DPTP69D, DPTP
receptor tyrosine phosphatase involved in axon guidance - Ptp10D-Ptp69D double mutants have a strong phenotype in which embryonic CNS axons abnormally cross the ventral midline - Ptp69D physically and genetically interacts with Dscam1 to regulate arborization of mechanosensory neurons
Please see the JBrowse view of Dmel\Ptp69D for information on other features
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Gene model reviewed during 5.45
4.477 (longest cDNA)
None of the polypeptides share 100% sequence identity.
1462 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ptp69D using the Feature Mapper tool.
Comment: maternally deposited
GBrowse - Visual display of RNA-Seq signals
View Dmel\Ptp69D in GBrowse 23-39
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Ptp69D is required for correct targeting of R7 axons.
The phosphatase and FN3 domains of Ptp69D are required for R1-R6 targeting.
Ptp69D is required, though not sufficient for targeting of R1-R6 axons to the lamina.
In Ptp69D mutants R1-R6 project through the lamina, terminating in the medulla.
Requirements of Lar, Ptp69D and Ptp99A in growth cone guidance decisions along the ISN and SNb motor pathways demonstrates relationships among the tyrosine phosphatases are complex and dependent on cellular context. At growth cone choice points along one nerve, two phosphatases cooperate, while along another nerve these same phosphatases can act in opposition to one another. Lar is central to ISN guidance, Ptp69D and Ptp99A are not essential but do participate in guidance processes involving Lar.
Ptp69D is a member of a family of receptor linked protein tyrosine phosphatases.