FlyBase Gene Report: Dmel\Awh

General Information

Symbol

Dmel\Awh

Species

D. melanogaster

Name

Arrowhead

Annotation Symbol

CG1072

Feature Type

protein_coding_gene

FlyBase ID

FBgn0013751

Gene Model Status

Current

Stock Availability

16 publicly available

Gene Summary

Arrowhead (Awh) encodes a LIM-homeodomain transcription factor that plays important roles in wing and abdominal development. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

l(3)63Ea

Key Links

Genomic Location

Cytogenetic map

63F4-63F4

Sequence location

3L:3,846,206..3,861,692 [+]

Recombination map

3-9

RefSeq locus

NT_037436 REGION:3846206..3861692

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

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Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN004680160

(assigned by GO_Central )

(Gaudet et al., 2011)

enables DNA-binding transcription factor activity

inferred from sequence or structural similarity with UniProtKB:O60663

(assigned by UniProt )

(UniProt Curators, 2002-)

enables RNA polymerase II transcription regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN004680160

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (6 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in compound eye development

inferred from mutant phenotype

(Roignant et al., 2010)

involved_in imaginal disc development

inferred from mutant phenotype

(assigned by UniProt )

(Curtiss and Heilig, 1997)

involved_in regulation of gene expression

inferred from mutant phenotype

(Roignant et al., 2010)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in neuron differentiation

inferred from biological aspect of ancestor with PANTHER:PTN000654232

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN004680160

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of transcription, DNA-templated

inferred from sequence or structural similarity with UniProtKB:O60663

(assigned by UniProt )

(UniProt Curators, 2002-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000654232

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in nucleus

inferred from sequence or structural similarity with UniProtKB:O60663

(assigned by UniProt )

(UniProt Curators, 2002-)

Gene Group (FlyBase)

LIM HOMEOBOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Arrowhead (Awh) encodes a LIM-homeodomain transcription factor that plays important roles in wing and abdominal development. [Date last reviewed: 2018-09-13]

Gene Group (FlyBase)

LIM HOMEOBOX TRANSCRIPTION FACTORS -: LIM homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. They have two N-terminal LIM domains (cysteine-rich, double-zinc finger motifs) and a centrally located sequence-specific DNA binding homeodomain. (Adapted from PMID:24676471 and FBrf0125444).

Protein Function (UniProtKB)

Probable transcription factor. Required for the establishment of a subset of imaginal tissues: the abdominal histoblasts and the salivary gland imaginal rings.

(UniProt, Q8IRC7)

Summary (Interactive Fly)

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Awh for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Alternative translation stop created by use of multiphasic reading frames within coding region.

Sequence Ontology: Class of Gene

gene_with_stop_codon_read_through

(Jungreis et al., 2011)

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Awh-RA

FBtr0073155

NM_079183

2039

214

Awh-RB

FBtr0073156

NM_168042

2104

275

Awh-RC

FBtr0330070

NM_001274450

2104

287

Awh-RD

FBtr0330071

NM_001274451

2092

271

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Awh-PA

FBpp0073013

24.3

214

8.36

NP_523907

AAF47800

Awh-PB

FBpp0073014

31.0

275

7.82

NP_728906

AAN11572

Awh-PC

FBpp0303103

32.3

287

7.95

NP_001261379

AGB94074

Awh-PD

FBpp0303104

30.6

271

7.53

NP_001261380

AGB94075

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Awh using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Awh_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

central brain anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

hypopharynx anlage

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium