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Gene Dmel\cnn

General Information
Symbol	Dmel\cnn	Species	D. melanogaster
Name	centrosomin	Annotation symbol	CG4832
Feature type	protein_coding_gene	FlyBase ID	FBgn0013765
Gene Model Status	Current	Stock availability	13 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map	2-65
Cytogenetic map	50A8-50A9	Sequence location	2R:9,326,819..9,337,980 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene centrosomin is referred to in FlyBase by the symbol Dmel\cnn (CG4832, FBgn0013765). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 14 unique biological process terms, many of which group under: cellular component organization or biogenesis; cell cycle; single-organism developmental process; system development; cell cycle process; multicellular organismal development; organelle organization; biological regulation; cell fate commitment; pole cell development; M phase of meiotic cell cycle; microtubule organizing center organization; stem cell division; digestive tract development; cellular process. 38 alleles are reported. The phenotypes of these alleles are annotated with: organelle; multicellular structure; organ system; cytoplasmic part; anatomical structure; centrosome; spindle; extended germ band embryo; intracellular organelle part; cell cycle; spindle microtubule; adult segment. It has 12 annotated transcripts and 12 annotated polypeptides. Protein features are: Spindle associated. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult ovary, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635619_a_at completely aligns to an exonic region of only a subset of 5 of the 6 FlyBase-annotated transcript isoforms of cnn. Gene sequence location is 2R:9326819..9337980.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 50A8-50A9   Limits computationally determined from genome sequence between P{EP}DpEP358 and P{lacW}drkk13809&P{EP}mip120EP606
Experimentally Determined Cytological Location
Cytogenetic map Notes References 50A-50A     (Li, 1995.9.7) 50A3-50A6   (determined by in situ hybridisation)   (Heuer et al., 1995)
Experimentally Determined Recombination Data
Location	2-65 (Schupbach and Wieschaus, 1989, ) 2- (Li, 1995.9.7)
Left of (cM)	arr (Vaizel-Ohayon and Schejter, 1999)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\cnn for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41 Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.45 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Multiphase exon postulated: exon reading frame differs in alternative transcripts.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) cnn-RA FBtr0087703  NM_057736   4322   1148 cnn-RB FBtr0087704  NM_165990   4621   1120 cnn-RD FBtr0100654  NM_001014523   4140   1090 cnn-RE FBtr0100656  NM_001038855   4651   1130 cnn-RG FBtr0301395  NM_001169670   1709   480 cnn-RH FBtr0306635  NM_001259367   1824   462 cnn-RI FBtr0309888  NM_001259362   1769   500 cnn-RJ FBtr0309889  NM_165991   4830   1320 cnn-RK FBtr0309890  NM_001259363   2006   520 cnn-RL FBtr0309891  NM_001259364   5012   1378 cnn-RM FBtr0309892  NM_001259365   4399   1120 cnn-RN FBtr0309893  NM_001259366   4310   1120
Additional Transcript Data & Comments
Reported size (kB)	5.0, 4.8 (northern blot) (Heuer et al., 1995) 5.0, 4.5, 4.3 (northern blot) (Li et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein cnn-PA   FBpp0086822   129.9   1148   5.01     NP_477084   AAF58375 cnn-PB   FBpp0086823   126.8   1120   5.19     NP_725297   AAM68579 cnn-PD   FBpp0100116   123.7   1090   5.29     NP_001014523   AAX52706 cnn-PE   FBpp0100117   128.0   1130   5.22     NP_001033944   ABC66061 cnn-PG   FBpp0290609   53.8   480   7.07     NP_001163141   ACZ94414 cnn-PH   FBpp0297590   52.2   462   7.63     NP_001246296   AFH08050 cnn-PI   FBpp0301622   55.9   500   7.33     NP_001246291   AFH08045 cnn-PJ   FBpp0301623   149.5   1320   5.97     NP_725298   AAF58376 cnn-PK   FBpp0301624   58.4   520   6.02     NP_001246292   AFH08046 cnn-PL   FBpp0301625   155.7   1378   5.44     NP_001246293   AFH08047 cnn-PM   FBpp0301626   126.8   1120   5.19     NP_001246294   AFH08048 cnn-PN   FBpp0301627   126.8   1120   5.19     NP_001246295   AFH08049
Additional Polypeptide Data & Comments
Reported size (kDa)	1106 (aa); 150, 120 (kD observed); 124 (kD predicted) (Li et al., 1998) 1033 (aa); 118 (kD predicted) (Heuer et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Spindle associated (IPR012943)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201656   AA264375   AA441667   AA441675   AA539856   AA540199   AA735897   AA949715   AA950762   AA979285   AE013599 AAF58375   AE013599 AAF58376   AE013599 AAM68579   AE013599 AAX52706   AE013599 ABC66061   AC006488   AC007452   AE013599 ACZ94414   AE013599 AFH08045   AE013599 AFH08046   AE013599 AFH08047   AE013599 AFH08048   AE013599 AFH08049   AE013599 AFH08050   AI106714   AI259106   AI456568   AI511992   AI515488   AI944609   AI945384   AI945914   AI946795   AW942518   BF486735   BF488801   BF489158   BF489453   BF490865   BF491771   BF491772   BF492214   BF492304   BF493526   BF493947   BF494982   BF496398   BF496979   BF501011   BF501264   BF501559   BF504695   BF505005   BF505100   BF506127   BF506566   BG634568   BI167905   BI172974   BI231980   BI232019   BI232873   BI242045   BI362423   BI367443   BI485487   BI580901   BT001287 AAN71043   BT003808   BT010053 AAQ22522   BT021269 AAX33417   BZ665588   CL527835   CO189830   CO266402   CO272593   CO277375   CO293614   CO298371   CO310720   CO324835   CZ476209   CZ478328   CZ487086   CZ487087   EC062225   EC063406   EC068763   EC073128   EC084009   EC086738   EC220614   EC233555   EC245020   EC248030   EV584237   U35621 AAB82065
UniProtKB/Swiss-Prot	P54623
UniProtKB/TrEMBL	E1JH56 A1Z9D3 A1Z9D4
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) ventral ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 5     (Heuer et al., 1995) embryonic stage 6 -- 7   ventral furrow   (Heuer et al., 1995) cephalic furrow   (Heuer et al., 1995) embryonic stage 7 -- 8   ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) Comment:reported as ventral nerve cord anlage embryonic stage 9 -- 10   central brain primordium   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 10   neuroblast   (Heuer et al., 1995) embryonic stage 11   peripheral nervous system   (Heuer et al., 1995) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 16   visceral mesoderm | restricted   (Heuer et al., 1995) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) embryonic stage 14   central nervous system   (Heuer et al., 1995) brain   (Heuer et al., 1995) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Li et al., 1998) adult stage | male   testis   (Li et al., 1998) adult stage | female   ovary   (Li et al., 1998)
Additional Descriptive Data
	cnn transcripts are first detected at stage 5. High levels are present in gastrulating embryos along the ventral and cephalic furrows and later in the mesoderm. By stage 10, expression is seen in neuroblasts of the CNS, and by stage 11 in the PNS. By stage 14, expression is stronger in the thoracic part of the nerve cord than in the abdominal region and can be seen in the brain hemispheres as well. From stage 11-16, expression is observed in two domains of the visceral mesoderm surrounding the midgut. Double labeling shows that the anterior domain is located just anterior to cells expressing Scr and the posterior domain overlaps with cells expressing Antp and Ubx. (Heuer et al., 1995)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4     (Vaizel-Ohayon and Schejter, 1999) blastoderm embryo   • centriole | surrounding (Lecuyer et al., 2007) embryonic stage 5     (Heuer et al., 1995) embryonic stage 6 -- 7   ventral furrow   (Heuer et al., 1995) cephalic furrow   (Heuer et al., 1995) embryonic stage 10   neuroblast   (Heuer et al., 1995) embryonic stage 11   peripheral nervous system   (Heuer et al., 1995) embryonic stage 14   brain   (Heuer et al., 1995) central nervous system   (Heuer et al., 1995) embryonic stage 14 -- 16   visceral mesoderm of midgut constriction 2   (Heuer et al., 1995) visceral mesoderm of gastric caecum   (Heuer et al., 1995) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Li et al., 1998) adult stage | male   spermatogonium   (Li et al., 1998) testis   (Li et al., 1998) spermatocyte   (Li et al., 1998) adult stage & oogenesis   ovary   (Li et al., 1998) spermatogenesis & adult stage   testis   (Li et al., 1998)
Additional Descriptive Data
	cnn protein localizes to the centrosomes of the first zygotic nucleus. This centrosomal association persists throughout the 13 synchronous rounds of nuclear divisions of the syncytial embryo. During the syncytial divisions, cnn protein is found at all microtubule-organizing centers. The centrosome localization is not dependent on the presence of an intact microtubule cytoskeleton. (Vaizel-Ohayon and Schejter, 1999) cnn protein is expressed at high levels during both mitotic and meiotic divisions. It is closely associated with the centrosomes in a cell-dependent manner throughout spermatogenesis. During spermatogonial cell mitoses, cnn protein is strongly detected at spindle poles. At interphases it is present in centrosomes at much lower levels and is found at high levels in the cytoplasm. During the rapid growth phase of primary spermatocytes, cnn protein is in close association with the centriole. In each spermatocyte, two dots of cnn staining are seen at the membrane, representing the duplicated centrosomes. Later, as cells approach the meiotic divisions, the centrosomes migrate back to the nuclear membranes and higher levels of cnn protein staining are seen in the centrosomes. Accumulation of FBgn0013765:cnn protein in the spermatocyte centrosomes is not dependent on the presence of microtubules. FBgn0013765:cnn protein is detected in the centrosomes during both meiotic divisions. During meiosis II, there is a single centriole in each centrosome. In postmeiotic cells, the single centriole inserts into the nucleus and becomes the basal body. FBgn0013765:cnn@ protein is detected in the basal body until the early stages of axonemal elongation. (Li et al., 1998) The pattern of cnn protein distribution is essentially identical to that of cnn transcripts. Immunostaining demonstrates that there are more cells toward the ventral midline in the thoracic neuromeres that express cnn protein compared to the abdominal neuromeres. Furthermore, cnn protein and transcript expression patterns are not identical in the visceral mesoderm. cnn protein is not visible in the visceral mesoderm at late germ band retraction but is observed in stages 14-16 in the visceral mesoderm of the gastric caecae and the second midgut constriction. (Heuer et al., 1995)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
centriole inferred from direct assay (Blachon et al., 2009, Conduit and Raff, 2010) centrosome inferred from direct assay (Heuer et al., 1995, Li and Kaufman, 1996, Eisman et al., 2009) pericentriolar material inferred from direct assay (Blachon et al., 2009, Conduit et al., 2010, Dobbelaere et al., 2008) spindle pole inferred from direct assay (Eisman et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, adult ovary, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    372.475 Larval Midgut    28.5 Larval Hindgut    26 Larval Malpighian Tubules    5.9 Larval Fat Body    68.4 Larval Salivary Gland    19.3 Larval Trachea    28.15 Larval Carcass    81.775 Adult Head    84.5 Adult Eye    81.3 Adult Brain    255.4 Adult Thoracic-Abdominal Ganglion    267.5 Adult Crop    100.8 Adult Midgut    39.1 Adult Hindgut    70.9 Adult Malpighian Tubules    21.8 Adult Fat Body    62.8 Adult Salivary Gland    30.6 Adult Heart    77.85 Adult VirginFemale Spermatheca    99.2 Adult InseminatedFemale Spermatheca    77.3 Adult Ovary    304 Adult Testis    13.8 Adult Male Accessory Gland    22.9 Adult Carcass    115.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    372.475 Larval Midgut    28.5 Larval Hindgut    26 Larval Malpighian Tubules    5.9 Larval Fat Body    68.4 Larval Salivary Gland    19.3 Larval Trachea    28.15 Larval Carcass    81.775 Adult Head    84.5 Adult Eye    81.3 Adult Brain    255.4 Adult Thoracic-Abdominal Ganglion    267.5 Adult Crop    100.8 Adult Midgut    39.1 Adult Hindgut    70.9 Adult Malpighian Tubules    21.8 Adult Fat Body    62.8 Adult Salivary Gland    30.6 Adult Heart    77.85 Adult VirginFemale Spermatheca    99.2 Adult InseminatedFemale Spermatheca    77.3 Adult Ovary    304 Adult Testis    13.8 Adult Male Accessory Gland    22.9 Adult Carcass    115.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    372.475 Larval Midgut    28.5 Larval Hindgut    26 Larval Malpighian Tubules    5.9 Larval Fat Body    68.4 Larval Salivary Gland    19.3 Larval Trachea    28.15 Larval Carcass    81.775 Adult Head    84.5 Adult Eye    81.3 Adult Brain    255.4 Adult Thoracic-Abdominal Ganglion    267.5 Adult Crop    100.8 Adult Midgut    39.1 Adult Hindgut    70.9 Adult Malpighian Tubules    21.8 Adult Fat Body    62.8 Adult Salivary Gland    30.6 Adult Heart    77.85 Adult VirginFemale Spermatheca    99.2 Adult InseminatedFemale Spermatheca    77.3 Adult Ovary    304 Adult Testis    13.8 Adult Male Accessory Gland    22.9 Adult Carcass    115.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    372.475 Larval Midgut    28.5 Larval Hindgut    26 Larval Malpighian Tubules    5.9 Larval Fat Body    68.4 Larval Salivary Gland    19.3 Larval Trachea    28.15 Larval Carcass    81.775 Adult Head    84.5 Adult Eye    81.3 Adult Brain    255.4 Adult Thoracic-Abdominal Ganglion    267.5 Adult Crop    100.8 Adult Midgut    39.1 Adult Hindgut    70.9 Adult Malpighian Tubules    21.8 Adult Fat Body    62.8 Adult Salivary Gland    30.6 Adult Heart    77.85 Adult VirginFemale Spermatheca    99.2 Adult InseminatedFemale Spermatheca    77.3 Adult Ovary    304 Adult Testis    13.8 Adult Male Accessory Gland    22.9 Adult Carcass    115.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    372.475 Larval Midgut    28.5 Larval Hindgut    26 Larval Malpighian Tubules    5.9 Larval Fat Body    68.4 Larval Salivary Gland    19.3 Larval Trachea    28.15 Larval Carcass    81.775 Adult Head    84.5 Adult Eye    81.3 Adult Brain    255.4 Adult Thoracic-Abdominal Ganglion    267.5 Adult Crop    100.8 Adult Midgut    39.1 Adult Hindgut    70.9 Adult Malpighian Tubules    21.8 Adult Fat Body    62.8 Adult Salivary Gland    30.6 Adult Heart    77.85 Adult VirginFemale Spermatheca    99.2 Adult InseminatedFemale Spermatheca    77.3 Adult Ovary    304 Adult Testis    13.8 Adult Male Accessory Gland    22.9 Adult Carcass    115.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    372.475 Larval Midgut    28.5 Larval Hindgut    26 Larval Malpighian Tubules    5.9 Larval Fat Body    68.4 Larval Salivary Gland    19.3 Larval Trachea    28.15 Larval Carcass    81.775 Adult Head    84.5 Adult Eye    81.3 Adult Brain    255.4 Adult Thoracic-Abdominal Ganglion    267.5 Adult Crop    100.8 Adult Midgut    39.1 Adult Hindgut    70.9 Adult Malpighian Tubules    21.8 Adult Fat Body    62.8 Adult Salivary Gland    30.6 Adult Heart    77.85 Adult VirginFemale Spermatheca    99.2 Adult InseminatedFemale Spermatheca    77.3 Adult Ovary    304 Adult Testis    13.8 Adult Male Accessory Gland    22.9 Adult Carcass    115.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    372.475 Larval Midgut    28.5 Larval Hindgut    26 Larval Malpighian Tubules    5.9 Larval Fat Body    68.4 Larval Salivary Gland    19.3 Larval Trachea    28.15 Larval Carcass    81.775 Adult Head    84.5 Adult Eye    81.3 Adult Brain    255.4 Adult Thoracic-Abdominal Ganglion    267.5 Adult Crop    100.8 Adult Midgut    39.1 Adult Hindgut    70.9 Adult Malpighian Tubules    21.8 Adult Fat Body    62.8 Adult Salivary Gland    30.6 Adult Heart    77.85 Adult VirginFemale Spermatheca    99.2 Adult InseminatedFemale Spermatheca    77.3 Adult Ovary    304 Adult Testis    13.8 Adult Male Accessory Gland    22.9 Adult Carcass    115.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    372.475 Larval Midgut    28.5 Larval Hindgut    26 Larval Malpighian Tubules    5.9 Larval Fat Body    68.4 Larval Salivary Gland    19.3 Larval Trachea    28.15 Larval Carcass    81.775 Adult Head    84.5 Adult Eye    81.3 Adult Brain    255.4 Adult Thoracic-Abdominal Ganglion    267.5 Adult Crop    100.8 Adult Midgut    39.1 Adult Hindgut    70.9 Adult Malpighian Tubules    21.8 Adult Fat Body    62.8 Adult Salivary Gland    30.6 Adult Heart    77.85 Adult VirginFemale Spermatheca    99.2 Adult InseminatedFemale Spermatheca    77.3 Adult Ovary    304 Adult Testis    13.8 Adult Male Accessory Gland    22.9 Adult Carcass    115.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    84.5   NA  Eye    81.3   NA  Brain    255.4   372.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    267.5   NA  Crop    100.8   28.5  Midgut    39.1   26  Hindgut    70.9   5.9  Malpighian Tubules    no informative data   68.4  Fat Body    62.8   19.3  Salivary Gland    30.6   NA  Heart    77.85   28.15  Trachea    NA   NA  VirginFemale Spermatheca    99.2   NA  InseminatedFemale Spermatheca    77.3   NA  Ovary    304   NA  Testis    13.8   NA  Male Accessory Gland    22.9   81.775  Carcass    115.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    38 central nervous system, pupae P8    28 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    12 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    20 head, mated 4-day male    21 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    4 fat body, white prepupae    40 fat body, pupae P8    25 carcass, larvae L3 wandering    15 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female    66 ovary, mated 4-day female    54 testis, mated 4-day male    65 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (40) central nervous system, larvae L3  (38) central nervous system, pupae P8  (28) head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    12 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    20 head, mated 4-day male    21 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    4 fat body, white prepupae  (40) fat body, pupae P8    25 carcass, larvae L3 wandering    15 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female  (66) ovary, mated 4-day female  (54) testis, mated 4-day male  (65) accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    38 central nervous system, pupae P8    28 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    12 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    20 head, mated 4-day male    21 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    4 fat body, white prepupae    40 fat body, pupae P8    25 carcass, larvae L3 wandering    15 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female    66 ovary, mated 4-day female    54 testis, mated 4-day male    65 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    38 central nervous system, pupae P8    28 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    12 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    20 head, mated 4-day male    21 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    4 fat body, white prepupae    40 fat body, pupae P8    25 carcass, larvae L3 wandering    15 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female    66 ovary, mated 4-day female    54 testis, mated 4-day male    65 accessory gland, mated 4-day male    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    38 central nervous system, pupae P8    28 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    12 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    20 head, mated 4-day male    21 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    4 fat body, white prepupae    40 fat body, pupae P8    25 carcass, larvae L3 wandering    15 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female    66 ovary, mated 4-day female    54 testis, mated 4-day male    65 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (40) central nervous system, larvae L3  (38) central nervous system, pupae P8  28 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    12 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    20 head, mated 4-day male    21 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    4 fat body, white prepupae  (40) fat body, pupae P8    25 carcass, larvae L3 wandering    15 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female  (66) ovary, mated 4-day female  (54) testis, mated 4-day male  (65) accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    38 central nervous system, pupae P8    28 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    12 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    20 head, mated 4-day male    21 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    4 fat body, white prepupae    40 fat body, pupae P8    25 carcass, larvae L3 wandering    15 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female    66 ovary, mated 4-day female    54 testis, mated 4-day male    65 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    40 central nervous system, larvae L3    38 central nervous system, pupae P8    28 head, virgin 1-day female    15 head, virgin 4-day female    15 head, virgin 20-day female    12 head, mated 1-day female    13 head, mated 4-day female    13 head, mated 20-day female    11 head, mated 1-day male    20 head, mated 4-day male    21 head, mated 20-day male    21 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    9 digestive system, 1-day adult    2 digestive system, 4-day adult    4 digestive system, 20-day adult    3 fat body, larvae L3 wandering    4 fat body, white prepupae    40 fat body, pupae P8    25 carcass, larvae L3 wandering    15 carcass, 1-day adult    15 carcass, 4-day adult    16 carcass, 20-day adult    11 ovary, virgin 4-day female    66 ovary, mated 4-day female    54 testis, mated 4-day male    65 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    53 embryo 04-06hr    56 embryo 06-08hr    54 embryo 08-10hr    57 embryo 10-12hr    31 embryo 12-14hr    31 embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    6 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    19 white prepupae new    25 white prepupae 12hr    34 white prepupae 24hr    36 pupae 2d postWPP    33 pupae 3d postWPP    42 pupae 4d postWPP    26 adult male 01day    33 adult male 05day    42 adult male 30day    37 adult female 01day    15 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (41) embryo 02-04hr  (53) embryo 04-06hr  (56) embryo 06-08hr  (54) embryo 08-10hr  (57) embryo 10-12hr  (31) embryo 12-14hr  (31) embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    6 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    19 white prepupae new    25 white prepupae 12hr  (34) white prepupae 24hr  (36) pupae 2d postWPP  (33) pupae 3d postWPP  (42) pupae 4d postWPP  26 adult male 01day  (33) adult male 05day  (42) adult male 30day  (37) adult female 01day    15 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    53 embryo 04-06hr    56 embryo 06-08hr    54 embryo 08-10hr    57 embryo 10-12hr    31 embryo 12-14hr    31 embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    6 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    19 white prepupae new    25 white prepupae 12hr    34 white prepupae 24hr    36 pupae 2d postWPP    33 pupae 3d postWPP    42 pupae 4d postWPP    26 adult male 01day    33 adult male 05day    42 adult male 30day    37 adult female 01day    15 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    53 embryo 04-06hr    56 embryo 06-08hr    54 embryo 08-10hr    57 embryo 10-12hr    31 embryo 12-14hr    31 embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    6 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    19 white prepupae new    25 white prepupae 12hr    34 white prepupae 24hr    36 pupae 2d postWPP    33 pupae 3d postWPP    42 pupae 4d postWPP    26 adult male 01day    33 adult male 05day    42 adult male 30day    37 adult female 01day    15 adult female 05day    24 adult female 30day    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    53 embryo 04-06hr    56 embryo 06-08hr    54 embryo 08-10hr    57 embryo 10-12hr    31 embryo 12-14hr    31 embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    6 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    19 white prepupae new    25 white prepupae 12hr    34 white prepupae 24hr    36 pupae 2d postWPP    33 pupae 3d postWPP    42 pupae 4d postWPP    26 adult male 01day    33 adult male 05day    42 adult male 30day    37 adult female 01day    15 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (41) embryo 02-04hr  (53) embryo 04-06hr  (56) embryo 06-08hr  (54) embryo 08-10hr  (57) embryo 10-12hr  31 embryo 12-14hr  31 embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    6 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    19 white prepupae new    25 white prepupae 12hr  (34) white prepupae 24hr  (36) pupae 2d postWPP  (33) pupae 3d postWPP  (42) pupae 4d postWPP  26 adult male 01day  (33) adult male 05day  (42) adult male 30day  (37) adult female 01day    15 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    53 embryo 04-06hr    56 embryo 06-08hr    54 embryo 08-10hr    57 embryo 10-12hr    31 embryo 12-14hr    31 embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    6 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    19 white prepupae new    25 white prepupae 12hr    34 white prepupae 24hr    36 pupae 2d postWPP    33 pupae 3d postWPP    42 pupae 4d postWPP    26 adult male 01day    33 adult male 05day    42 adult male 30day    37 adult female 01day    15 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    53 embryo 04-06hr    56 embryo 06-08hr    54 embryo 08-10hr    57 embryo 10-12hr    31 embryo 12-14hr    31 embryo 14-16hr    19 embryo 16-18hr    20 embryo 18-20hr    15 embryo 20-22hr    17 embryo 22-24hr    19 larva L1    6 larva L2    3 larva L3 12hr old    3 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    12 larva L3 puffstage 7-9    19 white prepupae new    25 white prepupae 12hr    34 white prepupae 24hr    36 pupae 2d postWPP    33 pupae 3d postWPP    42 pupae 4d postWPP    26 adult male 01day    33 adult male 05day    42 adult male 30day    37 adult female 01day    15 adult female 05day    24 adult female 30day    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    14 embryonic 1182-4H    55 embryonic GM2    85 embryonic Kc167    98 embryonic S1    36 embryonic S3    42 leg disc CME L1    25 wing disc CME-W2    41 wing disc ML-DmD8    42 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    36 wing disc ML-DmD21    12 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    149 ovary fGS/OSS    30 ovary OSC    27 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (71) Schneider line 2 Sg4    14 embryonic 1182-4H  (55) embryonic GM2  (85) embryonic Kc167  (98) embryonic S1  (36) embryonic S3  (42) leg disc CME L1    25 wing disc CME-W2  (41) wing disc ML-DmD8  (42) wing disc ML-DmD9  (29) wing disc ML-DmD16-c3  (36) wing disc ML-DmD21    12 wing disc ML-DmD32  26 haltere disc ML-DmD17-c3  (28) eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1  (30) CNS ML-DmBG1-c1  (35) CNS ML-DmBG2-c2  (69) tumorous blood cells mbn2  (149) ovary fGS/OSS  (30) ovary OSC  (27) ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    14 embryonic 1182-4H    55 embryonic GM2    85 embryonic Kc167    98 embryonic S1    36 embryonic S3    42 leg disc CME L1    25 wing disc CME-W2    41 wing disc ML-DmD8    42 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    36 wing disc ML-DmD21    12 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2  (149) ovary fGS/OSS    30 ovary OSC    27 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    14 embryonic 1182-4H    55 embryonic GM2    85 embryonic Kc167    98 embryonic S1    36 embryonic S3    42 leg disc CME L1    25 wing disc CME-W2    41 wing disc ML-DmD8    42 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    36 wing disc ML-DmD21    12 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    149 ovary fGS/OSS    30 ovary OSC    27 ovary OSS    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    14 embryonic 1182-4H    55 embryonic GM2    85 embryonic Kc167    98 embryonic S1    36 embryonic S3    42 leg disc CME L1    25 wing disc CME-W2    41 wing disc ML-DmD8    42 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    36 wing disc ML-DmD21    12 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    149 ovary fGS/OSS    30 ovary OSC    27 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (71) Schneider line 2 Sg4    14 embryonic 1182-4H  (55) embryonic GM2  (85) embryonic Kc167  (98) embryonic S1  (36) embryonic S3  (42) leg disc CME L1    25 wing disc CME-W2  (41) wing disc ML-DmD8  (42) wing disc ML-DmD9  29 wing disc ML-DmD16-c3  (36) wing disc ML-DmD21    12 wing disc ML-DmD32  26 haltere disc ML-DmD17-c3  28 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1  30 CNS ML-DmBG1-c1  (35) CNS ML-DmBG2-c2  (69) tumorous blood cells mbn2  (149) ovary fGS/OSS  30 ovary OSC  27 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    14 embryonic 1182-4H    55 embryonic GM2    85 embryonic Kc167    98 embryonic S1    36 embryonic S3    42 leg disc CME L1    25 wing disc CME-W2    41 wing disc ML-DmD8    42 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    36 wing disc ML-DmD21    12 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2  (149) ovary fGS/OSS    30 ovary OSC    27 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    71 Schneider line 2 Sg4    14 embryonic 1182-4H    55 embryonic GM2    85 embryonic Kc167    98 embryonic S1    36 embryonic S3    42 leg disc CME L1    25 wing disc CME-W2    41 wing disc ML-DmD8    42 wing disc ML-DmD9    29 wing disc ML-DmD16-c3    36 wing disc ML-DmD21    12 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    28 eye-antennal disc ML-DmD11    19 antennal disc ML-DmD20-c5    11 mixed discs ML-DmD4-c1    30 CNS ML-DmBG1-c1    35 CNS ML-DmBG2-c2    69 tumorous blood cells mbn2    149 ovary fGS/OSS    30 ovary OSC    27 ovary OSS    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    51 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult  (51) Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  (41) Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3  (41) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (37) Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult  (37) Paraquat 10 mM 48 hrs, 4-day adult  (40) Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    51 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    51 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    51 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult  (51) Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult  (41) Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult  26 Ethanol 2.5% 3 hrs, larvae L3  (41) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (37) Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult  (37) Paraquat 10 mM 48 hrs, 4-day adult  (40) Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    51 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    14 heat shock, 4-day adult    18 Cadmium 50 mM 6 hrs, larvae L3    4 Cadmium 50 mM 12 hrs, larvae L3    7 Cadmium 50 mM 48 hrs, 4-day adult    20 Cadmium 100 mM 48 hrs, 4-day adult    51 Copper 0.5 mM 12 hrs, larvae L3    4 Copper 15 mM 48 hrs, 4-day adult    41 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    26 Ethanol 2.5% 3 hrs, larvae L3    41 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    15 Paraquat 5 mM 48 hrs, 4-day adult    37 Paraquat 10 mM 48 hrs, 4-day adult    40 Rotenone 2 μg 12 hrs, larvae L3    5 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_21 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD19135 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013765 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4832-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage cnnHK21 cnnmfs3 cnnmfs7 lethal | embryonic stage | maternal effect, with Scer\GAL4nos.UTR.T:Hsim\VP16 cnnΔ1.Scer\UAS.T:Avic\GFP-EGFP lethal | embryonic stage | maternal effect (with cnn25cn1) cnnHK21 lethal | embryonic stage | maternal effect (with cnnHK21) cnn25cn1 lethal | embryonic stage | maternal effect | recessive cnnHK21 cnnmfs1 cnnmfs2 cnnmfs3 cnnmfs7 cnnmfs8 lethal | maternal effect cnn25cn1 cnnScim partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 cnnGD1726 viable cnn25cn1 cnnB4 cnnE2 cnnEY05872 cnnHK21 cnnmfs1 cnnmfs2 cnnmfs3 cnnmfs7 cnnmfs8 cnnScim Sterility Allele female sterile cnnB4 cnnE2 cnnHK21 cnnmfs1 cnnmfs2 cnnmfs3 female sterile | recessive cnnHK21 cnnmfs1 cnnmfs2 cnnmfs3 cnnmfs7 cnnmfs8 fertile cnnEY05872 male fertile cnnScim male sterile cnn25cn1 cnnB4 cnnE2 cnnHK21 cnnmfs1 cnnmfs2 cnnmfs3 male sterile | recessive cnnHK21 cnnmfs1 cnnmfs2 cnnmfs3 cnnmfs7 cnnmfs8 Other Phenotypes Allele cell cycle defective cnnHK21 cytokinesis defective | male (with Df(2R)cnn) cnnmfs1 cnnmfs2 cnnmfs3 meiotic cell cycle defective | dominant cnnScim mitotic cell cycle defective cnnHK21 cnnmfs3 cnnmfs7 wild-type cnn+mVa cnn+t16 cnnotu.PV Phenotype manifest in Allele astral microtubule cnnWT.Act5C.T:Ivir\HA1 axoneme cnnmfs1 centriolar satellite, with Scer\GAL4nos.UTR.T:Hsim\VP16 cnnΔ1.Scer\UAS.T:Avic\GFP-EGFP centriole cnnHK21 cnnf04547 centrosome cnnHK21 cnndsRNA.cMa centrosome, with Scer\GAL4nos.UTR.T:Hsim\VP16 cnnΔ1.Scer\UAS.T:Avic\GFP-EGFP centrosome & male germline stem cell cnnHK21 centrosome | embryonic stage 4 cnnE2 cnnHK21 cleavage furrow | embryonic stage cnnB4 cyst progenitor cell (with cnnHK21) cnnmfs3 cyst progenitor cell (with cnnmfs3) cnnHK21 embryo cnnE2 cnnHK21 embryo | maternal effect cnnHK21 cnnmfs1 cnnmfs2 cnnmfs3 cnnmfs7 cnnmfs8 embryonic cortex & actin filament cnnB4 cnnE2 cnnHK21 ganglion mother cell | somatic clone cnnHK21 male germline stem cell & centrosome cnnHK21 male germline stem cell & spindle cnnHK21 male germline stem cell | supernumerary cnnHK21 male germline stem cell | supernumerary (with cnnHK21) cnnmfs3 male germline stem cell | supernumerary (with cnnmfs3) cnnHK21 meiosis I & aster cnnmfs1 cnnmfs2 meiotic cell cycle | male cnnmfs1 cnnmfs2 cnnmfs3 mitotic cell cycle cnnHK21 cnndsRNA.cMa neuroblast cnnHK21 neuroblast | somatic clone | supernumerary cnnHK21 neuroblast | supernumerary cnnHK21 nuclear chromosome | embryonic stage | maternal effect cnnmfs1 cnnmfs7 cnnmfs8 nucleus | embryonic stage | maternal effect cnnmfs1 cnnmfs2 cnnmfs3 cnnmfs7 cnnmfs8 pericentriolar material | embryonic stage 4 cnnE2 cnnHK21 pole cell cnnHK21 pole cell | maternal effect cnnHK21 spermatid cnnHK21 cnnmfs1 cnnmfs2 cnnmfs3 spermatocyte cnnmfs2 spermatocyte & spindle cnnmfs1 spindle cnnHK21 cnndsRNA.cMa cnnmfs3 cnnmfs7 cnndsRNA.cMb spindle (with cnnHK21) cnnmfs3 spindle (with cnnmfs3) cnnHK21 spindle | embryonic stage cnnB4 cnnHK21 spindle | embryonic stage 4 cnnE2 cnnHK21 spindle | embryonic stage | maternal effect cnnmfs7 cnnmfs8 spindle microtubule cnndsRNA.cMa wing cnnHK21
Classical Alleles ( 17 )
For All Classical Alleles Show
Allele of cnn Class Mutagen Stocks Known lesion cnnHK21 ethyl methanesulfonate 2 Yes cnnd08390 P-element activity 1 -- cnne00441 piggyBac transposase 1 -- cnnEY05872 P-element activity 1 -- cnnf04547 piggyBac transposase 1 -- cnnKG05783 P-element activity 1 -- cnnmfs3 ethyl methanesulfonate 1 Yes cnnmfs7 ethyl methanesulfonate 1 Yes cnn25cn1 P-element activity 0 Yes cnn8-104 P-element activity 0 Yes cnnB4 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes cnnE2 ethyl methanesulfonate 0 Yes cnnmfs1 ethyl methanesulfonate 0 -- cnnmfs2 ethyl methanesulfonate 0 Yes cnnmfs8 ethyl methanesulfonate 0 Yes cnnScim Delta2-3 0 Yes cnnunspecified 0 --
Alleles Carried on Transgenic Constructs ( 21 )
For All Alleles Carried on Transgenic Constructs Show
Allele of cnn Class Mutagen Stocks Known lesion cnnGD1726 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cnnHMS01509 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cnnJF01769 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes cnnScer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 1 Yes cnn+mVa in vitro construct - minigene 0 Yes cnn+t16 in vitro construct - genomic fragment 0 Yes cnndsRNA.cMa in vitro construct - RNAi 0 Yes cnndsRNA.cMb in vitro construct - RNAi 0 -- cnndsRNA.cTa in vitro construct - RNAi 0 Yes cnnhs.PL in vitro construct - regulatory fusion 0 Yes cnnKK101523 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cnnNIG.4832R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes cnnotu.PV in vitro construct - regulatory fusion 0 Yes cnnPA.Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cnnPA.Ubi-p63E.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cnnPG.Scer\UAS.P\T.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cnnUbi-p63E.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cnnUbi-p63E.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cnnWT.Act5C.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes cnnWT.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes cnnΔ1.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Partially disrupted in	Df(2R)cnn25cn1 (Zhang and Megraw, 2007)
Disrupted in	Df(2R)8-104 (Vaizel-Ohayon and Schejter, 1999) Df(2R)AA1 (Vaizel-Ohayon and Schejter, 1999) Df(2R)BSC273 (Christensen and Cook, 2007.3.22) Df(2R)BSC274 (Christensen and Cook, 2007.3.22) Df(2R)BSC306 (Christensen and Cook, 2007.5.8) Df(2R)cnn (Megraw et al., 2002, Li and Kaufman, 1996) Df(2R)CX1 (Vaizel-Ohayon and Schejter, 1999)
Not disrupted in	Df(2R)MK1 (Vaizel-Ohayon and Schejter, 1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1726} NA P{KK101523} NA P{NIG.4832R} NA P{TRiP.HMS01509} NA P{TRiP.JF01769} NA P{UASp-cnn.WT} NA P{UASp-cnn.Δ1} NA P{UASp-GFP-Cnn1} NA P{UASp-GFP-cnn.PA} NA P{UASp-GFP-cnn.PG} NA heat-shock construct P{hs-cnn.L} NA characterization construct P{cnn+mVa} NA P{cnn+t16} NA P{otu-cnn.V} NA P{Ubi-p63E-cnn.GFP} NA P{Ubi-p63E-cnn.PA.GFP} NA P{Ubi-p63E-cnn.RFP} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG42321EP2268 NA P{EPgy2}cnnEY05872 NA P{XP}cnnd08390 NA miscellaneous insertions P{SUPor-P}cnnKG05783 NA P{SUPor-P}cnnScim NA PBac{RB}cnne00441 NA PBac{WH}cnnf04547 NA
Gene Ontology: Function, Process & Cellular Component ( 26 unique terms )
Terms Based on Experimental Evidence ( 19 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Cen (Kao and Megraw, 2009)
Biological Process
CV term Evidence References
asymmetric cell division inferred from direct assay (Lucas and Raff, 2007) asymmetric neuroblast division inferred from mutant phenotype (Cabernard and Doe, 2009) central nervous system development inferred from mutant phenotype (Heuer et al., 1995) centriole replication inferred from direct assay (Lucas and Raff, 2007) centrosome cycle inferred from mutant phenotype (Megraw et al., 1999) centrosome organization inferred from mutant phenotype (Blachon et al., 2009, Müller et al., 2010, Dobbelaere et al., 2008) embryonic cleavage inferred from mutant phenotype (Kao and Megraw, 2009, Eisman et al., 2009) female meiosis chromosome segregation inferred from mutant phenotype (Dobie et al., 2001) midgut development inferred from mutant phenotype (Heuer et al., 1995) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) peripheral nervous system development inferred from mutant phenotype (Heuer et al., 1995) photoreceptor cell morphogenesis inferred from mutant phenotype (Chen et al., 2011) pole cell formation inferred from mutant phenotype (Lerit and Gavis, 2011) regulation of centriole-centriole cohesion inferred from mutant phenotype (Conduit and Raff, 2010)
Cellular Component
CV term Evidence References
centriole inferred from direct assay (Blachon et al., 2009, Conduit and Raff, 2010) centrosome inferred from direct assay (Heuer et al., 1995, Li and Kaufman, 1996, Eisman et al., 2009) pericentriolar material inferred from direct assay (Blachon et al., 2009, Conduit et al., 2010, Dobbelaere et al., 2008) spindle pole inferred from direct assay (Eisman et al., 2009)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
microtubule binding inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Biological Process
CV term Evidence References
microtubule-based process inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) microtubule cytoskeleton organization non-traceable author statement (Li et al., 1995) mitotic spindle organization non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) nuclear division non-traceable author statement (Schejter et al., 1997)
Cellular Component
CV term Evidence References
centrosome non-traceable author statement (Li et al., 1995, Li, 1995.9.7, Swiss-Prot Project Members, 1996.10.1) cytoplasm non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) microtubule associated complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) myosin complex inferred from sequence or structural similarity with EMBL:D85924 (FlyBase, 1992-) pericentriolar material non-traceable author statement (Gonzalez and Bornens, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
cnn - Cen two hybrid (Kao and Megraw, 2009) cnn - mael anti bait coimmunoprecipitation, peptide massfingerprinting, western blot, genetic interference (Sato et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions cnn allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62251 DroID - A comprehensive database of gene and protein interactions. • FBgn0013765 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36491
Orthologs
OrthoDB Orthologs (29) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6CNR9G Dipteran inclusive ortholog search EOG6MPHZ3 Insect inclusive ortholog search EOG69S525 Arthropod inclusive ortholog search EOG6DFN3C Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6CNR9G)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\cnn     Drosophila simulans   Dsim\GD25761 Y   Drosophila sechellia   Dsec\GM20278 Y   Drosophila erecta   Dere\GG22491 Y   Drosophila yakuba   Dyak\GE13363 Y   Drosophila ananassae   Dana\GF11185 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18464 Y   Drosophila persimilis   Dper\GL17401 Y   Drosophila willistoni   Dwil\GK10742 Y   Drosophila virilis   Dvir\GJ21311 Y   Drosophila mojavensis   Dmoj\GI18938 Y   Drosophila grimshawi   Dgri\GH23115 Y
Orthologs in non-Drosophila Dipterans (EOG6MPHZ3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008110   Anopheles gambiae Malaria mosquito  Agam\AGAP002434   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011971   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011593
Orthologs in non-Dipteran Insects (EOG69S525)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45937   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG002605   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH27233   Atta cephalotes Leafcutter ant  Acep\ACEP12051   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13444   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL18354   Linepithema humile Argentine ant  Lhum\LH20338   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15943   Solenopsis invicta Red fire ant  Sinv\SINV21498   Pediculus humanus Human body louse  Phum\PHUM248490   Tribolium castaneum Red flour beetle  Tcas\cnn
Orthologs in non-Insect Arthropods (EOG6DFN3C)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\rps3   Daphnia pulex Water flea  Dpux\dsrA
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25761 Drosophila sechellia Dsec\GM20278 Drosophila erecta Dere\GG22491 Drosophila yakuba Dyak\GE13363 Drosophila ananassae Dana\GF11185 Drosophila pseudoobscura pseudoobscura Dpse\GA18464 Drosophila persimilis Dper\GL17401 Drosophila willistoni Dwil\GK10742 Drosophila virilis Dvir\GJ21311 Drosophila mojavensis Dmoj\GI18938 Drosophila grimshawi Dgri\GH23115
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	7255 P{UASp-GFP-Cnn1}26-1, w1118 27626 w1118; cnnmfs3/SM5 31402 y1 v1; P{TRiP.JF01769}attP2 16372 y1 w67c23; P{EPgy2}cnnEY05872 15101 y1; P{SUPor-P}cnnKG05783/CyO; ry506 5039 cn1 cnnHK21 bw1/CyO, l(2)DTS5131 28994 w*; cnnmfs7/CyO, P{GAL4-twi.G}2.2, P{UAS-2xEGFP}AH2.2
Harvard	- P{XP}cnnd08390 - PBac{RB}cnne00441 - PBac{WH}cnnf04547
Kyoto	108003 cn1 cnnHK21 bw1/CyO, l(2)DTS5131
VDRC	v44526 w1118 P{GD1726}v44526
	More stocks available...
Genomic Clones ( 1 )
	BACR48I15 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 71 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT07266 AT09084 LD19135 RE46972
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01813 AT02338 AT03776 AT06305 AT07160 AT08521 AT10189 AT11012 AT16195 AT16554 AT16926 AT21245 AT24444 AT24876 AT25401 AT27480 AT28678 AT28679 AT29110 AT29219 AT30815 GH07641 GM10056 LD03949 LD08081 LD16671 LD16681 LD19605 LD29704 LD30874 LD33662 LD36629 LD43584 LD47340 LP02441 RE08403 RE15692 RE25168 RE28008 RE29006 RE39261 RE53212 RE68819 RE75148
Other clones	5060 16502 35632 37465 37544 48444 67052 74276 99684 bs02e12 bs12c07 bs18c07 bs30g05 CK01.14D.F5 Dmel_dig_004791_0684_0993 EK045304 EK107742 EK124013 EK146250 EK172849 EK194937 EK203841 EK222343
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0013765 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36491
Antibody Information
	polyclonal (Vaizel-Ohayon and Schejter, 1999, Heuer et al., 1995, Eisman et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: cnn CG18370 (FlyBase, 1996-) Source for merge of: cnn mat(2)syn-C (Megraw et al., 1999) Source for merge of: cnn oblivious (Vaizel-Ohayon and Schejter, 1999)
Additional comments	Source for merge of cnn CG18370 was sequence comparison (date:001104). (FlyBase, 1996-)
Other Comments
	cnn is required for efficient recruitment of pericentriolar material. (Dobbelaere et al., 2008) Gene expression is increased in response to the presence of either one or two copies of Scer\GAL4hs.PB. (Liu and Lehmann, 2008) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes decreased γ-tubulin staining at the spindle pole when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) SL2 cells treated with dsRNA against cnn do not show a significant difference in the mitotic index compared to control cells. The treated cells show anastral bipolar spindle arrangements, with anastral poles that are often barrel-shaped and unfocused, however in spite of these abnormalities, anaphase progresses normally in these cells without and increase in abnormal chromosome arrangement compared to control cells. (Muller et al., 2006) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Transcription start sites of cnn and cbs are separated by a mere 134bp. Overall orientation not stated: cnn- cbs+ (Megraw, 1999.3.3) cnn is required for the assembly and function of centrosomes during the syncytial cleavage divisions in the embryo. (Megraw et al., 1999) cnn is an essential core component of early embryonic centrosomes. (Vaizel-Ohayon and Schejter, 1999) cnn is required for spindle organisation during male meiosis and for organisation of the sperm axoneme. (Li et al., 1998) Maternal effect mutations at the cnn locus prevent the correct restructuring of cortical microfilaments in the early embryo. (Schejter et al., 1997) cnn function is required for synchronous nuclear divisions in the early embryo, and for various morphological processes in the female and male germlines. (Schejter et al., 1997) Protein product associated with centrosomes during blastoderm cell cycles and then with centrosomes of mitotic cells. (Li and Kaufman, 1996) cnn exists as a monomer in the cytoplasm and is phosphorylated. (Li and Kaufman, 1996) cnn is an essential component of the centrosome, it is localised to the centrosome independent of microtubules. Postblastoderm stage cnn localisation and localisation during spermatogenesis and oogenesis is cell-cycle-dependent. (Li and Kaufman, 1996) Identified by immunopurification as a target gene for Antp. cnn encodes a centrosomal protein, may be involved in the assembly of mitotic spindles and maps to a genomic region required for midgut morphogenesis. (Heuer et al., 1995) Identification: cnn was identified in a screen for genomic DNA bound by homeotic proteins. (Li et al., 1995) Genetic, cell biological and biochemical data suggest that the cnn product controls morphogenesis through mediating microtubule organization and is homeotically regulated. (Li et al., 1995) Mutation in cnn results in a maternal effect phenotype with defects during syncytial blastoderm formation. (Schupbach and Wieschaus, 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057736 NM_165990 NM_165991 NM_001014523 NM_001038855 NM_001169670 NM_001259362 NM_001259363 NM_001259364 NM_001259365 NM_001259366 NM_001259367 RefSeq (Proteins) • NP_477084 NP_725297 NP_725298 NP_001014523 NP_001033944 NP_001163141 NP_001246291 NP_001246292 NP_001246293 NP_001246294 NP_001246295 NP_001246296 DDBJ / EMBL / GenBank • AA539856 AAB82065 AAF58375 AAF58375.1 AAF58376 AAF58376.2 AAM68579 AAM68579.1 AAN71043 AAQ22522 AAX33417 AAX52706 ABC66061 AC006488 AC007452 ACZ94414 AFH08045 AFH08046 AFH08047 AFH08048 AFH08049 AFH08050 AI259106 AI511992 AI944609 AI945384 AI945914 AI946795 AW942518 BF505100 BF506566 BI362423 BT001287 BT010053 BT021269 BZ665588 CL527835 CZ476209 CZ478328 CZ487086 CZ487087 U35621 Entrez Gene - A searchable database of RefSeq genes. • 36491 UniProtKB/Swiss-Prot • P54623 UniProtKB/TrEMBL • A1Z9D3 A1Z9D4 E1JH56
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Spindle associated (IPR012943) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD19135
Linkouts
	BioGRID - A database of protein and genetic interactions • 62251 DroID - A comprehensive database of gene and protein interactions. • FBgn0013765 DRSC - Results from RNAi screens. • FBgn0013765 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013765 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4832-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0013765 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36491 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/centrosomin1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36491 modMine - Data generated by the modENCODE project. • FBgn0013765
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	cen (Emery et al., 2005) CG4832 (Rebollo et al., 2004, Goldstein and Gunawardena, 2000, Goshima et al., 2007, Dobbelaere et al., 2008, Ni et al., 2008, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) CG 4832 (M Mahoney, 2006) CG18370   cnn (Muller et al., 2006, Mahoney et al., 2006, Nystul and Spradling, 2006, Christensen and Cook, 2007.3.22, Christensen and Cook, 2007.3.22, Christensen and Cook, 2007.5.8, Taniguchi et al., 2011, Cabernard et al., 2007, Brunk et al., 2007, Yamashita et al., 2007, Yamashita et al., 2007, Eisman et al., 2006, Lee et al., 2006, Megraw et al., 2008, Bakal et al., 2007, Yamashita et al., 2005, Gan et al., 2010, Colombie et al., 2006, Liu and Lehmann, 2008, Georlette et al., 2007, Riparbelli et al., 2007, Inaba et al., 2010, Somma et al., 2008, Moutinho-Pereira et al., 2010, Sato et al., 2011, Lucas and Raff, 2007, Slack et al., 2007, Zhang and Megraw, 2007, Siller and Doe, 2008, Egger et al., 2007, Doheny et al., 2008, Raynaud-Messina et al., 2004, Buffin et al., 2007, Riparbelli and Callaini, 2005, Castellanos et al., 2008, Rickmyre et al., 2007, Wei et al., 2008, Blachon et al., 2008, Brunk et al., 2007, Meireles et al., 2009, Wertheim et al., 2011, Cabernard and Doe, 2009, Wainman et al., 2009, Eisman et al., 2009, Giansanti et al., 2008, Rahmani et al., 2009, Buffin and Gho, 2010, Blachon et al., 2009, Chen et al., 2011, Conduit et al., 2010, Conduit and Raff, 2010, Riparbelli and Callaini, 2010, Cheng et al., 2011, Lerit and Gavis, 2011, Kao and Megraw, 2009, Cunha et al., 2010, Gopalakrishnan et al., 2011, Taniguchi et al., 2011, Habermann et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Sanghavi et al., 2012, Tao et al., 2012) CNN (Chodagam et al., 2005, Butcher et al., 2004, Yu et al., 2003, Lin, 2003, Cha et al., 2002, Lemos et al., 2000, Moritz et al., 1998, Wang et al., 2006, Rodrigues-Martins et al., 2007, Lecuyer et al., 2007, Martins et al., 2010, Tanentzapf et al., 2007, Basto et al., 2007, Martins et al., 2009, Brust-Mascher et al., 2009, Yang et al., 2005, Anderson et al., 2009, Rath et al., 2009, Wang et al., 2011, Li et al., 2010, Kotadia et al., 2008, Rodrigues-Martins et al., 2008) Cnn (Riggs et al., 2003, Megraw et al., 2001, Li, 1995.9.7, Li et al., 1998, Li et al., 1995, Verollet et al., 2006, Richter et al., 2011, Dix and Raff, 2007, Basto et al., 2006, Goshima et al., 2007, Maiato et al., 2006, Schneider et al., 2006, Mottier et al., 2008, Eisman et al., 2008, Hutterer et al., 2006, Varmark et al., 2007, Yamashita et al., 2005, Blagden and Glover, 2003, Siller et al., 2005, Bonaccorsi et al., 2007, Krahn et al., 2009, Cho et al., 2011, Moutinho-Pereira et al., 2009, Szafer-Glusman et al., 2011, Rusan and Peifer, 2007, Maurange et al., 2008, Bowman et al., 2006, Goshima et al., 2008, Rebollo et al., 2007, Giansanti et al., 2007, Dobbelaere et al., 2008, Pandey et al., 2007, Zhang et al., 2009, Rogers et al., 2008, Dix and Raff, 2007, Slack et al., 2006, Pimenta-Marques et al., 2008, Peel et al., 2007, Mottier-Pavie and Megraw, 2009, Sheng et al., 2009, Rebollo et al., 2009, Vale et al., 2009, Stevens et al., 2009, Robinett et al., 2009, Bucciarelli et al., 2009, Godin et al., 2010, Fabian et al., 2010, Van Damme et al., 2011, Mottier-Pavie et al., 2011, Rodrigues-Martins et al., 2008, Reschen et al., 2012, Basto et al., 2008, Gopalakrishnan et al., 2012, Guilgur et al., 2012, Sabino et al., 2011) Cnn1 (Bechstedt et al., 2010) mat(2)syn-C (Schupbach, 1992, ) mat(2)synHK21 (Schupbach and Wieschaus, 1989) mfs   obv (Vaizel-Ohayon and Schejter, 1999, )
Name Synonym	Centrosmin (Jankovics and Brunner, 2006) Centrosomin (Rusan and Peifer, 2007, Abdu et al., 2006, Basto et al., 2006, Mottier et al., 2008, Holtzman et al., 2008, Eisman et al., 2008, Yamashita et al., 2005, Siller et al., 2005, Bonaccorsi et al., 2007, Somma et al., 2008, Bowman et al., 2006, Rebollo et al., 2007, Zhang and Megraw, 2007, Riparbelli and Callaini, 2005, Pandey et al., 2007, Merkle et al., 2009, Rogers et al., 2008, Pimenta-Marques et al., 2008, Sheng et al., 2009, Rebollo et al., 2009, Stevens et al., 2009, Robinett et al., 2009, Blachon et al., 2009, Leatherman and Dinardo, 2010, Godin et al., 2010, Van Damme et al., 2011, Guilgur et al., 2012, Sabino et al., 2011) centrosomin (Pearson et al., 2005, Verollet et al., 2006, Goshima et al., 2007, Deshpande et al., 2006, McHugh et al., 2004, Hoopfer et al., 2008, Payne and Braun, 2006, Riparbelli et al., 2007, Cho et al., 2011, Moutinho-Pereira et al., 2010, Lucas and Raff, 2007, Goshima et al., 2008, Slack et al., 2007, Siller and Doe, 2008, Raynaud-Messina et al., 2004, Giansanti et al., 2008, Buffin et al., 2007, Tanentzapf et al., 2007, Rickmyre et al., 2007, Szalontai et al., 2009, Brunk et al., 2007, Meireles et al., 2009, Wainman et al., 2009, Yang et al., 2005, Cabernard and Doe, 2009, Wainman et al., 2009, Eisman et al., 2009, Vale et al., 2009, Rahmani et al., 2009, Rath et al., 2009, Buffin and Gho, 2010, Chen et al., 2011, Fabian et al., 2010, Conduit et al., 2010, Conduit and Raff, 2010, Kotadia et al., 2008, Cheng et al., 2011, Lerit and Gavis, 2011, Kao and Megraw, 2009, Rodrigues-Martins et al., 2008) maternal effect syncytial blastoderm arrest C   oblivious (Vaizel-Ohayon and Schejter, 1999, Schejter et al., 1997, )
Secondary FlyBase IDs
	FBgn0002675 FBgn0020264 FBgn0033839
References ( 293 )
Generate a list of	All references relating to this gene ( 293 )
List References by type	Research paper  ( 193 ) Supplementary material  ( 15 ) Review  ( 20 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 40 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Conference report  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 24 )
	Fu and Glover, 2012, Open Biol. 2(8): 120104 Structured illumination of the interface between centriole and peri-centriolar material. [FBrf0219444] Gopalakrishnan et al., 2012, Nat. Cell Biol. 14(8): 865--873 Tubulin nucleotide status controls Sas-4-dependent pericentriolar material recruitment. [FBrf0219801] Goulas et al., 2012, Cell Stem Cell 11(4): 529--540 The par complex and integrins direct asymmetric cell division in adult intestinal stem cells. [FBrf0219511] Guilgur et al., 2012, Development 139(3): 503--513 Drosophila aPKC is required for mitotic spindle orientation during symmetric division of epithelial cells. [FBrf0217157] Habermann et al., 2012, Mol. Cell. Biol. 32(17): 3554--3569 Functional Analysis of Centrosomal Kinase Substrates in Drosophila melanogaster Reveals a New Function of the Nuclear Envelope Component Otefin in Cell Cycle Progression. [FBrf0219185] Reschen et al., 2012, Biol. Open 1(5): 422--429 Dgp71WD is required for the assembly of the acentrosomal Meiosis I spindle, and is not a general targeting factor for the γ-TuRC. [FBrf0220171] Roth et al., 2012, Mol. Biol. Cell 23(8): 1524--1532 Centrosome misorientation mediates slowing of the cell cycle under limited nutrient conditions in Drosophila male germline stem cells. [FBrf0218033] Sanghavi et al., 2012, Dev. Biol. 367(1): 66--77 A functional link between localized Oskar, dynamic microtubules, and endocytosis. [FBrf0218511] Tao et al., 2012, Opt. Express 20(14): 15969--15982 Live imaging using adaptive optics with fluorescent protein guide-stars. [FBrf0218829] Chen et al., 2011, PLoS ONE 6(1): e16127 Genetic interaction of centrosomin and bazooka in apical domain regulation in Drosophila photoreceptor. [FBrf0212822] Cheng et al., 2011, Development 138(5): 831--837 Asymmetric division of cyst stem cells in Drosophila testis is ensured by anaphase spindle repositioning. [FBrf0213009] Cho et al., 2011, PLoS ONE 6(7): e22703 Wolbachia bacteria reside in host Golgi-related vesicles whose position is regulated by polarity proteins. [FBrf0214605] Gopalakrishnan et al., 2011, Nat. Commun. 2: 359 Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosome. [FBrf0216370] Lerit and Gavis, 2011, Curr. Biol. 21(6): 439--448 Transport of germ plasm on astral microtubules directs germ cell development in Drosophila. [FBrf0213255] Mottier-Pavie et al., 2011, J. Cell Sci. 124(5): 706--717 Phenotypic analysis of misato function reveals roles of noncentrosomal microtubules in Drosophila spindle formation. [FBrf0212996] Richter et al., 2011, Nat. Cell Biol. 13(9): 1029--1039 The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. [FBrf0215050] Sabino et al., 2011, J. Cell Sci. 124(7): 1156--1166 Drosophila Ajuba is not an Aurora-A activator but is required to maintain Aurora-A at the centrosome. [FBrf0213223] Sato et al., 2011, Genes Dev. 25(22): 2361--2373 Maelstrom coordinates microtubule organization during Drosophila oogenesis through interaction with components of the MTOC. [FBrf0216748] Sheng and Matunis, 2011, Development 138(16): 3367--3376 Live imaging of the Drosophila spermatogonial stem cell niche reveals novel mechanisms regulating germline stem cell output. [FBrf0214549] Szafer-Glusman et al., 2011, Mol. Biol. Cell 22(20): 3779--3790 Role of Survivin in cytokinesis revealed by a separation-of-function allele. [FBrf0216422] Taniguchi et al., 2011, Science 333(6040): 339--341 Chirality in planar cell shape contributes to left-right asymmetric epithelial morphogenesis. [FBrf0214402] Van Damme et al., 2011, PLoS Genet. 7(7): e1002169 NatF Contributes to an Evolutionary Shift in Protein N-Terminal Acetylation and Is Important for Normal Chromosome Segregation. [FBrf0214337] Wang et al., 2011, Dev. Cell 21(3): 520--533 An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts. [FBrf0215580] Wertheim et al., 2011, Mol. Ecol. 20(5): 932--949 Functional genomics of the evolution of increased resistance to parasitism in Drosophila. [FBrf0213049] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...