FlyBase Gene Report: Dmel\mt:CoII

General Information

Symbol

Dmel\mt:CoII

Species

D. melanogaster

Name

mitochondrial Cytochrome c oxidase subunit II

Annotation Symbol

CG34069

Feature Type

protein_coding_gene

FlyBase ID

FBgn0013675

Gene Model Status

Current

Stock Availability

2 publicly available

Enzyme Name (EC)

cytochrome-c oxidase (7.1.1.9)

Gene Summary

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. (UniProt, P00408)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

COII, COXII, Cox2, COX, CO II

Key Links

Genomic Location

Cytogenetic map

Sequence location

mitochondrion_genome:3,083..3,767 [+]

Recombination map

RefSeq locus

NC_024511 REGION:3083..3767

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI

UCSC

Ensembl

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables copper ion binding

inferred from electronic annotation with InterPro:IPR001505, InterPro:IPR002429

(InterPro Project Members, 2004-)

contributes_to cytochrome-c oxidase activity

inferred from sequence or structural similarity with UniProtKB:P00410

(Gene Ontology Curators, 2002-)

inferred from biological aspect of ancestor with PANTHER:PTN000527128

(GO Reference Genome Project, 2011-)

enables cytochrome-c oxidase activity

inferred from electronic annotation with InterPro:IPR002429, InterPro:IPR045187

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in ATP synthesis coupled electron transport

inferred from biological aspect of ancestor with PANTHER:PTN000527128

(GO Reference Genome Project, 2011-)

involved_in electron transport chain

inferred from electronic annotation with InterPro:IPR011759

(InterPro Project Members, 2004-)

involved_in mitochondrial electron transport, cytochrome c to oxygen

inferred from sequence or structural similarity with UniProtKB:P00410

(Gene Ontology Curators, 2002-)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in mitochondrial inner membrane

inferred from direct assay

(Brischigliaro et al., 2022)

part_of respiratory chain complex IV

inferred from direct assay

(Brischigliaro et al., 2022)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from electronic annotation with InterPro:IPR002429, InterPro:IPR011759, InterPro:IPR014222

(InterPro Project Members, 2004-)

part_of respiratory chain complex IV

inferred from sequence or structural similarity with UniProtKB:P00410

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX IV - CORE SUBUNITS

MITOCHONDRIAL COMPLEX IV - TESTIS-SPECIFIC VARIANT

MITOCHONDRIAL COMPLEX IV

Protein Family (UniProt)

Belongs to the cytochrome c oxidase subunit 2 family. (P00408)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

cytochrome-c oxidase activity

4 Fe(II)-[cytochrome c] + O2 + 8 H(+)(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H(+)(out) (7.1.1.9)

RHEA 11436:

Summaries

Gene Group (FlyBase)

MITOCHONDRIAL COMPLEX IV - CORE SUBUNITS -: Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. Eukaryotic COX is a multimeric enzyme formed by subunits of dual genetic origin. The three subunits forming the catalytic core of the enzyme (COX1, COX2 and COX3) are encoded by the mitochondrial DNA. (Adapted from PMID:17091399 and PMID:28870773.)
MITOCHONDRIAL COMPLEX IV - TESTIS-SPECIFIC VARIANT -: Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. (Adapted from PMID:17091399 and PMID:28870773.)
MITOCHONDRIAL COMPLEX IV -: Cytochrome c oxidase (COX) is the terminal complex (complex IV) of the electron transfer chain, embedded in the mitochondrial inner membrane. It catalyzes electron transfer from reduced cytochrome c to molecular oxygen in a process coupled to the transfer of protons across the inner membrane, thus contributing to the generation of the proton gradient that is used by ATP synthase to drive ATP synthesis. (Adapted from PMID:17091399 and PMID:28870773.)

Protein Function (UniProtKB)

(UniProt, P00408)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\mt:CoII for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P00408)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

mt:CoII-RA

FBtr0100863

685

228

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

mt:CoII-PA

FBpp0100177

26.2

228

4.72

P00408

NP_008279

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

(UniProt, P00408)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P00408

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mt:CoII using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in mitochondrial inner membrane

inferred from direct assay

(Brischigliaro et al., 2022)

part_of respiratory chain complex IV

inferred from direct assay

(Brischigliaro et al., 2022)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\mt:CoII in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\mt:CoII

View exonic expression by tissue for Dmel\mt:CoII

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

192470/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013675

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013675

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 1 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of mt:CoII

Transgenic constructs containing regulatory region of mt:CoII

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Sterility

Allele

male semi-fertile | temperature conditional

mt:CoII^G177S

male semi-sterile | temperature conditional

mt:CoII^G177S

Other Phenotypes

Allele

increased cell size | larval stage, with Scer\GAL4^unspecified

mt:CoII^TH04769.N

Phenotype manifest in

Allele

larval neuroblast, with Scer\GAL4^unspecified

mt:CoII^TH04769.N

mitochondrion | adult stage

mt:CoII^G177S

seminal vesicle | progressive | temperature conditional

mt:CoII^G177S

seminal vesicle | temperature conditional

mt:CoII^G177S

spermatid | progressive | temperature conditional

mt:CoII^G177S

spermatid | temperature conditional

mt:CoII^G177S

spermatid cyst | progressive | temperature conditional

mt:CoII^G177S

spermatid cyst | temperature conditional

mt:CoII^G177S

testis | progressive | temperature conditional

mt:CoII^G177S

testis | temperature conditional

mt:CoII^G177S

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (2)

Hsap\COX2

13 of 14

Yes

Hsap\MTCO2P12

10 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (1)

Rnor\COX2

13 of 14

Yes

Mus musculus (laboratory mouse) (1)

Mmus\COX2

12 of 14

Yes

Xenopus tropicalis (Western clawed frog) (1)

Xtro\COX2

10 of 13

Yes

Danio rerio (Zebrafish) (1)

Drer\COX2

13 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (1)

Cele\COX2

11 of 14

Yes

Anopheles gambiae (African malaria mosquito) (1)

Agam\COX2

10 of 12

Yes

Arabidopsis thaliana (thale-cress) (2)

Atha\AT2G07695

4 of 13

Yes

Atha\cox2

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\COX2

12 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\cox2

9 of 12

Yes

Spom\SPAC1F12.03c

1 of 12

Yes

Escherichia coli (enterobacterium) (1)

Ecol\cyoA

3 of 11

Yes

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:mt:CoII. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

MT-CO2; mitochondrially encoded cytochrome c oxidase II

13 of 14

516040

MTCO2P12; MT-CO2 pseudogene 12

10 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

mt:CoII - ATPsynγ

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - CG1416

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - COX4

experimental knowledge based, blue native page, peptide massfingerprinting, cosedimentation

(Brischigliaro et al., 2022, Rahman et al., 2014, Guruharsha et al., 2011)

mt:CoII - COX5A

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

mt:CoII - COX5B

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

mt:CoII - COX6B

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

mt:CoII - COX7A

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

mt:CoII - COX7AL2

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

mt:CoII - COX7B

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

mt:CoII - COX8

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

mt:CoII - Ipo9

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - KdelR

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - Mcad

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - Mec2

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - ND-MLRQ

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

mt:CoII - Rab1

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - Rab2

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - Rab5

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - Rap1

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - Rap2l

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - Rdh1

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - Rpt2

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - S6k

anti tag coimmunoprecipitation, Identification by mass spectrometry

(Vinayagam et al., 2016)

mt:CoII - SERCA

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - Tspo

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - UQCR-C2

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - cype

blue native page, peptide massfingerprinting, cosedimentation

(Brischigliaro et al., 2022, Rahman et al., 2014)

mt:CoII - l(1)G0320

experimental knowledge based

(Guruharsha et al., 2011)

mt:CoII - levy

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022, Rahman et al., 2014)

mt:CoII - mt:CoI

blue native page, peptide massfingerprinting, cosedimentation

(Brischigliaro et al., 2022, Rahman et al., 2014)

mt:CoII - mt:CoIII

cosedimentation, blue native page, peptide massfingerprinting

(Brischigliaro et al., 2022)

mt:CoII - wal

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Ssrp

suppressible

mt:CoII

(Lou et al., 2024)

External Data

Subunit Structure (UniProtKB)

(UniProt, P00408 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0013675

MIST (protein-protein) - An integrated Molecular Interaction Database

19893535

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

mt_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

mitochondrion_genome

Recombination map

Cytogenetic map

Sequence location

mitochondrion_genome:3,083..3,767 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (2)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

64853

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05726}attP40

VDRC

v109278

P{KK116296}VIE-260B

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0013675

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Murari et al., 2020, Matsushima et al., 2017)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CG34069) in release 4.3 of the genome annotation.

(FlyBase Genome Annotators, 2005)

Phylogeny of the hydei subgroup is inferred from 1,515 base pairs of mitochondrial DNA sequence of the cytochrome oxidase subunits I, II and III.

(Spicer and Pitnick, 1996)

During oogenesis RNA from mt:srRNA, mt:lrRNA, mt:ND2, mt:CoI, mt:CoII, mt:CoIII, mt:ND4, mt:ND5 and mt:Cyt-b shows fluctuations in RNA density after stage 9 in follicle and nurse cells.There is a correlation between the mtRNA level and the cell volume and/or the nuclear DNA content suggesting a global extra-mitochondrial, transcriptional control mechanism.

(Tourmente et al., 1990)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (32)

Reported As

Symbol Synonym

CG34069

(Murari et al., 2020, Çiçek et al., 2016, Choo et al., 2015, Keleman et al., 2009.8.5, Perkins et al., 2009, FlyBase Genome Annotators, 2005)

(Burnell et al., 1991)

CO II

(Salminen and Vale, 2020, Azou and Bregliano, 2001)

CO2

(Seligmann, 2012)

COI

(Gnainsky et al., 2021)

COII

(Anderson et al., 2022, Rodríguez et al., 2021, Zanini et al., 2018, Patel et al., 2016, Cooper et al., 2015, Bruni et al., 2012, Commar et al., 2012, van der Linde et al., 2010, Hatadani et al., 2009, Roberti et al., 2006, Ballard, 2000, Durando et al., 2000, O'Grady et al., 1998, Stenico and Nigro, 1998, Calleja et al., 1993)

COX

(Bouska et al., 2019, Walker and Benzer, 2004, Galloni, 2003, Maier et al., 2001)

COX2

(Brischigliaro et al., 2022, Loewen and Ganetzky, 2018, Bratic et al., 2016, Van Bortle et al., 2015)

COXII

(Camus et al., 2023, Huynh et al., 2020, Matsushima et al., 2017, Tsai et al., 2016, Baggio et al., 2014, Humphrey et al., 2012, Bratic et al., 2011, Jukes, 1990)

CcO subunit II

(Sohal et al., 2008)

Co-II

(Mossman et al., 2016)

CoII

(Vaught et al., 2020, Jaiswal et al., 2015, Yassin et al., 2010)

Cox2

(Lou et al., 2024, Tsakiri et al., 2019, Choo et al., 2015, Dowling et al., 2009, Dowling et al., 2007)

CytoCox

(Brookheart et al., 2017)

(Szuplewski and Terracol, 2001)

MT-CO2

(Guitart et al., 2013)

cox2

(Aradska et al., 2015, Stewart and Beckenbach, 2009, Torres et al., 2009)

dMtCOXII

(Murari et al., 2020)

mt COII

(Durando et al., 2000)

mt-CO2

(Peralta et al., 2012)

mt:COII

(Dowling and Wolff, 2023, Nozawa et al., 2023, Ågren et al., 2020)

mt:CoII

(Feng et al., 2024, Liu et al., 2024, Sen and Cox, 2022, Xie et al., 2021, Bahhir et al., 2019, Chen et al., 2019, Crofton et al., 2018, Lefebvre et al., 2016, Chartier et al., 2015, Iyer et al., 2013, Kwon et al., 2013, Peralta et al., 2012, Friedman et al., 2011, Wasbrough et al., 2010)

mt:Cox2

(Barry and Thummel, 2016)

mt:co2

(Clemente et al., 2022)

mt:coII

(Murari et al., 2022)

Name Synonyms

Cytochrome c oxidase I

(Brookheart et al., 2017)

Cytochrome c oxidase subunit II

(Iyer et al., 2013)

cytochrome c

(Caffrey and Cusanovich, 1994, Garber and Margoliash, 1994)

cytochrome c oxidase

(Galloni, 2003)

cytochrome c oxidase subunit II

(Jaspers et al., 2012, Sohal et al., 2008)

cytochrome oxidase II

(Patel et al., 2016, Durando et al., 2000)

mitochondrial Cytochrome c oxidase subunit II

(Gao et al., 2021)

Secondary FlyBase IDs

FBgn0002867

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 45 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

192470

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

NP_008279

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P00408

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P00408

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P00408

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

192470/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0013675

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0013675

FlyMine - An integrated database for Drosophila genomics

FBgn0013675

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG34069

MARRVEL_MODEL - MARRVEL (model organism gene)

192470

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0013675

DRSC - Results frm RNAi screens

FBgn0013675

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0013675

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

MIST (protein-protein) - An integrated Molecular Interaction Database

19893535

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (166)

The following external sites may use different assemblies or annotations than FlyBase.

NA

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