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Gene Dmel\PR2

General Information
Symbol	Dmel\PR2	Species	D. melanogaster
Name	Fak-like tyrosine kinase	Annotation symbol	CG3969
Feature type	protein_coding_gene	FlyBase ID	FBgn0013955
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	DPR2, DmHD-11, dACK
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	49F3-49F4	Sequence location	2R:9,030,337..9,040,161 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Fak-like tyrosine kinase is referred to in FlyBase by the symbol Dmel\PR2 (CG3969, FBgn0013955). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process: autophagic cell death; salivary gland cell autophagic cell death. 6 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: PAK-box/P21-Rho-binding; Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase; Src homology-3 domain; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1637111_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of PR2. Gene sequence location is 2R:9030337..9040161.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN50653 BKN24274 BKN51131 HFA07500
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 49F3-49F4   Limits computationally determined from genome sequence between P{lacW}Psck07834&P{lacW}Su(z)2k06344 and P{EP}EP873EP873
Experimentally Determined Cytological Location
Cytogenetic map Notes References 31F1-31F2   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\PR2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) PR2-RA FBtr0087776  NM_057738   4342   1337 PR2-RB FBtr0087777  NM_057739   4403   1255
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein PR2-PA   FBpp0086889   147.5   1337   6.56     NP_477086   AAG22275 PR2-PB   FBpp0086890   137.6   1255   6.42     NP_477087   AAF58423
Additional Polypeptide Data & Comments
Reported size (kDa)	765 (aa) (Ito et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • PAK-box/P21-Rho-binding (IPR000095) Protein kinase, catalytic domain (IPR000719) Src homology-3 domain (IPR001452) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA801747   AA950417   AE013599 AAF58423   AE013599 AAG22275   AC005471   AI063225   AI063915   AI064476   AI292527   AI386955   AI387492   AI541822   AI542847   AJ002909 CAA05744   AW942921   AY051755 AAK93179   BF499071   BG632076   BI575228   BI583688   BI584691   BI586367   BI587504   BI638809   CO189653   CO190646   CO193369   CO266350   CO286108   CO289382   CO302085   CO302108   CO325441   CO330555   CZ467973   D17551 BAA04489   EC052000   EC053529   EC054016   EC062825   EC073029   EC078974   EC085472   EC090453   EC195448   EC198440   EC200048   EC212278   EC241361   EC241783   EC242167   EC245497   EV584159   GH941125   GH944900   GH947975   GH950676   GH960096   GH962019   GH964225   GH970748   GH975098   GH975774   GH979517   GH980397   GH981485   GH981569   GH982871   GH984458
UniProtKB/Swiss-Prot	Q9I7F7
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0013955    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0013955 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0013955 expression level Developmental Stage   Expression Level embryo 00-02hr    2392 embryo 02-04hr    855 embryo 04-06hr    1719 embryo 06-08hr    2444 embryo 08-10hr    2597 embryo 10-12hr    2281 embryo 12-14hr    2449 embryo 14-16hr    1698 embryo 16-18hr    904 embryo 18-20hr    533 embryo 20-22hr    322 embryo 22-24hr    415 larva L1    458 larva L2    406 larva L3 12hr old    397 larva L3 puffstage 1-2    725 larva L3 puffstage 3-6    1275 larva L3 puffstage 7-9    2063 white prepupae new    2259 white prepupae 12hr    3071 white prepupae 24hr    2556 pupae 2d postWPP    1242 pupae 3d postWPP    589 pupae 4d postWPP    389 adult male 01day    435 adult male 05day    546 adult male 30day    485 adult female 01day    877 adult female 05day    1599 adult female 30day    1647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2392) embryo 02-04hr  (855) embryo 04-06hr  (1719) embryo 06-08hr  (2444) embryo 08-10hr  (2597) embryo 10-12hr  (2281) embryo 12-14hr  (2449) embryo 14-16hr  (1698) embryo 16-18hr  (904) embryo 18-20hr  (533) embryo 20-22hr  (322) embryo 22-24hr  (415) larva L1  (458) larva L2  (406) larva L3 12hr old  (397) larva L3 puffstage 1-2  (725) larva L3 puffstage 3-6  (1275) larva L3 puffstage 7-9  (2063) white prepupae new  (2259) white prepupae 12hr  (3071) white prepupae 24hr  (2556) pupae 2d postWPP  (1242) pupae 3d postWPP  (589) pupae 4d postWPP  (389) adult male 01day  (435) adult male 05day  (546) adult male 30day  (485) adult female 01day  (877) adult female 05day  (1599) adult female 30day  (1647) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2392) embryo 02-04hr    855 embryo 04-06hr  (1719) embryo 06-08hr  (2444) embryo 08-10hr  (2597) embryo 10-12hr  (2281) embryo 12-14hr  (2449) embryo 14-16hr  (1698) embryo 16-18hr    904 embryo 18-20hr    533 embryo 20-22hr    322 embryo 22-24hr    415 larva L1    458 larva L2    406 larva L3 12hr old    397 larva L3 puffstage 1-2    725 larva L3 puffstage 3-6    1275 larva L3 puffstage 7-9  (2063) white prepupae new  (2259) white prepupae 12hr  (3071) white prepupae 24hr  (2556) pupae 2d postWPP    1242 pupae 3d postWPP    589 pupae 4d postWPP    389 adult male 01day    435 adult male 05day    546 adult male 30day    485 adult female 01day    877 adult female 05day  (1599) adult female 30day  (1647) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2392 embryo 02-04hr    855 embryo 04-06hr    1719 embryo 06-08hr    2444 embryo 08-10hr    2597 embryo 10-12hr    2281 embryo 12-14hr    2449 embryo 14-16hr    1698 embryo 16-18hr    904 embryo 18-20hr    533 embryo 20-22hr    322 embryo 22-24hr    415 larva L1    458 larva L2    406 larva L3 12hr old    397 larva L3 puffstage 1-2    725 larva L3 puffstage 3-6    1275 larva L3 puffstage 7-9    2063 white prepupae new    2259 white prepupae 12hr    3071 white prepupae 24hr    2556 pupae 2d postWPP    1242 pupae 3d postWPP    589 pupae 4d postWPP    389 adult male 01day    435 adult male 05day    546 adult male 30day    485 adult female 01day    877 adult female 05day    1599 adult female 30day    1647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2392 embryo 02-04hr    855 embryo 04-06hr    1719 embryo 06-08hr    2444 embryo 08-10hr    2597 embryo 10-12hr    2281 embryo 12-14hr    2449 embryo 14-16hr    1698 embryo 16-18hr    904 embryo 18-20hr    533 embryo 20-22hr    322 embryo 22-24hr    415 larva L1    458 larva L2    406 larva L3 12hr old    397 larva L3 puffstage 1-2    725 larva L3 puffstage 3-6    1275 larva L3 puffstage 7-9    2063 white prepupae new    2259 white prepupae 12hr    3071 white prepupae 24hr    2556 pupae 2d postWPP    1242 pupae 3d postWPP    589 pupae 4d postWPP    389 adult male 01day    435 adult male 05day    546 adult male 30day    485 adult female 01day    877 adult female 05day    1599 adult female 30day    1647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0013955 expression level Developmental Stage   Expression Level embryo 00-02hr    2392 embryo 02-04hr    855 embryo 04-06hr    1719 embryo 06-08hr    2444 embryo 08-10hr    2597 embryo 10-12hr    2281 embryo 12-14hr    2449 embryo 14-16hr    1698 embryo 16-18hr    904 embryo 18-20hr    533 embryo 20-22hr    322 embryo 22-24hr    415 larva L1    458 larva L2    406 larva L3 12hr old    397 larva L3 puffstage 1-2    725 larva L3 puffstage 3-6    1275 larva L3 puffstage 7-9    2063 white prepupae new    2259 white prepupae 12hr    3071 white prepupae 24hr    2556 pupae 2d postWPP    1242 pupae 3d postWPP    589 pupae 4d postWPP    389 adult male 01day    435 adult male 05day    546 adult male 30day    485 adult female 01day    877 adult female 05day    1599 adult female 30day    1647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2392) embryo 02-04hr  (855) embryo 04-06hr  (1719) embryo 06-08hr  (2444) embryo 08-10hr  (2597) embryo 10-12hr  (2281) embryo 12-14hr  (2449) embryo 14-16hr  (1698) embryo 16-18hr  (904) embryo 18-20hr  (533) embryo 20-22hr  (322) embryo 22-24hr  (415) larva L1  (458) larva L2  (406) larva L3 12hr old  (397) larva L3 puffstage 1-2  (725) larva L3 puffstage 3-6  (1275) larva L3 puffstage 7-9  (2063) white prepupae new  (2259) white prepupae 12hr  (3071) white prepupae 24hr  (2556) pupae 2d postWPP  (1242) pupae 3d postWPP  (589) pupae 4d postWPP  (389) adult male 01day  (435) adult male 05day  (546) adult male 30day  (485) adult female 01day  (877) adult female 05day  (1599) adult female 30day  (1647) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2392 embryo 02-04hr    855 embryo 04-06hr  1719 embryo 06-08hr  2444 embryo 08-10hr  (2597) embryo 10-12hr  2281 embryo 12-14hr  2449 embryo 14-16hr  1698 embryo 16-18hr    904 embryo 18-20hr    533 embryo 20-22hr    322 embryo 22-24hr    415 larva L1    458 larva L2    406 larva L3 12hr old    397 larva L3 puffstage 1-2    725 larva L3 puffstage 3-6    1275 larva L3 puffstage 7-9  2063 white prepupae new  2259 white prepupae 12hr  (3071) white prepupae 24hr  (2556) pupae 2d postWPP    1242 pupae 3d postWPP    589 pupae 4d postWPP    389 adult male 01day    435 adult male 05day    546 adult male 30day    485 adult female 01day    877 adult female 05day  1599 adult female 30day  1647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2392 embryo 02-04hr    855 embryo 04-06hr    1719 embryo 06-08hr    2444 embryo 08-10hr    2597 embryo 10-12hr    2281 embryo 12-14hr    2449 embryo 14-16hr    1698 embryo 16-18hr    904 embryo 18-20hr    533 embryo 20-22hr    322 embryo 22-24hr    415 larva L1    458 larva L2    406 larva L3 12hr old    397 larva L3 puffstage 1-2    725 larva L3 puffstage 3-6    1275 larva L3 puffstage 7-9    2063 white prepupae new    2259 white prepupae 12hr    3071 white prepupae 24hr    2556 pupae 2d postWPP    1242 pupae 3d postWPP    589 pupae 4d postWPP    389 adult male 01day    435 adult male 05day    546 adult male 30day    485 adult female 01day    877 adult female 05day    1599 adult female 30day    1647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2392 embryo 02-04hr    855 embryo 04-06hr    1719 embryo 06-08hr    2444 embryo 08-10hr    2597 embryo 10-12hr    2281 embryo 12-14hr    2449 embryo 14-16hr    1698 embryo 16-18hr    904 embryo 18-20hr    533 embryo 20-22hr    322 embryo 22-24hr    415 larva L1    458 larva L2    406 larva L3 12hr old    397 larva L3 puffstage 1-2    725 larva L3 puffstage 3-6    1275 larva L3 puffstage 7-9    2063 white prepupae new    2259 white prepupae 12hr    3071 white prepupae 24hr    2556 pupae 2d postWPP    1242 pupae 3d postWPP    589 pupae 4d postWPP    389 adult male 01day    435 adult male 05day    546 adult male 30day    485 adult female 01day    877 adult female 05day    1599 adult female 30day    1647 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0013955    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0013955 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, adult female reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0013955 expression level Tissue   Expression Level Larval Central Nervous System    314.775 Larval Midgut    61.6 Larval Hindgut    121 Larval Malpighian Tubules    191.3 Larval Fat Body    126 Larval Salivary Gland    84.1 Larval Trachea    313.975 Larval Carcass    144.6 Adult Head    52.4 Adult Eye    48.675 Adult Brain    27.2 Adult Thoracic-Abdominal Ganglion    38.8 Adult Crop    137.7 Adult Midgut    60.9 Adult Hindgut    89.7 Adult Malpighian Tubules    115 Adult Fat Body    143 Adult Salivary Gland    81.9 Adult Heart    105.775 Adult VirginFemale Spermatheca    98.3 Adult InseminatedFemale Spermatheca    111.7 Adult Ovary    253.4 Adult Testis    82.9 Adult Male Accessory Gland    71.2 Adult Carcass    69.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    314.775 Larval Midgut    61.6 Larval Hindgut    121 Larval Malpighian Tubules    191.3 Larval Fat Body    126 Larval Salivary Gland    84.1 Larval Trachea    313.975 Larval Carcass    144.6 Adult Head    52.4 Adult Eye    48.675 Adult Brain    27.2 Adult Thoracic-Abdominal Ganglion    38.8 Adult Crop    137.7 Adult Midgut    60.9 Adult Hindgut    89.7 Adult Malpighian Tubules    115 Adult Fat Body    143 Adult Salivary Gland    81.9 Adult Heart    105.775 Adult VirginFemale Spermatheca    98.3 Adult InseminatedFemale Spermatheca    111.7 Adult Ovary    253.4 Adult Testis    82.9 Adult Male Accessory Gland    71.2 Adult Carcass    69.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    314.775 Larval Midgut    61.6 Larval Hindgut    121 Larval Malpighian Tubules    191.3 Larval Fat Body    126 Larval Salivary Gland    84.1 Larval Trachea    313.975 Larval Carcass    144.6 Adult Head    52.4 Adult Eye    48.675 Adult Brain    27.2 Adult Thoracic-Abdominal Ganglion    38.8 Adult Crop    137.7 Adult Midgut    60.9 Adult Hindgut    89.7 Adult Malpighian Tubules    115 Adult Fat Body    143 Adult Salivary Gland    81.9 Adult Heart    105.775 Adult VirginFemale Spermatheca    98.3 Adult InseminatedFemale Spermatheca    111.7 Adult Ovary    253.4 Adult Testis    82.9 Adult Male Accessory Gland    71.2 Adult Carcass    69.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    314.775 Larval Midgut    61.6 Larval Hindgut    121 Larval Malpighian Tubules    191.3 Larval Fat Body    126 Larval Salivary Gland    84.1 Larval Trachea    313.975 Larval Carcass    144.6 Adult Head    52.4 Adult Eye    48.675 Adult Brain    27.2 Adult Thoracic-Abdominal Ganglion    38.8 Adult Crop    137.7 Adult Midgut    60.9 Adult Hindgut    89.7 Adult Malpighian Tubules    115 Adult Fat Body    143 Adult Salivary Gland    81.9 Adult Heart    105.775 Adult VirginFemale Spermatheca    98.3 Adult InseminatedFemale Spermatheca    111.7 Adult Ovary    253.4 Adult Testis    82.9 Adult Male Accessory Gland    71.2 Adult Carcass    69.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0013955 expression level Tissue   Expression Level Larval Central Nervous System    314.775 Larval Midgut    61.6 Larval Hindgut    121 Larval Malpighian Tubules    191.3 Larval Fat Body    126 Larval Salivary Gland    84.1 Larval Trachea    313.975 Larval Carcass    144.6 Adult Head    52.4 Adult Eye    48.675 Adult Brain    27.2 Adult Thoracic-Abdominal Ganglion    38.8 Adult Crop    137.7 Adult Midgut    60.9 Adult Hindgut    89.7 Adult Malpighian Tubules    115 Adult Fat Body    143 Adult Salivary Gland    81.9 Adult Heart    105.775 Adult VirginFemale Spermatheca    98.3 Adult InseminatedFemale Spermatheca    111.7 Adult Ovary    253.4 Adult Testis    82.9 Adult Male Accessory Gland    71.2 Adult Carcass    69.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    314.775 Larval Midgut    61.6 Larval Hindgut    121 Larval Malpighian Tubules    191.3 Larval Fat Body    126 Larval Salivary Gland    84.1 Larval Trachea    313.975 Larval Carcass    144.6 Adult Head    52.4 Adult Eye    48.675 Adult Brain    27.2 Adult Thoracic-Abdominal Ganglion    38.8 Adult Crop    137.7 Adult Midgut    60.9 Adult Hindgut    89.7 Adult Malpighian Tubules    115 Adult Fat Body    143 Adult Salivary Gland    81.9 Adult Heart    105.775 Adult VirginFemale Spermatheca    98.3 Adult InseminatedFemale Spermatheca    111.7 Adult Ovary    253.4 Adult Testis    82.9 Adult Male Accessory Gland    71.2 Adult Carcass    69.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    314.775 Larval Midgut    61.6 Larval Hindgut    121 Larval Malpighian Tubules    191.3 Larval Fat Body    126 Larval Salivary Gland    84.1 Larval Trachea    313.975 Larval Carcass    144.6 Adult Head    52.4 Adult Eye    48.675 Adult Brain    27.2 Adult Thoracic-Abdominal Ganglion    38.8 Adult Crop    137.7 Adult Midgut    60.9 Adult Hindgut    89.7 Adult Malpighian Tubules    115 Adult Fat Body    143 Adult Salivary Gland    81.9 Adult Heart    105.775 Adult VirginFemale Spermatheca    98.3 Adult InseminatedFemale Spermatheca    111.7 Adult Ovary    253.4 Adult Testis    82.9 Adult Male Accessory Gland    71.2 Adult Carcass    69.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    314.775 Larval Midgut    61.6 Larval Hindgut    121 Larval Malpighian Tubules    191.3 Larval Fat Body    126 Larval Salivary Gland    84.1 Larval Trachea    313.975 Larval Carcass    144.6 Adult Head    52.4 Adult Eye    48.675 Adult Brain    27.2 Adult Thoracic-Abdominal Ganglion    38.8 Adult Crop    137.7 Adult Midgut    60.9 Adult Hindgut    89.7 Adult Malpighian Tubules    115 Adult Fat Body    143 Adult Salivary Gland    81.9 Adult Heart    105.775 Adult VirginFemale Spermatheca    98.3 Adult InseminatedFemale Spermatheca    111.7 Adult Ovary    253.4 Adult Testis    82.9 Adult Male Accessory Gland    71.2 Adult Carcass    69.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    52.4   NA  Eye    48.675   NA  Brain    27.2   314.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    38.8   NA  Crop    137.7   61.6  Midgut    60.9   121  Hindgut    89.7   191.3  Malpighian Tubules    115   126  Fat Body    143   84.1  Salivary Gland    81.9   NA  Heart    105.775   313.975  Trachea    NA   NA  VirginFemale Spermatheca    98.3   NA  InseminatedFemale Spermatheca    111.7   NA  Ovary    253.4   NA  Testis    82.9   NA  Male Accessory Gland    71.2   144.6  Carcass    69.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_30
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013955 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3969-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for PR2 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 PR2GD10698 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 PR2GD10698 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 PR2GD10698
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of PR2 Class Mutagen Stocks Known lesion PR2c02472 piggyBac transposase 1 -- PR2MB05119 1 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of PR2 Class Mutagen Stocks Known lesion PR2GD10698 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PR2GL00190 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PR2JF03110 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes PR2KK105138 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel8057 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10698} NA P{KK105138} NA P{TRiP.GL00190} NA P{TRiP.JF03110} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{wHy}TppIIDG14110 NA PBac{PB}PR2c02472 NA insertion of enhancer trap binary system Mi{ET1}PR2MB05119 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
	There is no information supporting a cellular component term for this gene. (Based on a review of available data on: 2006-10-26)
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
autophagic cell death inferred from expression pattern (Gorski et al., 2003) salivary gland cell autophagic cell death inferred from expression pattern (Gorski et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441 (FlyBase Curators et al., 2004-) non-membrane spanning protein tyrosine kinase activity inferred from sequence or structural similarity with EMBL:AF037260 (FlyBase, 1992-) protein tyrosine kinase activity inferred from sequence or structural similarity (Ito et al., 1994) non-traceable author statement (Oates, 1997.11.10, Morrison et al., 2000) non-traceable author statement (assigned by UniProtKB) (Oates et al., 1998)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266, InterPro:IPR020635 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Ito et al., 1994) non-traceable author statement (Morrison et al., 2000) non-traceable author statement (assigned by UniProtKB) (Oates et al., 1998)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions PR2 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0013955
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011046-PA Aedes aegypti (mosquito) AGAP007715-PA Anopheles gambiae (mosquito) XP_624955.1 Apis mellifera (honey bee) XP_001948239.1 Acyrthosiphon pisum (pea aphid) 119917 Branchiostoma floridae (lancelet) 124170 Branchiostoma floridae (lancelet) RP43332 Caenorhabditis remanei (nematode) 228268 Capitella spl (polychaete worm) 300082 Daphnia pulex (daphnia) ENSECAP00000001254 Equus caballus (horse) ISCW020028-PA Ixodes scapularis (deer tick) 217379 Nematostella vectensis (starlet anemone) XP_001607731.1 Nasonia vitripennis (wasp) PHUM000396-PA Pediculus humanus (human body louse) PP13430 Pristionchus pacificus (nematode) XP_975205.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10334 ISCW020028 FBgn0231077 FBgn0223626 FBgn0208271 FBgn0201874 FBgn0197071 FBgn0175195 JGI_V11_300082 FBgn0245812 FBgn0148195 FBgn0142299 FBgn0129052 FBgn0114698 FBgn0089021 BGIBMGA012318 ACYPI009460 GB15300 AGAP007715 AAEL011046 PHUM216720 GLEAN_14734
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	28694 y1 v1; P{TRiP.JF03110}attP2 35288 y1 sc* v1; P{TRiP.GL00190}attP2 24322 w1118; Mi{ET1}PR2MB05119 PR2MB05119
Harvard	- PBac{PB}PR2c02472
VDRC	v100169 P{KK105138}VIE-260B v26065 w1118; P{GD10698}v26065
Genomic Clones ( 1 )
	BACR48I10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 60 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD28966
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT13558 GH04032 GH04915 GH15450 GH17348 GH18037 GM03442 RH22353 RH23948 RH26309 RH28192 RH29752 SD07621 SD21195
Other clones	29584 35412 45593 55183 55217 59121 69399 192886 194824 CK01.55C.G7 CK01.60D.B6 CK01.79C.E8 CK01.90B.D1 Dmel_dig_011524_0661_0949 EC35668 EC052000 EC053529 EC054016 EK044828 EK048930 EK061752 EK070913 EK146127 EK183025 EK183061 EK196525 EK295540 GH02782 RP004174526 RP004197725 RP004202920 RP004216633 RP004230535 RP004230852 RP004235500 RP004241454 RP004249980 RP004270540 RP004334569 RP004349927 RP004422906 RP004506149 RP004530065 RP004549413 SD09337
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0013955 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36442
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments	Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known. (Oates, 1997.11.10)
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Isolated from a genomic library using a cDNA fragment encoding the human β-platelet derived growth factor receptor tyrosine kinase domain as a probe, under low stringency conditions. (Ito et al., 1994) PR2 has been cloned and sequenced. (Ito et al., 1994)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057738 NM_057739 RefSeq (Proteins) • NP_477086 NP_477087 DDBJ / EMBL / GenBank • AA950417 AAF58423 AAG22275 AAK93179 AC005471 AI387492 AJ002909 AW942921 AY051755 BAA04489 CAA05744 CZ467973 D17551 Entrez Gene - A searchable database of RefSeq genes. • 36442 UniProtKB/Swiss-Prot • Q9I7F7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • PAK-box/P21-Rho-binding (IPR000095) Protein kinase, catalytic domain (IPR000719) Src homology-3 domain (IPR001452) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase (IPR001245)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0013955 DRSC - Results from RNAi screens. • FBgn0013955 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0013955 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3969-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0013955 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36442 InParanoid A subset of ortholog calls from InParanoid. • AAEL011046-PA Aedes aegypti (mosquito) AGAP007715-PA Anopheles gambiae (mosquito) XP_624955.1 Apis mellifera (honey bee) XP_001948239.1 Acyrthosiphon pisum (pea aphid) 119917 Branchiostoma floridae (lancelet) 124170 Branchiostoma floridae (lancelet) RP43332 Caenorhabditis remanei (nematode) 228268 Capitella spl (polychaete worm) 300082 Daphnia pulex (daphnia) ENSECAP00000001254 Equus caballus (horse) ISCW020028-PA Ixodes scapularis (deer tick) 217379 Nematostella vectensis (starlet anemone) XP_001607731.1 Nasonia vitripennis (wasp) PHUM000396-PA Pediculus humanus (human body louse) PP13430 Pristionchus pacificus (nematode) XP_975205.1 Tribolium castaneum (red flour beetle) modMine - Data generated by the modENCODE project. • FBgn0013955 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10334 ISCW020028 FBgn0231077 FBgn0223626 FBgn0208271 FBgn0201874 FBgn0197071 FBgn0175195 JGI_V11_300082 FBgn0245812 FBgn0148195 FBgn0142299 FBgn0129052 FBgn0114698 FBgn0089021 BGIBMGA012318 ACYPI009460 GB15300 AGAP007715 AAEL011046 PHUM216720 GLEAN_14734
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG3969 (Morrison et al., 2000, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2011.7.19) dACK (Burbelo, 2001.7.27, Pirone et al., 2001) DmHD-11 (Oates, 1997.11.10, Oates et al., 1998) DPR2 (Zahedi et al., 2004, Burbelo et al., 1995, Ito et al., 1994, Shen et al., 2006) DRODPR2 (Oates et al., 1998) HD-11   PR2 (Jager et al., 2005, Zahedi et al., 2008) PR2/ACK (Morrison et al., 2000) Rp2
Name Synonym	Fak-like tyrosine kinase   focal adhesion kinase (Matsui, 1993)
Secondary FlyBase IDs
	FBgn0019939 FBgn0022801
References ( 33 )
Generate a list of	All references relating to this gene ( 33 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 2 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 4 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...