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Gene Dmel\Dhc93AB

General Information
Symbol	Dmel\Dhc93AB	Species	D. melanogaster
Name	Dynein heavy chain at 93AB	Annotation symbol	CG3723
Feature type	protein_coding_gene	FlyBase ID	FBgn0013812
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	dhc
Genomic Location
Chromosome (arm)	3R	Recombination map	3-
Cytogenetic map	93B5-93B7	Sequence location	3R:16,850,741..16,868,141 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Dynein heavy chain at 93AB is referred to in FlyBase by the symbol Dmel\Dhc93AB (CG3723, FBgn0013812). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATPase activity, coupled; motor activity. Based on sequence similarity, it is predicted to be involved in the biological process: microtubule-based movement. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: ATPase, AAA+ type, core; ATPase, dynein-related, AAA domain; Dynein heavy chain; Dynein heavy chain, P-loop containing D4 domain; Dynein heavy chain, coiled coil stalk; Dynein heavy chain, domain-1; Dynein heavy chain, domain-2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1630304_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Dhc93AB. Gene sequence location is 3R:16850741..16868141.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN20706 HFA16644
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 93B5-93B7   Limits computationally determined from genome sequence between P{PZ}Atpα01164 and P{PZ}mod(mdg4)07038&P{lacW}mod(mdg4)L3101
Experimentally Determined Cytological Location
Cytogenetic map Notes References 93A-93B     (Li, 1993) 93A-93B   (determined by in situ hybridisation)   (Rasmusson et al., 1994)
Experimentally Determined Recombination Data
Location	3- (Li, 1993)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Dhc93AB for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Dhc93AB-RB FBtr0273236  NM_079700   13461   4486
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Dhc93AB-PB   FBpp0271744   514.0   4486   5.14     NP_524424   AAF55834
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Dynein heavy chain (IPR004273) ATPase, dynein-related, AAA domain (IPR011704) Dynein heavy chain, domain-2 (IPR013602) ATPase, AAA+ type, core (IPR003593) Dynein heavy chain, P-loop containing D4 domain (IPR024317) Dynein heavy chain, coiled coil stalk (IPR024743) Dynein heavy chain, domain-1 (IPR013594)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55834   EW713136   EW713205   EY198819   GR705704   GR705723   GR705745   GR705758   GR705759   L23198 AAA52090
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VDG0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
pcr Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Rasmusson et al., 1994) adult stage | female     (Rasmusson et al., 1994) adult stage | male     (Rasmusson et al., 1994)
Additional Descriptive Data
	Dhc93AB transcripts are detected in males, females and embryos by RT-PCR. (Rasmusson et al., 1994)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006, Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0013812    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0013812 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0013812 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    40 embryo 08-10hr    33 embryo 10-12hr    30 embryo 12-14hr    37 embryo 14-16hr    40 embryo 16-18hr    62 embryo 18-20hr    69 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    38 larva L2    16 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    5 white prepupae 24hr    15 pupae 2d postWPP    36 pupae 3d postWPP    39 pupae 4d postWPP    57 adult male 01day    99 adult male 05day    104 adult male 30day    114 adult female 01day    49 adult female 05day    11 adult female 30day    17 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    40 embryo 08-10hr    33 embryo 10-12hr    30 embryo 12-14hr    37 embryo 14-16hr    40 embryo 16-18hr    62 embryo 18-20hr    69 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    38 larva L2    16 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    5 white prepupae 24hr    15 pupae 2d postWPP    36 pupae 3d postWPP    39 pupae 4d postWPP    57 adult male 01day    99 adult male 05day  104 adult male 30day  (114) adult female 01day    49 adult female 05day    11 adult female 30day    17 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    40 embryo 08-10hr    33 embryo 10-12hr    30 embryo 12-14hr    37 embryo 14-16hr    40 embryo 16-18hr    62 embryo 18-20hr    69 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    38 larva L2    16 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    5 white prepupae 24hr    15 pupae 2d postWPP    36 pupae 3d postWPP    39 pupae 4d postWPP    57 adult male 01day    99 adult male 05day    104 adult male 30day    114 adult female 01day    49 adult female 05day    11 adult female 30day    17 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    40 embryo 08-10hr    33 embryo 10-12hr    30 embryo 12-14hr    37 embryo 14-16hr    40 embryo 16-18hr    62 embryo 18-20hr    69 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    38 larva L2    16 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    5 white prepupae 24hr    15 pupae 2d postWPP    36 pupae 3d postWPP    39 pupae 4d postWPP    57 adult male 01day    99 adult male 05day    104 adult male 30day    114 adult female 01day    49 adult female 05day    11 adult female 30day    17 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    40 embryo 08-10hr    33 embryo 10-12hr    30 embryo 12-14hr    37 embryo 14-16hr    40 embryo 16-18hr    62 embryo 18-20hr    69 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    38 larva L2    16 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    5 white prepupae 24hr    15 pupae 2d postWPP    36 pupae 3d postWPP    39 pupae 4d postWPP    57 adult male 01day    99 adult male 05day    104 adult male 30day    114 adult female 01day    49 adult female 05day    11 adult female 30day    17 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0013812 expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    40 embryo 08-10hr    33 embryo 10-12hr    30 embryo 12-14hr    37 embryo 14-16hr    40 embryo 16-18hr    62 embryo 18-20hr    69 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    38 larva L2    16 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    5 white prepupae 24hr    15 pupae 2d postWPP    36 pupae 3d postWPP    39 pupae 4d postWPP    57 adult male 01day    99 adult male 05day    104 adult male 30day    114 adult female 01day    49 adult female 05day    11 adult female 30day    17 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    40 embryo 08-10hr    33 embryo 10-12hr    30 embryo 12-14hr    37 embryo 14-16hr    40 embryo 16-18hr    62 embryo 18-20hr    69 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    38 larva L2    16 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    5 white prepupae 24hr    15 pupae 2d postWPP    36 pupae 3d postWPP    39 pupae 4d postWPP    57 adult male 01day    99 adult male 05day  104 adult male 30day  114 adult female 01day    49 adult female 05day    11 adult female 30day    17 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    40 embryo 08-10hr    33 embryo 10-12hr    30 embryo 12-14hr    37 embryo 14-16hr    40 embryo 16-18hr    62 embryo 18-20hr    69 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    38 larva L2    16 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    5 white prepupae 24hr    15 pupae 2d postWPP    36 pupae 3d postWPP    39 pupae 4d postWPP    57 adult male 01day    99 adult male 05day    104 adult male 30day    114 adult female 01day    49 adult female 05day    11 adult female 30day    17 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    40 embryo 08-10hr    33 embryo 10-12hr    30 embryo 12-14hr    37 embryo 14-16hr    40 embryo 16-18hr    62 embryo 18-20hr    69 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    38 larva L2    16 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    5 white prepupae 24hr    15 pupae 2d postWPP    36 pupae 3d postWPP    39 pupae 4d postWPP    57 adult male 01day    99 adult male 05day    104 adult male 30day    114 adult female 01day    49 adult female 05day    11 adult female 30day    17 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    2 embryo 04-06hr    9 embryo 06-08hr    40 embryo 08-10hr    33 embryo 10-12hr    30 embryo 12-14hr    37 embryo 14-16hr    40 embryo 16-18hr    62 embryo 18-20hr    69 embryo 20-22hr    51 embryo 22-24hr    48 larva L1    38 larva L2    16 larva L3 12hr old    6 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    6 white prepupae new    6 white prepupae 12hr    5 white prepupae 24hr    15 pupae 2d postWPP    36 pupae 3d postWPP    39 pupae 4d postWPP    57 adult male 01day    99 adult male 05day    104 adult male 30day    114 adult female 01day    49 adult female 05day    11 adult female 30day    17 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0013812    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0013812 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0013812 expression level Tissue   Expression Level Larval Central Nervous System    7.025 Larval Midgut no informative data Larval Hindgut    7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.375 Larval Carcass no informative data Adult Head    33.3 Adult Eye no informative data Adult Brain    8.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    7.025 Larval Midgut no informative data Larval Hindgut    7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.375 Larval Carcass no informative data Adult Head    33.3 Adult Eye no informative data Adult Brain    8.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    7.025 Larval Midgut no informative data Larval Hindgut    7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.375 Larval Carcass no informative data Adult Head    33.3 Adult Eye no informative data Adult Brain    8.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    7.025 Larval Midgut no informative data Larval Hindgut    7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.375 Larval Carcass no informative data Adult Head    33.3 Adult Eye no informative data Adult Brain    8.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0013812 expression level Tissue   Expression Level Larval Central Nervous System    7.025 Larval Midgut no informative data Larval Hindgut    7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.375 Larval Carcass no informative data Adult Head    33.3 Adult Eye no informative data Adult Brain    8.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    7.025 Larval Midgut no informative data Larval Hindgut    7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.375 Larval Carcass no informative data Adult Head    33.3 Adult Eye no informative data Adult Brain    8.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    7.025 Larval Midgut no informative data Larval Hindgut    7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.375 Larval Carcass no informative data Adult Head    33.3 Adult Eye no informative data Adult Brain    8.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    7.025 Larval Midgut no informative data Larval Hindgut    7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea    7.375 Larval Carcass no informative data Adult Head    33.3 Adult Eye no informative data Adult Brain    8.1 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.75 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary    3.6 Adult Testis    1.9 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea     Larval Carcass no informative data Adult Head     Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    33.3   NA  Eye    no informative data   NA  Brain    8.1   7.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    no informative data   no informative data  Midgut    no informative data   7  Hindgut    no informative data   no informative data  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    8.75   7.375  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    3.6   NA  Testis    1.9   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_24
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013812 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3723-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Dhc93ABGD11054 Phenotype manifest in Allele
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Dhc93AB Class Mutagen Stocks Known lesion Dhc93ABMB04366 1 -- Dhc93ABMB05444 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Dhc93AB Class Mutagen Stocks Known lesion Dhc93ABGD11054 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Dhc93ABKK100610 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6272 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11054} NA P{KK100610} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}Dhc93ABMB04366 No Mi{ET1}Dhc93ABMB05444 No
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
ATPase activity inferred from electronic annotation with InterPro:IPR011704 (FlyBase Curators et al., 2004-) ATPase activity, coupled inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) ATP binding inferred from electronic annotation with InterPro:IPR011704 (FlyBase Curators et al., 2004-) microtubule motor activity inferred from electronic annotation with InterPro:IPR004273 (FlyBase Curators et al., 2004-) motor activity inferred from sequence or structural similarity with Saccharomyces DYN1 (FlyBase, 1992-)
Biological Process
CV term Evidence References
microtubule-based movement inferred from electronic annotation with InterPro:IPR004273 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000)
Cellular Component
CV term Evidence References
axonemal dynein complex inferred from sequence or structural similarity with EMBL:Z83813 (FlyBase, 1992-) microtubule associated complex inferred from sequence or structural similarity (Goldstein and Gunawardena, 2000) inferred from sequence or structural similarity with Saccharomyces DYN1 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Dhc93AB allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0013812 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42485
Orthologs
Genome-wide drosophilid orthologs	Dana\GF18527 Dere\GG15004 Dgri\GH23208 Dmoj\GI10310 Dper\GL12690 Dpse\GA17641 Dsec\GM15114 Dsim\GD20019 Dvir\GJ10164
Curated drosophilid orthologs	Dhyd\Dhc3 (Kurek et al., 1998) Dpse\GA17641
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008855-PA Aedes aegypti (mosquito) AGAP010435-PA Anopheles gambiae (mosquito) XP_623957.2 Apis mellifera (honey bee) XP_001949713.1 Acyrthosiphon pisum (pea aphid) 27665 Batrachochytrium dendrobatidis (chytrid fungus) 275161 Branchiostoma floridae (lancelet) BGIBMGA003622-PA Bombyx mori (silk worm) ENSBTAP00000022637 Bos taurus (bovine) ENSCAFP00000008144 Canis familiaris (dog) ENSCINP00000011857 Ciona intestinalis (sea squirt) CPIJ011172 Culex pipens (mosquito) ENSCPOP00000009532 Cavia porcellus (guinea pig) 24252 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000018025 Ciona savignyi (sedentary tunicate) 175142 Capitella spl (polychaete worm) 309044 Daphnia pulex (daphnia) ENSDARP00000041556 Danio rerio (zebra fish) ENSECAP00000005587 Equus caballus (horse) ENSGACP00000003028 Gymnopilus aculeatus (mushroom) ENSGALP00000038608 Gallus gallus (chicken) 155577 Hypsipyla robusta (cedar shoot borer) ENSP00000300671 Homo sapiens (human) 230271 Lottia gigantea (owl limpet) LmjF13.1650 Leishmania major (virus) 8849 Monocosta brevicollis (choanoflagellate) ENSMODP00000002386 Monodelphis domestica (gray opossum) ENSMMUP00000029903 Macaca mulatta (rhesus monkey) ENSMUSP00000079494 Mus musculus (house mouse) 159788 Nematostella vectensis (starlet anemone) XP_001600478.1 Nasonia vitripennis (wasp) ENSORLP00000018220 Oryzias latipes (japanese killifish) PHUM001392-PA Pediculus humanus (human body louse) ENSPPYP00000008984 Pongo pygmaeus (orangutan) 95148 Phytophthora ramorum (sudden oak death pathogen) 108230 Phytophthora sojae (root rot pathogen) ENSPTRP00000052909 Pan troglodytes (chimpanzee) PVX_111560 Plasmodium vivax (protozoal parasite) ENSRNOP00000007233 Rattus norvegicus (norway rat) Smp_158760 Schistosoma mansoni (trematode parasite) XP_786200.2 Strongylocentrotus purpuratus (purple sea urchin) 20411 Trichoplax adhaerens (metazoa) XP_971055.2 Tribolium castaneum (red flour beetle) Tc00.1047053509585.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009594 Tetraodon nigroviridis (green spotted pufferfish) 40445 Thalassiosira pseudonana (marine diatom) ENSTRUP00000010597 Takifugu rubripes (pufferfish Takifugu) 3716.m00005 Tetrahymena thermophila (ciliate protozoa) 97417.m00090 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000016372 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50157 LH21322 FBgn0242113 FBgn0214180 FBgn0197452 FBgn0191501 FBgn0186760 FBgn0170034 JGI_V11_309044 FBgn0077652 FBgn0150296 FBgn0133075 FBgn0130665 FBgn0107258 FBgn0095545 CPIJ011172 BGIBMGA005048 BGIBMGA003622 ACYPI007802 ACYPI006684 ACYPI005898 GB10147 AGAP010435 AAEL008855 PB19929 PHUM285280 GLEAN_10846
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	24697 w1118; Mi{ET1}Dhc93ABMB04366 25298 w1118; Mi{ET1}Dhc93ABMB05444
VDRC	v108658 P{KK100610}VIE-260B v41947 w1118; P{GD11054}v41947/TM3
Genomic Clones ( 1 )
	BACR05I01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 3 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	MB6-CG3723.a MB6-CG3723.a MB6-CG3723.a
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0013812 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42485
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Dhc93AB CG3723 (Gong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Spindle pole movements in embryos are directed by a temporally coordinated balance of forces generated by three mitotic motors; cytoplasmic dynein, Klp61F and ncd. Dynein acts to move the poles apart throughout mitosis, and this activity is augmented by Klp61F after the fenestration of the nuclear envelope, which occurs at the onset of prometaphase. ncd generates forces that pull the poles together between interphase and metaphase, antagonising the activity of both cytoplasmic dynein and Klp61F and serving as a brake for spindle assembly. (Sharp et al., 2000) Identification: PCR screen for Dynein heavy chain genes. (Kurek et al., 1998) Dhc93AB has been cloned and characterised. (Rasmusson et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079700 RefSeq (Proteins) • NP_524424 DDBJ / EMBL / GenBank • AAA52090 AAF55834 L23198 Entrez Gene - A searchable database of RefSeq genes. • 42485 UniProtKB/TrEMBL • Q9VDG0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Dynein heavy chain (IPR004273) ATPase, dynein-related, AAA domain (IPR011704) Dynein heavy chain, domain-2 (IPR013602) ATPase, AAA+ type, core (IPR003593) Dynein heavy chain, P-loop containing D4 domain (IPR024317) Dynein heavy chain, coiled coil stalk (IPR024743) Dynein heavy chain, domain-1 (IPR013594)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0013812 DRSC - Results from RNAi screens. • FBgn0013812 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013812 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3723-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0013812 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42485 InParanoid A subset of ortholog calls from InParanoid. • AAEL008855-PA Aedes aegypti (mosquito) AGAP010435-PA Anopheles gambiae (mosquito) XP_623957.2 Apis mellifera (honey bee) XP_001949713.1 Acyrthosiphon pisum (pea aphid) 27665 Batrachochytrium dendrobatidis (chytrid fungus) 275161 Branchiostoma floridae (lancelet) BGIBMGA003622-PA Bombyx mori (silk worm) ENSBTAP00000022637 Bos taurus (bovine) ENSCAFP00000008144 Canis familiaris (dog) ENSCINP00000011857 Ciona intestinalis (sea squirt) CPIJ011172 Culex pipens (mosquito) ENSCPOP00000009532 Cavia porcellus (guinea pig) 24252 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000018025 Ciona savignyi (sedentary tunicate) 175142 Capitella spl (polychaete worm) 309044 Daphnia pulex (daphnia) ENSDARP00000041556 Danio rerio (zebra fish) ENSECAP00000005587 Equus caballus (horse) ENSGACP00000003028 Gymnopilus aculeatus (mushroom) ENSGALP00000038608 Gallus gallus (chicken) 155577 Hypsipyla robusta (cedar shoot borer) ENSP00000300671 Homo sapiens (human) 230271 Lottia gigantea (owl limpet) LmjF13.1650 Leishmania major (virus) 8849 Monocosta brevicollis (choanoflagellate) ENSMODP00000002386 Monodelphis domestica (gray opossum) ENSMMUP00000029903 Macaca mulatta (rhesus monkey) ENSMUSP00000079494 Mus musculus (house mouse) 159788 Nematostella vectensis (starlet anemone) XP_001600478.1 Nasonia vitripennis (wasp) ENSORLP00000018220 Oryzias latipes (japanese killifish) PHUM001392-PA Pediculus humanus (human body louse) ENSPPYP00000008984 Pongo pygmaeus (orangutan) 95148 Phytophthora ramorum (sudden oak death pathogen) 108230 Phytophthora sojae (root rot pathogen) ENSPTRP00000052909 Pan troglodytes (chimpanzee) PVX_111560 Plasmodium vivax (protozoal parasite) ENSRNOP00000007233 Rattus norvegicus (norway rat) Smp_158760 Schistosoma mansoni (trematode parasite) XP_786200.2 Strongylocentrotus purpuratus (purple sea urchin) 20411 Trichoplax adhaerens (metazoa) XP_971055.2 Tribolium castaneum (red flour beetle) Tc00.1047053509585.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000009594 Tetraodon nigroviridis (green spotted pufferfish) 40445 Thalassiosira pseudonana (marine diatom) ENSTRUP00000010597 Takifugu rubripes (pufferfish Takifugu) 3716.m00005 Tetrahymena thermophila (ciliate protozoa) 97417.m00090 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000016372 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42485 modMine - Data generated by the modENCODE project. • FBgn0013812 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50157 LH21322 FBgn0242113 FBgn0214180 FBgn0197452 FBgn0191501 FBgn0186760 FBgn0170034 JGI_V11_309044 FBgn0077652 FBgn0150296 FBgn0133075 FBgn0130665 FBgn0107258 FBgn0095545 CPIJ011172 BGIBMGA005048 BGIBMGA003622 ACYPI007802 ACYPI006684 ACYPI005898 GB10147 AGAP010435 AAEL008855 PB19929 PHUM285280 GLEAN_10846
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	CG3723 (Buenemann, 2002.3.21, Goldstein and Gunawardena, 2000, Przewloka et al., 2007, Keleman et al., 2009.8.5) dhc (Basto et al., 2004) DHC (Cytrynbaum et al., 2003, Sharp et al., 2000) Dhc (Johnstone and Lasko, 2001, Starr et al., 1998) Dhc93AB (Dorus et al., 2006, Junion et al., 2007, Wasbrough et al., 2010) Dhc 93AB (Diaz-Castillo and Golic, 2007) unnamed (Goldstein and Gunawardena, 2000)
Name Synonym	Dynein heavy chain at 93AB   dynein-related heavy chain polypeptide (Li, 1993)
Secondary FlyBase IDs
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 9 ) Supplementary material  ( 7 ) Review  ( 2 ) Personal communication to FlyBase  ( 7 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 2 ) Automatic genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
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