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Gene Dmel\mt:ATPase6

General Information
Symbol	Dmel\mt:ATPase6	Species	D. melanogaster
Name	mitochondrial ATPase subunit 6	Annotation symbol	CG34073
Feature type	protein_coding_gene	FlyBase ID	FBgn0013672
Gene Model Status	Current	Stock availability	None publicly available
Also Known As	ATP6, ATPase6, mtATP6
Genomic Location
Chromosome (arm)	dmel_mitochondrion_genome	Recombination map
Cytogenetic map		Sequence location	dmel_mitochondrion_genome:4,062..4,736 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mitochondrial ATPase subunit 6 is referred to in FlyBase by the symbol Dmel\mt:ATPase6 (CG34073, FBgn0013672). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: proton-transporting ATP synthase activity, rotational mechanism. There is experimental evidence that it is involved in the biological process: determination of adult lifespan; regulation of ATPase activity; locomotion; neuron homeostasis; muscle cell homeostasis; neurological system process. One allele is reported. The phenotypes of this allele are annotated with: mitochondrial crista; thoracico-abdominal ganglion; flight muscle; mitochondrial inner membrane; adult somatic muscle. It has one annotated transcript and one annotated polypeptide. Protein features are: ATPase, F0 complex, subunit A; ATPase, F0 complex, subunit A, active site. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of very low expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of mt:ATPase6. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of mt:ATPase6. Gene sequence location is dmel_mitochondrion_genome:4062..4736.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mt:ATPase6 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mt:ATPase6-RA FBtr0100867     675   224
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mt:ATPase6-PA   FBpp0100179   25.2   224   7.70       NP_008281
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • ATPase, F0 complex, subunit A (IPR000568) ATPase, F0 complex, subunit A, active site (IPR023011)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AF200828 AAF77230   AF200829 AAF77242   AJ400907 CAB91055   BP543160   BP548783   BP549477   BP552112   BP552145   BP552821   BP552840   BP552897   BP553260   BP557482   BP557576   BP558424   BP558542   BP558631   BP558879   BP558938   BP559038   BP559039   BP559281   BP559406   J01404 AAB59242   U37541 AAC47815
UniProtKB/Swiss-Prot	P00850
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
mitochondrion inferred from mutant phenotype (Celotto et al., 2006)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (Graveley et al., 2011) mE1_20_mRNA_expression_cluster_07
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013672
Alleles & Phenotypes
Summary of Allele Phenotypes
Other Phenotypes Allele bang sensitive mt:ATPase61 locomotor behavior defective mt:ATPase61 neuroanatomy defective mt:ATPase61 neurophysiology defective mt:ATPase61 paralytic mt:ATPase61 short lived mt:ATPase61 stress response defective mt:ATPase61 Phenotype manifest in Allele adult somatic muscle mt:ATPase61 flight muscle mt:ATPase61 mitochondrial crista mt:ATPase61 mitochondrial inner membrane mt:ATPase61 thoracico-abdominal ganglion mt:ATPase61
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of mt:ATPase6 Class Mutagen Stocks Known lesion mt:ATPase61 0 Yes
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mt:ATPase6 Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function
CV term Evidence References
proton-transporting ATP synthase activity, rotational mechanism inferred from mutant phenotype (Celotto et al., 2006)
Biological Process
CV term Evidence References
determination of adult lifespan inferred from mutant phenotype (Palladino et al., 2007, Celotto et al., 2006) locomotion inferred from mutant phenotype (Celotto et al., 2006) muscle cell homeostasis inferred from mutant phenotype (Palladino et al., 2007, Celotto et al., 2006) neurological system process inferred from mutant phenotype (Palladino et al., 2007) neuron homeostasis inferred from mutant phenotype (Celotto et al., 2006) regulation of ATPase activity inferred from mutant phenotype (Palladino et al., 2007)
Cellular Component
CV term Evidence References
mitochondrion inferred from mutant phenotype (Celotto et al., 2006)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
hydrogen-exporting ATPase activity, phosphorylative mechanism non-traceable author statement (FlyBase, 1992-)
Biological Process
CV term Evidence References
ATP synthesis coupled proton transport inferred from electronic annotation with InterPro:IPR000568 (FlyBase Curators et al., 2004-) mitochondrial ATP synthesis coupled proton transport inferred by curator from GO:0046933 (Celotto et al., 2006)
Cellular Component
CV term Evidence References
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) non-traceable author statement (Swiss-Prot Project Members, 1986.7.21) mitochondrion non-traceable author statement (FlyBase, 1992-) proton-transporting ATP synthase complex, coupling factor F(o) inferred from electronic annotation with InterPro:IPR000568 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	mt_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
mt:ATPase6 - CG31522 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mt:ATPase6 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0013672 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 192467
Orthologs
OrthoDB Orthologs (14) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6BG7TC Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG6P5Z52
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6BG7TC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25045   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26393   Camponotus floridanus Florida carpenter ant  Cflo\CFLO11993   Camponotus floridanus Florida carpenter ant  Cflo\CFLO11516   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12138   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12214   Solenopsis invicta Red fire ant  Sinv\SINV23057
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG6P5Z52)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\MTCE.12   Danio rerio Zebrafish  Drer\mt-atp6   Gallus gallus Domestic chicken  Ggal\ATP6   Mus musculus House mouse  Mmus\Gm10925   Mus musculus House mouse  Mmus\mt-Atp6   Rattus norvegicus Norway rat  Rnor\Mt-atp6   Homo sapiens Human  Hsap\ATP6
Human Orthologs (1)
Gene OMIM HGNC Hsap\ATP6
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 0 )
cDNA Clones ( 19 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	FGC019A01 FGM001G06 FGM101G01 FGM216H06 FGM217A12 FGM221A03 FGM221B01 FGM221D09 FGM223E02 FGM309E09 FGM310A11 FGM314H08 FGM315F02 FGM316B08 FGM317E11 FGM317H11 FGM318E04 FGM320A01 FGM320G05
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0013672 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 192467
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	New annotation (CG34073) in release 4.3 of the genome annotation. (FlyBase Genome Annotators, 2005) Amino acid substitutions found specifically in mt:ATPase6 are at sites not conserved among mammals, yeast or E.coli. These substitutions can be explained by neutral mutations and random genetic drift. (Kaneko et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	DDBJ / EMBL / GenBank • AAB59242 AAC47815 AAF77230 AAF77242 AF200828 AF200829 AJ400907 CAB91055 J01404 U37541 Entrez Gene - A searchable database of RefSeq genes. • 192467 UniProtKB/Swiss-Prot • P00850
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • ATPase, F0 complex, subunit A (IPR000568) ATPase, F0 complex, subunit A, active site (IPR023011)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0013672 DRSC - Results from RNAi screens. • FBgn0013672 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013672 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0013672 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 192467 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 192467 modMine - Data generated by the modENCODE project. • FBgn0013672
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	ATP6 (Frank et al., 2006, Palladino et al., 2007, Liu et al., 2012, Ballard, 2000, Aw et al., 2011, Celotto et al., 2006) atp6 (Torres et al., 2009, Stewart and Beckenbach, 2009) ATPase6 (Weinreich and Rand, 2000, Nachman, 1998, Calleja et al., 1993, Roberti et al., 2006, Celotto et al., 2006, Montooth et al., 2009) CG34073 (FlyBase Genome Annotators, 2005) mt:ATPase6 (Barnes et al., 2010) mtATP6 (Kotchey and Palladino, 2007, Korey, 2007)
Name Synonym	ATPase 6 (Ballard, 2000) ATPase 6 gene (Rand and Kann, 1996) mitochondrial ATP6 (Celotto et al., 2006) mitochondrial ATPase subunit 6
Secondary FlyBase IDs
	FBgn0002867
References ( 33 )
Generate a list of	All references relating to this gene ( 33 )
List References by type	Research paper  ( 22 ) Supplementary material  ( 1 ) Personal communication to FlyBase  ( 2 ) Abstract  ( 4 ) FlyBase analysis  ( 2 ) Conference report  ( 1 ) Protein sequence record  ( 1 )
Recent research papers ( 4 )
	Ilinsky, 2013, PLoS ONE 8(1): e54373 Coevolution of Drosophila melanogaster mtDNA and Wolbachia Genotypes. [FBrf0220609] Liu et al., 2012, Neurobiol. Disease 45(1): 362--368 Genetically encoded redox sensor identifies the role of ROS in degenerative and mitochondrial disease pathogenesis. [FBrf0216742] Aw et al., 2011, Mitochondrion 11(5): 756--763 Mitochondrial DNA variants in Drosophila melanogaster are expressed at the level of the organismal phenotype. [FBrf0214676] Celotto et al., 2011, PLoS ONE 6(10): e25823 Modes of Metabolic Compensation during Mitochondrial Disease Using the Drosophila Model of ATP6 Dysfunction. [FBrf0216386] Show all research papers ...