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Gene Dmel\mtd

General Information
Symbol	Dmel\mtd	Species	D. melanogaster
Name	mustard	Annotation symbol	CG32464
Feature type	protein_coding_gene	FlyBase ID	FBgn0013576
Gene Model Status	Current	Stock availability	24 publicly available
Also Known As	l(3)82Fd, L82
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	82F8-82F10	Sequence location	3R:1,095,838..1,176,165 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mustard is referred to in FlyBase by the symbol Dmel\mtd (CG32464, FBgn0013576). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: activation of innate immune response; defense response to Gram-negative bacterium; imaginal disc-derived wing morphogenesis. 35 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum; pigment cell. It has 24 annotated transcripts and 24 annotated polypeptides. Protein features are: Peptidoglycan-binding Lysin subgroup; Peptidoglycan-binding lysin domain; TLDc. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult Malpighian tubules, larval/adult salivary gland, adult spermathecae, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, adult heart, adult fat body, larval trachea, adult ovary, adult testis, larval/adult carcass. Gene sequence location is 3R:1095838..1176165.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Alleles mtd[MI06923] mtd[MI05800]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 82F8-82F10
Experimentally Determined Cytological Location
Cytogenetic map Notes References 82F-82F     (Stowers, 1999.2.3)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mtd for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39 Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Annotated transcripts do not represent all supported alternative splices within 5' UTR. Low-frequency RNA-Seq exon junction(s) not annotated. Gene model includes transcripts encoding non-overlapping portions of the full CDS.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mtd-RA FBtr0078817  NM_170644   4719   210 mtd-RAA FBtr0333695  NM_001275350   3789   871 mtd-RB FBtr0078810  NM_143760   8072   1270 mtd-RC FBtr0078815  NM_170643   2303   267 mtd-RF FBtr0078813  NM_170641   3783   869 mtd-RG FBtr0078818  NM_206429   4780   1033 mtd-RH FBtr0078816  NM_169045   1675   192 mtd-RI FBtr0078814  NM_170642   4838   213 mtd-RJ FBtr0078811  NM_169038   5167   1270 mtd-RK FBtr0078812  NM_170640   4502   1055 mtd-RM FBtr0100197  NM_001031978   4083   1012 mtd-RN FBtr0100199  NM_001031977   5214   1270 mtd-RO FBtr0110932  NM_001043214   4332   1025 mtd-RP FBtr0110933  NM_001043213   5373   1314 mtd-RQ FBtr0273430  NM_001144534   2394   192 mtd-RR FBtr0273431  NM_001144535   4175   789 mtd-RS FBtr0273432  NM_001144536   4651   1106 mtd-RT FBtr0273433  NM_001144537   5170   1106 mtd-RU FBtr0273434  NM_169039   5169   1246 mtd-RV FBtr0306694  NM_001259999   5689   1344 mtd-RW FBtr0306695  NM_001260000   6314   1180 mtd-RX FBtr0308580  NM_169047   5976   1127 mtd-RY FBtr0308581  NM_001260001   4905   1158 mtd-RZ FBtr0333694  NM_001275349   2464   686
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mtd-PA   FBpp0078460   23.7   210   4.92     NP_730915   AAF52048 mtd-PAA   FBpp0305848   94.7   871   4.83     NP_001262279   AGB95662 mtd-PB   FBpp0078453   138.8   1270   5.36     NP_652017   AAF52045 mtd-PC   FBpp0078458   30.1   267   5.77     NP_730914   AAF52047 mtd-PF   FBpp0078456   94.4   869   4.81     NP_730912   AAN13272 mtd-PG   FBpp0089229   112.5   1033   5.06     NP_996151   AAN13276 mtd-PH   FBpp0078459   21.7   192   4.87     NP_730916   AAN13274 mtd-PI   FBpp0078457   24.1   213   6.63     NP_730913   AAN13273 mtd-PJ   FBpp0078454   138.8   1270   5.36     NP_730909   AAN13269 mtd-PK   FBpp0078455   114.7   1055   5.11     NP_730911   AAN13271 mtd-PM   FBpp0099567   110.2   1012   4.93     NP_001027149   AAZ52516 mtd-PN   FBpp0099569   138.8   1270   5.36     NP_001027148   AAZ52515 mtd-PO   FBpp0110232   111.5   1025   4.99     NP_001036679   ABI31140 mtd-PP   FBpp0110233   143.2   1314   5.31     NP_001036678   ABI31139 mtd-PQ   FBpp0271938   21.7   192   4.87     NP_001138006   ACL83465 mtd-PR   FBpp0271939   85.8   789   4.72     NP_001138007   ACL83466 mtd-PS   FBpp0271940   120.1   1106   5.64     NP_001138008   ACL83467 mtd-PT   FBpp0271941   120.1   1106   5.64     NP_001138009   ACL83468 mtd-PU   FBpp0271942   136.1   1246   5.22     NP_730910   AAN13270 mtd-PV   FBpp0297633   146.4   1344   5.45     NP_001246928   AFH06247 mtd-PW   FBpp0297634   127.7   1180   5.72     NP_001246929   AFH06248 mtd-PX   FBpp0300804   121.9   1127   5.06     NP_730918   AAF52044 mtd-PY   FBpp0300805   126.8   1158   5.24     NP_001246930   AFH06249 mtd-PZ   FBpp0305847   72.8   686   4.74     NP_001262278   AGB95661
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidoglycan-binding lysin domain (IPR018392) Peptidoglycan-binding Lysin subgroup (IPR002482) TLDc (IPR006571)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141141   AA540055   AA697732   AA698507   AA699133   AE014297 AAF52044   AE014297 AAF52045   AE014297 AAF52047   AE014297 AAF52048   AE014297 AAN13269   AE014297 AAN13270   AE014297 AAN13271   AE014297 AAN13272   AE014297 AAN13273   AE014297 AAN13274   AE014297 AAN13276   AE014297 AAZ52515   AE014297 AAZ52516   AE014297 ABI31139   AE014297 ABI31140   AE014297 ACL83465   AE014297 ACL83466   AE014297 ACL83467   AE014297 ACL83468   AF125384 AAD28508   AF125385 AAD28509   AF125386 AAD28510   AF125387 AAD28511   AF125388 AAD28512   AF125389 AAD28513   AF125390 AAD28514   AF171859   AE014297 AFH06247   AE014297 AFH06248   AE014297 AFH06249   AE014297 AGB95661   AE014297 AGB95662   AI064043   AI134267   AI295633   AI388952   AI402384   AI402733   AI533077   AI542588   AW940423   AW944576   AY051449 AAK92873   AY118658 AAM50027   BE976201   BF489268   BF492835   BF492836   BF493675   BF503063   BF505337   BG632181   BG632976   BH759354   BI162600   BI162601   BI165393   BI170246   BI170886   BI215570   BI230007   BI232309   BI234288   BI237415   BI237862   BI241018   BI242634   BI354825   BI354867   BI356873   BI358000   BI358009   BI363646   BI364485   BI364837   BI371800   BI373718   BI374421   BI374552   BI482865   BI483041   BI486922   BI563624   BI565135   BI565146   BI565209   BI566221   BI566420   BI566422   BI566642   BI566783   BI567131   BI567550   BI567758   BI568257   BI569523   BI570111   BI571202   BI571349   BI571678   BI574243   BI574822   BI574896   BI575028   BI575266   BI576405   BI576709   BI582852   BI583117   BI583173   BI583526   BI583761   BI584393   BI584721   BI584941   BI585412   BI586040   BI586157   BI587433   BI588657   BI588765   BI588898   BI588929   BI589184   BI589634   BI589790   BI589976   BI590688   BI590694   BI590707   BI590720   BI592344   BI592602   BI593087   BI593216   BI604415   BI604672   BI605258   BI606851   BI606865   BI607841   BI608362   BI609001   BI609625   BI611253   BI612733   BI613706   BI613780   BI614158   BI614391   BI616389   BI616455   BI616456   BI616946   BI617273   BI617351   BI617361   BI618448   BI618588   BI619654   BI620401   BI620424   BI620857   BI620860   BI620943   BI622167   BI622266   BI625311   BI626099   BI627680   BI629135   BI629241   BI629724   BI629821   BI629859   BI632352   BI633854   BI635838   BI638167   BP550411   BP550412   BT081412   BT099596   BT099608   BT099742   BT100098   BT122138   BT125678   BT126214   BT126361   CA803762   CA804412   CA805812   CA806847   CK657416   CK660020   CL527759   CO153659   CO182888   CO186547   CO187218   CO188723   CO189899   CO266345   CO267181   CO267970   CO268964   CO269655   CO270064   CO271932   CO272584   CO272764   CO274800   CO274822   CO275734   CO275951   CO276485   CO279376   CO279521   CO280578   CO281051   CO281086   CO282286   CO285574   CO286695   CO294290   CO297267   CO297327   CO297566   CO297627   CO298718   CO302300   CO304564   CO304579   CO305087   CO307145   CO307978   CO308359   CO309126   CO311088   CO312547   CO314253   CO314436   CO316841   CO316928   CO317420   CO319425   CO320395   CO320569   CO321067   CO324664   CO326281   CO327765   CO330051   CO330296   CO331523   CO339132   CO339142   CO343489   CO343515   CO344067   CZ469499   CZ469500   CZ473697   CZ477271   CZ478322   CZ479641   CZ483070   CZ483071   CZ488679   DN154088   EC060747   EC062405   EC063361   EC065492   EC066200   EC069419   EC071262   EC073028   EC073148   EC073529   EC076441   EC076763   EC080425   EC082628   EC083046   EC083082   EC083573   EC084415   EC087745   EC088098   EC194834   EC197934   EC198553   EC205135   EC208507   EC208842   EC209500   EC210509   EC211315   EC212767   EC213236   EC214194   EC216287   EC221502   EC221693   EC222902   EC226402   EC226889   EC227636   EC229689   EC236688   EC237388   EC238186   EC238538   EC243386   EC245927   EC248274   EC248720   EC249664   EC249996   EC250229   EC250777   EC251691   EC253522   EC253736   EC253859   EC254384   EC254953   EC256290   EC257818   ES692223   EV575941   EV578094   EV582489   EV584584   EV591209   GH941189   GH942677   GH943682   GH944340   GH945772   GH945791   GH947609   GH948818   GH948990   GH949259   GH950698   GH952081   GH956729   GH958774   GH959398   GH959513   GH959708   GH960985   GH961912   GH963875   GH964400   GH964486   GH965055   GH967801   GH968979   GH969591   GH970959   GH971037   GH973635   GH975748   GH980804   GH981228   GH981901   GH982429   GH984637
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KNC5 Q7KTR7 Q7KTR8 Q8IPN6 Q8IPN7 Q8IPN8 Q8IPN9 Q8MSQ5 Q9VNA1 Q9VNA2 A4V2F2 Q4ABH3 B7Z0T6 B7Z0T3 Q0KIB9
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   dorsal ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi organism | gap expression pattern   (Fisher et al., 2012) ventral ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) dorsal ectoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) germline cell   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) tracheal primordium   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval midgut   (Fisher et al., 2012) yolk nucleus   (Fisher et al., 2012) RT-PCR Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval midgut   (Wang et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Wang et al., 2012) nucleus inferred from direct assay (Wang et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult Malpighian tubules, larval/adult salivary gland, adult spermathecae, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, adult heart, adult fat body, larval trachea, adult ovary, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female    44 head, virgin 4-day female    39 head, virgin 20-day female    27 head, mated 1-day female    40 head, mated 4-day female    33 head, mated 20-day female    27 head, mated 1-day male    65 head, mated 4-day male    59 head, mated 20-day male    50 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    99 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    22 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    22 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult    20 ovary, virgin 4-day female    39 ovary, mated 4-day female    29 testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female  (44) head, virgin 4-day female  (39) head, virgin 20-day female  (27) head, mated 1-day female  (40) head, mated 4-day female  (33) head, mated 20-day female  (27) head, mated 1-day male  (65) head, mated 4-day male  (59) head, mated 20-day male  (50) salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  (99) digestive system, larvae L3 wandering    19 digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    22 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    22 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult    20 ovary, virgin 4-day female  (39) ovary, mated 4-day female  (29) testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female    44 head, virgin 4-day female    39 head, virgin 20-day female    27 head, mated 1-day female    40 head, mated 4-day female    33 head, mated 20-day female    27 head, mated 1-day male    65 head, mated 4-day male    59 head, mated 20-day male    50 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    99 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    22 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    22 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult    20 ovary, virgin 4-day female    39 ovary, mated 4-day female    29 testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female    44 head, virgin 4-day female    39 head, virgin 20-day female    27 head, mated 1-day female    40 head, mated 4-day female    33 head, mated 20-day female    27 head, mated 1-day male    65 head, mated 4-day male    59 head, mated 20-day male    50 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    99 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    22 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    22 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult    20 ovary, virgin 4-day female    39 ovary, mated 4-day female    29 testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female    44 head, virgin 4-day female    39 head, virgin 20-day female    27 head, mated 1-day female    40 head, mated 4-day female    33 head, mated 20-day female    27 head, mated 1-day male    65 head, mated 4-day male    59 head, mated 20-day male    50 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    99 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    22 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    22 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult    20 ovary, virgin 4-day female    39 ovary, mated 4-day female    29 testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female  (44) head, virgin 4-day female  (39) head, virgin 20-day female  27 head, mated 1-day female  (40) head, mated 4-day female  (33) head, mated 20-day female  27 head, mated 1-day male  (65) head, mated 4-day male  (59) head, mated 20-day male  (50) salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  (99) digestive system, larvae L3 wandering    19 digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    22 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    22 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult    20 ovary, virgin 4-day female  (39) ovary, mated 4-day female  29 testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female    44 head, virgin 4-day female    39 head, virgin 20-day female    27 head, mated 1-day female    40 head, mated 4-day female    33 head, mated 20-day female    27 head, mated 1-day male    65 head, mated 4-day male    59 head, mated 20-day male    50 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    99 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    22 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    22 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult    20 ovary, virgin 4-day female    39 ovary, mated 4-day female    29 testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    21 central nervous system, pupae P8    19 head, virgin 1-day female    44 head, virgin 4-day female    39 head, virgin 20-day female    27 head, mated 1-day female    40 head, mated 4-day female    33 head, mated 20-day female    27 head, mated 1-day male    65 head, mated 4-day male    59 head, mated 20-day male    50 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    99 digestive system, larvae L3 wandering    19 digestive system, 1-day adult    19 digestive system, 4-day adult    19 digestive system, 20-day adult    22 fat body, larvae L3 wandering    2 fat body, white prepupae    14 fat body, pupae P8    22 carcass, larvae L3 wandering    13 carcass, 1-day adult    18 carcass, 4-day adult    21 carcass, 20-day adult    20 ovary, virgin 4-day female    39 ovary, mated 4-day female    29 testis, mated 4-day male    8 accessory gland, mated 4-day male    18 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    13 embryo 04-06hr    10 embryo 06-08hr    13 embryo 08-10hr    12 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    17 embryo 18-20hr    22 embryo 20-22hr    22 embryo 22-24hr    24 larva L1    16 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    15 white prepupae new    30 white prepupae 12hr    46 white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    18 pupae 4d postWPP    27 adult male 01day    22 adult male 05day    22 adult male 30day    19 adult female 01day    19 adult female 05day    25 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (36) embryo 02-04hr    13 embryo 04-06hr    10 embryo 06-08hr    13 embryo 08-10hr    12 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    17 embryo 18-20hr    22 embryo 20-22hr    22 embryo 22-24hr    24 larva L1    16 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    15 white prepupae new  (30) white prepupae 12hr  (46) white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    18 pupae 4d postWPP  (27) adult male 01day    22 adult male 05day    22 adult male 30day    19 adult female 01day    19 adult female 05day    25 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    13 embryo 04-06hr    10 embryo 06-08hr    13 embryo 08-10hr    12 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    17 embryo 18-20hr    22 embryo 20-22hr    22 embryo 22-24hr    24 larva L1    16 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    15 white prepupae new    30 white prepupae 12hr    46 white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    18 pupae 4d postWPP    27 adult male 01day    22 adult male 05day    22 adult male 30day    19 adult female 01day    19 adult female 05day    25 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    13 embryo 04-06hr    10 embryo 06-08hr    13 embryo 08-10hr    12 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    17 embryo 18-20hr    22 embryo 20-22hr    22 embryo 22-24hr    24 larva L1    16 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    15 white prepupae new    30 white prepupae 12hr    46 white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    18 pupae 4d postWPP    27 adult male 01day    22 adult male 05day    22 adult male 30day    19 adult female 01day    19 adult female 05day    25 adult female 30day    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    13 embryo 04-06hr    10 embryo 06-08hr    13 embryo 08-10hr    12 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    17 embryo 18-20hr    22 embryo 20-22hr    22 embryo 22-24hr    24 larva L1    16 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    15 white prepupae new    30 white prepupae 12hr    46 white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    18 pupae 4d postWPP    27 adult male 01day    22 adult male 05day    22 adult male 30day    19 adult female 01day    19 adult female 05day    25 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (36) embryo 02-04hr    13 embryo 04-06hr    10 embryo 06-08hr    13 embryo 08-10hr    12 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    17 embryo 18-20hr    22 embryo 20-22hr    22 embryo 22-24hr    24 larva L1    16 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    15 white prepupae new  30 white prepupae 12hr  (46) white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    18 pupae 4d postWPP  27 adult male 01day    22 adult male 05day    22 adult male 30day    19 adult female 01day    19 adult female 05day    25 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    13 embryo 04-06hr    10 embryo 06-08hr    13 embryo 08-10hr    12 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    17 embryo 18-20hr    22 embryo 20-22hr    22 embryo 22-24hr    24 larva L1    16 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    15 white prepupae new    30 white prepupae 12hr    46 white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    18 pupae 4d postWPP    27 adult male 01day    22 adult male 05day    22 adult male 30day    19 adult female 01day    19 adult female 05day    25 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    36 embryo 02-04hr    13 embryo 04-06hr    10 embryo 06-08hr    13 embryo 08-10hr    12 embryo 10-12hr    14 embryo 12-14hr    15 embryo 14-16hr    13 embryo 16-18hr    17 embryo 18-20hr    22 embryo 20-22hr    22 embryo 22-24hr    24 larva L1    16 larva L2    12 larva L3 12hr old    9 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    15 white prepupae new    30 white prepupae 12hr    46 white prepupae 24hr    20 pupae 2d postWPP    16 pupae 3d postWPP    18 pupae 4d postWPP    27 adult male 01day    22 adult male 05day    22 adult male 30day    19 adult female 01day    19 adult female 05day    25 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    21 embryonic 1182-4H    16 embryonic GM2    48 embryonic Kc167    37 embryonic S1    15 embryonic S3    29 leg disc CME L1    29 wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    17 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    39 ovary fGS/OSS    10 ovary OSC    10 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (28) Schneider line 2 Sg4    21 embryonic 1182-4H    16 embryonic GM2  (48) embryonic Kc167  (37) embryonic S1    15 embryonic S3  (29) leg disc CME L1  (29) wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9    12 wing disc ML-DmD16-c3  26 wing disc ML-DmD21    17 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3  (32) eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2  (39) ovary fGS/OSS    10 ovary OSC    10 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    21 embryonic 1182-4H    16 embryonic GM2    48 embryonic Kc167    37 embryonic S1    15 embryonic S3    29 leg disc CME L1    29 wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    17 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    39 ovary fGS/OSS    10 ovary OSC    10 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    21 embryonic 1182-4H    16 embryonic GM2    48 embryonic Kc167    37 embryonic S1    15 embryonic S3    29 leg disc CME L1    29 wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    17 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    39 ovary fGS/OSS    10 ovary OSC    10 ovary OSS    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    21 embryonic 1182-4H    16 embryonic GM2    48 embryonic Kc167    37 embryonic S1    15 embryonic S3    29 leg disc CME L1    29 wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    17 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    39 ovary fGS/OSS    10 ovary OSC    10 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  28 Schneider line 2 Sg4    21 embryonic 1182-4H    16 embryonic GM2  (48) embryonic Kc167  (37) embryonic S1    15 embryonic S3  29 leg disc CME L1  29 wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9    12 wing disc ML-DmD16-c3  26 wing disc ML-DmD21    17 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3  32 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2  (39) ovary fGS/OSS    10 ovary OSC    10 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    21 embryonic 1182-4H    16 embryonic GM2    48 embryonic Kc167    37 embryonic S1    15 embryonic S3    29 leg disc CME L1    29 wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    17 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    39 ovary fGS/OSS    10 ovary OSC    10 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    28 Schneider line 2 Sg4    21 embryonic 1182-4H    16 embryonic GM2    48 embryonic Kc167    37 embryonic S1    15 embryonic S3    29 leg disc CME L1    29 wing disc CME-W2    16 wing disc ML-DmD8    22 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    26 wing disc ML-DmD21    17 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    32 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    17 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    13 CNS ML-DmBG2-c2    13 tumorous blood cells mbn2    39 ovary fGS/OSS    10 ovary OSC    10 ovary OSS    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    12 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    12 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  (31) Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult  (31) Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult  (28) Ethanol 2.5% 3 hrs, larvae L3  (29) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (27) Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult  (29) Paraquat 10 mM 48 hrs, 4-day adult  (29) Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    12 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    12 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    12 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    12 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult  31 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult  31 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult  28 Ethanol 2.5% 3 hrs, larvae L3  29 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  27 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult  29 Paraquat 10 mM 48 hrs, 4-day adult  29 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    12 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    12 heat shock, 4-day adult    14 Cadmium 50 mM 6 hrs, larvae L3    7 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    15 Cadmium 100 mM 48 hrs, 4-day adult    31 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    28 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    6 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    27 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • GH11677 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013576 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32464-RD;CG32464-RD;CG32464-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for mtd Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal mtd3 mtdCA07520 lethal | adult stage | recessive mtd5 mtd8 lethal | recessive mtd1 mtd2 mtd4 mtd5 mtd6 mtd7 mtd8 viable mtd3 mtdEY04695 viable, with Scer\GAL4pnr-MD237 mtdGD4766 Sterility Allele fertile mtd3 mtdEY04695 Other Phenotypes Allele eye color defective | recessive mtd1 mtd2 mtd3 stress response defective mtde00435 mtdEP13 mtdEP18 mtdEY04695 mtdf06038 mtdKG02600 mtdScer\UAS.RH stress response defective, with Scer\GAL4da.G32 mtdScer\UAS.RH visible, with Scer\GAL4pnr-MD237 mtdGD4766 wild-type mtdhs.PS Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 mtdGD4766 pigment cell mtd1 mtd2 mtd3 trichogen cell, with Scer\GAL4pnr-MD237 mtdGD4766
Classical Alleles ( 26 )
For All Classical Alleles Show
Allele of mtd Class Mutagen Stocks Known lesion mtd1 X ray 2 Yes mtd4 X ray 2 Yes mtd3 ethyl nitrosourea 1 -- mtd5-HA-3069 1 -- mtdBG01597 1 -- mtdc04769 piggyBac transposase 1 -- mtdd04038 P-element activity 1 -- mtdd10462 P-element activity 1 -- mtde00435 piggyBac transposase 1 Yes mtdEY04695 gain of function allele P-element activity 1 Yes mtdf00607 piggyBac transposase 1 -- mtdf06038 piggyBac transposase 1 Yes mtdG7056 P-element activity 1 -- mtdKG02600 P-element activity 1 Yes mtdMI02920 1 -- mtdMI05800 1 -- mtdMI06923 1 -- mtd2 X ray 0 Yes mtd5 X ray 0 Yes mtd6 X ray 0 -- mtd7 X ray 0 Yes mtd8 X ray 0 Yes mtdCA07520 P-element activity 0 Yes mtde01819 piggyBac transposase 0 -- mtdEP13 0 Yes mtdEP18 0 Yes
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mtd Class Mutagen Stocks Known lesion mtdGD4766 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mtdGL00598 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mtdGL00665 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mtdHMS01608 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mtdHMS01666 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes mtdhs.PS in vitro construct - regulatory fusion 0 Yes mtdNIG.10199R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes mtdScer\UAS.RC.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mtdScer\UAS.RC in vitro construct - regulatory fusion 0 Yes mtdScer\UAS.RH.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes mtdScer\UAS.RH in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)3-4 (Carpenter, 1999, Carpenter, 1994, Wang et al., 2012) Df(3R)6-7 (Carpenter, 1999, Carpenter, 1994) Df(3R)ME15 (Carpenter, 1999, Carpenter, 1994)
Not disrupted in	Df(3R)110 (Carpenter, 1999, Carpenter, 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{NIG.10199R} NA P{TRiP.GL00665} NA P{TRiP.HMS01666} NA P{UAS-mtd.RC.HA} NA P{UAS-mtd.RC} NA P{UAS-mtd.RH.HA} NA P{UAS-mtd.RH} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Tim17b1G7056 NA P{EPgy2}mtdEY04695 NA P{XP}mtdd04038 NA P{XP}mtdd10462 NA miscellaneous insertions Mi{MIC}mtdMI02920 NA Mi{MIC}mtdMI05800 NA Mi{MIC}mtdMI06923 NA P{GT1}mtdBG01597 NA P{PTT-GA}mtdCA07520 NA P{RS5}mtd5-HA-3069 NA P{SUPor-P}mtdKG02600 NA PBac{PB}mtdc04769 NA PBac{RB}mtde00435 NA PBac{RB}mtde01819 NA PBac{WH}mtdf00607 NA PBac{WH}mtdf06038 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
activation of innate immune response inferred from mutant phenotype (Wang et al., 2012) defense response to Gram-negative bacterium inferred from mutant phenotype (Wang et al., 2012) imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Carreira et al., 2011)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Wang et al., 2012) nucleus inferred from direct assay (Wang et al., 2012)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell wall macromolecule catabolic process inferred from electronic annotation with InterPro:IPR002482, InterPro:IPR018392 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
mtd - CG7737 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) mtd - HIP-R anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) mtd - Vha44 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mtd allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69697 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0013576 DroID - A comprehensive database of gene and protein interactions. • FBgn0013576 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45467
Orthologs
OrthoDB Orthologs (33) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6B8JZJ Dipteran inclusive ortholog search EOG6J11H9 Insect inclusive ortholog search EOG6C86NF Arthropod inclusive ortholog search EOG6N02W1 Metazoa inclusive ortholog search EOG647TM7
Orthologs in Drosophila Species (EOG6B8JZJ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\mtd     Drosophila simulans   Dsim\GD19631     Drosophila sechellia   Dsec\GM10647     Drosophila erecta   Dere\GG11075     Drosophila yakuba   Dyak\GE25295     Drosophila ananassae   Dana\GF16062     Drosophila pseudoobscura pseudoobscura   Dpse\GA27405     Drosophila persimilis   Dper\GL22191     Drosophila willistoni   Dwil\GK14284     Drosophila virilis   Dvir\GJ11013     Drosophila mojavensis   Dmoj\GI10211     Drosophila grimshawi   Dgri\GH22687
Orthologs in non-Drosophila Dipterans (EOG6J11H9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Anopheles gambiae Malaria mosquito  Agam\AGAP001751   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013416
Orthologs in non-Dipteran Insects (EOG6C86NF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46739   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003628   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG003626   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19248   Atta cephalotes Leafcutter ant  Acep\ACEP25485   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20931   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12528   Linepithema humile Argentine ant  Lhum\LH14839   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15827   Solenopsis invicta Red fire ant  Sinv\SINV20803   Acyrthosiphon pisum Pea aphid  Apim\ACYPI085401   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002835   Bombyx mori Silkmoth  Bmor\BGIBMGA007564   Pediculus humanus Human body louse  Phum\PHUM489560   Tribolium castaneum Red flour beetle  Tcas\TC013055
Orthologs in non-Insect Arthropods (EOG6N02W1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Slc22a13   Daphnia pulex Water flea  Dpux\JGI_V11_303503   Ixodes scapularis Deer tick  Isca\ISCW011526
Orthologs in non-Arthropod Metazoa (EOG647TM7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Danio rerio Zebrafish  Drer\wu:fb25h12
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (5) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM10650 Drosophila erecta Dere\GG11111 Drosophila yakuba Dyak\GE25299 Drosophila pseudoobscura pseudoobscura Dpse\GA27407 Drosophila persimilis Dper\GL22193
Stocks & Reagents
Stocks Listed in FlyBase ( 24 )
Bloomington	43891 y1 w*; Mi{MIC}mtdMI06923 12845 w1118; P{GT1}BG01597a P{GT1}mtdBG01597 16612 y1 w67c23; P{EPgy2}mtdEY04695 38894 y1 sc* v1; P{TRiP.GL00665}attP2
Harvard	- P{XP}mtdd04038 - P{XP}mtdd10462 - PBac{PB}mtdc04769 - PBac{RB}mtde00435 - PBac{WH}mtdf00607 - PBac{WH}mtdf06038
Kyoto	125793 w1118; P{RS5}mtd5-HA-3069
VDRC	v12781 w1118; P{GD4766}v12781/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR01D10 BACR42H10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 328 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT17919 GH11677 RE01794 RE12121 RH50583 SD08996
Other clones	AF171859 DPiM_GH11677 FI14548 LD05964 MIP07034 MIP19716 RE01508
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01233 AT02004 AT07544 AT18968 AT25220 GH04293 GH04796 GH17523 GH20014 GH21595 GH22020 GM28435 GM28655 HL03069 HL04830 HL07769 LD19396 LP09319 LP18238 LP23680 RE05279 RE11639 RE12489 RE22114 RE27923 RE28357 RE29969 RE33641 RE34179 RE37984 RE40026 RE43139 RE44646 RE44658 RE48552 RE49612 RE50028 RE58793 RE61102 RE62007 RE62176 RE65648 RE65876 RE70410 RH01616 RH02364 RH03102 RH03279 RH03514 RH04343 RH04349 RH04364 RH04379 RH06035 RH06202 RH06948 RH09993 RH10341 RH10985 RH11184 RH11801 RH12774 RH13729 RH14430 RH17437 RH21269 RH21576 RH21708 RH22158 RH22446 RH22991 RH23578 RH23984 RH24284 RH24974 RH25760 RH26007 RH27062 RH27445 RH27587 RH28110 RH30048 RH30181 RH30352 RH30390 RH30522 RH31536 RH32960 RH33323 RH34292 RH35411 RH35660 RH35662 RH36345 RH36527 RH36986 RH37970 RH38335 RH39665 RH41679 RH42925 RH43018 RH43466 RH43752 RH46323 RH46410 RH46412 RH47125 RH47548 RH47658 RH47672 RH49288 RH49454 RH50731 RH51544 RH51569 RH52106 RH52110 RH52211 RH54001 RH54108 RH57951 RH58079 RH58630 RH58740 RH58786 RH62826 RH62837 RH62916 RH65648 RH66635 RH69043 RH69758 RH70117 RH70835 RH73687 RH73708 SD04773 SD17345 SD20387 SD26113 SD28030
Other clones	249 695 9398 13675 13707 15402 17554 21350 31902 34429 35406 37409.2 37787 44715 53217 54231 54369 55670 66471 76436 83110 100656 102495 103512 104510 107104 108825 117379 117765 118482 148220 153173 153744 157289 161751 161996 164648 173755 180791 192044 192105 214243.67 214243.68 214339.69 214371.76 214409.70 214477.61 214531.62 214535.72 273124 bs48a10 CK01.22D.D4 CK01.31C.C10 CK01.50D.D1 CK01.56B.A4 CK01.118C.F7 CK01.125A.D10 CK01.126D.H12 CK01.142A.F12 CK01.145A.F7 CK01254 Dmel_dig_005817_0595_1126 Dmel_dig_012993_0644_1914 Dmel_dig_016846_0632_0654 Dmel_dig_016857_0589_1377 Dmel_neb_012508_0349_2894 EC24225 EK020846 EK027332 EK041713 EK045534 EK063601 EK089824 EK093207 EK095447 EK097262 EK105224 EK107719 EK108319 EK115524 EK115548 EK118456 EK119224 EK121119 EK134202 EK134963 EK146115 EK149012 EK154402 EK155852 EK155940 EK160140 EK169503 EK170106 EK170225 EK173560 EK175051 EK183843 EK194460 EK206510 EK216522 EK216705 EK223342 EK229239 EK235533 EK236243 EK245124 EK245210 EK247301 EK253729 EK256325 EK257722 EK260357 EK266027 EK266311 EK267950 EK278102 EK284709 EK286312 EK290243 EK294432 EK294921 EK300044 EN02530 EP00927 EP00941 EP03555 EP08006 EP16855 EP16941 EP18621 ESG015b.E21_C10 ESG0110b.E21_H04 ESG0113c.B21.1_A11 ESG0119d.B21_E07 FGM207A05 RC0-DA0006-130700-021-C03 RE01876 RP004023882 RP004072005 RP004148853 RP004168797 RP004188631 RP004190794 RP004193198 RP004196085 RP004207495 RP004221000 RP004226564 RP004226810 RP004226990 RP004234548 RP004236815 RP004242157 RP004249047 RP004257998 RP004269538 RP004335532 RP004378669 RP004418336 RP004419694 RP004439139 RP004447759 RP004463137 RP004496122 RP004503070 RP004504278 RP004510123 RP004530027 RP004540415 RP004554861 RP004557720 RP004559456
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0013576 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45467
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: mtd l(3)82Fd (Wang et al., 2012)
Source for database merge of	Source for merge of: l(3)82Fd anon-EST:Posey263 (FlyBase Genome Annotators, 2005) Source for merge of: l(3)82Fd CG10196 (FlyBase, 1996-) Source for merge of: l(3)82Fd CG10199 (Bayraktaroglu, 2000.4.12)
Additional comments	Annotations CG10196, CG10199 merged as CG32464 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of l(3)82Fd CG10196 was a shared cDNA (date:010720). (FlyBase, 1996-)
Other Comments
	The 82F puff does not puff in l(3)82Fd4 flies suggesting that l(3)82Fd is the puff gene itself. (Carpenter, 1999) The broad developmental expression pattern of l(3)82Fd suggests it is controlled by both ecdysone-dependent and ecdysone-independent regulatory mechanisms. (Stowers et al., 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143760 NM_169038 NM_169039 NM_169045 NM_169047 NM_170640 NM_170641 NM_170642 NM_170643 NM_170644 NM_206429 NM_001031977 NM_001031978 NM_001043213 NM_001043214 NM_001144534 NM_001144535 NM_001144536 NM_001144537 NM_001259999 NM_001260000 NM_001260001 NM_001275349 NM_001275350 RefSeq (Proteins) • NP_652017 NP_730909 NP_730910 NP_730911 NP_730912 NP_730913 NP_730914 NP_730915 NP_730916 NP_730918 NP_996151 NP_001027148 NP_001027149 NP_001036678 NP_001036679 NP_001138006 NP_001138007 NP_001138008 NP_001138009 NP_001246928 NP_001246929 NP_001246930 NP_001262278 NP_001262279 DDBJ / EMBL / GenBank • AAD28508 AAD28509 AAD28510 AAD28511 AAD28512 AAD28513 AAD28514 AAF52044 AAF52044.2 AAF52045 AAF52045.2 AAF52047 AAF52047.1 AAF52048 AAF52048.2 AAK92873 AAM50027 AAN13269 AAN13269.1 AAN13270 AAN13270.1 AAN13271 AAN13271.1 AAN13272 AAN13272.1 AAN13273 AAN13273.1 AAN13274 AAN13274.1 AAN13276 AAN13276.2 AAZ52515 AAZ52516 ABI31139 ABI31140 ACL83465 ACL83466 ACL83467 ACL83468 AF125384 AF125385 AF125386 AF125387 AF125388 AF125389 AF125390 AF171859 AFH06247 AFH06248 AFH06249 AGB95661 AGB95662 AI134267 AI542588 AW940423 AW944576 AY051449 AY118658 BH759354 CL527759 CZ469499 CZ469500 CZ473697 CZ477271 CZ478322 CZ479641 CZ483070 CZ483071 CZ488679 Entrez Gene - A searchable database of RefSeq genes. • 45467 UniProtKB/TrEMBL • A4V2F2 B7Z0T3 B7Z0T6 Q0KIB9 Q4ABH3 Q7KNC5 Q7KTR7 Q7KTR8 Q8IPN6 Q8IPN7 Q8IPN8 Q8IPN9 Q8MSQ5 Q9VNA1 Q9VNA2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidoglycan-binding lysin domain (IPR018392) Peptidoglycan-binding Lysin subgroup (IPR002482) TLDc (IPR006571) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH11677
Linkouts
	BioGRID - A database of protein and genetic interactions • 69697 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0013576 DroID - A comprehensive database of gene and protein interactions. • FBgn0013576 DRSC - Results from RNAi screens. • FBgn0013576 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013576 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32464-RD;CG32464-RD;CG32464-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0013576 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45467 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45467 modMine - Data generated by the modENCODE project. • FBgn0013576
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	anon-EST:Posey263 (Ashburner, 2004.6.30, ) CG10196   CG10199 (Whitfield, 2000.5.24, ) CG32464 (Deloger et al., 2009, Ni et al., 2011.7.19, Jiang et al., 2008, Ni et al., 2010.12.1) L82 (Sun et al., 2003, Stowers, 1999.2.3, Stowers, 1999.2.3, Stowers, 1999.2.3, Stowers, 1999.2.3, Stowers, 1999.2.3, Stowers, 1999.2.3, Stowers, 1999.2.3, Stowers et al., 1999, ) l(3)82Fd (Buszczak et al., 2007, Hazelett et al., 2009, Turner et al., 2011, FlyBase Curators, 2008, Brandt et al., 2008, Carreira et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Smibert et al., 2012) L(3)82Fd (Deloger et al., 2009) l(3)82FD (Tuxworth et al., 2011) mtd (Wang et al., 2012)
Name Synonym	l(3)82Fd   late puff gene at 82F (Stowers et al., 1999) mustard (Wang et al., 2012)
Secondary FlyBase IDs
	FBgn0027705 FBgn0037311 FBgn0040681 FBgn0052464
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 13 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 14 ) FlyBase analysis  ( 5 ) DNA/RNA sequence record  ( 7 ) Stock list  ( 2 ) Website  ( 1 )
Recent research papers ( 5 )
	Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Wang et al., 2012, J. Immunol. 188(8): 3993--4000 The Drosophila protein mustard tailors the innate immune response activated by the immune deficiency pathway. [FBrf0217978] Carreira et al., 2011, BMC Dev. Biol. 11: 32 Genetic basis of wing morphogenesis in Drosophila: sexual dimorphism and non-allometric effects of shape variation. [FBrf0214273] Turner et al., 2011, PLoS Genet. 7(3): e1001336 Population-Based Resequencing of Experimentally Evolved Populations Reveals the Genetic Basis of Body Size Variation in Drosophila melanogaster. [FBrf0213327] Tuxworth et al., 2011, Hum. Mol. Genet. 20(10): 2037--2047 The Batten disease gene CLN3 is required for the response to oxidative stress. [FBrf0213533] Show all research papers ...