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Gene Dmel\Rho1

General Information
Symbol	Dmel\Rho1	Species	D. melanogaster
Name	Rho1	Annotation symbol	CG8416
Feature type	protein_coding_gene	FlyBase ID	FBgn0014020
Gene Model Status	Current	Stock availability	37 publicly available
Also Known As	RhoA, Rho, dRhoA, DRho1, Rho kinase, Rho GTPase
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	52E5-52E5	Sequence location	2R:11,990,191..11,994,734 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Rho1 is referred to in FlyBase by the symbol Dmel\Rho1 (CG8416, FBgn0014020). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; kinase binding. There is experimental evidence for 40 unique biological process terms, many of which group under: cellular component organization or biogenesis; biological regulation; localization; embryonic development via the syncytial blastoderm; open tracheal system development; cellular component movement; actin filament-based process; embryo development ending in birth or egg hatching; neuron differentiation; anatomical structure formation involved in morphogenesis; response to stress. 68 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; non-connected developing system; external compound sense organ; extended germ band embryo; late extended germ band embryo; peripheral nervous system; portion of tissue; spiracle; embryonic hindgut; adult segment. It has 7 annotated transcripts and 7 annotated polypeptides. Protein features are: Small GTP-binding protein domain; Small GTPase superfamily; Small GTPase superfamily, Rho type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Gene sequence location is 2R:11990191..11994734.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms dendrite self-avoidance References Matsubara et al., 2011, Genes Dev. 25(18): 1982--1996 Bakal et al., 2007, Science 316(5832): 1753--1756 Yin et al., 2008, BMC Bioinformatics 9: 264
FB2012_01	References Pollarolo et al., 2011, Nat. Neurosci. 14(12): 1525--1533 Koppen et al., 2011, Proteomics 11(22): 4397--4410 Hughes et al., 2010, J. Cell Sci. 123(7): 1099--1107 Bassi et al., 2011, J. Cell Biol. 195(4): 595--603 Ball et al., 2010, Neuron 66(4): 536--549 Sequence features BKN28182 HFA07530
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 52E5-52E5   Limits computationally determined from genome sequence between P{PZ}l(2)0507005070&P{EP}CG8414EP525 and P{EP}spinEP645&P{lacW}spink09905
Experimentally Determined Cytological Location
Cytogenetic map Notes References   Cytological location reported in FBrf0080078 was in error.     52E-52E     (Magie, 1999.8.17) 52E-52E   (determined by in situ hybridisation)   (Magie et al., 1999) 52E5-52E6   (determined by in situ hybridisation)   (Spradling et al., 1999) 52E3-52E6   (determined by in situ hybridisation)   (Strutt et al., 1997) 52D-52D   (determined by in situ hybridisation)   (Sasamura, 1995) 3C-3C   (determined by in situ hybridisation)   (Hariharan et al., 1995) 52E5-52E6     (BDGP Project Members, 1994-1999) 52E2-52E9   Hybridization of Rho1 cDNA to Df(2R)KL32 and Df(2R)Jp6 confirmed that Rho1 maps to 52E. (determined by in situ hybridisation)   (Sasamura et al., 1997) 52E3-52E6   Cytological location reported in FBrf0080078 was in error. (determined by in situ hybridisation)   (Settleman and Hariharan, 1997.8.8)
Experimentally Determined Recombination Data
Location	2-
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rho1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rho1-RA FBtr0087211  NM_057750   1195   192 Rho1-RB FBtr0087212  NM_134308   2029   192 Rho1-RC FBtr0087213  NM_134309   1798   192 Rho1-RD FBtr0087214  NM_166139   1983   192 Rho1-RE FBtr0087215  NM_206129   763   192 Rho1-RF FBtr0087216  NM_206128   1972   192 Rho1-RG FBtr0087217  NM_206127   1975   192
Additional Transcript Data & Comments
Reported size (kB)	3.7, 3.1, 2.1 (northern blot); 1.3 (unknown) (Magie et al., 1999) 1.467 (longest cDNA) (Hariharan et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rho1-PA   FBpp0086353   21.7   192   7.06     NP_477098   AAM70944 Rho1-PB   FBpp0086354   21.7   192   7.06     NP_599135   AAF58066 Rho1-PC   FBpp0086355   21.7   192   7.06     NP_599136   AAM70945 Rho1-PD   FBpp0086356   21.7   192   7.06     NP_725524   AAM70946 Rho1-PE   FBpp0089128   21.7   192   7.06     NP_995851   AAS64842 Rho1-PF   FBpp0089129   21.7   192   7.06     NP_995850   AAS64843 Rho1-PG   FBpp0089130   21.7   192   7.06     NP_995849   AAS64844
Additional Polypeptide Data & Comments
Reported size (kDa)	192 (aa) (Hariharan et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Small GTPase superfamily (IPR001806) Small GTPase superfamily, Rho type (IPR003578) Small GTP-binding protein domain (IPR005225)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202784   AA391196   AA694683   AA695628   AA735703   AA802622   AA802783   AA816258   AA817053   AA949454   AA952270   AE013599 AAF58066   AE013599 AAM70944   AE013599 AAM70945   AE013599 AAM70946   AE013599 AAS64842   AE013599 AAS64843   AE013599 AAS64844   AC004248   AF177871 AAF01183   AF177872 AAF01184   AF177873 AAF01185   AF177874 AAF01186   AI135759   AI239017   AI257703   AI294261   AI389565   AI513351   AW940792   AW941520   AY119536 AAM50190   AY432013   BF495178   BG636136   BI161597   BI161598   BI162525   BI162526   BI163292   BI164637   BI165104   BI165570   BI165877   BI166028   BI169325   BI214262   BI215147   BI227920   BI231031   BI234630   BI238440   BI238583   BI239321   BI241605   BI356759   BI361565   BI361584   BI362069   BI362544   BI362780   BI366426   BI367070   BI367429   BI367510   BI368645   BI368936   BI370112   BI374913   BI376156   BI481582   BI482701   BI487064   BI564367   BI569182   BI569183   BI575188   BI576690   BI579900   BI589315   BI590559   BI604686   BI605229   BI605555   BI605882   BI606348   BI606784   BI606829   BI607872   BI609659   BI609807   BI610789   BI611133   BI614834   BI616115   BI616247   BI619407   BI621206   BI623475   BI624050   BI629139   BI629458   BI630392   BI630939   BI638865   BP548744   BP549286   BP549287   BP551502   BP551503   BP556255   BP557976   BP560112   BT010085 AAQ22554   BT030133   BT030848   CA804415   CA807762   CK657168   CO181427   CO181605   CO183371   CO183593   CO187194   CO188444   CO265494   CO267587   CO275313   CO280485   CO281822   CO283057   CO286515   CO296814   CO299865   CO300386   CO302704   CO303880   CO304272   CO308692   CO319127   CO324269   CO338075   CS026563 CAI61748   CZ466213   CZ466317   CZ466328   CZ466342   CZ466702   CZ472750   CZ475601   CZ475602   CZ475782   EC060482   EC061692   EC064343   EC065171   EC073756   EC078037   EC078530   EC084306   EC086203   EC089155   EC200810   EC202676   EC203944   EC206460   EC210707   EC211085   EC213726   EC213941   EC213986   EC218092   EC222250   EC223206   EC234397   EC234901   EC245644   EC262511   ES692256   ES696614   ES696616   EV592978   EV594078   EV594208   EV599974   L38311
UniProtKB/Swiss-Prot	P48148
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Hariharan et al., 1995) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Sasamura et al., 1997) embryonic stage -- adult stage     (Magie et al., 1999, Sasamura et al., 1997) P-stage   organism   (Magie et al., 1999) Comment:female pupal stage   organism   (Magie et al., 1999) Comment:female adult stage | female   organism   (Magie et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0014020    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0014020 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0014020 expression level Developmental Stage   Expression Level embryo 00-02hr    6130 embryo 02-04hr    11433 embryo 04-06hr    14551 embryo 06-08hr    14420 embryo 08-10hr    14984 embryo 10-12hr    15985 embryo 12-14hr    18244 embryo 14-16hr    9004 embryo 16-18hr    12340 embryo 18-20hr    8516 embryo 20-22hr    7958 embryo 22-24hr    11143 larva L1    7973 larva L2    7965 larva L3 12hr old    7477 larva L3 puffstage 1-2    9330 larva L3 puffstage 3-6    13618 larva L3 puffstage 7-9    19934 white prepupae new    19322 white prepupae 12hr    15727 white prepupae 24hr    13618 pupae 2d postWPP    11758 pupae 3d postWPP    7930 pupae 4d postWPP    5214 adult male 01day    6468 adult male 05day    6074 adult male 30day    5846 adult female 01day    5335 adult female 05day    7177 adult female 30day    7020 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6130) embryo 02-04hr  (11433) embryo 04-06hr  (14551) embryo 06-08hr  (14420) embryo 08-10hr  (14984) embryo 10-12hr  (15985) embryo 12-14hr  (18244) embryo 14-16hr  (9004) embryo 16-18hr  (12340) embryo 18-20hr  (8516) embryo 20-22hr  (7958) embryo 22-24hr  (11143) larva L1  (7973) larva L2  (7965) larva L3 12hr old  (7477) larva L3 puffstage 1-2  (9330) larva L3 puffstage 3-6  (13618) larva L3 puffstage 7-9  (19934) white prepupae new  (19322) white prepupae 12hr  (15727) white prepupae 24hr  (13618) pupae 2d postWPP  (11758) pupae 3d postWPP  (7930) pupae 4d postWPP  (5214) adult male 01day  (6468) adult male 05day  (6074) adult male 30day  (5846) adult female 01day  (5335) adult female 05day  (7177) adult female 30day  (7020) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6130) embryo 02-04hr  (11433) embryo 04-06hr  (14551) embryo 06-08hr  (14420) embryo 08-10hr  (14984) embryo 10-12hr  (15985) embryo 12-14hr  (18244) embryo 14-16hr  (9004) embryo 16-18hr  (12340) embryo 18-20hr  (8516) embryo 20-22hr  (7958) embryo 22-24hr  (11143) larva L1  (7973) larva L2  (7965) larva L3 12hr old  (7477) larva L3 puffstage 1-2  (9330) larva L3 puffstage 3-6  (13618) larva L3 puffstage 7-9  (19934) white prepupae new  (19322) white prepupae 12hr  (15727) white prepupae 24hr  (13618) pupae 2d postWPP  (11758) pupae 3d postWPP  (7930) pupae 4d postWPP  (5214) adult male 01day  (6468) adult male 05day  (6074) adult male 30day  (5846) adult female 01day  (5335) adult female 05day  (7177) adult female 30day  (7020) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6130 embryo 02-04hr  (11433) embryo 04-06hr  (14551) embryo 06-08hr  (14420) embryo 08-10hr  (14984) embryo 10-12hr  (15985) embryo 12-14hr  (18244) embryo 14-16hr    9004 embryo 16-18hr  (12340) embryo 18-20hr    8516 embryo 20-22hr    7958 embryo 22-24hr  (11143) larva L1    7973 larva L2    7965 larva L3 12hr old    7477 larva L3 puffstage 1-2    9330 larva L3 puffstage 3-6  (13618) larva L3 puffstage 7-9  (19934) white prepupae new  (19322) white prepupae 12hr  (15727) white prepupae 24hr  (13618) pupae 2d postWPP  (11758) pupae 3d postWPP    7930 pupae 4d postWPP    5214 adult male 01day    6468 adult male 05day    6074 adult male 30day    5846 adult female 01day    5335 adult female 05day    7177 adult female 30day    7020 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6130 embryo 02-04hr    11433 embryo 04-06hr    14551 embryo 06-08hr    14420 embryo 08-10hr    14984 embryo 10-12hr    15985 embryo 12-14hr    18244 embryo 14-16hr    9004 embryo 16-18hr    12340 embryo 18-20hr    8516 embryo 20-22hr    7958 embryo 22-24hr    11143 larva L1    7973 larva L2    7965 larva L3 12hr old    7477 larva L3 puffstage 1-2    9330 larva L3 puffstage 3-6    13618 larva L3 puffstage 7-9    19934 white prepupae new    19322 white prepupae 12hr    15727 white prepupae 24hr    13618 pupae 2d postWPP    11758 pupae 3d postWPP    7930 pupae 4d postWPP    5214 adult male 01day    6468 adult male 05day    6074 adult male 30day    5846 adult female 01day    5335 adult female 05day    7177 adult female 30day    7020 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0014020 expression level Developmental Stage   Expression Level embryo 00-02hr    6130 embryo 02-04hr    11433 embryo 04-06hr    14551 embryo 06-08hr    14420 embryo 08-10hr    14984 embryo 10-12hr    15985 embryo 12-14hr    18244 embryo 14-16hr    9004 embryo 16-18hr    12340 embryo 18-20hr    8516 embryo 20-22hr    7958 embryo 22-24hr    11143 larva L1    7973 larva L2    7965 larva L3 12hr old    7477 larva L3 puffstage 1-2    9330 larva L3 puffstage 3-6    13618 larva L3 puffstage 7-9    19934 white prepupae new    19322 white prepupae 12hr    15727 white prepupae 24hr    13618 pupae 2d postWPP    11758 pupae 3d postWPP    7930 pupae 4d postWPP    5214 adult male 01day    6468 adult male 05day    6074 adult male 30day    5846 adult female 01day    5335 adult female 05day    7177 adult female 30day    7020 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6130) embryo 02-04hr  (11433) embryo 04-06hr  (14551) embryo 06-08hr  (14420) embryo 08-10hr  (14984) embryo 10-12hr  (15985) embryo 12-14hr  (18244) embryo 14-16hr  (9004) embryo 16-18hr  (12340) embryo 18-20hr  (8516) embryo 20-22hr  (7958) embryo 22-24hr  (11143) larva L1  (7973) larva L2  (7965) larva L3 12hr old  (7477) larva L3 puffstage 1-2  (9330) larva L3 puffstage 3-6  (13618) larva L3 puffstage 7-9  (19934) white prepupae new  (19322) white prepupae 12hr  (15727) white prepupae 24hr  (13618) pupae 2d postWPP  (11758) pupae 3d postWPP  (7930) pupae 4d postWPP  (5214) adult male 01day  (6468) adult male 05day  (6074) adult male 30day  (5846) adult female 01day  (5335) adult female 05day  (7177) adult female 30day  (7020) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6130) embryo 02-04hr  (11433) embryo 04-06hr  (14551) embryo 06-08hr  (14420) embryo 08-10hr  (14984) embryo 10-12hr  (15985) embryo 12-14hr  (18244) embryo 14-16hr  (9004) embryo 16-18hr  (12340) embryo 18-20hr  (8516) embryo 20-22hr  (7958) embryo 22-24hr  (11143) larva L1  (7973) larva L2  (7965) larva L3 12hr old  (7477) larva L3 puffstage 1-2  (9330) larva L3 puffstage 3-6  (13618) larva L3 puffstage 7-9  (19934) white prepupae new  (19322) white prepupae 12hr  (15727) white prepupae 24hr  (13618) pupae 2d postWPP  (11758) pupae 3d postWPP  (7930) pupae 4d postWPP  (5214) adult male 01day  (6468) adult male 05day  (6074) adult male 30day  (5846) adult female 01day  (5335) adult female 05day  (7177) adult female 30day  (7020) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6130 embryo 02-04hr  11433 embryo 04-06hr  14551 embryo 06-08hr  14420 embryo 08-10hr  14984 embryo 10-12hr  15985 embryo 12-14hr  18244 embryo 14-16hr    9004 embryo 16-18hr  12340 embryo 18-20hr    8516 embryo 20-22hr    7958 embryo 22-24hr  11143 larva L1    7973 larva L2    7965 larva L3 12hr old    7477 larva L3 puffstage 1-2    9330 larva L3 puffstage 3-6  13618 larva L3 puffstage 7-9  19934 white prepupae new  19322 white prepupae 12hr  15727 white prepupae 24hr  13618 pupae 2d postWPP  11758 pupae 3d postWPP    7930 pupae 4d postWPP    5214 adult male 01day    6468 adult male 05day    6074 adult male 30day    5846 adult female 01day    5335 adult female 05day    7177 adult female 30day    7020 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6130 embryo 02-04hr    11433 embryo 04-06hr    14551 embryo 06-08hr    14420 embryo 08-10hr    14984 embryo 10-12hr    15985 embryo 12-14hr    18244 embryo 14-16hr    9004 embryo 16-18hr    12340 embryo 18-20hr    8516 embryo 20-22hr    7958 embryo 22-24hr    11143 larva L1    7973 larva L2    7965 larva L3 12hr old    7477 larva L3 puffstage 1-2    9330 larva L3 puffstage 3-6    13618 larva L3 puffstage 7-9    19934 white prepupae new    19322 white prepupae 12hr    15727 white prepupae 24hr    13618 pupae 2d postWPP    11758 pupae 3d postWPP    7930 pupae 4d postWPP    5214 adult male 01day    6468 adult male 05day    6074 adult male 30day    5846 adult female 01day    5335 adult female 05day    7177 adult female 30day    7020 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0014020    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0014020 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014020 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8416-RB;CG8416-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Rho1 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4elav.PLu Rho1N19.Scer\UAS Rho1V14.Scer\UAS lethal, with Scer\GAL4ey-OK107 Rho1V14.Scer\UAS lethal (with Df(2R)Jp8) Rho112-6 lethal (with Rho112-6) Rho1E3.10 Rho1J3.8 lethal (with Rho1E3.10) Rho112-6 lethal (with Rho1J3.8) Rho112-6 lethal | embryonic stage Rho1E3.10 Rho1k02107b lethal | embryonic stage, with Scer\GAL4en-e16E Rho1N19.Scer\UAS lethal | embryonic stage, with Scer\GAL4prd.RG1 Rho1N19.Scer\UAS lethal | embryonic stage, with Scer\GAL4repo Rho1N19.Scer\UAS lethal | embryonic stage | maternal effect | recessive Rho1rev220 lethal | embryonic stage | recessive Rho172O Rho1E3.10 Rho1Ebr233 Rho1Ebr246 Rho1J3.8 Rho1k02107b Rho1k07236 Rho1rev220 lethal | pharate adult stage, with Scer\GAL4ppl.PP Rho1GD4726 lethal | pupal stage, with Scer\GAL4pnr-MD237 Rho1GD4726 lethal | recessive Rho112-6 Rho1E3.10 Rho1J3.8 Rho1k02107b Rho1k07236 Rho1k07903 Other Phenotypes Allele cell migration defective | embryonic stage 10, with Scer\GAL4nos.UTR.T:Hsim\VP16 Rho1N19.Scer\UAS cell shape defective Rho1rev220 cell shape defective, with Scer\GAL4MtnA.PU Rho1V14.Scer\UAS cell shape defective | conditional | third instar larval stage, with Scer\GAL4ap-md544, Scer\GAL80ts.αTub84B Rho1GD4726 Rho1V14.Scer\UAS chemical resistant, with Scer\GAL4whir3 Rho1CA.Scer\UAS cytokinesis defective Rho172O Rho1dsRNA.75-821 cytokinesis defective, with Scer\GAL4neur-P72 Rho1N19.Scer\UAS cytokinesis defective, with Scer\GAL4twi.PB Rho1N19.Scer\UAS cytokinesis defective | embryonic stage | recessive Rho172O cytokinesis defective | recessive Rho172R increased cell death, with Scer\GAL4ptc-559.1 Rho1Scer\UAS.cMa mitotic cell cycle defective, with Scer\GAL4prd.RG1 Rho1N19.Scer\UAS mitotic cell cycle defective | recessive Rho172O Rho172R neuroanatomy defective, with Scer\GAL4ey-OK107 Rho1V14.E40L.Scer\UAS Rho1V14.Scer\UAS neuroanatomy defective | embryonic stage, with Scer\GAL4repo Rho1V14.Scer\UAS neuroanatomy defective | recessive | somatic clone Rho172O non-enhancer of variegation, with In(1)wm4h Rho172O non-suppressor of variegation, with In(1)wm4h Rho172O planar polarity defective Rho1V14.sev planar polarity defective, with Scer\GAL4dpp.blk1 Rho1N19.Scer\UAS planar polarity defective, with Scer\GAL4hs.2sev Rho1Scer\UAS.cMa Rho1V14.F39V.Scer\UAS Rho1V14.Scer\UAS planar polarity defective | recessive | somatic clone Rho172BH Rho172M1 planar polarity defective | somatic clone Rho172M1 Rho1N19.sev Rho1V14.sev visible Rho1GMR.PH Rho1V14.sev visible, with Scer\GAL4ppl.PP Rho1GD4726 visible | heat sensitive, with Scer\GAL4ptc-559.1, Scer\GAL80ts.αTub84B Rho1GD4726 visible | recessive Rho1k07236 wound healing defective (with Rho172O) Rho172R wound healing defective (with Rho172R) Rho172O Phenotype manifest in Allele actin cytoskeleton | blastoderm stage | germline clone Rho1L3 actin filament & embryonic/larval tracheal system, with Scer\GAL4btl.PS Rho1GD4726 actomyosin contractile ring Rho1dsRNA.75-821 adherens junction | pupal stage, with Scer\GAL4GMR.PF Rho1dsRNA.1.Scer\UAS adherens junction | somatic clone Rho172F Rho172O adherens junction | somatic clone, with Scer\GAL4Act5C.PI Rho1dsRNA.1.Scer\UAS adult abdomen | dorsal, with Scer\GAL4ppl.PP Rho1GD4726 adult cuticle | dorsal, with Scer\GAL4ppl.PP Rho1GD4726 amnioproctodeal invagination, with Scer\GAL4nos.PG Rho1N19.Scer\UAS anterior midgut primordium, with Scer\GAL4twi.PG Rho1N19.Scer\UAS blastoderm embryo | germline clone Rho1L3 Bolwig nerve, with Scer\GAL4GMR.PF Rho1V12.Scer\UAS border follicle cell, with Scer\GAL4slbo.2.6 Rho1N19.Scer\UAS Rho1V14.Scer\UAS circular visceral muscle primordium Rho11B cortical actin cytoskeleton & embryonic posterior spiracle, with Scer\GAL4ems.HRE Rho1N19.Scer\UAS cortical actin cytoskeleton & spiracular chamber (with Rho11B) Rho172R cortical actin cytoskeleton & spiracular chamber (with Rho172R) Rho11B cortical actin cytoskeleton & syncytial blastoderm embryo | maternal effect Rho1L3 denticle belt | maternal effect Rho1rev220 disc epithelium proper & dorsal mesothoracic disc, with Scer\GAL4ptc-559.1 Rho1Scer\UAS.cMa dorsal closure embryo Rho172O Rho172R Rho1rev220 dorsal closure embryo, with Scer\GAL4en-e16E Rho1N19.Scer\UAS dorsal closure embryo, with Scer\GAL4LE Rho1N19.Scer\UAS dorsal closure embryo, with Scer\GAL4pnr-MD237 Rho1N19.Scer\UAS Rho1V12.Scer\UAS dorsal closure embryo, with Scer\GAL4prd.RG1 Rho1N19.Scer\UAS dorsal trunk primordium, with Scer\GAL4btl.PS Rho1N19.Scer\UAS Rho1V14.Scer\UAS embryo Rho172O Rho172R embryonic/first instar larval cuticle Rho172O embryonic/first instar larval cuticle, with Scer\GAL4en-e16E Rho1N19.Scer\UAS embryonic/first instar larval cuticle, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 Rho1N19.Scer\UAS embryonic/first instar larval cuticle, with Scer\GAL4prd.RG1 Rho1N19.Scer\UAS embryonic/first instar larval cuticle, with Scer\GAL4twi.PG Rho1N19.Scer\UAS embryonic/first instar larval cuticle & embryonic head Rho1rev220 embryonic/first instar larval cuticle | anterior Rho1Ebr233 Rho1Ebr246 embryonic/first instar larval cuticle | anterior | dorsal Rho1E3.10 Rho1J3.8 embryonic/first instar larval cuticle | anterior | dorsal (with Df(2R)Jp8) Rho1E3.10 embryonic/first instar larval cuticle | anterior | dorsal (with Rho172O) Rho1E3.10 embryonic/first instar larval cuticle | anterior | dorsal (with Rho1E3.10) Rho172O Rho1J3.8 embryonic/first instar larval cuticle | anterior | dorsal (with Rho1J3.8) Rho1E3.10 embryonic/first instar larval cuticle | dorsal, with Scer\GAL4hs.PB Rho1N19.Scer\UAS embryonic/larval dorsal anastomosis, with Scer\GAL4btl.PS Rho1V14.Scer\UAS embryonic/larval dorsal trunk (with Rho172F) Rho172O embryonic/larval dorsal trunk (with Rho172O) Rho172F embryonic/larval hemolymph | third instar larval stage, with Scer\GAL4He.PZ Rho1V14.Scer\UAS embryonic/larval midgut primordium, with Scer\GAL4NP2432 Rho1N19.Scer\UAS embryonic/larval posterior spiracle Rho1E3.10 embryonic/larval posterior spiracle (with Rho172O) Rho1E3.10 embryonic/larval posterior spiracle (with Rho1E3.10) Rho172O embryonic/larval trachea Rho172F embryonic dorsal epidermis Rho172F Rho172O Rho172R embryonic dorsal epidermis | anterior Rho172F Rho172O Rho172R embryonic epidermis, with Scer\GAL4en-e16E Rho1N19.Scer\UAS embryonic epidermis, with Scer\GAL4prd.RG1 Rho1N19.Scer\UAS embryonic epidermis | dorsal Rho172O Rho172R embryonic epidermis | dorsal, with Scer\GAL4LE Rho1N19.Scer\UAS embryonic epidermis | dorsal | maternal effect Rho1rev220 embryonic epidermis | maternal effect Rho1rev220 embryonic head Rho172O Rho1rev220 embryonic head (with Rho172O) Rho172R embryonic head (with Rho172R) Rho172O embryonic head | maternal effect Rho1rev220 embryonic hemocyte Rho11B embryonic hemocyte, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA Rho1N19.Scer\UAS embryonic hindgut, with Scer\GAL4NP2432 Rho1N19.Scer\UAS embryonic leading edge cell Rho172O embryonic leading edge cell, with Scer\GAL4en-e16E Rho1N19.Scer\UAS Rho1V14.Scer\UAS embryonic leading edge cell, with Scer\GAL4prd.RG1 Rho1N19.Scer\UAS embryonic leading edge cell (with Rho172O) Rho172R embryonic leading edge cell (with Rho172R) Rho172O embryonic Malpighian tubule tip cell, with Scer\GAL4ct.CtB Rho1N19.Scer\UAS embryonic segment Rho1unspecified epithelial cell | pupal stage, with Scer\GAL4GMR.PF Rho1dsRNA.1.Scer\UAS extended germ band embryo Rho1Ebr233 Rho1Ebr246 extended germ band embryo, with Scer\GAL4c381 Rho1N19.Scer\UAS Rho1V12.Scer\UAS extended germ band embryo, with Scer\GAL4Kr.PM Rho1N19.Scer\UAS Rho1V12.Scer\UAS external sensory organ precursor cell, with Scer\GAL4neur-P72 Rho1N19.Scer\UAS eye Rho1GMR.PH Rho1V14.sev Rho1k07236 eye, with Scer\GAL4hs.2sev Rho1V14.E40L.Scer\UAS eye | pupal stage, with Scer\GAL4GMR.PF Rho1dsRNA.1.Scer\UAS eye disc & photoreceptor cell & axon, with Scer\GAL4GMR.PF Rho1V12.Scer\UAS eye disc & subretinal glial cell, with Scer\GAL4GMR.PF Rho1V12.Scer\UAS eye photoreceptor cell, with Scer\GAL4hs.2sev Rho1V14.E40L.Scer\UAS eye photoreceptor cell | somatic clone Rho172M1 Rho1V14.sev eye photoreceptor cell | third instar larval stage, with Scer\GAL4GMR.PF Rho1N19.Scer\UAS filopodium, with Scer\GAL4en-e16E Rho1N19.Scer\UAS Rho1V14.Scer\UAS filopodium (with Rho172O) Rho172R filopodium (with Rho172R) Rho172O filzkorper Rho11B Rho1E3.10 filzkorper, with Scer\GAL4ems.HRE Rho1N19.Scer\UAS Rho1V14.Scer\UAS germline cell | ectopic | embryonic stage | maternal effect, with Scer\GAL4nos.UTR.T:Hsim\VP16 Rho1N19.Scer\UAS Rho1V14.Scer\UAS germline cell | embryonic stage, with Scer\GAL4nos.UTR.T:Hsim\VP16 Rho1N19.Scer\UAS head Rho172F Rho172O Rho172R hub cell | somatic clone, with Scer\GAL4Act5C.PI Rho1dsRNA.1.Scer\UAS interommatidial bristle Rho1GMR.PH lamina | third instar larval stage, with Scer\GAL4GMR.PF Rho1N19.Scer\UAS lateral trunk primordium, with Scer\GAL4btl.PS Rho1V14.Scer\UAS mesectoderm, with Scer\GAL4en-e16E Rho1N19.Scer\UAS mesoderm, with Scer\GAL4twi.PG Rho1N19.Scer\UAS mitotic telophase Rho1dsRNA.75-821 mitotic telophase & spindle Rho1dsRNA.75-821 morphogenetic furrow | somatic clone Rho172M1 mushroom body, with Scer\GAL4ey-OK107 Rho1V14.Scer\UAS Rho1dsRNA.Scer\UAS mushroom body & dendrite, with Scer\GAL4Tab2-201Y Rho1V14.Scer\UAS mushroom body & dendrite | somatic clone Rho172O Rho172R mushroom body & dendrite | somatic clone, with Scer\GAL4Tab2-201Y Rho1V14.Scer\UAS mushroom body & neuron | somatic clone Rho172O Rho172R mushroom body | somatic clone Rho172O mushroom body vertical lobe, with Scer\GAL4ey-OK107 Rho1V14.E40L.Scer\UAS nurse cell ring canal | maternal effect Rho1rev220 ommatidial precursor cluster | somatic clone Rho172R ommatidium Rho1GMR.PH Rho1V14.sev ommatidium, with Scer\GAL4GMR.PF Rho1Scer\UAS.cMa ommatidium, with Scer\GAL4hs.2sev Rho1Scer\UAS.cMa Rho1V14.F39V.Scer\UAS Rho1V14.Scer\UAS ommatidium | somatic clone Rho172M1 Rho1V14.sev oocyte | maternal effect Rho1rev220 peripheral glial cell Rho1E3.10 Rho1k02107b peripheral glial cell, with Scer\GAL4repo Rho1N19.Scer\UAS Rho1V14.Scer\UAS peripheral glial cell | embryonic stage, with Scer\GAL4repo Rho1V14.Scer\UAS photoreceptor cell Rho1GMR.PH Rho1V14.sev photoreceptor cell, with Scer\GAL4GMR.PF Rho1Scer\UAS.cMa photoreceptor cell, with Scer\GAL4hs.2sev Rho1V14.F39V.Scer\UAS Rho1V14.Scer\UAS pigment cell Rho1GMR.PH posterior spiracle primordium, with Scer\GAL4ems.HRE Rho1N19.Scer\UAS Rho1V14.Scer\UAS presumptive embryonic/larval muscle system, with Scer\GAL4how-24B Rho1N19.Scer\UAS presumptive embryonic/larval tracheal system Rho172R presumptive embryonic/larval tracheal system, with Scer\GAL4btl.PS Rho1V14.Scer\UAS presumptive embryonic salivary gland Rho11B Rho1k02107b presumptive embryonic salivary gland, with Scer\GAL4en-e16E Rho1N19.Scer\UAS presumptive embryonic salivary gland, with Scer\GAL4fkh.PH Rho1N19.Scer\UAS Rho1V12.Scer\UAS presumptive embryonic salivary gland, with Scer\GAL4twi.PB Rho1N19.Scer\UAS presumptive embryonic salivary gland (with Df(2R)Jp1) Rho1k02107b primordium of embryonic/larval spiracle, with Scer\GAL4ems.HRE Rho1N19.Scer\UAS Rho1V14.Scer\UAS retina Rho1GMR.PH rhabdomere Rho1GMR.PH RP3 neuron Rho1rev220 secondary pigment cell Rho1GMR.PH sensory neuron & axon, with Scer\GAL4repo Rho1V14.Scer\UAS stomodeal invagination, with Scer\GAL4nos.PG Rho1N19.Scer\UAS tertiary pigment cell Rho1GMR.PH tracheal primordium Rho172R ventral furrow, with Scer\GAL4nos.PG Rho1N19.Scer\UAS ventral longitudinal muscle, with Scer\GAL4how-24B Rho1N19.Scer\UAS wing | heat sensitive, with Scer\GAL4ptc-559.1, Scer\GAL80ts.αTub84B Rho1N19.Scer\UAS Rho1V14.Scer\UAS Rho1GD4726 wing | somatic clone Rho1unspecified wing | somatic clone, with Scer\GAL4Act.PU Rho1N19.Scer\UAS Rho1V14.Scer\UAS wing disc, with Scer\GAL4Bx-MS1096 Rho1Scer\UAS.cMa wing disc, with Scer\GAL4ptc-559.1 Rho1Scer\UAS.cMa wing disc | conditional | third instar larval stage, with Scer\GAL4ap-md544, Scer\GAL80ts.αTub84B Rho1V14.Scer\UAS Rho1GD4726 wing hair, with Scer\GAL4dpp.blk1 Rho1N19.Scer\UAS wing hair | heat sensitive, with Scer\GAL4ptc-559.1, Scer\GAL80ts.αTub84B Rho1N19.Scer\UAS Rho1GD4726 wing hair | somatic clone Rho172BH wing hair | somatic clone | supernumerary Rho1unspecified wing hair | somatic clone | supernumerary, with Scer\GAL4Act.PU Rho1V14.Scer\UAS wing hair | supernumerary | heat sensitive, with Scer\GAL4ptc-559.1, Scer\GAL80ts.αTub84B Rho1N19.Scer\UAS Rho1V14.Scer\UAS Rho1GD4726
Classical Alleles ( 34 )
For All Classical Alleles Show
Allele of Rho1 Class Mutagen Stocks Known lesion Rho1E3.10 loss of function allele 2 Yes Rho1KG01774 2 -- Rho11B loss of function allele P-element activity 1 Yes Rho172F P-element activity 1 Yes Rho172O P-element activity 1 Yes Rho1c00122 piggyBac transposase 1 -- Rho1c00252 piggyBac transposase 1 -- Rho1CB-6645-3 1 -- Rho1d02325 P-element activity 1 -- Rho1k02107b P-element activity 1 Yes Rho1NP0324 1 -- Rho112-6 ethyl methanesulfonate 0 -- Rho172BH hypomorphic allele - genetic evidence P-element activity 0 Yes Rho172M1 hypomorphic allele - genetic evidence P-element activity 0 Yes Rho172R loss of function allele, hypomorphic allele - genetic evidence P-element activity 0 Yes Rho179-3 0 -- Rho1BH 0 -- Rho1c00263 piggyBac transposase 0 -- Rho1c00282 piggyBac transposase 0 -- Rho1c00763 piggyBac transposase 0 -- Rho1d07224 P-element activity 0 -- Rho1d07511 P-element activity 0 -- Rho1Df236 0 -- Rho1Df903 0 -- Rho1E.10 0 -- Rho1Ebr233 ethyl methanesulfonate 0 -- Rho1Ebr246 ethyl methanesulfonate 0 -- Rho1J3.8 0 Yes Rho1k02107rev5 P-element activity 0 Yes Rho1k07236 P-element activity 0 Yes Rho1k07903 P-element activity 0 Yes Rho1L3 P-element activity 0 Yes Rho1rev220 0 Yes Rho1unspecified 0 --
Alleles Carried on Transgenic Constructs ( 34 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rho1 Class Mutagen Stocks Known lesion Rho1T:Avic\GFP in vitro construct - coding region fusion 3 Yes Rho1dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 2 Yes Rho1N19.Scer\UAS in vitro construct - regulatory fusion 2 Yes Rho1Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes Rho1Scer\UAS.P\T.T:Uuuu\T7 in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes Rho1V14.E40L.Scer\UAS in vitro construct - amino acid replacement in vitro construct - regulatory fusion 2 Yes Rho1V14.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 2 Yes Rho1D100N.Scer\UAS.P\T.T:Uuuu\T7 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 1 Yes Rho1dsRNA.1.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes Rho1dsRNA.2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes Rho1GD4726 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rho1HMS00375 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rho1JF02809 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rho1Scer\UAS.cMa in vitro construct - regulatory fusion 1 Yes Rho1Scer\UAS.cWa in vitro construct - regulatory fusion 1 Yes Rho1V14.F39V.Scer\UAS in vitro construct - amino acid replacement in vitro construct - regulatory fusion 1 Yes Rho1+mMa in vitro construct - minigene 0 Yes Rho1Act5C.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Rho1CA.Scer\UAS in vitro construct - regulatory fusion 0 Yes Rho1dsRNA.75-821 in vitro construct - RNAi 0 Yes Rho1dsRNA.cCa in vitro construct - RNAi 0 Yes Rho1dsRNA.cHa in vitro construct - RNAi 0 Yes Rho1dsRNA.cMa in vitro construct - RNAi 0 Yes Rho1dsRNA.cMb in vitro construct - RNAi 0 Yes Rho1dsRNA.cRa in vitro construct - RNAi 0 Yes Rho1dsRNA.cSa in vitro construct - RNAi 0 Yes Rho1GMR.PH in vitro construct - minigene in vitro construct - regulatory fusion 0 Yes Rho1KK108182 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Rho1N19.sev in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 -- Rho1Scer\UAS.cHa in vitro construct - regulatory fusion 0 Yes Rho1Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Rho1Scer\UAS:T:Avic\GFP-CFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Rho1V12.Scer\UAS in vitro construct - regulatory fusion 0 Yes Rho1V14.sev in vitro construct - regulatory fusion 0 --
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7139 (Ryder, 2004.4.26) Df(2R)Jp4 (Halsell et al., 2000) Df(2R)Jp6 (BDGP Project Members, 1994-1999, Sasamura et al., 1997, Rothenfluh et al., 2006) Df(2R)Jp8 (Halsell and Kiehart, 1998, Prokopenko et al., 1999, Halsell et al., 2000, Ward et al., 2003, Bayer et al., 2003, BDGP Project Members, 1994-1999) Df(2R)Np3 (BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)44CE (BDGP Project Members, 1994-1999) Df(2R)Dg248 (Mirouse et al., 2009, Mirouse et al., 2009) Df(2R)Dg323 (Mirouse et al., 2009, Mirouse et al., 2009) Df(2R)Jp1 (Spradling et al., 1999, Halsell et al., 2000, BDGP Project Members, 1994-1999) Df(2R)KL32 (BDGP Project Members, 1994-1999, Sasamura et al., 1997) Df(2R)WMG (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4726} NA P{KK108182} NA P{TRiP.HMS00375} NA P{TRiP.JF02809} NA P{UAS-Rho1.325-786.dsRNA} NA P{UAS-Rho1.770-1310.dsRNA} NA P{UAS-Rho1.CA} NA P{UAS-Rho1.CFP} NA P{UAS-Rho1.G14V} NA P{UAS-Rho1.GFP} NA P{UAS-Rho1.L} NA P{UAS-Rho1.N19} NA P{UAS-Rho1.Sph} NA P{UAS-Rho1.V12} NA P{UAS-Rho1.V14.E40L} NA P{UAS-Rho1.V14.F39V} NA P{UAS-Rho1.V14} NA P{UAS-Rho1.W} NA P{UAS-Rho1-dsRNA} NA heat-shock construct P{sE-Rho1.V14} NA characterization construct P{GMR-Rho1} NA P{Rho1+mMa} NA P{sE-Rho1.N19} NA P{UAS-Rho1.EGFP} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH0145SH0145 No P{lacW}Rho1k02107b No P{lacW}Rho1k07236 No P{lacW}Rho1k07903 No insertion of enhancer trap binary system P{GawB}Rho1NP0324 No PBac{GAL4D,EYFP}Rho1L3 No miscellaneous insertions P{RS3}Rho1CB-6645-3 NA P{SUPor-P}Rho1KG01774 NA P{wHy}Syn2DG09306 NA PBac{PB}Rho1c00122 NA PBac{PB}Rho1c00252 NA PBac{PB}Rho1c00263 NA PBac{PB}Rho1c00282 NA PBac{PB}Rho1c00763 NA insertion of mobile activating element P{GSV1}GSd231GSd231 NA P{GSV1}GSd431GSd431 NA P{XP}Rho1d02325 NA P{XP}Rho1d07224 NA P{XP}Rho1d07511 NA
Gene Ontology: Function, Process & Cellular Component ( 63 unique terms )
Terms Based on Experimental Evidence ( 48 terms )
Molecular Function
CV term Evidence References
kinase binding inferred from physical interaction with rok (Winter et al., 2001) protein binding inferred from physical interaction with rok (Mizuno et al., 1999) inferred from physical interaction with wash (Liu et al., 2009)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from mutant phenotype (Padash Barmchi et al., 2005) actin filament bundle assembly inferred from mutant phenotype (Wood et al., 2002) actin filament organization inferred from mutant phenotype (Kiger et al., 2003, Yan et al., 2009) axon guidance inferred from mutant phenotype (Fritz and VanBerkum, 2002) border follicle cell migration inferred from mutant phenotype (Bastock and Strutt, 2007) cell elongation involved in imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Widmann and Dahmann, 2009) cellularization inferred from mutant phenotype (Padash Barmchi et al., 2005) compound eye morphogenesis inferred from genetic interaction with p120ctn (Larson et al., 2008) cytokinesis inferred from mutant phenotype (Somma et al., 2002, Kiger et al., 2003, Echard et al., 2004, Eggert et al., 2004, Dean et al., 2005) dendrite self-avoidance inferred from genetic interaction with stan (Matsubara et al., 2011) determination of left/right symmetry inferred from mutant phenotype (Taniguchi et al., 2007) dorsal closure inferred from mutant phenotype (Bloor and Kiehart, 2002) NOT dorsal closure, amnioserosa morphology change inferred from mutant phenotype (Harden et al., 2002) dorsal closure, leading edge cell differentiation inferred from mutant phenotype (Jacinto et al., 2002) dorsal closure, spreading of leading edge cells inferred from mutant phenotype (Jacinto et al., 2002) endocytosis inferred from mutant phenotype (Magie and Parkhurst, 2005) epidermal growth factor receptor signaling pathway inferred from genetic interaction with cv-c (Brodu and Casanova, 2006) establishment of protein localization inferred from mutant phenotype (Dean et al., 2005) gastrulation involving germ band extension inferred from mutant phenotype (Barrett et al., 1997) germ-band extension inferred from mutant phenotype (Barrett et al., 1997) glial cell migration inferred from mutant phenotype (Sepp and Auld, 2003) hemocyte migration inferred from mutant phenotype (Stramer et al., 2005) imaginal disc-derived wing hair organization inferred from genetic interaction with fz (Winter et al., 2001) inferred from mutant phenotype (Yan et al., 2009) lumen formation, open tracheal system inferred from mutant phenotype (Lee and Kolodziej, 2002) maintenance of epithelial cell apical/basal polarity inferred from mutant phenotype (Xu et al., 2008) melanization defense response inferred from mutant phenotype (Bidla et al., 2007) NOT muscle attachment inferred from mutant phenotype (Bloor and Kiehart, 2001) NOT myofibril assembly inferred from mutant phenotype (Bloor and Kiehart, 2001) neuroblast proliferation inferred from mutant phenotype (Lee et al., 2000) open tracheal system development inferred from mutant phenotype (Matusek et al., 2006, Lovegrove et al., 2006) peripheral nervous system development inferred from mutant phenotype (Sepp and Auld, 2003, Sepp and Auld, 2003) posterior midgut invagination inferred from mutant phenotype (Barrett et al., 1997) pseudocleavage involved in syncytial blastoderm formation inferred from mutant phenotype (Webb et al., 2009) regulation of axonogenesis inferred from genetic interaction with LIMK1 (Ng and Luo, 2004) regulation of cytoskeleton organization inferred from direct assay (Liu et al., 2009) regulation of embryonic cell shape inferred from mutant phenotype (Xu et al., 2008) regulation of Malpighian tubule size inferred from mutant phenotype (Denholm et al., 2005) regulation of tube length, open tracheal system inferred from mutant phenotype (Chung et al., 2009) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009) salivary gland morphogenesis inferred from mutant phenotype (Xu et al., 2008) spiracle morphogenesis, open tracheal system inferred from mutant phenotype (Simoes et al., 2006) ventral furrow formation inferred from mutant phenotype (Barrett et al., 1997) wound healing inferred from mutant phenotype (Wood et al., 2002)
Cellular Component
CV term Evidence References
cell cortex inferred from direct assay (Rosales-Nieves et al., 2006) cell hair inferred from direct assay (Yan et al., 2009) cytoplasm inferred from direct assay (Yan et al., 2009)
Terms Based on Predictions or Assertions ( 19 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from sequence or structural similarity (Jekely, 2003) inferred from sequence or structural similarity with EMBL:AF014371 (FlyBase, 1992-) non-traceable author statement (Noselli and Agnes, 1999, Swiss-Prot Project Members, 1996.2.1) traceable author statement (Newsome et al., 2000) GTP binding inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR003578, InterPro:IPR005225 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
actin cytoskeleton organization traceable author statement (Johnstone and Lasko, 2001) branch fusion, open tracheal system traceable author statement (Starz-Gaiano and Montell, 2004) cellularization traceable author statement (Mazumdar and Mazumdar, 2002) cytoskeleton organization traceable author statement (Van Aelst and Symons, 2002) dendrite morphogenesis traceable author statement (Gao and Bogert, 2003) dorsal closure traceable author statement (Noselli and Agnes, 1999, Van Aelst and Symons, 2002, Harden, 2002) establishment of imaginal disc-derived wing hair orientation traceable author statement (Noselli and Agnes, 1999) establishment of planar polarity non-traceable author statement (Mlodzik, 2002) traceable author statement (Tree et al., 2002) establishment of tissue polarity non-traceable author statement (Van Aelst and Symons, 2002) gastrulation non-traceable author statement (Leptin, 1999) germ cell migration traceable author statement (Starz-Gaiano and Montell, 2004) JNK cascade non-traceable author statement (Noselli and Agnes, 1999) lumen formation, open tracheal system traceable author statement (Ghabrial et al., 2003) motor axon guidance non-traceable author statement (Patel and Van Vactor, 2002) ommatidial rotation non-traceable author statement (Van Aelst and Symons, 2002) traceable author statement (Noselli and Agnes, 1999) small GTPase mediated signal transduction inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR003578 (FlyBase Curators et al., 2004-) Wnt receptor signaling pathway non-traceable author statement (Wedlich, 2002)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rho1 allele Gene References Rho112-6 E(zip)12-5 (Bayer et al., 2003) E(zip)18-5 (Bayer et al., 2003) E(zip)31-6 (Bayer et al., 2003) RhoGEF2 (Bayer et al., 2003) rok (Bayer et al., 2003) Sb (Bayer et al., 2003) zip (Bayer et al., 2003) Rho172BH zip (Mizuno et al., 2002) Rho172F Sb (Bayer et al., 2003) zip (Halsell et al., 2000) Rho172O br (Chen et al., 2004) CycE (Brumby et al., 2004) fz (Winter et al., 2001) LIMK1 (Chen et al., 2004, Ng and Luo, 2004) Pak (Ng and Luo, 2004) pbl (Echard and O'Farrell, 2003) Rac1 (Tan et al., 2003) Sb (Bayer et al., 2003, Chen et al., 2004) ssh (Ng and Luo, 2004) zip (Halsell et al., 2000, Mizuno et al., 2002) Rho172R btl (Zhu et al., 2005) CycE (Brumby et al., 2004) LIMK1 (Ng and Luo, 2004) Moe (Speck et al., 2003) pbl (Prokopenko et al., 1999, Shandala et al., 2004) Pkn (Lu and Settleman, 1999) Rac1 (Fanto et al., 2000) Rho1dsRNA.cRa RhoGEF2 (Rogers et al., 2004) Rho1E3.10 br (Ward et al., 2003, Bayer et al., 2003) E(br)24 (Ward et al., 2003) E(br)121 (Ward et al., 2003) E(zip)12-5 (Bayer et al., 2003) E(zip)18-5 (Bayer et al., 2003) E(zip)31-6 (Bayer et al., 2003) flw (Vereshchagina et al., 2004) Moe (Speck et al., 2003) RhoGEF2 (Bayer et al., 2003) rok (Bayer et al., 2003) Sb (Bayer et al., 2003) zip (Halsell and Kiehart, 1998, Halsell et al., 2000, Bayer et al., 2003) Rho1Ebr233 br (Ward et al., 2003) RhoGEF2 (Ward et al., 2003) zip (Ward et al., 2003) Rho1Ebr246 br (Ward et al., 2003) RhoGEF2 (Ward et al., 2003) zip (Ward et al., 2003) Rho1GMR.PH Cdc37 (Hariharan et al., 1995) dia (Prokopenko et al., 1999) Parp (Uchida et al., 2002) pbl (Prokopenko et al., 1999) RhoGEF2 (Barrett et al., 1997) Rho1J3.8 br (Ward et al., 2003, Bayer et al., 2003) E(br)65 (Ward et al., 2003) E(br)121 (Ward et al., 2003) E(br)155 (Ward et al., 2003) E(br)420 (Ward et al., 2003) E(br)444 (Ward et al., 2003) E(zip)12-5 (Bayer et al., 2003) E(zip)18-5 (Bayer et al., 2003) E(zip)31-6 (Bayer et al., 2003) peb (Wilk et al., 2004) RhoGEF2 (Bayer et al., 2003) rok (Bayer et al., 2003) Sb (Ward et al., 2003, Bayer et al., 2003) zip (Halsell and Kiehart, 1998, Halsell et al., 2000, Bayer et al., 2003) Rho1k02107b br (Ward et al., 2003, Chen et al., 2004) E(br)121 (Ward et al., 2003) E(br)444 (Ward et al., 2003) LIMK1 (Chen et al., 2004) Sb (Chen et al., 2004) Rho1k07236 plexB (Hu et al., 2001) Rho1k07903 dsh (Boutros et al., 1998) Rac1 (Fanto et al., 2000) Rho1N19.Scer\UAS BacA\p35 (Bloor and Kiehart, 2002) Gef64C (Bashaw et al., 2001) robo (Fritz and VanBerkum, 2002) Sos (Fritz and VanBerkum, 2002) Rho1rev220 capu (Magie et al., 1999) cta (Magie et al., 1999) plexB (Hu et al., 2001) Rho1Scer\UAS.cMa LIMK1 (Ng and Luo, 2004) RhoGAPp190 (Billuart et al., 2001) rin (Pazman et al., 2000) Rho1V14.Scer\UAS robo (Fritz and VanBerkum, 2002) Sos (Fritz and VanBerkum, 2002) Rho1V14.sev dsh (Boutros et al., 1998) rin (Pazman et al., 2000) unspecified cv-c (Brodu and Casanova, 2006, Denholm et al., 2005) DAAM (Matusek et al., 2006) dsh (Strutt et al., 1997) fz (Strutt et al., 1997) Gef64C (Simoes et al., 2006) grim (Mueller et al., 2005) H (Mueller et al., 2005) Moe (Molnar and de Celis, 2006) p53 (Mueller et al., 2005) rpr (Mueller et al., 2005) shg (Mirkovic and Mlodzik, 2006) tow (Chung et al., 2007) W (Mueller et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62500 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0014020 DroID - A comprehensive database of gene and protein interactions. • FBgn0014020 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36775
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11290 Dere\GG20566 Dgri\GH22067 Dmoj\GI19151 Dper\GL20555 Dpse\GA25121 Dsec\GM21657 Dsim\GD11158 Dvir\GJ22286 Dwil\GK23137 Dyak\GE11751
Curated drosophilid orthologs	Dpse\GA21061   Hsap\ARHA (Sepp and Auld, 2003)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013139-PD Aedes aegypti (mosquito) AGAP005160-PA Anopheles gambiae (mosquito) XP_393401.1 Apis mellifera (honey bee) XP_001947407.1 Acyrthosiphon pisum (pea aphid) 16310 Batrachochytrium dendrobatidis (chytrid fungus) 115215 Branchiostoma floridae (lancelet) XP_001896907.1 Brugia malayi (roundworm nematode) ENSBTAP00000005600 Bos taurus (bovine) CAL0005137 Candida albicans (a form of yeast) CN14522 Caenorhabditis brenneri (small nematode) CBP09433 Caenorhabditis briggsae (nematode) CE25369 Caenorhabditis elegans (worm) ENSCAFP00000030436 Canis familiaris (dog) CAGL0I08459g Candida glabrata (haploid yeast) ENSCINP00000006386 Ciona intestinalis (sea squirt) JA04536 Caenorhabditis japonica (nematode) cn07215 Cryptococcus neoformans (yeast-like fungus) ENSCPOP00000012676 Cavia porcellus (guinea pig) RP19744 Caenorhabditis remanei (nematode) ENSCSAVP00000011798 Ciona savignyi (sedentary tunicate) 176229 Capitella spl (polychaete worm) DEHA2B11550g Debaryomyces Hansenii (yeast) 301996 Daphnia pulex (daphnia) ENSDARP00000040644 Danio rerio (zebra fish) ENSDARP00000042416 Danio rerio (zebra fish) ENSECAP00000008136 Equus caballus (horse) ENSGACP00000012671 Gymnopilus aculeatus (mushroom) ENSGALP00000033584 Gallus gallus (chicken) ENSGALP00000039370 Gallus gallus (chicken) 67950 Hypsipyla robusta (cedar shoot borer) ENSP00000265538 Homo sapiens (human) ISCW016777-PA Ixodes scapularis (deer tick) KLLA0B10626g Kluyveromyces lactis (yeast) 233776 Lottia gigantea (owl limpet) 24474 Monocosta brevicollis (choanoflagellate) ENSMODP00000036133 Monodelphis domestica (gray opossum) ENSMMUP00000017010 Macaca mulatta (rhesus monkey) ENSMUSP00000007959 Mus musculus (house mouse) 243859 Nematostella vectensis (starlet anemone) XP_001607487.1 Nasonia vitripennis (wasp) ENSOANP00000021775 Ornithorynchus anatinus (platypus) ENSORLP00000023403 Oryzias latipes (japanese killifish) PHUM001012-PA Pediculus humanus (human body louse) ENSPPYP00000011947 Pongo pygmaeus (orangutan) ENSPTRP00000025759 Pan troglodytes (chimpanzee) ENSRNOP00000017254 Rattus norvegicus (norway rat) YPR165W Saccharomyces cerevisiae (budding yeast) Smp_072140 Schistosoma mansoni (trematode parasite) SPAC1F7.04 Schizosaccharomyces pombe (fission yeast) XP_001178170.1 Strongylocentrotus purpuratus (purple sea urchin) 20369 Trichoplax adhaerens (metazoa) XP_974483.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018092 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000046795 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000015090 Xenopus tropicalis (frog) YALI0D01045g Yarrowia lipolytica (nonconventional yeast) YALI0E23001g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12244 LH21923 ISCW016777 FBgn0229545 FBgn0225099 FBgn0209399 FBgn0182913 FBgn0176537 JGI_V11_301996 FBgn0246504 FBgn0158150 FBgn0141890 FBgn0129528 FBgn0112756 FBgn0088330 ACYPI003261 ACYPI001372 GB13135 AGAP005160 AAEL013139 PB19884 PHUM309390 GLEAN_09158
Stocks & Reagents
Stocks Listed in FlyBase ( 37 )
Bloomington	28872 w*; P{UAS-Rho1.W}3 9527 P{GFP-Rho1}11, w1118 9528 w1118; P{GFP-Rho1}21 24762 w1118; P{GFP-Rho1}30 9392 P{UASp-GFP.Rho1}1, w* 7327 P{UAS-Rho1.N19}1.3, w* 7328 w*; P{UAS-Rho1.N19}2.1 7334 w*; P{UAS-Rho1.Sph}2.1 8144 w*; P{UAS-Rho1.V14}2.1
Harvard	- P{XP}Rho1d02325 - PBac{PB}Rho1c00122 - PBac{PB}Rho1c00252
	More stocks available...
Genomic Clones ( 2 )
	BACR04O19 BACR29I14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 148 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH20776 LD03419
Other clones	DPiM_GH20776 IP16828 IP16928
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04036 GH13626 GH15180 GH26530 GM01272 GM03149 GM06023 GM06308 GM09580 LD01073 LD09296 LD22066 LD29382 LD29467 LP06151 LP07589 LP23255 RE02650 RE04349 RE04920 RE05490 RE05866 RE06047 RE10465 RE17915 RE20016 RE21373 RE25311 RE30363 RE34911 RE35073 RE35782 RE38720 RE42962 RE45837 RE45866 RE46532 RE47135 RE47438 RE51960 RE52744 RE53193 RE53286 RE54651 RE54996 RE56517 RE62606 RE64089 RE64158 RE65427 RE70569 RE74006 RH04195 RH11842 RH14469 RH14641 RH16596 RH17262 RH28476 RH31720 RH33295 RH37261 RH44314 RH45963 RH46144 RH50439 RH52515 RH55740 RH56436 RH57956 RH58332 RH59427 RH60284 RH70132 RH70778 RH71310 RH71885 RH72687 RH73616 RH73664 SD13734 SD21262
Other clones	10936 32959 38121 40355 40420 50682 51125 53994 58435 61141 65284 65708 81667 103485 106174 106866 156403 159893 162433 175707 569925 CK01.31A.G6 CK01.50A.D8 Dmel_neb_014064_0698_1910 Dmel_neb_014781_0671_1415 Dmel_neb_015084_0637_2589 Dmel_neb_016117_0956_0694 EC14287 EC14729 EC25604 EC26006 EK026959 EK040221 EK063034 EK117106 EK142813 EK150935 EK154159 EK158861 EK162134 EK176759 EK178062 EK184737 EK193110 EK215221 EK243043 EK244238 EK259127 EK276334 EN15913 ESG019c.E21_A04 ESG0113c.B21.1_B03 FGM001E10 FGM004F11 FGM213C02 FGM302D02 FGM312C07 FGM324G03 RE01068 RE01816 RH01339
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0014020 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36775
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Rho1 l(2)52Fa (Halsell et al., 2000) Source for merge of: Rho1 l(2)k02107b (Magie et al., 1999)
Additional comments
Other Comments
	Rho1 is an upstream regulator of DAAM. (Matusek et al., 2006) The active Rho1 product promotes microtubule/microfilament crosslinking by sequestering the spir-PD isoform, preventing this protein from binding to spir-PC and capu. (Rosales-Nieves et al., 2006) Rho1 regulates shg but not arm localisation and the effect of loss of Rho1 is not enhanced or suppressed by removing p120ctn. (Fox et al., 2005) trc (He et al., 2005) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes no cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells. (Echard et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells. (Eggert et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells with increased or polarized (uneven) accumulation of F-actin. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Rho1 and Rac1 mediate the dynamic rearrangement of actin in peripheral glia. (Sepp and Auld, 2003) Rho1 appears to be required for the regulation of actin polymerisation and/or myosin activity that is critical for thr response of growth cones to midline repulsive signals. (Fritz and VanBerkum, 2002) Rho1 is necessary for normal morphology and behaviour of the leading edge cells during embryonic dorsal closure. (Jacinto et al., 2002) Rho1 is necessary for actin cable formation, but not cellular extenion formation during wound healing in the embryo. (Wood et al., 2002) Rho1 is required for neuroblast proliferation but not for neuronal survival in the mushroom body. (Lee et al., 2000) Together with Pkn, Rho1 mediates a pathway for cell shape changes in dorsal closure that is independent of the Rac GTPase-mediated Jun amino (N)-terminal kinase (JNK) cascade. (Lu and Settleman, 1999) Rho1 is required for many early events, both maternally and zygotically. Rho1 does not interact with members of the JNK signalling pathway. (Magie et al., 1999) pbl is linked through Rho1 activity to the reorganisation of the actin cytoskeleton. (Prokopenko et al., 1999) Rho1 is required for invagination of mesodermal and endodermal primordia during gastrulation and its activation is likely to be regulated by RhoGEF2. (Hacker and Perrimon, 1998) Complements S.cerevisiae RHO1 mutation. (Sasamura et al., 1997) Rho1 has been cloned and sequenced. Rho1 is required for the generation of tissue polarity. Genetic interactions indicate that Rho1 has a role in signalling mediated by fz and dsh. (Strutt et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057750 NM_134308 NM_134309 NM_166139 NM_206127 NM_206128 NM_206129 RefSeq (Proteins) • NP_477098 NP_599135 NP_599136 NP_725524 NP_995849 NP_995850 NP_995851 DDBJ / EMBL / GenBank • AA202784 AAA67042 AAF01183 AAF01184 AAF01185 AAF01186 AAF58066 AAM50190 AAM70944 AAM70945 AAM70946 AAQ22554 AAS64842 AAS64843 AAS64844 AC004248 AF177871 AF177872 AF177873 AF177874 AI389565 AW940792 AW941520 AY119536 BT010085 CAI61748 CS026563 CZ466213 CZ466317 CZ466328 CZ466342 CZ466702 CZ472750 CZ475601 CZ475602 CZ475782 L38311 Entrez Gene - A searchable database of RefSeq genes. • 36775 UniProtKB/Swiss-Prot • P48148
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Small GTPase superfamily (IPR001806) Small GTPase superfamily, Rho type (IPR003578) Small GTP-binding protein domain (IPR005225)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62500 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0014020 DroID - A comprehensive database of gene and protein interactions. • FBgn0014020 DRSC - Results from RNAi screens. • FBgn0014020 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014020 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8416-RB;CG8416-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0014020 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 99990 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36775 InParanoid A subset of ortholog calls from InParanoid. • AAEL013139-PD Aedes aegypti (mosquito) AGAP005160-PA Anopheles gambiae (mosquito) XP_393401.1 Apis mellifera (honey bee) XP_001947407.1 Acyrthosiphon pisum (pea aphid) 16310 Batrachochytrium dendrobatidis (chytrid fungus) 115215 Branchiostoma floridae (lancelet) XP_001896907.1 Brugia malayi (roundworm nematode) ENSBTAP00000005600 Bos taurus (bovine) CAL0005137 Candida albicans (a form of yeast) CN14522 Caenorhabditis brenneri (small nematode) CBP09433 Caenorhabditis briggsae (nematode) CE25369 Caenorhabditis elegans (worm) ENSCAFP00000030436 Canis familiaris (dog) CAGL0I08459g Candida glabrata (haploid yeast) ENSCINP00000006386 Ciona intestinalis (sea squirt) JA04536 Caenorhabditis japonica (nematode) cn07215 Cryptococcus neoformans (yeast-like fungus) ENSCPOP00000012676 Cavia porcellus (guinea pig) RP19744 Caenorhabditis remanei (nematode) ENSCSAVP00000011798 Ciona savignyi (sedentary tunicate) 176229 Capitella spl (polychaete worm) DEHA2B11550g Debaryomyces Hansenii (yeast) 301996 Daphnia pulex (daphnia) ENSDARP00000040644 Danio rerio (zebra fish) ENSDARP00000042416 Danio rerio (zebra fish) ENSECAP00000008136 Equus caballus (horse) ENSGACP00000012671 Gymnopilus aculeatus (mushroom) ENSGALP00000033584 Gallus gallus (chicken) ENSGALP00000039370 Gallus gallus (chicken) 67950 Hypsipyla robusta (cedar shoot borer) ENSP00000265538 Homo sapiens (human) ISCW016777-PA Ixodes scapularis (deer tick) KLLA0B10626g Kluyveromyces lactis (yeast) 233776 Lottia gigantea (owl limpet) 24474 Monocosta brevicollis (choanoflagellate) ENSMODP00000036133 Monodelphis domestica (gray opossum) ENSMMUP00000017010 Macaca mulatta (rhesus monkey) ENSMUSP00000007959 Mus musculus (house mouse) 243859 Nematostella vectensis (starlet anemone) XP_001607487.1 Nasonia vitripennis (wasp) ENSOANP00000021775 Ornithorynchus anatinus (platypus) ENSORLP00000023403 Oryzias latipes (japanese killifish) PHUM001012-PA Pediculus humanus (human body louse) ENSPPYP00000011947 Pongo pygmaeus (orangutan) ENSPTRP00000025759 Pan troglodytes (chimpanzee) ENSRNOP00000017254 Rattus norvegicus (norway rat) YPR165W Saccharomyces cerevisiae (budding yeast) Smp_072140 Schistosoma mansoni (trematode parasite) SPAC1F7.04 Schizosaccharomyces pombe (fission yeast) XP_001178170.1 Strongylocentrotus purpuratus (purple sea urchin) 20369 Trichoplax adhaerens (metazoa) XP_974483.1 Tribolium castaneum (red flour beetle) ENSTNIP00000018092 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000046795 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000015090 Xenopus tropicalis (frog) YALI0D01045g Yarrowia lipolytica (nonconventional yeast) YALI0E23001g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/rho1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36775 modMine - Data generated by the modENCODE project. • FBgn0014020 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12244 LH21923 ISCW016777 FBgn0229545 FBgn0225099 FBgn0209399 FBgn0182913 FBgn0176537 JGI_V11_301996 FBgn0246504 FBgn0158150 FBgn0141890 FBgn0129528 FBgn0112756 FBgn0088330 ACYPI003261 ACYPI001372 GB13135 AGAP005160 AAEL013139 PB19884 PHUM309390 GLEAN_09158
Synonyms & Secondary IDs ( 32 )
Reported As
Symbol Synonym	8416 (Ravi et al., 2009) AAF01186 (Jekely, 2003) CG8416 (Rogers et al., 2003, Quinones-Coello, 2007, Perkins et al., 2009, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Cammarato et al., 2011) Dm Rho1 (Jekely, 2003) DmRHO-A (Mentzel and Raabe, 2005) dnRho (Fritz and VanBerkum, 2002) DRho (Noselli, 2002) DRho1 (Lawrence and Morel, 2003, Chen et al., 2002, Mizuno et al., 2002, Stronach and Perrimon, 1999) Drho1 (Raymond et al., 2001, Mizuno et al., 1999) dRho1 (Magie and Parkhurst, 2001) D-Rho1 (Ryabinina et al., 2006) dRhoA (Das et al., 2002) DrhoA (Greco et al., 2001, Noselli and Agnes, 1999, Agnes and Noselli, 1999, Noselli, 1998, Sasamura et al., 1997, Sasamura et al., 1995) DRhoA (Bateman and Van Vactor, 2001, Hacker et al., 1998, Hacker and Perrimon, 1998) E3.10/J3.8 (Halsell and Kiehart, 1998) l(2)52Fa   l(2)k02107b (BDGP Project Members, 1994-1999, ) n(2)k07236 (Spradling, 1999.12.9) Rho (McClatchey and Giovannini, 2005, Grzeschik and Knust, 2005, D'Avino et al., 2004, Fan et al., 2003, Bejsovec, 2005, Manning et al., 2002, Talbot and VanBerkum, 2005, Stewart and Ward, 2005, Rosales-Nieves et al., 2005, Jefferson et al., 2004, Stramer et al., 2004, Keung et al., 2004, Fox et al., 2004, Finn and Fehon, 2004, Avet-Rochex et al., 2004, Jekely, 2003, Bashaw et al., 2001, Shilo, 2003, Baum, 2002, Jacinto et al., 2001, Bokel and Brown, 2002, Etienne-Manneville and Hall, 2002, Speck et al., 2003, Matani et al., 2003, Park et al., 2002, Strutt et al., 2002, Fritz and Vanberkum, 2001, Fritz and VanBerkum, 2001, Bashaw et al., 2001, Jacinto and Martin, 2001, Johnson et al., 2001, Guichard et al., 2001, Chen et al., 2001, Bee et al., 2001, Chang and Ready, 2000, Luo, 2000, Seidensticker and Behrens, 2000, Bloor and Kiehart, 2000, Chen et al., 2000, Martin-Bermudo et al., 1999, Frasch, 1999, Montell, 1999, Crawford et al., 1998, Sutherland and Witke, 1999, Magie et al., 1999, Kerber et al., 1998, Bloor and Kiehart, 1998, O'Leary et al., 1998, Meyer and Parkhurst, 1997, Meyer and Parkhurst, 1997, Xu et al., 2006, Stewart et al., 2006, Kolesnikov, 2006, Homem et al., 2006, Xu et al., 2007, Artabazon et al., 2007, Talbot and VanBerkum, 2006, Fehon, 2006, Emery et al., 2005, Stramer et al., 2005, Gregory et al., 2007, Hozumi et al., 2006, Elsaesser et al., 2010, Warren-Paquin et al., 2008, Avet-Rochex et al., 2007, Ng, 2008, Yang and Bashaw, 2006, Schotman et al., 2009, Gupta et al., 2009, Larson et al., 2008, Homem and Peifer, 2009, Uehara et al., 2010, Goldbach et al., 2010, Blanchard et al., 2010, He et al., 2010, Ball et al., 2010) RHO (Muller and Littlewood-Evans, 2001) rho (Pandur et al., 2002, Pazman and Haynes, 2000, Beitel and Krasnow, 1998, Huelsmann et al., 2006, O'Keefe et al., 2007, Brown et al., 2007) Rho1 (Sweeney et al., 2008, Aleksic et al., 2009, Wenzl and Grosshans, 2007, Neisch et al., 2007, Mulinari et al., 2007, Zhang et al., 2007, Fox et al., 2005, Luo, 2007.3.23, Padash Barmchi et al., 2005, Stramer et al., 2005, Brodu and Casanova, 2006, Rogers et al., 2003, Sommer et al., 2005, Vidal et al., 2006, Simoes et al., 2006, Avet-Rochex et al., 2005, Dean and Spudich, 2006, Kadandale et al., 2010, He et al., 2005, Lovegrove et al., 2006, Quinones-Coello, 2007, Bakal et al., 2007, Fox and Peifer, 2007, Polaski et al., 2006, Patch et al., 2008, Artabazon et al., 2008, Benjamin et al., 2008, Xu et al., 2008, Morgan and Kalm, 2008, Koelsch and Leptin, 2008, Bakal et al., 2007, Vig et al., 2006, Larson et al., 2008, Chen et al., 2005, Minidorff et al., 2007, Zhou et al., 2008, Betson and Settleman, 2007, Minidorff et al., 2007, Hickson and O'Farrell, 2008, Johnson et al., 2008, Taniguchi et al., 2007, Homem and Peifer, 2008, Paladi and Tepass, 2004, Williams et al., 2007, Matusek et al., 2008, Xu et al., 2008, Alves-Silva et al., 2008, Frank et al., 2009, Webb et al., 2009, Widmann and Dahmann, 2009, Snee and Macdonald, 2009, Dworkin et al., 2009, Liu et al., 2009, Asensio et al., 2010, Massarwa et al., 2009, Yan et al., 2009, Zeitlinger et al., 2007, Cordero et al., 2007, Warner and Longmore, 2009, Rothenfluh et al., 2006, Mirouse et al., 2009, Warner and Longmore, 2009, Patch et al., 2009, Sato et al., 2010, Zimmerman et al., 2010, Campos et al., 2010, Sekyrova et al., 2010, Pataki et al., 2010, Neisch et al., 2010, von Hilchen et al., 2010, Renault et al., 2010, Warner, 2010.9.15, Blanchard et al., 2010, Wang and Riechmann, 2007, Yu et al., 2010, Beltran et al., 2007, Song and Giniger, 2011, Simões et al., 2010, Tanaka et al., 2011, van Impel et al., 2009, Hughes et al., 2010, Ball et al., 2010) rho1 (Echard et al., 2004, Cafferty et al., 2005, Somma et al., 2002, Settleman, 2001, Jacinto et al., 2002, Schock and Perrimon, 2002, Somma et al., 2001, Nolan et al., 1998, Artabazon et al., 2007, Dworkin and Gibson, 2006, Dean et al., 2005, Wang and Riechmann, 2007, Sarkar et al., 2007, van Impel et al., 2009, Verdier et al., 2006, Higuchi et al., 2009, Bertet et al., 2009, Shao et al., 2010, Neubueser and Hipfner, 2010, Pilgram et al., 2011) RHO1 (Mirey et al., 2003) RhoA (Kerkhoff, 2006, Hu, 2005, Zhu et al., 2005, Govek, 2005, Wilson et al., 2005, Shandala et al., 2004, Harden et al., 2002, Balasubramanian et al., 2004, Wilk et al., 2004, Ishimaru et al., 2004, Polesello and Payre, 2004, Strutt and Strutt, 2003, Goda and Davis, 2003, Starz-Gaiano and Montell, 2004, Bayer et al., 2003, Ghabrial et al., 2003, Halsell et al., 2004, Jacinto and Baum, 2003, Solnica-Krezel and Eaton, 2003, Strutt, 2003, Strutt and Strutt, 2003, Pasterkamp and Kolodkin, 2003, Adler and Lee, 2001, Patel and Van Vactor, 2002, Wood et al., 2002, Acebes and Ferrus, 2000, Gao and Bogert, 2003, Echard and O'Farrell, 2003, Adler, 2002, Tree et al., 2002, Mlodzik, 2002, Aigaki et al., 2002, Tan et al., 2003, Castellani and Rougon, 2002, Wedlich, 2002, Lee et al., 2003, Schumacher et al., 2003, von Kalm et al., 2002, Bloor and Kiehart, 2002, Strutt et al., 2002, Kolodziej and Lee, 2002, Bloor and Kiehart, 2001, Wiemann et al., 2001, O'Keefe et al., 2000, Lee and Kolodziej, 2002, Billuart et al., 2001, Whitford and Ghosh, 2001, Bloor and Kiehart, 2001, Johnstone and Lasko, 2001, Hu et al., 2001, Billuart et al., 2001, Cooper and Strutt, 2001, Das and Mlodzik, 2001, Strutt, 2001, Winter et al., 2001, Winter et al., 2001, Pilch et al., 2001, Somers et al., 2001, Uchida et al., 2001, Sotillos and Campuzano, 2000, Fanto, 2000, Fanto et al., 2000, Newsome et al., 2000, Halsell et al., 2000, Pazman et al., 2000, Mlodzik, 2000, Lee et al., 2000, Halsell and Kiehart, 2000, Peifer and Tepass, 2000, Mlodzik, 1999, Kollmar, 1999, Rangarajan et al., 1999, Paricio et al., 1999, Sawamoto et al., 1999, Thomas and Wassarman, 1999, Reifegerste and Moses, 1999, Sawamoto et al., 1999, Sutherland and Witke, 1999, Lee et al., 1999, Harden et al., 1999, Harden et al., 1999, Halsell and Kiehart, 1999, Asha et al., 1999, Goberdhan and Wilson, 1998, Shulman et al., 1998, Boutros et al., 1998, Tree and Gubb, 1998, Axelrod et al., 1998, Dale, 1998, Strutt et al., 1997, Martin-Blanco, 1997, Eaton, 1997, Van Aelst and D'Souza-Schorey, 1997, Strutt et al., 1997, Ng and Luo, 2005, Matusek et al., 2005, Ruggiero et al., 2006, Fox and Kalm, 2006, Tyler et al., 2007, Impel et al., 2007, Matusek et al., 2006, McBride et al., 2006, Gregory et al., 2007, Mirkovic and Mlodzik, 2006, Roubinet et al., 2007, Nahm et al., 2006, Tolwinski, 2007, Sanny et al., 2006, Chung et al., 2007, Srahna et al., 2006, Mirkovic et al., 2011, Morgan and Kalm, 2008, Gregory et al., 2008, D'Avino et al., 2005, Taniguchi et al., 2007, Montrasio et al., 2007, Corrigall et al., 2007, Bastock and Strutt, 2007, Piekny et al., 2005, Carreno et al., 2008, Albertson et al., 2008, Cao et al., 2008, Llense and Martín-Blanco, 2008, Minin et al., 2006, Bidla et al., 2007, Rodriguez-Diaz et al., 2008, Schotman et al., 2009, Franke et al., 2007, Cao et al., 2010, Pataki et al., 2010, Matusek et al., 2008, Blanchard et al., 2010, Colinet et al., 2010, Zeng et al., 2010, Ben El Kadhi et al., 2011, Matsubara et al., 2011) rhoA (Brumby et al., 2004, Kockel et al., 2001, Grueber and Jan, 2004, Pandur et al., 2002, Jacinto et al., 2002, Zhu et al., 2002, Kadam and Reuter, 2001, Hemavathy et al., 2000, Schock and Perrimon, 2000, Stronach and Perrimon, 1999, Boutros and Mlodzik, 1999, Cox and Peifer, 1998, Cadigan and Nusse, 1997, Molnar and de Celis, 2006, Jenny et al., 2005, Yang and Bashaw, 2006, Asensio et al., 2010, Chung et al., 2009, Djiane and Mlodzik, 2010) Rho A (Dawes-Hoang and Wieschaus, 2001) Rho GTPase (Miller, 2003, Vincent and Magee, 2002) Rho kinase (Kiehart, 2003, Barros et al., 2003) RhoN19 (Blanchard et al., 2010)
Name Synonym	Rho1 (Prokopenko and Chia, 2008, Zhou et al., 2008, Zimmerman et al., 2010, Cammarato et al., 2011) rho1 (Verdier et al., 2006) rho1 kinase (Dworkin and Gibson., 2006) RhoA (Fanto and McNeill, 2004) Rho GTPase (Sepp and Auld, 2003, Xu et al., 2007) Rho kinase (Nikolaidou and Barrett, 2005, Mok et al., 2005) rho kinase (Dworkin and Gibson, 2006)
Secondary FlyBase IDs
	FBgn0014021 FBgn0024874 FBgn0024880
References ( 489 )
Generate a list of	All references relating to this gene ( 489 )
List References by type	Research paper  ( 235 ) Supplementary material  ( 15 ) Review  ( 98 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 114 ) FlyBase analysis  ( 3 ) Conference report  ( 2 ) Computer file  ( 4 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Thesis  ( 1 )
Recent research papers ( 35 )
	Bassi et al., 2011, J. Cell Biol. 195(4): 595--603 Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis. [FBrf0216679] Ben El Kadhi et al., 2011, Curr. Biol. 21(12): 1074--1079 The Inositol 5-Phosphatase dOCRL Controls PI(4,5)P2 Homeostasis and Is Necessary for Cytokinesis. [FBrf0213972] Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Koppen et al., 2011, Proteomics 11(22): 4397--4410 Proteomics analyses of microvesicles released by Drosophila Kc167 and S2 cells. [FBrf0216610] Matsubara et al., 2011, Genes Dev. 25(18): 1982--1996 The seven-pass transmembrane cadherin Flamingo controls dendritic self-avoidance via its binding to a LIM domain protein, Espinas, in Drosophila sensory neurons. [FBrf0215818] Pilgram et al., 2011, J. Neurosci. 31(2): 492--500 The RhoGAP crossveinless-c Interacts with Dystrophin and Is Required for Synaptic Homeostasis at the Drosophila Neuromuscular Junction. [FBrf0212767] Pollarolo et al., 2011, Nat. Neurosci. 14(12): 1525--1533 Cytokinesis remnants define first neuronal asymmetry in vivo. [FBrf0216761] Song and Giniger, 2011, Dev. Dyn. 240(2): 324--332 Noncanonical notch function in motor axon guidance is mediated by Rac GTPase and the GEF1 domain of trio. [FBrf0212819] Tanaka et al., 2011, Development 138(12): 2523--2532 Drosophila Mon2 couples Oskar-induced endocytosis with actin remodeling for cortical anchorage of the germ plasm. [FBrf0213769] Vanzomeren-Dohm et al., 2011, BMC Dev. Biol. 11: 41 The Drosophila Netrin receptor frazzled/DCC functions as an invasive tumor suppressor. [FBrf0214535] Asensio et al., 2010, J. Cell Biol. 191(6): 1173--1187 RNAi screen identifies a role for adaptor protein AP-3 in sorting to the regulated secretory pathway. [FBrf0212515] Ball et al., 2010, Neuron 66(4): 536--549 Retrograde BMP Signaling Controls Synaptic Growth at the NMJ by Regulating Trio Expression in Motor Neurons. [FBrf0210920] Blanchard et al., 2010, Development 137(16): 2743--2752 Cytoskeletal dynamics and supracellular organisation of cell shape fluctuations during dorsal closure. [FBrf0211395] Campos et al., 2010, Genetics 184(1): 129--140 Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. [FBrf0209682] Cao et al., 2010, Curr. Biol. 20(8): 770--776 Cortical Actin Dynamics Facilitate Early-Stage Centrosome Separation. [FBrf0211162] Colinet et al., 2010, PLoS Pathog. 6(11): e1001206 The origin of intraspecific variation of virulence in an eukaryotic immune suppressive parasite. [FBrf0212464] Djiane and Mlodzik, 2010, PLoS ONE 5(6): e11228 The Drosophila GIPC homologue can modulate myosin based processes and planar cell polarity but is not essential for development. [FBrf0211141] Elsaesser et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(10): 4740--4745 Light-induced translocation of Drosophila visual Arrestin2 depends on Rac2. [FBrf0210213] Goldbach et al., 2010, Mol. Biol. Cell 21(9): 1482--1493 Stabilization of the actomyosin ring enables spermatocyte cytokinesis in Drosophila. [FBrf0210683] He et al., 2010, Nat. Cell Biol. 12(12): 1133--1142 Tissue elongation requires oscillating contractions of a basal actomyosin network. [FBrf0212453] Hughes et al., 2010, J. Cell Sci. 123(7): 1099--1107 Sip1, the Drosophila orthologue of EBP50/NHERF1, functions with the sterile 20 family kinase Slik to regulate Moesin activity. [FBrf0210408] Kadandale et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(23): 10502--10507 Conserved role for autophagy in Rho1-mediated cortical remodeling and blood cell recruitment. [FBrf0210996] Neisch et al., 2010, J. Cell Biol. 189(2): 311--323 Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane. [FBrf0210554] Neubueser and Hipfner, 2010, Mol. Biol. Cell 21(16): 2869--2879 Overlapping roles of Drosophila drak and rok kinases in epithelial tissue morphogenesis. [FBrf0211530] Pataki et al., 2010, Genetics 184(4): 1051--1065 Drosophila Rab23 is involved in the regulation of the number and planar polarization of the adult cuticular hairs. [FBrf0210720] Renault et al., 2010, Development 137(11): 1815--1823 Lipid phosphate phosphatase activity regulates dispersal and bilateral sorting of embryonic germ cells in Drosophila. [FBrf0210764] Sato et al., 2010, Genes Cells 15(5): 485--500 Crossveinless-c, the Drosophila homolog of tumor suppressor DLC1, regulates directional elongation of dendritic branches via down-regulating Rho1 activity. [FBrf0211000] Sekyrova et al., 2010, Development 137(1): 141--150 Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis. [FBrf0209550] Shao et al., 2010, PLoS ONE 5(4): e9938 A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium. [FBrf0210449] Simões et al., 2010, Dev. Cell 19(3): 377--388 Rho-Kinase Directs Bazooka/Par-3 Planar Polarity during Drosophila Axis Elongation. [FBrf0211783] Uehara et al., 2010, Curr. Biol. 20(12): 1080--1085 Determinants of Myosin II Cortical Localization during Cytokinesis. [FBrf0211160] von Hilchen et al., 2010, Development 137(8): 1251--1262 Netrins guide migration of distinct glial cells in the Drosophila embryo. [FBrf0210391] Yu et al., 2010, J. Neurosci. 30(36): 12151--12156 Plexin a-semaphorin-1a reverse signaling regulates photoreceptor axon guidance in Drosophila. [FBrf0211784] Zeng et al., 2010, J. Cell. Physiol. 224(3): 766--774 Tumor suppressors Sav/scrib and oncogene ras regulate stem-cell transformation in adult Drosophila malpighian tubules. [FBrf0211181] Zimmerman et al., 2010, Dev. Biol. 340(1): 54--66 Apical constriction and invagination downstream of the canonical Wnt signaling pathway require Rho1 and Myosin II. [FBrf0210185] Show all research papers ...
Recent reviews ( 1 )
	Gregory et al., 2010, IUBMB Life 62(4): 290--295 Signalling through the RhoGEF Pebble in Drosophila. [FBrf0210431] Show all reviews ...