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Gene Dmel\Rho1

General Information
Symbol	Dmel\Rho1	Species	D. melanogaster
Name	Rho1	Annotation symbol	CG8416
Feature type	protein_coding_gene	FlyBase ID	FBgn0014020
Gene Model Status	Current	Stock availability	38 publicly available
Also Known As	RhoA, Rho, dRhoA, DRho1, Rho kinase, Rho GTPase
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	52E5-52E5	Sequence location	2R:11,990,192..11,994,734 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Rho1 is referred to in FlyBase by the symbol Dmel\Rho1 (CG8416, FBgn0014020). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; kinase binding. There is experimental evidence for 42 unique biological process terms, many of which group under: single-organism developmental process; cellular component organization or biogenesis; biological regulation; localization; open tracheal system development; cellular component movement; actin filament-based process; embryonic development via the syncytial blastoderm; organelle organization; response to stress; neuron differentiation. 70 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; non-connected developing system; external compound sense organ; portion of tissue; late extended germ band embryo; extended germ band embryo; peripheral nervous system; multicellular structure; cytoplasmic part; spiracle; adult segment. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Small GTP-binding protein domain; Small GTPase superfamily; Small GTPase superfamily, Rho type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. Gene sequence location is 2R:11990192..11994734.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms cortical actin cytoskeleton organization
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 52E5-52E5   Limits computationally determined from genome sequence between P{PZ}l(2)0507005070&P{EP}CG8414EP525 and P{EP}spinEP645&P{lacW}spink09905
Experimentally Determined Cytological Location
Cytogenetic map Notes References   Cytological location reported in FBrf0080078 was in error.     52E-52E     (Magie, 1999.8.17) 52E-52E   (determined by in situ hybridisation)   (Magie et al., 1999) 52E5-52E6   (determined by in situ hybridisation)   (Spradling et al., 1999) 52E3-52E6   (determined by in situ hybridisation)   (Strutt et al., 1997) 52D-52D   (determined by in situ hybridisation)   (Sasamura, 1995) 3C-3C   (determined by in situ hybridisation)   (Hariharan et al., 1995) 52E5-52E6     (BDGP Project Members, 1994-1999) 52E2-52E9   Hybridization of Rho1 cDNA to Df(2R)KL32 and Df(2R)Jp6 confirmed that Rho1 maps to 52E. (determined by in situ hybridisation)   (Sasamura et al., 1997) 52E3-52E6   Cytological location reported in FBrf0080078 was in error. (determined by in situ hybridisation)   (Settleman and Hariharan, 1997.8.8)
Experimentally Determined Recombination Data
Location	2-
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Rho1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Rho1-RA FBtr0087211  NM_057750   1288   192 Rho1-RB FBtr0087212  NM_134308   2028   192 Rho1-RC FBtr0087213  NM_134309   1899   192 Rho1-RD FBtr0087214  NM_166139   1243   192 Rho1-RF FBtr0087216  NM_206128   1971   192 Rho1-RG FBtr0087217  NM_206127   1975   192
Additional Transcript Data & Comments
Reported size (kB)	3.7, 3.1, 2.1 (northern blot); 1.3 (unknown) (Magie et al., 1999) 1.467 (longest cDNA) (Hariharan et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Rho1-PA   FBpp0086353   21.7   192   7.06     NP_477098   AAM70944 Rho1-PB   FBpp0086354   21.7   192   7.06     NP_599135   AAF58066 Rho1-PC   FBpp0086355   21.7   192   7.06     NP_599136   AAM70945 Rho1-PD   FBpp0086356   21.7   192   7.06     NP_725524   AAM70946 Rho1-PF   FBpp0089129   21.7   192   7.06     NP_995850   AAS64843 Rho1-PG   FBpp0089130   21.7   192   7.06     NP_995849   AAS64844
Additional Polypeptide Data & Comments
Reported size (kDa)	192 (aa) (Hariharan et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Small GTPase superfamily (IPR001806) Small GTPase superfamily, Rho type (IPR003578) Small GTP-binding protein domain (IPR005225) P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202784   AA391196   AA694683   AA695628   AA735703   AA802622   AA802783   AA816258   AA817053   AA949454   AA952270   AE013599 AAF58066   AE013599 AAM70944   AE013599 AAM70945   AE013599 AAM70946   AE013599 AAS64843   AE013599 AAS64844   AC004248   AF177871 AAF01183   AF177872 AAF01184   AF177873 AAF01185   AF177874 AAF01186   AI135759   AI239017   AI257703   AI294261   AI389565   AI513351   AW940792   AW941520   AY119536 AAM50190   AY432013   BF495178   BG636136   BI161597   BI161598   BI162525   BI162526   BI163292   BI164637   BI165104   BI165570   BI165877   BI166028   BI169325   BI214262   BI215147   BI227920   BI231031   BI234630   BI238440   BI238583   BI239321   BI241605   BI356759   BI361565   BI361584   BI362069   BI362544   BI362780   BI366426   BI367070   BI367429   BI367510   BI368645   BI368936   BI370112   BI374913   BI376156   BI481582   BI482701   BI487064   BI564367   BI569182   BI569183   BI575188   BI576690   BI579900   BI589315   BI590559   BI604686   BI605229   BI605555   BI605882   BI606348   BI606784   BI606829   BI607872   BI609659   BI609807   BI610789   BI611133   BI614834   BI616115   BI616247   BI619407   BI621206   BI623475   BI624050   BI629139   BI629458   BI630392   BI630939   BI638865   BP548744   BP549286   BP549287   BP551502   BP551503   BP556255   BP557976   BP560112   BT010085 AAQ22554   BT030133   BT030848   CA804415   CA807762   CK657168   CO181427   CO181605   CO183371   CO183593   CO187194   CO188444   CO265494   CO267587   CO275313   CO280485   CO281822   CO283057   CO286515   CO296814   CO299865   CO300386   CO302704   CO303880   CO304272   CO308692   CO319127   CO324269   CO338075   CS026563 CAI61748   CZ466213   CZ466317   CZ466328   CZ466342   CZ466702   CZ472750   CZ475601   CZ475602   CZ475782   EC060482   EC061692   EC064343   EC065171   EC073756   EC078037   EC078530   EC084306   EC086203   EC089155   EC200810   EC202676   EC203944   EC206460   EC210707   EC211085   EC213726   EC213941   EC213986   EC218092   EC222250   EC223206   EC234397   EC234901   EC245644   EC262511   ES692256   ES696614   ES696616   EV592978   EV594078   EV594208   EV599974   L38311
UniProtKB/Swiss-Prot	P48148
UniProtKB/TrEMBL	A4UZI6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Hariharan et al., 1995) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) central brain primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Sasamura et al., 1997) embryonic stage -- adult stage     (Magie et al., 1999, Sasamura et al., 1997) P-stage   organism   (Magie et al., 1999) Comment:female pupal stage   organism   (Magie et al., 1999) Comment:female adult stage | female   organism   (Magie et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cell cortex inferred from direct assay (Rosales-Nieves et al., 2006) cell hair inferred from direct assay (Yan et al., 2009) cytoplasm inferred from direct assay (Yan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    240 central nervous system, larvae L3    693 central nervous system, pupae P8    540 head, virgin 1-day female    319 head, virgin 4-day female    441 head, virgin 20-day female    121 head, mated 1-day female    472 head, mated 4-day female    374 head, mated 20-day female    196 head, mated 1-day male    331 head, mated 4-day male    449 head, mated 20-day male    440 salivary gland, larvae L3 wandering    414 salivary gland, white prepupae    669 digestive system, larvae L3 wandering    806 digestive system, 1-day adult    351 digestive system, 4-day adult    552 digestive system, 20-day adult    387 fat body, larvae L3 wandering    593 fat body, white prepupae    490 fat body, pupae P8    543 carcass, larvae L3 wandering    438 carcass, 1-day adult    334 carcass, 4-day adult    388 carcass, 20-day adult    342 ovary, virgin 4-day female    214 ovary, mated 4-day female    564 testis, mated 4-day male    106 accessory gland, mated 4-day male    239 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (240) central nervous system, larvae L3  (693) central nervous system, pupae P8  (540) head, virgin 1-day female  (319) head, virgin 4-day female  (441) head, virgin 20-day female  (121) head, mated 1-day female  (472) head, mated 4-day female  (374) head, mated 20-day female  (196) head, mated 1-day male  (331) head, mated 4-day male  (449) head, mated 20-day male  (440) salivary gland, larvae L3 wandering  (414) salivary gland, white prepupae  (669) digestive system, larvae L3 wandering  (806) digestive system, 1-day adult  (351) digestive system, 4-day adult  (552) digestive system, 20-day adult  (387) fat body, larvae L3 wandering  (593) fat body, white prepupae  (490) fat body, pupae P8  (543) carcass, larvae L3 wandering  (438) carcass, 1-day adult  (334) carcass, 4-day adult  (388) carcass, 20-day adult  (342) ovary, virgin 4-day female  (214) ovary, mated 4-day female  (564) testis, mated 4-day male  (106) accessory gland, mated 4-day male  (239) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (240) central nervous system, larvae L3  (693) central nervous system, pupae P8  (540) head, virgin 1-day female  (319) head, virgin 4-day female  (441) head, virgin 20-day female  (121) head, mated 1-day female  (472) head, mated 4-day female  (374) head, mated 20-day female  (196) head, mated 1-day male  (331) head, mated 4-day male  (449) head, mated 20-day male  (440) salivary gland, larvae L3 wandering  (414) salivary gland, white prepupae  (669) digestive system, larvae L3 wandering  (806) digestive system, 1-day adult  (351) digestive system, 4-day adult  (552) digestive system, 20-day adult  (387) fat body, larvae L3 wandering  (593) fat body, white prepupae  (490) fat body, pupae P8  (543) carcass, larvae L3 wandering  (438) carcass, 1-day adult  (334) carcass, 4-day adult  (388) carcass, 20-day adult  (342) ovary, virgin 4-day female  (214) ovary, mated 4-day female  (564) testis, mated 4-day male  106 accessory gland, mated 4-day male  (239) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    240 central nervous system, larvae L3    693 central nervous system, pupae P8    540 head, virgin 1-day female    319 head, virgin 4-day female    441 head, virgin 20-day female    121 head, mated 1-day female    472 head, mated 4-day female    374 head, mated 20-day female    196 head, mated 1-day male    331 head, mated 4-day male    449 head, mated 20-day male    440 salivary gland, larvae L3 wandering    414 salivary gland, white prepupae    669 digestive system, larvae L3 wandering    806 digestive system, 1-day adult    351 digestive system, 4-day adult    552 digestive system, 20-day adult    387 fat body, larvae L3 wandering    593 fat body, white prepupae    490 fat body, pupae P8    543 carcass, larvae L3 wandering    438 carcass, 1-day adult    334 carcass, 4-day adult    388 carcass, 20-day adult    342 ovary, virgin 4-day female    214 ovary, mated 4-day female    564 testis, mated 4-day male    106 accessory gland, mated 4-day male    239 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    240 central nervous system, larvae L3    693 central nervous system, pupae P8    540 head, virgin 1-day female    319 head, virgin 4-day female    441 head, virgin 20-day female    121 head, mated 1-day female    472 head, mated 4-day female    374 head, mated 20-day female    196 head, mated 1-day male    331 head, mated 4-day male    449 head, mated 20-day male    440 salivary gland, larvae L3 wandering    414 salivary gland, white prepupae    669 digestive system, larvae L3 wandering    806 digestive system, 1-day adult    351 digestive system, 4-day adult    552 digestive system, 20-day adult    387 fat body, larvae L3 wandering    593 fat body, white prepupae    490 fat body, pupae P8    543 carcass, larvae L3 wandering    438 carcass, 1-day adult    334 carcass, 4-day adult    388 carcass, 20-day adult    342 ovary, virgin 4-day female    214 ovary, mated 4-day female    564 testis, mated 4-day male    106 accessory gland, mated 4-day male    239 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (240) central nervous system, larvae L3  (693) central nervous system, pupae P8  (540) head, virgin 1-day female  (319) head, virgin 4-day female  (441) head, virgin 20-day female  (121) head, mated 1-day female  (472) head, mated 4-day female  (374) head, mated 20-day female  (196) head, mated 1-day male  (331) head, mated 4-day male  (449) head, mated 20-day male  (440) salivary gland, larvae L3 wandering  (414) salivary gland, white prepupae  (669) digestive system, larvae L3 wandering  (806) digestive system, 1-day adult  (351) digestive system, 4-day adult  (552) digestive system, 20-day adult  (387) fat body, larvae L3 wandering  (593) fat body, white prepupae  (490) fat body, pupae P8  (543) carcass, larvae L3 wandering  (438) carcass, 1-day adult  (334) carcass, 4-day adult  (388) carcass, 20-day adult  (342) ovary, virgin 4-day female  (214) ovary, mated 4-day female  (564) testis, mated 4-day male  (106) accessory gland, mated 4-day male  (239) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (240) central nervous system, larvae L3  (693) central nervous system, pupae P8  (540) head, virgin 1-day female  (319) head, virgin 4-day female  (441) head, virgin 20-day female  121 head, mated 1-day female  (472) head, mated 4-day female  (374) head, mated 20-day female  (196) head, mated 1-day male  (331) head, mated 4-day male  (449) head, mated 20-day male  (440) salivary gland, larvae L3 wandering  (414) salivary gland, white prepupae  (669) digestive system, larvae L3 wandering  (806) digestive system, 1-day adult  (351) digestive system, 4-day adult  (552) digestive system, 20-day adult  (387) fat body, larvae L3 wandering  (593) fat body, white prepupae  (490) fat body, pupae P8  (543) carcass, larvae L3 wandering  (438) carcass, 1-day adult  (334) carcass, 4-day adult  (388) carcass, 20-day adult  (342) ovary, virgin 4-day female  (214) ovary, mated 4-day female  (564) testis, mated 4-day male  106 accessory gland, mated 4-day male  (239) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    240 central nervous system, larvae L3    693 central nervous system, pupae P8    540 head, virgin 1-day female    319 head, virgin 4-day female    441 head, virgin 20-day female    121 head, mated 1-day female    472 head, mated 4-day female    374 head, mated 20-day female    196 head, mated 1-day male    331 head, mated 4-day male    449 head, mated 20-day male    440 salivary gland, larvae L3 wandering    414 salivary gland, white prepupae    669 digestive system, larvae L3 wandering    806 digestive system, 1-day adult    351 digestive system, 4-day adult    552 digestive system, 20-day adult    387 fat body, larvae L3 wandering    593 fat body, white prepupae    490 fat body, pupae P8    543 carcass, larvae L3 wandering    438 carcass, 1-day adult    334 carcass, 4-day adult    388 carcass, 20-day adult    342 ovary, virgin 4-day female    214 ovary, mated 4-day female    564 testis, mated 4-day male    106 accessory gland, mated 4-day male    239 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of high expression. Peak expression observed at stages throughout embryogenesis, during late larval stages, at stages throughout the pupal period. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    151 embryo 04-06hr    192 embryo 06-08hr    190 embryo 08-10hr    198 embryo 10-12hr    211 embryo 12-14hr    240 embryo 14-16hr    119 embryo 16-18hr    163 embryo 18-20hr    112 embryo 20-22hr    105 embryo 22-24hr    147 larva L1    105 larva L2    105 larva L3 12hr old    99 larva L3 puffstage 1-2    123 larva L3 puffstage 3-6    179 larva L3 puffstage 7-9    263 white prepupae new    255 white prepupae 12hr    207 white prepupae 24hr    179 pupae 2d postWPP    155 pupae 3d postWPP    105 pupae 4d postWPP    69 adult male 01day    85 adult male 05day    80 adult male 30day    77 adult female 01day    70 adult female 05day    95 adult female 30day    93 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (81) embryo 02-04hr  (151) embryo 04-06hr  (192) embryo 06-08hr  (190) embryo 08-10hr  (198) embryo 10-12hr  (211) embryo 12-14hr  (240) embryo 14-16hr  (119) embryo 16-18hr  (163) embryo 18-20hr  (112) embryo 20-22hr  (105) embryo 22-24hr  (147) larva L1  (105) larva L2  (105) larva L3 12hr old  (99) larva L3 puffstage 1-2  (123) larva L3 puffstage 3-6  (179) larva L3 puffstage 7-9  (263) white prepupae new  (255) white prepupae 12hr  (207) white prepupae 24hr  (179) pupae 2d postWPP  (155) pupae 3d postWPP  (105) pupae 4d postWPP  (69) adult male 01day  (85) adult male 05day  (80) adult male 30day  (77) adult female 01day  (70) adult female 05day  (95) adult female 30day  (93) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr  (151) embryo 04-06hr  (192) embryo 06-08hr  (190) embryo 08-10hr  (198) embryo 10-12hr  (211) embryo 12-14hr  (240) embryo 14-16hr  (119) embryo 16-18hr  (163) embryo 18-20hr  (112) embryo 20-22hr  105 embryo 22-24hr  (147) larva L1  105 larva L2  105 larva L3 12hr old    99 larva L3 puffstage 1-2  (123) larva L3 puffstage 3-6  (179) larva L3 puffstage 7-9  (263) white prepupae new  (255) white prepupae 12hr  (207) white prepupae 24hr  (179) pupae 2d postWPP  (155) pupae 3d postWPP  105 pupae 4d postWPP    69 adult male 01day    85 adult male 05day    80 adult male 30day    77 adult female 01day    70 adult female 05day    95 adult female 30day    93 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    151 embryo 04-06hr    192 embryo 06-08hr    190 embryo 08-10hr    198 embryo 10-12hr    211 embryo 12-14hr    240 embryo 14-16hr    119 embryo 16-18hr    163 embryo 18-20hr    112 embryo 20-22hr    105 embryo 22-24hr    147 larva L1    105 larva L2    105 larva L3 12hr old    99 larva L3 puffstage 1-2    123 larva L3 puffstage 3-6    179 larva L3 puffstage 7-9    263 white prepupae new    255 white prepupae 12hr    207 white prepupae 24hr    179 pupae 2d postWPP    155 pupae 3d postWPP    105 pupae 4d postWPP    69 adult male 01day    85 adult male 05day    80 adult male 30day    77 adult female 01day    70 adult female 05day    95 adult female 30day    93 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    151 embryo 04-06hr    192 embryo 06-08hr    190 embryo 08-10hr    198 embryo 10-12hr    211 embryo 12-14hr    240 embryo 14-16hr    119 embryo 16-18hr    163 embryo 18-20hr    112 embryo 20-22hr    105 embryo 22-24hr    147 larva L1    105 larva L2    105 larva L3 12hr old    99 larva L3 puffstage 1-2    123 larva L3 puffstage 3-6    179 larva L3 puffstage 7-9    263 white prepupae new    255 white prepupae 12hr    207 white prepupae 24hr    179 pupae 2d postWPP    155 pupae 3d postWPP    105 pupae 4d postWPP    69 adult male 01day    85 adult male 05day    80 adult male 30day    77 adult female 01day    70 adult female 05day    95 adult female 30day    93 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (81) embryo 02-04hr  (151) embryo 04-06hr  (192) embryo 06-08hr  (190) embryo 08-10hr  (198) embryo 10-12hr  (211) embryo 12-14hr  (240) embryo 14-16hr  (119) embryo 16-18hr  (163) embryo 18-20hr  (112) embryo 20-22hr  (105) embryo 22-24hr  (147) larva L1  (105) larva L2  (105) larva L3 12hr old  (99) larva L3 puffstage 1-2  (123) larva L3 puffstage 3-6  (179) larva L3 puffstage 7-9  (263) white prepupae new  (255) white prepupae 12hr  (207) white prepupae 24hr  (179) pupae 2d postWPP  (155) pupae 3d postWPP  (105) pupae 4d postWPP  (69) adult male 01day  (85) adult male 05day  (80) adult male 30day  (77) adult female 01day  (70) adult female 05day  (95) adult female 30day  (93) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr  (151) embryo 04-06hr  (192) embryo 06-08hr  (190) embryo 08-10hr  (198) embryo 10-12hr  (211) embryo 12-14hr  (240) embryo 14-16hr  119 embryo 16-18hr  (163) embryo 18-20hr  112 embryo 20-22hr  105 embryo 22-24hr  (147) larva L1  105 larva L2  105 larva L3 12hr old    99 larva L3 puffstage 1-2  123 larva L3 puffstage 3-6  (179) larva L3 puffstage 7-9  (263) white prepupae new  (255) white prepupae 12hr  (207) white prepupae 24hr  (179) pupae 2d postWPP  (155) pupae 3d postWPP  105 pupae 4d postWPP    69 adult male 01day    85 adult male 05day    80 adult male 30day    77 adult female 01day    70 adult female 05day    95 adult female 30day    93 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    81 embryo 02-04hr    151 embryo 04-06hr    192 embryo 06-08hr    190 embryo 08-10hr    198 embryo 10-12hr    211 embryo 12-14hr    240 embryo 14-16hr    119 embryo 16-18hr    163 embryo 18-20hr    112 embryo 20-22hr    105 embryo 22-24hr    147 larva L1    105 larva L2    105 larva L3 12hr old    99 larva L3 puffstage 1-2    123 larva L3 puffstage 3-6    179 larva L3 puffstage 7-9    263 white prepupae new    255 white prepupae 12hr    207 white prepupae 24hr    179 pupae 2d postWPP    155 pupae 3d postWPP    105 pupae 4d postWPP    69 adult male 01day    85 adult male 05day    80 adult male 30day    77 adult female 01day    70 adult female 05day    95 adult female 30day    93 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    521 Schneider line 2 Sg4    443 embryonic 1182-4H    1002 embryonic GM2    866 embryonic Kc167    656 embryonic S1    517 embryonic S3    376 leg disc CME L1    592 wing disc CME-W2    775 wing disc ML-DmD8    588 wing disc ML-DmD9    673 wing disc ML-DmD16-c3    1269 wing disc ML-DmD21    463 wing disc ML-DmD32    1007 haltere disc ML-DmD17-c3    635 eye-antennal disc ML-DmD11    506 antennal disc ML-DmD20-c5    796 mixed discs ML-DmD4-c1    763 CNS ML-DmBG1-c1    1134 CNS ML-DmBG2-c2    492 tumorous blood cells mbn2    832 ovary fGS/OSS    1387 ovary OSC    2587 ovary OSS    1026 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (521) Schneider line 2 Sg4  (443) embryonic 1182-4H  (1002) embryonic GM2  (866) embryonic Kc167  (656) embryonic S1  (517) embryonic S3  (376) leg disc CME L1  (592) wing disc CME-W2  (775) wing disc ML-DmD8  (588) wing disc ML-DmD9  (673) wing disc ML-DmD16-c3  (1269) wing disc ML-DmD21  (463) wing disc ML-DmD32  (1007) haltere disc ML-DmD17-c3  (635) eye-antennal disc ML-DmD11  (506) antennal disc ML-DmD20-c5  (796) mixed discs ML-DmD4-c1  (763) CNS ML-DmBG1-c1  (1134) CNS ML-DmBG2-c2  (492) tumorous blood cells mbn2  (832) ovary fGS/OSS  (1387) ovary OSC  (2587) ovary OSS  (1026) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (521) Schneider line 2 Sg4  (443) embryonic 1182-4H  (1002) embryonic GM2  (866) embryonic Kc167  (656) embryonic S1  (517) embryonic S3  (376) leg disc CME L1  (592) wing disc CME-W2  (775) wing disc ML-DmD8  (588) wing disc ML-DmD9  (673) wing disc ML-DmD16-c3  (1269) wing disc ML-DmD21  (463) wing disc ML-DmD32  (1007) haltere disc ML-DmD17-c3  (635) eye-antennal disc ML-DmD11  (506) antennal disc ML-DmD20-c5  (796) mixed discs ML-DmD4-c1  (763) CNS ML-DmBG1-c1  (1134) CNS ML-DmBG2-c2  (492) tumorous blood cells mbn2  (832) ovary fGS/OSS  (1387) ovary OSC  (2587) ovary OSS  (1026) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    521 Schneider line 2 Sg4    443 embryonic 1182-4H    1002 embryonic GM2    866 embryonic Kc167    656 embryonic S1    517 embryonic S3    376 leg disc CME L1    592 wing disc CME-W2    775 wing disc ML-DmD8    588 wing disc ML-DmD9    673 wing disc ML-DmD16-c3    1269 wing disc ML-DmD21    463 wing disc ML-DmD32    1007 haltere disc ML-DmD17-c3    635 eye-antennal disc ML-DmD11    506 antennal disc ML-DmD20-c5    796 mixed discs ML-DmD4-c1    763 CNS ML-DmBG1-c1    1134 CNS ML-DmBG2-c2    492 tumorous blood cells mbn2    832 ovary fGS/OSS    1387 ovary OSC    2587 ovary OSS    1026 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    521 Schneider line 2 Sg4    443 embryonic 1182-4H    1002 embryonic GM2    866 embryonic Kc167    656 embryonic S1    517 embryonic S3    376 leg disc CME L1    592 wing disc CME-W2    775 wing disc ML-DmD8    588 wing disc ML-DmD9    673 wing disc ML-DmD16-c3    1269 wing disc ML-DmD21    463 wing disc ML-DmD32    1007 haltere disc ML-DmD17-c3    635 eye-antennal disc ML-DmD11    506 antennal disc ML-DmD20-c5    796 mixed discs ML-DmD4-c1    763 CNS ML-DmBG1-c1    1134 CNS ML-DmBG2-c2    492 tumorous blood cells mbn2    832 ovary fGS/OSS    1387 ovary OSC    2587 ovary OSS    1026 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (521) Schneider line 2 Sg4  (443) embryonic 1182-4H  (1002) embryonic GM2  (866) embryonic Kc167  (656) embryonic S1  (517) embryonic S3  (376) leg disc CME L1  (592) wing disc CME-W2  (775) wing disc ML-DmD8  (588) wing disc ML-DmD9  (673) wing disc ML-DmD16-c3  (1269) wing disc ML-DmD21  (463) wing disc ML-DmD32  (1007) haltere disc ML-DmD17-c3  (635) eye-antennal disc ML-DmD11  (506) antennal disc ML-DmD20-c5  (796) mixed discs ML-DmD4-c1  (763) CNS ML-DmBG1-c1  (1134) CNS ML-DmBG2-c2  (492) tumorous blood cells mbn2  (832) ovary fGS/OSS  (1387) ovary OSC  (2587) ovary OSS  (1026) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (521) Schneider line 2 Sg4  (443) embryonic 1182-4H  (1002) embryonic GM2  (866) embryonic Kc167  (656) embryonic S1  (517) embryonic S3  (376) leg disc CME L1  (592) wing disc CME-W2  (775) wing disc ML-DmD8  (588) wing disc ML-DmD9  (673) wing disc ML-DmD16-c3  (1269) wing disc ML-DmD21  (463) wing disc ML-DmD32  (1007) haltere disc ML-DmD17-c3  (635) eye-antennal disc ML-DmD11  (506) antennal disc ML-DmD20-c5  (796) mixed discs ML-DmD4-c1  (763) CNS ML-DmBG1-c1  (1134) CNS ML-DmBG2-c2  (492) tumorous blood cells mbn2  (832) ovary fGS/OSS  (1387) ovary OSC  (2587) ovary OSS  (1026) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    521 Schneider line 2 Sg4    443 embryonic 1182-4H    1002 embryonic GM2    866 embryonic Kc167    656 embryonic S1    517 embryonic S3    376 leg disc CME L1    592 wing disc CME-W2    775 wing disc ML-DmD8    588 wing disc ML-DmD9    673 wing disc ML-DmD16-c3    1269 wing disc ML-DmD21    463 wing disc ML-DmD32    1007 haltere disc ML-DmD17-c3    635 eye-antennal disc ML-DmD11    506 antennal disc ML-DmD20-c5    796 mixed discs ML-DmD4-c1    763 CNS ML-DmBG1-c1    1134 CNS ML-DmBG2-c2    492 tumorous blood cells mbn2    832 ovary fGS/OSS    1387 ovary OSC    2587 ovary OSS    1026 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    802 cold shock, 4-day adult    715 heat shock, 4-day adult    261 Cadmium 50 mM 6 hrs, larvae L3    197 Cadmium 50 mM 12 hrs, larvae L3    382 Cadmium 50 mM 48 hrs, 4-day adult    398 Cadmium 100 mM 48 hrs, 4-day adult    707 Copper 0.5 mM 12 hrs, larvae L3    673 Copper 15 mM 48 hrs, 4-day adult    810 Zinc 5 mM 12 hrs, larvae L3    808 Zinc 4.5 mM 48 hrs, 4-day adult    950 Ethanol 2.5% 3 hrs, larvae L3    185 Ethanol 5% 3 hrs, larvae L3    300 Ethanol 10% 3 hrs, larvae L3    273 Caffeine 1.5 mg/ml 4 hrs, larvae L3    256 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    615 Caffeine 25 mg/ml 48 hrs, 4-day adult    1030 Paraquat 5 mM 48 hrs, 4-day adult    500 Paraquat 10 mM 48 hrs, 4-day adult    250 Rotenone 2 μg 12 hrs, larvae L3    261 Rotenone 8 μg 12 hrs, larvae L3    109 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (802) cold shock, 4-day adult  (715) heat shock, 4-day adult  (261) Cadmium 50 mM 6 hrs, larvae L3  (197) Cadmium 50 mM 12 hrs, larvae L3  (382) Cadmium 50 mM 48 hrs, 4-day adult  (398) Cadmium 100 mM 48 hrs, 4-day adult  (707) Copper 0.5 mM 12 hrs, larvae L3  (673) Copper 15 mM 48 hrs, 4-day adult  (810) Zinc 5 mM 12 hrs, larvae L3  (808) Zinc 4.5 mM 48 hrs, 4-day adult  (950) Ethanol 2.5% 3 hrs, larvae L3  (185) Ethanol 5% 3 hrs, larvae L3  (300) Ethanol 10% 3 hrs, larvae L3  (273) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (256) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (615) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1030) Paraquat 5 mM 48 hrs, 4-day adult  (500) Paraquat 10 mM 48 hrs, 4-day adult  (250) Rotenone 2 μg 12 hrs, larvae L3  (261) Rotenone 8 μg 12 hrs, larvae L3  (109) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (802) cold shock, 4-day adult  (715) heat shock, 4-day adult  (261) Cadmium 50 mM 6 hrs, larvae L3  (197) Cadmium 50 mM 12 hrs, larvae L3  (382) Cadmium 50 mM 48 hrs, 4-day adult  (398) Cadmium 100 mM 48 hrs, 4-day adult  (707) Copper 0.5 mM 12 hrs, larvae L3  (673) Copper 15 mM 48 hrs, 4-day adult  (810) Zinc 5 mM 12 hrs, larvae L3  (808) Zinc 4.5 mM 48 hrs, 4-day adult  (950) Ethanol 2.5% 3 hrs, larvae L3  (185) Ethanol 5% 3 hrs, larvae L3  (300) Ethanol 10% 3 hrs, larvae L3  (273) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (256) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (615) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1030) Paraquat 5 mM 48 hrs, 4-day adult  (500) Paraquat 10 mM 48 hrs, 4-day adult  (250) Rotenone 2 μg 12 hrs, larvae L3  (261) Rotenone 8 μg 12 hrs, larvae L3  (109) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    802 cold shock, 4-day adult    715 heat shock, 4-day adult    261 Cadmium 50 mM 6 hrs, larvae L3    197 Cadmium 50 mM 12 hrs, larvae L3    382 Cadmium 50 mM 48 hrs, 4-day adult    398 Cadmium 100 mM 48 hrs, 4-day adult    707 Copper 0.5 mM 12 hrs, larvae L3    673 Copper 15 mM 48 hrs, 4-day adult    810 Zinc 5 mM 12 hrs, larvae L3    808 Zinc 4.5 mM 48 hrs, 4-day adult    950 Ethanol 2.5% 3 hrs, larvae L3    185 Ethanol 5% 3 hrs, larvae L3    300 Ethanol 10% 3 hrs, larvae L3    273 Caffeine 1.5 mg/ml 4 hrs, larvae L3    256 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    615 Caffeine 25 mg/ml 48 hrs, 4-day adult    1030 Paraquat 5 mM 48 hrs, 4-day adult    500 Paraquat 10 mM 48 hrs, 4-day adult    250 Rotenone 2 μg 12 hrs, larvae L3    261 Rotenone 8 μg 12 hrs, larvae L3    109 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    802 cold shock, 4-day adult    715 heat shock, 4-day adult    261 Cadmium 50 mM 6 hrs, larvae L3    197 Cadmium 50 mM 12 hrs, larvae L3    382 Cadmium 50 mM 48 hrs, 4-day adult    398 Cadmium 100 mM 48 hrs, 4-day adult    707 Copper 0.5 mM 12 hrs, larvae L3    673 Copper 15 mM 48 hrs, 4-day adult    810 Zinc 5 mM 12 hrs, larvae L3    808 Zinc 4.5 mM 48 hrs, 4-day adult    950 Ethanol 2.5% 3 hrs, larvae L3    185 Ethanol 5% 3 hrs, larvae L3    300 Ethanol 10% 3 hrs, larvae L3    273 Caffeine 1.5 mg/ml 4 hrs, larvae L3    256 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    615 Caffeine 25 mg/ml 48 hrs, 4-day adult    1030 Paraquat 5 mM 48 hrs, 4-day adult    500 Paraquat 10 mM 48 hrs, 4-day adult    250 Rotenone 2 μg 12 hrs, larvae L3    261 Rotenone 8 μg 12 hrs, larvae L3    109 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (802) cold shock, 4-day adult  (715) heat shock, 4-day adult  (261) Cadmium 50 mM 6 hrs, larvae L3  (197) Cadmium 50 mM 12 hrs, larvae L3  (382) Cadmium 50 mM 48 hrs, 4-day adult  (398) Cadmium 100 mM 48 hrs, 4-day adult  (707) Copper 0.5 mM 12 hrs, larvae L3  (673) Copper 15 mM 48 hrs, 4-day adult  (810) Zinc 5 mM 12 hrs, larvae L3  (808) Zinc 4.5 mM 48 hrs, 4-day adult  (950) Ethanol 2.5% 3 hrs, larvae L3  (185) Ethanol 5% 3 hrs, larvae L3  (300) Ethanol 10% 3 hrs, larvae L3  (273) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (256) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (615) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1030) Paraquat 5 mM 48 hrs, 4-day adult  (500) Paraquat 10 mM 48 hrs, 4-day adult  (250) Rotenone 2 μg 12 hrs, larvae L3  (261) Rotenone 8 μg 12 hrs, larvae L3  (109) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (802) cold shock, 4-day adult  (715) heat shock, 4-day adult  (261) Cadmium 50 mM 6 hrs, larvae L3  (197) Cadmium 50 mM 12 hrs, larvae L3  (382) Cadmium 50 mM 48 hrs, 4-day adult  (398) Cadmium 100 mM 48 hrs, 4-day adult  (707) Copper 0.5 mM 12 hrs, larvae L3  (673) Copper 15 mM 48 hrs, 4-day adult  (810) Zinc 5 mM 12 hrs, larvae L3  (808) Zinc 4.5 mM 48 hrs, 4-day adult  (950) Ethanol 2.5% 3 hrs, larvae L3  (185) Ethanol 5% 3 hrs, larvae L3  (300) Ethanol 10% 3 hrs, larvae L3  (273) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (256) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (615) Caffeine 25 mg/ml 48 hrs, 4-day adult  (1030) Paraquat 5 mM 48 hrs, 4-day adult  (500) Paraquat 10 mM 48 hrs, 4-day adult  (250) Rotenone 2 μg 12 hrs, larvae L3  (261) Rotenone 8 μg 12 hrs, larvae L3  109 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    802 cold shock, 4-day adult    715 heat shock, 4-day adult    261 Cadmium 50 mM 6 hrs, larvae L3    197 Cadmium 50 mM 12 hrs, larvae L3    382 Cadmium 50 mM 48 hrs, 4-day adult    398 Cadmium 100 mM 48 hrs, 4-day adult    707 Copper 0.5 mM 12 hrs, larvae L3    673 Copper 15 mM 48 hrs, 4-day adult    810 Zinc 5 mM 12 hrs, larvae L3    808 Zinc 4.5 mM 48 hrs, 4-day adult    950 Ethanol 2.5% 3 hrs, larvae L3    185 Ethanol 5% 3 hrs, larvae L3    300 Ethanol 10% 3 hrs, larvae L3    273 Caffeine 1.5 mg/ml 4 hrs, larvae L3    256 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    615 Caffeine 25 mg/ml 48 hrs, 4-day adult    1030 Paraquat 5 mM 48 hrs, 4-day adult    500 Paraquat 10 mM 48 hrs, 4-day adult    250 Rotenone 2 μg 12 hrs, larvae L3    261 Rotenone 8 μg 12 hrs, larvae L3    109 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_05 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • GH20776 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014020 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8416-RB;CG8416-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Rho1 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4dpp.blk1 Rho1Scer\UAS.cMa lethal, with Scer\GAL4elav.PLu Rho1N19.Scer\UAS Rho1V14.Scer\UAS lethal, with Scer\GAL4ey-OK107 Rho1V14.Scer\UAS lethal (with Df(2R)Jp8) Rho112-6 lethal (with Rho112-6) Rho1E3.10 Rho1J3.8 lethal (with Rho1E3.10) Rho112-6 lethal (with Rho1J3.8) Rho112-6 lethal | embryonic stage Rho1E3.10 Rho1k02107b lethal | embryonic stage, with Scer\GAL4en-e16E Rho1N19.Scer\UAS lethal | embryonic stage, with Scer\GAL4prd.RG1 Rho1N19.Scer\UAS lethal | embryonic stage, with Scer\GAL4repo Rho1N19.Scer\UAS lethal | embryonic stage | maternal effect | recessive Rho1rev220 lethal | embryonic stage | recessive Rho172O Rho1E3.10 Rho1Ebr233 Rho1Ebr246 Rho1J3.8 Rho1k02107b Rho1k07236 Rho1rev220 lethal | pharate adult stage, with Scer\GAL4ppl.PP Rho1GD4726 lethal | pupal stage, with Scer\GAL4pnr-MD237 Rho1GD4726 lethal | recessive Rho112-6 Rho1E3.10 Rho1J3.8 Rho1k02107b Rho1k07236 Rho1k07903 Other Phenotypes Allele cell migration defective | embryonic stage 10, with Scer\GAL4nos.UTR.T:Hsim\VP16 Rho1N19.Scer\UAS cell shape defective Rho1rev220 cell shape defective, with Scer\GAL4MtnA.PU Rho1V14.Scer\UAS cell shape defective | conditional | third instar larval stage, with Scer\GAL4ap-md544, Scer\GAL80ts.αTub84B Rho1GD4726 Rho1V14.Scer\UAS chemical resistant, with Scer\GAL4RhoGAP18B-NP1514 Rho1CA.Scer\UAS cytokinesis defective Rho172O Rho1dsRNA.75-821 cytokinesis defective, with Scer\GAL4neur-P72 Rho1N19.Scer\UAS cytokinesis defective, with Scer\GAL4twi.PB Rho1N19.Scer\UAS cytokinesis defective | embryonic stage | recessive Rho172O cytokinesis defective | recessive Rho172R increased cell death, with Scer\GAL4dpp.blk1 Rho1N19.Scer\UAS Rho1Scer\UAS.cMa increased cell death, with Scer\GAL4ptc-559.1 Rho1Scer\UAS.cMa mitotic cell cycle defective, with Scer\GAL4prd.RG1 Rho1N19.Scer\UAS mitotic cell cycle defective | recessive Rho172O Rho172R neuroanatomy defective, with Scer\GAL4Appl.G1a Rho1V14.Scer\UAS neuroanatomy defective, with Scer\GAL4ey-OK107 Rho1V14.E40L.Scer\UAS Rho1V14.Scer\UAS neuroanatomy defective, with Scer\GAL4GMR.PF Rho1Scer\UAS.T:Myr-Src64B Rho1V14.Scer\UAS neuroanatomy defective | embryonic stage 16, with Scer\GAL4ftz.ng Rho1V14.Scer\UAS neuroanatomy defective | embryonic stage, with Scer\GAL4repo Rho1V14.Scer\UAS neuroanatomy defective | recessive | somatic clone Rho172O non-enhancer of variegation, with In(1)wm4h Rho172O non-suppressor of variegation, with In(1)wm4h Rho172O phototaxis defective, with Scer\GAL4Appl.G1a Rho1V14.Scer\UAS planar polarity defective Rho1V14.sev planar polarity defective, with Scer\GAL4dpp.blk1 Rho1N19.Scer\UAS planar polarity defective, with Scer\GAL4hs.2sev Rho1Scer\UAS.cMa Rho1V14.F39V.Scer\UAS Rho1V14.Scer\UAS planar polarity defective | recessive | somatic clone Rho172BH Rho172M1 planar polarity defective | somatic clone Rho172M1 Rho1N19.sev Rho1V14.sev visible Rho1GMR.PH Rho1V14.sev visible, with Scer\GAL4dpp.blk1 Rho1Scer\UAS.cMa visible, with Scer\GAL4ppl.PP Rho1GD4726 visible | heat sensitive, with Scer\GAL4ptc-559.1, Scer\GAL80ts.αTub84B Rho1GD4726 visible | recessive Rho1k07236 wound healing defective (with Rho172O) Rho172R wound healing defective (with Rho172R) Rho172O Phenotype manifest in Allele actin cytoskeleton | blastoderm stage | germline clone Rho1L3 actin filament & embryonic/larval tracheal system, with Scer\GAL4btl.PS Rho1GD4726 actomyosin contractile ring Rho1dsRNA.75-821 adherens junction | pupal stage, with Scer\GAL4GMR.PF Rho1dsRNA.1.Scer\UAS adherens junction | somatic clone Rho172F Rho172O adherens junction | somatic clone, with Scer\GAL4Act5C.PI Rho1dsRNA.1.Scer\UAS adult abdomen | dorsal, with Scer\GAL4ppl.PP Rho1GD4726 adult cuticle | dorsal, with Scer\GAL4ppl.PP Rho1GD4726 amnioproctodeal invagination, with Scer\GAL4nos.PG Rho1N19.Scer\UAS anterior embryonic/larval midgut, with Scer\GAL4Gap1-NP3392 Rho1V14.Scer\UAS anterior midgut primordium, with Scer\GAL4twi.PG Rho1N19.Scer\UAS blastoderm embryo | germline clone Rho1L3 Bolwig nerve, with Scer\GAL4GMR.PF Rho1V12.Scer\UAS border follicle cell, with Scer\GAL4slbo.2.6 Rho1N19.Scer\UAS Rho1V14.Scer\UAS circular visceral muscle primordium Rho11B cortical actin cytoskeleton & embryonic posterior spiracle, with Scer\GAL4ems.HRE Rho1N19.Scer\UAS cortical actin cytoskeleton & spiracular chamber (with Rho11B) Rho172R cortical actin cytoskeleton & spiracular chamber (with Rho172R) Rho11B cortical actin cytoskeleton & syncytial blastoderm embryo | maternal effect Rho1L3 denticle belt | maternal effect Rho1rev220 disc epithelium proper & dorsal mesothoracic disc, with Scer\GAL4ptc-559.1 Rho1Scer\UAS.cMa dorsal closure embryo Rho172O Rho172R Rho1rev220 dorsal closure embryo, with Scer\GAL4en-e16E Rho1N19.Scer\UAS dorsal closure embryo, with Scer\GAL4LE Rho1N19.Scer\UAS dorsal closure embryo, with Scer\GAL4pnr-MD237 Rho1N19.Scer\UAS Rho1V12.Scer\UAS dorsal closure embryo, with Scer\GAL4prd.RG1 Rho1N19.Scer\UAS dorsal trunk primordium, with Scer\GAL4btl.PS Rho1N19.Scer\UAS Rho1V14.Scer\UAS embryo Rho172O Rho172R embryonic/first instar larval cuticle Rho172O embryonic/first instar larval cuticle, with Scer\GAL4en-e16E Rho1N19.Scer\UAS embryonic/first instar larval cuticle, with Scer\GAL4mat.αTub67C.T:Hsim\VP16 Rho1N19.Scer\UAS embryonic/first instar larval cuticle, with Scer\GAL4prd.RG1 Rho1N19.Scer\UAS embryonic/first instar larval cuticle, with Scer\GAL4twi.PG Rho1N19.Scer\UAS embryonic/first instar larval cuticle & embryonic head Rho1rev220 embryonic/first instar larval cuticle | anterior Rho1Ebr233 Rho1Ebr246 embryonic/first instar larval cuticle | anterior | dorsal Rho1E3.10 Rho1J3.8 embryonic/first instar larval cuticle | anterior | dorsal (with Df(2R)Jp8) Rho1E3.10 embryonic/first instar larval cuticle | anterior | dorsal (with Rho172O) Rho1E3.10 embryonic/first instar larval cuticle | anterior | dorsal (with Rho1E3.10) Rho172O Rho1J3.8 embryonic/first instar larval cuticle | anterior | dorsal (with Rho1J3.8) Rho1E3.10 embryonic/first instar larval cuticle | dorsal, with Scer\GAL4hs.PB Rho1N19.Scer\UAS embryonic/larval cuticle Rho172O embryonic/larval dorsal anastomosis, with Scer\GAL4btl.PS Rho1V14.Scer\UAS embryonic/larval dorsal trunk (with Rho172F) Rho172O embryonic/larval dorsal trunk (with Rho172O) Rho172F embryonic/larval hemolymph | third instar larval stage, with Scer\GAL4He.PZ Rho1V14.Scer\UAS embryonic/larval hindgut, with Scer\GAL4NP2432 Rho1N19.Scer\UAS embryonic/larval midgut primordium, with Scer\GAL4NP2432 Rho1N19.Scer\UAS embryonic/larval posterior spiracle Rho1E3.10 embryonic/larval posterior spiracle (with Rho172O) Rho1E3.10 embryonic/larval posterior spiracle (with Rho1E3.10) Rho172O embryonic/larval trachea Rho172F embryonic dorsal epidermis Rho172F Rho172O Rho172R embryonic dorsal epidermis | anterior Rho172F Rho172O Rho172R embryonic epidermis, with Scer\GAL4en-e16E Rho1N19.Scer\UAS embryonic epidermis, with Scer\GAL4prd.RG1 Rho1N19.Scer\UAS embryonic epidermis | dorsal Rho172O Rho172R embryonic epidermis | dorsal, with Scer\GAL4LE Rho1N19.Scer\UAS embryonic epidermis | dorsal | maternal effect Rho1rev220 embryonic epidermis | maternal effect Rho1rev220 embryonic head Rho172O Rho1rev220 embryonic head (with Rho172O) Rho172R embryonic head (with Rho172R) Rho172O embryonic head | maternal effect Rho1rev220 embryonic hemocyte Rho11B embryonic hemocyte, with Scer\GAL4Pxn.PS, Scer\GAL4crq.PA Rho1N19.Scer\UAS embryonic hindgut, with Scer\GAL4NP2432 Rho1N19.Scer\UAS embryonic leading edge cell Rho172O embryonic leading edge cell, with Scer\GAL4en-e16E Rho1N19.Scer\UAS Rho1V14.Scer\UAS embryonic leading edge cell, with Scer\GAL4prd.RG1 Rho1N19.Scer\UAS embryonic leading edge cell (with Rho172O) Rho172R embryonic leading edge cell (with Rho172R) Rho172O embryonic Malpighian tubule tip cell, with Scer\GAL4ct.CtB Rho1N19.Scer\UAS embryonic segment Rho1unspecified epithelial cell | pupal stage, with Scer\GAL4GMR.PF Rho1dsRNA.1.Scer\UAS extended germ band embryo Rho1Ebr233 Rho1Ebr246 extended germ band embryo, with Scer\GAL4c381 Rho1N19.Scer\UAS Rho1V12.Scer\UAS extended germ band embryo, with Scer\GAL4Kr.PM Rho1N19.Scer\UAS Rho1V12.Scer\UAS external sensory organ precursor cell, with Scer\GAL4neur-P72 Rho1N19.Scer\UAS eye Rho1GMR.PH Rho1V14.sev Rho1k07236 eye, with Scer\GAL4GMR.PF Rho1V14.Scer\UAS Rho1Scer\UAS.T:Myr-Src64B eye, with Scer\GAL4hs.2sev Rho1V14.E40L.Scer\UAS eye | pupal stage, with Scer\GAL4GMR.PF Rho1dsRNA.1.Scer\UAS eye disc & photoreceptor cell & axon, with Scer\GAL4GMR.PF Rho1V12.Scer\UAS eye disc & subretinal glial cell, with Scer\GAL4GMR.PF Rho1V12.Scer\UAS eye photoreceptor cell, with Scer\GAL4hs.2sev Rho1V14.E40L.Scer\UAS eye photoreceptor cell | somatic clone Rho172M1 Rho1V14.sev eye photoreceptor cell | third instar larval stage, with Scer\GAL4GMR.PF Rho1N19.Scer\UAS filopodium, with Scer\GAL4en-e16E Rho1N19.Scer\UAS Rho1V14.Scer\UAS filopodium (with Rho172O) Rho172R filopodium (with Rho172R) Rho172O filzkorper Rho11B Rho1E3.10 filzkorper, with Scer\GAL4ems.HRE Rho1N19.Scer\UAS Rho1V14.Scer\UAS germline cell | ectopic | embryonic stage | maternal effect, with Scer\GAL4nos.UTR.T:Hsim\VP16 Rho1N19.Scer\UAS Rho1V14.Scer\UAS germline cell | embryonic stage, with Scer\GAL4nos.UTR.T:Hsim\VP16 Rho1N19.Scer\UAS head Rho172F Rho172O Rho172R hub cell | somatic clone, with Scer\GAL4Act5C.PI Rho1dsRNA.1.Scer\UAS imaginal disc | third instar larval stage, with Scer\GAL4dpp.blk1 Rho1N19.Scer\UAS interommatidial bristle Rho1GMR.PH lamina | third instar larval stage, with Scer\GAL4GMR.PF Rho1N19.Scer\UAS lateral trunk primordium, with Scer\GAL4btl.PS Rho1V14.Scer\UAS mesectoderm, with Scer\GAL4en-e16E Rho1N19.Scer\UAS mesoderm, with Scer\GAL4twi.PG Rho1N19.Scer\UAS midline crossing tract | embryonic stage 16, with Scer\GAL4ftz.ng Rho1V14.Scer\UAS mitotic telophase Rho1dsRNA.75-821 mitotic telophase & spindle Rho1dsRNA.75-821 morphogenetic furrow | somatic clone Rho172M1 mushroom body, with Scer\GAL4ey-OK107 Rho1V14.Scer\UAS Rho1dsRNA.Scer\UAS mushroom body & dendrite, with Scer\GAL4Tab2-201Y Rho1V14.Scer\UAS mushroom body & dendrite | somatic clone Rho172O Rho172R mushroom body & dendrite | somatic clone, with Scer\GAL4Tab2-201Y Rho1V14.Scer\UAS mushroom body & neuron | somatic clone Rho172O Rho172R mushroom body | somatic clone Rho172O mushroom body vertical lobe, with Scer\GAL4ey-OK107 Rho1V14.E40L.Scer\UAS nurse cell ring canal | maternal effect Rho1rev220 ommatidial precursor cluster | somatic clone Rho172R ommatidium Rho1GMR.PH Rho1V14.sev ommatidium, with Scer\GAL4GMR.PF Rho1Scer\UAS.cMa ommatidium, with Scer\GAL4hs.2sev Rho1Scer\UAS.cMa Rho1V14.F39V.Scer\UAS Rho1V14.Scer\UAS ommatidium | somatic clone Rho172M1 Rho1V14.sev oocyte | maternal effect Rho1rev220 peripheral glial cell Rho1E3.10 Rho1k02107b peripheral glial cell, with Scer\GAL4repo Rho1N19.Scer\UAS Rho1V14.Scer\UAS peripheral glial cell | embryonic stage, with Scer\GAL4repo Rho1V14.Scer\UAS photoreceptor cell Rho1GMR.PH Rho1V14.sev photoreceptor cell, with Scer\GAL4GMR.PF Rho1Scer\UAS.cMa photoreceptor cell, with Scer\GAL4hs.2sev Rho1V14.F39V.Scer\UAS Rho1V14.Scer\UAS pigment cell Rho1GMR.PH posterior spiracle primordium, with Scer\GAL4ems.HRE Rho1N19.Scer\UAS Rho1V14.Scer\UAS presumptive embryonic/larval muscle system, with Scer\GAL4how-24B Rho1N19.Scer\UAS presumptive embryonic/larval tracheal system Rho172R presumptive embryonic/larval tracheal system, with Scer\GAL4btl.PS Rho1V14.Scer\UAS presumptive embryonic salivary gland Rho11B Rho1k02107b presumptive embryonic salivary gland, with Scer\GAL4en-e16E Rho1N19.Scer\UAS presumptive embryonic salivary gland, with Scer\GAL4fkh.PH Rho1N19.Scer\UAS Rho1V12.Scer\UAS presumptive embryonic salivary gland, with Scer\GAL4twi.PB Rho1N19.Scer\UAS presumptive embryonic salivary gland (with Df(2R)Jp1) Rho1k02107b primordium of embryonic/larval spiracle, with Scer\GAL4ems.HRE Rho1N19.Scer\UAS Rho1V14.Scer\UAS retina Rho1GMR.PH retina, with Scer\GAL4GMR.PF Rho1V14.Scer\UAS Rho1Scer\UAS.T:Myr-Src64B rhabdomere Rho1GMR.PH RP3 motor neuron Rho1rev220 secondary pigment cell Rho1GMR.PH sensory neuron & axon, with Scer\GAL4repo Rho1V14.Scer\UAS stomodeal invagination, with Scer\GAL4nos.PG Rho1N19.Scer\UAS tertiary pigment cell Rho1GMR.PH tracheal primordium Rho172R vacuole, with Scer\GAL4Appl.G1a Rho1V14.Scer\UAS vacuole, with Scer\GAL4GMR.PF Rho1Scer\UAS.T:Myr-Src64B ventral furrow, with Scer\GAL4nos.PG Rho1N19.Scer\UAS ventral longitudinal muscle, with Scer\GAL4how-24B Rho1N19.Scer\UAS ventral nerve cord commissure | embryonic stage 16, with Scer\GAL4ftz.ng Rho1V14.Scer\UAS wing | heat sensitive, with Scer\GAL4ptc-559.1, Scer\GAL80ts.αTub84B Rho1N19.Scer\UAS Rho1V14.Scer\UAS Rho1GD4726 wing | somatic clone Rho1unspecified wing | somatic clone, with Scer\GAL4Act.PU Rho1N19.Scer\UAS Rho1V14.Scer\UAS wing blade, with Scer\GAL4dpp.blk1 Rho1Scer\UAS.cMa wing disc, with Scer\GAL4Bx-MS1096 Rho1Scer\UAS.cMa wing disc, with Scer\GAL4ptc-559.1 Rho1Scer\UAS.cMa wing disc | conditional | third instar larval stage, with Scer\GAL4ap-md544, Scer\GAL80ts.αTub84B Rho1V14.Scer\UAS Rho1GD4726 wing disc | third instar larval stage, with Scer\GAL4dpp.blk1 Rho1Scer\UAS.cMa wing hair, with Scer\GAL4dpp.blk1 Rho1N19.Scer\UAS wing hair | heat sensitive, with Scer\GAL4ptc-559.1, Scer\GAL80ts.αTub84B Rho1N19.Scer\UAS Rho1GD4726 wing hair | somatic clone Rho172BH wing hair | somatic clone | supernumerary Rho1unspecified wing hair | somatic clone | supernumerary, with Scer\GAL4Act.PU Rho1V14.Scer\UAS wing hair | supernumerary | heat sensitive, with Scer\GAL4ptc-559.1, Scer\GAL80ts.αTub84B Rho1N19.Scer\UAS Rho1V14.Scer\UAS Rho1GD4726
Classical Alleles ( 34 )
For All Classical Alleles Show
Allele of Rho1 Class Mutagen Stocks Known lesion Rho1E3.10 loss of function allele 2 Yes Rho1KG01774 2 -- Rho11B loss of function allele P-element activity 1 Yes Rho172F P-element activity 1 Yes Rho172O P-element activity 1 Yes Rho1BH 1 -- Rho1c00122 piggyBac transposase 1 -- Rho1c00252 piggyBac transposase 1 -- Rho1CB-6645-3 1 -- Rho1d02325 P-element activity 1 -- Rho1k02107b P-element activity 1 Yes Rho1NP0324 1 -- Rho112-6 ethyl methanesulfonate 0 -- Rho172BH hypomorphic allele - genetic evidence P-element activity 0 Yes Rho172M1 hypomorphic allele - genetic evidence P-element activity 0 Yes Rho172R loss of function allele, hypomorphic allele - genetic evidence P-element activity 0 Yes Rho179-3 0 -- Rho1c00263 piggyBac transposase 0 -- Rho1c00282 piggyBac transposase 0 -- Rho1c00763 piggyBac transposase 0 -- Rho1d07224 P-element activity 0 -- Rho1d07511 P-element activity 0 -- Rho1Df236 0 -- Rho1Df903 0 -- Rho1E.10 0 -- Rho1Ebr233 ethyl methanesulfonate 0 -- Rho1Ebr246 ethyl methanesulfonate 0 -- Rho1J3.8 0 Yes Rho1k02107rev5 P-element activity 0 Yes Rho1k07236 P-element activity 0 Yes Rho1k07903 P-element activity 0 Yes Rho1L3 P-element activity 0 Yes Rho1rev220 0 Yes Rho1unspecified 0 --
Alleles Carried on Transgenic Constructs ( 36 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Rho1 Class Mutagen Stocks Known lesion Rho1T:Avic\GFP in vitro construct - coding region fusion 3 Yes Rho1dsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 2 Yes Rho1N19.Scer\UAS in vitro construct - regulatory fusion 2 Yes Rho1Scer\UAS.P\T.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes Rho1Scer\UAS.P\T.T:Uuuu\T7 in vitro construct - regulatory fusion in vitro construct - coding region fusion 2 Yes Rho1V14.E40L.Scer\UAS in vitro construct - amino acid replacement in vitro construct - regulatory fusion 2 Yes Rho1V14.Scer\UAS in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 2 Yes Rho1D100N.Scer\UAS.P\T.T:Uuuu\T7 in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis 1 Yes Rho1dsRNA.1.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes Rho1dsRNA.2.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 1 Yes Rho1GD4726 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rho1HMS00375 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rho1JF02809 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Rho1Scer\UAS.cMa in vitro construct - regulatory fusion 1 Yes Rho1Scer\UAS.cWa in vitro construct - regulatory fusion 1 Yes Rho1V14.F39V.Scer\UAS in vitro construct - amino acid replacement in vitro construct - regulatory fusion 1 Yes Rho1+mMa in vitro construct - minigene 0 Yes Rho1Act5C.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Rho1C189S.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes Rho1CA.Scer\UAS in vitro construct - regulatory fusion 0 Yes Rho1dsRNA.75-821 in vitro construct - RNAi 0 Yes Rho1dsRNA.cCa in vitro construct - RNAi 0 Yes Rho1dsRNA.cHa in vitro construct - RNAi 0 Yes Rho1dsRNA.cMa in vitro construct - RNAi 0 Yes Rho1dsRNA.cMb in vitro construct - RNAi 0 Yes Rho1dsRNA.cRa in vitro construct - RNAi 0 Yes Rho1dsRNA.cSa in vitro construct - RNAi 0 Yes Rho1GMR.PH in vitro construct - minigene in vitro construct - regulatory fusion 0 Yes Rho1KK108182 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Rho1N19.sev in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 -- Rho1Scer\UAS.cHa in vitro construct - regulatory fusion 0 Yes Rho1Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Rho1Scer\UAS.T:Myr-Src64B in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Rho1Scer\UAS:T:Avic\GFP-CFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Rho1V12.Scer\UAS in vitro construct - regulatory fusion 0 Yes Rho1V14.sev in vitro construct - regulatory fusion 0 --
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7139 (Ryder, 2004.4.26) Df(2R)Jp4 (Halsell et al., 2000) Df(2R)Jp6 (BDGP Project Members, 1994-1999, Sasamura et al., 1997, Rothenfluh et al., 2006) Df(2R)Jp8 (Halsell and Kiehart, 1998, Prokopenko et al., 1999, Halsell et al., 2000, Ward et al., 2003, Bayer et al., 2003, BDGP Project Members, 1994-1999) Df(2R)Np3 (BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)44CE (BDGP Project Members, 1994-1999) Df(2R)Dg248 (Mirouse et al., 2009, Mirouse et al., 2009) Df(2R)Dg323 (Mirouse et al., 2009, Mirouse et al., 2009) Df(2R)Jp1 (Spradling et al., 1999, Halsell et al., 2000, BDGP Project Members, 1994-1999) Df(2R)KL32 (BDGP Project Members, 1994-1999, Sasamura et al., 1997) Df(2R)WMG (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4726} NA P{KK108182} NA P{TRiP.HMS00375} NA P{TRiP.JF02809} NA P{UAS-myr-Rho1} NA P{UAS-Rho1.325-786.dsRNA} NA P{UAS-Rho1.770-1310.dsRNA} NA P{UAS-Rho1.C189S} NA P{UAS-Rho1.CA} NA P{UAS-Rho1.CFP} NA P{UAS-Rho1.G14V} NA P{UAS-Rho1.GFP} NA P{UAS-Rho1.L} NA P{UAS-Rho1.N19} NA P{UAS-Rho1.Sph} NA P{UAS-Rho1.V12} NA P{UAS-Rho1.V14.E40L} NA P{UAS-Rho1.V14.F39V} NA P{UAS-Rho1.V14} NA P{UAS-Rho1.W} NA P{UAS-Rho1-dsRNA} NA heat-shock construct P{sE-Rho1.V14} NA characterization construct P{GMR-Rho1} NA P{Rho1+mMa} NA P{sE-Rho1.N19} NA P{UAS-Rho1.EGFP} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}l(2)SH0145SH0145 No P{lacW}Rho1k02107b No P{lacW}Rho1k07236 No P{lacW}Rho1k07903 No insertion of enhancer trap binary system P{GawB}Rho1NP0324 No PBac{GAL4D,EYFP}Rho1L3 No miscellaneous insertions P{RS3}Rho1CB-6645-3 NA P{SUPor-P}Rho1KG01774 NA P{wHy}Syn2DG09306 NA PBac{PB}Rho1c00122 NA PBac{PB}Rho1c00252 NA PBac{PB}Rho1c00263 NA PBac{PB}Rho1c00282 NA PBac{PB}Rho1c00763 NA insertion of mobile activating element P{GSV1}GSd231GSd231 NA P{GSV1}GSd431GSd431 NA P{XP}Rho1d02325 NA P{XP}Rho1d07224 NA P{XP}Rho1d07511 NA
Gene Ontology: Function, Process & Cellular Component ( 64 unique terms )
Terms Based on Experimental Evidence ( 50 terms )
Molecular Function
CV term Evidence References
kinase binding inferred from physical interaction with rok (Winter et al., 2001) protein binding inferred from physical interaction with rok (Mizuno et al., 1999) inferred from physical interaction with wash (Liu et al., 2009) inferred from physical interaction with UniProtKB:A1Z7T0 (assigned by UniProtKB) (Betson and Settleman, 2007)
Biological Process
CV term Evidence References
actin cytoskeleton organization inferred from mutant phenotype (Padash Barmchi et al., 2005) actin filament bundle assembly inferred from mutant phenotype (Wood et al., 2002) actin filament organization inferred from mutant phenotype (Kiger et al., 2003, Yan et al., 2009) axon guidance inferred from mutant phenotype (Fritz and VanBerkum, 2002) border follicle cell migration inferred from mutant phenotype (Bastock and Strutt, 2007) cell elongation involved in imaginal disc-derived wing morphogenesis inferred from mutant phenotype (Widmann and Dahmann, 2009) cellularization inferred from mutant phenotype (Padash Barmchi et al., 2005) compound eye morphogenesis inferred from genetic interaction with p120ctn (Larson et al., 2008) cortical actin cytoskeleton organization inferred from mutant phenotype (Jean et al., 2012) cytokinesis inferred from mutant phenotype (Somma et al., 2002, Kiger et al., 2003, Echard et al., 2004, Eggert et al., 2004, Dean et al., 2005) dendrite self-avoidance inferred from genetic interaction with stan (Matsubara et al., 2011) determination of left/right symmetry inferred from mutant phenotype (Taniguchi et al., 2007) dorsal closure inferred from mutant phenotype (Bloor and Kiehart, 2002) NOT dorsal closure, amnioserosa morphology change inferred from mutant phenotype (Harden et al., 2002) dorsal closure, leading edge cell differentiation inferred from mutant phenotype (Jacinto et al., 2002) dorsal closure, spreading of leading edge cells inferred from mutant phenotype (Jacinto et al., 2002) endocytosis inferred from mutant phenotype (Magie and Parkhurst, 2005) epidermal growth factor receptor signaling pathway inferred from genetic interaction with cv-c (Brodu and Casanova, 2006) establishment of protein localization inferred from mutant phenotype (Dean et al., 2005) gastrulation involving germ band extension inferred from mutant phenotype (Barrett et al., 1997) germ-band extension inferred from mutant phenotype (Barrett et al., 1997) glial cell migration inferred from mutant phenotype (Sepp and Auld, 2003) hemocyte migration inferred from mutant phenotype (Stramer et al., 2005) imaginal disc-derived wing hair organization inferred from genetic interaction with fz (Winter et al., 2001) inferred from mutant phenotype (Yan et al., 2009) lumen formation, open tracheal system inferred from mutant phenotype (Lee and Kolodziej, 2002) maintenance of epithelial cell apical/basal polarity inferred from mutant phenotype (Xu et al., 2008) melanization defense response inferred from mutant phenotype (Bidla et al., 2007) motor neuron axon guidance inferred from mutant phenotype (Dorsten et al., 2007) NOT muscle attachment inferred from mutant phenotype (Bloor and Kiehart, 2001) NOT myofibril assembly inferred from mutant phenotype (Bloor and Kiehart, 2001) neuroblast proliferation inferred from mutant phenotype (Lee et al., 2000) open tracheal system development inferred from mutant phenotype (Matusek et al., 2006, Lovegrove et al., 2006) peripheral nervous system development inferred from mutant phenotype (Sepp and Auld, 2003, Sepp and Auld, 2003) posterior midgut invagination inferred from mutant phenotype (Barrett et al., 1997) pseudocleavage involved in syncytial blastoderm formation inferred from mutant phenotype (Webb et al., 2009) regulation of axonogenesis inferred from genetic interaction with LIMK1 (Ng and Luo, 2004) regulation of cytoskeleton organization inferred from direct assay (Liu et al., 2009) regulation of embryonic cell shape inferred from mutant phenotype (Xu et al., 2008) regulation of Malpighian tubule size inferred from mutant phenotype (Denholm et al., 2005) regulation of tube length, open tracheal system inferred from mutant phenotype (Chung et al., 2009) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009) salivary gland morphogenesis inferred from mutant phenotype (Xu et al., 2008) spiracle morphogenesis, open tracheal system inferred from mutant phenotype (Simoes et al., 2006) ventral furrow formation inferred from mutant phenotype (Barrett et al., 1997) wound healing inferred from mutant phenotype (Wood et al., 2002, Campos et al., 2010)
Cellular Component
CV term Evidence References
cell cortex inferred from direct assay (Rosales-Nieves et al., 2006) cell hair inferred from direct assay (Yan et al., 2009) cytoplasm inferred from direct assay (Yan et al., 2009)
Terms Based on Predictions or Assertions ( 19 terms )
Molecular Function
CV term Evidence References
GTPase activity inferred from sequence or structural similarity (Jekely, 2003) inferred from sequence or structural similarity with EMBL:AF014371 (FlyBase, 1992-) non-traceable author statement (Noselli and Agnes, 1999, Swiss-Prot Project Members, 1996.2.1) traceable author statement (Newsome et al., 2000) GTP binding inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR003578, InterPro:IPR005225 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
actin cytoskeleton organization traceable author statement (Johnstone and Lasko, 2001) branch fusion, open tracheal system traceable author statement (Starz-Gaiano and Montell, 2004) cellularization traceable author statement (Mazumdar and Mazumdar, 2002) cytoskeleton organization traceable author statement (Van Aelst and Symons, 2002) dendrite morphogenesis traceable author statement (Gao and Bogert, 2003) dorsal closure traceable author statement (Noselli and Agnes, 1999, Van Aelst and Symons, 2002, Harden, 2002) establishment of imaginal disc-derived wing hair orientation traceable author statement (Noselli and Agnes, 1999) establishment of planar polarity non-traceable author statement (Mlodzik, 2002) traceable author statement (Tree et al., 2002) establishment of tissue polarity non-traceable author statement (Van Aelst and Symons, 2002) gastrulation non-traceable author statement (Leptin, 1999) germ cell migration traceable author statement (Starz-Gaiano and Montell, 2004) JNK cascade non-traceable author statement (Noselli and Agnes, 1999) lumen formation, open tracheal system traceable author statement (Ghabrial et al., 2003) motor neuron axon guidance non-traceable author statement (Patel and Van Vactor, 2002) ommatidial rotation non-traceable author statement (Van Aelst and Symons, 2002) traceable author statement (Noselli and Agnes, 1999) small GTPase mediated signal transduction inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR003578 (FlyBase Curators et al., 2004-) Wnt receptor signaling pathway non-traceable author statement (Wedlich, 2002)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Rho1 - B52 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - CG10077 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - CG13321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - CG14786 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - CG16940 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - CG4611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - CG4612 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - CG4849 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - CG5746 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - CG6701 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - CG6937 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - CG7878 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - CG9775 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - Cdc5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - Dp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - Dph5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - Imp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - Rab6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - RhoGDI anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Rho1 - Saf-B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - Upf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - Zn72D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - btz anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - cathD anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - coil anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - cora anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - eIF4AIII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - mRpL15 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - mRpL44 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - mRpL9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - mTerf3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - mod anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - mwh anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation (Yan et al., 2009) Rho1 - nito anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - pbl two hybrid (Prokopenko et al., 1999) Rho1 - qkr58E-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Rho1 - rok two hybrid (Mizuno et al., 1999) Rho1 - snRNP-U1-70K anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Rho1 allele Gene References Rho112-6 E(zip)12-5 (Bayer et al., 2003) E(zip)18-5 (Bayer et al., 2003) E(zip)31-6 (Bayer et al., 2003) RhoGEF2 (Bayer et al., 2003) rok (Bayer et al., 2003) Sb (Bayer et al., 2003) zip (Bayer et al., 2003) Rho172BH zip (Mizuno et al., 2002) Rho172F Sb (Bayer et al., 2003) zip (Halsell et al., 2000) Rho172O br (Chen et al., 2004) CycE (Brumby et al., 2004) fz (Winter et al., 2001) LIMK1 (Chen et al., 2004, Ng and Luo, 2004) Pak (Ng and Luo, 2004) pbl (Echard and O'Farrell, 2003) Rac1 (Tan et al., 2003) Sb (Bayer et al., 2003, Chen et al., 2004) ssh (Ng and Luo, 2004) zip (Halsell et al., 2000, Mizuno et al., 2002) Rho172R btl (Zhu et al., 2005) CycE (Brumby et al., 2004) LIMK1 (Ng and Luo, 2004) Moe (Speck et al., 2003) pbl (Prokopenko et al., 1999, Shandala et al., 2004) Pkn (Lu and Settleman, 1999) Rac1 (Fanto et al., 2000) Rho1dsRNA.cRa RhoGEF2 (Rogers et al., 2004) Rho1E3.10 br (Ward et al., 2003, Bayer et al., 2003) E(br)24 (Ward et al., 2003) E(br)121 (Ward et al., 2003) E(zip)12-5 (Bayer et al., 2003) E(zip)18-5 (Bayer et al., 2003) E(zip)31-6 (Bayer et al., 2003) flw (Vereshchagina et al., 2004) Moe (Speck et al., 2003) RhoGEF2 (Bayer et al., 2003) rok (Bayer et al., 2003) Sb (Bayer et al., 2003) zip (Halsell and Kiehart, 1998, Halsell et al., 2000, Bayer et al., 2003) Rho1Ebr233 br (Ward et al., 2003) RhoGEF2 (Ward et al., 2003) zip (Ward et al., 2003) Rho1Ebr246 br (Ward et al., 2003) RhoGEF2 (Ward et al., 2003) zip (Ward et al., 2003) Rho1GMR.PH Cdc37 (Hariharan et al., 1995) dia (Prokopenko et al., 1999) Parp (Uchida et al., 2002) pbl (Prokopenko et al., 1999) RhoGEF2 (Barrett et al., 1997) Rho1J3.8 br (Ward et al., 2003, Bayer et al., 2003) E(br)65 (Ward et al., 2003) E(br)121 (Ward et al., 2003) E(br)155 (Ward et al., 2003) E(br)420 (Ward et al., 2003) E(br)444 (Ward et al., 2003) E(zip)12-5 (Bayer et al., 2003) E(zip)18-5 (Bayer et al., 2003) E(zip)31-6 (Bayer et al., 2003) peb (Wilk et al., 2004) RhoGEF2 (Bayer et al., 2003) rok (Bayer et al., 2003) Sb (Ward et al., 2003, Bayer et al., 2003) zip (Halsell and Kiehart, 1998, Halsell et al., 2000, Bayer et al., 2003) Rho1k02107b br (Ward et al., 2003, Chen et al., 2004) E(br)121 (Ward et al., 2003) E(br)444 (Ward et al., 2003) LIMK1 (Chen et al., 2004) Sb (Chen et al., 2004) Rho1k07236 plexB (Hu et al., 2001) Rho1k07903 dsh (Boutros et al., 1998) Rac1 (Fanto et al., 2000) Rho1N19.Scer\UAS BacA\p35 (Bloor and Kiehart, 2002) RhoGEF64C (Bashaw et al., 2001) robo (Fritz and VanBerkum, 2002) Sos (Fritz and VanBerkum, 2002) Rho1rev220 capu (Magie et al., 1999) cta (Magie et al., 1999) plexB (Hu et al., 2001) Rho1Scer\UAS.cMa LIMK1 (Ng and Luo, 2004) RhoGAPp190 (Billuart et al., 2001) rin (Pazman et al., 2000) Rho1V14.Scer\UAS robo (Fritz and VanBerkum, 2002) Sos (Fritz and VanBerkum, 2002) Rho1V14.sev dsh (Boutros et al., 1998) rin (Pazman et al., 2000) unspecified cv-c (Brodu and Casanova, 2006, Denholm et al., 2005) DAAM (Matusek et al., 2006) dsh (Strutt et al., 1997) fz (Strutt et al., 1997) grim (Mueller et al., 2005) H (Mueller et al., 2005) Moe (Molnar and de Celis, 2006) p53 (Mueller et al., 2005) RhoGEF64C (Simoes et al., 2006) rpr (Mueller et al., 2005) shg (Mirkovic and Mlodzik, 2006) tow (Chung et al., 2007) W (Mueller et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62500 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0014020 DroID - A comprehensive database of gene and protein interactions. • FBgn0014020 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36775
Orthologs
OrthoDB Orthologs (55) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG676KKM Dipteran inclusive ortholog search EOG6V6ZRS Insect inclusive ortholog search EOG60RZBW Arthropod inclusive ortholog search EOG6VX0NB Metazoa inclusive ortholog search EOG6PGJVH
Orthologs in Drosophila Species (EOG676KKM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Rho1     Drosophila simulans   Dsim\GD11158 Y   Drosophila sechellia   Dsec\GM21657 Y   Drosophila erecta   Dere\GG20566 Y   Drosophila yakuba   Dyak\GE11751 Y   Drosophila ananassae   Dana\GF11290 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA25121 Y   Drosophila persimilis   Dper\GL20555 Y   Drosophila willistoni   Dwil\GK23137 Y   Drosophila virilis   Dvir\GJ22286 Y   Drosophila mojavensis   Dmoj\GI19151 Y   Drosophila grimshawi   Dgri\GH22067 Y
Orthologs in non-Drosophila Dipterans (EOG6V6ZRS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013139   Anopheles gambiae Malaria mosquito  Agam\AGAP005160
Orthologs in non-Dipteran Insects (EOG60RZBW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB47431   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004945   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH14542   Atta cephalotes Leafcutter ant  Acep\ACEP10655   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18124   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL13502   Linepithema humile Argentine ant  Lhum\LH21923   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19884   Solenopsis invicta Red fire ant  Sinv\SINV26201   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003261   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001372   Pediculus humanus Human body louse  Phum\PHUM309390   Tribolium castaneum Red flour beetle  Tcas\Rho1
Orthologs in non-Insect Arthropods (EOG6VX0NB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_301996   Ixodes scapularis Deer tick  Isca\ISCW016777
Orthologs in non-Arthropod Metazoa (EOG6PGJVH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\rho-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_006573gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011029gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011030gn   Danio rerio Zebrafish  Drer\rhoad   Danio rerio Zebrafish  Drer\rhoac   Danio rerio Zebrafish  Drer\rhoab   Danio rerio Zebrafish  Drer\rhoaa   Danio rerio Zebrafish  Drer\rhoae   Xenopus tropicalis Western clawed frog  Xtro\rhob   Xenopus tropicalis Western clawed frog  Xtro\rhoa.2   Xenopus tropicalis Western clawed frog  Xtro\rhoc   Xenopus tropicalis Western clawed frog  Xtro\rhoa   Gallus gallus Domestic chicken  Ggal\RHOC   Gallus gallus Domestic chicken  Ggal\RHOA   Gallus gallus Domestic chicken  Ggal\cRhoB   Mus musculus House mouse  Mmus\Rhoa   Mus musculus House mouse  Mmus\Rhoc   Mus musculus House mouse  Mmus\4930544G11Rik   Mus musculus House mouse  Mmus\Rhob   Rattus norvegicus Norway rat  Rnor\RSA-14-44   Rattus norvegicus Norway rat  Rnor\Rhob   Rattus norvegicus Norway rat  Rnor\Rhoc   Homo sapiens Human  Hsap\RHOB   Homo sapiens Human  Hsap\RHOA   Homo sapiens Human  Hsap\RHOC
Human Orthologs (3)
Gene OMIM HGNC Hsap\RHOB     Hsap\RHOA     Hsap\RHOC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD11158 Drosophila sechellia Dsec\GM21657 Drosophila erecta Dere\GG20566 Drosophila yakuba Dyak\GE11751 Drosophila ananassae Dana\GF11290 Drosophila pseudoobscura pseudoobscura Dpse\GA25121 Drosophila persimilis Dper\GL20555 Drosophila willistoni Dwil\GK23137 Drosophila virilis Dvir\GJ22286 Drosophila mojavensis Dmoj\GI19151 Drosophila grimshawi Dgri\GH22067
Stocks & Reagents
Stocks Listed in FlyBase ( 38 )
Bloomington	28872 w*; P{UAS-Rho1.W}3 9527 P{GFP-Rho1}11, w1118 9528 w1118; P{GFP-Rho1}21 24762 w1118; P{GFP-Rho1}30 9392 P{UASp-GFP.Rho1}1, w* 7327 P{UAS-Rho1.N19}1.3, w* 7328 w*; P{UAS-Rho1.N19}2.1 7334 w*; P{UAS-Rho1.Sph}2.1 8144 w*; P{UAS-Rho1.V14}2.1
Harvard	- P{XP}Rho1d02325 - PBac{PB}Rho1c00122 - PBac{PB}Rho1c00252
	More stocks available...
Genomic Clones ( 2 )
	BACR04O19 BACR29I14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 148 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH20776 LD03419
Other clones	DPiM_GH20776 IP16828 IP16928
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04036 GH13626 GH15180 GH26530 GM01272 GM03149 GM06023 GM06308 GM09580 LD01073 LD09296 LD22066 LD29382 LD29467 LP06151 LP07589 LP23255 RE02650 RE04349 RE04920 RE05490 RE05866 RE06047 RE10465 RE17915 RE20016 RE21373 RE25311 RE30363 RE34911 RE35073 RE35782 RE38720 RE42962 RE45837 RE45866 RE46532 RE47135 RE47438 RE51960 RE52744 RE53193 RE53286 RE54651 RE54996 RE56517 RE62606 RE64089 RE64158 RE65427 RE70569 RE74006 RH04195 RH11842 RH14469 RH14641 RH16596 RH17262 RH28476 RH31720 RH33295 RH37261 RH44314 RH45963 RH46144 RH50439 RH52515 RH55740 RH56436 RH57956 RH58332 RH59427 RH60284 RH70132 RH70778 RH71310 RH71885 RH72687 RH73616 RH73664 SD13734 SD21262
Other clones	10936 32959 38121 40355 40420 50682 51125 53994 58435 61141 65284 65708 81667 103485 106174 106866 156403 159893 162433 175707 569925 CK01.31A.G6 CK01.50A.D8 Dmel_neb_014064_0698_1910 Dmel_neb_014781_0671_1415 Dmel_neb_015084_0637_2589 Dmel_neb_016117_0956_0694 EC14287 EC14729 EC25604 EC26006 EK026959 EK040221 EK063034 EK117106 EK142813 EK150935 EK154159 EK158861 EK162134 EK176759 EK178062 EK184737 EK193110 EK215221 EK243043 EK244238 EK259127 EK276334 EN15913 ESG019c.E21_A04 ESG0113c.B21.1_B03 FGM001E10 FGM004F11 FGM213C02 FGM302D02 FGM312C07 FGM324G03 RE01068 RE01816 RH01339
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0014020 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36775
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Rho1 l(2)52Fa (Halsell et al., 2000) Source for merge of: Rho1 l(2)k02107b (Magie et al., 1999)
Additional comments
Other Comments
	sti is necessary for correct Rho1 localisation at the cleavage site in late telophase. (Bassi et al., 2011) Rho1 is an upstream regulator of DAAM. (Matusek et al., 2006) The active Rho1 product promotes microtubule/microfilament crosslinking by sequestering the spir-PD isoform, preventing this protein from binding to spir-PC and capu. (Rosales-Nieves et al., 2006) Rho1 regulates shg but not arm localisation and the effect of loss of Rho1 is not enhanced or suppressed by removing p120ctn. (Fox et al., 2005) trc (He et al., 2005) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes no cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells. (Echard et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells. (Eggert et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells with increased or polarized (uneven) accumulation of F-actin. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Rho1 and Rac1 mediate the dynamic rearrangement of actin in peripheral glia. (Sepp and Auld, 2003) Rho1 appears to be required for the regulation of actin polymerisation and/or myosin activity that is critical for thr response of growth cones to midline repulsive signals. (Fritz and VanBerkum, 2002) Rho1 is necessary for normal morphology and behaviour of the leading edge cells during embryonic dorsal closure. (Jacinto et al., 2002) Rho1 is necessary for actin cable formation, but not cellular extenion formation during wound healing in the embryo. (Wood et al., 2002) Rho1 is required for neuroblast proliferation but not for neuronal survival in the mushroom body. (Lee et al., 2000) Together with Pkn, Rho1 mediates a pathway for cell shape changes in dorsal closure that is independent of the Rac GTPase-mediated Jun amino (N)-terminal kinase (JNK) cascade. (Lu and Settleman, 1999) Rho1 is required for many early events, both maternally and zygotically. Rho1 does not interact with members of the JNK signalling pathway. (Magie et al., 1999) pbl is linked through Rho1 activity to the reorganisation of the actin cytoskeleton. (Prokopenko et al., 1999) Rho1 is required for invagination of mesodermal and endodermal primordia during gastrulation and its activation is likely to be regulated by RhoGEF2. (Hacker and Perrimon, 1998) Complements S.cerevisiae RHO1 mutation. (Sasamura et al., 1997) Rho1 has been cloned and sequenced. Rho1 is required for the generation of tissue polarity. Genetic interactions indicate that Rho1 has a role in signalling mediated by fz and dsh. (Strutt et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057750 NM_134308 NM_134309 NM_166139 NM_206127 NM_206128 RefSeq (Proteins) • NP_477098 NP_599135 NP_599136 NP_725524 NP_995849 NP_995850 DDBJ / EMBL / GenBank • AA202784 AAA67042 AAF01183 AAF01184 AAF01185 AAF01186 AAF58066 AAM50190 AAM70944 AAM70945 AAM70946 AAQ22554 AAS64842 AAS64843 AAS64844 AC004248 AF177871 AF177872 AF177873 AF177874 AI389565 AW940792 AW941520 AY119536 BT010085 CAI61748 CS026563 CZ466213 CZ466317 CZ466328 CZ466342 CZ466702 CZ472750 CZ475601 CZ475602 CZ475782 L38311 Entrez Gene - A searchable database of RefSeq genes. • 36775 UniProtKB/Swiss-Prot • P48148 UniProtKB/TrEMBL • A4UZI6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Small GTPase superfamily (IPR001806) Small GTPase superfamily, Rho type (IPR003578) Small GTP-binding protein domain (IPR005225) P-loop containing nucleoside triphosphate hydrolase (IPR027417) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH20776
Linkouts
	BioGRID - A database of protein and genetic interactions • 62500 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0014020 DroID - A comprehensive database of gene and protein interactions. • FBgn0014020 DRSC - Results from RNAi screens. • FBgn0014020 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014020 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8416-RB;CG8416-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0014020 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 99990 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36775 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /cytoskel/rho1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36775 modMine - Data generated by the modENCODE project. • FBgn0014020
Synonyms & Secondary IDs ( 35 )
Reported As
Symbol Synonym	8416 (Ravi et al., 2009) 19549712 (Rojas et al., 2012) AAF01186 (Jekely, 2003) CG8416 (Rogers et al., 2003, Quinones-Coello, 2007, Jaspers et al., 2012, Perkins et al., 2009, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Cammarato et al., 2011, Howell et al., 2012, Colicelli, 2004) Dm Rho1 (Jekely, 2003) DmRHO-A (Mentzel and Raabe, 2005) dnRho (Fritz and VanBerkum, 2002) DRho (Noselli, 2002) DRho1 (Lawrence and Morel, 2003, Chen et al., 2002, Mizuno et al., 2002, Stronach and Perrimon, 1999, Blanke and Jackle, 2006) Drho1 (Raymond et al., 2001, Mizuno et al., 1999) dRho1 (Magie and Parkhurst, 2001) D-Rho1 (Ryabinina et al., 2006) dRhoA (Das et al., 2002) DrhoA (Greco et al., 2001, Noselli and Agnes, 1999, Agnes and Noselli, 1999, Noselli, 1998, Sasamura et al., 1997, Sasamura et al., 1995) DRhoA (Bateman and Van Vactor, 2001, Hacker et al., 1998, Hacker and Perrimon, 1998) E3.10/J3.8 (Halsell and Kiehart, 1998) l(2)52Fa   l(2)k02107b (BDGP Project Members, 1994-1999, ) n(2)k07236 (Spradling, 1999.12.9) P48148 (Rojas et al., 2012) Rho (McClatchey and Giovannini, 2005, Grzeschik and Knust, 2005, D'Avino et al., 2004, Fan et al., 2003, Bejsovec, 2005, Manning et al., 2002, Talbot and VanBerkum, 2005, Stewart and Ward, 2005, Rosales-Nieves et al., 2005, Jefferson et al., 2004, Stramer et al., 2004, Keung et al., 2004, Fox et al., 2004, Finn and Fehon, 2004, Avet-Rochex et al., 2004, Jekely, 2003, Bashaw et al., 2001, Shilo, 2003, Baum, 2002, Jacinto et al., 2001, Bokel and Brown, 2002, Etienne-Manneville and Hall, 2002, Speck et al., 2003, Matani et al., 2003, Park et al., 2002, Strutt et al., 2002, Fritz and Vanberkum, 2001, Fritz and VanBerkum, 2001, Bashaw et al., 2001, Jacinto and Martin, 2001, Johnson et al., 2001, Guichard et al., 2001, Chen et al., 2001, Bee et al., 2001, Chang and Ready, 2000, Luo, 2000, Seidensticker and Behrens, 2000, Bloor and Kiehart, 2000, Chen et al., 2000, Martin-Bermudo et al., 1999, Frasch, 1999, Montell, 1999, Crawford et al., 1998, Sutherland and Witke, 1999, Magie et al., 1999, Kerber et al., 1998, Bloor and Kiehart, 1998, O'Leary et al., 1998, Meyer and Parkhurst, 1997, Meyer and Parkhurst, 1997, Xu et al., 2006, Stewart et al., 2006, Kolesnikov, 2006, Homem et al., 2006, Xu et al., 2007, Artabazon et al., 2007, Talbot and VanBerkum, 2006, Fehon, 2006, Emery et al., 2005, Stramer et al., 2005, Gregory et al., 2007, Hozumi et al., 2006, Warren-Paquin et al., 2008, Muyskens and Guillemin, 2011, Kirilly et al., 2011, Avet-Rochex et al., 2007, Ng, 2008, Yang and Bashaw, 2006, Schotman et al., 2009, Gupta et al., 2009, Larson et al., 2008, Szafer-Glusman et al., 2011, Homem and Peifer, 2009, Uehara et al., 2010, Goldbach et al., 2010, Blanchard et al., 2010, He et al., 2010, Ball et al., 2010, Dorsten et al., 2007) RHO (Muller and Littlewood-Evans, 2001) rho (Pandur et al., 2002, Pazman and Haynes, 2000, Beitel and Krasnow, 1998, Huelsmann et al., 2006, O'Keefe et al., 2007, Brown et al., 2007, Jean et al., 2012) Rho1 (Sweeney et al., 2008, Aleksic et al., 2009, Wenzl and Grosshans, 2007, Neisch et al., 2007, Mulinari et al., 2007, Zhang et al., 2007, Fox et al., 2005, Luo, 2007.3.23, Padash Barmchi et al., 2005, Stramer et al., 2005, Brodu and Casanova, 2006, Rogers et al., 2003, Sommer et al., 2005, Taniguchi et al., 2011, Vidal et al., 2006, Simoes et al., 2006, Avet-Rochex et al., 2005, Dean and Spudich, 2006, Kadandale et al., 2010, He et al., 2005, Lovegrove et al., 2006, Quinones-Coello, 2007, Bakal et al., 2007, Fox and Peifer, 2007, Polaski et al., 2006, Patch et al., 2008, Artabazon et al., 2008, Benjamin et al., 2008, Xu et al., 2008, Morgan and Kalm, 2008, Koelsch and Leptin, 2008, Bakal et al., 2007, Vig et al., 2006, Larson et al., 2008, Chen et al., 2005, Minidorff et al., 2007, Baek et al., 2010, Zhou et al., 2008, Betson and Settleman, 2007, Minidorff et al., 2007, Szafer-Glusman et al., 2011, Axelsson et al., 2011, Brumby et al., 2011, Degennaro et al., 2011, Xu et al., 2011, Johnson et al., 2011, Morris et al., 2012, Hickson and O'Farrell, 2008, Johnson et al., 2008, Taniguchi et al., 2007, Homem and Peifer, 2008, Paladi and Tepass, 2004, Williams et al., 2007, Matusek et al., 2008, Xu et al., 2008, Alves-Silva et al., 2008, Frank et al., 2009, Webb et al., 2009, Widmann and Dahmann, 2009, Snee and Macdonald, 2009, Dworkin et al., 2009, Liu et al., 2009, Asensio et al., 2010, Massarwa et al., 2009, Yan et al., 2009, Zeitlinger et al., 2007, Cordero et al., 2007, Warner and Longmore, 2009, Rothenfluh et al., 2006, Mirouse et al., 2009, Warner and Longmore, 2009, Patch et al., 2009, Sato et al., 2010, Zimmerman et al., 2010, Campos et al., 2010, Sekyrova et al., 2010, Pataki et al., 2010, Neisch et al., 2010, von Hilchen et al., 2010, Renault et al., 2010, Warner, 2010.9.15, Blanchard et al., 2010, Wang and Riechmann, 2007, Yu et al., 2010, Beltran et al., 2007, Song and Giniger, 2011, Simões et al., 2010, Tanaka et al., 2011, van Impel et al., 2009, Hughes et al., 2010, Ball et al., 2010, Qin et al., 2008, Howell et al., 2012, Sun et al., 2011, Elsaesser et al., 2010, Jeong et al., 2012, Baek et al., 2012, Felix et al., 2012) rho1 (Echard et al., 2004, Cafferty et al., 2005, Somma et al., 2002, Settleman, 2001, Jacinto et al., 2002, Schock and Perrimon, 2002, Somma et al., 2001, Nolan et al., 1998, Artabazon et al., 2007, Dworkin and Gibson, 2006, Dean et al., 2005, Vlachos and Harden, 2011, Carrillo et al., 2010, Wang and Riechmann, 2007, Sarkar et al., 2007, van Impel et al., 2009, Verdier et al., 2006, Higuchi et al., 2009, Bertet et al., 2009, Shao et al., 2010, Neubueser and Hipfner, 2010, Pilgram et al., 2011) RHO1 (Mirey et al., 2003) RhoA (Kerkhoff, 2006, Hu et al., 2005, Zhu et al., 2005, Govek, 2005, Wilson et al., 2005, Shandala et al., 2004, Harden et al., 2002, Balasubramanian et al., 2004, Wilk et al., 2004, Ishimaru et al., 2004, Polesello and Payre, 2004, Strutt and Strutt, 2003, Goda and Davis, 2003, Starz-Gaiano and Montell, 2004, Bayer et al., 2003, Ghabrial et al., 2003, Halsell et al., 2004, Jacinto and Baum, 2003, Solnica-Krezel and Eaton, 2003, Strutt, 2003, Strutt and Strutt, 2003, Pasterkamp and Kolodkin, 2003, Adler and Lee, 2001, Patel and Van Vactor, 2002, Wood et al., 2002, Acebes and Ferrus, 2000, Gao and Bogert, 2003, Echard and O'Farrell, 2003, Adler, 2002, Tree et al., 2002, Mlodzik, 2002, Aigaki et al., 2002, Tan et al., 2003, Castellani and Rougon, 2002, Wedlich, 2002, Lee et al., 2003, Schumacher et al., 2003, von Kalm et al., 2002, Bloor and Kiehart, 2002, Strutt et al., 2002, Kolodziej and Lee, 2002, Bloor and Kiehart, 2001, Wiemann et al., 2001, O'Keefe et al., 2000, Lee and Kolodziej, 2002, Billuart et al., 2001, Whitford and Ghosh, 2001, Bloor and Kiehart, 2001, Johnstone and Lasko, 2001, Hu et al., 2001, Billuart et al., 2001, Cooper and Strutt, 2001, Das and Mlodzik, 2001, Strutt, 2001, Winter et al., 2001, Winter et al., 2001, Pilch et al., 2001, Somers et al., 2001, Uchida et al., 2001, Sotillos and Campuzano, 2000, Fanto, 2000, Fanto et al., 2000, Newsome et al., 2000, Halsell et al., 2000, Pazman et al., 2000, Mlodzik, 2000, Lee et al., 2000, Halsell and Kiehart, 2000, Peifer and Tepass, 2000, Mlodzik, 1999, Kollmar, 1999, Rangarajan et al., 1999, Paricio et al., 1999, Sawamoto et al., 1999, Thomas and Wassarman, 1999, Reifegerste and Moses, 1999, Sawamoto et al., 1999, Sutherland and Witke, 1999, Lee et al., 1999, Harden et al., 1999, Harden et al., 1999, Halsell and Kiehart, 1999, Asha et al., 1999, Goberdhan and Wilson, 1998, Shulman et al., 1998, Boutros et al., 1998, Tree and Gubb, 1998, Axelrod et al., 1998, Dale, 1998, Strutt et al., 1997, Martin-Blanco, 1997, Eaton, 1997, Van Aelst and D'Souza-Schorey, 1997, Strutt et al., 1997, Ng and Luo, 2005, Matusek et al., 2005, Ruggiero et al., 2006, Fox and Kalm, 2006, Tyler et al., 2007, Impel et al., 2007, Matusek et al., 2006, McBride et al., 2006, Gregory et al., 2007, Mirkovic and Mlodzik, 2006, Roubinet et al., 2007, Nahm et al., 2006, Tolwinski, 2007, Sanny et al., 2006, Chung et al., 2007, Srahna et al., 2006, Mirkovic et al., 2011, Morgan and Kalm, 2008, Gregory et al., 2008, D'Avino et al., 2005, Taniguchi et al., 2007, Muñoz-Descalzo et al., 2007, Montrasio et al., 2007, Szafer-Glusman et al., 2011, Nahm and Lee, 2011, Corrigall et al., 2007, Bastock and Strutt, 2007, Piekny et al., 2005, Carreno et al., 2008, Albertson et al., 2008, Cao et al., 2008, Llense and Martín-Blanco, 2008, Minin et al., 2006, Bidla et al., 2007, Rodriguez-Diaz et al., 2008, Schotman et al., 2009, Franke et al., 2007, Bassi et al., 2011, Cao et al., 2010, Pataki et al., 2010, Matusek et al., 2008, Blanchard et al., 2010, Colinet et al., 2010, Zeng et al., 2010, Ben El Kadhi et al., 2011, Matsubara et al., 2011, Colinet et al., 2007, Nahm et al., 2010, Cook et al., 2012) rhoA (Brumby et al., 2004, Kockel et al., 2001, Grueber and Jan, 2004, Pandur et al., 2002, Jacinto et al., 2002, Zhu et al., 2002, Kadam and Reuter, 2001, Hemavathy et al., 2000, Schock and Perrimon, 2000, Stronach and Perrimon, 1999, Boutros and Mlodzik, 1999, Cox and Peifer, 1998, Cadigan and Nusse, 1997, Molnar and de Celis, 2006, Jenny et al., 2005, Yang and Bashaw, 2006, Asensio et al., 2010, Chung et al., 2009, Djiane and Mlodzik, 2010, Reid et al., 2012) Rho A (Dawes-Hoang and Wieschaus, 2001) Rho GTPase (Miller, 2003, Vincent and Magee, 2002) Rho kinase (Kiehart, 2003, Barros et al., 2003) RhoN19 (Blanchard et al., 2010)
Name Synonym	Rho1 (Prokopenko and Chia, 2008, Zhou et al., 2008, Zimmerman et al., 2010, Cammarato et al., 2011) rho1 (Verdier et al., 2006) rho1 kinase (Dworkin and Gibson., 2006) RhoA (Fanto and McNeill, 2004) RhoA kinase (Morris et al., 2012) Rho GTPase (Sepp and Auld, 2003, Xu et al., 2007) Rho kinase (Nikolaidou and Barrett, 2005, Mok et al., 2005) rho kinase (Dworkin and Gibson, 2006)
Secondary FlyBase IDs
	FBgn0014021 FBgn0024874 FBgn0024880
References ( 528 )
Generate a list of	All references relating to this gene ( 528 )
List References by type	Research paper  ( 268 ) Supplementary material  ( 18 ) Review  ( 99 ) Personal communication to FlyBase  ( 18 ) Abstract  ( 114 ) FlyBase analysis  ( 3 ) Conference report  ( 2 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Thesis  ( 1 )
Recent research papers ( 35 )
	Warrington et al., 2013, Development 140(5): 1045--1054 The Frizzled-dependent planar polarity pathway locally promotes E-cadherin turnover via recruitment of RhoGEF2. [FBrf0220829] Baek et al., 2012, FEBS Lett. 586(6): 772--777 Requirement for Pak3 in Rac1-induced organization of actin and myosin during Drosophila larval wound healing. [FBrf0217868] Bischoff, 2012, Dev. Biol. 363(1): 179--190 Lamellipodia-based migrations of larval epithelial cells are required for normal closure of the adult epidermis of Drosophila. [FBrf0217475] Cook et al., 2012, PLoS ONE 7(9): e44440 Increased RhoA Prenylation in the loechrig (loe) Mutant Leads to Progressive Neurodegeneration. [FBrf0219441] Felix et al., 2012, Genetics 191(3): 989--1002 Age-Specific Variation in Immune Response in Drosophila melanogaster Has a Genetic Basis. [FBrf0218944] Howell et al., 2012, Immunogenetics 64(2): 155--161 A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response. [FBrf0217123] Jaspers et al., 2012, J. Biol. Chem. 287(44): 36756--36765 The claudin megatrachea protein complex. [FBrf0219819] Jean et al., 2012, Mol. Biol. Cell 23(14): 2723--2740 Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling. [FBrf0218866] Jeong et al., 2012, Neuron 76(4): 721--734 The Control of Semaphorin-1a-Mediated Reverse Signaling by Opposing Pebble and RhoGAPp190 Functions in Drosophila. [FBrf0219982] Menant and Karess, 2012, Cell Cycle 11(15): 2856--2863 Inducing "cytokinesis" without mitosis in unfertilized Drosophila eggs. [FBrf0219101] Morris et al., 2012, Genetics 191(4): 1227--1238 Divergent Functions Through Alternative Splicing: The Drosophila CRMP Gene in Pyrimidine Metabolism, Brain, and Behavior. [FBrf0219149] Reid et al., 2012, Front. Cell. Infect. Microbiol. 2: 24 Identification of genetic modifiers of CagA-induced epithelial disruption in Drosophila. [FBrf0219288] Wandler and Guillemin, 2012, PLoS Pathog. 8(10): e1002939 Transgenic Expression of the Helicobacter pylori Virulence Factor CagA Promotes Apoptosis or Tumorigenesis through JNK Activation in Drosophila. [FBrf0219744] Axelsson et al., 2011, BMC Bioinformatics 12: 342 Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi. [FBrf0215222] Bassi et al., 2011, J. Cell Biol. 195(4): 595--603 Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis. [FBrf0216679] Ben El Kadhi et al., 2011, Curr. Biol. 21(12): 1074--1079 The Inositol 5-Phosphatase dOCRL Controls PI(4,5)P2 Homeostasis and Is Necessary for Cytokinesis. [FBrf0213972] Brumby et al., 2011, Genetics 188(1): 105--125 Identification of Novel Ras-Cooperating Oncogenes in Drosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis. [FBrf0213630] Degennaro et al., 2011, Dev. 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