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Gene Dmel\TpnC41C

General Information
Symbol	Dmel\TpnC41C	Species	D. melanogaster
Name	Troponin C at 41C	Annotation symbol	CG2981
Feature type	protein_coding_gene	FlyBase ID	FBgn0013348
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	TnC, DmTpnCIIIa, TnC41C
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	41D1-41D1	Sequence location	2R:952,742..957,715 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Troponin C at 41C is referred to in FlyBase by the symbol Dmel\TpnC41C (CG2981, FBgn0013348). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: calcium ion binding. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Calcium-binding EF-hand; EF-HAND 2; EF-Hand 1, calcium-binding site; EF-hand; EF-hand-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head. Comments on Affy2 ProbeSet: ProbeSet 1625752_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of TpnC41C. Gene sequence location is 2R:952742..957715.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA04916 BKN32771 References Rui et al., 2010, PLoS Genet. 6(11): e1001208
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 41D1-41D1   Limits computationally determined from genome sequence between P{PZ}vlc07022&P{lacW}l(2)09851k08138 and P{PZ}l(2)0985109851&P{lacW}Src42Ak10108
Experimentally Determined Cytological Location
Cytogenetic map Notes References 41C-41C   (determined by in situ hybridisation)   (Fyrberg et al., 1994)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\TpnC41C for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) TpnC41C-RA FBtr0086102  NM_078895   826   154 TpnC41C-RB FBtr0310003     1880   154
Additional Transcript Data & Comments
Reported size (kB)	0.9 (northern blot) (Fyrberg et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein TpnC41C-PA   FBpp0085438   17.2   154   3.60     NP_523619   AAF57350 TpnC41C-PB   FBpp0301709   17.2   154   3.60
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • EF-Hand 1, calcium-binding site (IPR018247) EF-HAND 2 (IPR018249) Calcium-binding EF-hand (IPR002048) EF-hand-like domain (IPR011992) EF-hand (IPR018248)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57350   AY075534 AAL68341   BI572004   BI572344   BI591412   CO186976   CO278405   CO293863   CO295306   CO313272   CO314478   CO332344   CO334103   CS025546   EC064193   EC064905   EC065188   EC090850   EC205268   EC224375   X76043 CAA53628
UniProtKB/Swiss-Prot	P47947
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference pupal stage | mid     (Fyrberg et al., 1994) pupal stage | late     (Fyrberg et al., 1994) adult stage     (Fyrberg et al., 1994) pcr Stage Tissue/Position (including subcellular localization) Reference pupal stage -- adult stage   organism   (Qiu et al., 2003)
Additional Descriptive Data
	TpnC41C transcripts are detected in mid-late pupae and adults. (Fyrberg et al., 1994)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage   leg   (Qiu et al., 2003) indirect flight muscle   (Qiu et al., 2003)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0013348    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0013348 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of extremely low expression. Peak expression observed during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0013348 expression level Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    9 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    20 embryo 10-12hr    35 embryo 12-14hr    78 embryo 14-16hr    84 embryo 16-18hr    405 embryo 18-20hr    318 embryo 20-22hr    169 embryo 22-24hr    314 larva L1    22 larva L2    16 larva L3 12hr old    25 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    15 white prepupae new    83 white prepupae 12hr    226 white prepupae 24hr    12 pupae 2d postWPP    4815 pupae 3d postWPP    29277 pupae 4d postWPP    24060 adult male 01day    24719 adult male 05day    6157 adult male 30day    1902 adult female 01day    8631 adult female 05day    1129 adult female 30day    523 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    9 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    20 embryo 10-12hr    35 embryo 12-14hr    78 embryo 14-16hr    84 embryo 16-18hr  (405) embryo 18-20hr  (318) embryo 20-22hr  (169) embryo 22-24hr  (314) larva L1    22 larva L2    16 larva L3 12hr old    25 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    15 white prepupae new    83 white prepupae 12hr  (226) white prepupae 24hr    12 pupae 2d postWPP  (4815) pupae 3d postWPP  (29277) pupae 4d postWPP  (24060) adult male 01day  (24719) adult male 05day  (6157) adult male 30day  (1902) adult female 01day  (8631) adult female 05day  (1129) adult female 30day  (523) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    9 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    20 embryo 10-12hr    35 embryo 12-14hr    78 embryo 14-16hr    84 embryo 16-18hr    405 embryo 18-20hr    318 embryo 20-22hr    169 embryo 22-24hr    314 larva L1    22 larva L2    16 larva L3 12hr old    25 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    15 white prepupae new    83 white prepupae 12hr    226 white prepupae 24hr    12 pupae 2d postWPP  (4815) pupae 3d postWPP  (29277) pupae 4d postWPP  (24060) adult male 01day  (24719) adult male 05day  (6157) adult male 30day  (1902) adult female 01day  (8631) adult female 05day    1129 adult female 30day    523 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    9 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    20 embryo 10-12hr    35 embryo 12-14hr    78 embryo 14-16hr    84 embryo 16-18hr    405 embryo 18-20hr    318 embryo 20-22hr    169 embryo 22-24hr    314 larva L1    22 larva L2    16 larva L3 12hr old    25 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    15 white prepupae new    83 white prepupae 12hr    226 white prepupae 24hr    12 pupae 2d postWPP    4815 pupae 3d postWPP  (29277) pupae 4d postWPP  (24060) adult male 01day  (24719) adult male 05day    6157 adult male 30day    1902 adult female 01day    8631 adult female 05day    1129 adult female 30day    523 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    9 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    20 embryo 10-12hr    35 embryo 12-14hr    78 embryo 14-16hr    84 embryo 16-18hr    405 embryo 18-20hr    318 embryo 20-22hr    169 embryo 22-24hr    314 larva L1    22 larva L2    16 larva L3 12hr old    25 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    15 white prepupae new    83 white prepupae 12hr    226 white prepupae 24hr    12 pupae 2d postWPP    4815 pupae 3d postWPP    29277 pupae 4d postWPP    24060 adult male 01day    24719 adult male 05day    6157 adult male 30day    1902 adult female 01day    8631 adult female 05day    1129 adult female 30day    523 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0013348 expression level Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    9 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    20 embryo 10-12hr    35 embryo 12-14hr    78 embryo 14-16hr    84 embryo 16-18hr    405 embryo 18-20hr    318 embryo 20-22hr    169 embryo 22-24hr    314 larva L1    22 larva L2    16 larva L3 12hr old    25 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    15 white prepupae new    83 white prepupae 12hr    226 white prepupae 24hr    12 pupae 2d postWPP    4815 pupae 3d postWPP    29277 pupae 4d postWPP    24060 adult male 01day    24719 adult male 05day    6157 adult male 30day    1902 adult female 01day    8631 adult female 05day    1129 adult female 30day    523 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    9 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    20 embryo 10-12hr    35 embryo 12-14hr    78 embryo 14-16hr    84 embryo 16-18hr  (405) embryo 18-20hr  (318) embryo 20-22hr  (169) embryo 22-24hr  (314) larva L1    22 larva L2    16 larva L3 12hr old    25 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    15 white prepupae new    83 white prepupae 12hr  (226) white prepupae 24hr    12 pupae 2d postWPP  (4815) pupae 3d postWPP  (29277) pupae 4d postWPP  (24060) adult male 01day  (24719) adult male 05day  (6157) adult male 30day  (1902) adult female 01day  (8631) adult female 05day  (1129) adult female 30day  (523) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    9 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    20 embryo 10-12hr    35 embryo 12-14hr    78 embryo 14-16hr    84 embryo 16-18hr    405 embryo 18-20hr    318 embryo 20-22hr    169 embryo 22-24hr    314 larva L1    22 larva L2    16 larva L3 12hr old    25 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    15 white prepupae new    83 white prepupae 12hr    226 white prepupae 24hr    12 pupae 2d postWPP  (4815) pupae 3d postWPP  (29277) pupae 4d postWPP  (24060) adult male 01day  (24719) adult male 05day  (6157) adult male 30day  1902 adult female 01day  (8631) adult female 05day    1129 adult female 30day    523 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    9 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    20 embryo 10-12hr    35 embryo 12-14hr    78 embryo 14-16hr    84 embryo 16-18hr    405 embryo 18-20hr    318 embryo 20-22hr    169 embryo 22-24hr    314 larva L1    22 larva L2    16 larva L3 12hr old    25 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    15 white prepupae new    83 white prepupae 12hr    226 white prepupae 24hr    12 pupae 2d postWPP    4815 pupae 3d postWPP  (29277) pupae 4d postWPP  (24060) adult male 01day  (24719) adult male 05day    6157 adult male 30day    1902 adult female 01day    8631 adult female 05day    1129 adult female 30day    523 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6 embryo 02-04hr    9 embryo 04-06hr    2 embryo 06-08hr    6 embryo 08-10hr    20 embryo 10-12hr    35 embryo 12-14hr    78 embryo 14-16hr    84 embryo 16-18hr    405 embryo 18-20hr    318 embryo 20-22hr    169 embryo 22-24hr    314 larva L1    22 larva L2    16 larva L3 12hr old    25 larva L3 puffstage 1-2    2 larva L3 puffstage 3-6    3 larva L3 puffstage 7-9    15 white prepupae new    83 white prepupae 12hr    226 white prepupae 24hr    12 pupae 2d postWPP    4815 pupae 3d postWPP    29277 pupae 4d postWPP    24060 adult male 01day    24719 adult male 05day    6157 adult male 30day    1902 adult female 01day    8631 adult female 05day    1129 adult female 30day    523 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0013348    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0013348 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0013348 expression level Tissue   Expression Level Larval Central Nervous System    2.925 Larval Midgut    4.6 Larval Hindgut    1.9 Larval Malpighian Tubules    2.6 Larval Fat Body    1.7 Larval Salivary Gland    0.7 Larval Trachea    3.15 Larval Carcass    6.35 Adult Head    340.5 Adult Eye    22.6 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop no informative data Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4 Adult Fat Body no informative data Adult Salivary Gland    8.2 Adult Heart    7.3 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    3.3 Adult Testis    3.1 Adult Male Accessory Gland    2.2 Adult Carcass    2047.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.925 Larval Midgut    4.6 Larval Hindgut    1.9 Larval Malpighian Tubules    2.6 Larval Fat Body    1.7 Larval Salivary Gland    0.7 Larval Trachea    3.15 Larval Carcass    6.35 Adult Head    340.5 Adult Eye    22.6 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop no informative data Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4 Adult Fat Body no informative data Adult Salivary Gland    8.2 Adult Heart    7.3 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    3.3 Adult Testis    3.1 Adult Male Accessory Gland    2.2 Adult Carcass  (2047.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.925 Larval Midgut    4.6 Larval Hindgut    1.9 Larval Malpighian Tubules    2.6 Larval Fat Body    1.7 Larval Salivary Gland    0.7 Larval Trachea    3.15 Larval Carcass    6.35 Adult Head    340.5 Adult Eye    22.6 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop no informative data Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4 Adult Fat Body no informative data Adult Salivary Gland    8.2 Adult Heart    7.3 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    3.3 Adult Testis    3.1 Adult Male Accessory Gland    2.2 Adult Carcass  (2047.3) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.925 Larval Midgut    4.6 Larval Hindgut    1.9 Larval Malpighian Tubules    2.6 Larval Fat Body    1.7 Larval Salivary Gland    0.7 Larval Trachea    3.15 Larval Carcass    6.35 Adult Head    340.5 Adult Eye    22.6 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop no informative data Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4 Adult Fat Body no informative data Adult Salivary Gland    8.2 Adult Heart    7.3 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    3.3 Adult Testis    3.1 Adult Male Accessory Gland    2.2 Adult Carcass    2047.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0013348 expression level Tissue   Expression Level Larval Central Nervous System    2.925 Larval Midgut    4.6 Larval Hindgut    1.9 Larval Malpighian Tubules    2.6 Larval Fat Body    1.7 Larval Salivary Gland    0.7 Larval Trachea    3.15 Larval Carcass    6.35 Adult Head    340.5 Adult Eye    22.6 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop no informative data Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4 Adult Fat Body no informative data Adult Salivary Gland    8.2 Adult Heart    7.3 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    3.3 Adult Testis    3.1 Adult Male Accessory Gland    2.2 Adult Carcass    2047.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.925 Larval Midgut    4.6 Larval Hindgut    1.9 Larval Malpighian Tubules    2.6 Larval Fat Body    1.7 Larval Salivary Gland    0.7 Larval Trachea    3.15 Larval Carcass    6.35 Adult Head    340.5 Adult Eye    22.6 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop no informative data Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4 Adult Fat Body no informative data Adult Salivary Gland    8.2 Adult Heart    7.3 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    3.3 Adult Testis    3.1 Adult Male Accessory Gland    2.2 Adult Carcass  (2047.3) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.925 Larval Midgut    4.6 Larval Hindgut    1.9 Larval Malpighian Tubules    2.6 Larval Fat Body    1.7 Larval Salivary Gland    0.7 Larval Trachea    3.15 Larval Carcass    6.35 Adult Head    340.5 Adult Eye    22.6 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop no informative data Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4 Adult Fat Body no informative data Adult Salivary Gland    8.2 Adult Heart    7.3 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    3.3 Adult Testis    3.1 Adult Male Accessory Gland    2.2 Adult Carcass  (2047.3) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.925 Larval Midgut    4.6 Larval Hindgut    1.9 Larval Malpighian Tubules    2.6 Larval Fat Body    1.7 Larval Salivary Gland    0.7 Larval Trachea    3.15 Larval Carcass    6.35 Adult Head    340.5 Adult Eye    22.6 Adult Brain    3.3 Adult Thoracic-Abdominal Ganglion    59.7 Adult Crop no informative data Adult Midgut    4.7 Adult Hindgut no informative data Adult Malpighian Tubules    4 Adult Fat Body no informative data Adult Salivary Gland    8.2 Adult Heart    7.3 Adult VirginFemale Spermatheca    2.1 Adult InseminatedFemale Spermatheca    1.5 Adult Ovary    3.3 Adult Testis    3.1 Adult Male Accessory Gland    2.2 Adult Carcass    2047.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut     Adult Hindgut no informative data Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    340.5   NA  Eye    22.6   NA  Brain    3.3   2.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    59.7   NA  Crop    no informative data   4.6  Midgut    4.7   1.9  Hindgut    no informative data   2.6  Malpighian Tubules    4   1.7  Fat Body    no informative data   0.7  Salivary Gland    8.2   NA  Heart    7.3   3.15  Trachea    NA   NA  VirginFemale Spermatheca    2.1   NA  InseminatedFemale Spermatheca    1.5   NA  Ovary    3.3   NA  Testis    3.1   NA  Male Accessory Gland    2.2   6.35  Carcass    2047.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_00
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013348 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2981-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of TpnC41C Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of TpnC41C Class Mutagen Stocks Known lesion TpnC41CJF02379 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TpnC41CKK112771 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes TpnC41CGD9873 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes TpnC41CNIG.2981R in vitro construct - RNAi in vitro construct - regulatory fusion 0 --
Aneuploid Aberrations
Disrupted in	Df(2R)M41A8 (Myster et al., 2004) Df(2R)M41A10 (Myster et al., 2004) Df(2R)Nipped-D (Myster et al., 2004)
Not disrupted in	Df(2R)M41A2 (Myster et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9873} NA P{KK112771} NA P{TRiP.JF02379} NA characterization construct P{NIG.2981R} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
calcium ion binding inferred from sequence or structural similarity with UniProtKB:P15159 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1996.2.1)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions TpnC41C allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61394 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0013348 DroID - A comprehensive database of gene and protein interactions. • FBgn0013348 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35473
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13927 Dere\GG10878 Dgri\GH21731 Dmoj\GI18874 Dper\GL11049 Dsec\GM13554 Dsim\GD16679 Dvir\TpnCIIIa Dwil\GK21371 Dyak\GE11315
Curated drosophilid orthologs	Dpse\GA15555   Dpse\TpnCIIIa (Herranz et al., 2005) Dsub\TpnCIIIa (Herranz et al., 2005) Dvir\TpnCIIIa (Herranz et al., 2005) Dvir\TpnCIIIb
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006572-PC Aedes aegypti (mosquito) AGAP006179-PA Anopheles gambiae (mosquito) NP_001011651.1 Apis mellifera (honey bee) XP_001943128.1 Acyrthosiphon pisum (pea aphid) BGIBMGA006742-PA Bombyx mori (silk worm) CPIJ012250 Culex pipens (mosquito) CPIJ016821 Culex pipens (mosquito) 256636 Daphnia pulex (daphnia) XP_970615.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14556 NV51218 LH13999 FBgn0229130 FBgn0223363 FBgn0067464 FBgn0188268 FBgn0168485 JGI_V11_256636 FBgn0148659 FBgn0141613 FBgn0129192 FBgn0103182 FBgn0090954 CPIJ012250 CPIJ016821 BGIBMGA006742 BGIBMGA006743 ACYPI007392 GB13594 AGAP006179 AAEL006572 GLEAN_12196
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	27053 y1 v1; P{TRiP.JF02379}attP2
VDRC	v104894 P{KK112771}VIE-260B
Genomic Clones ( 1 )
	BACR21G13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 18 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH07835
Other clones	DPiM_RH07835
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH05182 RH07339
Other clones	75082 79468 102798 106393 275397 283598 EK025108 EK130005 EK205013 EK209361 EK232046 EK236624 EK303219 EK308910
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0013348 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35473
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: TpnC41C CG2981 (Lai, 1999.11)
Source for database merge of
Additional comments
Other Comments
	Isolation and characterisation of Troponin C like gene TpnC41C. (Fyrberg et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078895 RefSeq (Proteins) • NP_523619 DDBJ / EMBL / GenBank • AAF57350 AAF57350.1 AAL68341 AY075534 BI572344 CAA53628 CS025546 X76043 Entrez Gene - A searchable database of RefSeq genes. • 35473 UniProtKB/Swiss-Prot • P47947
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • EF-Hand 1, calcium-binding site (IPR018247) EF-HAND 2 (IPR018249) Calcium-binding EF-hand (IPR002048) EF-hand-like domain (IPR011992) EF-hand (IPR018248)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61394 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0013348 DroID - A comprehensive database of gene and protein interactions. • FBgn0013348 DRSC - Results from RNAi screens. • FBgn0013348 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013348 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2981-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0013348 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35473 InParanoid A subset of ortholog calls from InParanoid. • AAEL006572-PC Aedes aegypti (mosquito) AGAP006179-PA Anopheles gambiae (mosquito) NP_001011651.1 Apis mellifera (honey bee) XP_001943128.1 Acyrthosiphon pisum (pea aphid) BGIBMGA006742-PA Bombyx mori (silk worm) CPIJ012250 Culex pipens (mosquito) CPIJ016821 Culex pipens (mosquito) 256636 Daphnia pulex (daphnia) XP_970615.1 Tribolium castaneum (red flour beetle) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35473 modMine - Data generated by the modENCODE project. • FBgn0013348 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14556 NV51218 LH13999 FBgn0229130 FBgn0223363 FBgn0067464 FBgn0188268 FBgn0168485 JGI_V11_256636 FBgn0148659 FBgn0141613 FBgn0129192 FBgn0103182 FBgn0090954 CPIJ012250 CPIJ016821 BGIBMGA006742 BGIBMGA006743 ACYPI007392 GB13594 AGAP006179 AAEL006572 GLEAN_12196
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG2981 (Dimitri et al., 2005, Goldstein and Gunawardena, 2000, Goldman and Arbeitman, 2007, Perkins et al., 2009.3.31, Keleman et al., 2009.8.5, Coulthard et al., 2010, Cammarato et al., 2011) DmTnC1 (Qiu et al., 2003) DmTpnC41C (Herranz et al., 2004) DmTpnCIIIa (Herranz et al., 2004, Herranz et al., 2005) TnC (Nongthomba et al., 2004, Ruiz et al., 2002, Vikhorev et al., 2010, Rui et al., 2010) TnC1 (Vikhorev et al., 2010) TnC41C (Fyrberg, 1993.11.8, ) TNC41C (Diaz-Castillo and Golic, 2007) TPNC (Goldstein and Gunawardena, 2000) TpnC41C (Rossi et al., 2007, Montana and Littleton, 2006, McGraw et al., 2008, Dierick and Greenspan, 2006, Carpenter et al., 2009, Betz and Darnell, 2006) TpnC IIIa (Herranz et al., 2004) TpnCIIIa (Herranz et al., 2005) unnamed (Vigoreaux, 2001)
Name Synonym	troponin C (Vikhorev et al., 2010) Troponin C at 41C (Goldman and Arbeitman, 2007, Harbison et al., 2005, Cammarato et al., 2011) TroponinC at 41C (McGraw et al., 2008)
Secondary FlyBase IDs
	FBan0041446 FBgn0084010
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 24 ) Supplementary material  ( 5 ) Review  ( 4 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 3 )
	Coulthard et al., 2010, Genetics 185(2): 479--495 Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. [FBrf0211235] Rui et al., 2010, PLoS Genet. 6(11): e1001208 Sarcomere formation occurs by the assembly of multiple latent protein complexes. [FBrf0212444] Vikhorev et al., 2010, J. Muscle Res. Cell Motility 31(3): 171--179 In vitro motility of native thin filaments from Drosophila indirect flight muscles reveals that the held-up 2 TnI mutation affects calcium activation. [FBrf0211686] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...