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General Information
Symbol
Dmel\phyl
Species
D. melanogaster
Name
phyllopod
Annotation Symbol
CG10108
Feature Type
FlyBase ID
FBgn0013725
Gene Model Status
Stock Availability
Gene Snapshot
Also Known As

phy1, Su(Raf)2C

Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:14,427,336..14,432,337 [-]
Recombination map

2-71

RefSeq locus
NT_033778 REGION:14427336..14432337
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (18 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from physical interaction with UniProtKB:P21461
(assigned by UniProt )
inferred from physical interaction with UniProtKB:Q95RJ9
(assigned by UniProt )
Terms Based on Predictions or Assertions (0 terms)
Biological Process (13 terms)
Terms Based on Experimental Evidence (13 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from expression pattern
inferred from expression pattern
inferred from genetic interaction with FLYBASE:sina; FB:FBgn0003410
inferred from mutant phenotype
(assigned by CACAO )
inferred from genetic interaction with FLYBASE:phyl; FB:FBgn0013725
inferred from genetic interaction with FLYBASE:Raf; FB:FBgn0003079
inferred from mutant phenotype
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Pathway (FlyBase)
    Negative Regulators of Wnt-TCF Signaling Pathway -
    Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
    Sevenless Signaling Pathway Core Components -
    The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of Sevenless receptor tyrosine kinase, which acts via the canonical Ras/Raf/MAP kinase cascade to promote the expression of lz and pros. sev, expressed in presumptive R7 cells, is activated by binding to Bride of Sevenless (boss), a seven-transmembrane protein expressed in R8 cells. (Adapted from FBrf0127283 and FBrf0221727).
    Negative Regulators of Notch Signaling Pathway -
    The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Negative regulators of the pathway down-regulate the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).
    EGFR Signaling Pathway Core Components -
    The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
    Protein Function (UniProtKB)
    Essential adapter component of E3 ubiquitin ligase complexes; involved in R7 photoreceptor cell differentiation, embryonic nervous system, external sensory organ development and specification of particular muscles. E3 ubiquitin ligase complexes mediate ubiquitination and subsequent proteasomal degradation of target proteins. Required for specification of R7 photoreceptor cell fate in the eye by participating in the ubiquitination and subsequent proteasomal degradation of Tramtrack (ttk), a general inhibitor of photoreceptor differentiation. Acts downstream of Notch signaling to specify the fate of the SOP (sensory organ precursor) cells and their progeny, probably via the sina-mediated proteasomal degradation of ttk. Its restricted pattern of expression, upon Notch and Ras signaling pathways, suggests that it acts as a key determinant in E3 complexes to trigger protein proteolysis in appropriate cells.
    (UniProt, Q27934)
    Summary (Interactive Fly)

    a target of EGFR signalling in the eye - protein degradation cofactor - involved in a negative cross talk between RTK and Notch/Wg pathways - Post‐transcriptional downregulation of Notch and Wg signalling by Phyl allows fine‐tuning of the signal and creates a delicate balance between active signalling of Notch/Wg pathways and their degradation by the lysosomal pathway

    Gene Model and Products
    Number of Transcripts
    1
    Number of Unique Polypeptides
    1

    Please see the JBrowse view of Dmel\phyl for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model

    Gene model reviewed during 5.50

    Sequence Ontology: Class of Gene
    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    Assoc. CDS (aa)
    FBtr0087516
    1839
    400
    Additional Transcript Data and Comments
    Reported size (kB)

    1.8 (northern blot)

    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Name
    FlyBase ID
    Predicted MW (kDa)
    Length (aa)
    Theoretical pI
    RefSeq ID
    GenBank
    FBpp0086645
    44.8
    400
    8.49
    Polypeptides with Identical Sequences

    There is only one protein coding transcript and one polypeptide associated with this gene

    Additional Polypeptide Data and Comments
    Reported size (kDa)

    400 (aa); 45 (kD predicted)

    Comments
    External Data
    Subunit Structure (UniProtKB)

    Component of some E3 complex at least composed of sina, ebi and phyl, required for the degradation of ttk.

    (UniProt, Q27934)
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\phyl using the Feature Mapper tool.

    External Data
    Crossreferences
    Linkouts
    Expression Data
    Expression Summary Ribbons
    Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
    For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
    Transcript Expression
    in situ
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    ventral ectoderm anlage

    Comment: anlage in statu nascendi

    antennal anlage in statu nascendi

    Comment: reported as procephalic ectoderm anlage in statu nascendi

    dorsal head epidermis anlage in statu nascendi

    Comment: reported as procephalic ectoderm anlage in statu nascendi

    visual anlage in statu nascendi

    Comment: reported as procephalic ectoderm anlage in statu nascendi

    antennal anlage

    Comment: reported as procephalic ectoderm anlage

    central brain anlage

    Comment: reported as procephalic ectoderm anlage

    dorsal head epidermis anlage

    Comment: reported as procephalic ectoderm anlage

    visual anlage

    Comment: reported as procephalic ectoderm anlage

    antennal primordium

    Comment: reported as procephalic ectoderm primordium

    central brain primordium

    Comment: reported as procephalic ectoderm primordium

    visual primordium

    Comment: reported as procephalic ectoderm primordium

    dorsal head epidermis primordium

    Comment: reported as procephalic ectoderm primordium

    lateral head epidermis primordium

    Comment: reported as procephalic ectoderm primordium

    ventral head epidermis primordium

    Comment: reported as procephalic ectoderm primordium

    Additional Descriptive Data

    phyl transcripts are expressed in the eye imaginal disc. They are first expressed in a periodic group of cells in the morphogenetic furrow and are later expressed in a dynamic pattern in a subset of photoreceptor cells. The staining intensity is reduced immediately posterior to the furrow and becomes more intense again approximately six rows behind the furrow. Perinuclear staining becomes evident in photoreceptor cells R1 and R6 in row 6. By row 7, perinuclear staining is evident in R7. Staining remains strong in R1, R6, and R7 through row 9 and then diminishes. None of the other photoreceptor cells or the cone cells express phyl.

    phyl transcripts are expressed in a highly dynamic pattern in the eye imaginal disc. Within the morphogenetic furrow, they are detected in regularly spaced clusters of about 12 cells. Posterior to the furrow, they are mostly confined to a thin stripe approximately spanning the region between ommatidial columns 4-8. Within this stripe, phyl transcripts appear in clusters that appear to consist of three cells, presumed to be the precursors of photoreceptor cells R1, R6, and R7. No transcripts are detected in cone cell precursors.

    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    inferred from direct assay
    inferred from direct assay
    inferred from direct assay
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    GBrowse - Visual display of RNA-Seq signals

    View Dmel\phyl in GBrowse 2
    RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Images
    FlyExpress - Embryonic expression images (BDGP data)
    • Stages(s) 4-6
    • Stages(s) 7-8
    • Stages(s) 9-10
    • Stages(s) 11-12
    Alleles, Insertions, and Transgenic Constructs
    Classical and Insertion Alleles ( 22 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 14 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of phyl
    Transgenic constructs containing regulatory region of phyl
    Deletions and Duplications ( 11 )
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Lethality
    Allele
    Other Phenotypes
    Allele
    Phenotype manifest in
    Allele
    adult abdominal segment 3 & chaeta (with phyl1)
    adult abdominal segment 3 & chaeta (with phyl2)
    adult abdominal segment 3 & chaeta (with phyl4)
    adult abdominal segment 3 & microchaeta (with phyl1)
    adult abdominal segment 3 & microchaeta (with phyl2)
    adult abdominal segment 3 & microchaeta (with phyl4)
    adult abdominal segment 3 & tormogen cell | supernumerary (with phyl1)
    adult abdominal segment 3 & tormogen cell | supernumerary (with phyl2)
    adult abdominal segment 3 & tormogen cell | supernumerary (with phyl4)
    adult abdominal segment 3 & trichogen cell | supernumerary (with phyl1)
    adult abdominal segment 3 & trichogen cell | supernumerary (with phyl2)
    adult abdominal segment 3 & trichogen cell | supernumerary (with phyl4)
    adult abdominal segment 4 & chaeta (with phyl1)
    adult abdominal segment 4 & chaeta (with phyl2)
    adult abdominal segment 4 & chaeta (with phyl4)
    adult abdominal segment 4 & microchaeta (with phyl1)
    adult abdominal segment 4 & microchaeta (with phyl2)
    adult abdominal segment 4 & microchaeta (with phyl4)
    adult abdominal segment 4 & tormogen cell | supernumerary (with phyl1)
    adult abdominal segment 4 & tormogen cell | supernumerary (with phyl2)
    adult abdominal segment 4 & tormogen cell | supernumerary (with phyl4)
    adult abdominal segment 4 & trichogen cell | supernumerary (with phyl1)
    adult abdominal segment 4 & trichogen cell | supernumerary (with phyl2)
    adult abdominal segment 4 & trichogen cell | supernumerary (with phyl4)
    chordotonal organ & neuron
    external sensory organ & neuron
    macrochaeta & scutum
    mesothoracic tergum & chaeta (with phyl1)
    mesothoracic tergum & chaeta (with phyl2)
    mesothoracic tergum & chaeta (with phyl4)
    mesothoracic tergum & microchaeta (with phyl1)
    mesothoracic tergum & microchaeta (with phyl2)
    mesothoracic tergum & microchaeta (with phyl4)
    mesothoracic tergum & microchaeta | ectopic, with Scer\GAL4Eq
    mesothoracic tergum & tormogen cell | supernumerary (with phyl1)
    mesothoracic tergum & tormogen cell | supernumerary (with phyl2)
    mesothoracic tergum & tormogen cell | supernumerary (with phyl4)
    mesothoracic tergum & trichogen cell | supernumerary (with phyl1)
    mesothoracic tergum & trichogen cell | supernumerary (with phyl2)
    mesothoracic tergum & trichogen cell | supernumerary (with phyl4)
    microchaeta & scutum
    wing vein L3 & chaeta | ectopic, with Scer\GAL4dpp.blk1
    Orthologs
    Human Orthologs (via DIOPT v8.0)
    Homo sapiens (Human) (1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Alignment
    Complementation?
    Transgene?
    1 of 15
    Yes
    Yes
    Model Organism Orthologs (via DIOPT v8.0)
    Mus musculus (laboratory mouse) (0)
    No records found.
    Rattus norvegicus (Norway rat) (0)
    No records found.
    Xenopus tropicalis (Western clawed frog) (0)
    No records found.
    Danio rerio (Zebrafish) (0)
    No records found.
    Caenorhabditis elegans (Nematode, roundworm) (0)
    No records found.
    Arabidopsis thaliana (thale-cress) (0)
    No records found.
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    No records found.
    Schizosaccharomyces pombe (Fission yeast) (0)
    No records found.
    Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190CL0 )
    Organism
    Common Name
    Gene
    AAA Syntenic Ortholog
    Multiple Dmel Genes in this Orthologous Group
    Drosophila suzukii
    Spotted wing Drosophila
    Drosophila simulans
    Drosophila sechellia
    Drosophila erecta
    Drosophila yakuba
    Drosophila ananassae
    Drosophila pseudoobscura pseudoobscura
    Drosophila persimilis
    Drosophila willistoni
    Drosophila virilis
    Drosophila mojavensis
    Drosophila grimshawi
    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505OQ )
    Organism
    Common Name
    Gene
    Multiple Dmel Genes in this Orthologous Group
    Musca domestica
    House fly
    Glossina morsitans
    Tsetse fly
    Lucilia cuprina
    Australian sheep blowfly
    Mayetiola destructor
    Hessian fly
    Aedes aegypti
    Yellow fever mosquito
    Anopheles darlingi
    American malaria mosquito
    Anopheles gambiae
    Malaria mosquito
    Culex quinquefasciatus
    Southern house mosquito
    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
    No non-Dipteran orthologies identified
    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
    No non-Insect Arthropod orthologies identified
    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
    No non-Arthropod Metazoa orthologies identified
    Paralogs
    Paralogs (via DIOPT v8.0)
    Drosophila melanogaster (Fruit fly) (0)
    No records found.
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Model Summary Ribbon
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement

      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Subunit Structure (UniProtKB)
      Component of some E3 complex at least composed of sina, ebi and phyl, required for the degradation of ttk.
      (UniProt, Q27934 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Negative Regulators of Wnt-TCF Signaling Pathway -
      Negative regulators of Wnt-TCF (canonical Wnt) signaling down-regulate the pathway, resulting in the attenuation of transcriptional regulation mediated by β-catenin (arm).
      Sevenless Signaling Pathway Core Components -
      The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of Sevenless receptor tyrosine kinase, which acts via the canonical Ras/Raf/MAP kinase cascade to promote the expression of lz and pros. sev, expressed in presumptive R7 cells, is activated by binding to Bride of Sevenless (boss), a seven-transmembrane protein expressed in R8 cells. (Adapted from FBrf0127283 and FBrf0221727).
      Negative Regulators of Notch Signaling Pathway -
      The Notch receptor signaling pathway is activated by the binding of the transmembrane receptor Notch (N) to transmembrane ligands, Dl or Ser, presented on adjacent cells. This results in the proteolytic cleavage of N, releasing the intracellular domain (NICD). NICD translocates into the nucleus, interacting with Su(H) and mam to form a transcription complex, which up-regulates transcription of Notch-responsive genes. Negative regulators of the pathway down-regulate the signal from the sending cell or the response in the receiving cell. (Adapted from FBrf0225731 and FBrf0192604).
      EGFR Signaling Pathway Core Components -
      The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
      Metabolic Pathways
      External Data
      Linkouts
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      2R
      Recombination map

      2-71

      Cytogenetic map
      Sequence location
      2R:14,427,336..14,432,337 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      51A2-51A2
      Limits computationally determined from genome sequence between P{PZ}Tfb106949&P{PZ}l(2)0356303563 and P{lacW}l(2)k16805k16805
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      51A1-51A2
      51A1-51A2
      (determined by in situ hybridisation)
      Mapped by a combination of recombination and complementation analysis.
      Experimentally Determined Recombination Data
      Left of (cM)
      Right of (cM)
      Notes

      17 recombinants were detected between phyl and Tfb1, out of 29,738 flies screened.

      Stocks and Reagents
      Stocks (10)
      Genomic Clones (25)
      cDNA Clones (42)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of
      Additional comments
      Other Comments

      Cells mutant for phyl are competent for internalizing Dl and wg but are restricted in subsequent trafficking steps cuasing an accumulation of Dl and wg in Hrs-positive endosomes.

      phyl specifically helps traffic N and wg pathways components within early endocytic vesicles, thereby controlling the amount of processed signal available for causing a transcriptional response within the nucleus.

      phyl is required for the formation of sensory organ precursor cells (SOPs) and cell fate specification of SOP progeny.

      Genetic studies suggest that 14-3-3ε functions in multiple receptor tyrosine kinase pathways, acting downstream or parallel to phl, but upstream of aop and phyl, two nuclear factors involved in Ras85D signalling.

      Down-regulation of ttk protein expression in developing photoreceptor cells requires the presence of the phyl and sina proteins.

      Expression of the ttk TTK88 protein isoform represses neuronal fate determination in the developing eye. phyl protein acts to antagonise this repression by a mechanism that requires sina protein.

      Identified in a genetic screen for modifiers of the phl::tor12D.sev rough eye mutant phenotype.

      phyl interacts with another nuclear factor, sina, to form a complex and both factors are involved in upregulating transcription of pros in the eye.

      phyl encodes a novel protein autonomously required for fate determination of photoreceptors R1, R6 and R7. Genetic data suggest phyl acts downstream of Ras85D, phl and aop to promote neuronal differentiation in R1, R6 and R7. Ectopic expression of phyl in the cone cell precursors mimics the effect of ectopic activation of Ras85D suggesting that phyl expression is regulated by Ras85D. phyl expression is also required for embryonic nervous system and sensory bristle development.

      Required for photoreceptor differentiation, acting downstream of Ras.

      The phyl gene regulates the fates of a subset of cells in the developing eye and represents a possible target gene of the Raf pathway. Within photoreceptors R1, R6 and R7, phyl expression mimics the activation of the Raf pathway in its ability to induce photoreceptor rather than cone cell development. The transformation of cone cells into R7 cells in response to Raf activation is accompanied by and dependent upon ectopic phyl expression.

      A screen to identify mutations affecting the Ras85D signalling pathway identified alleles of phl, Dsor1, rl, aop, βggt-I, mts, ksr and phyl.

      phyl might be one of the target genes acted on by the Jra and pnt gene products in the induction of photoreceptor R7 development in the eye.

      Origin and Etymology
      Discoverer
      Etymology

      The name "phyl" ("phyllopod") was inspired by the phenotype of homozygous phyl clones in the eye. In such clones five photoreceptors and 5-6 cone cells are present, resembling the compound eye of some phyllopods (class Crustacea).

      The phyl mutants cause an ommatidial composition similar, but not identical to that of some phyllopod crustacea, such as Leptodora, hence the gene name.

      Identification
      External Crossreferences and Linkouts ( 33 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (10)
      Reported As
      Secondary FlyBase IDs
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (129)