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Gene Dmel\alien

General Information
Symbol	Dmel\alien	Species	D. melanogaster
Name	alien	Annotation symbol	CG9556
Feature type	protein_coding_gene	FlyBase ID	FBgn0013746
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	CSN2, Dch2
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	29F7-29F7	Sequence location	2L:8,993,818..8,997,379 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene alien is referred to in FlyBase by the symbol Dmel\alien (CG9556, FBgn0013746). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; nuclear hormone receptor binding; ligand-dependent nuclear receptor binding; protein homodimerization activity; transcription corepressor activity. There is experimental evidence that it is involved in the biological process: protein stabilization; mitotic G2 DNA damage checkpoint; negative regulation of transcription, DNA-dependent; neurogenesis; phagocytosis, engulfment. 3 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: PCI/PINT associated module; Proteasome component (PCI) domain; Tetratricopeptide-like helical; Winged helix-turn-helix transcription repressor DNA-binding domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, larval Malpighian tubules, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638830_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of alien. Gene sequence location is 2L:8993818..8997379.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Polypeptides alien-PE Controlled Vocabulary Terms regulation of cell cycle Transcripts alien-RE
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 29F7-29F7   Limits computationally determined from genome sequence between P{lacW}l(2)k04003k04003 and P{PZ}tai01351
Experimentally Determined Cytological Location
Cytogenetic map Notes References 29F-30A     (Paululat, 1996.5.8) 29F-30A   (determined by in situ hybridisation)   (Goubeaud et al., 1996)
Experimentally Determined Recombination Data
Location	2- (Paululat, 1996.5.8)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\alien for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Antisense UTR: 3' UTR is antisense to CG17906 on opposite strand. Gene model reviewed during 5.49 Gene model reviewed during 5.44 Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) alien-RA FBtr0079780  NM_164843   1508   444 alien-RB FBtr0079781  NM_078793   2321   444 alien-RD FBtr0339550  NM_001273347   3172   444 alien-RE FBtr0343095     1574   444
Additional Transcript Data & Comments
Reported size (kB)	1.486 (longest cDNA) (Freilich et al., 1999) 1.4 (northern blot) (Goubeaud et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein alien-PA   FBpp0079381   51.5   444   5.28     NP_723438   AAN10685 alien-PB   FBpp0089195   51.5   444   5.28     NP_523517   AAF52736 alien-PD   FBpp0308633   51.5   444   5.28     NP_001260276   AGB92812 alien-PE   FBpp0309805   51.5   444   5.28
Additional Polypeptide Data & Comments
Reported size (kDa)	444 (aa) (Freilich et al., 1999) 360 (aa); 42 (kD predicted) (Goubeaud et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Proteasome component (PCI) domain (IPR000717) PCI/PINT associated module (IPR013143) Winged helix-turn-helix DNA-binding domain (IPR011991) Tetratricopeptide-like helical (IPR011990)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263724   AA391270   AA440068   AA440125   AA538664   AA816744   AA979379   AE014134 AAF52736   AE014134 AAN10685   AF129079 AAD28604   AE014134 AGB92812   AI134843   AI239198   AI388935   AI511751   AI518333   AI534373   AI546117   AI546587   AW942135   AW944540   AY069836 AAL39981   AY118505 AAM49874   BF490861   BF494680   BF505016   BG637144   BG639182   BI171098   BI236017   BI240822   BI352824   BI358070   BI482677   BI632890   BX010303   CO317950   CO337338   EC227110   EC263367   EL879723   EL879847   EL879976   EL879977   EL880111   GH943728   GH946543   GH947119   GH947573   GH947839   GH948482   GH948613   GH951357   GH951525   GH952266   GH956227   GH957703   GH959729   GH960094   GH960397   GH960513   GH962583   GH962625   GH964701   GH968815   GH970602   GH974186   GH978629   GH979805   GH980643   GH981424   GH981517   U57758 AAB49932
UniProtKB/Swiss-Prot	Q94899
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012)
Additional Descriptive Data
	alien transcripts are detected in embryos on northern blots. The levels decrease dramatically during embryogenesis. High levels of alien transcripts are detected by in situ hybridization during oogenesis. (Goubeaud et al., 1996)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval abdominal 1 intrasegmental apodeme 2 -- embryonic/larval abdominal 7 intrasegmental apodeme 2   (Goubeaud et al., 1996) apodeme of pharynx   (Goubeaud et al., 1996) embryonic/larval abdominal 1 intersegmental apodeme -- embryonic/larval abdominal 7 intersegmental apodeme   (Goubeaud et al., 1996) embryonic/larval intersegmental apodeme   (Goubeaud et al., 1996) embryonic/larval abdominal 1 intrasegmental apodeme 1 -- embryonic/larval abdominal 7 intrasegmental apodeme 1   (Goubeaud et al., 1996) embryonic/larval intrasegmental apodeme   (Goubeaud et al., 1996) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
repressor ecdysone receptor complex inferred from physical interaction with EcR (Dressel et al., 1999) signalosome inferred from physical interaction with CSN5 (Freilich et al., 1999) inferred from physical interaction with CSN7 (Freilich et al., 1999)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, larval Malpighian tubules, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    639.625 Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules    718.6 Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye    525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary    609.4 Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (639.625) Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules  (718.6) Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye  525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary  (609.4) Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    639.625 Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules    718.6 Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye    525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary    609.4 Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    639.625 Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules    718.6 Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye    525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary    609.4 Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    639.625 Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules    718.6 Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye    525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary    609.4 Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  639.625 Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules  718.6 Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye  525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary  609.4 Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    639.625 Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules    718.6 Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye    525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary    609.4 Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    639.625 Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules    718.6 Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye    525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary    609.4 Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    375.8   NA  Eye    525.875   NA  Brain    436.3   639.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    379.5   NA  Crop    358.2   392.5  Midgut    345.7   402.3  Hindgut    323.5   718.6  Malpighian Tubules    346.5   476.9  Fat Body    252.7   407.1  Salivary Gland    282   NA  Heart    265.175   497.55  Trachea    NA   NA  VirginFemale Spermatheca    461.8   NA  InseminatedFemale Spermatheca    432.7   NA  Ovary    609.4   NA  Testis    263.6   NA  Male Accessory Gland    362.4   450.875  Carcass    228.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    24 central nervous system, pupae P8    18 head, virgin 1-day female    14 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    10 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    11 carcass, larvae L3 wandering    24 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    38 ovary, mated 4-day female    38 testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  26 central nervous system, larvae L3    24 central nervous system, pupae P8    18 head, virgin 1-day female    14 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male  (28) salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    10 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    11 carcass, larvae L3 wandering    24 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female  (38) ovary, mated 4-day female  (38) testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    24 central nervous system, pupae P8    18 head, virgin 1-day female    14 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    10 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    11 carcass, larvae L3 wandering    24 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    38 ovary, mated 4-day female    38 testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    24 central nervous system, pupae P8    18 head, virgin 1-day female    14 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    10 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    11 carcass, larvae L3 wandering    24 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    38 ovary, mated 4-day female    38 testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    24 central nervous system, pupae P8    18 head, virgin 1-day female    14 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    10 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    11 carcass, larvae L3 wandering    24 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    38 ovary, mated 4-day female    38 testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  26 central nervous system, larvae L3    24 central nervous system, pupae P8    18 head, virgin 1-day female    14 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male  28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    10 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    11 carcass, larvae L3 wandering    24 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female  (38) ovary, mated 4-day female  (38) testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    24 central nervous system, pupae P8    18 head, virgin 1-day female    14 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    10 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    11 carcass, larvae L3 wandering    24 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    38 ovary, mated 4-day female    38 testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    26 central nervous system, larvae L3    24 central nervous system, pupae P8    18 head, virgin 1-day female    14 head, virgin 4-day female    11 head, virgin 20-day female    11 head, mated 1-day female    10 head, mated 4-day female    11 head, mated 20-day female    11 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male    28 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    10 digestive system, larvae L3 wandering    20 digestive system, 1-day adult    13 digestive system, 4-day adult    13 digestive system, 20-day adult    10 fat body, larvae L3 wandering    6 fat body, white prepupae    13 fat body, pupae P8    11 carcass, larvae L3 wandering    24 carcass, 1-day adult    9 carcass, 4-day adult    9 carcass, 20-day adult    9 ovary, virgin 4-day female    38 ovary, mated 4-day female    38 testis, mated 4-day male    17 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    57 embryo 04-06hr    45 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    22 embryo 12-14hr    23 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    9 embryo 20-22hr    20 embryo 22-24hr    22 larva L1    11 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    26 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day    29 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (57) embryo 04-06hr  (45) embryo 06-08hr    25 embryo 08-10hr  (28) embryo 10-12hr    22 embryo 12-14hr    23 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    9 embryo 20-22hr    20 embryo 22-24hr    22 larva L1    11 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9  26 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr  26 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day  (29) adult female 30day  (27) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    57 embryo 04-06hr    45 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    22 embryo 12-14hr    23 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    9 embryo 20-22hr    20 embryo 22-24hr    22 larva L1    11 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    26 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day    29 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    57 embryo 04-06hr    45 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    22 embryo 12-14hr    23 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    9 embryo 20-22hr    20 embryo 22-24hr    22 larva L1    11 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    26 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day    29 adult female 30day    27 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    57 embryo 04-06hr    45 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    22 embryo 12-14hr    23 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    9 embryo 20-22hr    20 embryo 22-24hr    22 larva L1    11 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    26 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day    29 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35) embryo 02-04hr  (57) embryo 04-06hr  (45) embryo 06-08hr    25 embryo 08-10hr  28 embryo 10-12hr    22 embryo 12-14hr    23 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    9 embryo 20-22hr    20 embryo 22-24hr    22 larva L1    11 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9  26 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr  26 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day  29 adult female 30day  27 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    57 embryo 04-06hr    45 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    22 embryo 12-14hr    23 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    9 embryo 20-22hr    20 embryo 22-24hr    22 larva L1    11 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    26 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day    29 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35 embryo 02-04hr    57 embryo 04-06hr    45 embryo 06-08hr    25 embryo 08-10hr    28 embryo 10-12hr    22 embryo 12-14hr    23 embryo 14-16hr    15 embryo 16-18hr    16 embryo 18-20hr    9 embryo 20-22hr    20 embryo 22-24hr    22 larva L1    11 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    18 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    26 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    26 pupae 2d postWPP    19 pupae 3d postWPP    13 pupae 4d postWPP    7 adult male 01day    14 adult male 05day    14 adult male 30day    13 adult female 01day    14 adult female 05day    29 adult female 30day    27 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    49 Schneider line 2 Sg4    33 embryonic 1182-4H    26 embryonic GM2    23 embryonic Kc167    21 embryonic S1    40 embryonic S3    34 leg disc CME L1    31 wing disc CME-W2    55 wing disc ML-DmD8    27 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    61 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    90 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    31 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    26 ovary fGS/OSS    33 ovary OSC    39 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (49) Schneider line 2 Sg4  (33) embryonic 1182-4H  26 embryonic GM2    23 embryonic Kc167    21 embryonic S1  (40) embryonic S3  (34) leg disc CME L1  (31) wing disc CME-W2  (55) wing disc ML-DmD8  (27) wing disc ML-DmD9  (38) wing disc ML-DmD16-c3  (45) wing disc ML-DmD21  (61) wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (90) eye-antennal disc ML-DmD11  (39) antennal disc ML-DmD20-c5  (31) mixed discs ML-DmD4-c1  (32) CNS ML-DmBG1-c1  (41) CNS ML-DmBG2-c2  (31) tumorous blood cells mbn2  26 ovary fGS/OSS  (33) ovary OSC  (39) ovary OSS  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    49 Schneider line 2 Sg4    33 embryonic 1182-4H    26 embryonic GM2    23 embryonic Kc167    21 embryonic S1    40 embryonic S3    34 leg disc CME L1    31 wing disc CME-W2    55 wing disc ML-DmD8    27 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    61 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    90 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    31 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    26 ovary fGS/OSS    33 ovary OSC    39 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    49 Schneider line 2 Sg4    33 embryonic 1182-4H    26 embryonic GM2    23 embryonic Kc167    21 embryonic S1    40 embryonic S3    34 leg disc CME L1    31 wing disc CME-W2    55 wing disc ML-DmD8    27 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    61 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    90 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    31 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    26 ovary fGS/OSS    33 ovary OSC    39 ovary OSS    26 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    49 Schneider line 2 Sg4    33 embryonic 1182-4H    26 embryonic GM2    23 embryonic Kc167    21 embryonic S1    40 embryonic S3    34 leg disc CME L1    31 wing disc CME-W2    55 wing disc ML-DmD8    27 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    61 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    90 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    31 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    26 ovary fGS/OSS    33 ovary OSC    39 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (49) Schneider line 2 Sg4  (33) embryonic 1182-4H  26 embryonic GM2    23 embryonic Kc167    21 embryonic S1  (40) embryonic S3  (34) leg disc CME L1  31 wing disc CME-W2  (55) wing disc ML-DmD8  27 wing disc ML-DmD9  (38) wing disc ML-DmD16-c3  (45) wing disc ML-DmD21  (61) wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (90) eye-antennal disc ML-DmD11  (39) antennal disc ML-DmD20-c5  31 mixed discs ML-DmD4-c1  32 CNS ML-DmBG1-c1  (41) CNS ML-DmBG2-c2  31 tumorous blood cells mbn2  26 ovary fGS/OSS  (33) ovary OSC  (39) ovary OSS  26 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    49 Schneider line 2 Sg4    33 embryonic 1182-4H    26 embryonic GM2    23 embryonic Kc167    21 embryonic S1    40 embryonic S3    34 leg disc CME L1    31 wing disc CME-W2    55 wing disc ML-DmD8    27 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    61 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    90 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    31 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    26 ovary fGS/OSS    33 ovary OSC    39 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    49 Schneider line 2 Sg4    33 embryonic 1182-4H    26 embryonic GM2    23 embryonic Kc167    21 embryonic S1    40 embryonic S3    34 leg disc CME L1    31 wing disc CME-W2    55 wing disc ML-DmD8    27 wing disc ML-DmD9    38 wing disc ML-DmD16-c3    45 wing disc ML-DmD21    61 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    90 eye-antennal disc ML-DmD11    39 antennal disc ML-DmD20-c5    31 mixed discs ML-DmD4-c1    32 CNS ML-DmBG1-c1    41 CNS ML-DmBG2-c2    31 tumorous blood cells mbn2    26 ovary fGS/OSS    33 ovary OSC    39 ovary OSS    26 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    12 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    12 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3  (29) Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult  26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    12 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    12 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    12 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    12 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3  29 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult  26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  26 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    12 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    11 cold shock, 4-day adult    12 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    15 Cadmium 50 mM 12 hrs, larvae L3    29 Cadmium 50 mM 48 hrs, 4-day adult    17 Cadmium 100 mM 48 hrs, 4-day adult    26 Copper 0.5 mM 12 hrs, larvae L3    16 Copper 15 mM 48 hrs, 4-day adult    18 Zinc 5 mM 12 hrs, larvae L3    9 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    22 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    21 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    26 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    23 Paraquat 10 mM 48 hrs, 4-day adult    19 Rotenone 2 μg 12 hrs, larvae L3    24 Rotenone 8 μg 12 hrs, larvae L3    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • SD08021 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013746 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9556-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for alien Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal alienGD4682 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 alienGD4682 Other Phenotypes Allele neuroanatomy defective | larval stage alienGD4682 visible, with Scer\GAL4pnr-MD237 alienGD4682 Phenotype manifest in Allele ganglion mother cell | larval stage alienGD4682 mesothoracic tergum, with Scer\GAL4pnr-MD237 alienGD4682 trichogen cell, with Scer\GAL4pnr-MD237 alienGD4682
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of alien Class Mutagen Stocks Known lesion alienG3386 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of alien Class Mutagen Stocks Known lesion alienGD4682 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes alienHM05119 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6021 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4682} NA P{TRiP.HM05119} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}alienG3386 NA
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
ligand-dependent nuclear receptor binding inferred from physical interaction with EcR (Dressel et al., 1999) nuclear hormone receptor binding inferred from physical interaction with EcR (Dressel et al., 1999) protein binding inferred from physical interaction with CSN5 (Freilich et al., 1999) inferred from physical interaction with CSN7 (Freilich et al., 1999) protein homodimerization activity inferred from physical interaction with alien (Freilich et al., 1999) transcription corepressor activity inferred from direct assay (Dressel et al., 1999)
Biological Process
CV term Evidence References
mitotic G2 DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) negative regulation of transcription, DNA-dependent inferred from direct assay (Dressel et al., 1999) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) protein stabilization inferred from mutant phenotype (Ullah et al., 2007) regulation of cell cycle inferred from direct assay (Guest et al., 2011)
Cellular Component
CV term Evidence References
repressor ecdysone receptor complex inferred from physical interaction with EcR (Dressel et al., 1999) signalosome inferred from physical interaction with CSN5 (Freilich et al., 1999) inferred from physical interaction with CSN7 (Freilich et al., 1999)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
signal transducer activity inferred from sequence or structural similarity with UniProtKB:Q15647 (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15)
Biological Process
CV term Evidence References
signal transduction inferred from sequence or structural similarity with UniProtKB:Q15647 (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15)
Cellular Component
CV term Evidence References
signalosome non-traceable author statement (Freilich, 1999.2.17, Wei and Deng, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
alien - CSN4 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) alien - CSN6 experimental knowledge based (Guruharsha et al., 2011) alien - CSN7 experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions alien allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60337 DroID - A comprehensive database of gene and protein interactions. • FBgn0013746 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34225
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG61VKNS Dipteran inclusive ortholog search EOG6PCB1K Insect inclusive ortholog search EOG6SQVS2 Arthropod inclusive ortholog search EOG61ZCS8 Metazoa inclusive ortholog search EOG66QKKW
Orthologs in Drosophila Species (EOG61VKNS)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\alien     Drosophila simulans   Dsim\GD22368 Y   Drosophila sechellia   Dsec\GM12583 Y   Drosophila erecta   Dere\GG24040 Y   Drosophila yakuba   Dyak\GE10643 Y   Drosophila ananassae   Dana\GF22104 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21877 Y   Drosophila persimilis   Dper\GL25543 Y   Drosophila willistoni   Dwil\GK23707 Y   Drosophila virilis   Dvir\GJ14108 Y   Drosophila mojavensis   Dmoj\GI11968 Y   Drosophila grimshawi   Dgri\GH25117     Drosophila grimshawi   Dgri\GH12954     Drosophila grimshawi   Dgri\GH22257 Y
Orthologs in non-Drosophila Dipterans (EOG6PCB1K)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005730   Anopheles gambiae Malaria mosquito  Agam\AGAP008598   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801795
Orthologs in non-Dipteran Insects (EOG6SQVS2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC409062   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007878   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20767   Atta cephalotes Leafcutter ant  Acep\ACEP27586   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15634   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14559   Linepithema humile Argentine ant  Lhum\LH14737   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20068   Solenopsis invicta Red fire ant  Sinv\SINV20647   Acyrthosiphon pisum Pea aphid  Apim\ACYPI008415   Bombyx mori Silkmoth  Bmor\BGIBMGA013499   Pediculus humanus Human body louse  Phum\PHUM593150   Tribolium castaneum Red flour beetle  Tcas\TC004662
Orthologs in non-Insect Arthropods (EOG61ZCS8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_307388   Ixodes scapularis Deer tick  Isca\ISCW021720
Orthologs in non-Arthropod Metazoa (EOG66QKKW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\csn-2   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_005730gn   Danio rerio Zebrafish  Drer\cops2   Xenopus tropicalis Western clawed frog  Xtro\cops2   Gallus gallus Domestic chicken  Ggal\ENSGALG00000003367   Gallus gallus Domestic chicken  Ggal\COPS2   Mus musculus House mouse  Mmus\Cops2   Rattus norvegicus Norway rat  Rnor\Cops2
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22368 Drosophila sechellia Dsec\GM12583 Drosophila erecta Dere\GG24040 Drosophila yakuba Dyak\GE10643 Drosophila ananassae Dana\GF22104 Drosophila pseudoobscura pseudoobscura Dpse\GA21877 Drosophila persimilis Dper\GL25543 Drosophila willistoni Dwil\GK23707 Drosophila virilis Dvir\GJ14108 Drosophila mojavensis Dmoj\GI11968 Drosophila grimshawi Dgri\GH22257
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	28908 y1 v1; P{TRiP.HM05119}attP2 26910 y1 w*; P{EP}alienG3386
VDRC	v48044 w1118; P{GD4682}v48044
Genomic Clones ( 2 )
	BACR05B09 BACR48E15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 61 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD10463 SD08021
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03402 AT07171 AT27474 GH12411 GH19988 GM06138 GM20952 LD05130 LD07015 LD14719 LD15149 LD18245 LD33915 LD37815 LD43256 RE12777 RE32003 RE37756 RE44740 RE65394 SD07175 SD15013 SD26786
Other clones	165517 568985 EK269854 EN14317 IP09646 IP09746 IP09846 IP09946 LD46201 RP004052266 RP004083425 RP004146346 RP004157805 RP004165247 RP004195125 RP004197374 RP004205215 RP004207975 RP004212259 RP004218684 RP004230482 RP004231440 RP004239134 RP004246422 RP004248192 RP004258204 RP004368064 RP004425096 RP004450084 RP004500064 RP004522534 RP004523947 RP004544511 RP004546069 RP004548910 RP004553221
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0013746 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34225
Antibody Information
	polyclonal (Goubeaud et al., 1996)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: alien BcDNA:LD10463 (FlyBase, 1996-) Source for merge of: alien CH2 (FlyBase, 1996-)
Additional comments	FlyBase curator comment: the insertion in the "f04576" Exelixis line (PBac{WH}CG18661f04576) was originally assigned to the alien gene in FBrf0179797, resulting in the "alienf04576" (FBal0159508) allele. However, FBrf0184340 shows that the insertion is actually within CG18661. (Bloomington Drosophila Stock Center, 2004.11.6) Source for merge of alien BcDNA:LD10463 was a shared cDNA (date:030728). (FlyBase, 1996-) Source for merge of alien CH2 was sequence comparison (date:000117). (FlyBase, 1996-)
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) COP9 signalosome is essential for development. (Freilich et al., 1999) During embryogenesis alien is expressed exclusively in the muscle attachment sites (apodemes) of the somatic muscles in the head, thorax and abdominal segments as well as in the epidermal attachments of the pharynx. (Goubeaud et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078793 NM_164843 NM_001273347 RefSeq (Proteins) • NP_523517 NP_723438 NP_001260276 DDBJ / EMBL / GenBank • AA391270 AAB49932 AAD28604 AAF52736 AAL39981 AAM49874 AAN10685 AF129079 AGB92812 AI546587 AW942135 AW944540 AY069836 AY118505 U57758 Entrez Gene - A searchable database of RefSeq genes. • 34225 UniProtKB/Swiss-Prot • Q94899
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Proteasome component (PCI) domain (IPR000717) PCI/PINT associated module (IPR013143) Winged helix-turn-helix DNA-binding domain (IPR011991) Tetratricopeptide-like helical (IPR011990) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD08021
Linkouts
	BioGRID - A database of protein and genetic interactions • 60337 DroID - A comprehensive database of gene and protein interactions. • FBgn0013746 DRSC - Results from RNAi screens. • FBgn0013746 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013746 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9556-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0013746 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34225 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34225 modMine - Data generated by the modENCODE project. • FBgn0013746
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	Alien (Kozlova and Thummel, 2000, Lier and Paululat, 2001, Paululat et al., 1995) alien (Stroschein-Stevenson et al., 2006, White et al., 2011, Dorus et al., 2006, Guest et al., 2011, Davis et al., 2011) BcDNA:LD10463   CG9556 (Perkins et al., 2009, Haussmann et al., 2008) CH2   CSN2 (Ou et al., 2003, Lier and Paululat, 2001, Deng et al., 2000, Buckley et al., 2007, Kondo and Perrimon, 2011) Csn2 (Ullah et al., 2007, Oron et al., 2007) Dch2 (Wei and Deng, 2003, Freilich et al., 1999) DCH2 (Freilich, 1999.2.17, )
Name Synonym	alien (Davis et al., 2011) Alien (Maier et al., 2006, Schafer et al., 2007) COP9 complex homolog subunit 2 (Freilich, 1999.2.17, ) d-Alien (Dressel et al., 1999) Drosophila COP9 signalosome homolog 2 (Freilich et al., 1999)
Secondary FlyBase IDs
	FBgn0027056 FBgn0063164
References ( 56 )
Generate a list of	All references relating to this gene ( 56 )
List References by type	Research paper  ( 23 ) Supplementary material  ( 7 ) Review  ( 6 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 5 )
	Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Davis et al., 2011, BMC Dev. Biol. 11: 66 Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines. [FBrf0216830] Guest et al., 2011, BMC Syst. Biol. 5(1): 65 A protein network-guided screen for cell cycle regulators in Drosophila. [FBrf0213913] Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] White et al., 2011, J. Cell Biol. 193(4): 677--694 Drosophila histone locus bodies form by hierarchical recruitment of components. [FBrf0213662] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...