FB2020_06, released Dec 22, 2020

Gene: Dmel\Ptp69D

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General Information
Symbol
Dmel\Ptp69D
Species
D. melanogaster
Name
Protein tyrosine phosphatase 69D
Annotation Symbol
CG10975
Feature Type
protein_coding_gene
FlyBase ID
FBgn0014007
Gene Model Status
Current
Stock Availability
43 publicly available
Gene Snapshot
Protein tyrosine phosphatase 69D (Ptp69D) encodes a transmembrane receptor tyrosine phosphatase (RPTP). It genetically interacts with the other RPTP genes and its mutants have embryonic motor axon guidance phenotypes. In particular, Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline. The product of Ptp69D physically and genetically interacts with the product of Dscam1 to regulate arborization of mechanosensory neurons. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

DPTP69D, DPTP

Key Links
Genomic Location
Cytogenetic map
69D6-69E1
Sequence location
3L:12,734,945..12,741,568 [+]
Recombination map

3-39

RefSeq locus
NT_037436 REGION:12734945..12741568
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (13 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables transmembrane receptor protein tyrosine phosphatase activity
inferred from direct assay
(Streuli et al., 1989)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables protein tyrosine phosphatase activity
inferred from biological aspect of ancestor with PANTHER:PTN000439233
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in axon guidance
inferred from genetic interaction with FLYBASE:sas; FB:FBgn0002306
(Lee et al., 2013)
inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370
(Lee et al., 2013)
involved_in defasciculation of motor neuron axon
inferred from mutant phenotype
(Desai et al., 1996)
inferred from genetic interaction with FLYBASE:Ptp99A; FB:FBgn0004369
(Desai et al., 1996)
involved_in dendrite morphogenesis
inferred from mutant phenotype
(Grueber et al., 2007)
involved_in fasciculation of sensory neuron axon
inferred from mutant phenotype
(Grueber et al., 2007)
involved_in motor neuron axon guidance
inferred from genetic interaction with FLYBASE:Ptp4E; FB:FBgn0004368, FLYBASE:Ptp10D; FB:FBgn0004370
(Jeon et al., 2008)
inferred from genetic interaction with FLYBASE:Ptp10D; FB:FBgn0004370
(Sun et al., 2001)
inferred from mutant phenotype
(Desai et al., 1996)
inferred from genetic interaction with FLYBASE:Ptp99A; FB:FBgn0004369
(Desai et al., 1996)
involved_in peptidyl-tyrosine dephosphorylation
inferred from direct assay
(Streuli et al., 1989)
involved_in synaptic target inhibition
inferred from mutant phenotype
(Oliva et al., 2016)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in protein dephosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN000439233
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Jeon et al., 2008)
located_in cell surface
inferred from direct assay
(Tong et al., 2011)
located_in plasma membrane
inferred from high throughput direct assay
(Lye et al., 2014, Tan et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein-tyrosine phosphatase family. Receptor class subfamily. (P16620)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
RECEPTOR PROTEIN TYROSINE PHOSPHATASES -
Receptor Protein Tyrosine Phosphatases possess a single transmembrane domain and are localized to the plasma membrane. The Protein Tyrosine Phosphatases are defined by the active-site signature motif Cys-X5-Arg. (Adapted from FBrf0129980 and PMID:17057753).
Protein Function (UniProtKB)
Possible cell adhesion receptor.
(UniProt, P16620)
Summary (Interactive Fly)

receptor tyrosine phosphatase involved in axon guidance - Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline - Ptp69D physically and genetically interacts with Dscam1 to regulate arborization of mechanosensory neurons

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Ptp69D for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ptp69D-RA
FBtr0075913
NM_079324
5168
1462
Ptp69D-RB
FBtr0075914
NM_176324
5165
1461
Additional Transcript Data and Comments
Reported size (kB)

4.477 (longest cDNA)

(Streuli et al., 1989)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ptp69D-PA
FBpp0075645
167.5
1462
6.55
NP_524048
AAF49892
Ptp69D-PB
FBpp0075646
167.4
1461
6.55
NP_788502
AAO41254
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

1462 (aa)

(Streuli et al., 1989)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ptp69D using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
lamina plexus | anterior
(Garrity et al., 1999)
lamina anlage
(Garrity et al., 1999)
medulla anlage
(Garrity et al., 1999)
embryonic/larval optic lobe
(Garrity et al., 1999)
larval stage
lamina plexus
(Garrity et al., 1999)
medulla anlage
(Garrity et al., 1999)
pupal stage P6
lamina
(Tong et al., 2011)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
day 5 of adulthood & male -- day 7 of adulthood & male
spermatozoon
(Wasbrough et al., 2010)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Ptp69D protein labels the cell surface of lamina cells in pupa.

(Tong et al., 2011)

In the third instar larval brain, Ptp69D is detected in the lamina plexus between the epithelial and marginal glia, and along the anterior edge of the lamina plexus where newly arriving R1-R6 axons terminate.

(Garrity et al., 1999)
Marker for
 
cell surface
(Tong et al., 2011)
Subcellular Localization
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Jeon et al., 2008)
located_in cell surface
inferred from direct assay
(Tong et al., 2011)
located_in plasma membrane
inferred from high throughput direct assay
(Lye et al., 2014, Tan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ptp69D in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 40 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 37 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ptp69D
Transgenic constructs containing regulatory region of Ptp69D
Deletions and Duplications ( 6 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4elav.PLu
lethal (with Df(3L)8ex34)
lethal (with Ptp69D1)
lethal (with Ptp69D4)
lethal (with Ptp69D5)
lethal (with Ptp69D6)
lethal (with Ptp69D7)
lethal (with Ptp69D8)
lethal (with Ptp69D8ex25)
lethal (with Ptp69D9)
lethal (with Ptp69D11)
lethal (with Ptp69D13)
lethal (with Ptp69D14)
lethal (with Ptp69D15)
lethal (with Ptp69D16)
lethal (with Ptp69D17)
lethal (with Ptp69D19)
lethal (with Ptp69D21)
lethal (with Ptp69D22)
lethal (with Ptp69DD1515)
lethal (with Ptp69DD1689)
lethal (with Ptp69DH24)
lethal | heat sensitive (with Df(3L)8ex34)
lethal | heat sensitive (with Ptp69D1)
lethal | heat sensitive (with Ptp69D4)
lethal | heat sensitive (with Ptp69D8ex25)
lethal | heat sensitive (with Ptp69D12)
lethal | heat sensitive (with Ptp69D18)
lethal | recessive
lethal | recessive | heat sensitive
lethal - all die before end of pupal stage | heat sensitive
partially lethal | heat sensitive (with Df(3L)8ex34)
partially lethal | heat sensitive (with Ptp69D1)
partially lethal | heat sensitive (with Ptp69D4)
partially lethal | heat sensitive (with Ptp69D8ex25)
partially lethal | heat sensitive (with Ptp69D10)
partially lethal | heat sensitive (with Ptp69D20)
partially lethal | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Sterility
Allele
female semi-sterile, with Scer\GAL4nos.PG, Scer\GAL4VP16.nos.UTR, Scer\GAL4VP16.otu
Other Phenotypes
Allele
body color defective, with Scer\GAL4pnr-MD237
neuroanatomy defective
neuroanatomy defective (with Df(3L)8ex34)
neuroanatomy defective | adult stage, with Scer\GAL4Pdf.PU
neuroanatomy defective | somatic clone | third instar larval stage
neuroanatomy defective | third instar larval stage (with Df(3L)8ex34)
planar polarity defective, with Scer\GAL4pnr-MD237
size defective | adult stage, with Scer\GAL4Pdf.PU
some die during pupal stage | heat sensitive
visible, with Scer\GAL4pnr-MD237
wild-type
Phenotype manifest in
Allele
abdominal segmental nerve
abdominal segmental nerve (with Df(3L)8ex34)
axon
axon | adult stage, with Scer\GAL4Pdf.PU
central nervous system
chaeta | supernumerary, with Scer\GAL4pnr-MD237
dendrite
dendritic arborizing neuron
dendritic tree | somatic clone | third instar larval stage
dendritic tree | third instar larval stage (with Df(3L)8ex34)
distal dendrite | third instar larval stage (with Df(3L)8ex34)
glial cell & lamina
intersegmental nerve
intersegmental nerve (with Df(3L)8ex34)
lamina plexus
larval multidendritic class IV neuron | somatic clone | third instar larval stage
larval multidendritic class IV neuron | third instar larval stage (with Df(3L)8ex34)
medulla
medulla | somatic clone
mesothoracic tergum, with Scer\GAL4pnr-MD237
photoreceptor cell & axon | somatic clone
photoreceptor cell R1 & axon
photoreceptor cell R1 & axon | somatic clone
photoreceptor cell R2 & axon
photoreceptor cell R2 & axon | somatic clone
photoreceptor cell R3 & axon
photoreceptor cell R3 & axon | somatic clone
photoreceptor cell R4 & axon
photoreceptor cell R4 & axon | somatic clone
photoreceptor cell R5 & axon
photoreceptor cell R5 & axon | somatic clone
photoreceptor cell R6 & axon
photoreceptor cell R6 & axon | somatic clone
photoreceptor cell R7 & axon | somatic clone
RP1 motor neuron (with Df(3L)8ex25)
RP3 motor neuron (with Df(3L)8ex25)
RP4 motor neuron (with Df(3L)8ex25)
RP5 motor neuron (with Df(3L)8ex25)
RP neuron & axon
s-LNv neuron | adult stage, with Scer\GAL4Pdf.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\PTPRC
6 of 15
Yes
Yes
Hsap\PTPRA
2 of 15
No
Yes
1  
Hsap\PTPRE
2 of 15
No
Yes
Hsap\PTPRD
1 of 15
No
No
Hsap\PTPRF
1 of 15
No
No
Hsap\PTPRK
1 of 15
No
No
Hsap\PTPRM
1 of 15
No
No
Hsap\PTPRQ
1 of 15
No
No
Hsap\PTPRS
1 of 15
No
No
Hsap\PTPRT
1 of 15
No
No
Hsap\PTPRU
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Ptprc
6 of 15
Yes
Yes
Mmus\Ptpra
2 of 15
No
Yes
Mmus\Ptpre
2 of 15
No
Yes
Mmus\Ptprd
1 of 15
No
No
Mmus\Ptprf
1 of 15
No
No
Mmus\Ptprk
1 of 15
No
No
Mmus\Ptprm
1 of 15
No
No
0  
Mmus\Ptprq
1 of 15
No
No
Mmus\Ptprs
1 of 15
No
No
Mmus\Ptprt
1 of 15
No
No
Mmus\Ptpru
1 of 15
No
No
Rattus norvegicus (Norway rat) (9)
Rnor\Ptprc
5 of 13
Yes
Yes
Rnor\Ptpre
2 of 13
No
Yes
Rnor\Ptpra
1 of 13
No
No
Rnor\Ptprf
1 of 13
No
No
Rnor\Ptprk
1 of 13
No
No
Rnor\Ptprm
1 of 13
No
No
Rnor\Ptprs
1 of 13
No
No
Rnor\Ptprt
1 of 13
No
Yes
Rnor\Ptpru
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (9)
Xtro\ptpra
2 of 12
Yes
Yes
Xtro\ptprc
2 of 12
Yes
Yes
Xtro\ptpre
2 of 12
Yes
Yes
Xtro\ptprd
1 of 12
No
No
Xtro\ptprf
1 of 12
No
No
Xtro\ptprk
1 of 12
No
No
Xtro\ptprm
1 of 12
No
No
Xtro\ptprs
1 of 12
No
No
Xtro\ptpru
1 of 12
No
No
Danio rerio (Zebrafish) (15)
Drer\ptprc
5 of 15
Yes
Yes
Drer\ptprea
2 of 15
No
Yes
Drer\ptpreb
2 of 15
No
Yes
Drer\si:ch1073-391i24.1
2 of 15
No
Yes
Drer\LOC101884960
1 of 15
No
Yes
Drer\ptpra
1 of 15
No
Yes
Drer\ptprdb
1 of 15
No
No
Drer\ptprd
1 of 15
No
No
Drer\ptprfa
1 of 15
No
No
Drer\ptprfb
1 of 15
No
No
Drer\ptprk
1 of 15
No
No
Drer\ptprsa
1 of 15
No
No
Drer\ptprt
1 of 15
No
No
Drer\ptprua
1 of 15
No
No
Drer\ptprub
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (19)
Cele\clr-1
8 of 15
Yes
Yes
Cele\ptp-4
2 of 15
No
No
Cele\Y71G12B.31
2 of 15
No
Yes
Cele\C33F10.8
1 of 15
No
No
Cele\eak-6
1 of 15
No
Yes
Cele\egg-4
1 of 15
No
No
Cele\egg-5
1 of 15
No
No
Cele\F20H11.4
1 of 15
No
No
Cele\F35C11.2
1 of 15
No
No
Cele\F55H12.2
1 of 15
No
Yes
Cele\F55H12.5
1 of 15
No
Yes
Cele\M04G7.2
1 of 15
No
No
Cele\M05D6.3
1 of 15
No
No
Cele\ptp-3
1 of 15
No
No
Cele\sdf-9
1 of 15
No
Yes
Cele\T04F3.3
1 of 15
No
Yes
Cele\T13H5.1
1 of 15
No
No
Cele\Y54F10BM.3
1 of 15
No
No
Cele\ZK616.65
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\PTP1
3 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\PTP1
2 of 15
Yes
No
Scer\PTP2
1 of 15
No
No
Scer\PTP3
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\pyp3
2 of 12
Yes
No
Spom\pyp1
1 of 12
No
No
Spom\pyp2
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900RW )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009821
Drosophila simulans
Dsim\GD14398
Drosophila sechellia
Dsec\GM25366
Drosophila erecta
Dere\GG15591
Drosophila yakuba
Dyak\GE21917
Drosophila ananassae
Dana\GF24693
Drosophila pseudoobscura pseudoobscura
Dpse\GA10681
Drosophila persimilis
Dper\GL25206
Drosophila virilis
Dvir\GJ13803
Drosophila mojavensis
Dmoj\GI13056
Drosophila grimshawi
Dgri\GH16835
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500FS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015041
Glossina morsitans
Tsetse fly
Gmor\GMOY007894
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04217
Mayetiola destructor
Hessian fly
Mdes\Mdes005606
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL006320
Anopheles darlingi
American malaria mosquito
Adar\ADAC008471
Anopheles gambiae
Malaria mosquito
Agam\AGAP003187
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ013199
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00AK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA004514
Bombyx mori
Silkmoth
Bmor\BGIBMGA004513
Danaus plexippus
Monarch butterfly
Dple\DPOGS216205-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL005843
Apis florea
Little honeybee
Aflo\2152280564
Apis mellifera
Western honey bee
Amel\LOC100577023
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17870
Bombus terrestris
Buff-tailed bumblebee
Bter\15206382
Linepithema humile
Argentine ant
Lhum\LH13553
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001d53
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007248
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_09173
Tribolium castaneum
Red flour beetle
Tcas\TC004289
Pediculus humanus
Human body louse
Phum\PHUM339220
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08287
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00J7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008960
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61182.1
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_14164
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_64323
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G00UH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fn3/Egf/Igf_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ptp69Dl
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (15)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Lar
3 of 10
Ptp36E
3 of 10
Ptp4E
2 of 10
Ptp10D
2 of 10
Ptp52F
2 of 10
PTP-ER
2 of 10
Ptpmeg2
2 of 10
CG42327
1 of 10
csw
1 of 10
IA-2
1 of 10
Pez
1 of 10
Ptp61F
1 of 10
Ptp99A
1 of 10
Ptpmeg
1 of 10
Wsck
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    PTPRC; protein tyrosine phosphatase receptor type C
    6 of 15
    151460
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Ptp69D
    anti tag coimmunoprecipitation, anti tag western blot
    (Garrity et al., 1999)
    Ptp69D - Abl
    enzymatic study, autoradiography
    (Wills et al., 1999)
    Ptp69D - Dscam1
    anti tag coimmunoprecipitation, western blot
    (Dascenco et al., 2015)
    Ptp69D - Hmg-2
    two hybrid
    (Bugga et al., 2009)
    Ptp69D - ena
    pull down, western blot
    (Wills et al., 1999)
    Ptp69D - robo3
    anti tag coimmunoprecipitation, anti tag western blot
    (Oliva et al., 2016)
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Ptp69D
    suppressible
    Lar::Ptp69D
    (Maurel-Zaffran et al., 2001)
    Ptp69D
    suppressible
    Lar
    (Maurel-Zaffran et al., 2001)
    Ptp69D
    enhanceable
    Ptp52F
    (Schindelholz et al., 2001)
    Ptp69D
    enhanceable
    Ptp99A
    (Desai et al., 1996)
    Ptp69D
    suppressible
    Ptp99A
    (Desai and Purdy, 2003)
    Ptp69D|Ptp10D
    enhanceable
    sli
    (Sun et al., 2000)
    Ptp69D
    enhanceable
    sotv
    (Poe et al., 2017)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    comm
    suppressible
    Ptp10D|Ptp69D
    (Sun et al., 2000)
    Lar
    enhanceable
    Ptp69D
    (Poe et al., 2017)
    Ptp52F
    enhanceable
    Ptp69D
    (Schindelholz et al., 2001)
    robo2
    suppressible
    Ptp69D
    (Oliva et al., 2016)
    robo2
    enhanceable
    Ptp69D
    (Oliva et al., 2016)
    robo3
    suppressible
    Ptp69D
    (Oliva et al., 2016)
    sas
    enhanceable
    Ptp69D
    (Lee et al., 2013)
    sotv
    enhanceable
    Ptp69D
    (Poe et al., 2017)
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map

    3-39

    Cytogenetic map
    69D6-69E1
    Sequence location
    3L:12,734,945..12,741,568 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    69D6-69E1
    Limits computationally determined from genome sequence between P{PZ}l(3)0508805088 and P{PZ}l(3)0692406924
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    Experimentally Determined Recombination Data
    Location

    3-39

    (FlyBase, 2016)

    3-33.2

    (Comeron et al., 2012)

    3-

    Left of (cM)
    (Desai and Purdy, 2003)
    Right of (cM)
    (Desai and Purdy, 2003)
    Notes
    Stocks and Reagents
    Stocks (43)
    Genomic Clones (18)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (63)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     

    monoclonal

    (Garrity et al., 1999)
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Additional comments
    Other Comments

    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

    (Kiger et al., 2003)

    Ptp69D is required for correct targeting of R7 axons.

    (Newsome et al., 2000)

    Ptp10D and Ptp69D are necessary for repulsion of growth cones from the midline of the embryonic central nervous system.

    (Sun et al., 2000)

    The phosphatase and FN3 domains of Ptp69D are required for R1-R6 targeting.

    (Garrity et al., 1999)

    Ptp69D is required, though not sufficient for targeting of R1-R6 axons to the lamina.

    (Garrity et al., 1999)

    In Ptp69D mutants R1-R6 project through the lamina, terminating in the medulla.

    (Garrity et al., 1999)

    Requirements of Lar, Ptp69D and Ptp99A in growth cone guidance decisions along the ISN and SNb motor pathways demonstrates relationships among the tyrosine phosphatases are complex and dependent on cellular context. At growth cone choice points along one nerve, two phosphatases cooperate, while along another nerve these same phosphatases can act in opposition to one another. Lar is central to ISN guidance, Ptp69D and Ptp99A are not essential but do participate in guidance processes involving Lar.

    (Desai et al., 1997)

    The products of the Ptp69D and Ptp99A genes are required for motor axon guidance and have partially redundant functions during development of the neuromuscular junction.

    (Desai et al., 1996)

    Ptp69D is a member of a family of receptor linked protein tyrosine phosphatases.

    (Streuli et al., 1989)
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 48 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (20)
    Reported As
    Symbol Synonym
    69D
    (Lee et al., 2013)
    CG10975
    (Christis and Munro, 2012, Khanna et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Schiess et al., 2009, Berger et al., 2008, Morrison et al., 2000)
    CT30751
    (Hynes and Zhao, 2000)
    DPTP
    (Halaby and Mornon, 1998, Chiba and Keshishian, 1996, Sells and Chernoff, 1995, Oon et al., 1993, Tian et al., 1991)
    DPTP69D
    (Quinones et al., 2010, Madan and Gopal, 2008, Raghava et al., 2008, Fox and Zinn, 2005, Ensslen-Craig and Brady-Kalnay, 2004, Muda et al., 2002, Patel and Van Vactor, 2002, Reinhard et al., 2001, Schindelholz et al., 2001, Stoker, 2001, Sun et al., 2001, den Hertog, 1999, Schau et al., 1999, Tear, 1999, Van Etten, 1999, Wills et al., 1999, Chiba and Rose, 1998, Stoker and Dutta, 1998, Van Vactor, 1998, Van Vactor, 1998, Van Vactor et al., 1998, deLapeyriere and Henderson, 1997, Desai et al., 1997, Desai et al., 1997, Desai et al., 1997, Fashena and Zinn, 1997, Garrity et al., 1997, Goodman et al., 1997, Neel and Tonks, 1997, Sun et al., 1997, Chien, 1996, Roush, 1996, Tonks and Neel, 1996, Desai et al., 1995, Fitzpatrick et al., 1995, Desai et al., 1994)
    Dptp69D
    (Bateman and Van Vactor, 2001)
    PTP69D
    (Bali et al., 2019, Lee and Godenschwege, 2015, Cameron et al., 2013, Tong et al., 2011, Song et al., 2008, Bazigou et al., 2007, Hofmeyer et al., 2007, Morey et al., 2005, Andersen et al., 2004, Rao et al., 2002, Chiba, 2001, Newsome et al., 1999)
    PTPase
    (Hynes and Zhao, 2000)
    Ptp
    Ptp69D
    (Hall et al., 2019, Poe et al., 2019, Williamson and Vale, 2018, Hakeda-Suzuki et al., 2017, Poe et al., 2017, Transgenic RNAi Project members, 2017-, Hatzihristidis et al., 2015, Pogson et al., 2014, Sopko et al., 2014, Carter, 2013, Kwon et al., 2013, Lee et al., 2013, Ozkan et al., 2013, Sen et al., 2013, Hadjieconomou et al., 2011, Weng et al., 2011, Wasbrough et al., 2010, Wright et al., 2010, Bugga et al., 2009, Christensen et al., 2009.2.28, Hofmeyer and Treisman, 2009, Tan et al., 2009, Berger et al., 2008, Christensen et al., 2008.4.15, Jeon et al., 2008, Kurusu and Zinn, 2008, Christensen et al., 2007.10.29, Dietzl et al., 2007, Xing et al., 2007, Rehwinkel et al., 2005, Sun et al., 2001)
    Ptp69d
    (Bakal et al., 2008, Tayler and Garrity, 2003)
    R-PTP 69D
    (Morrison et al., 2000)
    RPtp69D
    (Dascenco et al., 2015)
    dptp69D
    (Ackley and Jin, 2004, Landgraf et al., 1999, Netter et al., 1998, Garrity et al., 1997, Desai et al., 1996, Stoker, 1996)
    dptp69d
    (Babu et al., 2005)
    ptp69D
    (Weng et al., 2011, Berger et al., 2008, Grueber et al., 2007, Newsome et al., 1999)
    ptp69d
    (Mattila et al., 2008)
    rptp69d
    (Oliva et al., 2016)
    Name Synonyms
    Protein tyrosine phosphatase 69D
    (Khanna et al., 2010, Xing et al., 2007)
    protein tyrosine phosphatase PTP69D
    (Song et al., 2008)
    Secondary FlyBase IDs
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (177)