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Gene Dmel\mt:ND4L

General Information
Symbol	Dmel\mt:ND4L	Species	D. melanogaster
Name	mitochondrial NADH-ubiquinone oxidoreductase chain 4L	Annotation symbol	CG34086
Feature type	protein_coding_gene	FlyBase ID	FBgn0013683
Gene Model Status	Current	Stock availability	None publicly available
Also Known As	ND4L
Genomic Location
Chromosome (arm)	dmel_mitochondrion_genome	Recombination map
Cytogenetic map		Sequence location	dmel_mitochondrion_genome:9,544..9,834 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mitochondrial NADH-ubiquinone oxidoreductase chain 4L is referred to in FlyBase by the symbol Dmel\mt:ND4L (CG34086, FBgn0013683). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: NADH dehydrogenase (ubiquinone) activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: ATP synthesis coupled electron transport. No alleles are reported. It has one annotated transcript and one annotated polypeptide. Protein features are: NADH-ubiquinone oxidoreductase chain 4L/K. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very low expression to a trough of no expression detected. Peak expression observed within 18-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: No FlyAtlas data available because no Affy2 ProbeSet aligns to an exon of mt:ND4L. Comments on Affy2 ProbeSet: No relevant information because no Affy2 ProbeSet aligns to an exon of mt:ND4L. Gene sequence location is dmel_mitochondrion_genome:9544..9834.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mt:ND4L for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mt:ND4L-RA FBtr0100880     291   96
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mt:ND4L-PA   FBpp0100184   11.4   96   6.49       NP_008286
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • NADH-ubiquinone oxidoreductase chain 4L/K (IPR001133)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AF200828 AAF77235   AF200829 AAF77247   AJ400907 CAB91060   M37275 AAA69712   U37541 AAC47820
UniProtKB/Swiss-Prot	P18934
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013683
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of mt:ND4L Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mt:ND4L Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
NADH dehydrogenase (ubiquinone) activity non-traceable author statement (FlyBase, 1992-, Swiss-Prot Project Members, 1990.11.1) oxidoreductase activity, acting on NAD(P)H inferred from electronic annotation with InterPro:IPR001133 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
ATP synthesis coupled electron transport inferred from electronic annotation with InterPro:IPR001133 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
mitochondrial respiratory chain complex I non-traceable author statement (FlyBase, 1992-) mitochondrion non-traceable author statement (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	mt_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mt:ND4L allele Gene References
External Data
Linkouts	InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 192477
Orthologs
OrthoDB Orthologs (6) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG6GN6SV
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG6GN6SV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Danio rerio Zebrafish  Drer\mt-nd4l   Gallus gallus Domestic chicken  Ggal\ND4L   Mus musculus House mouse  Mmus\ND4L   Mus musculus House mouse  Mmus\Gm10222   Rattus norvegicus Norway rat  Rnor\Mt-nd4l   Homo sapiens Human  Hsap\ND4L
Human Orthologs (1)
Gene OMIM HGNC Hsap\ND4L
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 0 )
cDNA Clones ( 0 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts	GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 192477
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	New annotation (CG34086) in release 4.3 of the genome annotation. (FlyBase Genome Annotators, 2005)
External Crossreferences & Linkouts
Sequence Crossreferences
	DDBJ / EMBL / GenBank • AAA69712 AAC47820 AAF77235 AAF77247 AF200828 AF200829 AJ400907 CAB91060 M37275 U37541 Entrez Gene - A searchable database of RefSeq genes. • 192477 UniProtKB/Swiss-Prot • P18934
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • NADH-ubiquinone oxidoreductase chain 4L/K (IPR001133)
Linkouts
	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013683 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0013683 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 192477 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 192477 modMine - Data generated by the modENCODE project. • FBgn0013683
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG34086 (FlyBase Genome Annotators, 2005) mt:ND4L   nad4L (Stewart and Beckenbach, 2009) ND4L (Roberti et al., 2006, Ballard, 2000, Bruni et al., 2012) nd4L (Torres et al., 2009) URF4L
Name Synonym	mitochondrial NADH-ubiquinone oxidoreductase chain 4L
Secondary FlyBase IDs
	FBgn0002867
References ( 14 )
Research paper	Bruni et al., 2012, Mitochondrion 12(5): 492--499 D-MTERF5 is a novel factor modulating transcription in Drosophila mitochondria. [FBrf0219394] Stewart and Beckenbach, 2009, Gene 445(1-2): 49--57 Characterization of mature mitochondrial transcripts in Drosophila, and the implications for the tRNA punctuation model in arthropods. [FBrf0208404] Torres et al., 2009, Nucleic Acids Res. 37(22): 7509--7518 Expression profiling of Drosophila mitochondrial genes via deep mRNA sequencing. [FBrf0209534] Roberti et al., 2006, Biochim. Biophys. Acta 1757(9-10): 1199--1206 MTERF3, the most conserved member of the mTERF-family, is a modular factor involved in mitochondrial protein synthesis. [FBrf0194696] Azou and Bregliano, 2001, Heredity 86(1): 110--116 I-R system of hybrid dysgenesis in Drosophila melanogaster: analysis of the mitochondrial DNA in reactive strains exhibiting different potentials for I factor transposition. [FBrf0135828] Ballard, 2000, J. Mol. Evol. 51(1): 48--63 Comparative genomics of mitochondrial DNA in members of the Drosophila melanogaster subgroup. [FBrf0128384] Moriyama and Powell, 1997, J. Mol. Evol. 45(4): 378--391 Synonymous substitution rates in Drosophila: mitochondrial versus nuclear genes. [FBrf0098855] Karlovsky and Fartmann, 1992, J. Mol. Evol. 34(3): 254--258 Genetic code and phylogenetic origin of oomycetous mitochondria. [FBrf0056634] Garesse, 1988, Genetics 118: 649--663 Drosophila melanogaster mitochondrial DNA: Gene organization and evolutionary considerations. [FBrf0048236]
Personal communication to FlyBase	FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]
FlyBase analysis	FlyBase Genome Annotators, 2005, Changes affecting gene model number or type in release 4.3 of the annotated D.melanogaster genome. Changes affecting gene model number or type in release 4.3 of the annotated D.melanogaster genome. [FBrf0188580] FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]
Protein sequence record	Swiss-Prot Project Members, 1990.11.1, UniProtKB: P18934 NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L (EC 1.6.5.3). [FBrf0123700]
DNA/RNA sequence record	Garcia et al., 2005.4.28, GenBank/EMBL/DDBJ: DQ021479 Drosophila willistoni NADH dehydrogenase subunit 4 and NADH dehydrogenase subunit 4L genes, partial cds; mitochondrial. [FBrf0197301]