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Gene Dmel\DNA-ligII

General Information
Symbol	Dmel\DNA-ligII	Species	D. melanogaster
Name	DNA ligase II	Annotation symbol
Feature type	gene	FlyBase ID	FBgn0013775
Gene Model Status	Unannotated	Stock availability	None publicly available
Genomic Location
Chromosome (arm)		Recombination map
Cytogenetic map		Sequence location
Summary Information
Automatically generated summary See sections below for more information	The gene DNA ligase II is referred to in FlyBase by the symbol Dmel\DNA-ligII (FBgn0013775). It is a gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: DNA ligase (ATP) activity. The biological processes in which it is involved are not known. No alleles are reported. It has no annotated transcripts. Gene has not been localized to the genome sequence.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments	The properties of two DNA ligases purified from embryos were compared. The enzymes differ in size, thermostability, affinity for ATP, Km, and optimal reaction conditions (salt optima, requirement for DTT, and reaction to PVA). They are similar in requirement for ATP as cofactor and Mg2+ as divalent cation, inhibition by N-ethylmaleimide, optimal ligation temp, and substrate specificity. The major AMP-adduct has a molecular weight of 70kD. (Takahashi and Senshu, 1987)
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Mapped Features
Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
	Activity was detected throughout embryogenesis. (Takahashi and Senshu, 1987)
Marker for
Subcellular Localization
CV Term	nucleus (Takahashi and Senshu, 1987)
Notes
High-Throughput Expression Data
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of DNA-ligII Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of DNA-ligII Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function
CV term Evidence References
DNA ligase (ATP) activity inferred from direct assay (Takahashi and Senshu, 1987)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Takahashi and Senshu, 1987)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions DNA-ligII allele Gene References
External Data
Linkouts
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 0 )
cDNA Clones ( 0 )
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Purification and characterisation of DNA-ligII from pupae. DNA-ligII is distinct from DNA-ligI both in developmental appearance and biochemical properties. (Takahashi and Tomizawa, 1990) 2 distinct DNA ligases are present in embryos, DNA-ligI and DNA-ligII. They have similarities to mammalian DNA ligases I and II. This suggests there are two different DNA ligases in lower eukaryotes that may have different roles in DNA metabolism. (Takahashi and Senshu, 1987)
External Crossreferences & Linkouts
Sequence Crossreferences
Other Crossreferences
Linkouts
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	DNA-ligII
Name Synonym	DNA ligase II
Secondary FlyBase IDs
	FBgn0004596
References ( 4 )
Research paper	Gene Ontology Consortium, 2000, Nature Genetics 25(1): 25--29 Gene Ontology: tool for the unification of biology. [FBrf0133249] Lasko et al., 1990, Mutat. Res. 236(2/3): 277--287 Eukaryotic DNA ligases. [FBrf0052622] Takahashi and Tomizawa, 1990, Europ. J. Biochem. 192(3): 735--740 Purification and characterization of DNA ligase II from Drosophila melanogaster. [FBrf0051704] Takahashi and Senshu, 1987, FEBS Lett. 213: 345--352 Two distinct DNA ligases from Drosophila melanogaster embryos. [FBrf0046241]