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Gene Dmel\cdc2rk

General Information
Symbol	Dmel\cdc2rk	Species	D. melanogaster
Name	cdc2-related-kinase	Annotation symbol	CG1362
Feature type	protein_coding_gene	FlyBase ID	FBgn0013435
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	Dcdrk
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	46E1-46E1	Sequence location	2R:5,954,722..5,956,206 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene cdc2-related-kinase is referred to in FlyBase by the symbol Dmel\cdc2rk (CG1362, FBgn0013435). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cyclin-dependent protein kinase activity. Based on sequence similarity, it is predicted to be involved in the biological process: protein phosphorylation. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1624400_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of cdc2rk. Gene sequence location is 2R:5954722..5956206.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN50074 BKN27629 HFA07590
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 46E1-46E1   Limits computationally determined from genome sequence between P{lacW}Adamk13906&P{EP}Pka-R2EP2162 and P{PZ}14-3-3ζ07103
Experimentally Determined Cytological Location
Cytogenetic map Notes References 46E1-46E9   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cdc2rk for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cdc2rk-RA FBtr0088429  NM_078950   1250   387
Additional Transcript Data & Comments
Reported size (kB)	1.8 (unknown) (Sugaya et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cdc2rk-PA   FBpp0087515   43.4   387   7.95     NP_523674   AAF58851
Additional Polypeptide Data & Comments
Reported size (kDa)	349 (aa) (Sugaya et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF58851   AC005974   BF494190   BI240810   BT001627 AAN71382   BT088969   BT089018   BT099569   CO284060   CO300309   CO314868   CO324766   D16402 BAA03886   EC055432   EC210359   EC214282   EC234382   GH754203   GH758819   GH780734   GH781467   GH785388   GH785397   GH788487   GH791359   GH795436   GH797815   GH805209   GH805639   GH810159   GH811374   GH817729   GH820636   GH833330   GH837465   GH848663   GH848728   GH851852   GH858508   GH861094   GH861163   GH863451   GH872618   GH872995   GH873556   GH876357   GH878284   GH879731   GH881212   GH901509   GH905364   GH912196   GH919029   GH921186   GH922552   GH927260   GH929069   GH932474   GH935670   GH936697   GH937887   GH960164   GH972776
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q24294 Q8IGS3 A1Z841 A1Z840
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Sugaya et al., 1994) embryonic stage -- adult stage     (Sugaya et al., 1994)
Additional Descriptive Data
	cdc2rk transcripts are detected at nearly constant levels throughout the life cycle on northern blots. In situ hybridization in embryos reveals that transcripts are nearly uniformly distributed in all regions. Elevated levels are observed in the invaginated midgut. (Sugaya et al., 1994)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0013435    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0013435 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0013435 expression level Developmental Stage   Expression Level embryo 00-02hr    729 embryo 02-04hr    782 embryo 04-06hr    698 embryo 06-08hr    1064 embryo 08-10hr    1235 embryo 10-12hr    1207 embryo 12-14hr    958 embryo 14-16hr    375 embryo 16-18hr    355 embryo 18-20hr    291 embryo 20-22hr    310 embryo 22-24hr    323 larva L1    465 larva L2    457 larva L3 12hr old    299 larva L3 puffstage 1-2    476 larva L3 puffstage 3-6    474 larva L3 puffstage 7-9    591 white prepupae new    709 white prepupae 12hr    633 white prepupae 24hr    731 pupae 2d postWPP    498 pupae 3d postWPP    368 pupae 4d postWPP    226 adult male 01day    310 adult male 05day    358 adult male 30day    353 adult female 01day    478 adult female 05day    835 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (729) embryo 02-04hr  (782) embryo 04-06hr  (698) embryo 06-08hr  (1064) embryo 08-10hr  (1235) embryo 10-12hr  (1207) embryo 12-14hr  (958) embryo 14-16hr  (375) embryo 16-18hr  (355) embryo 18-20hr  (291) embryo 20-22hr  (310) embryo 22-24hr  (323) larva L1  (465) larva L2  (457) larva L3 12hr old  (299) larva L3 puffstage 1-2  (476) larva L3 puffstage 3-6  (474) larva L3 puffstage 7-9  (591) white prepupae new  (709) white prepupae 12hr  (633) white prepupae 24hr  (731) pupae 2d postWPP  (498) pupae 3d postWPP  (368) pupae 4d postWPP  (226) adult male 01day  (310) adult male 05day  (358) adult male 30day  (353) adult female 01day  (478) adult female 05day  (835) adult female 30day  (828) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    729 embryo 02-04hr    782 embryo 04-06hr    698 embryo 06-08hr    1064 embryo 08-10hr    1235 embryo 10-12hr    1207 embryo 12-14hr    958 embryo 14-16hr    375 embryo 16-18hr    355 embryo 18-20hr    291 embryo 20-22hr    310 embryo 22-24hr    323 larva L1    465 larva L2    457 larva L3 12hr old    299 larva L3 puffstage 1-2    476 larva L3 puffstage 3-6    474 larva L3 puffstage 7-9    591 white prepupae new    709 white prepupae 12hr    633 white prepupae 24hr    731 pupae 2d postWPP    498 pupae 3d postWPP    368 pupae 4d postWPP    226 adult male 01day    310 adult male 05day    358 adult male 30day    353 adult female 01day    478 adult female 05day    835 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    729 embryo 02-04hr    782 embryo 04-06hr    698 embryo 06-08hr    1064 embryo 08-10hr    1235 embryo 10-12hr    1207 embryo 12-14hr    958 embryo 14-16hr    375 embryo 16-18hr    355 embryo 18-20hr    291 embryo 20-22hr    310 embryo 22-24hr    323 larva L1    465 larva L2    457 larva L3 12hr old    299 larva L3 puffstage 1-2    476 larva L3 puffstage 3-6    474 larva L3 puffstage 7-9    591 white prepupae new    709 white prepupae 12hr    633 white prepupae 24hr    731 pupae 2d postWPP    498 pupae 3d postWPP    368 pupae 4d postWPP    226 adult male 01day    310 adult male 05day    358 adult male 30day    353 adult female 01day    478 adult female 05day    835 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    729 embryo 02-04hr    782 embryo 04-06hr    698 embryo 06-08hr    1064 embryo 08-10hr    1235 embryo 10-12hr    1207 embryo 12-14hr    958 embryo 14-16hr    375 embryo 16-18hr    355 embryo 18-20hr    291 embryo 20-22hr    310 embryo 22-24hr    323 larva L1    465 larva L2    457 larva L3 12hr old    299 larva L3 puffstage 1-2    476 larva L3 puffstage 3-6    474 larva L3 puffstage 7-9    591 white prepupae new    709 white prepupae 12hr    633 white prepupae 24hr    731 pupae 2d postWPP    498 pupae 3d postWPP    368 pupae 4d postWPP    226 adult male 01day    310 adult male 05day    358 adult male 30day    353 adult female 01day    478 adult female 05day    835 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0013435 expression level Developmental Stage   Expression Level embryo 00-02hr    729 embryo 02-04hr    782 embryo 04-06hr    698 embryo 06-08hr    1064 embryo 08-10hr    1235 embryo 10-12hr    1207 embryo 12-14hr    958 embryo 14-16hr    375 embryo 16-18hr    355 embryo 18-20hr    291 embryo 20-22hr    310 embryo 22-24hr    323 larva L1    465 larva L2    457 larva L3 12hr old    299 larva L3 puffstage 1-2    476 larva L3 puffstage 3-6    474 larva L3 puffstage 7-9    591 white prepupae new    709 white prepupae 12hr    633 white prepupae 24hr    731 pupae 2d postWPP    498 pupae 3d postWPP    368 pupae 4d postWPP    226 adult male 01day    310 adult male 05day    358 adult male 30day    353 adult female 01day    478 adult female 05day    835 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (729) embryo 02-04hr  (782) embryo 04-06hr  (698) embryo 06-08hr  (1064) embryo 08-10hr  (1235) embryo 10-12hr  (1207) embryo 12-14hr  (958) embryo 14-16hr  (375) embryo 16-18hr  (355) embryo 18-20hr  (291) embryo 20-22hr  (310) embryo 22-24hr  (323) larva L1  (465) larva L2  (457) larva L3 12hr old  (299) larva L3 puffstage 1-2  (476) larva L3 puffstage 3-6  (474) larva L3 puffstage 7-9  (591) white prepupae new  (709) white prepupae 12hr  (633) white prepupae 24hr  (731) pupae 2d postWPP  (498) pupae 3d postWPP  (368) pupae 4d postWPP  (226) adult male 01day  (310) adult male 05day  (358) adult male 30day  (353) adult female 01day  (478) adult female 05day  (835) adult female 30day  (828) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    729 embryo 02-04hr    782 embryo 04-06hr    698 embryo 06-08hr    1064 embryo 08-10hr    1235 embryo 10-12hr    1207 embryo 12-14hr    958 embryo 14-16hr    375 embryo 16-18hr    355 embryo 18-20hr    291 embryo 20-22hr    310 embryo 22-24hr    323 larva L1    465 larva L2    457 larva L3 12hr old    299 larva L3 puffstage 1-2    476 larva L3 puffstage 3-6    474 larva L3 puffstage 7-9    591 white prepupae new    709 white prepupae 12hr    633 white prepupae 24hr    731 pupae 2d postWPP    498 pupae 3d postWPP    368 pupae 4d postWPP    226 adult male 01day    310 adult male 05day    358 adult male 30day    353 adult female 01day    478 adult female 05day    835 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    729 embryo 02-04hr    782 embryo 04-06hr    698 embryo 06-08hr    1064 embryo 08-10hr    1235 embryo 10-12hr    1207 embryo 12-14hr    958 embryo 14-16hr    375 embryo 16-18hr    355 embryo 18-20hr    291 embryo 20-22hr    310 embryo 22-24hr    323 larva L1    465 larva L2    457 larva L3 12hr old    299 larva L3 puffstage 1-2    476 larva L3 puffstage 3-6    474 larva L3 puffstage 7-9    591 white prepupae new    709 white prepupae 12hr    633 white prepupae 24hr    731 pupae 2d postWPP    498 pupae 3d postWPP    368 pupae 4d postWPP    226 adult male 01day    310 adult male 05day    358 adult male 30day    353 adult female 01day    478 adult female 05day    835 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    729 embryo 02-04hr    782 embryo 04-06hr    698 embryo 06-08hr    1064 embryo 08-10hr    1235 embryo 10-12hr    1207 embryo 12-14hr    958 embryo 14-16hr    375 embryo 16-18hr    355 embryo 18-20hr    291 embryo 20-22hr    310 embryo 22-24hr    323 larva L1    465 larva L2    457 larva L3 12hr old    299 larva L3 puffstage 1-2    476 larva L3 puffstage 3-6    474 larva L3 puffstage 7-9    591 white prepupae new    709 white prepupae 12hr    633 white prepupae 24hr    731 pupae 2d postWPP    498 pupae 3d postWPP    368 pupae 4d postWPP    226 adult male 01day    310 adult male 05day    358 adult male 30day    353 adult female 01day    478 adult female 05day    835 adult female 30day    828 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0013435    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0013435 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0013435 expression level Tissue   Expression Level Larval Central Nervous System    75.325 Larval Midgut no informative data Larval Hindgut    31.1 Larval Malpighian Tubules    24.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    40.075 Larval Carcass no informative data Adult Head no informative data Adult Eye    54.8 Adult Brain    48.5 Adult Thoracic-Abdominal Ganglion    40.4 Adult Crop    33.1 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    41.5 Adult Testis    22 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    75.325 Larval Midgut no informative data Larval Hindgut    31.1 Larval Malpighian Tubules    24.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    40.075 Larval Carcass no informative data Adult Head no informative data Adult Eye    54.8 Adult Brain    48.5 Adult Thoracic-Abdominal Ganglion    40.4 Adult Crop    33.1 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    41.5 Adult Testis    22 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    75.325 Larval Midgut no informative data Larval Hindgut    31.1 Larval Malpighian Tubules    24.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    40.075 Larval Carcass no informative data Adult Head no informative data Adult Eye    54.8 Adult Brain    48.5 Adult Thoracic-Abdominal Ganglion    40.4 Adult Crop    33.1 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    41.5 Adult Testis    22 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    75.325 Larval Midgut no informative data Larval Hindgut    31.1 Larval Malpighian Tubules    24.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    40.075 Larval Carcass no informative data Adult Head no informative data Adult Eye    54.8 Adult Brain    48.5 Adult Thoracic-Abdominal Ganglion    40.4 Adult Crop    33.1 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    41.5 Adult Testis    22 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0013435 expression level Tissue   Expression Level Larval Central Nervous System    75.325 Larval Midgut no informative data Larval Hindgut    31.1 Larval Malpighian Tubules    24.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    40.075 Larval Carcass no informative data Adult Head no informative data Adult Eye    54.8 Adult Brain    48.5 Adult Thoracic-Abdominal Ganglion    40.4 Adult Crop    33.1 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    41.5 Adult Testis    22 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    75.325 Larval Midgut no informative data Larval Hindgut    31.1 Larval Malpighian Tubules    24.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    40.075 Larval Carcass no informative data Adult Head no informative data Adult Eye    54.8 Adult Brain    48.5 Adult Thoracic-Abdominal Ganglion    40.4 Adult Crop    33.1 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    41.5 Adult Testis    22 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    75.325 Larval Midgut no informative data Larval Hindgut    31.1 Larval Malpighian Tubules    24.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    40.075 Larval Carcass no informative data Adult Head no informative data Adult Eye    54.8 Adult Brain    48.5 Adult Thoracic-Abdominal Ganglion    40.4 Adult Crop    33.1 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    41.5 Adult Testis    22 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    75.325 Larval Midgut no informative data Larval Hindgut    31.1 Larval Malpighian Tubules    24.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    40.075 Larval Carcass no informative data Adult Head no informative data Adult Eye    54.8 Adult Brain    48.5 Adult Thoracic-Abdominal Ganglion    40.4 Adult Crop    33.1 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    26.8 Adult Ovary    41.5 Adult Testis    22 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    54.8   NA  Brain    48.5   75.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    40.4   NA  Crop    33.1   no informative data  Midgut    no informative data   31.1  Hindgut    no informative data   24.4  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    no informative data   40.075  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    26.8   NA  Ovary    41.5   NA  Testis    22   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013435 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1362-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 cdc2rkGD8076 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of cdc2rk Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cdc2rk Class Mutagen Stocks Known lesion cdc2rkGD8076 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cdc2rkGL00232 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cdc2rkKK107629 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8076} NA P{KK107629} NA P{TRiP.GL00232} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) cyclin-dependent protein kinase activity inferred from sequence or structural similarity (Sugaya et al., 1994) protein serine/threonine kinase activity inferred from electronic annotation with InterPro:IPR008271 (FlyBase Curators et al., 2004-) non-traceable author statement (Emori, 1993.6.7, Morrison et al., 2000)
Biological Process
CV term Evidence References
nuclear mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Sugaya et al., 1994) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cdc2rk allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0013435 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36051
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12911 Dere\GG25234 Dgri\GH19966 Dmoj\GI20253 Dper\GL10557 Dpse\GA12412 Dsec\GM20555 Dsim\GD26008 Dvir\GJ20206 Dwil\GK21358 Dyak\GE21808
Curated drosophilid orthologs	Dpse\GA12412
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005191-PA Aedes aegypti (mosquito) AGAP005851-PA Anopheles gambiae (mosquito) XP_392973.3 Apis mellifera (honey bee) XP_001952546.1 Acyrthosiphon pisum (pea aphid) At5g63370.1 Arabidopsis thaliana (wall cress) 3387 Batrachochytrium dendrobatidis (chytrid fungus) 228782 Branchiostoma floridae (lancelet) XP_001893098.1 Brugia malayi (roundworm nematode) BGIBMGA006777-PA Bombyx mori (silk worm) ENSBTAP00000016228 Bos taurus (bovine) ENSBTAP00000044609 Bos taurus (bovine) ENSCAFP00000029349 Canis familiaris (dog) ENSCINP00000007891 Ciona intestinalis (sea squirt) CPIJ002062 Culex pipens (mosquito) ENSCPOP00000002113 Cavia porcellus (guinea pig) 77454 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000008476 Ciona savignyi (sedentary tunicate) 149303 Capitella spl (polychaete worm) DDB0229427 Dictyostelium discoideum (amoeba) 230543 Daphnia pulex (daphnia) ENSDARP00000078136 Danio rerio (zebra fish) ENSECAP00000022570 Equus caballus (horse) ENSGACP00000002749 Gymnopilus aculeatus (mushroom) ENSGALP00000009912 Gallus gallus (chicken) 186224 Hypsipyla robusta (cedar shoot borer) ENSP00000338673 Homo sapiens (human) ISCW015962-PA Ixodes scapularis (deer tick) 223686 Lottia gigantea (owl limpet) 14100 Monocosta brevicollis (choanoflagellate) ENSMODP00000004283 Monodelphis domestica (gray opossum) ENSMUSP00000045527 Mus musculus (house mouse) 237661 Nematostella vectensis (starlet anemone) XP_001603818.1 Nasonia vitripennis (wasp) ENSOANP00000007659 Ornithorynchus anatinus (platypus) ENSORLP00000019096 Oryzias latipes (japanese killifish) 14973 Ostreococcus tauri (green alga) PHUM002934-PA Pediculus humanus (human body louse) 231029 Physcomitrella patens (moss) ENSPPYP00000008646 Pongo pygmaeus (orangutan) 109337 Phytophthora sojae (root rot pathogen) 834350 Populus trichocarpa (black cottonwood) ENSPTRP00000014478 Pan troglodytes (chimpanzee) ENSRNOP00000021607 Rattus norvegicus (norway rat) Smp_103950 Schistosoma mansoni (trematode parasite) SPBC18H10.15 Schizosaccharomyces pombe (fission yeast) XP_783449.1 Strongylocentrotus purpuratus (purple sea urchin) XP_797002.1 Strongylocentrotus purpuratus (purple sea urchin) 28456 Trichoplax adhaerens (metazoa) XP_974492.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011693 Tetraodon nigroviridis (green spotted pufferfish) 261820 Thalassiosira pseudonana (marine diatom) ENSTRUP00000009877 Takifugu rubripes (pufferfish Takifugu) 3707.m00213 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000000377 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16107 ISCW015962 FBgn0239053 FBgn0223350 FBgn0207346 FBgn0197284 FBgn0175437 JGI_V11_230543 FBgn0072458 FBgn0148167 FBgn0142989 FBgn0127430 FBgn0117358 FBgn0089945 CPIJ002062 BGIBMGA006777 ACYPI003998 GB16146 AGAP005851 AAEL005191 PHUM380220 GLEAN_03488
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	35325 y1 sc* v1; P{TRiP.GL00232}attP2/TM3, Sb1
VDRC	v100299 P{KK107629}VIE-260B v32249 w1118; P{GD8076}v32249
Genomic Clones ( 2 )
	BACR06J01 BACR09J12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 59 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM29110 LP02532 RE37740
Other clones	SD02166
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02623
Other clones	34752 53804 118778 EC055432 EK165140 EK177916 EK194808 EK238123 RP003001514 RP003002942 RP003015354 RP003044486 RP003091379 RP003098325 RP003105000 RP003116131 RP003156230 RP003156534 RP003177415 RP003191965 RP003192040 RP003194888 RP003279068 RP003285150 RP003290396 RP003292159 RP003305204 RP003307942 RP003311612 RP003318001 RP003325141 RP003326545 RP003339257 RP003360383 RP003387421 RP003398438 RP003402200 RP003411271 RP003423843 RP003433189 RP003440893 RP003451554 RP003480708 RP003490731 RP003493681 RP003542650 RP003558700 RP003563634 RP003576038 RP003586620 RP003651465 RP003653574 RP004392175 RP004548161
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0013435 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36051
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Identified on the basis of sequence similarity to kinase subdomains VIb to IX of htl. (Sugaya et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078950 RefSeq (Proteins) • NP_523674 DDBJ / EMBL / GenBank • AAF58851 AAM71055 AAN71382 AC005974 BAA03886 BI240810 BT001627 D16402 Entrez Gene - A searchable database of RefSeq genes. • 36051 UniProtKB/TrEMBL • A1Z840 A1Z841 Q8IGS3 Q24294
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0013435 DRSC - Results from RNAi screens. • FBgn0013435 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013435 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1362-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0013435 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36051 InParanoid A subset of ortholog calls from InParanoid. • AAEL005191-PA Aedes aegypti (mosquito) AGAP005851-PA Anopheles gambiae (mosquito) XP_392973.3 Apis mellifera (honey bee) XP_001952546.1 Acyrthosiphon pisum (pea aphid) At5g63370.1 Arabidopsis thaliana (wall cress) 3387 Batrachochytrium dendrobatidis (chytrid fungus) 228782 Branchiostoma floridae (lancelet) XP_001893098.1 Brugia malayi (roundworm nematode) BGIBMGA006777-PA Bombyx mori (silk worm) ENSBTAP00000016228 Bos taurus (bovine) ENSBTAP00000044609 Bos taurus (bovine) ENSCAFP00000029349 Canis familiaris (dog) ENSCINP00000007891 Ciona intestinalis (sea squirt) CPIJ002062 Culex pipens (mosquito) ENSCPOP00000002113 Cavia porcellus (guinea pig) 77454 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000008476 Ciona savignyi (sedentary tunicate) 149303 Capitella spl (polychaete worm) DDB0229427 Dictyostelium discoideum (amoeba) 230543 Daphnia pulex (daphnia) ENSDARP00000078136 Danio rerio (zebra fish) ENSECAP00000022570 Equus caballus (horse) ENSGACP00000002749 Gymnopilus aculeatus (mushroom) ENSGALP00000009912 Gallus gallus (chicken) 186224 Hypsipyla robusta (cedar shoot borer) ENSP00000338673 Homo sapiens (human) ISCW015962-PA Ixodes scapularis (deer tick) 223686 Lottia gigantea (owl limpet) 14100 Monocosta brevicollis (choanoflagellate) ENSMODP00000004283 Monodelphis domestica (gray opossum) ENSMUSP00000045527 Mus musculus (house mouse) 237661 Nematostella vectensis (starlet anemone) XP_001603818.1 Nasonia vitripennis (wasp) ENSOANP00000007659 Ornithorynchus anatinus (platypus) ENSORLP00000019096 Oryzias latipes (japanese killifish) 14973 Ostreococcus tauri (green alga) PHUM002934-PA Pediculus humanus (human body louse) 231029 Physcomitrella patens (moss) ENSPPYP00000008646 Pongo pygmaeus (orangutan) 109337 Phytophthora sojae (root rot pathogen) 834350 Populus trichocarpa (black cottonwood) ENSPTRP00000014478 Pan troglodytes (chimpanzee) ENSRNOP00000021607 Rattus norvegicus (norway rat) Smp_103950 Schistosoma mansoni (trematode parasite) SPBC18H10.15 Schizosaccharomyces pombe (fission yeast) XP_783449.1 Strongylocentrotus purpuratus (purple sea urchin) XP_797002.1 Strongylocentrotus purpuratus (purple sea urchin) 28456 Trichoplax adhaerens (metazoa) XP_974492.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011693 Tetraodon nigroviridis (green spotted pufferfish) 261820 Thalassiosira pseudonana (marine diatom) ENSTRUP00000009877 Takifugu rubripes (pufferfish Takifugu) 3707.m00213 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000000377 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36051 modMine - Data generated by the modENCODE project. • FBgn0013435 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16107 ISCW015962 FBgn0239053 FBgn0223350 FBgn0207346 FBgn0197284 FBgn0175437 JGI_V11_230543 FBgn0072458 FBgn0148167 FBgn0142989 FBgn0127430 FBgn0117358 FBgn0089945 CPIJ002062 BGIBMGA006777 ACYPI003998 GB16146 AGAP005851 AAEL005191 PHUM380220 GLEAN_03488
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	cdc2rk (Herold et al., 2009) CG1362 (Morrison et al., 2000, Keleman et al., 2009.8.5, Herold et al., 2009, Ni et al., 2011.7.19) Dcdrk (Liu and Kipreos, 2000, Emori, 1993.6.7, Sugaya et al., 1994, )
Name Synonym	cdc2-related-kinase
Secondary FlyBase IDs
References ( 20 )
Research paper	Herold et al., 2009, Mol. Cell. Biol. 29(1): 281--301 Conservation of the protein composition and electron microscopy structure of Drosophila melanogaster and human spliceosomal complexes. [FBrf0207172] Brody et al., 2002, Mech. Dev. 113(1): 41--59 Identification of novel Drosophila neural precursor genes using a differential embryonic head cDNA screen. [FBrf0147137] Liu and Kipreos, 2000, Molec. Biol. Evol. 17(7): 1061--1074 Evolution of cyclin-dependent kinases (CDKs) and CDK-activating kinases (CAKs): differential conservation of CAKs in yeast and metazoa. [FBrf0128813] Sugaya et al., 1994, J. Biochem., Tokyo 115(1): 150--155 Identification of a novel Drosophila gene encoding a Cdc2-related protein kinase. [FBrf0074562]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Kiger et al., 2003, J. Biol. 2(4): Additional data file 1: The gene identity and primer sequences for dsRNAs used in the RNAi screens. [FBrf0174231] Morrison et al., 2000, J. Cell Biol. 150(2): Table S1. Drosophila protein kinases and phosphatases. [FBrf0132098]
Review	Manning et al., 2002, Trends Biochem. Sci. 27(10): 514--520 Evolution of protein kinase signaling from yeast to man. [FBrf0183159]
Personal communication to FlyBase	Ni et al., 2011.7.19, TRiP germline vector pVALIUM21. TRiP germline vector pVALIUM21. [FBrf0214641] Keleman et al., 2009.8.5, RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi-phiC31 construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0208510] Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
DNA/RNA sequence record	Emori, 1993.6.7, GenBank/EMBL/DDBJ: D16402 Fruitfly Dcdrk gene for Dcdrk kinase, complete cds. [FBrf0121105]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078] BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0067338]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]
Curated genome annotation	Li, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126682]