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Gene Dmel\Rh5

General Information
Symbol	Dmel\Rh5	Species	D. melanogaster
Name	Rhodopsin 5	Annotation symbol	CG5279
Feature type	protein_coding_gene	FlyBase ID	FBgn0014019
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	33B8-33B8	Sequence location	2L:12,008,153..12,009,832 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Rhodopsin 5 is referred to in FlyBase by the symbol Dmel\Rh5 (CG5279, FBgn0014019). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: G-protein coupled photoreceptor activity. There is experimental evidence that it is involved in the biological process: phototransduction; response to light stimulus; sensory perception of sound; absorption of visible light. 19 alleles are reported. The phenotype of these alleles is annotated with: eye photoreceptor cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: G protein-coupled receptor, rhodopsin-like; GPCR, rhodopsin-like, 7TM; Opsin; Opsin RH3/RH4. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Comments on Affy2 ProbeSet: ProbeSet 1628806_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Rh5. Gene sequence location is 2L:12008376..12009846.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03	Polypeptides Rh5-PB Transcripts Rh5-RB
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 33B8-33B8   Limits computationally determined from genome sequence between P{EP}MESK1EP980 and P{PZ}l(2)0181001810&P{EP}CG6785EP340
Experimentally Determined Cytological Location
Cytogenetic map Notes References 33B1-33B14     (Desplan, 1996.12.2) 33B5-33B6     (Chou, 1996.8.23) 33B-33B   (determined by in situ hybridisation)   (Papatsenko et al., 1997) 33B5-33B6   (determined by in situ hybridisation)   (Chou et al., 1996)
Experimentally Determined Recombination Data
Location	2- (Desplan, 1996.12.2, )
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rh5 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rh5-RA FBtr0080291  NM_057748   1347   382 Rh5-RB FBtr0342591     1572   382
Additional Transcript Data & Comments
Reported size (kB)	1.4 (northern blot) (Chou et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rh5-PA   FBpp0079875   42.7   382   7.83     NP_477096   AAF53145 Rh5-PB   FBpp0309539   42.7   382   7.83
Additional Polypeptide Data & Comments
Reported size (kDa)	382 (aa); 43 (kD predicted) (Papatsenko et al., 1997) 382 (aa) (Chou et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • G protein-coupled receptor, rhodopsin-like (IPR000276) Opsin RH3/RH4 (IPR000856) GPCR, rhodopsin-like, 7TM (IPR017452) Visual pigments (opsins) retinal binding site (IPR027430)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53145   AC011065   AI238259   AI292486   AI387119   AI388501   AI389730   AI405843   AI513954   AI513992   AI517572   AW941099   AY069237 AAL39382   BI565847   BI565866   BI585314   BI585321   BI585327   BI589491   BI589501   BI593684   BI607765   BI611993   BI616048   BI624107   BI628115   CA805835   CO287736   CO290061   CO327971   CO330969   EC051828   EC051833   EC054760   EC196112   EC242198   EC250858   EC259915   EL869626   U67905 AAC47426   U80667 AAB38966   U80856
UniProtKB/Swiss-Prot	P91657
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000161194 2L:12,008,327..12,008,337 comment=P3/RCS-1 site; putative ey protein binding site. evidence=predicted (Papatsenko et al., 1997) regulatory region FBsf0000436548 2L:12,007,710..12,008,448 evidence=Reporter construct (in vivo) (Papatsenko et al., 2001, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage   eye   (Xu et al., 2004) in situ Stage Tissue/Position (including subcellular localization) Reference adult stage   photoreceptor cell R8   (Papatsenko et al., 1997) northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Chou et al., 1996)
Additional Descriptive Data
	Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads. (Xu et al., 2004) Rh5 is expressed in a subset of R8 photoreceptor cells. It is specifically expressed in R8 cells underlying Rh3-expressing R7 cells but never under Rh4-expressing R7 cells. (Papatsenko et al., 1997) Rh5 transcripts are detected in RNA from adult heads but not bodies on northern blots. (Chou et al., 1996)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference larval stage   Bolwig organ   (Rosenbaum et al., 2011) adult stage   photoreceptor cell R8   (Chou et al., 1996)
Additional Descriptive Data
	Rh5 expression is limited to a subset of the R8 photoreceptor cells. It was known previously that Rh3 is expressed in a subset of R7 photoreceptors cells. It was found here that there is a precise pairing of Rh3 and Rh5 expression within the R7 and R8 cells of individual ommatidia. (Chou et al., 1996)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
rhabdomere inferred from direct assay (Salcedo et al., 1999)
Expression Deduced from Reporters
Reporter: P{Rh5-lacZ.-560} Stage Tissue/Position (including subcellular localization) Reference larval stage   Rh5 photoreceptor of Bolwig organ   (Keene et al., 2011) adult stage   photoreceptor cell R8 | subset   (Papatsenko et al., 2001)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    12.325 Larval Midgut    24.7 Larval Hindgut    11.7 Larval Malpighian Tubules    12.5 Larval Fat Body    18.4 Larval Salivary Gland    15.5 Larval Trachea    104.25 Larval Carcass    17.175 Adult Head    1530.5 Adult Eye    5777.575 Adult Brain    19.7 Adult Thoracic-Abdominal Ganglion    15 Adult Crop    11.8 Adult Midgut    20.4 Adult Hindgut    16.1 Adult Malpighian Tubules    12.9 Adult Fat Body    17.3 Adult Salivary Gland    10.4 Adult Heart    14.625 Adult VirginFemale Spermatheca    13.8 Adult InseminatedFemale Spermatheca    14.6 Adult Ovary    8.8 Adult Testis    13.4 Adult Male Accessory Gland    3.5 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    12.325 Larval Midgut    24.7 Larval Hindgut    11.7 Larval Malpighian Tubules    12.5 Larval Fat Body    18.4 Larval Salivary Gland    15.5 Larval Trachea    104.25 Larval Carcass    17.175 Adult Head  (1530.5) Adult Eye  (5777.575) Adult Brain    19.7 Adult Thoracic-Abdominal Ganglion    15 Adult Crop    11.8 Adult Midgut    20.4 Adult Hindgut    16.1 Adult Malpighian Tubules    12.9 Adult Fat Body    17.3 Adult Salivary Gland    10.4 Adult Heart    14.625 Adult VirginFemale Spermatheca    13.8 Adult InseminatedFemale Spermatheca    14.6 Adult Ovary    8.8 Adult Testis    13.4 Adult Male Accessory Gland    3.5 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    12.325 Larval Midgut    24.7 Larval Hindgut    11.7 Larval Malpighian Tubules    12.5 Larval Fat Body    18.4 Larval Salivary Gland    15.5 Larval Trachea    104.25 Larval Carcass    17.175 Adult Head  (1530.5) Adult Eye  (5777.575) Adult Brain    19.7 Adult Thoracic-Abdominal Ganglion    15 Adult Crop    11.8 Adult Midgut    20.4 Adult Hindgut    16.1 Adult Malpighian Tubules    12.9 Adult Fat Body    17.3 Adult Salivary Gland    10.4 Adult Heart    14.625 Adult VirginFemale Spermatheca    13.8 Adult InseminatedFemale Spermatheca    14.6 Adult Ovary    8.8 Adult Testis    13.4 Adult Male Accessory Gland    3.5 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    12.325 Larval Midgut    24.7 Larval Hindgut    11.7 Larval Malpighian Tubules    12.5 Larval Fat Body    18.4 Larval Salivary Gland    15.5 Larval Trachea    104.25 Larval Carcass    17.175 Adult Head    1530.5 Adult Eye    5777.575 Adult Brain    19.7 Adult Thoracic-Abdominal Ganglion    15 Adult Crop    11.8 Adult Midgut    20.4 Adult Hindgut    16.1 Adult Malpighian Tubules    12.9 Adult Fat Body    17.3 Adult Salivary Gland    10.4 Adult Heart    14.625 Adult VirginFemale Spermatheca    13.8 Adult InseminatedFemale Spermatheca    14.6 Adult Ovary    8.8 Adult Testis    13.4 Adult Male Accessory Gland    3.5 Adult Carcass    17.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    12.325 Larval Midgut    24.7 Larval Hindgut    11.7 Larval Malpighian Tubules    12.5 Larval Fat Body    18.4 Larval Salivary Gland    15.5 Larval Trachea    104.25 Larval Carcass    17.175 Adult Head    1530.5 Adult Eye    5777.575 Adult Brain    19.7 Adult Thoracic-Abdominal Ganglion    15 Adult Crop    11.8 Adult Midgut    20.4 Adult Hindgut    16.1 Adult Malpighian Tubules    12.9 Adult Fat Body    17.3 Adult Salivary Gland    10.4 Adult Heart    14.625 Adult VirginFemale Spermatheca    13.8 Adult InseminatedFemale Spermatheca    14.6 Adult Ovary    8.8 Adult Testis    13.4 Adult Male Accessory Gland    3.5 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    12.325 Larval Midgut    24.7 Larval Hindgut    11.7 Larval Malpighian Tubules    12.5 Larval Fat Body    18.4 Larval Salivary Gland    15.5 Larval Trachea    104.25 Larval Carcass    17.175 Adult Head  (1530.5) Adult Eye  (5777.575) Adult Brain    19.7 Adult Thoracic-Abdominal Ganglion    15 Adult Crop    11.8 Adult Midgut    20.4 Adult Hindgut    16.1 Adult Malpighian Tubules    12.9 Adult Fat Body    17.3 Adult Salivary Gland    10.4 Adult Heart    14.625 Adult VirginFemale Spermatheca    13.8 Adult InseminatedFemale Spermatheca    14.6 Adult Ovary    8.8 Adult Testis    13.4 Adult Male Accessory Gland    3.5 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    12.325 Larval Midgut    24.7 Larval Hindgut    11.7 Larval Malpighian Tubules    12.5 Larval Fat Body    18.4 Larval Salivary Gland    15.5 Larval Trachea    104.25 Larval Carcass    17.175 Adult Head  1530.5 Adult Eye  (5777.575) Adult Brain    19.7 Adult Thoracic-Abdominal Ganglion    15 Adult Crop    11.8 Adult Midgut    20.4 Adult Hindgut    16.1 Adult Malpighian Tubules    12.9 Adult Fat Body    17.3 Adult Salivary Gland    10.4 Adult Heart    14.625 Adult VirginFemale Spermatheca    13.8 Adult InseminatedFemale Spermatheca    14.6 Adult Ovary    8.8 Adult Testis    13.4 Adult Male Accessory Gland    3.5 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    12.325 Larval Midgut    24.7 Larval Hindgut    11.7 Larval Malpighian Tubules    12.5 Larval Fat Body    18.4 Larval Salivary Gland    15.5 Larval Trachea    104.25 Larval Carcass    17.175 Adult Head    1530.5 Adult Eye    5777.575 Adult Brain    19.7 Adult Thoracic-Abdominal Ganglion    15 Adult Crop    11.8 Adult Midgut    20.4 Adult Hindgut    16.1 Adult Malpighian Tubules    12.9 Adult Fat Body    17.3 Adult Salivary Gland    10.4 Adult Heart    14.625 Adult VirginFemale Spermatheca    13.8 Adult InseminatedFemale Spermatheca    14.6 Adult Ovary    8.8 Adult Testis    13.4 Adult Male Accessory Gland    3.5 Adult Carcass    17.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1530.5   NA  Eye    5777.575   NA  Brain    no informative data   no informative data  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    no informative data   no informative data  Midgut    no informative data   no informative data  Hindgut    no informative data   no informative data  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    no informative data   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    no informative data   NA  Ovary    8.8   NA  Testis    no informative data   NA  Male Accessory Gland    3.5   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    55 head, virgin 4-day female    67 head, virgin 20-day female    102 head, mated 1-day female    57 head, mated 4-day female    77 head, mated 20-day female    62 head, mated 1-day male    91 head, mated 4-day male    110 head, mated 20-day male    119 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    7 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female  (55) head, virgin 4-day female  (67) head, virgin 20-day female  (102) head, mated 1-day female  (57) head, mated 4-day female  (77) head, mated 20-day female  (62) head, mated 1-day male  (91) head, mated 4-day male  (110) head, mated 20-day male  (119) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    7 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    55 head, virgin 4-day female    67 head, virgin 20-day female  102 head, mated 1-day female    57 head, mated 4-day female    77 head, mated 20-day female    62 head, mated 1-day male    91 head, mated 4-day male  (110) head, mated 20-day male  (119) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    7 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    55 head, virgin 4-day female    67 head, virgin 20-day female    102 head, mated 1-day female    57 head, mated 4-day female    77 head, mated 20-day female    62 head, mated 1-day male    91 head, mated 4-day male    110 head, mated 20-day male    119 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    7 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    55 head, virgin 4-day female    67 head, virgin 20-day female    102 head, mated 1-day female    57 head, mated 4-day female    77 head, mated 20-day female    62 head, mated 1-day male    91 head, mated 4-day male    110 head, mated 20-day male    119 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    7 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female  (55) head, virgin 4-day female  (67) head, virgin 20-day female  (102) head, mated 1-day female  (57) head, mated 4-day female  (77) head, mated 20-day female  (62) head, mated 1-day male  (91) head, mated 4-day male  (110) head, mated 20-day male  (119) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    7 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    55 head, virgin 4-day female    67 head, virgin 20-day female  102 head, mated 1-day female    57 head, mated 4-day female    77 head, mated 20-day female    62 head, mated 1-day male    91 head, mated 4-day male  110 head, mated 20-day male  119 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    7 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    55 head, virgin 4-day female    67 head, virgin 20-day female    102 head, mated 1-day female    57 head, mated 4-day female    77 head, mated 20-day female    62 head, mated 1-day male    91 head, mated 4-day male    110 head, mated 20-day male    119 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    0 carcass, larvae L3 wandering    1 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    7 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    8 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    11 pupae 4d postWPP    21 adult male 01day    31 adult male 05day    41 adult male 30day    57 adult female 01day    20 adult female 05day    9 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    8 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    11 pupae 4d postWPP    21 adult male 01day  (31) adult male 05day  (41) adult male 30day  (57) adult female 01day    20 adult female 05day    9 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    8 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    11 pupae 4d postWPP    21 adult male 01day    31 adult male 05day    41 adult male 30day    57 adult female 01day    20 adult female 05day    9 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    8 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    11 pupae 4d postWPP    21 adult male 01day    31 adult male 05day    41 adult male 30day    57 adult female 01day    20 adult female 05day    9 adult female 30day    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    8 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    11 pupae 4d postWPP    21 adult male 01day    31 adult male 05day    41 adult male 30day    57 adult female 01day    20 adult female 05day    9 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    8 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    11 pupae 4d postWPP    21 adult male 01day  31 adult male 05day  (41) adult male 30day  (57) adult female 01day    20 adult female 05day    9 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    8 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    11 pupae 4d postWPP    21 adult male 01day    31 adult male 05day    41 adult male 30day    57 adult female 01day    20 adult female 05day    9 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    0 embryo 12-14hr    0 embryo 14-16hr    0 embryo 16-18hr    1 embryo 18-20hr    4 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    8 larva L2    3 larva L3 12hr old    1 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    2 white prepupae 24hr    1 pupae 2d postWPP    1 pupae 3d postWPP    11 pupae 4d postWPP    21 adult male 01day    31 adult male 05day    41 adult male 30day    57 adult female 01day    20 adult female 05day    9 adult female 30day    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    1 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    3 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    2 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    2 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    8 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    6 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    10 Paraquat 10 mM 48 hrs, 4-day adult    14 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_15 mE1_20_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014019 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5279-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Other Phenotypes Allele auditory perception defective | adult stage Rh52 neurophysiology defective | adult stage Rh52 phototaxis defective Rh52 visual behavior defective Rh5N104K.ninaE Phenotype manifest in Allele eye photoreceptor cell Rh5N104K.ninaE
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Rh5 Class Mutagen Stocks Known lesion Rh55-SZ-3619 1 Yes Rh52 FLPase 0 Yes Rh53 P-element activity 0 Yes Rh54 P-element activity 0 Yes Rh55 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rh5 Class Mutagen Stocks Known lesion Rh5KK110268 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rh5A53Y.ninaE in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes Rh5D125Q.Y127F.ninaE in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes Rh5F147Y.ninaE in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes Rh5GD593 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Rh5H38P.R42L.ninaE in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes Rh5I110Y.ninaE in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes Rh5N104K.ninaE in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes Rh5ninaE.PC in vitro construct - regulatory fusion 0 Yes Rh5R243F.ninaE in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes Rh5S325A.ninaE in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes Rh5Scer.UAS.cVa in vitro construct - regulatory fusion 0 Yes Rh5Scer\UAS.T:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes Rh5T173I.W176Y.ninaE in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6031 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD593} NA P{KK110268} NA P{UAS-Rh5-EGFP} NA reporter construct P{Rh3-lacZ.Rh5.RCSI} No P{Rh5-lacZ.-560} No P{Rh5-lacZ.KI.KII} No P{Rh5-lacZ.KI} No P{Rh5-lacZ.KII} No P{Rh5-tau-lacZ} No characterization construct P{ninaE-Rh5.A53Y} NA P{ninaE-Rh5.D125Q.Y127F} NA P{ninaE-Rh5.F147Y} NA P{ninaE-Rh5.H38P.R42L} NA P{ninaE-Rh5.I110Y} NA P{ninaE-Rh5.N104K} NA P{ninaE-Rh5.R243F} NA P{ninaE-Rh5.S325A} NA P{ninaE-Rh5.T173I.W176Y} NA P{Rh1+5} NA P{Rh5-GAL4} NA P{Rh5-lexA} NA P{UAS-Rh5.V} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{GT1}BG01539 NA P{RS5}5-SZ-3619 NA P{SUPor-P}KG08058 NA insertion of mobile activating element P{EP}EP574 NA P{EP}EP2309 NA
Gene Ontology: Function, Process & Cellular Component ( 10 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
G-protein coupled photoreceptor activity inferred from genetic interaction with ninaE (Britt, 1995.4.13, Salcedo et al., 1999)
Biological Process
CV term Evidence References
absorption of visible light inferred from mutant phenotype (Salcedo et al., 2003) phototransduction inferred from genetic interaction with ninaE (Salcedo et al., 1999) inferred from genetic interaction with ninaE AND inferred from sequence or structural similarity with Rh3 AND inferred from sequence or structural similarity with Rh4 AND inferred from sequence or structural similarity with ninaE (Chou et al., 1996) response to light stimulus inferred from direct assay (Keene et al., 2011) sensory perception of sound inferred from mutant phenotype (Senthilan et al., 2012)
Cellular Component
CV term Evidence References
rhabdomere inferred from direct assay (Salcedo et al., 1999)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
G-protein coupled photoreceptor activity inferred from sequence or structural similarity (Brody and Cravchik, 2000) inferred from sequence or structural similarity with EMBL:X80072 AND inferred from sequence or structural similarity with Rh3 AND inferred from sequence or structural similarity with Rh4 (Papatsenko et al., 1997) inferred from sequence or structural similarity with Rh3 AND inferred from sequence or structural similarity with Rh4 AND inferred from sequence or structural similarity with ninaE (Chou et al., 1996) non-traceable author statement (Pichaud et al., 1999, Swiss-Prot Project Members, 1998.2.1)
Biological Process
CV term Evidence References
G-protein coupled receptor signaling pathway inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR000856, InterPro:IPR001760 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Brody and Cravchik, 2000) phototransduction inferred from sequence or structural similarity with EMBL:X80072 AND inferred from sequence or structural similarity with Rh3 AND inferred from sequence or structural similarity with Rh4 (Papatsenko et al., 1997) non-traceable author statement (Montell, 1999) UV-A, blue light phototransduction non-traceable author statement (Pichaud et al., 1999) visual perception inferred from electronic annotation with InterPro:IPR000856, InterPro:IPR001760 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity (Brody and Cravchik, 2000) inferred from sequence or structural similarity with EMBL:X80072 AND inferred from sequence or structural similarity with Rh3 AND inferred from sequence or structural similarity with Rh4 (Papatsenko et al., 1997) inferred from sequence or structural similarity with Rh3 AND inferred from sequence or structural similarity with Rh4 AND inferred from sequence or structural similarity with ninaE (Chou et al., 1996) non-traceable author statement (Swiss-Prot Project Members, 1998.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Rh5 - CG10641 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Rh5 - CG2065 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rh5 - Df31 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rh5 - Myo61F experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Rh5 - Nacα experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Rh5 - Rpn11 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rh5 allele Gene References Rh5ninaE.PC ninaE (Chou et al., 1996, Salcedo et al., 1999)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60667 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0014019 DroID - A comprehensive database of gene and protein interactions. • FBgn0014019 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34615
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6JWW0F Dipteran inclusive ortholog search EOG6DR9MZ Insect inclusive ortholog search EOG6J3VCK Arthropod inclusive ortholog search EOG61JWTR Metazoa inclusive ortholog search EOG6JHR8B
Orthologs in Drosophila Species (EOG6JWW0F)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Rh5     Drosophila simulans   Dsim\GD23807 Y   Drosophila erecta   Dere\GG23755 Y   Drosophila yakuba   Dyak\GE18562 Y   Drosophila ananassae   Dana\GF14411 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA18781 Y   Drosophila persimilis   Dper\GL16118 Y   Drosophila willistoni   Dwil\GK23748 Y   Drosophila virilis   Dvir\GJ17505 Y   Drosophila mojavensis   Dmoj\GI14181 Y   Drosophila grimshawi   Dgri\GH13098 Y
Orthologs in non-Drosophila Dipterans (EOG6DR9MZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003035   Anopheles gambiae Malaria mosquito  Agam\GPROP9   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ013408   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ005000
Orthologs in non-Dipteran Insects (EOG6J3VCK)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\BLOP Y Apis mellifera Western honey bee  Amel\UVOP Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000990 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004208 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19964 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14675 Y Atta cephalotes Leafcutter ant  Acep\ACEP24081 Y Atta cephalotes Leafcutter ant  Acep\ACEP24672 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18506 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO14976 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17713 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22349 Y Linepithema humile Argentine ant  Lhum\LH20507 Y Linepithema humile Argentine ant  Lhum\LH19353 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB27190 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB20309 Y Solenopsis invicta Red fire ant  Sinv\SINV24180 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002544 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004442 Y Bombyx mori Silkmoth  Bmor\BGIBMGA012104 Y Bombyx mori Silkmoth  Bmor\BGIBMGA011685 Y Pediculus humanus Human body louse  Phum\PHUM009850 Y Tribolium castaneum Red flour beetle  Tcas\TC000118 Y
Orthologs in non-Insect Arthropods (EOG61JWTR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\BLOP Y Daphnia pulex Water flea  Dpux\UVOP Y
Orthologs in non-Arthropod Metazoa (EOG6JHR8B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C06G4.5 Y
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23807 Drosophila erecta Dere\GG23755 Drosophila yakuba Dyak\GE18562 Drosophila ananassae Dana\GF14411 Drosophila pseudoobscura pseudoobscura Dpse\GA18781 Drosophila persimilis Dper\GL16118 Drosophila willistoni Dwil\GK23748 Drosophila virilis Dvir\GJ17505 Drosophila mojavensis Dmoj\GI14181 Drosophila grimshawi Dgri\GH13098
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Kyoto	126162 w1118; P{RS5}5-SZ-3619
VDRC	v101930 P{KK110268}VIE-260B
Genomic Clones ( 2 )
	BACR02B06 BACR37P12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 36 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH28578
Other clones	DPiM_GH28578
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH14273 GH15406 GH17559 GH19438 GH20971 GH25984 GH26982 GH27031 RH10638 RH14196 RH18519 RH18962 RH19657 RH27155 RH28269 RH42904 RH54126 RH61755 RH62802 RH69079 RH73913
Other clones	193437 CK01.83C.H3 CK01.93C.F8 EC051828 EC051833 EC054760 EC259915 EK066630 EK072956 EK296737 EP08343 ESG0120a.B21.1_A10 IP01712
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0014019 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34615
Antibody Information
	polyclonal (Chou et al., 1996)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Rh5 CG5279 (Zhong, 1999.11)
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene used in a cell-based RNAi assay to identify components or modifiers of the JAK/STAT pathway. (Mukherjee et al., 2006) Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. (Claridge-Chang et al., 2001) Rh5, a rhodopsin expressed in a subset of R8 photoreceptor cells, has been cloned and characterised. (Papatsenko et al., 1997) Rh5 encodes a functional opsin (restores the light response in ninaE mutants) that is expressed in a subset of R8 photoreceptor cells. (Chou et al., 1996) The Rh5 gene encodes a functional opsin, as demonstrated by electroretinogram analysis of ninaE mutant flies transformed with the Rh5 cDNA, under the control of the ninaE promoter. (Britt, 1995.4.13)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057748 RefSeq (Proteins) • NP_477096 DDBJ / EMBL / GenBank • AAB38966 AAC47426 AAF53145 AAL39382 AC011065 AI517572 AW941099 AY069237 U67905 U80667 U80856 Entrez Gene - A searchable database of RefSeq genes. • 34615 UniProtKB/Swiss-Prot • P91657
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • G protein-coupled receptor, rhodopsin-like (IPR000276) Opsin RH3/RH4 (IPR000856) GPCR, rhodopsin-like, 7TM (IPR017452) Visual pigments (opsins) retinal binding site (IPR027430)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60667 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0014019 DroID - A comprehensive database of gene and protein interactions. • FBgn0014019 DRSC - Results from RNAi screens. • FBgn0014019 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014019 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5279-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0014019 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34615 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34615 modMine - Data generated by the modENCODE project. • FBgn0014019
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	CG5279 (Keleman et al., 2009.8.5) DMELRH5 (Papatsenko et al., 2001) Dm Rh5 (Townson et al., 1998) Rh (Fanning and Anderson, 1999) rh5 (Tahayato et al., 2003, Pistillo and Desplan, 2005, Mikeladze-Dvali et al., 2005, Celik and Desplan, 2003, Cook et al., 2003, Pistillo et al., 2004, Celik and Desplan, 2004, Cook, 2003, Wernet et al., 2002, Wernet et al., 2002, Desplan et al., 2002, Mazzoni et al., 2002, Pichaud et al., 2002, Sonneville et al., 2000, Beaufils et al., 1998, Beaufils et al., 1997, Papatsenko et al., 1997, Jukam et al., 2006, Mikeladze-Dvali et al., 2005, Edgar, 2006, Mazzoni et al., 2005, Vasiliauskas et al., 2008, Jukam and Claude, 2008, Keene et al., 2011, Vasiliauskas et al., 2011, Yamaguchi et al., 2008, Mazzoni et al., 2008, Sprecher and Desplan, 2008, Yamaguchi et al., 2010, Shen et al., 2011, Yuan et al., 2011, Posnien et al., 2012) RH5 (Malpel et al., 2001) Rh5 (Yang et al., 2005, Pistillo and Desplan, 2007, Vasiliauskas et al., 2007, Mikeladze-Dvali et al., 2005, Earl and Britt, 2006, Jukam and Desplan, 2007, Mukherjee et al., 2006, Vasiliauskas et al., 2007, Pistillo et al., 2007, Friedrich, 2006, Hassan et al., 2005, Sprecher et al., 2007, Nelson et al., 2005, Luo et al., 2011, Hummel and Klaembt, 2006, Hsiao et al., 2008, Sprecher and Desplan, 2008, Landry et al., 2007, Sprecher et al., 2011, Bao and Friedrich, 2009, Yuan et al., 2011, Johnston et al., 2011, Rosenbaum et al., 2006, Xie et al., 2007, Miller et al., 2008, Ranade et al., 2008, Edwards and Meinertzhagen, 2009, Birkholz et al., 2009, Wernet et al., 2006, Hanai and Ishida, 2009, Birkholz et al., 2009, Mishra et al., 2010, McDonald et al., 2010, Xiang et al., 2010, Rosenbaum et al., 2011, Terrell et al., 2012, Senthilan et al., 2012)
Name Synonym	rhodopsin (Wernet and Desplan, 2004, Harteneck, 2003, Suel et al., 2002, Dan et al., 2001, Suel and Ranganathan, 1999, Xu et al., 1998) Rhodopsin (Voets and Nilius, 2003, Montell, 2000, Satoh et al., 2002, Hardie and Raghu, 2001) Rhodopsin5 (Greenberg et al., 2005, Keene et al., 2011) Rhodopsin 5 (Britt, 1995.4.13, Earl and Britt, 2006, Bateman and McNeill, 2005, Sprecher et al., 2011) rhodopsin 5 (McDonald et al., 2006, Vasiliauskas et al., 2011, Dalton et al., 2010, Yuan et al., 2011) rhodopsin-5 (Mazzoni et al., 2005)
Secondary FlyBase IDs
References ( 158 )
Generate a list of	All references relating to this gene ( 158 )
List References by type	Research paper  ( 67 ) Supplementary material  ( 4 ) Review  ( 20 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 51 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 )
Recent research papers ( 16 )
	Hsiao et al., 2012, J. Vis. Exp.: Dissection and immunohistochemistry of larval, pupal and adult Drosophila retinas. [FBrf0220029] Posnien et al., 2012, PLoS ONE 7(5): e37346 Evolution of Eye Morphology and Rhodopsin Expression in the Drosophila melanogaster Species Subgroup. [FBrf0218497] Senthilan et al., 2012, Cell 150(5): 1042--1054 Drosophila auditory organ genes and genetic hearing defects. [FBrf0219321] Szular et al., 2012, J. Biol. Rhythms 27(1): 25--36 Rhodopsin 5- and Rhodopsin 6-Mediated Clock Synchronization in Drosophila melanogaster Is Independent of Retinal Phospholipase C-β Signaling. [FBrf0217408] Terrell et al., 2012, Dev. Dyn. 241(1): 215--228 OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. [FBrf0216943] Wardill et al., 2012, Science 336(6083): 925--931 Multiple spectral inputs improve motion discrimination in the Drosophila visual system. [FBrf0218379] Wernet et al., 2012, Curr. Biol. 22(1): 12--20 Genetic dissection reveals two separate retinal substrates for polarization vision in Drosophila. [FBrf0217218] Johnston et al., 2011, Cell 145(6): 956--968 Interlocked feedforward loops control cell-type-specific rhodopsin expression in the Drosophila eye. [FBrf0213864] Keene et al., 2011, J. Neurosci. 31(17): 6527--6534 Distinct visual pathways mediate Drosophila larval light avoidance and circadian clock entrainment. [FBrf0213587] Klarsfeld et al., 2011, J. Neurosci. 31(48): 17406--17415 Identifying specific light inputs for each subgroup of brain clock neurons in Drosophila larvae. [FBrf0216850] Luo et al., 2011, Development 138(13): 2761--2771 Direct targets of the D. melanogaster DSXF protein and the evolution of sexual development. [FBrf0213878] Rosenbaum et al., 2011, Neuron 72(4): 602--615 XPORT-Dependent Transport of TRP and Rhodopsin. [FBrf0216705] Shen et al., 2011, Science 331(6022): 1333--1336 Function of rhodopsin in temperature discrimination in Drosophila. [FBrf0213227] Sprecher et al., 2011, Dev. Biol. 358(1): 33--43 The Drosophila larval visual system: High-resolution analysis of a simple visual neuropil. [FBrf0215208] Vasiliauskas et al., 2011, Nature 479(7371): 108--112 Feedback from rhodopsin controls rhodopsin exclusion in Drosophila photoreceptors. [FBrf0216554] Yuan et al., 2011, Science 333(6048): 1458--1462 Light-induced structural and functional plasticity in Drosophila larval visual system. [FBrf0215276] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...