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Gene Dmel\alien

General Information
Symbol	Dmel\alien	Species	D. melanogaster
Name	alien	Annotation symbol	CG9556
Feature type	protein_coding_gene	FlyBase ID	FBgn0013746
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	CSN2, Dch2
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	29F7-29F7	Sequence location	2L:8,994,669..8,997,375 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene alien is referred to in FlyBase by the symbol Dmel\alien (CG9556, FBgn0013746). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; nuclear hormone receptor binding; ligand-dependent nuclear receptor binding; protein homodimerization activity; transcription corepressor activity. There is experimental evidence that it is involved in the biological process: protein stabilization; mitotic cell cycle G2/M transition DNA damage checkpoint; negative regulation of transcription, DNA-dependent; neurogenesis; phagocytosis, engulfment. 3 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: PCI/PINT associated module; Proteasome component (PCI) domain; Tetratricopeptide-like helical; Winged helix-turn-helix transcription repressor DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, larval Malpighian tubules, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638830_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of alien. Gene sequence location is 2L:8994669..8997375.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN22157 HFA03482
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 29F7-29F7   Limits computationally determined from genome sequence between P{lacW}l(2)k04003k04003 and P{PZ}tai01351
Experimentally Determined Cytological Location
Cytogenetic map Notes References 29F-30A     (Paululat, 1996.5.8) 29F-30A   (determined by in situ hybridisation)   (Goubeaud et al., 1996)
Experimentally Determined Recombination Data
Location	2- (Paululat, 1996.5.8)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\alien for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) alien-RA FBtr0079780  NM_164843   1504   444 alien-RB FBtr0079781  NM_078793   2317   444
Additional Transcript Data & Comments
Reported size (kB)	1.486 (longest cDNA) (Freilich et al., 1999) 1.4 (northern blot) (Goubeaud et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein alien-PA   FBpp0079381   51.5   444   5.28     NP_723438   AAN10685 alien-PB   FBpp0089195   51.5   444   5.28     NP_523517   AAF52736
Additional Polypeptide Data & Comments
Reported size (kDa)	444 (aa) (Freilich et al., 1999) 360 (aa); 42 (kD predicted) (Goubeaud et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Proteasome component (PCI) domain (IPR000717) PCI/PINT associated module (IPR013143) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991) Tetratricopeptide-like helical (IPR011990)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263724   AA391270   AA440068   AA440125   AA538664   AA816744   AA979379   AE014134 AAF52736   AE014134 AAN10685   AF129079 AAD28604   AI134843   AI239198   AI388935   AI511751   AI518333   AI534373   AI546117   AI546587   AW942135   AW944540   AY069836 AAL39981   AY118505 AAM49874   BF490861   BF494680   BF505016   BG637144   BG639182   BI171098   BI236017   BI240822   BI352824   BI358070   BI482677   BI632890   BX010303   CO317950   CO337338   EC227110   EC263367   EL879723   EL879847   EL879977   EL880111   GH943728   GH946543   GH947119   GH947573   GH947839   GH948482   GH948613   GH951357   GH951525   GH952266   GH956227   GH957703   GH959729   GH960094   GH960397   GH960513   GH962583   GH962625   GH964701   GH968815   GH970602   GH974186   GH978629   GH979805   GH980643   GH981424   GH981517   U57758 AAB49932
UniProtKB/Swiss-Prot	Q94899
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
	alien transcripts are detected in embryos on northern blots. The levels decrease dramatically during embryogenesis. High levels of alien transcripts are detected by in situ hybridization during oogenesis. (Goubeaud et al., 1996)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage   embryonic/larval abdominal 1 intrasegmental apodeme 2 -- embryonic/larval abdominal 7 intrasegmental apodeme 2   (Goubeaud et al., 1996) apodeme of pharynx   (Goubeaud et al., 1996) embryonic/larval abdominal 1 intersegmental apodeme -- embryonic/larval abdominal 7 intersegmental apodeme   (Goubeaud et al., 1996) embryonic/larval intersegmental apodeme   (Goubeaud et al., 1996) embryonic/larval abdominal 1 intrasegmental apodeme 1 -- embryonic/larval abdominal 7 intrasegmental apodeme 1   (Goubeaud et al., 1996) embryonic/larval intrasegmental apodeme   (Goubeaud et al., 1996) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term	cytoplasm (Goubeaud et al., 1996)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0013746    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0013746 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0013746 expression level Developmental Stage   Expression Level embryo 00-02hr    2317 embryo 02-04hr    3721 embryo 04-06hr    2957 embryo 06-08hr    1686 embryo 08-10hr    1874 embryo 10-12hr    1426 embryo 12-14hr    1524 embryo 14-16hr    1012 embryo 16-18hr    1062 embryo 18-20hr    588 embryo 20-22hr    1327 embryo 22-24hr    1530 larva L1    837 larva L2    1222 larva L3 12hr old    958 larva L3 puffstage 1-2    1217 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9    1727 white prepupae new    1636 white prepupae 12hr    1649 white prepupae 24hr    1741 pupae 2d postWPP    1234 pupae 3d postWPP    814 pupae 4d postWPP    430 adult male 01day    913 adult male 05day    936 adult male 30day    845 adult female 01day    935 adult female 05day    1878 adult female 30day    1781 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2317) embryo 02-04hr  (3721) embryo 04-06hr  (2957) embryo 06-08hr  (1686) embryo 08-10hr  (1874) embryo 10-12hr  (1426) embryo 12-14hr  (1524) embryo 14-16hr  (1012) embryo 16-18hr  (1062) embryo 18-20hr  (588) embryo 20-22hr  (1327) embryo 22-24hr  (1530) larva L1  (837) larva L2  (1222) larva L3 12hr old  (958) larva L3 puffstage 1-2  (1217) larva L3 puffstage 3-6  (1301) larva L3 puffstage 7-9  (1727) white prepupae new  (1636) white prepupae 12hr  (1649) white prepupae 24hr  (1741) pupae 2d postWPP  (1234) pupae 3d postWPP  (814) pupae 4d postWPP  (430) adult male 01day  (913) adult male 05day  (936) adult male 30day  (845) adult female 01day  (935) adult female 05day  (1878) adult female 30day  (1781) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2317) embryo 02-04hr  (3721) embryo 04-06hr  (2957) embryo 06-08hr  (1686) embryo 08-10hr  (1874) embryo 10-12hr  1426 embryo 12-14hr  (1524) embryo 14-16hr    1012 embryo 16-18hr    1062 embryo 18-20hr    588 embryo 20-22hr    1327 embryo 22-24hr  (1530) larva L1    837 larva L2    1222 larva L3 12hr old    958 larva L3 puffstage 1-2    1217 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9  (1727) white prepupae new  (1636) white prepupae 12hr  (1649) white prepupae 24hr  (1741) pupae 2d postWPP    1234 pupae 3d postWPP    814 pupae 4d postWPP    430 adult male 01day    913 adult male 05day    936 adult male 30day    845 adult female 01day    935 adult female 05day  (1878) adult female 30day  (1781) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2317 embryo 02-04hr    3721 embryo 04-06hr    2957 embryo 06-08hr    1686 embryo 08-10hr    1874 embryo 10-12hr    1426 embryo 12-14hr    1524 embryo 14-16hr    1012 embryo 16-18hr    1062 embryo 18-20hr    588 embryo 20-22hr    1327 embryo 22-24hr    1530 larva L1    837 larva L2    1222 larva L3 12hr old    958 larva L3 puffstage 1-2    1217 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9    1727 white prepupae new    1636 white prepupae 12hr    1649 white prepupae 24hr    1741 pupae 2d postWPP    1234 pupae 3d postWPP    814 pupae 4d postWPP    430 adult male 01day    913 adult male 05day    936 adult male 30day    845 adult female 01day    935 adult female 05day    1878 adult female 30day    1781 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2317 embryo 02-04hr    3721 embryo 04-06hr    2957 embryo 06-08hr    1686 embryo 08-10hr    1874 embryo 10-12hr    1426 embryo 12-14hr    1524 embryo 14-16hr    1012 embryo 16-18hr    1062 embryo 18-20hr    588 embryo 20-22hr    1327 embryo 22-24hr    1530 larva L1    837 larva L2    1222 larva L3 12hr old    958 larva L3 puffstage 1-2    1217 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9    1727 white prepupae new    1636 white prepupae 12hr    1649 white prepupae 24hr    1741 pupae 2d postWPP    1234 pupae 3d postWPP    814 pupae 4d postWPP    430 adult male 01day    913 adult male 05day    936 adult male 30day    845 adult female 01day    935 adult female 05day    1878 adult female 30day    1781 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0013746 expression level Developmental Stage   Expression Level embryo 00-02hr    2317 embryo 02-04hr    3721 embryo 04-06hr    2957 embryo 06-08hr    1686 embryo 08-10hr    1874 embryo 10-12hr    1426 embryo 12-14hr    1524 embryo 14-16hr    1012 embryo 16-18hr    1062 embryo 18-20hr    588 embryo 20-22hr    1327 embryo 22-24hr    1530 larva L1    837 larva L2    1222 larva L3 12hr old    958 larva L3 puffstage 1-2    1217 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9    1727 white prepupae new    1636 white prepupae 12hr    1649 white prepupae 24hr    1741 pupae 2d postWPP    1234 pupae 3d postWPP    814 pupae 4d postWPP    430 adult male 01day    913 adult male 05day    936 adult male 30day    845 adult female 01day    935 adult female 05day    1878 adult female 30day    1781 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2317) embryo 02-04hr  (3721) embryo 04-06hr  (2957) embryo 06-08hr  (1686) embryo 08-10hr  (1874) embryo 10-12hr  (1426) embryo 12-14hr  (1524) embryo 14-16hr  (1012) embryo 16-18hr  (1062) embryo 18-20hr  (588) embryo 20-22hr  (1327) embryo 22-24hr  (1530) larva L1  (837) larva L2  (1222) larva L3 12hr old  (958) larva L3 puffstage 1-2  (1217) larva L3 puffstage 3-6  (1301) larva L3 puffstage 7-9  (1727) white prepupae new  (1636) white prepupae 12hr  (1649) white prepupae 24hr  (1741) pupae 2d postWPP  (1234) pupae 3d postWPP  (814) pupae 4d postWPP  (430) adult male 01day  (913) adult male 05day  (936) adult male 30day  (845) adult female 01day  (935) adult female 05day  (1878) adult female 30day  (1781) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2317 embryo 02-04hr  (3721) embryo 04-06hr  (2957) embryo 06-08hr  1686 embryo 08-10hr  1874 embryo 10-12hr  1426 embryo 12-14hr  1524 embryo 14-16hr    1012 embryo 16-18hr    1062 embryo 18-20hr    588 embryo 20-22hr    1327 embryo 22-24hr  1530 larva L1    837 larva L2    1222 larva L3 12hr old    958 larva L3 puffstage 1-2    1217 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9  1727 white prepupae new  1636 white prepupae 12hr  1649 white prepupae 24hr  1741 pupae 2d postWPP    1234 pupae 3d postWPP    814 pupae 4d postWPP    430 adult male 01day    913 adult male 05day    936 adult male 30day    845 adult female 01day    935 adult female 05day  1878 adult female 30day  1781 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2317 embryo 02-04hr    3721 embryo 04-06hr    2957 embryo 06-08hr    1686 embryo 08-10hr    1874 embryo 10-12hr    1426 embryo 12-14hr    1524 embryo 14-16hr    1012 embryo 16-18hr    1062 embryo 18-20hr    588 embryo 20-22hr    1327 embryo 22-24hr    1530 larva L1    837 larva L2    1222 larva L3 12hr old    958 larva L3 puffstage 1-2    1217 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9    1727 white prepupae new    1636 white prepupae 12hr    1649 white prepupae 24hr    1741 pupae 2d postWPP    1234 pupae 3d postWPP    814 pupae 4d postWPP    430 adult male 01day    913 adult male 05day    936 adult male 30day    845 adult female 01day    935 adult female 05day    1878 adult female 30day    1781 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2317 embryo 02-04hr    3721 embryo 04-06hr    2957 embryo 06-08hr    1686 embryo 08-10hr    1874 embryo 10-12hr    1426 embryo 12-14hr    1524 embryo 14-16hr    1012 embryo 16-18hr    1062 embryo 18-20hr    588 embryo 20-22hr    1327 embryo 22-24hr    1530 larva L1    837 larva L2    1222 larva L3 12hr old    958 larva L3 puffstage 1-2    1217 larva L3 puffstage 3-6    1301 larva L3 puffstage 7-9    1727 white prepupae new    1636 white prepupae 12hr    1649 white prepupae 24hr    1741 pupae 2d postWPP    1234 pupae 3d postWPP    814 pupae 4d postWPP    430 adult male 01day    913 adult male 05day    936 adult male 30day    845 adult female 01day    935 adult female 05day    1878 adult female 30day    1781 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0013746    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0013746 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval central nervous system, larval Malpighian tubules, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0013746 expression level Tissue   Expression Level Larval Central Nervous System    639.625 Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules    718.6 Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye    525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary    609.4 Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (639.625) Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules  (718.6) Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye  525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary  (609.4) Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    639.625 Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules    718.6 Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye    525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary    609.4 Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    639.625 Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules    718.6 Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye    525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary    609.4 Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0013746 expression level Tissue   Expression Level Larval Central Nervous System    639.625 Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules    718.6 Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye    525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary    609.4 Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  639.625 Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules  718.6 Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye  525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary  609.4 Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    639.625 Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules    718.6 Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye    525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary    609.4 Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    639.625 Larval Midgut    392.5 Larval Hindgut    402.3 Larval Malpighian Tubules    718.6 Larval Fat Body    476.9 Larval Salivary Gland    407.1 Larval Trachea    497.55 Larval Carcass    450.875 Adult Head    375.8 Adult Eye    525.875 Adult Brain    436.3 Adult Thoracic-Abdominal Ganglion    379.5 Adult Crop    358.2 Adult Midgut    345.7 Adult Hindgut    323.5 Adult Malpighian Tubules    346.5 Adult Fat Body    252.7 Adult Salivary Gland    282 Adult Heart    265.175 Adult VirginFemale Spermatheca    461.8 Adult InseminatedFemale Spermatheca    432.7 Adult Ovary    609.4 Adult Testis    263.6 Adult Male Accessory Gland    362.4 Adult Carcass    228.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    375.8   NA  Eye    525.875   NA  Brain    436.3   639.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    379.5   NA  Crop    358.2   392.5  Midgut    345.7   402.3  Hindgut    323.5   718.6  Malpighian Tubules    346.5   476.9  Fat Body    252.7   407.1  Salivary Gland    282   NA  Heart    265.175   497.55  Trachea    NA   NA  VirginFemale Spermatheca    461.8   NA  InseminatedFemale Spermatheca    432.7   NA  Ovary    609.4   NA  Testis    263.6   NA  Male Accessory Gland    362.4   450.875  Carcass    228.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013746 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9556-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for alien Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 alienGD4682 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 alienGD4682 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 alienGD4682 visible, with Scer\GAL4pnr-MD237 alienGD4682 Phenotype manifest in Allele ganglion mother cell | larval stage, with Scer\GAL41407 alienGD4682 mesothoracic tergum, with Scer\GAL4pnr-MD237 alienGD4682 trichogen cell, with Scer\GAL4pnr-MD237 alienGD4682
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of alien Class Mutagen Stocks Known lesion alienG3386 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of alien Class Mutagen Stocks Known lesion alienGD4682 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes alienHM05119 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6021 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4682} NA P{TRiP.HM05119} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}alienG3386 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
ligand-dependent nuclear receptor binding inferred from physical interaction with EcR (Dressel et al., 1999) nuclear hormone receptor binding inferred from physical interaction with EcR (Dressel et al., 1999) protein binding inferred from physical interaction with CSN5 (Freilich et al., 1999) inferred from physical interaction with CSN7 (Freilich et al., 1999) protein homodimerization activity inferred from physical interaction with alien (Freilich et al., 1999) transcription corepressor activity inferred from direct assay (Dressel et al., 1999)
Biological Process
CV term Evidence References
mitotic cell cycle G2/M transition DNA damage checkpoint inferred from genetic interaction with nbs (Kondo and Perrimon, 2011) negative regulation of transcription, DNA-dependent inferred from direct assay (Dressel et al., 1999) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) phagocytosis, engulfment inferred from mutant phenotype (Stroschein-Stevenson et al., 2006) protein stabilization inferred from mutant phenotype (Ullah et al., 2007)
Cellular Component
CV term Evidence References
repressor ecdysone receptor complex inferred from physical interaction with EcR (Dressel et al., 1999) signalosome inferred from physical interaction with CSN5 (Freilich et al., 1999) inferred from physical interaction with CSN7 (Freilich et al., 1999)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
signal transducer activity inferred from sequence or structural similarity with UniProtKB:Q15647 (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15)
Biological Process
CV term Evidence References
signal transduction inferred from sequence or structural similarity with UniProtKB:Q15647 (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15)
Cellular Component
CV term Evidence References
signalosome non-traceable author statement (Freilich, 1999.2.17, Wei and Deng, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions alien allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60337 DroID - A comprehensive database of gene and protein interactions. • FBgn0013746 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34225
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22104 Dere\GG24040 Dgri\GH22257 Dmoj\GI11968 Dper\GL25543 Dpse\GA21877 Dsec\GM12583 Dsim\GD22368 Dvir\GJ14108 Dwil\GK23707 Dyak\GE10643
Curated drosophilid orthologs	Dpse\GA21877
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005730-PA Aedes aegypti (mosquito) AGAP008598-PA Anopheles gambiae (mosquito) XP_392587.2 Apis mellifera (honey bee) XP_001944088.1 Acyrthosiphon pisum (pea aphid) At2g26990.1 Arabidopsis thaliana (wall cress) 90405 Batrachochytrium dendrobatidis (chytrid fungus) 82574 Branchiostoma floridae (lancelet) XP_001895889.1 Brugia malayi (roundworm nematode) BGIBMGA013499-PA Bombyx mori (silk worm) ENSBTAP00000017862 Bos taurus (bovine) ENSBTAP00000051729 Bos taurus (bovine) CAL0004448 Candida albicans (a form of yeast) CN18953 Caenorhabditis brenneri (small nematode) CN20960 Caenorhabditis brenneri (small nematode) CBP30758 Caenorhabditis briggsae (nematode) CE27562 Caenorhabditis elegans (worm) ENSCAFP00000021903 Canis familiaris (dog) ENSCINP00000017753 Ciona intestinalis (sea squirt) JA12796 Caenorhabditis japonica (nematode) CMR159C Cyanidioschyzon merolae (red alga) cn04453 Cryptococcus neoformans (yeast-like fungus) CPIJ010491 Culex pipens (mosquito) ENSCPOP00000003113 Cavia porcellus (guinea pig) 189898 Chlamidomonas reinhardtii (green alga) RP38229 Caenorhabditis remanei (nematode) ENSCSAVP00000010320 Ciona savignyi (sedentary tunicate) 151084 Capitella spl (polychaete worm) DDB0233100 Dictyostelium discoideum (amoeba) DEHA2B11176g Debaryomyces Hansenii (yeast) 307388 Daphnia pulex (daphnia) ENSDARP00000012359 Danio rerio (zebra fish) ENSECAP00000022295 Equus caballus (horse) XP_653344 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000022179 Gymnopilus aculeatus (mushroom) ENSGALP00000000549 Gallus gallus (chicken) 184988 Hypsipyla robusta (cedar shoot borer) ENSP00000299259 Homo sapiens (human) ISCW021720-PA Ixodes scapularis (deer tick) 181363 Lottia gigantea (owl limpet) LmjF25.2210 Leishmania major (virus) 16111 Monocosta brevicollis (choanoflagellate) ENSMODP00000002997 Monodelphis domestica (gray opossum) ENSMMUP00000002949 Macaca mulatta (rhesus monkey) ENSMUSP00000106092 Mus musculus (house mouse) 160233 Nematostella vectensis (starlet anemone) XP_001607475.1 Nasonia vitripennis (wasp) ENSOANP00000016785 Ornithorynchus anatinus (platypus) ENSORLP00000002921 Oryzias latipes (japanese killifish) LOC_Os01g17180.1 Oryza sativa (asian rice) 9469 Ostreococcus tauri (green alga) PHUM002546-PA Pediculus humanus (human body louse) PP29171 Pristionchus pacificus (nematode) 133638 Physcomitrella patens (moss) 165552 Physcomitrella patens (moss) ENSPPYP00000007321 Pongo pygmaeus (orangutan) 75580 Phytophthora ramorum (sudden oak death pathogen) 142424 Phytophthora sojae (root rot pathogen) 558178 Populus trichocarpa (black cottonwood) 583397 Populus trichocarpa (black cottonwood) ENSPTRP00000012052 Pan troglodytes (chimpanzee) ENSRNOP00000012287 Rattus norvegicus (norway rat) 4751741 Sorghum bicolor (sorghum) Smp_020050 Schistosoma mansoni (trematode parasite) SPAPB17E12.04c Schizosaccharomyces pombe (fission yeast) XP_001178268.1 Strongylocentrotus purpuratus (purple sea urchin) 30777 Trichoplax adhaerens (metazoa) XP_969453.1 Tribolium castaneum (red flour beetle) Tc00.1047053508479.260 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000012405 Tetraodon nigroviridis (green spotted pufferfish) TP04_0762 Theileria parva (parasitic protozoan) 35771 Thalassiosira pseudonana (marine diatom) ENSTRUP00000043337 Takifugu rubripes (pufferfish Takifugu) 3829.m01203 Tetrahymena thermophila (ciliate protozoa) 89557.m00028 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000019297 Xenopus tropicalis (frog) YALI0F16874g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13646 LH14737 ISCW021720 FBgn0228495 FBgn0225669 FBgn0201326 FBgn0193774 FBgn0167520 JGI_V11_307388 FBgn0081862 FBgn0163127 FBgn0134725 FBgn0132572 FBgn0129717 FBgn0120432 FBgn0116179 FBgn0099103 CPIJ010491 BGIBMGA013499 ACYPI008415 GB17467 AGAP008598 AAEL005730 PB20068 PHUM593150 GLEAN_04662
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	28908 y1 v1; P{TRiP.HM05119}attP2 26910 y1 w*; P{EP}alienG3386
VDRC	v48044 w1118; P{GD4682}v48044
Genomic Clones ( 2 )
	BACR05B09 BACR48E15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 61 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD10463 SD08021
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03402 AT07171 AT27474 GH12411 GH19988 GM06138 GM20952 LD05130 LD07015 LD14719 LD15149 LD18245 LD33915 LD37815 LD43256 RE12777 RE32003 RE37756 RE44740 RE65394 SD07175 SD15013 SD26786
Other clones	165517 568985 EK269854 EN14317 IP09646 IP09746 IP09846 IP09946 LD46201 RP004052266 RP004083425 RP004146346 RP004157805 RP004165247 RP004195125 RP004197374 RP004205215 RP004207975 RP004212259 RP004218684 RP004230482 RP004231440 RP004239134 RP004246422 RP004248192 RP004258204 RP004368064 RP004425096 RP004450084 RP004500064 RP004522534 RP004523947 RP004544511 RP004546069 RP004548910 RP004553221
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0013746 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34225
Antibody Information
	polyclonal (Goubeaud et al., 1996)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: alien BcDNA:LD10463 (FlyBase, 1996-) Source for merge of: alien CH2 (FlyBase, 1996-)
Additional comments	FlyBase curator comment: the insertion in the "f04576" Exelixis line (PBac{WH}CG18661f04576) was originally assigned to the alien gene in FBrf0179797, resulting in the "alienf04576" (FBal0159508) allele. However, FBrf0184340 shows that the insertion is actually within CG18661. (Bloomington Drosophila Stock Center, 2004.11.6) Source for merge of alien BcDNA:LD10463 was a shared cDNA (date:030728). (FlyBase, 1996-) Source for merge of alien CH2 was sequence comparison (date:000117). (FlyBase, 1996-)
Other Comments
	S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells. (Stroschein-Stevenson et al., 2006) COP9 signalosome is essential for development. (Freilich et al., 1999) During embryogenesis alien is expressed exclusively in the muscle attachment sites (apodemes) of the somatic muscles in the head, thorax and abdominal segments as well as in the epidermal attachments of the pharynx. (Goubeaud et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078793 NM_164843 RefSeq (Proteins) • NP_523517 NP_723438 DDBJ / EMBL / GenBank • AA391270 AAB49932 AAD28604 AAF52736 AAL39981 AAM49874 AAN10685 AF129079 AI546587 AW942135 AW944540 AY069836 AY118505 U57758 Entrez Gene - A searchable database of RefSeq genes. • 34225 UniProtKB/Swiss-Prot • Q94899
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Proteasome component (PCI) domain (IPR000717) PCI/PINT associated module (IPR013143) Winged helix-turn-helix transcription repressor DNA-binding (IPR011991) Tetratricopeptide-like helical (IPR011990)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60337 DroID - A comprehensive database of gene and protein interactions. • FBgn0013746 DRSC - Results from RNAi screens. • FBgn0013746 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013746 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9556-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0013746 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34225 InParanoid A subset of ortholog calls from InParanoid. • AAEL005730-PA Aedes aegypti (mosquito) AGAP008598-PA Anopheles gambiae (mosquito) XP_392587.2 Apis mellifera (honey bee) XP_001944088.1 Acyrthosiphon pisum (pea aphid) At2g26990.1 Arabidopsis thaliana (wall cress) 90405 Batrachochytrium dendrobatidis (chytrid fungus) 82574 Branchiostoma floridae (lancelet) XP_001895889.1 Brugia malayi (roundworm nematode) BGIBMGA013499-PA Bombyx mori (silk worm) ENSBTAP00000017862 Bos taurus (bovine) ENSBTAP00000051729 Bos taurus (bovine) CAL0004448 Candida albicans (a form of yeast) CN18953 Caenorhabditis brenneri (small nematode) CN20960 Caenorhabditis brenneri (small nematode) CBP30758 Caenorhabditis briggsae (nematode) CE27562 Caenorhabditis elegans (worm) ENSCAFP00000021903 Canis familiaris (dog) ENSCINP00000017753 Ciona intestinalis (sea squirt) JA12796 Caenorhabditis japonica (nematode) CMR159C Cyanidioschyzon merolae (red alga) cn04453 Cryptococcus neoformans (yeast-like fungus) CPIJ010491 Culex pipens (mosquito) ENSCPOP00000003113 Cavia porcellus (guinea pig) 189898 Chlamidomonas reinhardtii (green alga) RP38229 Caenorhabditis remanei (nematode) ENSCSAVP00000010320 Ciona savignyi (sedentary tunicate) 151084 Capitella spl (polychaete worm) DDB0233100 Dictyostelium discoideum (amoeba) DEHA2B11176g Debaryomyces Hansenii (yeast) 307388 Daphnia pulex (daphnia) ENSDARP00000012359 Danio rerio (zebra fish) ENSECAP00000022295 Equus caballus (horse) XP_653344 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000022179 Gymnopilus aculeatus (mushroom) ENSGALP00000000549 Gallus gallus (chicken) 184988 Hypsipyla robusta (cedar shoot borer) ENSP00000299259 Homo sapiens (human) ISCW021720-PA Ixodes scapularis (deer tick) 181363 Lottia gigantea (owl limpet) LmjF25.2210 Leishmania major (virus) 16111 Monocosta brevicollis (choanoflagellate) ENSMODP00000002997 Monodelphis domestica (gray opossum) ENSMMUP00000002949 Macaca mulatta (rhesus monkey) ENSMUSP00000106092 Mus musculus (house mouse) 160233 Nematostella vectensis (starlet anemone) XP_001607475.1 Nasonia vitripennis (wasp) ENSOANP00000016785 Ornithorynchus anatinus (platypus) ENSORLP00000002921 Oryzias latipes (japanese killifish) LOC_Os01g17180.1 Oryza sativa (asian rice) 9469 Ostreococcus tauri (green alga) PHUM002546-PA Pediculus humanus (human body louse) PP29171 Pristionchus pacificus (nematode) 133638 Physcomitrella patens (moss) 165552 Physcomitrella patens (moss) ENSPPYP00000007321 Pongo pygmaeus (orangutan) 75580 Phytophthora ramorum (sudden oak death pathogen) 142424 Phytophthora sojae (root rot pathogen) 558178 Populus trichocarpa (black cottonwood) 583397 Populus trichocarpa (black cottonwood) ENSPTRP00000012052 Pan troglodytes (chimpanzee) ENSRNOP00000012287 Rattus norvegicus (norway rat) 4751741 Sorghum bicolor (sorghum) Smp_020050 Schistosoma mansoni (trematode parasite) SPAPB17E12.04c Schizosaccharomyces pombe (fission yeast) XP_001178268.1 Strongylocentrotus purpuratus (purple sea urchin) 30777 Trichoplax adhaerens (metazoa) XP_969453.1 Tribolium castaneum (red flour beetle) Tc00.1047053508479.260 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000012405 Tetraodon nigroviridis (green spotted pufferfish) TP04_0762 Theileria parva (parasitic protozoan) 35771 Thalassiosira pseudonana (marine diatom) ENSTRUP00000043337 Takifugu rubripes (pufferfish Takifugu) 3829.m01203 Tetrahymena thermophila (ciliate protozoa) 89557.m00028 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000019297 Xenopus tropicalis (frog) YALI0F16874g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34225 modMine - Data generated by the modENCODE project. • FBgn0013746 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV13646 LH14737 ISCW021720 FBgn0228495 FBgn0225669 FBgn0201326 FBgn0193774 FBgn0167520 JGI_V11_307388 FBgn0081862 FBgn0163127 FBgn0134725 FBgn0132572 FBgn0129717 FBgn0120432 FBgn0116179 FBgn0099103 CPIJ010491 BGIBMGA013499 ACYPI008415 GB17467 AGAP008598 AAEL005730 PB20068 PHUM593150 GLEAN_04662
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	Alien (Kozlova and Thummel, 2000, Lier and Paululat, 2001, Paululat et al., 1995) alien (Stroschein-Stevenson et al., 2006, White et al., 2011, Dorus et al., 2006) BcDNA:LD10463   CG9556 (Perkins et al., 2009, Haussmann et al., 2008) CH2   CSN2 (Ou et al., 2003, Lier and Paululat, 2001, Deng et al., 2000, Buckley et al., 2007, Kondo and Perrimon, 2011) Csn2 (Ullah et al., 2007) Dch2 (Wei and Deng, 2003, Freilich et al., 1999) DCH2 (Freilich, 1999.2.17, )
Name Synonym	alien   Alien (Maier et al., 2006, Schafer et al., 2007) COP9 complex homolog subunit 2 (Freilich, 1999.2.17, ) d-Alien (Dressel et al., 1999) Drosophila COP9 signalosome homolog 2 (Freilich et al., 1999)
Secondary FlyBase IDs
	FBgn0027056 FBgn0063164
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 5 ) Review  ( 6 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] White et al., 2011, J. Cell Biol. 193(4): 677--694 Drosophila histone locus bodies form by hierarchical recruitment of components. [FBrf0213662] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...