FB2019_05, released Oct 15, 2019

Gene: Dmel\cnn

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General Information
Symbol
Dmel\cnn
Species
D. melanogaster
Name
centrosomin
Annotation Symbol
CG4832
Feature Type
protein_coding_gene
FlyBase ID
FBgn0013765
Gene Model Status
Current
Stock Availability
19 publicly available
Gene Snapshot
centrosomin (cnn) encodes an essential mitotic centrosome component. During early embryogenesis it is required to organize the mitotic spindle, the actin cytoskeleton and centriole replication. It is also required for mitotic and meiotic divisions during spermatogenesis, as well as organization of the sperm axoneme. The product of cnn can interact with microtubules, actin and the kinase encoded by polo. [Date last reviewed: 2019-05-23]
Other Summaries
Also Known As
oblivious, mat(2)syn-C, obv
Key Links
Genomic Location
Cytogenetic map
50A8-50A9
Sequence location
2R:13,439,314..13,450,475 [-]
Recombination map
2-68
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
protein binding
Predictions / Assertions
-
Summaries
Protein Function (UniProtKB)
Core component of the centrosome throughout spermatogenesis. May participate in mitotic spindle assembly and the mechanics of morphogenesis through an interaction with microtubules, either directly or indirectly. Is a target of several homeotic genes.
(UniProt, P54623)
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
12
Number of Unique Polypeptides
10

Please see the GBrowse view of Dmel\cnn or the JBrowse view of Dmel\cnn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.41
Multiphase exon postulated: exon reading frame differs in alternative transcripts; overlap >20aa.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.45
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
cnn-RA
FBtr0087703
NM_057736
4322
1148
cnn-RB
FBtr0087704
NM_165990
4621
1120
cnn-RD
FBtr0100654
NM_001014523
4140
1090
cnn-RE
FBtr0100656
NM_001038855
4651
1130
cnn-RG
FBtr0301395
NM_001169670
1709
480
cnn-RH
FBtr0306635
NM_001259367
1824
462
cnn-RI
FBtr0309888
NM_001259362
1769
500
cnn-RJ
FBtr0309889
NM_165991
4830
1320
cnn-RK
FBtr0309890
NM_001259363
2006
520
cnn-RL
FBtr0309891
NM_001259364
5012
1378
cnn-RM
FBtr0309892
NM_001259365
4399
1120
cnn-RN
FBtr0309893
NM_001259366
4310
1120
Additional Transcript Data and Comments
Reported size (kB)
5.0, 4.5, 4.3 (northern blot)
(Li et al., 1998)
5.0, 4.8 (northern blot)
(Heuer et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
cnn-PA
FBpp0086822
129.9
1148
5.01
NP_477084
AAF58375
cnn-PB
FBpp0086823
126.8
1120
5.19
NP_725297
AAM68579
cnn-PD
FBpp0100116
123.7
1090
5.29
NP_001014523
AAX52706
cnn-PE
FBpp0100117
128.0
1130
5.22
NP_001033944
ABC66061
cnn-PG
FBpp0290609
53.8
480
7.07
NP_001163141
ACZ94414
cnn-PH
FBpp0297590
52.2
462
7.63
NP_001246296
AFH08050
cnn-PI
FBpp0301622
55.9
500
7.33
NP_001246291
AFH08045
cnn-PJ
FBpp0301623
149.5
1320
5.97
NP_725298
AAF58376
cnn-PK
FBpp0301624
58.4
520
6.02
NP_001246292
AFH08046
cnn-PL
FBpp0301625
155.7
1378
5.44
NP_001246293
AFH08047
cnn-PM
FBpp0301626
126.8
1120
5.19
NP_001246294
AFH08048
cnn-PN
FBpp0301627
126.8
1120
5.19
NP_001246295
AFH08049
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1120 aa isoforms: cnn-PB, cnn-PM, cnn-PN
Additional Polypeptide Data and Comments
Reported size (kDa)
1106 (aa); 150, 120 (kD observed); 124 (kD predicted)
(Li et al., 1998)
1033 (aa); 118 (kD predicted)
(Heuer et al., 1995)
Comments
External Data
Subunit Structure (UniProtKB)
Monomer.
(UniProt, P54623)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\cnn using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (17 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
protein binding
inferred from physical interaction with FLYBASE:Sas-4; FB:FBgn0011020
(Gopalakrishnan et al., 2011)
inferred from physical interaction with FLYBASE:Cen; FB:FBgn0032876
(Kao and Megraw, 2009)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (12 terms)
Terms Based on Experimental Evidence (12 terms)
CV Term
Evidence
References
asymmetric cell division
inferred from direct assay
(Lucas and Raff, 2007)
asymmetric neuroblast division
inferred from mutant phenotype
(Cabernard and Doe, 2009)
central nervous system development
inferred from mutant phenotype
(Heuer et al., 1995)
centriole replication
inferred from direct assay
(Lucas and Raff, 2007)
centrosome cycle
inferred from mutant phenotype
(Blachon et al., 2009, Dobbelaere et al., 2008, Megraw et al., 1999)
embryonic cleavage
inferred from mutant phenotype
(Eisman et al., 2009, Kao and Megraw, 2009)
midgut development
inferred from mutant phenotype
(Heuer et al., 1995)
mitotic spindle organization
inferred from mutant phenotype
(Moutinho-Pereira et al., 2013)
peripheral nervous system development
inferred from mutant phenotype
(Heuer et al., 1995)
photoreceptor cell morphogenesis
inferred from mutant phenotype
(Chen et al., 2011)
pole cell formation
inferred from mutant phenotype
(Lerit and Gavis, 2011)
regulation of centriole-centriole cohesion
inferred from mutant phenotype
(Conduit and Raff, 2010)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
centriole
inferred from direct assay
(Conduit and Raff, 2010, Blachon et al., 2009)
centrosome
inferred from direct assay
(Eisman and Kaufman, 2013, Eisman et al., 2009, Li and Kaufman, 1996, Heuer et al., 1995)
pericentriolar material
inferred from direct assay
(Gopalakrishnan et al., 2011, Conduit et al., 2010, Blachon et al., 2009, Dobbelaere et al., 2008)
spindle pole
inferred from direct assay
(Eisman et al., 2009)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
pericentriolar material
non-traceable author statement
(Gonzalez and Bornens, 2000)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)
embryonic stage 5
(Heuer et al., 1995)
embryonic stage 6 -- 7
ventral furrow
(Heuer et al., 1995)
cephalic furrow
(Heuer et al., 1995)
embryonic stage 7 -- 8
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium

Comment: reported as ventral nerve cord anlage

(Fisher et al., 2012)
embryonic stage 9 -- 10
central brain primordium
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 10
neuroblast
(Heuer et al., 1995)
embryonic stage 11
peripheral nervous system
(Heuer et al., 1995)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 16
visceral mesoderm | restricted
(Heuer et al., 1995)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
embryonic stage 14
central nervous system
(Heuer et al., 1995)
brain
(Heuer et al., 1995)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 9
organism
(Li et al., 1998)
adult stage | male
testis
(Li et al., 1998)
adult stage | female
ovary
(Li et al., 1998)
Additional Descriptive Data
cnn transcripts are first detected at stage 5. High levels are present in gastrulating embryos along the ventral and cephalic furrows and later in the mesoderm. By stage 10, expression is seen in neuroblasts of the CNS, and by stage 11 in the PNS. By stage 14, expression is stronger in the thoracic part of the nerve cord than in the abdominal region and can be seen in the brain hemispheres as well. From stage 11-16, expression is observed in two domains of the visceral mesoderm surrounding the midgut. Double labeling shows that the anterior domain is located just anterior to cells expressing Scr and the posterior domain overlaps with cells expressing Antp and Ubx.
(Heuer et al., 1995)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 4
(Vaizel-Ohayon and Schejter, 1999)
embryo
(Lecuyer et al., 2007)
embryonic stage 5
(Heuer et al., 1995)
embryonic stage 6 -- 7
ventral furrow
(Heuer et al., 1995)
cephalic furrow
(Heuer et al., 1995)
embryonic stage 10
neuroblast
(Heuer et al., 1995)
embryonic stage 11
peripheral nervous system
(Heuer et al., 1995)
embryonic stage 14
brain
(Heuer et al., 1995)
central nervous system
(Heuer et al., 1995)
embryonic stage 14 -- 16
visceral mesoderm of embryonic midgut constriction 2
(Heuer et al., 1995)
visceral mesoderm of gastric caecum
(Heuer et al., 1995)
late embryonic stage
scolopidial neuron
(Chen et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Li et al., 1998)
adult stage | male
spermatogonium
(Li et al., 1998)
testis
(Li et al., 1998)
spermatocyte
(Li et al., 1998)
adult stage & oogenesis
ovary
(Li et al., 1998)
spermatogenesis & adult stage
testis
(Li et al., 1998)
Additional Descriptive Data
cnn protein localizes to the centrosomes of the first zygotic nucleus. This centrosomal association persists throughout the 13 synchronous rounds of nuclear divisions of the syncytial embryo. During the syncytial divisions, cnn protein is found at all microtubule-organizing centers. The centrosome localization is not dependent on the presence of an intact microtubule cytoskeleton.
(Vaizel-Ohayon and Schejter, 1999)
cnn protein is expressed at high levels during both mitotic and meiotic divisions. It is closely associated with the centrosomes in a cell-dependent manner throughout spermatogenesis. During spermatogonial cell mitoses, cnn protein is strongly detected at spindle poles. At interphases it is present in centrosomes at much lower levels and is found at high levels in the cytoplasm. During the rapid growth phase of primary spermatocytes, cnn protein is in close association with the centriole. In each spermatocyte, two dots of cnn staining are seen at the membrane, representing the duplicated centrosomes. Later, as cells approach the meiotic divisions, the centrosomes migrate back to the nuclear membranes and higher levels of cnn protein staining are seen in the centrosomes. Accumulation of FBgn0013765:cnn protein in the spermatocyte centrosomes is not dependent on the presence of microtubules. FBgn0013765:cnn protein is detected in the centrosomes during both meiotic divisions. During meiosis II, there is a single centriole in each centrosome. In postmeiotic cells, the single centriole inserts into the nucleus and becomes the basal body. FBgn0013765:cnn @ protein is detected in the basal body until the early stages of axonemal elongation.
(Li et al., 1998)
The pattern of cnn protein distribution is essentially identical to that of cnn transcripts. Immunostaining demonstrates that there are more cells toward the ventral midline in the thoracic neuromeres that express cnn protein compared to the abdominal neuromeres. Furthermore, cnn protein and transcript expression patterns are not identical in the visceral mesoderm. cnn protein is not visible in the visceral mesoderm at late germ band retraction but is observed in stages 14-16 in the visceral mesoderm of the gastric caecae and the second midgut constriction.
(Heuer et al., 1995)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
centriole
inferred from direct assay
(Conduit and Raff, 2010, Blachon et al., 2009)
centrosome
inferred from direct assay
(Eisman and Kaufman, 2013, Eisman et al., 2009, Li and Kaufman, 1996, Heuer et al., 1995)
pericentriolar material
inferred from direct assay
(Gopalakrishnan et al., 2011, Conduit et al., 2010, Blachon et al., 2009, Dobbelaere et al., 2008)
spindle pole
inferred from direct assay
(Eisman et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\cnn in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 23 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 27 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of cnn
Transgenic constructs containing regulatory region of cnn
Deletions and Duplications ( 9 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal (with Df(2R)BSC306)
lethal | maternal effect
lethal - all die before end of embryonic stage
lethal - all die before end of embryonic stage, with Df(2R)cnn/cnnHK21, Scer\GAL4VP16.nos.UTR
lethal - all die before end of embryonic stage (with Df(2R)cnn), with Scer\GAL4VP16.nos.UTR, cnnS22A.PA.UASp.EGFP
lethal - all die before end of embryonic stage (with Df(2R)cnn), with Scer\GAL4VP16.nos.UTR, cnnS22A.T27A.PA.UASp.EGFP
lethal - all die before end of embryonic stage (with Df(2R)cnn), with Scer\GAL4VP16.nos.UTR, cnnT27A.PA.UASp.EGFP
lethal - all die before end of embryonic stage | maternal effect, with Df(2R)cnn/cnnHK21
lethal - all die before end of embryonic stage | maternal effect, with Scer\GAL4VP16.nos.UTR
lethal - all die before end of embryonic stage | maternal effect (with cnn25cn1)
lethal - all die before end of embryonic stage | maternal effect (with cnnHK21)
lethal - all die before end of embryonic stage | maternal effect (with Df(2R)cnn), with cnnΔEx1A
lethal - all die before end of embryonic stage | maternal effect | recessive
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority die | maternal effect, with Scer\GAL4VP16.nos.UTR, cnnmfs3
partially lethal - majority die | maternal effect, with Scer\GAL4VP16.nos.UTR, cnnmfs7
partially lethal - majority die | maternal effect, with Scer\GAL4VP16.nos.UTR, cnnPA.UASp.GFP
partially lethal - majority die | maternal effect, with Scer\GAL4VP16.nos.UTR, cnnS22A.PA.UASp.EGFP
partially lethal - majority die | maternal effect, with Scer\GAL4VP16.nos.UTR, cnnS22A.T27A.PA.UASp.EGFP
partially lethal - majority die | maternal effect, with Scer\GAL4VP16.nos.UTR, cnnT27A.PA.UASp.EGFP
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
viable, with Scer\GAL4αTub84B.PL
Sterility
Allele
female sterile
female sterile | recessive
fertile
fertile, with Scer\GAL4αTub84B.PL
male fertile
male sterile
male sterile | recessive
Other Phenotypes
Allele
cell cycle defective
cytokinesis defective | male (with Df(2R)cnn)
meiotic cell cycle defective | dominant
meiotic cell cycle defective | maternal effect (with Df(2R)cnn)
mitotic cell cycle defective
neuroanatomy defective | third instar larval stage
non-suppressor of variegation | dominant, with In(1)wm4
non-suppressor of variegation | dominant, with P{hsp26-pt-T}39C-5
size defective | third instar larval stage
some die during embryonic stage
some die during embryonic stage | maternal effect, with Scer\GAL4VP16.nos.UTR
some die during embryonic stage | maternal effect (with cnn25cn1)
some die during embryonic stage | maternal effect (with cnnHK21)
some die during embryonic stage | maternal effect (with Df(2R)cnn)
some die during embryonic stage | recessive | maternal effect | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
wild-type
Phenotype manifest in
Allele
axoneme
centriolar satellite, with Scer\GAL4VP16.nos.UTR
centriole
centrosome
centrosome, with Scer\GAL4VP16.nos.UTR
centrosome & male germline stem cell
centrosome | embryonic stage 4
cleavage furrow | embryonic stage
cyst progenitor cell (with cnnHK21)
cyst progenitor cell (with cnnmfs3)
embryo
embryo | maternal effect
embryonic/larval brain | third instar larval stage
embryonic cortex & actin filament
ganglion mother cell | somatic clone
male germline stem cell & centrosome
male germline stem cell & spindle
male germline stem cell | supernumerary
male germline stem cell | supernumerary (with cnnHK21)
male germline stem cell | supernumerary (with cnnmfs3)
meiosis I & aster
meiotic cell cycle | male
meiotic spindle | embryonic stage | maternal effect (with Df(2R)cnn)
mitotic cell cycle
mitotic spindle | third instar larval stage
neuroblast
neuroblast | somatic clone | supernumerary
neuroblast | supernumerary
nuclear chromosome | embryonic stage | maternal effect
nucleus | embryonic stage, with Df(2R)cnn/cnnHK21, Scer\GAL4VP16.nos.UTR
nucleus | embryonic stage (with Df(2R)cnn), with Scer\GAL4VP16.nos.UTR, cnnS22A.PA.UASp.EGFP
nucleus | embryonic stage (with Df(2R)cnn), with Scer\GAL4VP16.nos.UTR, cnnS22A.T27A.PA.UASp.EGFP
nucleus | embryonic stage (with Df(2R)cnn), with Scer\GAL4VP16.nos.UTR, cnnT27A.PA.UASp.EGFP
nucleus | embryonic stage | maternal effect
nucleus | embryonic stage | maternal effect, with Df(2R)cnn/cnnmfs3
nucleus | embryonic stage | maternal effect, with Df(2R)cnn/cnnmfs7
nucleus | embryonic stage | maternal effect (with Df(2R)cnn), with cnnΔEx1A
pericentriolar material | embryonic stage 4
pole cell
pole cell | maternal effect
spermatid
spermatocyte
spermatocyte & spindle
spindle
spindle (with cnnHK21)
spindle (with cnnmfs3)
spindle | embryonic stage
spindle | embryonic stage 4
spindle | embryonic stage | maternal effect
spindle | embryonic stage | maternal effect, with Df(2R)cnn/cnnmfs3
spindle | embryonic stage | maternal effect, with Df(2R)cnn/cnnmfs7
spindle | embryonic stage | maternal effect (with Df(2R)cnn), with cnnΔEx1A
wing
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\CDK5RAP2
4 of 15
Yes
Yes
Hsap\LOC653513
2 of 15
No
Yes
Hsap\PDE4DIP
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Cdk5rap2
4 of 15
Yes
Yes
Mmus\Pde4dip
2 of 15
No
Yes
Mmus\Sptan1
1 of 15
No
No
Rattus norvegicus (Norway rat) (3)
Rnor\Cdk5rap2
2 of 13
Yes
Yes
Rnor\Ccdc141
1 of 13
No
No
Rnor\Pde4dip
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
Xtro\cdk5rap2
1 of 12
Yes
Yes
Xtro\pde4dip
1 of 12
Yes
Yes
Xtro\sptan1
1 of 12
Yes
No
Xtro\sptbn2
1 of 12
Yes
No
Xtro\sptbn5
1 of 12
Yes
No
Danio rerio (Zebrafish) (4)
Drer\si:ch211-242b18.1
2 of 15
Yes
Yes
Drer\zgc:55582
2 of 15
Yes
Yes
Drer\sptbn1
1 of 15
No
No
Drer\triob
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190105 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\cnn
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006578
Drosophila simulans
Dsim\GD25761
Drosophila sechellia
Dsec\GM20278
Drosophila erecta
Dere\GG22491
Drosophila yakuba
Dyak\GE13363
Drosophila ananassae
Dana\GF11185
Drosophila pseudoobscura pseudoobscura
Dpse\GA18464
Drosophila persimilis
Dper\GL17401
Drosophila willistoni
Dwil\GK10742
Drosophila virilis
Dvir\GJ21311
Drosophila mojavensis
Dmoj\GI18938
Drosophila grimshawi
Dgri\GH23115
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915044Z )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17013745
Musca domestica
House fly
Mdoa\17005811
Glossina morsitans
Tsetse fly
Gmor\GMOY005830
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09836
Mayetiola destructor
Hessian fly
Mdes\Mdes008411
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008110
Anopheles darlingi
American malaria mosquito
Adar\ADAC007491
Anopheles gambiae
Malaria mosquito
Agam\AGAP002434
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011971
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011593
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ011594
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05GG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis florea
Little honeybee
Aflo\2615240980
Apis mellifera
Western honey bee
Amel\GB45937
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10314
Bombus terrestris
Buff-tailed bumblebee
Bter\15213001
Linepithema humile
Argentine ant
Lhum\LH20338
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0019b4
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002605
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11373
Tribolium castaneum
Red flour beetle
Tcas\cnn
Rhodnius prolixus
Kissing bug
Rpro\RPRC006641
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05CJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58384.1
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
cnnHK21
model of  microcephaly
CEA with mad2G6595
(Poulton et al., 2017)
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
CDK5RAP2; CDK5 regulatory subunit associated protein 2
4 of 15
608201
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser
View in Interactions Browser
Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
cnn
molecular sieving, light scattering, x-ray crystallography, two hybrid, anti tag coimmunoprecipitation, western blot, nuclear magnetic resonance
(Citron et al., 2018, Feng et al., 2017, Galletta et al., 2016, Eisman et al., 2015, Conduit et al., 2014)
cnn - CG14309
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - CG15435
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - CG18190
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - CG31326
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - CG5726
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - CG6927
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - Cam
nuclear magnetic resonance
(Citron et al., 2018)
cnn - Cen
two hybrid
(Kao and Megraw, 2009)
cnn - Cep135
two hybrid
(Galletta et al., 2016)
cnn - Cep97
two hybrid
(Galletta et al., 2016)
cnn - Cnb
anti tag coimmunoprecipitation, peptide massfingerprinting, western blot
(Januschke et al., 2013)
cnn - Cp110
two hybrid
(Galletta et al., 2016)
cnn - Cp190
cosedimentation in solution, western blot
(Gopalakrishnan et al., 2011)
cnn - DCP1
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - Ge-1
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - Gp210
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - Grip71
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - Grip75
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - Grip84
anti bait coimmunoprecipitation, western blot, peptide massfingerprinting
(Habermann et al., 2012)
cnn - Hsp27
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - LBR
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - Lam
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - Lk6
two hybrid
(Galletta et al., 2016)
cnn - Mzt1
pull down, western blot
(Tovey et al., 2018)
cnn - Nek2
two hybrid
(Galletta et al., 2016)
cnn - Nup98-96
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - Ote
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - Plp
anti bait coimmunoprecipitation, western blot, two hybrid, cosedimentation through density gradient, cosedimentation in solution, nuclear magnetic resonance, anti tag western blot
(Citron et al., 2018, Galletta et al., 2016, Lerit et al., 2015, Richens et al., 2015, Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011, Conduit et al., 2010)
cnn - Sas-4
pull down, western blot, anti bait coimmunoprecipitation, cosedimentation through density gradient, anti tag coimmunoprecipitation, anti tag western blot, two hybrid, peptide massfingerprinting
(Galletta et al., 2016, Conduit et al., 2015, Zheng et al., 2014, Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011, Conduit et al., 2010)
cnn - Sas-6
two hybrid
(Galletta et al., 2016)
cnn - ana1
two hybrid
(Galletta et al., 2016)
cnn - ana2
two hybrid
(Galletta et al., 2016)
cnn - ana3
two hybrid
(Galletta et al., 2016)
cnn - apt
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - asl
anti bait coimmunoprecipitation, anti tag western blot, two hybrid, cosedimentation in solution, western blot, cosedimentation through density gradient
(Galletta et al., 2016, Gopalakrishnan et al., 2012, Gopalakrishnan et al., 2011, Conduit et al., 2010)
cnn - aurA
two hybrid, pull down, autoradiography, anti tag coimmunoprecipitation, western blot
(Galletta et al., 2016, Terada et al., 2003)
cnn - ball
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - bel
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - cup
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - eIF3c
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - ewg
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - fzr
anti tag coimmunoprecipitation, peptide massfingerprinting
(Meghini et al., 2016)
cnn - mael
anti bait coimmunoprecipitation, western blot, peptide massfingerprinting, genetic interference
(Sato et al., 2011)
cnn - ndl
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - polo
anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation
(Eisman et al., 2016, Eisman et al., 2015)
cnn - qua
anti bait coimmunoprecipitation, peptide massfingerprinting
(Habermann et al., 2012)
cnn - spd-2
two hybrid, anti bait coimmunoprecipitation, peptide massfingerprinting, western blot, anti tag coimmunoprecipitation, anti tag western blot
(Gambarotto et al., 2019, Galletta et al., 2016, Conduit et al., 2014, Habermann et al., 2012, Conduit et al., 2010)
cnn - sstn
anti tag coimmunoprecipitation, peptide massfingerprinting
(Liu et al., 2015)
cnn - tacc
two hybrid
(Galletta et al., 2016)
cnn - βTub56D
anti bait coimmunoprecipitation, anti tag western blot
(Gopalakrishnan et al., 2011)
cnn - γTub23C
pull down, western blot, anti bait coimmunoprecipitation
(Tovey et al., 2018, Habermann et al., 2012, Terada et al., 2003)
cnn - γTub37C
anti bait coimmunoprecipitation, western blot, pull down
(Habermann et al., 2012, Terada et al., 2003)
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement
View in Interactions Browser
Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
cnn
enhanceable
msd1
(Wainman et al., 2009)
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
baz
enhanceable
cnn
(Chen et al., 2011)
Cen
enhanceable
cnn
(Kao and Megraw, 2009)
mad2
enhanceable
cnn
(Rahmani et al., 2009)
msd1
enhanceable
cnn
(Wainman et al., 2009)
External Data
Subunit Structure (UniProtKB)
Monomer.
(UniProt, P54623 )
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Gene Group - Pathway Membership (FlyBase)
External Data
Linkouts
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map
2-68
Cytogenetic map
50A8-50A9
Sequence location
2R:13,439,314..13,450,475 [-]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
50A8-50A9
Limits computationally determined from genome sequence between P{EP}DpEP358 and P{lacW}drkk13809&P{EP}mip120EP606
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
50A-50A
(Li, 1995.9.7)
50A3-50A6
(determined by in situ hybridisation)
(Heuer et al., 1995)
Experimentally Determined Recombination Data
Location
2-68
(FlyBase, 2016)
2-72.3
(Comeron et al., 2012)
2-
(Li, 1995.9.7)
2-65
(Schupbach and Wieschaus, 1989)
Left of (cM)
(Vaizel-Ohayon and Schejter, 1999)
Right of (cM)
Notes
Stocks and Reagents
Stocks (19)
Genomic Clones (27)
cDNA Clones (73)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
BDGP DGC clones
Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    polyclonal
    (Eisman et al., 2015, Eisman and Kaufman, 2013, Eisman et al., 2009, Vaizel-Ohayon and Schejter, 1999, Heuer et al., 1995)
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Source for merge of: cnn oblivious
    (Vaizel-Ohayon and Schejter, 1999)
    Source for merge of: cnn mat(2)syn-C
    (Megraw et al., 1999)
    Source for merge of: cnn CG18370
    (FlyBase, 1996-)
    Additional comments
    Source for merge of cnn CG18370 was sequence comparison ( date:001104 ).
    (FlyBase, 1996-)
    Other Comments
    cnn is required for efficient recruitment of pericentriolar material.
    (Dobbelaere et al., 2008)
    Gene expression is increased in response to the presence of either one or two copies of Scer\GAL4hs.PB.
    (Liu and Lehmann, 2008)
    RNAi screen using dsRNA made from templates generated with primers directed against this gene causes decreased γ-tubulin staining at the spindle pole when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
    (Goshima et al., 2007)
    SL2 cells treated with dsRNA against cnn do not show a significant difference in the mitotic index compared to control cells. The treated cells show anastral bipolar spindle arrangements, with anastral poles that are often barrel-shaped and unfocused, however in spite of these abnormalities, anaphase progresses normally in these cells without and increase in abnormal chromosome arrangement compared to control cells.
    (Muller et al., 2006)
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    (Kiger et al., 2003)
    cnn is required for the assembly and function of centrosomes during the syncytial cleavage divisions in the embryo.
    (Megraw et al., 1999)
    Transcription start sites of cnn and cbs are separated by a mere 134bp. Overall orientation not stated: cnn- cbs+
    (Megraw, 1999.3.3)
    cnn is an essential core component of early embryonic centrosomes.
    (Vaizel-Ohayon and Schejter, 1999)
    cnn is required for spindle organisation during male meiosis and for organisation of the sperm axoneme.
    (Li et al., 1998)
    Maternal effect mutations at the cnn locus prevent the correct restructuring of cortical microfilaments in the early embryo.
    (Schejter et al., 1997)
    cnn function is required for synchronous nuclear divisions in the early embryo, and for various morphological processes in the female and male germlines.
    (Schejter et al., 1997)
    Protein product associated with centrosomes during blastoderm cell cycles and then with centrosomes of mitotic cells.
    (Li and Kaufman, 1996)
    cnn exists as a monomer in the cytoplasm and is phosphorylated.
    (Li and Kaufman, 1996)
    cnn is an essential component of the centrosome, it is localised to the centrosome independent of microtubules. Postblastoderm stage cnn localisation and localisation during spermatogenesis and oogenesis is cell-cycle-dependent.
    (Li and Kaufman, 1996)
    Identified by immunopurification as a target gene for Antp. cnn encodes a centrosomal protein, may be involved in the assembly of mitotic spindles and maps to a genomic region required for midgut morphogenesis.
    (Heuer et al., 1995)
    Identification: cnn was identified in a screen for genomic DNA bound by homeotic proteins.
    (Li et al., 1995)
    Genetic, cell biological and biochemical data suggest that the cnn product controls morphogenesis through mediating microtubule organization and is homeotically regulated.
    (Li et al., 1995)
    Mutation in cnn results in a maternal effect phenotype with defects during syncytial blastoderm formation.
    (Schupbach and Wieschaus, 1989)
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 95 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (17)
    Reported As
    Symbol Synonym
    CG 4832
    (Mahoney et al., 2006)
    CG18370
    CG4832
    (Neuert et al., 2017, Ni et al., 2011.7.19, Müller et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Dobbelaere et al., 2008, Ni et al., 2008, Goshima et al., 2007, Rebollo et al., 2004, Goldstein and Gunawardena, 2000)
    CNN
    (Citron et al., 2018, Pimenta-Marques et al., 2016, Fu et al., 2015, Osses and Henríquez, 2014, Januschke et al., 2013, Wang et al., 2013, Wang et al., 2011, Li et al., 2010, Martins et al., 2010, Savoian and Glover, 2010, Anderson et al., 2009, Brust-Mascher et al., 2009, Martins et al., 2009, Rath et al., 2009, Kotadia et al., 2008, Rodrigues-Martins et al., 2008, Basto et al., 2007, Lecuyer et al., 2007, Rodrigues-Martins et al., 2007, Tanentzapf et al., 2007, Wang et al., 2006, Chodagam et al., 2005, Yang et al., 2005, Butcher et al., 2004, Lin, 2003, Yu et al., 2003, Cha et al., 2002, Lemos et al., 2000, Moritz et al., 1998)
    Cnn
    (Magnaghi-Jaulin et al., 2019, Citron et al., 2018, Ramani et al., 2018, Tillery et al., 2018, Feng et al., 2017, Lattao et al., 2017, Khire et al., 2016, Meghini et al., 2016, Eisman et al., 2015, Homem et al., 2015, Yalgin et al., 2015, Hayward et al., 2014, Sechi et al., 2014, Singh et al., 2014, Zheng et al., 2014, Moutinho-Pereira et al., 2013, Fabian and Brill, 2012, Gopalakrishnan et al., 2012, Guilgur et al., 2012, Reschen et al., 2012, Roque et al., 2012, Cho et al., 2011, Mottier-Pavie et al., 2011, Richter et al., 2011, Sabino et al., 2011, Szafer-Glusman et al., 2011, Van Damme et al., 2011, Fabian et al., 2010, Godin et al., 2010, Bucciarelli et al., 2009, Krahn et al., 2009, Mottier-Pavie and Megraw, 2009, Moutinho-Pereira et al., 2009, Rebollo et al., 2009, Robinett et al., 2009, Sheng et al., 2009, Stevens et al., 2009, Vale et al., 2009, Zhang et al., 2009, Basto et al., 2008, Dobbelaere et al., 2008, Eisman et al., 2008, Goshima et al., 2008, Maurange et al., 2008, Mottier et al., 2008, Pimenta-Marques et al., 2008, Rodrigues-Martins et al., 2008, Rogers et al., 2008, Bonaccorsi et al., 2007, Dix and Raff, 2007, Dix and Raff, 2007, Giansanti et al., 2007, Goshima et al., 2007, Pandey et al., 2007, Peel et al., 2007, Rebollo et al., 2007, Rusan and Peifer, 2007, Varmark et al., 2007, Basto et al., 2006, Bowman et al., 2006, Hutterer et al., 2006, Maiato et al., 2006, Schneider et al., 2006, Slack et al., 2006, Verollet et al., 2006, Siller et al., 2005, Yamashita et al., 2005, Blagden and Glover, 2003, Riggs et al., 2003, Megraw et al., 2001, Li et al., 1998, Li, 1995.9.7, Li et al., 1995)
    Cnn1
    (Bechstedt et al., 2010)
    cen
    (Emery et al., 2005)
    cnn
    (Gambarotto et al., 2019, Guan et al., 2019, Hughes and Simmonds, 2019, Hughes et al., 2018, Riparbelli et al., 2018, Tovey et al., 2018, Golub et al., 2017, Neuert et al., 2017, Poulton et al., 2017, Transgenic RNAi Project members, 2017-, John et al., 2016, Ramdas Nair et al., 2016, Sanghavi et al., 2016, Zheng et al., 2016, Baumbach et al., 2015, Chen et al., 2015, Conduit et al., 2015, Eisman et al., 2015, Gene Disruption Project members, 2015-, Liu et al., 2015, Rodrigues et al., 2015, Venkei and Yamashita, 2015, Ashwal-Fluss et al., 2014, Conduit et al., 2014, Gallaud et al., 2014, Zaytseva et al., 2014, Eisman and Kaufman, 2013, Jauffred et al., 2013, Yadlapalli and Yamashita, 2013, Yamashita, 2013, Fabian and Brill, 2012, Habermann et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Sanghavi et al., 2012, Tao et al., 2012, Chen et al., 2011, Cheng et al., 2011, Gopalakrishnan et al., 2011, Lerit and Gavis, 2011, Sato et al., 2011, Taniguchi et al., 2011, Taniguchi et al., 2011, Wertheim et al., 2011, Buffin and Gho, 2010, Conduit and Raff, 2010, Conduit et al., 2010, Cunha et al., 2010, Gan et al., 2010, Inaba et al., 2010, Moutinho-Pereira et al., 2010, Müller et al., 2010, Riparbelli and Callaini, 2010, Blachon et al., 2009, Cabernard and Doe, 2009, Eisman et al., 2009, Kao and Megraw, 2009, Meireles et al., 2009, Rahmani et al., 2009, Wainman et al., 2009, Blachon et al., 2008, Castellanos et al., 2008, Doheny et al., 2008, Giansanti et al., 2008, Liu and Lehmann, 2008, Megraw et al., 2008, Siller and Doe, 2008, Somma et al., 2008, Wei et al., 2008, Bakal et al., 2007, Brunk et al., 2007, Brunk et al., 2007, Buffin et al., 2007, Cabernard et al., 2007, Christensen and Cook, 2007.3.22, Christensen and Cook, 2007.3.22, Christensen and Cook, 2007.5.8, Egger et al., 2007, Georlette et al., 2007, Lucas and Raff, 2007, Rickmyre et al., 2007, Riparbelli et al., 2007, Slack et al., 2007, Yamashita et al., 2007, Yamashita et al., 2007, Zhang and Megraw, 2007, Colombie et al., 2006, Eisman et al., 2006, Lee et al., 2006, Mahoney et al., 2006, Muller et al., 2006, Nystul and Spradling, 2006, Riparbelli and Callaini, 2005, Yamashita et al., 2005, Raynaud-Messina et al., 2004)
    mat(2)syn-C
    (Schupbach, 1992)
    mat(2)synHK21
    (Schupbach and Wieschaus, 1989)
    mfs
    obv
    (Vaizel-Ohayon and Schejter, 1999)
    Name Synonyms
    Centrosmin
    (Jankovics and Brunner, 2006)
    Centrosomin
    (Homem et al., 2015, Hayward et al., 2014, Wallace et al., 2014, Fabian and Brill, 2012, Guilgur et al., 2012, Matunis et al., 2012, Sabino et al., 2011, Van Damme et al., 2011, Godin et al., 2010, Leatherman and Dinardo, 2010, Blachon et al., 2009, Merkle et al., 2009, Rebollo et al., 2009, Robinett et al., 2009, Sheng et al., 2009, Stevens et al., 2009, Eisman et al., 2008, Holtzman et al., 2008, Mottier et al., 2008, Pimenta-Marques et al., 2008, Rogers et al., 2008, Somma et al., 2008, Bonaccorsi et al., 2007, Pandey et al., 2007, Rebollo et al., 2007, Rusan and Peifer, 2007, Zhang and Megraw, 2007, Abdu et al., 2006, Basto et al., 2006, Bowman et al., 2006, Riparbelli and Callaini, 2005, Siller et al., 2005, Yamashita et al., 2005)
    centrosomin
    (John et al., 2016, Eisman et al., 2015, Fu et al., 2015, Yalgin et al., 2015, Gallaud et al., 2014, Taniguchi et al., 2014, Eisman and Kaufman, 2013, Lerit and Rusan, 2013, Moutinho-Pereira et al., 2013, Yadlapalli and Yamashita, 2013, Gatti et al., 2012, Chen et al., 2011, Cheng et al., 2011, Cho et al., 2011, Lerit and Gavis, 2011, Buffin and Gho, 2010, Conduit and Raff, 2010, Conduit et al., 2010, Fabian et al., 2010, Moutinho-Pereira et al., 2010, Savoian and Glover, 2010, Cabernard and Doe, 2009, Eisman et al., 2009, Kao and Megraw, 2009, Meireles et al., 2009, Rahmani et al., 2009, Rath et al., 2009, Szalontai et al., 2009, Vale et al., 2009, Wainman et al., 2009, Wainman et al., 2009, Giansanti et al., 2008, Goshima et al., 2008, Hoopfer et al., 2008, Kotadia et al., 2008, Rodrigues-Martins et al., 2008, Siller and Doe, 2008, Brunk et al., 2007, Buffin et al., 2007, Goshima et al., 2007, Lucas and Raff, 2007, Rickmyre et al., 2007, Riparbelli et al., 2007, Slack et al., 2007, Tanentzapf et al., 2007, Deshpande et al., 2006, Payne and Braun, 2006, Verollet et al., 2006, Pearson et al., 2005, Yang et al., 2005, McHugh et al., 2004, Raynaud-Messina et al., 2004)
    maternal effect syncytial blastoderm arrest C
    oblivious
    (Vaizel-Ohayon and Schejter, 1999, Schejter et al., 1997)
    Secondary FlyBase IDs
    • FBgn0002675
    • FBgn0020264
    • FBgn0033839
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
    Title
    References (384)