FB2020_02, released Apr 14, 2020

Gene: Dmel\Awh

Open Close
General Information
Symbol
Dmel\Awh
Species
D. melanogaster
Name
Arrowhead
Annotation Symbol
CG1072
Feature Type
protein_coding_gene
FlyBase ID
FBgn0013751
Gene Model Status
Current
Stock Availability
16 publicly available
Gene Snapshot
Arrowhead (Awh) encodes a LIM-homeodomain transcription factor that plays important roles in wing and abdominal development. [Date last reviewed: 2018-09-13]
Other Summaries
Also Known As

l(3)63Ea

Key Links
Genomic Location
Cytogenetic map
63F4-63F4
Sequence location
3L:3,846,206..3,861,692 [+]
Recombination map

3-9

RefSeq locus
NT_037436 REGION:3846206..3861692
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding
Summaries
Gene Group (FlyBase)
LIM HOMEOBOX TRANSCRIPTION FACTORS -
LIM homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. They have two N-terminal LIM domains (cysteine-rich, double-zinc finger motifs) and a centrally located sequence-specific DNA binding homeodomain. (Adapted from PMID:24676471 and FBrf0125444).
Protein Function (UniProtKB)
Probable transcription factor. Required for the establishment of a subset of imaginal tissues: the abdominal histoblasts and the salivary gland imaginal rings.
(UniProt, Q8IRC7)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\Awh or the JBrowse view of Dmel\Awh for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UGA) postulated; FBrf0216884.

gene_with_stop_codon_read_through ; SO:0000697

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.46

Gene model reviewed during 5.56

Alternative translation stop created by use of multiphasic reading frames within coding region.

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Awh-RA
FBtr0073155
NM_079183
2039
214
Awh-RB
FBtr0073156
NM_168042
2104
275
Awh-RC
FBtr0330070
NM_001274450
2104
287
Awh-RD
FBtr0330071
NM_001274451
2092
271
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Awh-PA
FBpp0073013
24.3
214
8.36
NP_523907
AAF47800
Awh-PB
FBpp0073014
31.0
275
7.82
NP_728906
AAN11572
Awh-PC
FBpp0303103
32.3
287
7.95
NP_001261379
AGB94074
Awh-PD
FBpp0303104
30.6
271
7.53
NP_001261380
AGB94075
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Awh using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (10 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
DNA-binding transcription factor activity
inferred from sequence or structural similarity with UniProtKB:O60663
(assigned by UniProt )
(UniProt Curators, 2002-)
DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from biological aspect of ancestor with PANTHER:PTN000654232
(assigned by GO_Central )
(Gaudet et al., 2011)
RNA polymerase II regulatory region sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000654232
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
compound eye development
inferred from mutant phenotype
(Roignant et al., 2010)
imaginal disc development
inferred from mutant phenotype
(assigned by UniProt )
(Curtiss and Heilig, 1997)
regulation of gene expression
inferred from mutant phenotype
(Roignant et al., 2010)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
neuron differentiation
inferred from biological aspect of ancestor with PANTHER:PTN000654232
(assigned by GO_Central )
(Gaudet et al., 2011)
positive regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN000654232
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of transcription, DNA-templated
inferred from sequence or structural similarity with UniProtKB:O60663
(assigned by UniProt )
(UniProt Curators, 2002-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000654232
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with UniProtKB:O60663
(assigned by UniProt )
(UniProt Curators, 2002-)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4 -- 6
central brain anlage in statu nascendi
(Fisher et al., 2012)
antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 7 -- 8
antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)
hypopharynx anlage
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
hypopharynx inclusive primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
atrium | precursor

Comment: reported as atrium primordium

(Fisher et al., 2012)
central brain primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
hypopharynx proper primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
atrium
(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic hypopharynx
(Fisher et al., 2012)
embryonic stage 11
posterior spiracle primordium | restricted

Comment: outer region

(Zhai et al., 2010)
embryonic abdominal segment | restricted
(Sato and Shibuya, 2013)
embryonic stage 13
posterior spiracle primordium

Comment: anterior boundary

(Zhai et al., 2010)
embryonic segment | restricted
(Sato and Shibuya, 2013)
embryonic abdominal segment | restricted
(Sato and Shibuya, 2013)
embryonic head segment | restricted
(Sato and Shibuya, 2013)
embryonic thoracic segment | restricted
(Sato and Shibuya, 2013)
histoblast nest
(Sato and Shibuya, 2013)
third instar larval stage
eye-antennal disc | restricted | ventral
(Roignant et al., 2010)
embryonic stage 14
embryonic abdomen | segmentally repeated
(Preger-Ben Noon et al., 2016)
embryonic thorax | segmentally repeated
(Preger-Ben Noon et al., 2016)
embryonic head | restricted
(Preger-Ben Noon et al., 2016)
Additional Descriptive Data

At embryonic stage 11, Awh is expressed only in the outer region of the posterior spiracle primordium located in the eighth abdominal segment. From stage 13 its expression is restricted to the anterior boundary of the posterior spiracle primordium. Expression in the central region of the spiracle primordium is repressed by Abd-B.

(Zhai et al., 2010)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Awh in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 31 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Awh
Transgenic constructs containing regulatory region of Awh
Deletions and Duplications ( 17 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal | larval stage | recessive
lethal | pupal stage | recessive
lethal | recessive
lethal - all die before end of embryonic stage | recessive
lethal - all die before end of pupal stage (with Awh63Ea-E12)
lethal - all die before end of pupal stage (with Awh63Ea-G14)
lethal - all die before end of pupal stage | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female fertile
male fertile
Other Phenotypes
Allele
some die during embryonic stage | recessive
some die during pupal stage (with Awh63Ea-E12)
some die during pupal stage (with Awh63Ea-G14)
some die during pupal stage | recessive
visible
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4ey.PH
visible | dominant
visible | recessive
Phenotype manifest in
Allele
abdominal segment | pharate adult stage | somatic clone
anterior vertical bristle, with Scer\GAL4Bx-MS1096
capitellum, with Scer\GAL4Bx-MS1096
coxa, with Scer\GAL4Bx-MS1096
eye
eye, with Scer\GAL4ey.PH
eye | ventral, with Scer\GAL4Bx-MS1096
eye-antennal disc
eye-antennal disc, with Scer\GAL4Bx-MS1096
eye disc | somatic clone | third instar larval stage, with Scer\GAL4αTub84B.PL
femur, with Scer\GAL4Bx-MS1096
genitalia, with Scer\GAL4Bx-MS1096
histoblast nest (with Awh4)
histoblast nest (with Awh12)
photoreceptor cell | precursor
photoreceptor cell | somatic clone | third instar larval stage, with Scer\GAL4αTub84B.PL
polytene chromosome puff
posterior vertical bristle, with Scer\GAL4Bx-MS1096
pupal spiracle
salivary gland imaginal ring
salivary gland imaginal ring (with Awh10)
salivary gland imaginal ring (with Awh12)
vibrissae, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4Bx-MS1096
wing disc, with Scer\GAL4Bx-MS1096
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (37)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\LHX8
12 of 15
Yes
Yes
Hsap\LHX6
10 of 15
No
Yes
 
Hsap\LMO1
2 of 15
No
No
 
Hsap\CRIP1
1 of 15
No
No
Hsap\CRIP2
1 of 15
No
No
Hsap\CRIP3
1 of 15
No
No
Hsap\DMBX1
1 of 15
No
Yes
Hsap\DUX4L5
1 of 15
No
Yes
Hsap\DUX4L6
1 of 15
No
Yes
Hsap\DUX4L7
1 of 15
No
Yes
Hsap\FHL1
1 of 15
No
Yes
Hsap\GSC2
1 of 15
No
No
Hsap\GSC
1 of 15
No
No
Hsap\HOXB8
1 of 15
No
No
Hsap\LDB3
1 of 15
No
No
Hsap\LHX1
1 of 15
No
No
 
Hsap\LHX2
1 of 15
No
No
 
Hsap\LHX3
1 of 15
No
No
Hsap\LHX4
1 of 15
No
No
Hsap\LHX5
1 of 15
No
No
Hsap\LHX9
1 of 15
No
No
 
Hsap\LMO2
1 of 15
No
No
 
Hsap\LMO3
1 of 15
No
No
 
Hsap\LMO4
1 of 15
No
No
Hsap\LMX1A
1 of 15
No
No
Hsap\LMX1B
1 of 15
No
No
Hsap\LPXN
1 of 15
No
No
 
Hsap\PAX6
1 of 15
No
No
 
Hsap\PDLIM1
1 of 15
No
No
Hsap\PDLIM3
1 of 15
No
No
Hsap\PDLIM7
1 of 15
No
No
Hsap\PITX1
1 of 15
No
No
 
Hsap\PITX3
1 of 15
No
No
Hsap\SHOX2
1 of 15
No
No
Hsap\SHOX
1 of 15
No
No
 
Hsap\ZFHX3
1 of 15
No
No
Hsap\ZFHX4
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (33)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Lhx8
12 of 15
Yes
Yes
Mmus\Lhx6
11 of 15
No
Yes
Mmus\Lmo1
2 of 15
No
No
Mmus\Crip1
1 of 15
No
No
Mmus\Crip2
1 of 15
No
No
Mmus\Crip3
1 of 15
No
No
Mmus\Dmbx1
1 of 15
No
Yes
Mmus\Fhl1
1 of 15
No
Yes
Mmus\Fhl4
1 of 15
No
Yes
Mmus\Gsc2
1 of 15
No
No
Mmus\Gsc
1 of 15
No
No
Mmus\Ldb3
1 of 15
No
No
Mmus\Lhx1
1 of 15
No
No
Mmus\Lhx2
1 of 15
No
No
Mmus\Lhx3
1 of 15
No
No
Mmus\Lhx4
1 of 15
No
No
Mmus\Lhx5
1 of 15
No
No
Mmus\Lhx9
1 of 15
No
No
Mmus\Lmo2
1 of 15
No
No
Mmus\Lmo3
1 of 15
No
No
Mmus\Lmo4
1 of 15
No
No
Mmus\Lmx1a
1 of 15
No
No
Mmus\Lmx1b
1 of 15
No
No
Mmus\Pax6
1 of 15
No
No
 
Mmus\Pdlim1
1 of 15
No
No
Mmus\Pdlim3
1 of 15
No
No
Mmus\Pdlim5
1 of 15
No
No
Mmus\Pdlim7
1 of 15
No
No
Mmus\Pitx1
1 of 15
No
No
Mmus\Pitx3
1 of 15
No
No
Mmus\Shox2
1 of 15
No
No
Mmus\Zfhx3
1 of 15
No
No
Mmus\Zfhx4
1 of 15
No
No
Rattus norvegicus (Norway rat) (20)
Rnor\Lhx8
9 of 13
Yes
Yes
Rnor\Lhx6
5 of 13
No
Yes
Rnor\Lmo1
2 of 13
No
No
Rnor\Crip1
1 of 13
No
No
Rnor\Crip2
1 of 13
No
No
Rnor\Crip3
1 of 13
No
No
Rnor\Fhl1
1 of 13
No
Yes
Rnor\Fhl4
1 of 13
No
Yes
Rnor\Lhx1
1 of 13
No
No
Rnor\Lhx2
1 of 13
No
No
Rnor\Lhx3
1 of 13
No
No
Rnor\Lhx5
1 of 13
No
No
Rnor\Lhx9
1 of 13
No
No
Rnor\Lmo2
1 of 13
No
No
Rnor\Lmo3
1 of 13
No
No
Rnor\Lmo4
1 of 13
No
No
Rnor\Lmx1a
1 of 13
No
No
Rnor\Lmx1b
1 of 13
No
No
Rnor\Zfhx3
1 of 13
No
No
Rnor\Zfhx4
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (25)
Xtro\lhx8
11 of 12
Yes
Yes
Xtro\lhx6
5 of 12
No
Yes
Xtro\crip1
1 of 12
No
No
Xtro\crip2
1 of 12
No
No
Xtro\crip3
1 of 12
No
No
Xtro\fhl1
1 of 12
No
Yes
Xtro\gsc
1 of 12
No
No
Xtro\hoxb8
1 of 12
No
No
Xtro\lhx1
1 of 12
No
No
Xtro\lhx2
1 of 12
No
No
Xtro\lhx3
1 of 12
No
No
Xtro\lhx5
1 of 12
No
No
Xtro\lhx9
1 of 12
No
No
Xtro\lmo2
1 of 12
No
No
Xtro\lmo4.1
1 of 12
No
No
Xtro\lmo4.2
1 of 12
No
No
Xtro\lmx1a
1 of 12
No
No
Xtro\lmx1b.1
1 of 12
No
No
Xtro\lmx1b.2
1 of 12
No
No
Xtro\pdlim5
1 of 12
No
No
Xtro\pitx1
1 of 12
No
No
Xtro\pitx3
1 of 12
No
No
Xtro\shox2
1 of 12
No
No
Xtro\zfhx3
1 of 12
No
No
Xtro\zfhx4
1 of 12
No
No
Danio rerio (Zebrafish) (43)
Drer\lhx6
10 of 15
Yes
Yes
Drer\lhx8a
7 of 15
No
Yes
Drer\LOC799481
6 of 15
No
Yes
Drer\si:ch211-236k19.2
5 of 15
No
Yes
Drer\crip2
1 of 15
No
No
Drer\crip3
1 of 15
No
No
Drer\dmbx1a
1 of 15
No
Yes
Drer\dmbx1b
1 of 15
No
Yes
Drer\fhl1a
1 of 15
No
Yes
Drer\fhl1b
1 of 15
No
Yes
Drer\gsc
1 of 15
No
No
Drer\hoxb8a
1 of 15
No
No
Drer\ldb3a
1 of 15
No
No
Drer\lhx2a
1 of 15
No
No
Drer\lhx2b
1 of 15
No
No
Drer\lhx3
1 of 15
No
No
Drer\lhx4
1 of 15
No
No
Drer\lhx5
1 of 15
No
No
Drer\lhx9
1 of 15
No
No
Drer\lmo1
1 of 15
No
No
Drer\lmo2
1 of 15
No
No
Drer\lmo3
1 of 15
No
No
Drer\lmo4a
1 of 15
No
No
Drer\lmo4b
1 of 15
No
No
Drer\lmx1a
1 of 15
No
No
Drer\lmx1al
1 of 15
No
No
Drer\lmx1ba
1 of 15
No
No
Drer\lmx1bb
1 of 15
No
No
Drer\mxtx2
1 of 15
No
No
Drer\pax6a
1 of 15
No
No
Drer\pax6b
1 of 15
No
No
Drer\pdlim3b
1 of 15
No
No
Drer\pdlim5b
1 of 15
No
No
Drer\pdlim7
1 of 15
No
No
Drer\pitx1
1 of 15
No
No
Drer\pitx3
1 of 15
No
No
Drer\shox2
1 of 15
No
No
Drer\shox
1 of 15
No
No
Drer\si:dkey-90l8.3
1 of 15
No
No
Drer\zfhx3
1 of 15
No
No
Drer\zfhx4
1 of 15
No
No
Drer\zgc:56628
1 of 15
No
No
Drer\zgc:101840
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\lim-4
11 of 15
Yes
Yes
Cele\alp-1
1 of 15
No
No
Cele\ceh-45
1 of 15
No
No
Cele\ceh-51
1 of 15
No
No
Cele\mec-3
1 of 15
No
No
Cele\vab-3
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (7)
Atha\HAT1
1 of 9
Yes
No
Atha\HAT3
1 of 9
Yes
Yes
Atha\HAT22
1 of 9
Yes
No
Atha\HB4
1 of 9
Yes
No
Atha\HB21
1 of 9
Yes
No
Atha\HB40
1 of 9
Yes
No
Atha\HB53
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\PHO2
2 of 15
Yes
No
Scer\PXL1
2 of 15
Yes
No
Scer\YHP1
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\phx1
1 of 12
Yes
No
Spom\pxl1
1 of 12
Yes
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190C14 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00007545
Drosophila simulans
Dsim\GD13784
Drosophila sechellia
Dsec\GM14592
Drosophila erecta
Dere\GG15164
Drosophila yakuba
Dyak\GE21383
Drosophila ananassae
Dana\GF24228
Drosophila pseudoobscura pseudoobscura
Dpse\GA10520
Drosophila persimilis
Dper\GL25299
Drosophila willistoni
Dwil\GK20529
Drosophila virilis
Dvir\GJ12418
Drosophila mojavensis
Dmoj\GI12512
Drosophila grimshawi
Dgri\GH16430
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150AL0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017887
Glossina morsitans
Tsetse fly
Gmor\GMOY007999
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13268
Mayetiola destructor
Hessian fly
Mdes\Mdes000934
Mayetiola destructor
Hessian fly
Mdes\Mdes000935
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013765
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013168
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL011247
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013763
Anopheles darlingi
American malaria mosquito
Adar\ADAC001343
Anopheles darlingi
American malaria mosquito
Adar\ADAC005269
Anopheles gambiae
Malaria mosquito
Agam\AGAP006536
Anopheles gambiae
Malaria mosquito
Agam\AGAP006540
Anopheles gambiae
Malaria mosquito
Agam\AGAP006537
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002984
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002985
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002981
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002983
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08NR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA003888
Danaus plexippus
Monarch butterfly
Dple\DPOGS202998-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011021
Apis florea
Little honeybee
Aflo\5289030420
Apis florea
Little honeybee
Aflo\5626667604
Apis mellifera
Western honey bee
Amel\GB53183
Apis mellifera
Western honey bee
Amel\GB53253
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15076
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15092
Bombus terrestris
Buff-tailed bumblebee
Bter\15212318
Bombus terrestris
Buff-tailed bumblebee
Bter\15212319
Linepithema humile
Argentine ant
Lhum\LH15609
Linepithema humile
Argentine ant
Lhum\LH15610
Linepithema humile
Argentine ant
Lhum\LH15601
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0018a0
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG026786
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10275
Tribolium castaneum
Red flour beetle
Tcas\Awh
Pediculus humanus
Human body louse
Phum\PHUM019530
Rhodnius prolixus
Kissing bug
Rpro\RPRC011793
Cimex lectularius
Bed bug
Clec\CLEC000015
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007424
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_15287
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0DY7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR009666
Strigamia maritima
European centipede
Smar\SMAR001118
Ixodes scapularis
Black-legged tick
Isca\ISCW011461
Ixodes scapularis
Black-legged tick
Isca\ISCW022561
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70482.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM56751.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59833.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79706.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur26g00170
Tetranychus urticae
Two-spotted spider mite
Turt\tetur13g04490
Tetranychus urticae
Two-spotted spider mite
Turt\tetur13g04500
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_65174
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_4176
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_13685
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0EXT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Awh
Gallus gallus
Domestic chicken
Ggal\LHX6
Gallus gallus
Domestic chicken
Ggal\LHX8
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (13)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
ap
2 of 10
Lim1
2 of 10
Lmx1a
2 of 10
CG4328
1 of 10
CG34367
1 of 10
ey
1 of 10
Gsc
1 of 10
Lim3
1 of 10
repo
1 of 10
toy
1 of 10
Zasp52
1 of 10
Zasp66
1 of 10
zfh2
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    LHX8; LIM homeobox 8
    12 of 15
    604425
        LHX6; LIM homeobox 6
        10 of 15
        608215
             
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Awh
            suppressible
            Chi
            (Roignant et al., 2010)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Wnk
            suppressible
            Awh
            (Sato and Shibuya, 2013)
            External Data
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            Pathways
            Signaling Pathways (FlyBase)
            Metabolic Pathways
            External Data
            Linkouts
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3L
            Recombination map

            3-9

            Cytogenetic map
            63F4-63F4
            Sequence location
            3L:3,846,206..3,861,692 [+]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            63F4-63F4
            Limits computationally determined from genome sequence between P{PZ}kst01318 and P{PZ}Sc205634
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            63E3-63E9
            (Curtiss, 1996.12.17)
            Experimentally Determined Recombination Data
            Location

            3-9

            (FlyBase, 2016)

            3-8.0

            (Comeron et al., 2012)
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (16)
            Genomic Clones (27)
            cDNA Clones (60)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of

            Source for identity of: Awh CG1072

            (Shue, 1999.11)
            Source for database merge of
            Additional comments
            Other Comments

            Awh is necessary for establishment of proper numbers of cells within a subset of imaginal precursor tissues. Awh may be part of a regulatory pathway responsible for establishing the proper number of abdominal histoblasts and salivary gland imaginal ring cells.

            (Curtiss and Heilig, 1995)

            Discussed during genetic analysis of the Ras64B-Rop region.

            (Harrison et al., 1995)

            Awh is necessary for establishment of proper numbers of cells within a subset of imaginal precursor tissues.

            Loss-of-function alleles are recessive lethal. Gain-of-function alleles show a dominant small eye phenotype, and result in the complete absence of the eye when homozygous.

            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 42 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            modMine - A data warehouse for the modENCODE project
            Linkouts
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            Synonyms and Secondary IDs (11)
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (80)