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General Information
Symbol
Dmel\Rel
Species
D. melanogaster
Name
Relish
Annotation Symbol
CG11992
Feature Type
FlyBase ID
FBgn0014018
Gene Model Status
Stock Availability
Gene Snapshot
Relish (Rel) encodes a transcription factor and the downstream component of the immune deficiency pathway, which regulates the antibacterial response and other less characterized cellular processes. [Date last reviewed: 2019-03-14]
Also Known As

NF-κB, ird4, NFκB, l(3)neo36

Key Links
Genomic Location
Cytogenetic map
Sequence location
3R:9,044,183..9,047,977 [-]
Recombination map

3-48

RefSeq locus
NT_033777 REGION:9044183..9047977
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (30 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Biological Process (22 terms)
Terms Based on Experimental Evidence (22 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from expression pattern
inferred from expression pattern
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:brm; FB:FBgn0000212
inferred from genetic interaction with FLYBASE:mor; FB:FBgn0002783
inferred from direct assay
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
NUCLEAR FACTOR - KAPPA B -
The NF-κB transcription factor family share an N-terminal Rel homology domain. NF-κB transcription factors play a major role in development and immunity. (Adapted from FBrf0155649 and FBrf0210750).
NUCLEAR FACTOR - KAPPA B INHIBITOR FAMILY -
The activity of NF-κB transcription factors is regulated by interaction with inhibitory IκB proteins. IκB family members are characterized by multiple ankyrin repeat regions through which they bind Rel homology domain of NF-κB transcription factors. (Adapted from FBrf0233452.)
Pathway (FlyBase)
Imd Signaling Pathway Core Components -
The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
Protein Function (UniProtKB)
Plays a key role in the humoral immune response (PubMed:8816802, PubMed:10619029, PubMed:11269501, PubMed:11872802, PubMed:22022271). Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes (PubMed:11269501). I-kappa-B kinase complex (IKKbeta and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation (PubMed:11872802, PubMed:11018014). Part of a Toll-related receptor pathway that functions in the apoptosis of unfit cells during cell competition (PubMed:25477468). May be part of a NF-kappa-B and Tollo signaling cascade that regulates development of the peripheral nervous system (PubMed:18000549). Possibly post-transcriptionally regulates the neuron-specific genes sc and ase, by promoting the rapid turnover of their transcripts in the wing imaginal disk (PubMed:18000549).
(UniProt, Q94527)
Summary (Interactive Fly)

Ankyrin-repeat and NFkappaB domain protein - a key factor in the induction of the humoral immune response in Drosophila, including antibacterial as well as antifungal factors

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Rel for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0089338
3499
971
FBtr0089339
3351
971
FBtr0089340
3042
971
FBtr0089341
2722
859
Additional Transcript Data and Comments
Reported size (kB)

3.5, 3.4, 3.1, 2.7 (northern blot)

3.4, 3.1, 2.7 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0088375
109.8
971
6.49
FBpp0088973
109.8
971
6.49
FBpp0088971
109.8
971
6.49
FBpp0088972
97.9
859
6.54
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

971 aa isoforms: Rel-PA, Rel-PB, Rel-PC
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

Rel-p68 subunit interacts with Dredd (PubMed:11269502). Interacts with DMAP1 (PubMed:24947515). Interacts with akirin; interaction is immune stimulation-dependent; activates selected rel target gene promoters (PubMed:25180232).

(UniProt, Q94527)
Post Translational Modification

Phosphorylated by lipopolysaccharide (LPS)-activated I-kappa-B kinase complex before being cleaved. Rel-p110 subunit is cleaved within seconds of an immune challenge into Rel-p49 subunit and Rel-p68 subunit. Rel-p110 subunit reappears after 45 minutes.

(UniProt, Q94527)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Rel using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Rel expression in salivary glands begins 8 hours prior to puparium formation, and ends 12 hours after puparium formation, with a peak 2 hours APF.

3.4kb Rel transcripts are expressed constitutively and are induced about 15-fold upon infection.

The 3.1kb Rel transcripts are undetectable in untreated flies and are induced greater than 50-fold in infected flies.

A 2.7kb Rel transcript is present in early embryos and uninjected adult females.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Rel in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 35 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Rel
Transgenic constructs containing regulatory region of Rel
Deletions and Duplications ( 2 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
7 of 15
Yes
Yes
6 of 15
No
Yes
2 of 15
No
No
3121  
2 of 15
No
No
2 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
7 of 15
Yes
Yes
6 of 15
No
Yes
1  
2 of 15
No
No
1  
2 of 15
No
No
2 of 15
No
No
Rattus norvegicus (Norway rat) (5)
6 of 13
Yes
Yes
5 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (5)
4 of 12
Yes
Yes
4 of 12
Yes
Yes
2 of 12
No
No
2 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (5)
8 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190381 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150349 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W03U1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X03RC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
2 of 10
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 2 )
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Rel-p68 subunit interacts with Dredd (PubMed:11269502). Interacts with DMAP1 (PubMed:24947515). Interacts with akirin; interaction is immune stimulation-dependent; activates selected rel target gene promoters (PubMed:25180232).
    (UniProt, Q94527 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Imd Signaling Pathway Core Components -
    The immune deficiency (Imd) pathway primarily mediates the humoral immune response to Gram-negative bacteria. Activation of the Imd pathway by diaminopimelic acid-type peptidoglycan initiates a signaling cascade that ultimately results in the release of the NFκB-like factor Rel from auto-inhibition and its translocation into the nucleus to activate the transcription of antimicrobial peptides. (Adapted from FBrf0224587 and FBrf0238555.)
    Metabolic Pathways
    External Data
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3R
    Recombination map

    3-48

    Cytogenetic map
    Sequence location
    3R:9,044,183..9,047,977 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    85C3-85C3
    Limits computationally determined from genome sequence between P{lacW}l(3)L4740L4740 and P{EP}D1EP473
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    85C9-85C10
    (determined by in situ hybridisation)
    85C1-85C13
    (determined by in situ hybridisation)
    85C-85C
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Notes
    Stocks and Reagents
    Stocks (28)
    Genomic Clones (17)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (77)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of

    Source for merge of: Rel l(3)neo36

    Source for merge of: Rel ird4

    Additional comments
    Other Comments

    Rel is necessary to provide immunity to reactive oxygen species-resistant pathogens.

    RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a specific decrease in AttA activity in response to heat-killed E.coli, and a reduction of Drs response via the Tl pathway, when assayed in S2 cells.

    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

    Rel endoproteolysis appears to be carried out by the caspase Dredd.

    Area matching Drosophila relish gene (inverted), Acc No. U62005.

    Mutants show no detectable induction of Dpt, CecA1 and CecA2. Attacin levels are reduced compared to wild type and Drs induction is normal.

    Identified as a gene with significant level of mRNA cycling as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day. Shows alteration in expression in a Clk mutant background.

    Identification: as a mutation that fails to induce expression of Ecol\lacZDpt.PR normally in response to infection. 4 "ird4" alleles have been obtained.

    The Rel protein is rapidly cleaved into two parts after immune challenge. An N-terminal fragment, containing the DNA-binding Rel homology domain, translocates to the nucleus, while the C-terminal IκB-like fragment remains in the cytoplasm.

    Identification: EMS screen for mutations that prevent Dpt expression in response to infection.

    Mutants exhibit a block of Dif nuclear localisation in response to infection.

    Rel is required for the signal-dependent localisation of Dif and has a less important or indirect role in nuclear localisation of dl.

    Rel encodes a protein containing both a rel homology domain and an IκB-like domain. Rel is strongly induced in infected flies, and a Rel transcript is also detected in early embryos. Rel can activate transcription from the CecA1 promoter of a CecA1-Ecol\lacZ reporter construct.

    Identified in a PCR differential display screen for genes induced when the immune system is activated.

    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 108 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (23)
    Reported As
    Symbol Synonym
    Rel
    (Deng et al., 2020, Hung et al., 2020, Lim et al., 2020, Aalto et al., 2019, Araki et al., 2019, Carty and Bowie, 2019, Chaudhary and Boutros, 2019, Chen et al., 2019, Chowdhury et al., 2019, Engel et al., 2019, Fahey-Lozano et al., 2019, Hanson et al., 2019, Houtz et al., 2019, Khan et al., 2019, Lang et al., 2019, Lin et al., 2019, Maitra et al., 2019, Meltzer et al., 2019, Sanchez Bosch et al., 2019, Shokri et al., 2019, Shukla et al., 2019, Si et al., 2019, Tang and Engström, 2019, Troha and Buchon, 2019, Wang et al., 2019, Westfall et al., 2019, Akishina et al., 2018, Anthoney et al., 2018, Bischof et al., 2018, Davie et al., 2018, Davis and Rebay, 2018, Goto et al., 2018, Harris et al., 2018, Kwon et al., 2018, Li et al., 2018, Shibata and Kawabata, 2018, Steele et al., 2018, Troha et al., 2018, Yu et al., 2018, Akishina et al., 2017, Bastos et al., 2017, Christesen et al., 2017, Daisley et al., 2017, Dostálová et al., 2017, Keesey et al., 2017, Khadilkar et al., 2017, Kim et al., 2017, Kurz et al., 2017, Maki et al., 2017, Park et al., 2017, Romero-Pozuelo et al., 2017, Transgenic RNAi Project members, 2017-, Chatterjee et al., 2016, Di Gregorio et al., 2016, Guillou et al., 2016, Kučerová et al., 2016, Lamiable et al., 2016, Mistry et al., 2016, Baëza et al., 2015, Fan et al., 2015, Jasper, 2015, Kanoh et al., 2015, Li and Dijkers, 2015, Liu et al., 2015, Ma et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Sansone et al., 2015, Schertel et al., 2015, Sudmeier et al., 2015, Vedanayagam and Garrigan, 2015, Verma and Tapadia, 2015, Xia et al., 2015, Xiao et al., 2015, Zhang et al., 2015, Binggeli et al., 2014, Bonnay et al., 2014, Chen et al., 2014, Engel et al., 2014, Goto et al., 2014, Guo et al., 2014, Kuo and Williams, 2014, Kuo and Williams, 2014, Terhzaz et al., 2014, Aparicio et al., 2013, Ayyaz and Jasper, 2013, Buchon et al., 2013, Christofi and Apidianakis, 2013, Clark et al., 2013, Dantoft et al., 2013, Fukuyama et al., 2013, Gendrin et al., 2013, Huang et al., 2013, Iyer et al., 2013, Kari et al., 2013, Katzenberger et al., 2013, Petersen et al., 2013, Sen et al., 2013, Sen et al., 2013, Short and Lazzaro, 2013, Shravage et al., 2013, Spokony and White, 2013.5.10, Stefanatos et al., 2013, Zhang et al., 2013, An et al., 2012, Berger et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Liu et al., 2012, Pilátová and Dionne, 2012, Rincon-Arano et al., 2012, Vanha-Aho et al., 2012, Wu et al., 2012, Clark et al., 2011, Narbonne-Reveau et al., 2011, Paredes et al., 2011, Zaidman-Rémy et al., 2011, Zhang and Arnosti, 2011, Zhao et al., 2011, Becker et al., 2010, Blanco et al., 2010, Buechling et al., 2010, Chen et al., 2010, Hill-Burns and Clark, 2010, Kong et al., 2010, Kuo et al., 2010, Matova and Anderson, 2010, Tanji et al., 2010, Tsuda et al., 2010, Buchon et al., 2009, Buchon et al., 2009, Buchon et al., 2009, Defaye et al., 2009, Dijkers and O'Farrell, 2009, Gendrin et al., 2009, Ha et al., 2009, Ha et al., 2009, Ha et al., 2009, Harbison et al., 2009, Helenius et al., 2009, Jin et al., 2009, Prokupek et al., 2009, Wiklund et al., 2009, Aggarwal et al., 2008, Boltz and Carney, 2008, Choi et al., 2008, Davis et al., 2008, Goto et al., 2008, Jin et al., 2008, Lhocine et al., 2008, Linder et al., 2008, Ratnaparkhi and Courey, 2008, Ratnaparkhi et al., 2008, Vonkavaara et al., 2008, Xi et al., 2008, Yano et al., 2008, Yatsu et al., 2008, Ayyar et al., 2007, Bidla et al., 2007, Copley et al., 2007, Curtis et al., 2007, Dijkers and O'Farrell, 2007, Junell et al., 2007, Kim et al., 2007, Kuranaga and Miura, 2007, Sackton et al., 2007, Valanne et al., 2007, Weiler, 2007, Bergmann, 2006, Brun et al., 2006, Kambris et al., 2006, Kambris et al., 2006, Kim et al., 2006, Libert et al., 2006, Liehl et al., 2006, Matova and Anderson, 2006, Scherfer et al., 2006, Zaidman-Remy et al., 2006, Gesellchen et al., 2005, Kim et al., 2005, Lee et al., 2005, McGettigan et al., 2005, Thoetkiattikul et al., 2005, Yagi and Ip, 2005, Lau et al., 2003, Uvell and Engstrom, 2003, Cornwell and Kirkpatrick, 2001, Gim et al., 2001, Dushay et al., 1996)
    Name Synonyms
    Nuclear Factor-kappa-B p110
    Nuclear factor NF-kappa-B p110 subunit
    Relish
    (Blount et al., 2020, Iwashita et al., 2020, Lee et al., 2020, Ma et al., 2020, Ramond et al., 2020, Zhang et al., 2020, Chen et al., 2019, Chowdhury et al., 2019, Valanne et al., 2019, Wang et al., 2019, Badinloo et al., 2018, Cara et al., 2018, Goto et al., 2018, Hori et al., 2018, Kounatidis and Chtarbanova, 2018, Losada-Perez, 2018, Ly et al., 2018, Min and Tatar, 2018, Palmer et al., 2018, Shahrestani et al., 2018, Sherri et al., 2018, Su et al., 2018, Westfall et al., 2018, Yuan et al., 2018, Zhai et al., 2018, Allada et al., 2017, Keita et al., 2017, Kenmoku et al., 2017, Kounatidis et al., 2017, Kurz et al., 2017, Liu et al., 2017, Maki et al., 2017, Mussabekova et al., 2017, Tavignot et al., 2017, Yadav et al., 2017, Ji et al., 2016, Kaynar et al., 2016, Kumar et al., 2016, Lim and Tsuda, 2016, Troutwine et al., 2016, Yadav and Tapadia, 2016, Yadav et al., 2016, Bandarra et al., 2015, Castillo et al., 2015, Kanoh et al., 2015, Li and Dijkers, 2015, Liu et al., 2015, Liu et al., 2015, Momiuchi et al., 2015, Shirinian et al., 2015, Stratoulias and Heino, 2015, Terhzaz et al., 2015, Vedanayagam and Garrigan, 2015, Yu et al., 2015, Bonnay et al., 2014, Goto et al., 2014, Imler, 2014, Keebaugh and Schlenke, 2014, Kim et al., 2014, Kleino and Silverman, 2014, Lee and Lee, 2014, Lindsay and Wasserman, 2014, Myllymäki et al., 2014, Panayidou et al., 2014, Tan et al., 2014, Terhzaz et al., 2014, Verma and Tapadia, 2014, Xu and Cherry, 2014, Aparicio et al., 2013, Cao et al., 2013, Clark et al., 2013, Dantoft et al., 2013, Ferrandon, 2013, Fukuyama et al., 2013, Kemp et al., 2013, Kingsolver et al., 2013, Luo et al., 2013, Owusu-Ansah et al., 2013, Shravage et al., 2013, Wang et al., 2013, An et al., 2012, Bitra et al., 2012, Bosco-Drayon et al., 2012, Felix et al., 2012, Jones et al., 2012, Meinander et al., 2012, Overend et al., 2012, Tsuzuki et al., 2012, Vandenabeele and Bertrand, 2012, Vanha-Aho et al., 2012, Verma and Tapadia, 2012, Wang et al., 2012, Akhouayri et al., 2011, Fullaondo et al., 2011, Garcia and Stathopoulos, 2011, Karpac et al., 2011, Marcu et al., 2011, Narbonne-Reveau et al., 2011, Ragab et al., 2011, Sehgal and Mignot, 2011, van Uden et al., 2011, Zaidman-Rémy et al., 2011, Becker et al., 2010, Kallio et al., 2010, Kuo et al., 2010, O'Callaghan and Vergunst, 2010, Radyuk et al., 2010, Ryu et al., 2010, Sabin et al., 2010, Tanji et al., 2010, Valanne et al., 2010, Berkey et al., 2009, Buchon et al., 2009, Defaye et al., 2009, Diangelo et al., 2009, Dijkers and O'Farrell, 2009, Ertürk-Hasdemir et al., 2009, Gendrin et al., 2009, Geuking et al., 2009, Ha et al., 2009, Harbison et al., 2009, Helenius et al., 2009, Jin et al., 2009, Liu et al., 2009, Obbard et al., 2009, Towb et al., 2009, Wiklund et al., 2009, Aggarwal et al., 2008, Choi et al., 2008, Davis et al., 2008, Goto et al., 2008, Hernandez-Romano et al., 2008, Jin et al., 2008, Jones et al., 2008, Kleino et al., 2008, Krupinski et al., 2008, Lhocine et al., 2008, Maillet et al., 2008, Orr et al., 2008, Pal et al., 2008, Ratnaparkhi and Courey, 2008, Ratnaparkhi et al., 2008, Reed et al., 2008, Ryu et al., 2008, Sekiya et al., 2008, Silverman et al., 2008, Tsai et al., 2008, Vonkavaara et al., 2008, Xi et al., 2008, Yano et al., 2008, Ayyar et al., 2007, Busse et al., 2007, Copley et al., 2007, Dijkers and O'Farrell, 2007, Huh et al., 2007, Kim et al., 2007, Levine and Begun, 2007, Libert et al., 2007, Minidorff et al., 2007, Sackton et al., 2007, Valanne et al., 2007, Waterhouse et al., 2007, Williams et al., 2007, Wu and Silverman, 2007, Wu et al., 2007, Akira et al., 2006, Brun et al., 2006, Delaney et al., 2006, Kim et al., 2006, Kim et al., 2006, Leulier et al., 2006, Libert et al., 2006, Liehl et al., 2006, Matova and Anderson, 2006, Minakhina and Steward, 2006, Ryu et al., 2006, Saleh et al., 2006, Scherfer et al., 2006, Senger et al., 2006, Gesellchen et al., 2005, Greene et al., 2005, Kim et al., 2005, Lee et al., 2005, Wertheim et al., 2005, Yagi and Ip, 2005, Bettencourt et al., 2004, Roxstrom-Lindquist et al., 2004, Ryu et al., 2004, Cha et al., 2003, Minakhina et al., 2003, Park et al., 2003, Uvell and Engstrom, 2003, Yajima et al., 2003, Avila et al., 2002, Bhattacharya and Steward, 2002, Lehmann et al., 2002, Roxstrom-Lindquist et al., 2002, Gim et al., 2001, Lindmark et al., 2001, Silverman et al., 2000, Asling, 1999.9.13, Hedengren, 1999.9.14, Hedengren, 1999.9.14, Hedengren, 1999.9.14, Hedengren, 1999.9.14, Hedengren, 1999.9.14, Hedengren, 1999.9.14, Dushay et al., 1997, Dushay, 1996.6.24, Dushay et al., 1996, Hultmark, 1995.6.7)
    immune response deficient 4
    Secondary FlyBase IDs
    • FBgn0011469
    • FBgn0024223
    Datasets (0)
    Study focus (0)
    Experimental Role
    Project
    Project Type
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    References (652)