Gene model reviewed during 5.44
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Bro using the Feature Mapper tool.
Bro transcripts are observed at low, uniform levels in syncytial blastoderm embryos. Transcript levels increase during the blastoderm stage up to the time of cellularization. Transcript levels decline following the completion of cellularization and the onset of gastrulation. A low level of uniformly distributed transcripts is seen during subsequent stages of embryogenesis.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Bro in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Cloned in a low stringency hybridisation screen using full length mouse PEBP2β as a probe. In vitro studies reveal Bro stimulates the DNA binding activity of the run domain. run can act as an active repressor in the presence of either partner protein (Bro or Bgb).
Identified in a yeast two-hybrid system, by screening for run-interacting proteins.
The gene is named 'Brother', for 'Beta for Runt and others'.