A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\Rho1

General Information
SymbolDmel\Rho1SpeciesD. melanogaster
NameRho1Annotation symbolCG8416
Feature typeprotein_coding_geneFlyBase IDFBgn0014020
Gene Model StatusCurrent Stock availability 37 publicly available
Also Known AsRhoA, Rho, dRhoA, DRho1, Rho kinase, Rho GTPase
Genomic Location
Chromosome (arm)2RRecombination map2-
Cytogenetic map52E5-52E5Sequence location2R:11,990,191..11,994,734 [+]

Genomic Maps

GBrowse View Help
modENCODE GBrowse
detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene Rho1 is referred to in FlyBase by the symbol Dmel\Rho1 (CG8416, FBgn0014020). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; kinase binding. There is experimental evidence for 40 unique biological process terms, many of which group under: cellular component organization or biogenesis; biological regulation; localization; embryonic development via the syncytial blastoderm; open tracheal system development; cellular component movement; actin filament-based process; embryo development ending in birth or egg hatching; neuron differentiation; anatomical structure formation involved in morphogenesis; response to stress. 68 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; non-connected developing system; external compound sense organ; extended germ band embryo; late extended germ band embryo; peripheral nervous system; portion of tissue; spiracle; embryonic hindgut; adult segment. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Small GTP-binding protein domain; Small GTPase superfamily; Small GTPase superfamily, Rho type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Gene sequence location is 2R:11990191..11994734.

External Summaries
hide Recent Updates
Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Update Feed
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
Controlled Vocabulary Terms
References
FB2012_01
References
Sequence features
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
52E5-52E5  
Limits computationally determined from genome sequence between P{PZ}l(2)0507005070&P{EP}CG8414EP525 and P{EP}spinEP645&P{lacW}spink09905  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
 
Cytological location reported in FBrf0080078 was in error.  
 
52E-52E  
52E-52E  
(determined by in situ hybridisation)  
52E5-52E6  
(determined by in situ hybridisation)  
52E3-52E6  
(determined by in situ hybridisation)  
52D-52D  
(determined by in situ hybridisation)  
3C-3C  
(determined by in situ hybridisation)  
52E2-52E9  
Hybridization of Rho1 cDNA to Df(2R)KL32 and Df(2R)Jp6 confirmed that Rho1 maps to 52E. (determined by in situ hybridisation)  
52E3-52E6  
Cytological location reported in FBrf0080078 was in error. (determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
2-
 
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\Rho1 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0087255 FBtr0087216 FBtr0087211 FBtr0087212 FBtr0087213 FBtr0087215 FBtr0087217 FBtr0087214 FBtr0300576 FBtr0087254 FBpp0086393 FBpp0089130 FBpp0086354 FBpp0089128 FBpp0089129 FBpp0086353 FBpp0086356 FBpp0086355 FBpp0086392 FBpp0289803 FBti0045017 FBti0112631 FBti0007616 FBti0010042 FBti0024167 FBti0111639 FBti0110573 FBti0033605 FBti0104917 FBti0026385 FBti0059280 FBti0004363 FBti0069686 FBti0069774 FBti0113460 FBti0054824 FBti0064853 FBti0064743 FBti0064741 FBti0064748 FBti0043029 FBti0072326
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0087211
  1195
  192
FBtr0087212
  2029
  192
FBtr0087213
  1798
  192
FBtr0087214
  1983
  192
FBtr0087215
  763
  192
FBtr0087216
  1972
  192
FBtr0087217
  1975
  192
Additional Transcript Data & Comments
Reported size (kB)
3.7, 3.1, 2.1 (northern blot); 1.3 (unknown)
1.467 (longest cDNA)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0086353  
21.7  
192  
7.06  
FBpp0086354  
21.7  
192  
7.06  
FBpp0086355  
21.7  
192  
7.06  
FBpp0086356  
21.7  
192  
7.06  
FBpp0089128  
21.7  
192  
7.06  
FBpp0089129  
21.7  
192  
7.06  
FBpp0089130  
21.7  
192  
7.06  
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Comment:female
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view CG8414-RA Rho1-RF Rho1-RA Rho1-RB Rho1-RC Rho1-RE Rho1-RG Rho1-RD Ric-RB Ric-RA
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0014020


   Styles
Linear
Logarithmic
Heatmap
   Scales
max expr for FBgn0014020
Very low expression bin max
Moderate expression bin max
High expression bin max
Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No expression (0 - 0)
 
Extremely low expression (1 - 10)
 
Very low expression (11 - 100)
 
Low expression (101 - 400)
 
Moderate expression (401 - 1400)
 
Moderately high expression (1401 - 4000)
 
High expression (4001 - 10000)
 
Very high expression (10001 - 100000)
 
Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0014020 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 6130
embryo 02-04hr
 
 11433
embryo 04-06hr
 
 14551
embryo 06-08hr
 
 14420
embryo 08-10hr
 
 14984
embryo 10-12hr
 
 15985
embryo 12-14hr
 
 18244
embryo 14-16hr
 
 9004
embryo 16-18hr
 
 12340
embryo 18-20hr
 
 8516
embryo 20-22hr
 
 7958
embryo 22-24hr
 
 11143
larva L1
 
 7973
larva L2
 
 7965
larva L3 12hr old
 
 7477
larva L3 puffstage 1-2
 
 9330
larva L3 puffstage 3-6
 
 13618
larva L3 puffstage 7-9
 
 19934
white prepupae new
 
 19322
white prepupae 12hr
 
 15727
white prepupae 24hr
 
 13618
pupae 2d postWPP
 
 11758
pupae 3d postWPP
 
 7930
pupae 4d postWPP
 
 5214
adult male 01day
 
 6468
adult male 05day
 
 6074
adult male 30day
 
 5846
adult female 01day
 
 5335
adult female 05day
 
 7177
adult female 30day
 
 7020
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (6130)
embryo 02-04hr
 (11433)
embryo 04-06hr
 (14551)
embryo 06-08hr
 (14420)
embryo 08-10hr
 (14984)
embryo 10-12hr
 (15985)
embryo 12-14hr
 (18244)
embryo 14-16hr
 (9004)
embryo 16-18hr
 (12340)
embryo 18-20hr
 (8516)
embryo 20-22hr
 (7958)
embryo 22-24hr
 (11143)
larva L1
 (7973)
larva L2
 (7965)
larva L3 12hr old
 (7477)
larva L3 puffstage 1-2
 (9330)
larva L3 puffstage 3-6
 (13618)
larva L3 puffstage 7-9
 (19934)
white prepupae new
 (19322)
white prepupae 12hr
 (15727)
white prepupae 24hr
 (13618)
pupae 2d postWPP
 (11758)
pupae 3d postWPP
 (7930)
pupae 4d postWPP
 (5214)
adult male 01day
 (6468)
adult male 05day
 (6074)
adult male 30day
 (5846)
adult female 01day
 (5335)
adult female 05day
 (7177)
adult female 30day
 (7020)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (6130)
embryo 02-04hr
 (11433)
embryo 04-06hr
 (14551)
embryo 06-08hr
 (14420)
embryo 08-10hr
 (14984)
embryo 10-12hr
 (15985)
embryo 12-14hr
 (18244)
embryo 14-16hr
 (9004)
embryo 16-18hr
 (12340)
embryo 18-20hr
 (8516)
embryo 20-22hr
 (7958)
embryo 22-24hr
 (11143)
larva L1
 (7973)
larva L2
 (7965)
larva L3 12hr old
 (7477)
larva L3 puffstage 1-2
 (9330)
larva L3 puffstage 3-6
 (13618)
larva L3 puffstage 7-9
 (19934)
white prepupae new
 (19322)
white prepupae 12hr
 (15727)
white prepupae 24hr
 (13618)
pupae 2d postWPP
 (11758)
pupae 3d postWPP
 (7930)
pupae 4d postWPP
 (5214)
adult male 01day
 (6468)
adult male 05day
 (6074)
adult male 30day
 (5846)
adult female 01day
 (5335)
adult female 05day
 (7177)
adult female 30day
 (7020)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 6130
embryo 02-04hr
 (11433)
embryo 04-06hr
 (14551)
embryo 06-08hr
 (14420)
embryo 08-10hr
 (14984)
embryo 10-12hr
 (15985)
embryo 12-14hr
 (18244)
embryo 14-16hr
 
 9004
embryo 16-18hr
 (12340)
embryo 18-20hr
 
 8516
embryo 20-22hr
 
 7958
embryo 22-24hr
 (11143)
larva L1
 
 7973
larva L2
 
 7965
larva L3 12hr old
 
 7477
larva L3 puffstage 1-2
 
 9330
larva L3 puffstage 3-6
 (13618)
larva L3 puffstage 7-9
 (19934)
white prepupae new
 (19322)
white prepupae 12hr
 (15727)
white prepupae 24hr
 (13618)
pupae 2d postWPP
 (11758)
pupae 3d postWPP
 
 7930
pupae 4d postWPP
 
 5214
adult male 01day
 
 6468
adult male 05day
 
 6074
adult male 30day
 
 5846
adult female 01day
 
 5335
adult female 05day
 
 7177
adult female 30day
 
 7020
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 6130
embryo 02-04hr
 
 11433
embryo 04-06hr
 
 14551
embryo 06-08hr
 
 14420
embryo 08-10hr
 
 14984
embryo 10-12hr
 
 15985
embryo 12-14hr
 
 18244
embryo 14-16hr
 
 9004
embryo 16-18hr
 
 12340
embryo 18-20hr
 
 8516
embryo 20-22hr
 
 7958
embryo 22-24hr
 
 11143
larva L1
 
 7973
larva L2
 
 7965
larva L3 12hr old
 
 7477
larva L3 puffstage 1-2
 
 9330
larva L3 puffstage 3-6
 
 13618
larva L3 puffstage 7-9
 
 19934
white prepupae new
 
 19322
white prepupae 12hr
 
 15727
white prepupae 24hr
 
 13618
pupae 2d postWPP
 
 11758
pupae 3d postWPP
 
 7930
pupae 4d postWPP
 
 5214
adult male 01day
 
 6468
adult male 05day
 
 6074
adult male 30day
 
 5846
adult female 01day
 
 5335
adult female 05day
 
 7177
adult female 30day
 
 7020
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to maximum FBgn0014020 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 6130
embryo 02-04hr
 
 11433
embryo 04-06hr
 
 14551
embryo 06-08hr
 
 14420
embryo 08-10hr
 
 14984
embryo 10-12hr
 
 15985
embryo 12-14hr
 
 18244
embryo 14-16hr
 
 9004
embryo 16-18hr
 
 12340
embryo 18-20hr
 
 8516
embryo 20-22hr
 
 7958
embryo 22-24hr
 
 11143
larva L1
 
 7973
larva L2
 
 7965
larva L3 12hr old
 
 7477
larva L3 puffstage 1-2
 
 9330
larva L3 puffstage 3-6
 
 13618
larva L3 puffstage 7-9
 
 19934
white prepupae new
 
 19322
white prepupae 12hr
 
 15727
white prepupae 24hr
 
 13618
pupae 2d postWPP
 
 11758
pupae 3d postWPP
 
 7930
pupae 4d postWPP
 
 5214
adult male 01day
 
 6468
adult male 05day
 
 6074
adult male 30day
 
 5846
adult female 01day
 
 5335
adult female 05day
 
 7177
adult female 30day
 
 7020
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 (6130)
embryo 02-04hr
 (11433)
embryo 04-06hr
 (14551)
embryo 06-08hr
 (14420)
embryo 08-10hr
 (14984)
embryo 10-12hr
 (15985)
embryo 12-14hr
 (18244)
embryo 14-16hr
 (9004)
embryo 16-18hr
 (12340)
embryo 18-20hr
 (8516)
embryo 20-22hr
 (7958)
embryo 22-24hr
 (11143)
larva L1
 (7973)
larva L2
 (7965)
larva L3 12hr old
 (7477)
larva L3 puffstage 1-2
 (9330)
larva L3 puffstage 3-6
 (13618)
larva L3 puffstage 7-9
 (19934)
white prepupae new
 (19322)
white prepupae 12hr
 (15727)
white prepupae 24hr
 (13618)
pupae 2d postWPP
 (11758)
pupae 3d postWPP
 (7930)
pupae 4d postWPP
 (5214)
adult male 01day
 (6468)
adult male 05day
 (6074)
adult male 30day
 (5846)
adult female 01day
 (5335)
adult female 05day
 (7177)
adult female 30day
 (7020)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 (6130)
embryo 02-04hr
 (11433)
embryo 04-06hr
 (14551)
embryo 06-08hr
 (14420)
embryo 08-10hr
 (14984)
embryo 10-12hr
 (15985)
embryo 12-14hr
 (18244)
embryo 14-16hr
 (9004)
embryo 16-18hr
 (12340)
embryo 18-20hr
 (8516)
embryo 20-22hr
 (7958)
embryo 22-24hr
 (11143)
larva L1
 (7973)
larva L2
 (7965)
larva L3 12hr old
 (7477)
larva L3 puffstage 1-2
 (9330)
larva L3 puffstage 3-6
 (13618)
larva L3 puffstage 7-9
 (19934)
white prepupae new
 (19322)
white prepupae 12hr
 (15727)
white prepupae 24hr
 (13618)
pupae 2d postWPP
 (11758)
pupae 3d postWPP
 (7930)
pupae 4d postWPP
 (5214)
adult male 01day
 (6468)
adult male 05day
 (6074)
adult male 30day
 (5846)
adult female 01day
 (5335)
adult female 05day
 (7177)
adult female 30day
 (7020)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 6130
embryo 02-04hr
 11433
embryo 04-06hr
 14551
embryo 06-08hr
 14420
embryo 08-10hr
 14984
embryo 10-12hr
 15985
embryo 12-14hr
 18244
embryo 14-16hr
 
 9004
embryo 16-18hr
 12340
embryo 18-20hr
 
 8516
embryo 20-22hr
 
 7958
embryo 22-24hr
 11143
larva L1
 
 7973
larva L2
 
 7965
larva L3 12hr old
 
 7477
larva L3 puffstage 1-2
 
 9330
larva L3 puffstage 3-6
 13618
larva L3 puffstage 7-9
 19934
white prepupae new
 19322
white prepupae 12hr
 15727
white prepupae 24hr
 13618
pupae 2d postWPP
 11758
pupae 3d postWPP
 
 7930
pupae 4d postWPP
 
 5214
adult male 01day
 
 6468
adult male 05day
 
 6074
adult male 30day
 
 5846
adult female 01day
 
 5335
adult female 05day
 
 7177
adult female 30day
 
 7020
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 6130
embryo 02-04hr
 
 11433
embryo 04-06hr
 
 14551
embryo 06-08hr
 
 14420
embryo 08-10hr
 
 14984
embryo 10-12hr
 
 15985
embryo 12-14hr
 
 18244
embryo 14-16hr
 
 9004
embryo 16-18hr
 
 12340
embryo 18-20hr
 
 8516
embryo 20-22hr
 
 7958
embryo 22-24hr
 
 11143
larva L1
 
 7973
larva L2
 
 7965
larva L3 12hr old
 
 7477
larva L3 puffstage 1-2
 
 9330
larva L3 puffstage 3-6
 
 13618
larva L3 puffstage 7-9
 
 19934
white prepupae new
 
 19322
white prepupae 12hr
 
 15727
white prepupae 24hr
 
 13618
pupae 2d postWPP
 
 11758
pupae 3d postWPP
 
 7930
pupae 4d postWPP
 
 5214
adult male 01day
 
 6468
adult male 05day
 
 6074
adult male 30day
 
 5846
adult female 01day
 
 5335
adult female 05day
 
 7177
adult female 30day
 
 7020
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

FlyAtlas Anatomical Expression Data for FBgn0014020


   Styles
Linear
Logarithmic
Heatmap
Back-to-back
   Scales
max expr for FBgn0014020
Moderate expression bin max
High level expression bin max
Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (1000 - 25000)

Heatmap
Tissue   Expression Level
Larval Central Nervous System no informative data
Larval Midgut no informative data
Larval Hindgut no informative data
Larval Malpighian Tubules no informative data
Larval Fat Body no informative data
Larval Salivary Gland no informative data
Larval Trachea no informative data
Larval Carcass no informative data
Adult Head no informative data
Adult Eye no informative data
Adult Brain no informative data
Adult Thoracic-Abdominal Ganglion no informative data
Adult Crop no informative data
Adult Midgut no informative data
Adult Hindgut no informative data
Adult Malpighian Tubules no informative data
Adult Fat Body no informative data
Adult Salivary Gland no informative data
Adult Heart no informative data
Adult VirginFemale Spermatheca no informative data
Adult InseminatedFemale Spermatheca no informative data
Adult Ovary no informative data
Adult Testis no informative data
Adult Male Accessory Gland no informative data
Adult Carcass no informative data

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyExpress - Embryonic expression images (BDGP data)
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
actin filament & embryonic/larval tracheal system, with Scer\GAL4btl.PS
cortical actin cytoskeleton & embryonic posterior spiracle, with Scer\GAL4ems.HRE
cortical actin cytoskeleton & spiracular chamber (with Rho11B)
cortical actin cytoskeleton & spiracular chamber (with Rho172R)
cortical actin cytoskeleton & syncytial blastoderm embryo | maternal effect
disc epithelium proper & dorsal mesothoracic disc, with Scer\GAL4ptc-559.1
embryonic/first instar larval cuticle & embryonic head
eye disc & photoreceptor cell & axon, with Scer\GAL4GMR.PF
eye disc & subretinal glial cell, with Scer\GAL4GMR.PF
mitotic telophase & spindle
mushroom body & dendrite, with Scer\GAL4Tab2-201Y
mushroom body & dendrite | somatic clone
mushroom body & dendrite | somatic clone, with Scer\GAL4Tab2-201Y
mushroom body & neuron | somatic clone
sensory neuron & axon, with Scer\GAL4repo
hide Classical Alleles ( 34 )
For All Classical Alleles Show

Allele of Rho1ClassMutagenStocksKnown lesion
Rho1E3.10loss of function allele
2 Yes
Rho1KG01774
2 --
Rho11Bloss of function allele1 Yes
Rho172F1 Yes
Rho172O1 Yes
Rho1c001221 --
Rho1c002521 --
Rho1CB-6645-3
1 --
Rho1d023251 --
Rho1k02107b1 Yes
Rho1NP0324
1 --
Rho112-60 --
Rho172BHhypomorphic allele - genetic evidence0 Yes
Rho172M1hypomorphic allele - genetic evidence0 Yes
Rho172Rloss of function allele, hypomorphic allele - genetic evidence0 Yes
Rho179-3
0 --
Rho1BH
0 --
Rho1c002630 --
Rho1c002820 --
Rho1c007630 --
Rho1d072240 --
Rho1d075110 --
Rho1Df236
0 --
Rho1Df903
0 --
Rho1E.10
0 --
Rho1Ebr2330 --
Rho1Ebr2460 --
Rho1J3.8
0 Yes
Rho1k02107rev50 Yes
Rho1k072360 Yes
Rho1k079030 Yes
Rho1L30 Yes
Rho1rev220
0 Yes
Rho1unspecified
0 --
hide Alleles Carried on Transgenic Constructs ( 34 )
For All Alleles Carried on Transgenic Constructs Show

Allele of Rho1ClassMutagenStocksKnown lesion
Rho1T:Avic\GFP3 Yes
Rho1dsRNA.Scer\UAS2 Yes
Rho1N19.Scer\UAS2 Yes
Rho1Scer\UAS.P\T.T:Avic\GFP2 Yes
Rho1Scer\UAS.P\T.T:Uuuu\T72 Yes
Rho1V14.E40L.Scer\UAS2 Yes
Rho1V14.Scer\UAS2 Yes
Rho1D100N.Scer\UAS.P\T.T:Uuuu\T71 Yes
Rho1dsRNA.1.Scer\UAS1 Yes
Rho1dsRNA.2.Scer\UAS1 Yes
Rho1GD47261 Yes
Rho1HMS003751 Yes
Rho1JF028091 Yes
Rho1Scer\UAS.cMa1 Yes
Rho1Scer\UAS.cWa1 Yes
Rho1V14.F39V.Scer\UAS1 Yes
Rho1+mMa0 Yes
Rho1Act5C.T:Avic\GFP-EGFP0 Yes
Rho1CA.Scer\UAS0 Yes
Rho1dsRNA.75-8210 Yes
Rho1dsRNA.cCa0 Yes
Rho1dsRNA.cHa0 Yes
Rho1dsRNA.cMa0 Yes
Rho1dsRNA.cMb0 Yes
Rho1dsRNA.cRa0 Yes
Rho1dsRNA.cSa0 Yes
Rho1GMR.PH0 Yes
Rho1KK1081820 Yes
Rho1N19.sev0 --
Rho1Scer\UAS.cHa0 Yes
Rho1Scer\UAS.T:Avic\GFP0 Yes
Rho1Scer\UAS:T:Avic\GFP-CFP0 Yes
Rho1V12.Scer\UAS0 Yes
Rho1V14.sev0 --
hide Aneuploid Aberrations
Disrupted in
Not disrupted in
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
heat-shock construct
Insertions
Type of insertions
Name
Expression data
insertion of enhancer trap binary system
hide Gene Ontology: Function, Process & Cellular Component ( 63 unique terms )
hide Terms Based on Experimental Evidence ( 48 terms )
Molecular Function
CV term
References
inferred from physical interaction with rok
inferred from physical interaction with rok
inferred from physical interaction with wash
Biological Process
CV term
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with p120ctn
inferred from genetic interaction with stan
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with fz
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with LIMK1
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Cellular Component
CV term
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
hide Terms Based on Predictions or Assertions ( 19 terms )
Molecular Function
CV term
References
inferred from sequence or structural similarity
inferred from sequence or structural similarity with EMBL:AF014371
non-traceable author statement
traceable author statement
Biological Process
CV term
References
traceable author statement
traceable author statement
non-traceable author statement
traceable author statement
non-traceable author statement
non-traceable author statement
non-traceable author statement
non-traceable author statement
traceable author statement
non-traceable author statement
Cellular Component ( 0 terms)
hide Sequence Ontology: Class of Gene
hide Interactions & Pathways
hide Summary of Physical Interactions
Protein-protein
Interacting group
Assay
References
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
Rho1 allele
Gene
References
hide External Data
Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
InParanoid A subset of ortholog calls from InParanoid.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 37 )
Bloomington
Harvard
hide Genomic Clones ( 2 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 148 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
hide Antibody Information
hide Other Information
hide Discoverer
hide Etymology
hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for database merge of
Source for merge of: Rho1 l(2)52Fa
Source for merge of: Rho1 l(2)k02107b
Additional comments
hide Other Comments
Rho1 is an upstream regulator of DAAM.
The active Rho1 product promotes microtubule/microfilament crosslinking by sequestering the spir-PD isoform, preventing this protein from binding to spir-PC and capu.
Rho1 regulates shg but not arm localisation and the effect of loss of Rho1 is not enhanced or suppressed by removing p120ctn.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes no cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells with increased or polarized (uneven) accumulation of F-actin.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Rho1 and Rac1 mediate the dynamic rearrangement of actin in peripheral glia.
Rho1 appears to be required for the regulation of actin polymerisation and/or myosin activity that is critical for thr response of growth cones to midline repulsive signals.
Rho1 is necessary for normal morphology and behaviour of the leading edge cells during embryonic dorsal closure.
Rho1 is necessary for actin cable formation, but not cellular extenion formation during wound healing in the embryo.
Rho1 is required for neuroblast proliferation but not for neuronal survival in the mushroom body.
Together with Pkn, Rho1 mediates a pathway for cell shape changes in dorsal closure that is independent of the Rac GTPase-mediated Jun amino (N)-terminal kinase (JNK) cascade.
Rho1 is required for many early events, both maternally and zygotically. Rho1 does not interact with members of the JNK signalling pathway.
pbl is linked through Rho1 activity to the reorganisation of the actin cytoskeleton.
Rho1 is required for invagination of mesodermal and endodermal primordia during gastrulation and its activation is likely to be regulated by RhoGEF2.
Complements S.cerevisiae RHO1 mutation.
Rho1 has been cloned and sequenced. Rho1 is required for the generation of tissue polarity. Genetic interactions indicate that Rho1 has a role in signalling mediated by fz and dsh.
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Linkouts
BioGRID - A database of protein and genetic interactions
DPiM - DPiM, Drosophila Protein interaction Map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
InParanoid A subset of ortholog calls from InParanoid.
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Synonyms & Secondary IDs ( 32 )
Reported As
Symbol Synonym
AAF01186
Dm Rho1
l(2)52Fa
 
Rho
(McClatchey and Giovannini, 2005, Grzeschik and Knust, 2005, D'Avino et al., 2004, Fan et al., 2003, Bejsovec, 2005, Manning et al., 2002, Talbot and VanBerkum, 2005, Stewart and Ward, 2005, Rosales-Nieves et al., 2005, Jefferson et al., 2004, Stramer et al., 2004, Keung et al., 2004, Fox et al., 2004, Finn and Fehon, 2004, Avet-Rochex et al., 2004, Jekely, 2003, Bashaw et al., 2001, Shilo, 2003, Baum, 2002, Jacinto et al., 2001, Bokel and Brown, 2002, Etienne-Manneville and Hall, 2002, Speck et al., 2003, Matani et al., 2003, Park et al., 2002, Strutt et al., 2002, Fritz and Vanberkum, 2001, Fritz and VanBerkum, 2001, Bashaw et al., 2001, Jacinto and Martin, 2001, Johnson et al., 2001, Guichard et al., 2001, Chen et al., 2001, Bee et al., 2001, Chang and Ready, 2000, Luo, 2000, Seidensticker and Behrens, 2000, Bloor and Kiehart, 2000, Chen et al., 2000, Martin-Bermudo et al., 1999, Frasch, 1999, Montell, 1999, Crawford et al., 1998, Sutherland and Witke, 1999, Magie et al., 1999, Kerber et al., 1998, Bloor and Kiehart, 1998, O'Leary et al., 1998, Meyer and Parkhurst, 1997, Meyer and Parkhurst, 1997, Xu et al., 2006, Stewart et al., 2006, Kolesnikov, 2006, Homem et al., 2006, Xu et al., 2007, Artabazon et al., 2007, Talbot and VanBerkum, 2006, Fehon, 2006, Emery et al., 2005, Stramer et al., 2005, Gregory et al., 2007, Hozumi et al., 2006, Elsaesser et al., 2010, Warren-Paquin et al., 2008, Avet-Rochex et al., 2007, Ng, 2008, Yang and Bashaw, 2006, Schotman et al., 2009, Gupta et al., 2009, Larson et al., 2008, Homem and Peifer, 2009, Uehara et al., 2010, Goldbach et al., 2010, Blanchard et al., 2010, He et al., 2010, Ball et al., 2010)
Rho1
(Sweeney et al., 2008, Aleksic et al., 2009, Wenzl and Grosshans, 2007, Neisch et al., 2007, Mulinari et al., 2007, Zhang et al., 2007, Fox et al., 2005, Luo, 2007.3.23, Padash Barmchi et al., 2005, Stramer et al., 2005, Brodu and Casanova, 2006, Rogers et al., 2003, Sommer et al., 2005, Vidal et al., 2006, Simoes et al., 2006, Avet-Rochex et al., 2005, Dean and Spudich, 2006, Kadandale et al., 2010, He et al., 2005, Lovegrove et al., 2006, Quinones-Coello, 2007, Bakal et al., 2007, Fox and Peifer, 2007, Polaski et al., 2006, Patch et al., 2008, Artabazon et al., 2008, Benjamin et al., 2008, Xu et al., 2008, Morgan and Kalm, 2008, Koelsch and Leptin, 2008, Bakal et al., 2007, Vig et al., 2006, Larson et al., 2008, Chen et al., 2005, Minidorff et al., 2007, Zhou et al., 2008, Betson and Settleman, 2007, Minidorff et al., 2007, Hickson and O'Farrell, 2008, Johnson et al., 2008, Taniguchi et al., 2007, Homem and Peifer, 2008, Paladi and Tepass, 2004, Williams et al., 2007, Matusek et al., 2008, Xu et al., 2008, Alves-Silva et al., 2008, Frank et al., 2009, Webb et al., 2009, Widmann and Dahmann, 2009, Snee and Macdonald, 2009, Dworkin et al., 2009, Liu et al., 2009, Asensio et al., 2010, Massarwa et al., 2009, Yan et al., 2009, Zeitlinger et al., 2007, Cordero et al., 2007, Warner and Longmore, 2009, Rothenfluh et al., 2006, Mirouse et al., 2009, Warner and Longmore, 2009, Patch et al., 2009, Sato et al., 2010, Zimmerman et al., 2010, Campos et al., 2010, Sekyrova et al., 2010, Pataki et al., 2010, Neisch et al., 2010, von Hilchen et al., 2010, Renault et al., 2010, Warner, 2010.9.15, Blanchard et al., 2010, Wang and Riechmann, 2007, Yu et al., 2010, Beltran et al., 2007, Song and Giniger, 2011, Simões et al., 2010, Tanaka et al., 2011, van Impel et al., 2009, Hughes et al., 2010, Ball et al., 2010)
RhoA
(Kerkhoff, 2006, Hu, 2005, Zhu et al., 2005, Govek, 2005, Wilson et al., 2005, Shandala et al., 2004, Harden et al., 2002, Balasubramanian et al., 2004, Wilk et al., 2004, Ishimaru et al., 2004, Polesello and Payre, 2004, Strutt and Strutt, 2003, Goda and Davis, 2003, Starz-Gaiano and Montell, 2004, Bayer et al., 2003, Ghabrial et al., 2003, Halsell et al., 2004, Jacinto and Baum, 2003, Solnica-Krezel and Eaton, 2003, Strutt, 2003, Strutt and Strutt, 2003, Pasterkamp and Kolodkin, 2003, Adler and Lee, 2001, Patel and Van Vactor, 2002, Wood et al., 2002, Acebes and Ferrus, 2000, Gao and Bogert, 2003, Echard and O'Farrell, 2003, Adler, 2002, Tree et al., 2002, Mlodzik, 2002, Aigaki et al., 2002, Tan et al., 2003, Castellani and Rougon, 2002, Wedlich, 2002, Lee et al., 2003, Schumacher et al., 2003, von Kalm et al., 2002, Bloor and Kiehart, 2002, Strutt et al., 2002, Kolodziej and Lee, 2002, Bloor and Kiehart, 2001, Wiemann et al., 2001, O'Keefe et al., 2000, Lee and Kolodziej, 2002, Billuart et al., 2001, Whitford and Ghosh, 2001, Bloor and Kiehart, 2001, Johnstone and Lasko, 2001, Hu et al., 2001, Billuart et al., 2001, Cooper and Strutt, 2001, Das and Mlodzik, 2001, Strutt, 2001, Winter et al., 2001, Winter et al., 2001, Pilch et al., 2001, Somers et al., 2001, Uchida et al., 2001, Sotillos and Campuzano, 2000, Fanto, 2000, Fanto et al., 2000, Newsome et al., 2000, Halsell et al., 2000, Pazman et al., 2000, Mlodzik, 2000, Lee et al., 2000, Halsell and Kiehart, 2000, Peifer and Tepass, 2000, Mlodzik, 1999, Kollmar, 1999, Rangarajan et al., 1999, Paricio et al., 1999, Sawamoto et al., 1999, Thomas and Wassarman, 1999, Reifegerste and Moses, 1999, Sawamoto et al., 1999, Sutherland and Witke, 1999, Lee et al., 1999, Harden et al., 1999, Harden et al., 1999, Halsell and Kiehart, 1999, Asha et al., 1999, Goberdhan and Wilson, 1998, Shulman et al., 1998, Boutros et al., 1998, Tree and Gubb, 1998, Axelrod et al., 1998, Dale, 1998, Strutt et al., 1997, Martin-Blanco, 1997, Eaton, 1997, Van Aelst and D'Souza-Schorey, 1997, Strutt et al., 1997, Ng and Luo, 2005, Matusek et al., 2005, Ruggiero et al., 2006, Fox and Kalm, 2006, Tyler et al., 2007, Impel et al., 2007, Matusek et al., 2006, McBride et al., 2006, Gregory et al., 2007, Mirkovic and Mlodzik, 2006, Roubinet et al., 2007, Nahm et al., 2006, Tolwinski, 2007, Sanny et al., 2006, Chung et al., 2007, Srahna et al., 2006, Mirkovic et al., 2011, Morgan and Kalm, 2008, Gregory et al., 2008, D'Avino et al., 2005, Taniguchi et al., 2007, Montrasio et al., 2007, Corrigall et al., 2007, Bastock and Strutt, 2007, Piekny et al., 2005, Carreno et al., 2008, Albertson et al., 2008, Cao et al., 2008, Llense and Martín-Blanco, 2008, Minin et al., 2006, Bidla et al., 2007, Rodriguez-Diaz et al., 2008, Schotman et al., 2009, Franke et al., 2007, Cao et al., 2010, Pataki et al., 2010, Matusek et al., 2008, Blanchard et al., 2010, Colinet et al., 2010, Zeng et al., 2010, Ben El Kadhi et al., 2011, Matsubara et al., 2011)
Name Synonym
Secondary FlyBase IDs
  • FBgn0014021
  • FBgn0024874
  • FBgn0024880
hide References ( 489 )
Generate a list of
List References by type
hide Recent research papers ( 35 )
Bassi et al., 2011, J. Cell Biol. 195(4): 595--603
Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis. [FBrf0216679]
Ben El Kadhi et al., 2011, Curr. Biol. 21(12): 1074--1079
The Inositol 5-Phosphatase dOCRL Controls PI(4,5)P2 Homeostasis and Is Necessary for Cytokinesis. [FBrf0213972]
Horn et al., 2011, Nat. Methods 8(4): 341--346
Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352]
Koppen et al., 2011, Proteomics 11(22): 4397--4410
Proteomics analyses of microvesicles released by Drosophila Kc167 and S2 cells. [FBrf0216610]
Matsubara et al., 2011, Genes Dev. 25(18): 1982--1996
The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons. [FBrf0215818]
Pilgram et al., 2011, J. Neurosci. 31(2): 492--500
The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767]
Pollarolo et al., 2011, Nat. Neurosci. 14(12): 1525--1533
Cytokinesis remnants define first neuronal asymmetry in vivo. [FBrf0216761]
Song and Giniger, 2011, Dev. Dyn. 240(2): 324--332
Noncanonical notch function in motor axon guidance is mediated by Rac GTPase and the GEF1 domain of trio. [FBrf0212819]
Tanaka et al., 2011, Development 138(12): 2523--2532
Drosophila Mon2 couples Oskar-induced endocytosis with actin remodeling for cortical anchorage of the germ plasm. [FBrf0213769]
Vanzomeren-Dohm et al., 2011, BMC Dev. Biol. 11: 41
The Drosophila Netrin receptor frazzled/DCC functions as an invasive tumor suppressor. [FBrf0214535]
Asensio et al., 2010, J. Cell Biol. 191(6): 1173--1187
RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. [FBrf0212515]
Ball et al., 2010, Neuron 66(4): 536--549
Retrograde BMP Signaling Controls Synaptic Growth at the NMJ by Regulating Trio Expression in Motor Neurons. [FBrf0210920]
Blanchard et al., 2010, Development 137(16): 2743--2752
Cytoskeletal dynamics and supracellular organisation of cell shape fluctuations during dorsal closure. [FBrf0211395]
Campos et al., 2010, Genetics 184(1): 129--140
Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. [FBrf0209682]
Cao et al., 2010, Curr. Biol. 20(8): 770--776
Cortical Actin Dynamics Facilitate Early-Stage Centrosome Separation. [FBrf0211162]
Colinet et al., 2010, PLoS Pathog. 6(11): e1001206
The origin of intraspecific variation of virulence in an eukaryotic immune suppressive parasite. [FBrf0212464]
Djiane and Mlodzik, 2010, PLoS ONE 5(6): e11228
The Drosophila GIPC homologue can modulate myosin based processes and planar cell polarity but is not essential for development. [FBrf0211141]
Elsaesser et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(10): 4740--4745
Light-induced translocation of Drosophila visual Arrestin2 depends on Rac2. [FBrf0210213]
Goldbach et al., 2010, Mol. Biol. Cell 21(9): 1482--1493
Stabilization of the actomyosin ring enables spermatocyte cytokinesis in Drosophila. [FBrf0210683]
He et al., 2010, Nat. Cell Biol. 12(12): 1133--1142
Tissue elongation requires oscillating contractions of a basal actomyosin network. [FBrf0212453]
Hughes et al., 2010, J. Cell Sci. 123(7): 1099--1107
Sip1, the Drosophila orthologue of EBP50/NHERF1, functions with the sterile 20 family kinase Slik to regulate Moesin activity. [FBrf0210408]
Kadandale et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(23): 10502--10507
Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment. [FBrf0210996]
Neisch et al., 2010, J. Cell Biol. 189(2): 311--323
Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane. [FBrf0210554]
Neubueser and Hipfner, 2010, Mol. Biol. Cell 21(16): 2869--2879
Overlapping roles of Drosophila drak and rok kinases in epithelial tissue morphogenesis. [FBrf0211530]
Pataki et al., 2010, Genetics 184(4): 1051--1065
Drosophila Rab23 is involved in the regulation of the number and planar polarization of the adult cuticular hairs. [FBrf0210720]
Renault et al., 2010, Development 137(11): 1815--1823
Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila. [FBrf0210764]
Sato et al., 2010, Genes Cells 15(5): 485--500
Crossveinless-c, the Drosophila homolog of tumor suppressor DLC1, regulates directional elongation of dendritic branches via down-regulating Rho1 activity. [FBrf0211000]
Sekyrova et al., 2010, Development 137(1): 141--150
Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis. [FBrf0209550]
Shao et al., 2010, PLoS ONE 5(4): e9938
A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium. [FBrf0210449]
Simões et al., 2010, Dev. Cell 19(3): 377--388
Rho-Kinase Directs Bazooka/Par-3 Planar Polarity during Drosophila Axis Elongation. [FBrf0211783]
Uehara et al., 2010, Curr. Biol. 20(12): 1080--1085
Determinants of Myosin II Cortical Localization during Cytokinesis. [FBrf0211160]
von Hilchen et al., 2010, Development 137(8): 1251--1262
Netrins guide migration of distinct glial cells in the Drosophila embryo. [FBrf0210391]
Yu et al., 2010, J. Neurosci. 30(36): 12151--12156
Plexin a-semaphorin-1a reverse signaling regulates photoreceptor axon guidance in Drosophila. [FBrf0211784]
Zeng et al., 2010, J. Cell. Physiol. 224(3): 766--774
Tumor suppressors Sav/scrib and oncogene ras regulate stem-cell transformation in adult Drosophila malpighian tubules. [FBrf0211181]
Zimmerman et al., 2010, Dev. Biol. 340(1): 54--66
Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II. [FBrf0210185]
hide Recent reviews ( 1 )
Gregory et al., 2010, IUBMB Life 62(4): 290--295
Signalling through the RhoGEF Pebble in Drosophila. [FBrf0210431]