Gene Dmel\Rho1
| General Information | |||
|---|---|---|---|
| Symbol | Dmel\Rho1 | Species | D. melanogaster |
| Name | Rho1 | Annotation symbol | CG8416 |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0014020 |
| Created / Updated | 2003-12-02/2003-12-02 | ||
| Genomic Location | |||
| Chromosome (arm) | 2R | Recombination map | 2- |
| Cytogenetic map | 52E5-52E5 | Sequence location | 2R:11,990,191..11,994,734 [+] |
| Map ( GBrowse ) |
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Summary Information
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Automatically generated summary
See sections below for more information | This gene is referred to in FlyBase by the symbol Rho1 (CG8416, FBgn0014020). It has the cytological map location 52E5. Its sequence location is 2R:11990191..11994734. Its molecular function is described as: GTPase activity; protein binding; kinase binding; GTP binding. It is involved in the biological processes described with 42 unique terms, many of which group under: anatomical structure development; cell motility; actin filament-based process; open tracheal system development; organelle organization and biogenesis; cell communication; establishment of planar polarity; embryonic development via the syncytial blastoderm; imaginal disc-derived wing hair organization and biogenesis; transport; actin cable formation; transmembrane receptor protein tyrosine kinase signaling pathway; small GTPase mediated signal transduction; cell division; JNK cascade; wound healing; ommatidial rotation; Wnt receptor signaling pathway; epithelial cell differentiation; regulation of neurogenesis. 57 alleles are reported. The phenotypes of these alleles are annotated with 56 unique terms, many of which group under: organ system; peripheral nervous system; nervous system; embryonic/larval tracheal system; spiracle; extended germ band embryo; primordium; portion of tissue; embryonic nervous system; embryonic hindgut. It has 7 annotated transcripts and 7 annotated polypeptides. | ||
| External Summaries | |||
Detailed Mapping Data
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| FlyBase Computed Cytological Location | |||
Cytogenetic map Evidence for location 52E5-52E5
Limits computationally determined from genome sequence between P{PZ}l(2)0507005070&P{EP}CG8414EP525 and P{EP}spinEP645&P{lacW}spink09905
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| Experimentally Determined Cytological Location | |||
Cytogenetic map Notes References 52E-52E 52E-52E (determined by in situ hybridisation)
52E5-52E6 (determined by in situ hybridisation)
52E3-52E6 (determined by in situ hybridisation)
52E2-52E9 (determined by in situ hybridisation)
52E3-52E6 (determined by in situ hybridisation)
52D-52D (determined by in situ hybridisation)
3C-3C (determined by in situ hybridisation)
52E5-52E6 | |||
| Experimentally Determined Recombination Data | |||
| Location | 2- | ||
| Left of (cM) | |||
| Right of (cM) | |||
| Notes | |||
| Molecular Map Data | |||
Gene Order (in direction of increasing cytology)
References Gene Order (overall orientation not stated) References | |||
Gene Model & Products
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Please see the
GBrowse view of
Dmel\Rho1
for information on other features
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| Comments on Gene Model | |||
Transcript Data
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| Annotated Transcripts | |||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) | |||
| Additional Transcript Data & Comments | |||
| Reported size (kB) | 3.7, 3.1, 2.1 (northern blot); 1.3 (unknown) 1.467 (longest cDNA) | ||
| Comments | Rho1 cDNAs fall into six different classes of transcripts, all encoding the same 192 amino acid ORF. The size differences result from alternate splicing in the 5\\' and 3\\' UTRs. Four transcript sizes of 1.3, 2.1, 3.1 and 3.7 kb are detected in Northern blots; each size band probably represents multiple forms. | ||
| External Data | |||
| Crossreferences | |||
Polypeptide Data
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| Annotated Polypeptides | |||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
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| Additional Polypeptide Data & Comments | |||
| Reported size (kD) | 192 (aa) | ||
| Comments | |||
| External Data | |||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
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| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Ras GTPase (IPR001806)
Ras small GTPase, Rho type (IPR003578)
Small GTP-binding protein (IPR005225)
Ras (IPR013753)
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Sequences Consistent with the Gene Model
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| DDBJ
/
EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Maps to | |||
| Does NOT map to | |||
| Identified with | |||
Mapped Features & Mutations
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Please see
GBrowse
or insertion reports for information on insertions of transgenic
constructs and features not listed here
Type Symbol & Location Additional Notes References deletion Rho1[1B] 2R:11,991,280..11,993,556 comment=Mutation is a deletion. Upstream breakpoint is in the first intron after amino acid 52. The distal breakpoint is unknown but extends past the coding region. evidence=experimental | |||
