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Gene Dmel\Cp1

General Information
Symbol	Dmel\Cp1	Species	D. melanogaster
Name	Cysteine proteinase-1	Annotation symbol	CG6692
Feature type	protein_coding_gene	FlyBase ID	FBgn0013770
Gene Model Status	Current	Stock availability	23 publicly available
Also Known As	Dcp1, Dcp-1
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	50C18-50C20	Sequence location	2R:9,848,164..9,855,486 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Cysteine proteinase-1 is referred to in FlyBase by the symbol Dmel\Cp1 (CG6692, FBgn0013770). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: cysteine-type endopeptidase activity. There is experimental evidence that it is involved in the biological process: autophagic cell death; salivary gland cell autophagic cell death. 34 alleles are reported. The phenotypes of these alleles are annotated with: egg; adult abdominal segment 3; adult abdominal segment 1; adult abdominal segment 5; wing; adult abdominal segment 2; adult abdominal segment 4. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Peptidase C1A, papain; Peptidase C1A, papain C-terminal; Peptidase, cysteine peptidase active site; Proteinase inhibitor I29, cathepsin propeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1625264_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of Cp1. Gene sequence location is 2R:9848164..9855486.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN27765 HFA05462 BKN45134 HFA07363
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 50C18-50C20   Limits computationally determined from genome sequence between P{lacW}AGO1k00208&P{lacW}Cp1k15606 and P{lacW}Cp1k15819&P{EP}CG6701EP2054
Experimentally Determined Cytological Location
Cytogenetic map Notes References 50C-50C     (Matsumoto, 1994.6.29) 50C17-50C19   (determined by in situ hybridisation)   (Spradling et al., 1999) 50C-50C   (determined by in situ hybridisation)   (Matsumoto et al., 1995) 50C17-50C19   50C20--21   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2- (Preston et al., 1996, Matsumoto, 1994.6.29)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Cp1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Cp1-RA FBtr0087592  NM_166026   1502   341 Cp1-RB FBtr0087591  NM_166027   1495   341 Cp1-RC FBtr0087593  NM_079011   1369   371 Cp1-RD FBtr0304021  NM_001201992   1481   249
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Cp1-PA   FBpp0086718   38.0   341   6.57     NP_725347   AAF58311 Cp1-PB   FBpp0086717   38.0   341   6.57     NP_725348   AAM68566 Cp1-PC   FBpp0086719   41.6   371   7.22     NP_523735   AAM68565 Cp1-PD   FBpp0292990   27.0   249   5.10     NP_001188921   ADV37168
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase, cysteine peptidase active site (IPR000169) Peptidase C1A, papain C-terminal (IPR000668) Peptidase C1A, papain (IPR013128) Proteinase inhibitor I29, cathepsin propeptide (IPR013201) MEROPS - An information resource for peptidases and the proteins that inhibit them • C01.092
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141403   AA263895   AA264434   AA264628   AA264855   AA264900   AA390976   AA439224   AA541207   AA567095   AA567344   AA695103   AA695477   AA695610   AA695618   AA696099   AA697411   AA697965   AA735300   AA736024   AA817041   AA820133   AA941824   AA941873   AA949065   AA979189   AE013599 AAF58311   AE013599 AAM68565   AE013599 AAM68566   AE013599 ADV37168   AF012089   AI061884   AI061962   AI061984   AI062009   AI063595   AI064018   AI106631   AI107671   AI109883   AI109943   AI114274   AI134161   AI135912   AI257802   AI258074   AI260209   AI292523   AI294076   AI294483   AI295614   AI296213   AI296847   AI387140   AI387141   AI387326   AI387445   AI387450   AI387565   AI388913   AI389415   AI403154   AI403953   AI404348   AI404498   AI405742   AI405964   AI406169   AI406182   AI455299   AI456122   AI456438   AI514139   AI514213   AI515183   AI516946   AI518711   AI519690   AI520565   AI530871   AI531349   AI531578   AI531694   AI531815   AI532357   AI533114   AI533508   AI534212   AI534338   AI534961   AI542858   AI542860   AI543437   AI546120   AI546296   AI944513   AI944986   AQ026089   AQ026094   AQ073446   AQ073619   AW944590   BF486829   BF487220   BF490925   BF491860   BF492178   BF492748   BF492749   BF493288   BF495408   BF500332   BF500642   BF501822   BF502822   BF504201   BF504282   BF506701   BG632233   BG633273   BG636016   BG636445   BG637342   BG637389   BG640897   BG640926   BG640968   BG640987   BG640990   BG641019   BI142013   BI167549   BI167887   BI169737   BI229467   BI233047   BI233306   BI237422   BI237651   BI240968   BI242742   BI352621   BI353645   BI355809   BI355864   BI356458   BI370775   BI371719   BI371723   BI483824   BI564319   BI564740   BI566114   BI566149   BI567046   BI567565   BI568031   BI571939   BI571976   BI572020   BI572133   BI576971   BI579408   BI579641   BI583017   BI583347   BI583943   BI585117   BI585235   BI585293   BI585992   BI586990   BI590977   BI604943   BI609256   BI612609   BI616710   BI618115   BI621701   BI622964   BI625225   BI625435   BI625628   BI626305   BI630201   BI631656   BI632493   BI632509   BI632989   BI633044   BI633179   BI633403   BI634443   BI635024   BI635541   BI635644   BI636159   BI636313   BI636611   BI637125   BI637207   BI637538   BI638501   BI639321   BI639446   BI639485   BI639562   BI639994   BI640002   BI640302   BI640413   BI640667   BI640764   BI640797   BI641155   BI641573   BI641723   BI641758   BI641920   BP546432   BP559375   BT016071 AAV36956   BT089036   BT126233   CA803330   CA803501   CA803567   CA803782   CA803874   CA803905   CA803995   CA804080   CA804537   CA804961   CA804985   CA804989   CA805079   CA805112   CA805180   CA806046   CA806184   CA806244   CA806301   CA806374   CA806397   CA806451   CA806600   CA806761   CA806762   CA806774   CA806881   CA806922   CA806925   CA806953   CA807038   CA807076   CA807242   CA807250   CA807269   CA807289   CA807306   CA807459   CA807671   CA807777   CA807803   CA807842   CK131145   CK131889   CK132083   CK132180   CK445239   CK605150   CK657161   CK657175   CK658235   CK660555   CK660840   CK662200   CK662217   CO155650   CO156066   CO156428   CO156797   CO156911   CO177273   CO177635   CO177944   CO182242   CO184712   CO192205   CO194058   CO196155   CO262046   CO265737   CO267102   CO268365   CO272182   CO276662   CO277398   CO281124   CO283694   CO301914   CO309416   CO310704   CO312795   CO317278   CO319678   CO324124   CO324147   CO325428   CO326951   CO328017   CO329891   CO335315   CO336088   CO337149   CO337268   CO338376   CO338848   CO338855   CO342192   CO342226   CO343366   CZ482851   D31970 BAA06738   EC054602   EC058288   EC069629   EC072852   EC073225   EC083195   EC087573   EC204149   EC210545   EC213266   EC215427   EC218464   EC227828   EC229082   EC230097   EC231585   EC232204   EC232299   EC234776   EC237031   EC244798   EC249373   EC250362   EC251704   EC254174   EC255663   EC256457   EC260470   EC261270   EC262147   EC262551   EC263003   EC264267   EC264448   EC264900   EC265891   EC268001   EV576090   EV576173   EV582993   EV583194   EV584098   EV585853   EV586652   EV590822   EV592140   EV592562   EV595244   EV597066   EV597159   EV598011   EV600775   GH941205   GH941257   GH942201   GH942918   GH943041   GH943299   GH943340   GH943851   GH944067   GH944327   GH944345   GH944532   GH944790   GH945923   GH946239   GH947278   GH948730   GH949008   GH949648   GH949902   GH950030   GH950066   GH951693   GH953015   GH953256   GH953264   GH953315   GH953364   GH953807   GH954027   GH955901   GH956029   GH956188   GH956454   GH956998   GH957454   GH957881   GH957951   GH958262   GH958863   GH959463   GH960118   GH960723   GH960936   GH961640   GH962539   GH962823   GH962988   GH963307   GH964175   GH964432   GH964551   GH964740   GH965689   GH966378   GH966725   GH967210   GH967922   GH969269   GH969503   GH969532   GH969795   GH969876   GH970972   GH971159   GH971237   GH971314   GH972060   GH972112   GH972601   GH972700   GH973263   GH973705   GH973996   GH974434   GH974608   GH975031   GH975583   GH975730   GH976385   GH976662   GH977150   GH977312   GH977734   GH978149   GH979733   GH980419   GH980447   GH981067   GH981112   GH981349   GH982182   GH982461   GH982498   GH983100   GH983890   GH984602   GH984690   GH984705   GH985024   GH985073   U75652 AAB18345
UniProtKB/Swiss-Prot	Q95029
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0013770    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0013770 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0013770 expression level Developmental Stage   Expression Level embryo 00-02hr    35497 embryo 02-04hr    31755 embryo 04-06hr    27212 embryo 06-08hr    23116 embryo 08-10hr    20184 embryo 10-12hr    26392 embryo 12-14hr    15328 embryo 14-16hr    18734 embryo 16-18hr    17191 embryo 18-20hr    14196 embryo 20-22hr    6321 embryo 22-24hr    6836 larva L1    5177 larva L2    11954 larva L3 12hr old    14299 larva L3 puffstage 1-2    18516 larva L3 puffstage 3-6    35845 larva L3 puffstage 7-9    53773 white prepupae new    54152 white prepupae 12hr    51113 white prepupae 24hr    23694 pupae 2d postWPP    20914 pupae 3d postWPP    26207 pupae 4d postWPP    11306 adult male 01day    28871 adult male 05day    23138 adult male 30day    16706 adult female 01day    33372 adult female 05day    27456 adult female 30day    28551 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (35497) embryo 02-04hr  (31755) embryo 04-06hr  (27212) embryo 06-08hr  (23116) embryo 08-10hr  (20184) embryo 10-12hr  (26392) embryo 12-14hr  (15328) embryo 14-16hr  (18734) embryo 16-18hr  (17191) embryo 18-20hr  (14196) embryo 20-22hr  (6321) embryo 22-24hr  (6836) larva L1  (5177) larva L2  (11954) larva L3 12hr old  (14299) larva L3 puffstage 1-2  (18516) larva L3 puffstage 3-6  (35845) larva L3 puffstage 7-9  (53773) white prepupae new  (54152) white prepupae 12hr  (51113) white prepupae 24hr  (23694) pupae 2d postWPP  (20914) pupae 3d postWPP  (26207) pupae 4d postWPP  (11306) adult male 01day  (28871) adult male 05day  (23138) adult male 30day  (16706) adult female 01day  (33372) adult female 05day  (27456) adult female 30day  (28551) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35497) embryo 02-04hr  (31755) embryo 04-06hr  (27212) embryo 06-08hr  (23116) embryo 08-10hr  (20184) embryo 10-12hr  (26392) embryo 12-14hr  (15328) embryo 14-16hr  (18734) embryo 16-18hr  (17191) embryo 18-20hr  (14196) embryo 20-22hr  (6321) embryo 22-24hr  (6836) larva L1  (5177) larva L2  (11954) larva L3 12hr old  (14299) larva L3 puffstage 1-2  (18516) larva L3 puffstage 3-6  (35845) larva L3 puffstage 7-9  (53773) white prepupae new  (54152) white prepupae 12hr  (51113) white prepupae 24hr  (23694) pupae 2d postWPP  (20914) pupae 3d postWPP  (26207) pupae 4d postWPP  (11306) adult male 01day  (28871) adult male 05day  (23138) adult male 30day  (16706) adult female 01day  (33372) adult female 05day  (27456) adult female 30day  (28551) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (35497) embryo 02-04hr  (31755) embryo 04-06hr  (27212) embryo 06-08hr  (23116) embryo 08-10hr  (20184) embryo 10-12hr  (26392) embryo 12-14hr  (15328) embryo 14-16hr  (18734) embryo 16-18hr  (17191) embryo 18-20hr  (14196) embryo 20-22hr    6321 embryo 22-24hr    6836 larva L1    5177 larva L2  (11954) larva L3 12hr old  (14299) larva L3 puffstage 1-2  (18516) larva L3 puffstage 3-6  (35845) larva L3 puffstage 7-9  (53773) white prepupae new  (54152) white prepupae 12hr  (51113) white prepupae 24hr  (23694) pupae 2d postWPP  (20914) pupae 3d postWPP  (26207) pupae 4d postWPP  (11306) adult male 01day  (28871) adult male 05day  (23138) adult male 30day  (16706) adult female 01day  (33372) adult female 05day  (27456) adult female 30day  (28551) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35497 embryo 02-04hr    31755 embryo 04-06hr    27212 embryo 06-08hr    23116 embryo 08-10hr    20184 embryo 10-12hr    26392 embryo 12-14hr    15328 embryo 14-16hr    18734 embryo 16-18hr    17191 embryo 18-20hr    14196 embryo 20-22hr    6321 embryo 22-24hr    6836 larva L1    5177 larva L2    11954 larva L3 12hr old    14299 larva L3 puffstage 1-2    18516 larva L3 puffstage 3-6    35845 larva L3 puffstage 7-9    53773 white prepupae new    54152 white prepupae 12hr    51113 white prepupae 24hr    23694 pupae 2d postWPP    20914 pupae 3d postWPP    26207 pupae 4d postWPP    11306 adult male 01day    28871 adult male 05day    23138 adult male 30day    16706 adult female 01day    33372 adult female 05day    27456 adult female 30day    28551 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0013770 expression level Developmental Stage   Expression Level embryo 00-02hr    35497 embryo 02-04hr    31755 embryo 04-06hr    27212 embryo 06-08hr    23116 embryo 08-10hr    20184 embryo 10-12hr    26392 embryo 12-14hr    15328 embryo 14-16hr    18734 embryo 16-18hr    17191 embryo 18-20hr    14196 embryo 20-22hr    6321 embryo 22-24hr    6836 larva L1    5177 larva L2    11954 larva L3 12hr old    14299 larva L3 puffstage 1-2    18516 larva L3 puffstage 3-6    35845 larva L3 puffstage 7-9    53773 white prepupae new    54152 white prepupae 12hr    51113 white prepupae 24hr    23694 pupae 2d postWPP    20914 pupae 3d postWPP    26207 pupae 4d postWPP    11306 adult male 01day    28871 adult male 05day    23138 adult male 30day    16706 adult female 01day    33372 adult female 05day    27456 adult female 30day    28551 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (35497) embryo 02-04hr  (31755) embryo 04-06hr  (27212) embryo 06-08hr  (23116) embryo 08-10hr  (20184) embryo 10-12hr  (26392) embryo 12-14hr  (15328) embryo 14-16hr  (18734) embryo 16-18hr  (17191) embryo 18-20hr  (14196) embryo 20-22hr  (6321) embryo 22-24hr  (6836) larva L1  (5177) larva L2  (11954) larva L3 12hr old  (14299) larva L3 puffstage 1-2  (18516) larva L3 puffstage 3-6  (35845) larva L3 puffstage 7-9  (53773) white prepupae new  (54152) white prepupae 12hr  (51113) white prepupae 24hr  (23694) pupae 2d postWPP  (20914) pupae 3d postWPP  (26207) pupae 4d postWPP  (11306) adult male 01day  (28871) adult male 05day  (23138) adult male 30day  (16706) adult female 01day  (33372) adult female 05day  (27456) adult female 30day  (28551) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (35497) embryo 02-04hr  (31755) embryo 04-06hr  (27212) embryo 06-08hr  (23116) embryo 08-10hr  (20184) embryo 10-12hr  (26392) embryo 12-14hr  (15328) embryo 14-16hr  (18734) embryo 16-18hr  (17191) embryo 18-20hr  (14196) embryo 20-22hr  (6321) embryo 22-24hr  (6836) larva L1  (5177) larva L2  (11954) larva L3 12hr old  (14299) larva L3 puffstage 1-2  (18516) larva L3 puffstage 3-6  (35845) larva L3 puffstage 7-9  (53773) white prepupae new  (54152) white prepupae 12hr  (51113) white prepupae 24hr  (23694) pupae 2d postWPP  (20914) pupae 3d postWPP  (26207) pupae 4d postWPP  (11306) adult male 01day  (28871) adult male 05day  (23138) adult male 30day  (16706) adult female 01day  (33372) adult female 05day  (27456) adult female 30day  (28551) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (35497) embryo 02-04hr  (31755) embryo 04-06hr  (27212) embryo 06-08hr  (23116) embryo 08-10hr  20184 embryo 10-12hr  (26392) embryo 12-14hr  15328 embryo 14-16hr  18734 embryo 16-18hr  17191 embryo 18-20hr  14196 embryo 20-22hr    6321 embryo 22-24hr    6836 larva L1    5177 larva L2  11954 larva L3 12hr old  14299 larva L3 puffstage 1-2  18516 larva L3 puffstage 3-6  (35845) larva L3 puffstage 7-9  (53773) white prepupae new  (54152) white prepupae 12hr  (51113) white prepupae 24hr  (23694) pupae 2d postWPP  (20914) pupae 3d postWPP  (26207) pupae 4d postWPP  11306 adult male 01day  (28871) adult male 05day  (23138) adult male 30day  16706 adult female 01day  (33372) adult female 05day  (27456) adult female 30day  (28551) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    35497 embryo 02-04hr    31755 embryo 04-06hr    27212 embryo 06-08hr    23116 embryo 08-10hr    20184 embryo 10-12hr    26392 embryo 12-14hr    15328 embryo 14-16hr    18734 embryo 16-18hr    17191 embryo 18-20hr    14196 embryo 20-22hr    6321 embryo 22-24hr    6836 larva L1    5177 larva L2    11954 larva L3 12hr old    14299 larva L3 puffstage 1-2    18516 larva L3 puffstage 3-6    35845 larva L3 puffstage 7-9    53773 white prepupae new    54152 white prepupae 12hr    51113 white prepupae 24hr    23694 pupae 2d postWPP    20914 pupae 3d postWPP    26207 pupae 4d postWPP    11306 adult male 01day    28871 adult male 05day    23138 adult male 30day    16706 adult female 01day    33372 adult female 05day    27456 adult female 30day    28551 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0013770    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0013770 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0013770 expression level Tissue   Expression Level Larval Central Nervous System    839.9 Larval Midgut    2865.6 Larval Hindgut    2548.1 Larval Malpighian Tubules    4350.5 Larval Fat Body    2236.1 Larval Salivary Gland    1022.5 Larval Trachea    3603.2 Larval Carcass    2275.175 Adult Head    2500.5 Adult Eye    2495.575 Adult Brain    1105.9 Adult Thoracic-Abdominal Ganglion    1164.3 Adult Crop    1782.6 Adult Midgut    2288.6 Adult Hindgut    1986.5 Adult Malpighian Tubules    1919.5 Adult Fat Body    4448.1 Adult Salivary Gland    1580.2 Adult Heart    7471.1 Adult VirginFemale Spermatheca    5025.9 Adult InseminatedFemale Spermatheca    4235.1 Adult Ovary    1871.2 Adult Testis    1068.5 Adult Male Accessory Gland    3043.6 Adult Carcass    4350.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (839.9) Larval Midgut  (2865.6) Larval Hindgut  (2548.1) Larval Malpighian Tubules  (4350.5) Larval Fat Body  (2236.1) Larval Salivary Gland  (1022.5) Larval Trachea  (3603.2) Larval Carcass  (2275.175) Adult Head  (2500.5) Adult Eye  (2495.575) Adult Brain  (1105.9) Adult Thoracic-Abdominal Ganglion  (1164.3) Adult Crop  (1782.6) Adult Midgut  (2288.6) Adult Hindgut  (1986.5) Adult Malpighian Tubules  (1919.5) Adult Fat Body  (4448.1) Adult Salivary Gland  (1580.2) Adult Heart  (7471.1) Adult VirginFemale Spermatheca  (5025.9) Adult InseminatedFemale Spermatheca  (4235.1) Adult Ovary  (1871.2) Adult Testis  (1068.5) Adult Male Accessory Gland  (3043.6) Adult Carcass  (4350.6) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    839.9 Larval Midgut  (2865.6) Larval Hindgut  (2548.1) Larval Malpighian Tubules  (4350.5) Larval Fat Body  (2236.1) Larval Salivary Gland  1022.5 Larval Trachea  (3603.2) Larval Carcass  (2275.175) Adult Head  (2500.5) Adult Eye  (2495.575) Adult Brain  (1105.9) Adult Thoracic-Abdominal Ganglion  (1164.3) Adult Crop  (1782.6) Adult Midgut  (2288.6) Adult Hindgut  (1986.5) Adult Malpighian Tubules  (1919.5) Adult Fat Body  (4448.1) Adult Salivary Gland  (1580.2) Adult Heart  (7471.1) Adult VirginFemale Spermatheca  (5025.9) Adult InseminatedFemale Spermatheca  (4235.1) Adult Ovary  (1871.2) Adult Testis  1068.5 Adult Male Accessory Gland  (3043.6) Adult Carcass  (4350.6) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    839.9 Larval Midgut    2865.6 Larval Hindgut    2548.1 Larval Malpighian Tubules    4350.5 Larval Fat Body    2236.1 Larval Salivary Gland    1022.5 Larval Trachea    3603.2 Larval Carcass    2275.175 Adult Head    2500.5 Adult Eye    2495.575 Adult Brain    1105.9 Adult Thoracic-Abdominal Ganglion    1164.3 Adult Crop    1782.6 Adult Midgut    2288.6 Adult Hindgut    1986.5 Adult Malpighian Tubules    1919.5 Adult Fat Body    4448.1 Adult Salivary Gland    1580.2 Adult Heart    7471.1 Adult VirginFemale Spermatheca    5025.9 Adult InseminatedFemale Spermatheca    4235.1 Adult Ovary    1871.2 Adult Testis    1068.5 Adult Male Accessory Gland    3043.6 Adult Carcass    4350.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0013770 expression level Tissue   Expression Level Larval Central Nervous System    839.9 Larval Midgut    2865.6 Larval Hindgut    2548.1 Larval Malpighian Tubules    4350.5 Larval Fat Body    2236.1 Larval Salivary Gland    1022.5 Larval Trachea    3603.2 Larval Carcass    2275.175 Adult Head    2500.5 Adult Eye    2495.575 Adult Brain    1105.9 Adult Thoracic-Abdominal Ganglion    1164.3 Adult Crop    1782.6 Adult Midgut    2288.6 Adult Hindgut    1986.5 Adult Malpighian Tubules    1919.5 Adult Fat Body    4448.1 Adult Salivary Gland    1580.2 Adult Heart    7471.1 Adult VirginFemale Spermatheca    5025.9 Adult InseminatedFemale Spermatheca    4235.1 Adult Ovary    1871.2 Adult Testis    1068.5 Adult Male Accessory Gland    3043.6 Adult Carcass    4350.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (839.9) Larval Midgut  (2865.6) Larval Hindgut  (2548.1) Larval Malpighian Tubules  (4350.5) Larval Fat Body  (2236.1) Larval Salivary Gland  (1022.5) Larval Trachea  (3603.2) Larval Carcass  (2275.175) Adult Head  (2500.5) Adult Eye  (2495.575) Adult Brain  (1105.9) Adult Thoracic-Abdominal Ganglion  (1164.3) Adult Crop  (1782.6) Adult Midgut  (2288.6) Adult Hindgut  (1986.5) Adult Malpighian Tubules  (1919.5) Adult Fat Body  (4448.1) Adult Salivary Gland  (1580.2) Adult Heart  (7471.1) Adult VirginFemale Spermatheca  (5025.9) Adult InseminatedFemale Spermatheca  (4235.1) Adult Ovary  (1871.2) Adult Testis  (1068.5) Adult Male Accessory Gland  (3043.6) Adult Carcass  (4350.6) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    839.9 Larval Midgut  (2865.6) Larval Hindgut  (2548.1) Larval Malpighian Tubules  (4350.5) Larval Fat Body  (2236.1) Larval Salivary Gland  1022.5 Larval Trachea  (3603.2) Larval Carcass  (2275.175) Adult Head  (2500.5) Adult Eye  (2495.575) Adult Brain  1105.9 Adult Thoracic-Abdominal Ganglion  1164.3 Adult Crop  (1782.6) Adult Midgut  (2288.6) Adult Hindgut  (1986.5) Adult Malpighian Tubules  (1919.5) Adult Fat Body  (4448.1) Adult Salivary Gland  1580.2 Adult Heart  (7471.1) Adult VirginFemale Spermatheca  (5025.9) Adult InseminatedFemale Spermatheca  (4235.1) Adult Ovary  (1871.2) Adult Testis  1068.5 Adult Male Accessory Gland  (3043.6) Adult Carcass  (4350.6) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    839.9 Larval Midgut    2865.6 Larval Hindgut    2548.1 Larval Malpighian Tubules    4350.5 Larval Fat Body    2236.1 Larval Salivary Gland    1022.5 Larval Trachea    3603.2 Larval Carcass    2275.175 Adult Head    2500.5 Adult Eye    2495.575 Adult Brain    1105.9 Adult Thoracic-Abdominal Ganglion    1164.3 Adult Crop    1782.6 Adult Midgut    2288.6 Adult Hindgut    1986.5 Adult Malpighian Tubules    1919.5 Adult Fat Body    4448.1 Adult Salivary Gland    1580.2 Adult Heart    7471.1 Adult VirginFemale Spermatheca    5025.9 Adult InseminatedFemale Spermatheca    4235.1 Adult Ovary    1871.2 Adult Testis    1068.5 Adult Male Accessory Gland    3043.6 Adult Carcass    4350.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    2500.5   NA  Eye    2495.575   NA  Brain    1105.9   839.9  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1164.3   NA  Crop    1782.6   2865.6  Midgut    2288.6   2548.1  Hindgut    1986.5   4350.5  Malpighian Tubules    1919.5   2236.1  Fat Body    4448.1   1022.5  Salivary Gland    1580.2   NA  Heart    7471.1   3603.2  Trachea    NA   NA  VirginFemale Spermatheca    5025.9   NA  InseminatedFemale Spermatheca    4235.1   NA  Ovary    1871.2   NA  Testis    1068.5   NA  Male Accessory Gland    3043.6   2275.175  Carcass    4350.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013770 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6692-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable Cp1CC01377 Cp1llcnbw38 Cp1Wee-P118 viable, with Scer\GAL4pnr-MD237 Cp1GD5803 Sterility Allele female sterile | recessive Cp1llcnbw38 Cp1unspecified fertile Cp1Wee-P118 male fertile Cp1unspecified Other Phenotypes Allele body color defective | recessive Cp1unspecified visible | recessive Cp1k15606 Cp1k15819 Cp1unspecified Phenotype manifest in Allele adult abdominal segment 1 Cp1unspecified adult abdominal segment 2 Cp1unspecified adult abdominal segment 3 Cp1unspecified adult abdominal segment 4 Cp1unspecified adult abdominal segment 5 Cp1unspecified egg Cp1unspecified wing Cp1unspecified
Classical Alleles ( 30 )
For All Classical Alleles Show
Allele of Cp1 Class Mutagen Stocks Known lesion Cp1k15606 P-element activity 2 -- Cp1llcnbw38 2 Yes Cp1NP7036 2 -- Cp15-HA-2326 1 -- Cp150C-102 P-element activity 1 -- Cp150C-129 P-element activity 1 -- Cp150C-36 P-element activity 1 -- Cp150C-38 P-element activity 1 -- Cp1CB-0663-3 1 -- Cp1DP00318 1 -- Cp1EY05806 P-element activity 1 -- Cp1EY06822 P-element activity 1 -- Cp1f00385 piggyBac transposase 1 -- Cp1NP0545 1 -- Cp1NP2689 1 -- Cp1NP3172 1 -- Cp1NP5181 1 -- Cp1UM-8093-3 1 -- Cp150C-40 P-element activity 0 -- Cp150C-68 P-element activity 0 -- Cp150C-81 P-element activity 0 -- Cp150C-85 P-element activity 0 -- Cp150C P-element activity 0 Yes Cp1CC01377 P-element activity 0 Yes Cp1EP2270 P-element activity 0 Yes Cp1EP2476 P-element activity 0 -- Cp1k15819 P-element activity 0 -- Cp1SH1329 0 -- Cp1unspecified 0 -- Cp1Wee-P118 0 Yes
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Cp1 Class Mutagen Stocks Known lesion Cp1GD5803 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cp1HMS00725 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Cp1dsRNA.cHa in vitro construct - RNAi 0 Yes Cp1KK107765 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)50C-16 (Preston et al., 1996) Df(2R)50C-21 (Preston et al., 1996) Df(2R)50C-36 (Preston et al., 1996) Df(2R)50C-38 (Preston et al., 1996) Df(2R)50C-40 (Preston et al., 1996) Df(2R)50C-43 (Preston et al., 1996) Df(2R)50C-45 (Preston et al., 1996) Df(2R)50C-49 (Preston et al., 1996) Df(2R)50C-68 (Preston et al., 1996) Df(2R)50C-69 (Preston et al., 1996) Df(2R)50C-71 (Preston et al., 1996) Df(2R)50C-81 (Preston et al., 1996) Df(2R)50C-85 (Preston et al., 1996) Df(2R)50C-89 (Preston et al., 1996) Df(2R)50C-101 (Preston et al., 1996) Df(2R)50C-102 (Preston et al., 1996) Df(2R)50C-107 (Preston et al., 1996) Df(2R)50C-111 (Preston et al., 1996) Df(2R)50C-116 (Preston et al., 1996) Df(2R)50C-128 (Preston et al., 1996) Df(2R)50C-129 (Preston et al., 1996) Df(2R)50C-131 (Preston et al., 1996) Df(2R)50C-132 (Preston et al., 1996) Df(2R)50C-133 (Preston et al., 1996) Df(2R)Exel7129 (Ryder, 2004.4.26) Df(2R)mam04615 (Preston et al., 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5803} NA P{KK107765} NA P{TRiP.HMS00725} NA characterization construct P{Tub-Cp1-RNAi} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}CG13349EP2270 NA P{EP}Cp1EP2476 NA P{EPgy2}Cp1EY05806 NA P{EPgy2}Cp1EY06822 NA P{Mae-UAS.6.11}Cp1DP00318 NA insertion of enhancer trap P{lacW}Cp1k15606 No P{lacW}Cp1k15819 No P{lacW}Cp1SH1329 No P{lacW}l(2)SH2324SH2324 No miscellaneous insertions P{CaSpeR}Cp150C-36 NA P{CaSpeR}Cp150C-38 NA P{CaSpeR}Cp150C-40 NA P{CaSpeR}Cp150C-68 NA P{CaSpeR}Cp150C-81 NA P{CaSpeR}Cp150C-85 NA P{CaSpeR}Cp150C-102 NA P{CaSpeR}Cp150C-129 NA P{CaSpeR}Cp150C NA P{PTT-GC}Cp1CC01377 NA P{RS3}Cp1CB-0663-3 NA P{RS3}Cp1UM-8093-3 NA P{RS5}Cp15-HA-2326 NA P{Wee-P.ph0}Cp1Wee-P118 NA PBac{WH}Cp1f00385 NA insertion of enhancer trap binary system P{GawB}Cp1NP0545 No P{GawB}Cp1NP2689 No P{GawB}Cp1NP3172 No P{GawB}Cp1NP5181 No P{GawB}Cp1NP7036 No
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
autophagic cell death inferred from expression pattern (Gorski et al., 2003) salivary gland cell autophagic cell death inferred from expression pattern (Gorski et al., 2003)
Cellular Component
CV term Evidence References
fusome inferred from direct assay (Lighthouse et al., 2008)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
cysteine-type endopeptidase activity inferred from sequence or structural similarity with UniProtKB:Q26636 (FlyBase, 1992-) non-traceable author statement (Matsumoto, 1994.6.29, Swiss-Prot Project Members, 2000.10.1)
Biological Process
CV term Evidence References
protein catabolic process non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) proteolysis inferred from electronic annotation with InterPro:IPR000169, InterPro:IPR000668 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
lysosome non-traceable author statement (Swiss-Prot Project Members, 2000.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Cp1 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62300 DroID - A comprehensive database of gene and protein interactions. • FBgn0013770 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36546
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13722 Dere\GG20414 Dgri\GH22826 Dmoj\GI21205 Dper\GL17172 Dpse\GA25021 Dsec\GM21500 Dsim\GD10995 Dvir\GJ20806 Dwil\GK19626 Dyak\GE12574
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002833-PA Aedes aegypti (mosquito) AGAP011828-PA Anopheles gambiae (mosquito) XP_625135.2 Apis mellifera (honey bee) XP_001944978.1 Acyrthosiphon pisum (pea aphid) At3g19390.1 Arabidopsis thaliana (wall cress) 284308 Branchiostoma floridae (lancelet) XP_001895531.1 Brugia malayi (roundworm nematode) BGIBMGA011342-PA Bombyx mori (silk worm) ENSBTAP00000022710 Bos taurus (bovine) CN18710 Caenorhabditis brenneri (small nematode) CBP05395 Caenorhabditis briggsae (nematode) CE16333 Caenorhabditis elegans (worm) ENSCAFP00000001630 Canis familiaris (dog) Chro.60563 Cryptosporidium hominis (obligate parasite) ENSCINP00000015734 Ciona intestinalis (sea squirt) JA04355 Caenorhabditis japonica (nematode) CPIJ006471 Culex pipens (mosquito) ENSCPOP00000008278 Cavia porcellus (guinea pig) 120266 Chlamidomonas reinhardtii (green alga) RP24905 Caenorhabditis remanei (nematode) ENSCSAVP00000017814 Ciona savignyi (sedentary tunicate) 165495 Capitella spl (polychaete worm) DDB0185092 Dictyostelium discoideum (amoeba) 228587 Daphnia pulex (daphnia) 299592 Daphnia pulex (daphnia) ENSDARP00000007127 Danio rerio (zebra fish) ENSECAP00000004288 Equus caballus (horse) XP_650937 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000012715 Gymnopilus aculeatus (mushroom) ENSGALP00000020559 Gallus gallus (chicken) GL50803_112831 Giardia lamblia (flagellated protozoan) GL50803_113656 Giardia lamblia (flagellated protozoan) GL50803_114773 Giardia lamblia (flagellated protozoan) GL50803_114915 Giardia lamblia (flagellated protozoan) 185160 Hypsipyla robusta (cedar shoot borer) ENSP00000365073 Homo sapiens (human) ISCW009204-PA Ixodes scapularis (deer tick) 204652 Lottia gigantea (owl limpet) LmjF19.1420 Leishmania major (virus) 1982 Monocosta brevicollis (choanoflagellate) ENSMODP00000003454 Monodelphis domestica (gray opossum) ENSMMUP00000023174 Macaca mulatta (rhesus monkey) ENSMUSP00000021933 Mus musculus (house mouse) 181181 Nematostella vectensis (starlet anemone) XP_001602523.1 Nasonia vitripennis (wasp) ENSOANP00000000382 Ornithorynchus anatinus (platypus) ENSORLP00000025760 Oryzias latipes (japanese killifish) LOC_Os08g44270.1 Oryza sativa (asian rice) 4131 Ostreococcus tauri (green alga) PF11_0161 Plasmodium falciparum (protozoal parasite) PHUM000383-PA Pediculus humanus (human body louse) PP09208 Pristionchus pacificus (nematode) 224348 Physcomitrella patens (moss) ENSPPYP00000021679 Pongo pygmaeus (orangutan) 42145 Phytophthora ramorum (sudden oak death pathogen) 127808 Phytophthora sojae (root rot pathogen) 559786 Populus trichocarpa (black cottonwood) ENSPTRP00000036034 Pan troglodytes (chimpanzee) PVX_091415 Plasmodium vivax (protozoal parasite) ENSRNOP00000025462 Rattus norvegicus (norway rat) 4762590 Sorghum bicolor (sorghum) XP_001181760.1 Strongylocentrotus purpuratus (purple sea urchin) 35658 Trichoplax adhaerens (metazoa) TA03720 Theileria annulata (apicomplexan parasite) XP_970644.1 Tribolium castaneum (red flour beetle) Tc00.1047053507603.260 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507603.270 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509429.320 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000018709 Tetraodon nigroviridis (green spotted pufferfish) TP03_0283 Theileria parva (parasitic protozoan) 16390 Thalassiosira pseudonana (marine diatom) ENSTRUP00000040431 Takifugu rubripes (pufferfish Takifugu) 304.m00023 Tetrahymena thermophila (ciliate protozoa) 86997.m00181 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000057468 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16336 NV16445 NV16446 LH14352 ISCW009204 FBgn0230305 FBgn0221624 FBgn0207943 FBgn0182755 FBgn0176380 JGI_V11_228587 JGI_V11_299592 FBgn0246404 FBgn0154775 FBgn0143935 FBgn0130283 FBgn0112604 FBgn0094618 FBgn0090749 CPIJ006471 BGIBMGA011342 ACYPI006974 GB19923 AGAP011828 AAEL011167 AAEL002833 PHUM479600 GLEAN_11003
Stocks & Reagents
Stocks Listed in FlyBase ( 23 )
Bloomington	5124 cn1 Cp1llcnbw38 bw1/CyO 15957 y1 w67c23; P{EPgy2}Cp1EY05806 15974 y1 w67c23; P{EPgy2}Cp1EY06822 32932 y1 sc* v1; P{TRiP.HMS00725}attP2
Harvard	- PBac{WH}Cp1f00385
Kyoto	113139 w*; P{GawB}Cp1NP3172 123275 w1118; P{RS3}Cp1CB-0663-3 124335 w1118; P{RS3}Cp1UM-8093-3 125597 w1118; P{RS5}Cp15-HA-2326 113009 w*; P{GawB}Cp1NP2689 / CyO 108056 cn1 Cp1llcnbw38 bw1/CyO
VDRC	v13959 w1118; P{GD5803}v13959
	More stocks available...
Genomic Clones ( 1 )
	BACR06M19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 463 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP06554 RE21773
Other clones	SD23574
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01613 AT04248 AT05512 AT05621 AT09255 AT15180 AT15636 AT17382 AT18653 AT21367 AT21945 AT27560 AT28623 AT29067 GH01010 GH01046 GH03020 GH03501 GH05480 GH05484 GH06439 GH06694 GH09269 GH09349 GH11069 GH13834 GH15445 GH17583 GH17826 GH17975 GH17982 GH18124 GH19962 GH20578 GH22537 GH23475 GH23512 GH24012 GH25862 GH26127 GH26382 GH26403 GH27209 GH27291 GH27555 GM01059 GM02144 GM02886 GM05061 GM24551 GM32639 HL01089 HL02425 LD07104 LD08153 LD08243 LD09347 LD09556 LD09792 LD13727 LD21046 LD22039 LD27123 LD27187 LD27818 LD33483 LD35070 LD35973 LD36459 LD38407 LD39364 LD40760 LD46205 LD46896 LD47838 LP01166 LP06278 LP07371 LP07863 LP09293 LP10944 LP12939 LP13328 LP13501 LP14230 LP19759 LP22235 LP23246 LP23264 RE07954 RE08377 RE11004 RE27250 RE29313 RE29616 RE33649 RE33914 RE37937 RE42619 RE57518 RE58666 RE58671 RE66773 RE73435 RE73707 RH04672 RH07260 RH07307 RH07355 RH07480 RH14017 RH21449 RH21938 RH24591 RH24812 RH24883 RH25710 RH33688 RH35238 RH35309 RH36876 RH37208 RH37989 RH38496 RH39372 RH41542 RH48664 RH53091 RH59190 RH61277 RH62240 RH65853 RH66090 RH70448 SD01260 SD01619 SD01630 SD02347 SD02673 SD02930 SD03084 SD03847 SD04828 SD05361 SD06795 SD07138 SD09355 SD10183 SD12067 SD12109 SD12163 SD12185 SD12189 SD12239 SD13584 SD14160 SD15279 SD15384 SD16004 SD16916 SD17057 SD17747 SD17953 SD18349 SD19047 SD19154 SD19579 SD20803 SD21878 SD22022 SD22066 SD22176 SD22740 SD22752 SD23122 SD23258 SD23630 SD23758 SD23794 SD24361 SD24967 SD25295 SD25363 SD25588 SD26287 SD26308 SD26908 SD27012 SD27185 SD27476
Other clones	989 5255 7737 33040 34374 38001 39059 59299 83610 99722 105152 147941 162875 163607 175355 191301 214243.44 214319.29 214477.26 214477.27 214507.25 527110 527921 528251 533454 533994 562212 571270 571336 576503 AT01169 bs03d07 bs07g01 CK01.11B.E2 CK01.65A.D2 CK01.66B.D12 CK01.68B.E2 CK01.119C.A4 CK02313 Dmel_dig_000647_0689_0353 Dmel_dig_000859_0673_0294 Dmel_dig_011630_0704_0436 Dmel_dig_012350_0616_1235 Dmel_dig_013853_0650_2650 Dmel_dig_018025_0646_0815 Dmel_neb_006262_0919_0442 Dmel_neb_009073_0601_0898 Dmel_neb_009361_0685_0759 Dmel_neb_013036_0662_0800 Dmel_neb_013746_0951_1978 Dmel_neb_014292_0949_3500 Dmel_neb_014521_0082_0692 Dmel_neb_014745_0872_1274 Dmel_neb_014868_0384_1801 EC22318 EC28451 EC33348 EC37342 EC054602 EK001308 EK053045 EK053946 EK054749 EK084010 EK091134 EK106121 EK121763 EK124320 EK143518 EK148731 EK156024 EK164116 EK182708 EK192709 EK192807 EK196508 EK217538 EK222324 EK229978 EK267612 EK279950 EK294117 EN06506 EN07264 EN08041 EN09327 EN09543 EN10012 EN11809 EN13923 EN14161 EN16644 EN17807 EN17817 EP05038 EP08430 EP14130 EP14206 EP16648 ESG011b.E21_D03 ESG011c.E7_E02 ESG011c.E21_E02 ESG012b.TE_C05 ESG012c.E21_A08 ESG012c.E21_H10 ESG013a.E21_C12 ESG013a.E21.1_G02 ESG013b.E21_H04 ESG014a.E21_E10 ESG014d.E21_G01 ESG014d.E21_G03 ESG014d.E21_H12 ESG015b.E21_H04 ESG015c.E21_E03 ESG015c.E21_H10 ESG015c.E21.1_E07 ESG016a.E21_A03 ESG016a.E21_G08 ESG017a.E21_C01 ESG017a.E21_D06 ESG017b.E21_A03 ESG017b.E21_D01 ESG017b.E21_F03 ESG018a.E21_C05 ESG018d.E21_G10 ESG019c.E21_C06 ESG019c.E21_G03 ESG019d.E21_G04 ESG0110c.E21.1_C04 ESG0111a.B21.1_C05 ESG0111a.B21.1_G07 ESG0111c.B21_F09 ESG0112a.B21_A12 ESG0114a.B21_D11 ESG0115d.B21_G12 ESG0116a.B21_B10 ESG0116a.B21_C07 ESG0116b.B21_G11 ESG0116c.B21_C11 ESG0116d.B21_E10 ESG0120d.B21_C03 FGH106D02 FGM320E09 GH04265 GH11539 GH17584 GH24239 GM03122 GM03134 GM10801 GM20088 GM32440 HL03539 LD09502 LD22785 LP03920 LP10051 LP15020 LP19203 LP22262 RE40158 RH22668 RH27235 RH46764 RH55013 RH65521 RH66878 RP004020462 RP004038426 RP004046641 RP004047930 RP004058932 RP004068433 RP004077716 RP004084059 RP004086641 RP004088541 RP004120240 RP004123922 RP004131258 RP004131902 RP004132408 RP004132943 RP004135750 RP004155156 RP004177186 RP004178313 RP004178414 RP004180470 RP004192048 RP004194279 RP004196580 RP004205030 RP004210595 RP004213542 RP004220266 RP004220843 RP004221509 RP004224398 RP004226934 RP004232715 RP004233884 RP004234164 RP004236259 RP004237059 RP004240043 RP004240285 RP004241034 RP004241196 RP004242053 RP004242197 RP004245239 RP004245961 RP004247505 RP004248246 RP004251055 RP004252985 RP004253681 RP004255070 RP004258106 RP004262296 RP004263468 RP004269441 RP004269594 RP004280714 RP004296204 RP004300730 RP004313832 RP004321331 RP004336449 RP004339527 RP004352338 RP004359438 RP004363303 RP004371871 RP004376869 RP004384882 RP004393491 RP004395354 RP004402071 RP004403428 RP004414498 RP004415636 RP004416852 RP004419292 RP004434536 RP004436612 RP004440708 RP004441048 RP004443605 RP004461464 RP004470224 RP004476535 RP004480945 RP004489629 RP004500225 RP004502522 RP004503887 RP004506685 RP004515783 RP004519547 RP004521008 RP004524350 RP004532481 RP004539271 RP004543719 RP004549141 RP004558265 SD09359 UT01715
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0013770 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36546
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Isolation and characterisation of Cp1. (Tryselius and Hultmark, 1997) Complementation group identified during analysis of deficiency chromosomes caused by Δ2-3 mobilisation of P{CaSpeR}Cp150C. (Preston et al., 1996) Cp1 encodes a cysteine proteinase and is predominantly expressed in the midgut and the salivary gland. (Matsumoto et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079011 NM_166026 NM_166027 NM_001201992 RefSeq (Proteins) • NP_523735 NP_725347 NP_725348 NP_001188921 DDBJ / EMBL / GenBank • AA695477 AAB18345 AAB65749 AAF58311 AAM68565 AAM68566 AAV36956 ADV37168 AF012089 AI296213 AI542860 AI944513 AI944986 AQ026089 AQ026094 AQ073446 AQ073619 AW944590 BAA06738 BT016071 CZ482851 D31970 U75652 Entrez Gene - A searchable database of RefSeq genes. • 36546 UniProtKB/Swiss-Prot • Q95029
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase, cysteine peptidase active site (IPR000169) Peptidase C1A, papain C-terminal (IPR000668) Peptidase C1A, papain (IPR013128) Proteinase inhibitor I29, cathepsin propeptide (IPR013201) MEROPS - An information resource for peptidases and the proteins that inhibit them • C01.092
Linkouts
	BioGRID - A database of protein and genetic interactions • 62300 DroID - A comprehensive database of gene and protein interactions. • FBgn0013770 DRSC - Results from RNAi screens. • FBgn0013770 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013770 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6692-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0013770 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36546 InParanoid A subset of ortholog calls from InParanoid. • AAEL002833-PA Aedes aegypti (mosquito) AGAP011828-PA Anopheles gambiae (mosquito) XP_625135.2 Apis mellifera (honey bee) XP_001944978.1 Acyrthosiphon pisum (pea aphid) At3g19390.1 Arabidopsis thaliana (wall cress) 284308 Branchiostoma floridae (lancelet) XP_001895531.1 Brugia malayi (roundworm nematode) BGIBMGA011342-PA Bombyx mori (silk worm) ENSBTAP00000022710 Bos taurus (bovine) CN18710 Caenorhabditis brenneri (small nematode) CBP05395 Caenorhabditis briggsae (nematode) CE16333 Caenorhabditis elegans (worm) ENSCAFP00000001630 Canis familiaris (dog) Chro.60563 Cryptosporidium hominis (obligate parasite) ENSCINP00000015734 Ciona intestinalis (sea squirt) JA04355 Caenorhabditis japonica (nematode) CPIJ006471 Culex pipens (mosquito) ENSCPOP00000008278 Cavia porcellus (guinea pig) 120266 Chlamidomonas reinhardtii (green alga) RP24905 Caenorhabditis remanei (nematode) ENSCSAVP00000017814 Ciona savignyi (sedentary tunicate) 165495 Capitella spl (polychaete worm) DDB0185092 Dictyostelium discoideum (amoeba) 228587 Daphnia pulex (daphnia) 299592 Daphnia pulex (daphnia) ENSDARP00000007127 Danio rerio (zebra fish) ENSECAP00000004288 Equus caballus (horse) XP_650937 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000012715 Gymnopilus aculeatus (mushroom) ENSGALP00000020559 Gallus gallus (chicken) GL50803_112831 Giardia lamblia (flagellated protozoan) GL50803_113656 Giardia lamblia (flagellated protozoan) GL50803_114773 Giardia lamblia (flagellated protozoan) GL50803_114915 Giardia lamblia (flagellated protozoan) 185160 Hypsipyla robusta (cedar shoot borer) ENSP00000365073 Homo sapiens (human) ISCW009204-PA Ixodes scapularis (deer tick) 204652 Lottia gigantea (owl limpet) LmjF19.1420 Leishmania major (virus) 1982 Monocosta brevicollis (choanoflagellate) ENSMODP00000003454 Monodelphis domestica (gray opossum) ENSMMUP00000023174 Macaca mulatta (rhesus monkey) ENSMUSP00000021933 Mus musculus (house mouse) 181181 Nematostella vectensis (starlet anemone) XP_001602523.1 Nasonia vitripennis (wasp) ENSOANP00000000382 Ornithorynchus anatinus (platypus) ENSORLP00000025760 Oryzias latipes (japanese killifish) LOC_Os08g44270.1 Oryza sativa (asian rice) 4131 Ostreococcus tauri (green alga) PF11_0161 Plasmodium falciparum (protozoal parasite) PHUM000383-PA Pediculus humanus (human body louse) PP09208 Pristionchus pacificus (nematode) 224348 Physcomitrella patens (moss) ENSPPYP00000021679 Pongo pygmaeus (orangutan) 42145 Phytophthora ramorum (sudden oak death pathogen) 127808 Phytophthora sojae (root rot pathogen) 559786 Populus trichocarpa (black cottonwood) ENSPTRP00000036034 Pan troglodytes (chimpanzee) PVX_091415 Plasmodium vivax (protozoal parasite) ENSRNOP00000025462 Rattus norvegicus (norway rat) 4762590 Sorghum bicolor (sorghum) XP_001181760.1 Strongylocentrotus purpuratus (purple sea urchin) 35658 Trichoplax adhaerens (metazoa) TA03720 Theileria annulata (apicomplexan parasite) XP_970644.1 Tribolium castaneum (red flour beetle) Tc00.1047053507603.260 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053507603.270 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053509429.320 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000018709 Tetraodon nigroviridis (green spotted pufferfish) TP03_0283 Theileria parva (parasitic protozoan) 16390 Thalassiosira pseudonana (marine diatom) ENSTRUP00000040431 Takifugu rubripes (pufferfish Takifugu) 304.m00023 Tetrahymena thermophila (ciliate protozoa) 86997.m00181 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000057468 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36546 modMine - Data generated by the modENCODE project. • FBgn0013770 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16336 NV16445 NV16446 LH14352 ISCW009204 FBgn0230305 FBgn0221624 FBgn0207943 FBgn0182755 FBgn0176380 JGI_V11_228587 JGI_V11_299592 FBgn0246404 FBgn0154775 FBgn0143935 FBgn0130283 FBgn0112604 FBgn0094618 FBgn0090749 CPIJ006471 BGIBMGA011342 ACYPI006974 GB19923 AGAP011828 AAEL011167 AAEL002833 PHUM479600 GLEAN_11003
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	CG6692 (Kraut et al., 2001, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Cammarato et al., 2011) cp1 (Sriram et al., 2003, Clyne et al., 2003) CP1 (Tryselius, 1996.10.22, Gray, 1997.6.30, Lankenau and Gloor, 1998, Tryselius and Hultmark, 1997, Deshapriya et al., 2007, Gouw et al., 2009) Cp1 (Buszczak et al., 2007, Doheny et al., 2008, Chittaranjan et al., 2009, Dworkin et al., 2009, Lighthouse et al., 2008, Curtis et al., 2007, Kong et al., 2010) CT20780 (Ceriani et al., 2002) CysP-1   Dcp-1 (Meier and Silke, 2003, White, 2000, Fan and Bergmann, 2008, Yi et al., 2007, Thakar and Csink, 2005) Dcp1 (Abrams, 1999, Hay et al., 2004, Bonini and Fortini, 1999, Wilhelm, 2007, Montell, 2006) DCP1 (Matsumoto et al., 1995) fs(2)50Ca (Preston et al., 1996, ) unnamed (Berres and Engels, 1997, Preston and Engels, 1996)
Name Synonym	Cathepsin L (Sweeney and Davis, 2002) cathepsin L (Tryselius and Hultmark, 1995, Kuronen et al., 2006) cysteine proteinase-1 (Matsumoto, 1994.6.29) Cysteine proteinase-1 (Cammarato et al., 2011) cysteine proteinase 1 (Deshapriya et al., 2007) Drosophila Cysteine proteinase-1 (Matsumoto et al., 1995)
Secondary FlyBase IDs
	FBgn0019814
References ( 69 )
Generate a list of	All references relating to this gene ( 69 )
List References by type	Research paper  ( 28 ) Supplementary material  ( 6 ) Review  ( 7 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Computer file  ( 4 ) Protein sequence record  ( 1 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 2 )
	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Kong et al., 2010, Alcoholism, Clin. Exp. Res. 34(2): 302--316 Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. [FBrf0209720] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...