L1  (61) larva L2  (48) larva L3 12hr old  (45) larva L3 puffstage 1-2  (81) larva L3 puffstage 3-6  (96) larva L3 puffstage 7-9  (114) white prepupae new  (104) white prepupae 12hr  (95) white prepupae 24hr  (116) pupae 2d postWPP  (105) pupae 3d postWPP  (73) pupae 4d postWPP  (65) adult male 01day  (57) adult male 05day  (66) adult male 30day  (69) adult female 01day  (83) adult female 05day  (87) adult female 30day  (90) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (147) embryo 02-04hr  (278) embryo 04-06hr  (367) embryo 06-08hr  (290) embryo 08-10hr  (256) embryo 10-12hr  (226) embryo 12-14hr  (153) embryo 14-16hr  132 embryo 16-18hr  117 embryo 18-20hr    97 embryo 20-22hr    81 embryo 22-24hr    84 larva L1    61 larva L2    48 larva L3 12hr old    45 larva L3 puffstage 1-2    81 larva L3 puffstage 3-6    96 larva L3 puffstage 7-9  114 white prepupae new  104 white prepupae 12hr    95 white prepupae 24hr  116 pupae 2d postWPP  105 pupae 3d postWPP    73 pupae 4d postWPP    65 adult male 01day    57 adult male 05day    66 adult male 30day    69 adult female 01day    83 adult female 05day    87 adult female 30day    90 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    147 embryo 02-04hr    278 embryo 04-06hr    367 embryo 06-08hr    290 embryo 08-10hr    256 embryo 10-12hr    226 embryo 12-14hr    153 embryo 14-16hr    132 embryo 16-18hr    117 embryo 18-20hr    97 embryo 20-22hr    81 embryo 22-24hr    84 larva L1    61 larva L2    48 larva L3 12hr old    45 larva L3 puffstage 1-2    81 larva L3 puffstage 3-6    96 larva L3 puffstage 7-9    114 white prepupae new    104 white prepupae 12hr    95 white prepupae 24hr    116 pupae 2d postWPP    105 pupae 3d postWPP    73 pupae 4d postWPP    65 adult male 01day    57 adult male 05day    66 adult male 30day    69 adult female 01day    83 adult female 05day    87 adult female 30day    90 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    267 Schneider line 2 Sg4    168 embryonic 1182-4H    250 embryonic GM2    142 embryonic Kc167    107 embryonic S1    382 embryonic S3    150 leg disc CME L1    327 wing disc CME-W2    189 wing disc ML-DmD8    135 wing disc ML-DmD9    238 wing disc ML-DmD16-c3    372 wing disc ML-DmD21    473 wing disc ML-DmD32    396 haltere disc ML-DmD17-c3    195 eye-antennal disc ML-DmD11    226 antennal disc ML-DmD20-c5    241 mixed discs ML-DmD4-c1    157 CNS ML-DmBG1-c1    489 CNS ML-DmBG2-c2    156 tumorous blood cells mbn2    115 ovary fGS/OSS    465 ovary OSC    993 ovary OSS    210 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (267) Schneider line 2 Sg4  (168) embryonic 1182-4H  (250) embryonic GM2  (142) embryonic Kc167  (107) embryonic S1  (382) embryonic S3  (150) leg disc CME L1  (327) wing disc CME-W2  (189) wing disc ML-DmD8  (135) wing disc ML-DmD9  (238) wing disc ML-DmD16-c3  (372) wing disc ML-DmD21  (473) wing disc ML-DmD32  (396) haltere disc ML-DmD17-c3  (195) eye-antennal disc ML-DmD11  (226) antennal disc ML-DmD20-c5  (241) mixed discs ML-DmD4-c1  (157) CNS ML-DmBG1-c1  (489) CNS ML-DmBG2-c2  (156) tumorous blood cells mbn2  (115) ovary fGS/OSS  (465) ovary OSC  (993) ovary OSS  (210) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (267) Schneider line 2 Sg4  (168) embryonic 1182-4H  (250) embryonic GM2  (142) embryonic Kc167  107 embryonic S1  (382) embryonic S3  (150) leg disc CME L1  (327) wing disc CME-W2  (189) wing disc ML-DmD8  (135) wing disc ML-DmD9  (238) wing disc ML-DmD16-c3  (372) wing disc ML-DmD21  (473) wing disc ML-DmD32  (396) haltere disc ML-DmD17-c3  (195) eye-antennal disc ML-DmD11  (226) antennal disc ML-DmD20-c5  (241) mixed discs ML-DmD4-c1  (157) CNS ML-DmBG1-c1  (489) CNS ML-DmBG2-c2  (156) tumorous blood cells mbn2  (115) ovary fGS/OSS  (465) ovary OSC  (993) ovary OSS  (210) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    267 Schneider line 2 Sg4    168 embryonic 1182-4H    250 embryonic GM2    142 embryonic Kc167    107 embryonic S1    382 embryonic S3    150 leg disc CME L1    327 wing disc CME-W2    189 wing disc ML-DmD8    135 wing disc ML-DmD9    238 wing disc ML-DmD16-c3    372 wing disc ML-DmD21    473 wing disc ML-DmD32    396 haltere disc ML-DmD17-c3    195 eye-antennal disc ML-DmD11    226 antennal disc ML-DmD20-c5    241 mixed discs ML-DmD4-c1    157 CNS ML-DmBG1-c1    489 CNS ML-DmBG2-c2    156 tumorous blood cells mbn2    115 ovary fGS/OSS    465 ovary OSC    993 ovary OSS    210 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    267 Schneider line 2 Sg4    168 embryonic 1182-4H    250 embryonic GM2    142 embryonic Kc167    107 embryonic S1    382 embryonic S3    150 leg disc CME L1    327 wing disc CME-W2    189 wing disc ML-DmD8    135 wing disc ML-DmD9    238 wing disc ML-DmD16-c3    372 wing disc ML-DmD21    473 wing disc ML-DmD32    396 haltere disc ML-DmD17-c3    195 eye-antennal disc ML-DmD11    226 antennal disc ML-DmD20-c5    241 mixed discs ML-DmD4-c1    157 CNS ML-DmBG1-c1    489 CNS ML-DmBG2-c2    156 tumorous blood cells mbn2    115 ovary fGS/OSS    465 ovary OSC    993 ovary OSS    210 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (267) Schneider line 2 Sg4  (168) embryonic 1182-4H  (250) embryonic GM2  (142) embryonic Kc167  (107) embryonic S1  (382) embryonic S3  (150) leg disc CME L1  (327) wing disc CME-W2  (189) wing disc ML-DmD8  (135) wing disc ML-DmD9  (238) wing disc ML-DmD16-c3  (372) wing disc ML-DmD21  (473) wing disc ML-DmD32  (396) haltere disc ML-DmD17-c3  (195) eye-antennal disc ML-DmD11  (226) antennal disc ML-DmD20-c5  (241) mixed discs ML-DmD4-c1  (157) CNS ML-DmBG1-c1  (489) CNS ML-DmBG2-c2  (156) tumorous blood cells mbn2  (115) ovary fGS/OSS  (465) ovary OSC  (993) ovary OSS  (210) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (267) Schneider line 2 Sg4  (168) embryonic 1182-4H  (250) embryonic GM2  142 embryonic Kc167  107 embryonic S1  (382) embryonic S3  (150) leg disc CME L1  (327) wing disc CME-W2  (189) wing disc ML-DmD8  135 wing disc ML-DmD9  (238) wing disc ML-DmD16-c3  (372) wing disc ML-DmD21  (473) wing disc ML-DmD32  (396) haltere disc ML-DmD17-c3  (195) eye-antennal disc ML-DmD11  (226) antennal disc ML-DmD20-c5  (241) mixed discs ML-DmD4-c1  (157) CNS ML-DmBG1-c1  (489) CNS ML-DmBG2-c2  (156) tumorous blood cells mbn2  115 ovary fGS/OSS  (465) ovary OSC  (993) ovary OSS  (210) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    267 Schneider line 2 Sg4    168 embryonic 1182-4H    250 embryonic GM2    142 embryonic Kc167    107 embryonic S1    382 embryonic S3    150 leg disc CME L1    327 wing disc CME-W2    189 wing disc ML-DmD8    135 wing disc ML-DmD9    238 wing disc ML-DmD16-c3    372 wing disc ML-DmD21    473 wing disc ML-DmD32    396 haltere disc ML-DmD17-c3    195 eye-antennal disc ML-DmD11    226 antennal disc ML-DmD20-c5    241 mixed discs ML-DmD4-c1    157 CNS ML-DmBG1-c1    489 CNS ML-DmBG2-c2    156 tumorous blood cells mbn2    115 ovary fGS/OSS    465 ovary OSC    993 ovary OSS    210 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    138 cold shock, 4-day adult    84 heat shock, 4-day adult    113 Cadmium 50 mM 6 hrs, larvae L3    114 Cadmium 50 mM 12 hrs, larvae L3    176 Cadmium 50 mM 48 hrs, 4-day adult    108 Cadmium 100 mM 48 hrs, 4-day adult    186 Copper 0.5 mM 12 hrs, larvae L3    141 Copper 15 mM 48 hrs, 4-day adult    101 Zinc 5 mM 12 hrs, larvae L3    109 Zinc 4.5 mM 48 hrs, 4-day adult    127 Ethanol 2.5% 3 hrs, larvae L3    162 Ethanol 5% 3 hrs, larvae L3    111 Ethanol 10% 3 hrs, larvae L3    91 Caffeine 1.5 mg/ml 4 hrs, larvae L3    103 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    207 Caffeine 25 mg/ml 48 hrs, 4-day adult    93 Paraquat 5 mM 48 hrs, 4-day adult    182 Paraquat 10 mM 48 hrs, 4-day adult    141 Rotenone 2 μg 12 hrs, larvae L3    99 Rotenone 8 μg 12 hrs, larvae L3    117 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (138) cold shock, 4-day adult  (84) heat shock, 4-day adult  (113) Cadmium 50 mM 6 hrs, larvae L3  (114) Cadmium 50 mM 12 hrs, larvae L3  (176) Cadmium 50 mM 48 hrs, 4-day adult  (108) Cadmium 100 mM 48 hrs, 4-day adult  (186) Copper 0.5 mM 12 hrs, larvae L3  (141) Copper 15 mM 48 hrs, 4-day adult  (101) Zinc 5 mM 12 hrs, larvae L3  (109) Zinc 4.5 mM 48 hrs, 4-day adult  (127) Ethanol 2.5% 3 hrs, larvae L3  (162) Ethanol 5% 3 hrs, larvae L3  (111) Ethanol 10% 3 hrs, larvae L3  (91) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (103) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (207) Caffeine 25 mg/ml 48 hrs, 4-day adult  (93) Paraquat 5 mM 48 hrs, 4-day adult  (182) Paraquat 10 mM 48 hrs, 4-day adult  (141) Rotenone 2 μg 12 hrs, larvae L3  (99) Rotenone 8 μg 12 hrs, larvae L3  (117) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (138) cold shock, 4-day adult    84 heat shock, 4-day adult  (113) Cadmium 50 mM 6 hrs, larvae L3  (114) Cadmium 50 mM 12 hrs, larvae L3  (176) Cadmium 50 mM 48 hrs, 4-day adult  (108) Cadmium 100 mM 48 hrs, 4-day adult  (186) Copper 0.5 mM 12 hrs, larvae L3  (141) Copper 15 mM 48 hrs, 4-day adult  101 Zinc 5 mM 12 hrs, larvae L3  (109) Zinc 4.5 mM 48 hrs, 4-day adult  (127) Ethanol 2.5% 3 hrs, larvae L3  (162) Ethanol 5% 3 hrs, larvae L3  (111) Ethanol 10% 3 hrs, larvae L3    91 Caffeine 1.5 mg/ml 4 hrs, larvae L3  103 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (207) Caffeine 25 mg/ml 48 hrs, 4-day adult    93 Paraquat 5 mM 48 hrs, 4-day adult  (182) Paraquat 10 mM 48 hrs, 4-day adult  (141) Rotenone 2 μg 12 hrs, larvae L3    99 Rotenone 8 μg 12 hrs, larvae L3  (117) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    138 cold shock, 4-day adult    84 heat shock, 4-day adult    113 Cadmium 50 mM 6 hrs, larvae L3    114 Cadmium 50 mM 12 hrs, larvae L3    176 Cadmium 50 mM 48 hrs, 4-day adult    108 Cadmium 100 mM 48 hrs, 4-day adult    186 Copper 0.5 mM 12 hrs, larvae L3    141 Copper 15 mM 48 hrs, 4-day adult    101 Zinc 5 mM 12 hrs, larvae L3    109 Zinc 4.5 mM 48 hrs, 4-day adult    127 Ethanol 2.5% 3 hrs, larvae L3    162 Ethanol 5% 3 hrs, larvae L3    111 Ethanol 10% 3 hrs, larvae L3    91 Caffeine 1.5 mg/ml 4 hrs, larvae L3    103 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    207 Caffeine 25 mg/ml 48 hrs, 4-day adult    93 Paraquat 5 mM 48 hrs, 4-day adult    182 Paraquat 10 mM 48 hrs, 4-day adult    141 Rotenone 2 μg 12 hrs, larvae L3    99 Rotenone 8 μg 12 hrs, larvae L3    117 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    138 cold shock, 4-day adult    84 heat shock, 4-day adult    113 Cadmium 50 mM 6 hrs, larvae L3    114 Cadmium 50 mM 12 hrs, larvae L3    176 Cadmium 50 mM 48 hrs, 4-day adult    108 Cadmium 100 mM 48 hrs, 4-day adult    186 Copper 0.5 mM 12 hrs, larvae L3    141 Copper 15 mM 48 hrs, 4-day adult    101 Zinc 5 mM 12 hrs, larvae L3    109 Zinc 4.5 mM 48 hrs, 4-day adult    127 Ethanol 2.5% 3 hrs, larvae L3    162 Ethanol 5% 3 hrs, larvae L3    111 Ethanol 10% 3 hrs, larvae L3    91 Caffeine 1.5 mg/ml 4 hrs, larvae L3    103 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    207 Caffeine 25 mg/ml 48 hrs, 4-day adult    93 Paraquat 5 mM 48 hrs, 4-day adult    182 Paraquat 10 mM 48 hrs, 4-day adult    141 Rotenone 2 μg 12 hrs, larvae L3    99 Rotenone 8 μg 12 hrs, larvae L3    117 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (138) cold shock, 4-day adult  (84) heat shock, 4-day adult  (113) Cadmium 50 mM 6 hrs, larvae L3  (114) Cadmium 50 mM 12 hrs, larvae L3  (176) Cadmium 50 mM 48 hrs, 4-day adult  (108) Cadmium 100 mM 48 hrs, 4-day adult  (186) Copper 0.5 mM 12 hrs, larvae L3  (141) Copper 15 mM 48 hrs, 4-day adult  (101) Zinc 5 mM 12 hrs, larvae L3  (109) Zinc 4.5 mM 48 hrs, 4-day adult  (127) Ethanol 2.5% 3 hrs, larvae L3  (162) Ethanol 5% 3 hrs, larvae L3  (111) Ethanol 10% 3 hrs, larvae L3  (91) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (103) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (207) Caffeine 25 mg/ml 48 hrs, 4-day adult  (93) Paraquat 5 mM 48 hrs, 4-day adult  (182) Paraquat 10 mM 48 hrs, 4-day adult  (141) Rotenone 2 μg 12 hrs, larvae L3  (99) Rotenone 8 μg 12 hrs, larvae L3  (117) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  138 cold shock, 4-day adult    84 heat shock, 4-day adult  113 Cadmium 50 mM 6 hrs, larvae L3  114 Cadmium 50 mM 12 hrs, larvae L3  (176) Cadmium 50 mM 48 hrs, 4-day adult  108 Cadmium 100 mM 48 hrs, 4-day adult  (186) Copper 0.5 mM 12 hrs, larvae L3  141 Copper 15 mM 48 hrs, 4-day adult  101 Zinc 5 mM 12 hrs, larvae L3  109 Zinc 4.5 mM 48 hrs, 4-day adult  127 Ethanol 2.5% 3 hrs, larvae L3  (162) Ethanol 5% 3 hrs, larvae L3  111 Ethanol 10% 3 hrs, larvae L3    91 Caffeine 1.5 mg/ml 4 hrs, larvae L3  103 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (207) Caffeine 25 mg/ml 48 hrs, 4-day adult    93 Paraquat 5 mM 48 hrs, 4-day adult  (182) Paraquat 10 mM 48 hrs, 4-day adult  141 Rotenone 2 μg 12 hrs, larvae L3    99 Rotenone 8 μg 12 hrs, larvae L3  117 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    138 cold shock, 4-day adult    84 heat shock, 4-day adult    113 Cadmium 50 mM 6 hrs, larvae L3    114 Cadmium 50 mM 12 hrs, larvae L3    176 Cadmium 50 mM 48 hrs, 4-day adult    108 Cadmium 100 mM 48 hrs, 4-day adult    186 Copper 0.5 mM 12 hrs, larvae L3    141 Copper 15 mM 48 hrs, 4-day adult    101 Zinc 5 mM 12 hrs, larvae L3    109 Zinc 4.5 mM 48 hrs, 4-day adult    127 Ethanol 2.5% 3 hrs, larvae L3    162 Ethanol 5% 3 hrs, larvae L3    111 Ethanol 10% 3 hrs, larvae L3    91 Caffeine 1.5 mg/ml 4 hrs, larvae L3    103 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    207 Caffeine 25 mg/ml 48 hrs, 4-day adult    93 Paraquat 5 mM 48 hrs, 4-day adult    182 Paraquat 10 mM 48 hrs, 4-day adult    141 Rotenone 2 μg 12 hrs, larvae L3    99 Rotenone 8 μg 12 hrs, larvae L3    117 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • FI01012 RE44302 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013347 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5163-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for TfIIA-S Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal TfIIA-SGD4733 lethal | embryonic stage | recessive TfIIA-SE32 lethal | pharate adult stage | recessive TfIIA-SE73 partially lethal - majority die, with Scer\GAL429BD TfIIA-SGS97 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 TfIIA-SGD4733 Other Phenotypes Allele neuroanatomy defective | larval stage TfIIA-SGD4733 visible, with Scer\GAL429BD TfIIA-SGS97 visible, with Scer\GAL4c355 TfIIA-SGS97 visible, with Scer\GAL4pnr-MD237 TfIIA-SGD4733 wild-type TfIIA-S+t4 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage TfIIA-SGD4733 eye TfIIA-SE73 eye, with Scer\GAL429BD TfIIA-SGS97 eye, with Scer\GAL4c355 TfIIA-SGS97 ganglion mother cell | larval stage TfIIA-SGD4733 mesothoracic tergum, with Scer\GAL4pnr-MD237 TfIIA-SGD4733 photoreceptor cell TfIIA-SE73 photoreceptor cell R1 TfIIA-SE73 photoreceptor cell R6 TfIIA-SE73 photoreceptor cell R7 TfIIA-SE73 trichogen cell, with Scer\GAL4pnr-MD237 TfIIA-SGD4733
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of TfIIA-S Class Mutagen Stocks Known lesion TfIIA-SE73 hypomorphic allele - genetic evidence Delta2-3 1 Yes TfIIA-SGS97 Delta2-3 1 Yes TfIIA-SE31 amorphic allele - genetic evidence Delta2-3 0 Yes TfIIA-SE32 amorphic allele - genetic evidence Delta2-3 0 Yes TfIIA-SE62 amorphic allele - genetic evidence Delta2-3 0 Yes TfIIA-SE69 amorphic allele - genetic evidence Delta2-3 0 Yes TfIIA-SE89 amorphic allele - genetic evidence Delta2-3 0 Yes TfIIA-SEP3285 P-element activity 0 -- TfIIA-SS038611 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of TfIIA-S Class Mutagen Stocks Known lesion TfIIA-SGD4733 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes TfIIA-SGL00359 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TfIIA-S+t4 in vitro construct - genomic fragment 0 Yes TfIIA-Shs.PZ in vitro construct - regulatory fusion 0 Yes TfIIA-SKK102708 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)06624 (Zeidler et al., 1996, Haghayeghi et al., 2010) Df(3R)Exel9014 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hsp70-dTFIIA-S} NA UAS construct P{GD4733} NA P{KK102708} NA P{TRiP.GL00359} NA characterization construct P{dTFIIA-S} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}TfIIA-SEP3285 NA P{EPgy2}EY02323 NA P{GSV1}TfIIA-SGS97 NA insertion of enhancer trap P{lacW}TfIIA-SS038611 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
contributes_to RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly inferred from physical interaction with TfIIA-L (Yokomori et al., 1994) TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly inferred from physical interaction with Tbp (Yokomori et al., 1994)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) positive regulation of transcription from RNA polymerase II promoter inferred from direct assay (Yokomori et al., 1994)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Yokomori et al., 1994, Bernstein et al., 1994) transcription factor TFIIA complex inferred from direct assay (Yokomori et al., 1994)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
regulation of transcription from RNA polymerase II promoter non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) transcription initiation from RNA polymerase II promoter inferred from sequence or structural similarity with human GTF2A2 AND inferred from sequence or structural similarity with Saccharomyces TOA2 (Aoyagi and Wassarman, 2000)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) transcription factor TFIIA complex inferred from sequence or structural similarity with human GTF2A2 AND inferred from sequence or structural similarity with Saccharomyces TOA2 (Aoyagi and Wassarman, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions TfIIA-S allele Gene References TfIIA-SE73 Ras85D (Zeidler et al., 1996) rl (Zeidler et al., 1996) sev (Zeidler et al., 1996) svp (Zeidler et al., 1996) unspecified L (Singh et al., 2005) tor (Zeidler et al., 1996)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67758 DroID - A comprehensive database of gene and protein interactions. • FBgn0013347 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42822
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6D7ZSF Dipteran inclusive ortholog search EOG612MFZ Insect inclusive ortholog search EOG6R4Z0M Arthropod inclusive ortholog search EOG6SJ3XP Metazoa inclusive ortholog search EOG689HH2
Orthologs in Drosophila Species (EOG6D7ZSF)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\TfIIA-S     Drosophila simulans   Dsim\GD18345 Y   Drosophila sechellia   Dsec\GM23533 Y   Drosophila erecta   Dere\GG12397 Y   Drosophila yakuba   Dyak\GE23914 Y   Drosophila ananassae   Dana\GF18732 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18701 Y   Drosophila persimilis   Dper\GL24263 Y   Drosophila willistoni   Dwil\GK11978 Y   Drosophila virilis   Dvir\GJ24638 Y   Drosophila mojavensis   Dmoj\GI23054 Y   Drosophila grimshawi   Dgri\GH10565 Y
Orthologs in non-Drosophila Dipterans (EOG612MFZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002154   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL002140   Anopheles gambiae Malaria mosquito  Agam\AGAP004370   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ007398
Orthologs in non-Dipteran Insects (EOG6R4Z0M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\TfIIA-S   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005985   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22158   Atta cephalotes Leafcutter ant  Acep\ACEP14843   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22328   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19966   Linepithema humile Argentine ant  Lhum\LH16138   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20010   Solenopsis invicta Red fire ant  Sinv\SINV15360   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007048   Bombyx mori Silkmoth  Bmor\BGIBMGA005169   Pediculus humanus Human body louse  Phum\PHUM492470   Tribolium castaneum Red flour beetle  Tcas\TC009112
Orthologs in non-Insect Arthropods (EOG6SJ3XP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_230366   Ixodes scapularis Deer tick  Isca\ISCW010050
Orthologs in non-Arthropod Metazoa (EOG689HH2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\B0336.13 Y Caenorhabditis elegans Nematode  Cele\Y111B2A.13 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017723gn Y Danio rerio Zebrafish  Drer\zgc:110584 Y Xenopus tropicalis Western clawed frog  Xtro\gtf2a2 Y Xenopus tropicalis Western clawed frog  Xtro\gtf2a2 Y Gallus gallus Domestic chicken  Ggal\GTF2A2 Y Mus musculus House mouse  Mmus\Gtf2a2 Y Rattus norvegicus Norway rat  Rnor\Gtf2a2 Y Homo sapiens Human  Hsap\GTF2A2 Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\GTF2A2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD18345 Drosophila sechellia Dsec\GM23533 Drosophila erecta Dere\GG12397 Drosophila yakuba Dyak\GE23914 Drosophila ananassae Dana\GF18732 Drosophila pseudoobscura pseudoobscura Dpse\GA18701 Drosophila persimilis Dper\GL24263 Drosophila willistoni Dwil\GK11978 Drosophila virilis Dvir\GJ24638 Drosophila mojavensis Dmoj\GI23054 Drosophila grimshawi Dgri\GH10565
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	35800 y1 sc* v1; P{TRiP.GL00359}attP2 5436 w*; P{neoFRT}82B TfIIA-SE73/TM6B, Tb1
Kyoto	200041 y1 w67c23; P{GSV1}TfIIA-SGS97/TM3, Sb1 Ser1
VDRC	v12745 w1118; P{GD4733}v12745 v12746 w1118; P{GD4733}v12746/CyO
Genomic Clones ( 1 )
	BACR05C11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 107 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE44302
Other clones	FI01012
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03194 GM03032 LD31265 RH56668
Other clones	12070 31591 61574 120182 Dmel_dig_013742_0660_3359 EK112950 EK187238 EK251724 EN15207 FGC026A07 FGC027F07 FGH110G07 FGH115A05 FGH120B10 FGH122C01 FGH122F08 FGH123A03 FGH124A09 FGH124H06 FGH128H06 FGM206F09 FGM207C05 FGM212D02 FGM217D04 FGM218E05 FGM225F12 FGM225G05 FGM226G02 FGM231F06 FGM234B01 FGM301F08 FGM305B03 FGM309D11 FGM313F10 FGM318D11 FGM320D02 FGM320H09 FGM321G07 FGX001C11 RP003018300 RP003018411 RP003025575 RP003035702 RP003046397 RP003052887 RP003075137 RP003081125 RP003099863 RP003112800 RP003118135 RP003136841 RP003146929 RP003154363 RP003162583 RP003170017 RP003206581 RP003257025 RP003266642 RP003271952 RP003277824 RP003279289 RP003280689 RP003298125 RP003302654 RP003304149 RP003307410 RP003309117 RP003315715 RP003322565 RP003322661 RP003335434 RP003349358 RP003428692 RP003446326 RP003448434 RP003451726 RP003462070 RP003464888 RP003485691 RP003499105 RP003499742 RP003513405 RP003521973 RP003527072 RP003536017 RP003541840 RP003542128 RP003560555 RP003561860 RP003568040 RP003568199 RP003570393 RP003576712 RP003602495 RP003603690 RP003608994 RP003615514 RP003619821 RP003663129 RP003670184 RP003678754
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0013347 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42822
Antibody Information
	polyclonal (Bernstein et al., 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: TfIIA-S CG5163 (Kodira, 1999.11)
Source for database merge of	Source for merge of: TfIIA-S BcDNA:RE44302 (FlyBase, 1996-)
Additional comments	Source for merge of TfIIA-S BcDNA:RE44302 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	Expression is enriched in embryonic gonads. (Shigenobu et al., 2006) TfIIA-S is up-regulated and required during Ras-mediated photoreceptor determination. (Zeidler et al., 1996) 12.5kD small subunit of TFIIA is cloned and the properties of the recombinant protein are studied in vitro. The recombinant protein, in conjunction with human TFIIA, can support both promoter complex formation and transcriptional activated expression of TFIIA. (Bernstein et al., 1994) TfIIA-S has been isolated, molecularly cloned and expressed. Recombinant purified TfIIA-L and TfIIA-S can form a stable complex with Tbp on DNA, the recombinant protein can stimulate basal transcription and enhances transcriptional activation. (Yokomori et al., 1994) Mitotic recombination reveals TfIIA-S does not have a role in eye development. (Zeidler and Mlodzik, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079743 RefSeq (Proteins) • NP_524467 DDBJ / EMBL / GenBank • AAF56199 AAM29483 AY113478 BI357748 CAA58244 X83271 Entrez Gene - A searchable database of RefSeq genes. • 42822 UniProtKB/Swiss-Prot • P52656
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Transcription initiation factor IIA, gamma subunit, C-terminal (IPR015871) Transcription initiation factor IIA, gamma subunit, N-terminal (IPR015872) Transcription initiation factor IIA, gamma subunit (IPR003194) Transcription factor IIA, helical (IPR009083) Transcription factor IIA, beta-barrel (IPR009088) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • FI01012 RE44302
Linkouts
	BioGRID - A database of protein and genetic interactions • 67758 DroID - A comprehensive database of gene and protein interactions. • FBgn0013347 DRSC - Results from RNAi screens. • FBgn0013347 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013347 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5163-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0013347 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42822 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42822 modMine - Data generated by the modENCODE project. • FBgn0013347
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	BcDNA:RE44302   CG5163 (Aoyagi and Wassarman, 2000, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) dTFIIA (Ryu et al., 1999) dTFIIA-S (Miller et al., 2000, Zeidler, 1994.12.6, Vivas et al., 1999, Zeidler and Mlodzik, 1997, Zeidler et al., 1996, Bernstein et al., 1994, Yokomori et al., 1994) F121 (Zeidler and Mlodzik, 1993, ) TFIIA (Arnosti, 2002, Gu et al., 2002, Mizuguchi et al., 2001, Farkas et al., 2000, Pham et al., 1999, Rabenstein et al., 1999, Schock et al., 1999, Sandaltzopoulos and Becker, 1998, Hansen et al., 1997, Sauer et al., 1995, Sauer et al., 1995, Goodrich and Tjian, 1994) TFIIA-S (Maixner et al., 1998, Shigenobu et al., 2006, Hsu et al., 2008, Santoso and Kadonaga, 2006) TfIIA-S (Shigenobu et al., 2006) tfiia-s (Wood et al., 2008) TF-IIAS (Haghayeghi et al., 2010)
Name Synonym	Transcription-factor-IIA-S
Secondary FlyBase IDs
	FBgn0010326 FBgn0010327 FBgn0063013
References ( 57 )
Generate a list of	All references relating to this gene ( 57 )
List References by type	Research paper  ( 28 ) Supplementary material  ( 5 ) Review  ( 4 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 5 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 1 )
	Baradaran-Heravi et al., 2012, Hum. Mol. Genet. 21(11): 2572--2587 Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. [FBrf0218299] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...