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Gene Dmel\mt:Cyt-b

General Information
Symbol	Dmel\mt:Cyt-b	Species	D. melanogaster
Name	mitochondrial Cytochrome b	Annotation symbol	CG34090
Feature type	protein_coding_gene	FlyBase ID	FBgn0013678
Gene Model Status	Current	Stock availability	None publicly available
Also Known As	Cytb, cyt b, Cyt-b
Genomic Location
Chromosome (arm)	dmel_mitochondrion_genome	Recombination map
Cytogenetic map		Sequence location	dmel_mitochondrion_genome:10,498..11,634 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mitochondrial Cytochrome b is referred to in FlyBase by the symbol Dmel\mt:Cyt-b (CG34090, FBgn0013678). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: ubiquinol-cytochrome-c reductase activity. There is experimental evidence that it is involved in the biological process: spermatogenesis. One allele is reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Cytochrome b/b6; Cytochrome b/b6, C-terminal; Cytochrome b/b6, N-terminal; Di-haem cytochrome, transmembrane. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of mt:Cyt-b. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of mt:Cyt-b. Gene sequence location is dmel_mitochondrion_genome:10498..11634.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mt:Cyt-b for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mt:Cyt-b-RA FBtr0100884     1137   378
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mt:Cyt-b-PA   FBpp0100186   43.2   378   8.67       NP_008288
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome b/b6, N-terminal (IPR005797) Cytochrome b/b6, C-terminal (IPR005798) Di-haem cytochrome, transmembrane (IPR016174) Cytochrome b/b6 (IPR016175) Cytochrome b/b6-like domain (IPR027387)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141615   AA433193   AA439488   AF200828 AAF77237   AF200829 AAF77249   AJ400907 CAB91062   BP541576   BP543292   BP543303   BP543402   BP543862   BP544560   BP547707   BP549747   BP556083   BP556194   BP556221   BP556833   BP558705   CO194036   EC081733   EC207864   M37275 AAA69714   U37541 AAC47822
UniProtKB/Swiss-Prot	P18935
UniProtKB/TrEMBL	Q9ME01
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013678
Alleles & Phenotypes
Summary of Allele Phenotypes
Sterility Allele male sterile | maternal effect mt:Cyt-bBrownsville Other Phenotypes Allele short lived | maternal effect mt:Cyt-bBrownsville Phenotype manifest in Allele spermatid | maternal effect mt:Cyt-bBrownsville testis | maternal effect mt:Cyt-bBrownsville
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of mt:Cyt-b Class Mutagen Stocks Known lesion mt:Cyt-bBrownsville natural population 0 Yes
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mt:Cyt-b Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
spermatogenesis inferred from mutant phenotype (Clancy et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
electron carrier activity inferred from electronic annotation with InterPro:IPR005797, InterPro:IPR005798 (FlyBase Curators et al., 2004-) oxidoreductase activity inferred from electronic annotation with InterPro:IPR005797, InterPro:IPR005798 (FlyBase Curators et al., 2004-) ubiquinol-cytochrome-c reductase activity non-traceable author statement (Swiss-Prot Project Members, 1990.11.1)
Biological Process
CV term Evidence References
respiratory electron transport chain inferred from electronic annotation with InterPro:IPR016174, InterPro:IPR016175 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR005797, InterPro:IPR005798, InterPro:IPR016174, InterPro:IPR016175 (FlyBase Curators et al., 2004-) mitochondrial respiratory chain complex III non-traceable author statement (Swiss-Prot Project Members, 1990.11.1)
Sequence Ontology: Class of Gene
	mt_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mt:Cyt-b allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0013678 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 192472
Orthologs
OrthoDB Orthologs (23) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6CZ9CB Arthropod inclusive ortholog search EOG6XD278 Metazoa inclusive ortholog search EOG6MD8T6
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6CZ9CB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG035105   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG033267   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26931   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26885   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12141   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL12216   Linepithema humile Argentine ant  Lhum\LH10522   Pogonomyrmex barbatus Red harvester ant  Pbar\PB10385   Pogonomyrmex barbatus Red harvester ant  Pbar\PB10364   Pogonomyrmex barbatus Red harvester ant  Pbar\PB10218   Pogonomyrmex barbatus Red harvester ant  Pbar\PB10646   Solenopsis invicta Red fire ant  Sinv\SINV16082   Solenopsis invicta Red fire ant  Sinv\SINV23060
Orthologs in non-Insect Arthropods (EOG6XD278)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\GSTK1   Ixodes scapularis Deer tick  Isca\ISCW016730
Orthologs in non-Arthropod Metazoa (EOG6MD8T6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\MTCE.21   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016012gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016080gn   Danio rerio Zebrafish  Drer\mt-cyb   Gallus gallus Domestic chicken  Ggal\CYTB   Mus musculus House mouse  Mmus\mt-Cytb   Rattus norvegicus Norway rat  Rnor\Mt-cyb   Homo sapiens Human  Hsap\CYB
Human Orthologs (1)
Gene OMIM HGNC Hsap\CYB
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 0 )
cDNA Clones ( 19 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	AA433193 CK01.92D.D11 CK01.96B.G4 CK02116 EC37305 FGC003B06 FGC019F10 FGC019G04 FGC020C08 FGC022G08 FGC026E08 FGH119H03 FGM103C04 FGM301C10 FGM301H09 FGM302A11 FGM305G07 FGM316F02 LD14072
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0013678 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 192472
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: mt:Cyt-b anon-EST:fe1B1 (Bayraktaroglu, 2000.11.2)
Additional comments
Other Comments
	New annotation (CG34090) in release 4.3 of the genome annotation. (FlyBase Genome Annotators, 2005) Steady state levels of mt:lrRNA RNA decrease as adult Drosophila age, and this change correlates with the shape of the life span curve. (Calleja et al., 1993) During oogenesis RNA from mt:srRNA, mt:lrRNA, mt:ND2, mt:CoI, mt:CoII, mt:CoIII, mt:ND4, mt:ND5 and mt:Cyt-b shows fluctuations in RNA density after stage 9 in follicle and nurse cells.There is a correlation between the mtRNA level and the cell volume and/or the nuclear DNA content suggesting a global extra-mitochondrial, transcriptional control mechanism. (Tourmente et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	DDBJ / EMBL / GenBank • AA433193 AAA69714 AAC47822 AAF77237 AAF77249 AF200828 AF200829 AJ400907 CAB91062 M37275 U37541 Entrez Gene - A searchable database of RefSeq genes. • 192472 UniProtKB/Swiss-Prot • P18935 UniProtKB/TrEMBL • Q9ME01
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Cytochrome b/b6, N-terminal (IPR005797) Cytochrome b/b6, C-terminal (IPR005798) Di-haem cytochrome, transmembrane (IPR016174) Cytochrome b/b6 (IPR016175) Cytochrome b/b6-like domain (IPR027387)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0013678 DRSC - Results from RNAi screens. • FBgn0013678 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013678 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0013678 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 192472 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 192472 modMine - Data generated by the modENCODE project. • FBgn0013678
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	anon-EST:fe1B1   CG34090 (FlyBase Genome Annotators, 2005) Cytb (Matsushima et al., 2004, Nachman, 1998, Rand and Kann, 1998, Calleja et al., 1993, Matsushima and Kaguni, 2007, Seligmann, 2012, Shim et al., 2009) cyt b (Azou and Bregliano, 2001, Roberti et al., 2006, Ballard, 2000, Bruni et al., 2012, Clancy et al., 2011) cytb (Schwarze et al., 1998, Torres et al., 2009, Stewart and Beckenbach, 2009) Cyt-b (Kula et al., 1995, Dowling et al., 2009) CytB (Dowling et al., 2007, Adan et al., 2008, Matsushima et al., 2010) Cyt b (Aw et al., 2011) CYTB (Peralta et al., 2012, Clancy et al., 2011) Cyt B (Iijima-Ando et al., 2009, Chang and Min, 2005) Cytob (Morel et al., 1999) mt:Cyt-b (Barnes et al., 2010) unnamed (Schmid and Tautz, 1997)
Name Synonym	anon-fast-evolving-1B1   Cytochrome-b (Rand and Kann, 1996) cytochrome b (Ballard, 2000, Iijima-Ando et al., 2009, Humphrey et al., 2012) mitochondrial Cytochrome b   mitochondrial cytochrome b (Clancy et al., 2011)
Secondary FlyBase IDs
	FBgn0002867 FBgn0025273
References ( 63 )
Generate a list of	All references relating to this gene ( 63 )
List References by type	Research paper  ( 36 ) Personal communication to FlyBase  ( 2 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) Protein sequence record  ( 1 ) DNA/RNA sequence record  ( 20 )
Recent research papers ( 6 )
	Bruni et al., 2012, Mitochondrion 12(5): 492--499 D-MTERF5 is a novel factor modulating transcription in Drosophila mitochondria. [FBrf0219394] Humphrey et al., 2012, Hum. Mol. Genet. 21(12): 2698--2712 Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila. [FBrf0218424] Peralta et al., 2012, J. Biol. Chem. 287(29): 24174--24185 Coiled Coil Domain-containing Protein 56 (CCDC56) Is a Novel Mitochondrial Protein Essential for Cytochrome c Oxidase Function. [FBrf0218928] Seligmann, 2012, J. Theor. Biol. 298: 51--76 An overlapping genetic code for frameshifted overlapping genes in Drosophila mitochondria: Antisense antitermination tRNAs UAR insert serine. [FBrf0217548] Aw et al., 2011, Mitochondrion 11(5): 756--763 Mitochondrial DNA variants in Drosophila melanogaster are expressed at the level of the organismal phenotype. [FBrf0214676] Clancy et al., 2011, Heredity 107(4): 374--376 Cytoplasmic male sterility in Drosophila melanogaster associated with a mitochondrial CYTB variant. [FBrf0215813] Show all research papers ...