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Gene Dmel\Su(Tpl)

General Information
Symbol	Dmel\Su(Tpl)	Species	D. melanogaster
Name	Su(Tpl)	Annotation symbol	CG32217
Feature type	protein_coding_gene	FlyBase ID	FBgn0014037
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	dELL, ELL, l(3)76BDs, SR3-4A, SY3-1
Genomic Location
Chromosome (arm)	3L	Recombination map	3-46.5
Cytogenetic map	76D3-76D4	Sequence location	3L:19,884,505..19,902,500 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Su(Tpl) is referred to in FlyBase by the symbol Dmel\Su(Tpl) (CG32217, FBgn0014037). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: regulation of DNA-dependent transcription in response to stress; wing disc dorsal/ventral pattern formation. 38 alleles are reported. The phenotypes of these alleles are annotated with: embryonic abdominal segment 3; embryonic abdominal segment 8; embryonic head; embryonic abdominal segment 1; embryonic abdominal segment 5; embryonic abdominal segment 4; embryonic abdominal segment 2; embryonic mesothoracic segment; embryonic abdominal segment 6; embryonic metathoracic segment. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Occludin/RNA polymerase II elongation factor, ELL domain; RNA polymerase II elongation factor ELL. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, adult midgut, adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, adult fat body, virgin spermatheca, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1639318_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Su(Tpl). Gene sequence location is 3L:19884505..19902500.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation.
FB2012_01	Sequence features BKN21726 HFA10954 References Lin et al., 2010, Mol. Cell 37(3): 429--437
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 76D3-76D4   Limits computationally determined from genome sequence between P{lacW}l(3)L3809L3809 and P{lacW}l(3)L1243L1243&P{lacW}Mi-2j3D4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 76D-76D   (determined by in situ hybridisation)   (Szeged Stock Center, 1998-) 76D-76D   (determined by in situ hybridisation)   (Deak et al., 1997) 76C-76D   On basis of meiotic mapping (details unspecified).   (Karim et al., 1996)
Experimentally Determined Recombination Data
Location	3-46.5 (Dorer et al., 1995) 3- (Karim et al., 1996, Neufeld et al., 1998)
Left of (cM)	kni (Dorer et al., 1995)
Right of (cM)	st (Dorer et al., 1995)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Su(Tpl) for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Su(Tpl)-RA FBtr0074920  NM_140898   4282   1059 Su(Tpl)-RB FBtr0302047  NM_001170006   4277   1059
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Su(Tpl)-PA   FBpp0074689   114.9   1059   9.71     NP_649155   AAF49098 Su(Tpl)-PB   FBpp0291257   114.9   1059   9.71     NP_001163477   ACZ94748
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Occludin/RNA polymerase II elongation factor, ELL domain (IPR010844) RNA polymerase II elongation factor ELL (IPR019464)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202797   AA246462   AA392430   AA441314   AA539366   AA695449   AA950503   AE014296 AAF49098   AE014296 ACZ94748   AF416770 AAL13036   AQ026314   AW942250   AY061161 AAL28709   BF487419   BF490681   BF498702   BF506646   BG638592   BI354012   BP546159   BP551670   BQ102788   BQ102821   BT023955   BT050407   BT058015   CL528124   CO188653   CO263778   CO274968   CO277212   CO277822   CO279559   CO280515   CO284688   CO296697   CO301075   CO304147   CO311115   CO325256   CO325429   CO327882   CO342379   CO343057   DQ138848 ABA86454   EC060788   EC063219   EC069280   EC071732   EC072212   EC083176   EC087220   EC202170   EC208863   EC215890   EC222226   EC223863   EC225520   EC232253   EC232418   EC245856   EC252372   EC252856   GO271012
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q2XY14 Q95RS9 Q95SC1 Q95VE6 Q9VW51
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0014037    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0014037 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0014037 expression level Developmental Stage   Expression Level embryo 00-02hr    9601 embryo 02-04hr    9842 embryo 04-06hr    5925 embryo 06-08hr    6016 embryo 08-10hr    5672 embryo 10-12hr    4563 embryo 12-14hr    4165 embryo 14-16hr    6936 embryo 16-18hr    6398 embryo 18-20hr    5809 embryo 20-22hr    4484 embryo 22-24hr    4090 larva L1    2637 larva L2    2382 larva L3 12hr old    2656 larva L3 puffstage 1-2    1446 larva L3 puffstage 3-6    2917 larva L3 puffstage 7-9    3265 white prepupae new    3011 white prepupae 12hr    3269 white prepupae 24hr    3415 pupae 2d postWPP    3475 pupae 3d postWPP    2489 pupae 4d postWPP    3668 adult male 01day    3255 adult male 05day    3981 adult male 30day    3927 adult female 01day    4502 adult female 05day    5625 adult female 30day    6380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9601) embryo 02-04hr  (9842) embryo 04-06hr  (5925) embryo 06-08hr  (6016) embryo 08-10hr  (5672) embryo 10-12hr  (4563) embryo 12-14hr  (4165) embryo 14-16hr  (6936) embryo 16-18hr  (6398) embryo 18-20hr  (5809) embryo 20-22hr  (4484) embryo 22-24hr  (4090) larva L1  (2637) larva L2  (2382) larva L3 12hr old  (2656) larva L3 puffstage 1-2  (1446) larva L3 puffstage 3-6  (2917) larva L3 puffstage 7-9  (3265) white prepupae new  (3011) white prepupae 12hr  (3269) white prepupae 24hr  (3415) pupae 2d postWPP  (3475) pupae 3d postWPP  (2489) pupae 4d postWPP  (3668) adult male 01day  (3255) adult male 05day  (3981) adult male 30day  (3927) adult female 01day  (4502) adult female 05day  (5625) adult female 30day  (6380) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9601) embryo 02-04hr  (9842) embryo 04-06hr  (5925) embryo 06-08hr  (6016) embryo 08-10hr  (5672) embryo 10-12hr  (4563) embryo 12-14hr  (4165) embryo 14-16hr  (6936) embryo 16-18hr  (6398) embryo 18-20hr  (5809) embryo 20-22hr  (4484) embryo 22-24hr  (4090) larva L1  (2637) larva L2  (2382) larva L3 12hr old  (2656) larva L3 puffstage 1-2  1446 larva L3 puffstage 3-6  (2917) larva L3 puffstage 7-9  (3265) white prepupae new  (3011) white prepupae 12hr  (3269) white prepupae 24hr  (3415) pupae 2d postWPP  (3475) pupae 3d postWPP  (2489) pupae 4d postWPP  (3668) adult male 01day  (3255) adult male 05day  (3981) adult male 30day  (3927) adult female 01day  (4502) adult female 05day  (5625) adult female 30day  (6380) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9601 embryo 02-04hr    9842 embryo 04-06hr    5925 embryo 06-08hr    6016 embryo 08-10hr    5672 embryo 10-12hr    4563 embryo 12-14hr    4165 embryo 14-16hr    6936 embryo 16-18hr    6398 embryo 18-20hr    5809 embryo 20-22hr    4484 embryo 22-24hr    4090 larva L1    2637 larva L2    2382 larva L3 12hr old    2656 larva L3 puffstage 1-2    1446 larva L3 puffstage 3-6    2917 larva L3 puffstage 7-9    3265 white prepupae new    3011 white prepupae 12hr    3269 white prepupae 24hr    3415 pupae 2d postWPP    3475 pupae 3d postWPP    2489 pupae 4d postWPP    3668 adult male 01day    3255 adult male 05day    3981 adult male 30day    3927 adult female 01day    4502 adult female 05day    5625 adult female 30day    6380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9601 embryo 02-04hr    9842 embryo 04-06hr    5925 embryo 06-08hr    6016 embryo 08-10hr    5672 embryo 10-12hr    4563 embryo 12-14hr    4165 embryo 14-16hr    6936 embryo 16-18hr    6398 embryo 18-20hr    5809 embryo 20-22hr    4484 embryo 22-24hr    4090 larva L1    2637 larva L2    2382 larva L3 12hr old    2656 larva L3 puffstage 1-2    1446 larva L3 puffstage 3-6    2917 larva L3 puffstage 7-9    3265 white prepupae new    3011 white prepupae 12hr    3269 white prepupae 24hr    3415 pupae 2d postWPP    3475 pupae 3d postWPP    2489 pupae 4d postWPP    3668 adult male 01day    3255 adult male 05day    3981 adult male 30day    3927 adult female 01day    4502 adult female 05day    5625 adult female 30day    6380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0014037 expression level Developmental Stage   Expression Level embryo 00-02hr    9601 embryo 02-04hr    9842 embryo 04-06hr    5925 embryo 06-08hr    6016 embryo 08-10hr    5672 embryo 10-12hr    4563 embryo 12-14hr    4165 embryo 14-16hr    6936 embryo 16-18hr    6398 embryo 18-20hr    5809 embryo 20-22hr    4484 embryo 22-24hr    4090 larva L1    2637 larva L2    2382 larva L3 12hr old    2656 larva L3 puffstage 1-2    1446 larva L3 puffstage 3-6    2917 larva L3 puffstage 7-9    3265 white prepupae new    3011 white prepupae 12hr    3269 white prepupae 24hr    3415 pupae 2d postWPP    3475 pupae 3d postWPP    2489 pupae 4d postWPP    3668 adult male 01day    3255 adult male 05day    3981 adult male 30day    3927 adult female 01day    4502 adult female 05day    5625 adult female 30day    6380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9601) embryo 02-04hr  (9842) embryo 04-06hr  (5925) embryo 06-08hr  (6016) embryo 08-10hr  (5672) embryo 10-12hr  (4563) embryo 12-14hr  (4165) embryo 14-16hr  (6936) embryo 16-18hr  (6398) embryo 18-20hr  (5809) embryo 20-22hr  (4484) embryo 22-24hr  (4090) larva L1  (2637) larva L2  (2382) larva L3 12hr old  (2656) larva L3 puffstage 1-2  (1446) larva L3 puffstage 3-6  (2917) larva L3 puffstage 7-9  (3265) white prepupae new  (3011) white prepupae 12hr  (3269) white prepupae 24hr  (3415) pupae 2d postWPP  (3475) pupae 3d postWPP  (2489) pupae 4d postWPP  (3668) adult male 01day  (3255) adult male 05day  (3981) adult male 30day  (3927) adult female 01day  (4502) adult female 05day  (5625) adult female 30day  (6380) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9601) embryo 02-04hr  (9842) embryo 04-06hr  (5925) embryo 06-08hr  (6016) embryo 08-10hr  (5672) embryo 10-12hr  (4563) embryo 12-14hr  (4165) embryo 14-16hr  (6936) embryo 16-18hr  (6398) embryo 18-20hr  (5809) embryo 20-22hr  (4484) embryo 22-24hr  (4090) larva L1  (2637) larva L2  2382 larva L3 12hr old  (2656) larva L3 puffstage 1-2  1446 larva L3 puffstage 3-6  (2917) larva L3 puffstage 7-9  (3265) white prepupae new  (3011) white prepupae 12hr  (3269) white prepupae 24hr  (3415) pupae 2d postWPP  (3475) pupae 3d postWPP  (2489) pupae 4d postWPP  (3668) adult male 01day  (3255) adult male 05day  (3981) adult male 30day  (3927) adult female 01day  (4502) adult female 05day  (5625) adult female 30day  (6380) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9601 embryo 02-04hr    9842 embryo 04-06hr    5925 embryo 06-08hr    6016 embryo 08-10hr    5672 embryo 10-12hr    4563 embryo 12-14hr    4165 embryo 14-16hr    6936 embryo 16-18hr    6398 embryo 18-20hr    5809 embryo 20-22hr    4484 embryo 22-24hr    4090 larva L1    2637 larva L2    2382 larva L3 12hr old    2656 larva L3 puffstage 1-2    1446 larva L3 puffstage 3-6    2917 larva L3 puffstage 7-9    3265 white prepupae new    3011 white prepupae 12hr    3269 white prepupae 24hr    3415 pupae 2d postWPP    3475 pupae 3d postWPP    2489 pupae 4d postWPP    3668 adult male 01day    3255 adult male 05day    3981 adult male 30day    3927 adult female 01day    4502 adult female 05day    5625 adult female 30day    6380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9601 embryo 02-04hr    9842 embryo 04-06hr    5925 embryo 06-08hr    6016 embryo 08-10hr    5672 embryo 10-12hr    4563 embryo 12-14hr    4165 embryo 14-16hr    6936 embryo 16-18hr    6398 embryo 18-20hr    5809 embryo 20-22hr    4484 embryo 22-24hr    4090 larva L1    2637 larva L2    2382 larva L3 12hr old    2656 larva L3 puffstage 1-2    1446 larva L3 puffstage 3-6    2917 larva L3 puffstage 7-9    3265 white prepupae new    3011 white prepupae 12hr    3269 white prepupae 24hr    3415 pupae 2d postWPP    3475 pupae 3d postWPP    2489 pupae 4d postWPP    3668 adult male 01day    3255 adult male 05day    3981 adult male 30day    3927 adult female 01day    4502 adult female 05day    5625 adult female 30day    6380 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0014037    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0014037 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult central nervous system, adult midgut, adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult testis, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, adult fat body, virgin spermatheca, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0014037 expression level Tissue   Expression Level Larval Central Nervous System    422.15 Larval Midgut    404.1 Larval Hindgut    413.8 Larval Malpighian Tubules    485.4 Larval Fat Body    549.7 Larval Salivary Gland    839.8 Larval Trachea    595.05 Larval Carcass    591.375 Adult Head    388.1 Adult Eye    388.075 Adult Brain    566.8 Adult Thoracic-Abdominal Ganglion    581.2 Adult Crop    497.4 Adult Midgut    528.9 Adult Hindgut    498.3 Adult Malpighian Tubules    587.3 Adult Fat Body    488.1 Adult Salivary Gland    884.8 Adult Heart    409.975 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca    505.2 Adult Ovary    542.8 Adult Testis    709.7 Adult Male Accessory Gland    376.5 Adult Carcass    550.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    422.15 Larval Midgut    404.1 Larval Hindgut    413.8 Larval Malpighian Tubules    485.4 Larval Fat Body  (549.7) Larval Salivary Gland  (839.8) Larval Trachea  (595.05) Larval Carcass  (591.375) Adult Head    388.1 Adult Eye    388.075 Adult Brain  (566.8) Adult Thoracic-Abdominal Ganglion  (581.2) Adult Crop    497.4 Adult Midgut  528.9 Adult Hindgut    498.3 Adult Malpighian Tubules  (587.3) Adult Fat Body    488.1 Adult Salivary Gland  (884.8) Adult Heart    409.975 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca  505.2 Adult Ovary  (542.8) Adult Testis  (709.7) Adult Male Accessory Gland    376.5 Adult Carcass  (550.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    422.15 Larval Midgut    404.1 Larval Hindgut    413.8 Larval Malpighian Tubules    485.4 Larval Fat Body    549.7 Larval Salivary Gland    839.8 Larval Trachea    595.05 Larval Carcass    591.375 Adult Head    388.1 Adult Eye    388.075 Adult Brain    566.8 Adult Thoracic-Abdominal Ganglion    581.2 Adult Crop    497.4 Adult Midgut    528.9 Adult Hindgut    498.3 Adult Malpighian Tubules    587.3 Adult Fat Body    488.1 Adult Salivary Gland    884.8 Adult Heart    409.975 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca    505.2 Adult Ovary    542.8 Adult Testis    709.7 Adult Male Accessory Gland    376.5 Adult Carcass    550.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    422.15 Larval Midgut    404.1 Larval Hindgut    413.8 Larval Malpighian Tubules    485.4 Larval Fat Body    549.7 Larval Salivary Gland    839.8 Larval Trachea    595.05 Larval Carcass    591.375 Adult Head    388.1 Adult Eye    388.075 Adult Brain    566.8 Adult Thoracic-Abdominal Ganglion    581.2 Adult Crop    497.4 Adult Midgut    528.9 Adult Hindgut    498.3 Adult Malpighian Tubules    587.3 Adult Fat Body    488.1 Adult Salivary Gland    884.8 Adult Heart    409.975 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca    505.2 Adult Ovary    542.8 Adult Testis    709.7 Adult Male Accessory Gland    376.5 Adult Carcass    550.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0014037 expression level Tissue   Expression Level Larval Central Nervous System    422.15 Larval Midgut    404.1 Larval Hindgut    413.8 Larval Malpighian Tubules    485.4 Larval Fat Body    549.7 Larval Salivary Gland    839.8 Larval Trachea    595.05 Larval Carcass    591.375 Adult Head    388.1 Adult Eye    388.075 Adult Brain    566.8 Adult Thoracic-Abdominal Ganglion    581.2 Adult Crop    497.4 Adult Midgut    528.9 Adult Hindgut    498.3 Adult Malpighian Tubules    587.3 Adult Fat Body    488.1 Adult Salivary Gland    884.8 Adult Heart    409.975 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca    505.2 Adult Ovary    542.8 Adult Testis    709.7 Adult Male Accessory Gland    376.5 Adult Carcass    550.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    422.15 Larval Midgut    404.1 Larval Hindgut    413.8 Larval Malpighian Tubules    485.4 Larval Fat Body  549.7 Larval Salivary Gland  (839.8) Larval Trachea  595.05 Larval Carcass  591.375 Adult Head    388.1 Adult Eye    388.075 Adult Brain  566.8 Adult Thoracic-Abdominal Ganglion  581.2 Adult Crop    497.4 Adult Midgut  528.9 Adult Hindgut    498.3 Adult Malpighian Tubules  587.3 Adult Fat Body    488.1 Adult Salivary Gland  (884.8) Adult Heart    409.975 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca  505.2 Adult Ovary  542.8 Adult Testis  709.7 Adult Male Accessory Gland    376.5 Adult Carcass  550.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    422.15 Larval Midgut    404.1 Larval Hindgut    413.8 Larval Malpighian Tubules    485.4 Larval Fat Body    549.7 Larval Salivary Gland    839.8 Larval Trachea    595.05 Larval Carcass    591.375 Adult Head    388.1 Adult Eye    388.075 Adult Brain    566.8 Adult Thoracic-Abdominal Ganglion    581.2 Adult Crop    497.4 Adult Midgut    528.9 Adult Hindgut    498.3 Adult Malpighian Tubules    587.3 Adult Fat Body    488.1 Adult Salivary Gland    884.8 Adult Heart    409.975 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca    505.2 Adult Ovary    542.8 Adult Testis    709.7 Adult Male Accessory Gland    376.5 Adult Carcass    550.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    422.15 Larval Midgut    404.1 Larval Hindgut    413.8 Larval Malpighian Tubules    485.4 Larval Fat Body    549.7 Larval Salivary Gland    839.8 Larval Trachea    595.05 Larval Carcass    591.375 Adult Head    388.1 Adult Eye    388.075 Adult Brain    566.8 Adult Thoracic-Abdominal Ganglion    581.2 Adult Crop    497.4 Adult Midgut    528.9 Adult Hindgut    498.3 Adult Malpighian Tubules    587.3 Adult Fat Body    488.1 Adult Salivary Gland    884.8 Adult Heart    409.975 Adult VirginFemale Spermatheca    490.6 Adult InseminatedFemale Spermatheca    505.2 Adult Ovary    542.8 Adult Testis    709.7 Adult Male Accessory Gland    376.5 Adult Carcass    550.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    388.1   NA  Eye    388.075   NA  Brain    566.8   422.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    581.2   NA  Crop    497.4   404.1  Midgut    528.9   413.8  Hindgut    498.3   485.4  Malpighian Tubules    587.3   549.7  Fat Body    488.1   839.8  Salivary Gland    884.8   NA  Heart    409.975   595.05  Trachea    NA   NA  VirginFemale Spermatheca    490.6   NA  InseminatedFemale Spermatheca    505.2   NA  Ovary    542.8   NA  Testis    709.7   NA  Male Accessory Gland    376.5   591.375  Carcass    550.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_01
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014037 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32217-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PU Su(Tpl)dsRNA.Sym.Scer\UAS lethal | embryonic stage (with Su(Tpl)10) Su(Tpl)S-192 lethal | embryonic stage (with Su(Tpl)17) Su(Tpl)s1 Su(Tpl)S-192 lethal | embryonic stage (with Su(Tpl)s1) Su(Tpl)17 Su(Tpl)S-192 Su(Tpl)XS-706 lethal | embryonic stage (with Su(Tpl)S-192) Su(Tpl)10 Su(Tpl)17 Su(Tpl)s1 Su(Tpl)XS-706 lethal | embryonic stage (with Su(Tpl)XS-706) Su(Tpl)s1 Su(Tpl)S-192 lethal | larval stage | recessive Su(Tpl)S000606 Su(Tpl)S085401 lethal | recessive Su(Tpl)10 Su(Tpl)17 Su(Tpl)38 Su(Tpl)DI998 Su(Tpl)EZ1217 Su(Tpl)J34 Su(Tpl)s1 Su(Tpl)s2 Su(Tpl)S-192 Su(Tpl)S000606 Su(Tpl)S085401 Su(Tpl)XS-706 semi-lethal, with Scer\GAL4pnr-MD237 Su(Tpl)GD10818 Phenotype manifest in Allele embryonic abdominal segment 1 (with Su(Tpl)10) Su(Tpl)S-192 embryonic abdominal segment 1 (with Su(Tpl)s1) Su(Tpl)S-192 Su(Tpl)XS-706 embryonic abdominal segment 1 (with Su(Tpl)S-192) Su(Tpl)10 Su(Tpl)XS-706 Su(Tpl)s1 embryonic abdominal segment 1 (with Su(Tpl)XS-706) Su(Tpl)S-192 Su(Tpl)s1 embryonic abdominal segment 2 (with Su(Tpl)10) Su(Tpl)S-192 embryonic abdominal segment 2 (with Su(Tpl)17) Su(Tpl)s1 embryonic abdominal segment 2 (with Su(Tpl)s1) Su(Tpl)17 Su(Tpl)S-192 Su(Tpl)XS-706 embryonic abdominal segment 2 (with Su(Tpl)S-192) Su(Tpl)10 Su(Tpl)XS-706 Su(Tpl)s1 embryonic abdominal segment 2 (with Su(Tpl)XS-706) Su(Tpl)S-192 Su(Tpl)s1 embryonic abdominal segment 3 (with Su(Tpl)10) Su(Tpl)S-192 embryonic abdominal segment 3 (with Su(Tpl)17) Su(Tpl)S-192 Su(Tpl)s1 embryonic abdominal segment 3 (with Su(Tpl)s1) Su(Tpl)17 embryonic abdominal segment 3 (with Su(Tpl)S-192) Su(Tpl)10 Su(Tpl)17 embryonic abdominal segment 4 (with Su(Tpl)10) Su(Tpl)S-192 embryonic abdominal segment 4 (with Su(Tpl)17) Su(Tpl)S-192 Su(Tpl)s1 embryonic abdominal segment 4 (with Su(Tpl)s1) Su(Tpl)17 embryonic abdominal segment 4 (with Su(Tpl)S-192) Su(Tpl)10 Su(Tpl)17 Su(Tpl)XS-706 embryonic abdominal segment 4 (with Su(Tpl)XS-706) Su(Tpl)S-192 embryonic abdominal segment 5 (with Su(Tpl)10) Su(Tpl)S-192 embryonic abdominal segment 5 (with Su(Tpl)17) Su(Tpl)S-192 Su(Tpl)s1 embryonic abdominal segment 5 (with Su(Tpl)s1) Su(Tpl)17 Su(Tpl)S-192 Su(Tpl)XS-706 embryonic abdominal segment 5 (with Su(Tpl)S-192) Su(Tpl)10 Su(Tpl)17 Su(Tpl)s1 embryonic abdominal segment 5 (with Su(Tpl)XS-706) Su(Tpl)s1 embryonic abdominal segment 6 (with Su(Tpl)10) Su(Tpl)S-192 embryonic abdominal segment 6 (with Su(Tpl)17) Su(Tpl)S-192 Su(Tpl)s1 embryonic abdominal segment 6 (with Su(Tpl)s1) Su(Tpl)17 Su(Tpl)S-192 Su(Tpl)XS-706 embryonic abdominal segment 6 (with Su(Tpl)S-192) Su(Tpl)10 Su(Tpl)17 Su(Tpl)s1 embryonic abdominal segment 6 (with Su(Tpl)XS-706) Su(Tpl)s1 embryonic abdominal segment 8 (with Su(Tpl)s1) Su(Tpl)S-192 embryonic abdominal segment 8 (with Su(Tpl)S-192) Su(Tpl)s1 embryonic head (with Su(Tpl)10) Su(Tpl)S-192 embryonic head (with Su(Tpl)17) Su(Tpl)S-192 embryonic head (with Su(Tpl)S-192) Su(Tpl)10 Su(Tpl)17 embryonic mesothoracic segment (with Su(Tpl)S-192) Su(Tpl)XS-706 embryonic mesothoracic segment (with Su(Tpl)XS-706) Su(Tpl)S-192 embryonic metathoracic segment (with Su(Tpl)10) Su(Tpl)S-192 embryonic metathoracic segment (with Su(Tpl)S-192) Su(Tpl)10 Su(Tpl)XS-706 embryonic metathoracic segment (with Su(Tpl)XS-706) Su(Tpl)S-192 eye | somatic clone Su(Tpl)unspecified eye photoreceptor cell | somatic clone Su(Tpl)unspecified macrochaeta | somatic clone Su(Tpl)S-192 pigment cell | somatic clone Su(Tpl)unspecified tormogen cell | somatic clone Su(Tpl)S-192
Classical Alleles ( 31 )
For All Classical Alleles Show
Allele of Su(Tpl) Class Mutagen Stocks Known lesion Su(Tpl)10 ethyl methanesulfonate 2 Yes Su(Tpl)DG12505 P-element activity 1 -- Su(Tpl)DG14402 1 -- Su(Tpl)EY08138 1 Yes Su(Tpl)EY08696 P-element activity 1 Yes Su(Tpl)j3D4 P-element activity 1 Yes Su(Tpl)S-192 ethyl methanesulfonate 1 Yes Su(Tpl)17 ethyl methanesulfonate 0 Yes Su(Tpl)38 ethyl methanesulfonate 0 Yes Su(Tpl)CA06613 P-element activity 0 -- Su(Tpl)CPTI000232 piggyBac transposase 0 Yes Su(Tpl)CPTI000783 piggyBac transposase 0 Yes Su(Tpl)CPTI001018 piggyBac transposase 0 Yes Su(Tpl)CPTI001029 piggyBac transposase 0 Yes Su(Tpl)CPTI100008 piggyBac transposase 0 Yes Su(Tpl)DI998 X ray ethyl methanesulfonate 0 -- Su(Tpl)EP1113 P-element activity 0 Yes Su(Tpl)EP3-2015 0 Yes Su(Tpl)EZ1217 X ray ethyl methanesulfonate 0 -- Su(Tpl)J34 hypomorphic allele - genetic evidence PM hybrid dysgenesis 0 Yes Su(Tpl)J34R spontaneous 0 -- Su(Tpl)JE3 P-element activity 0 Yes Su(Tpl)JK58 P-element activity 0 -- Su(Tpl)S-705 0 -- Su(Tpl)S000606 Delta2-3 P-element activity 0 Yes Su(Tpl)S085401 Delta2-3 P-element activity 0 Yes Su(Tpl)s1 ethyl methanesulfonate 0 Yes Su(Tpl)s2 ethyl methanesulfonate 0 Yes Su(Tpl)s95 ethyl methanesulfonate X ray 0 -- Su(Tpl)unspecified ethyl methanesulfonate X ray 0 -- Su(Tpl)XS-706 X ray 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Su(Tpl) Class Mutagen Stocks Known lesion Su(Tpl)GD10818 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Su(Tpl)GL00168 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Su(Tpl)HMS00277 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Su(Tpl)KK101675 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Su(Tpl)Chi.T:Zzzz\His6,T:Zzzz\Xpress in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Su(Tpl)dsRNA.Sym.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Su(Tpl)hs.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)25-21 (Cooper et al., 2010) Df(3L)ash1A16 (Cooper et al., 2010) Df(3L)BSC2 (Bloomington Drosophila Stock Center, 1999.2.23, Cooper et al., 2010) Df(3L)BSC445 (Christensen et al., 2008.4.15, Cooper et al., 2010) Df(3L)ED4858 (Cooper et al., 2010) Df(3L)Exel9007 (Cooper et al., 2010) Df(3L)Exel9008 (Cooper et al., 2010) Df(3L)Exel9009 (Cooper et al., 2010) Df(3L)kto2 (Zhu et al., 2005, Dorer et al., 1995, Cooper et al., 2010) Df(3L)XS411 (Cooper et al., 2010) Df(3L)XS533 (Cooper et al., 2010) Df(3L)XS543 (Cooper et al., 2010) Df(3L)XS572 (Cooper et al., 2010) Df(3L)XS917 (Cooper et al., 2010) Df(3L)XS2182 (Cooper et al., 2010)
Not disrupted in	Df(3L)A23 (Cooper et al., 2010) Df(3L)BSC1 (Bloomington Drosophila Stock Center, 1999.2.23) Df(3L)BSC20 (Cooper et al., 2010) Df(3L)BSC417 (Cooper et al., 2010) Df(3L)ED228 (Cooper et al., 2010) Df(3L)ED4799 (Cooper et al., 2010) Df(3L)Exel6135 (Cooper et al., 2010) Df(3L)Exel9011 (Cooper et al., 2010) Df(3L)Exel9045 (Cooper et al., 2010) Df(3L)Exel9046 (Cooper et al., 2010) Df(3L)kto22 (Cooper et al., 2010) Df(3L)Pc-MK (Dorer et al., 1995) Df(3L)pipeA13 (Cooper et al., 2010) Df(3L)rdgC-co2 (Dorer et al., 1995) Df(3L)ri-79c (Dorer et al., 1995) Df(3L)VW3 (Dorer et al., 1995) Df(3L)XS705 (Cooper et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD10818} NA P{KK101675} NA P{Sym-UAS-Su(Tpl)} NA P{TRiP.GL00168} NA P{TRiP.HMS00277} NA characterization construct P{Chi-His6.Su(Tpl).Xpress} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Mi-2j3D4 No P{lacW}Mi-2S000606 No P{lacW}Mi-2S085401 No P{lacW}Su(Tpl)JK58 No insertion of mobile activating element P{EP}EP1113EP1113 NA P{EP}Su(Tpl)EP3-2015 NA P{EPgy2}Mi-2EY08696 NA P{EPgy2}Su(Tpl)EY08138 NA miscellaneous insertions P{}Su(Tpl)JE3 NA P{PTT-GA}Su(Tpl)CA06613 NA P{wHy}Mi-2DG14402 NA P{wHy}Su(Tpl)DG12505 NA PBac{566.P.SVS-1}Su(Tpl)CPTI100008 NA PBac{602.P.SVS-1}Su(Tpl)CPTI000232 NA PBac{602.P.SVS-1}Su(Tpl)CPTI000783 NA PBac{602.P.SVS-1}Su(Tpl)CPTI001018 NA PBac{602.P.SVS-1}Su(Tpl)CPTI001029 NA PBac{PB}Mi-2c00783 NA PBac{PB}Mi-2c03115 NA PBac{PB}Mi-2c05371 NA PBac{PB}Mi-2c06936 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
regulation of DNA-dependent transcription in response to stress inferred from mutant phenotype (Smith et al., 2008) wing disc dorsal/ventral pattern formation inferred from genetic interaction with Bx, ap (Bejarano et al., 2008)
Cellular Component
CV term Evidence References
polytene chromosome inferred from direct assay (Smith et al., 2008)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
transcription elongation from RNA polymerase II promoter inferred from electronic annotation with InterPro:IPR019464 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
transcription elongation factor complex inferred from electronic annotation with InterPro:IPR019464 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Su(Tpl) allele Gene References Su(Tpl)10 Tpl (Dorer et al., 1993, Dorer et al., 1995) Su(Tpl)17 ct (Eissenberg et al., 2002) Su(Tpl)DI998 aop (Rebay et al., 2000) Su(Tpl)EZ1217 aop (Rebay et al., 2000) Su(Tpl)J34 Tpl (Dorer et al., 1993, Dorer et al., 1995) Su(Tpl)s1 ct (Eissenberg et al., 2002) Su(Tpl)s95 sina (Neufeld et al., 1998) Su(Tpl)S-192 aop (Karim et al., 1996) ct (Eissenberg et al., 2002) Ras85D (Karim et al., 1996) sev (Maixner et al., 1998) Su(Tpl)S-705 sev (Maixner et al., 1998) Su(Tpl)unspecified sina (Neufeld et al., 1998) Su(Tpl)XS-706 aop (Karim et al., 1996) ct (Eissenberg et al., 2002) Ras85D (Karim et al., 1996)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65439 DroID - A comprehensive database of gene and protein interactions. • FBgn0014037 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40171
Orthologs
Genome-wide drosophilid orthologs	Dana\GF10841 Dgri\GH16905 Dmoj\GI13662 Dpse\GA23928 Dsec\GM15678 Dsim\GD12242 Dvir\GJ13997 Dwil\GK17503
Curated drosophilid orthologs	Dere\CG32217 (Comeron and Guthrie, 2005.7.21) Dpse\GA16762   Dsim\GD12242 (Comeron and Guthrie, 2005.7.21) Dyak\GE22457 (Comeron and Guthrie, 2005.7.21)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006021-PA Aedes aegypti (mosquito) AGAP004795-PA Anopheles gambiae (mosquito) XP_393419.2 Apis mellifera (honey bee) XP_001947940.1 Acyrthosiphon pisum (pea aphid) 95758 Branchiostoma floridae (lancelet) ENSBTAP00000009487 Bos taurus (bovine) ENSCAFP00000011681 Canis familiaris (dog) ENSCPOP00000014559 Cavia porcellus (guinea pig) ENSDARP00000093185 Danio rerio (zebra fish) ENSECAP00000020537 Equus caballus (horse) ENSGACP00000011771 Gymnopilus aculeatus (mushroom) ENSGALP00000005320 Gallus gallus (chicken) ENSGALP00000023605 Gallus gallus (chicken) ENSP00000237853 Homo sapiens (human) ENSMODP00000032312 Monodelphis domestica (gray opossum) ENSMMUP00000007031 Macaca mulatta (rhesus monkey) ENSMUSP00000001583 Mus musculus (house mouse) ENSOANP00000001926 Ornithorynchus anatinus (platypus) ENSORLP00000010842 Oryzias latipes (japanese killifish) ENSPPYP00000017492 Pongo pygmaeus (orangutan) 826946 Populus trichocarpa (black cottonwood) ENSPTRP00000029254 Pan troglodytes (chimpanzee) ENSRNOP00000035042 Rattus norvegicus (norway rat) Smp_092320.1 Schistosoma mansoni (trematode parasite) 60487 Trichoplax adhaerens (metazoa) XP_967115.2 Tribolium castaneum (red flour beetle) ENSTNIP00000013580 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000038344 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000057521 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV30014 NV23774 LH24256 LH24252 ISCW003949 FBgn0219502 FBgn0201215 FBgn0084820 FBgn0170594 JGI_V11_317377 JGI_V11_317378 FBgn0245327 FBgn0136417 FBgn0124376 FBgn0087881 CPIJ004404 BGIBMGA001447 ACYPI005599 GB16966 AGAP004795 AAEL006021 AAEL006015 PB20126 PB20127 PHUM019140 PHUM432210 GLEAN_02072
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	6562 Su(Tpl)S-192/TM3, P{sevRas1.V12}FK2, Sb1 33399 y1 sc* v1; P{TRiP.HMS00277}attP2 35270 y1 sc* v1; P{TRiP.GL00168}attP2/TM3, Sb1 207 Su(Tpl)10 kniri-1 Ki1 pp/TM3, Ser1 20602 y1 w67c23; P{wHy}Su(Tpl)DG12505 Mi-2DG12505 12106 y1 w*; P{lacW}Mi-2j3D4 Su(Tpl)j3D4/TM3, Sb1 Ser1 20417 y1 w67c23; P{wHy}Mi-2DG14402 Su(Tpl)DG14402/TM3, Sb1 Ser1 16876 y1 w67c23; P{EPgy2}Su(Tpl)EY08138 Mi-2EY08138/TM3, Sb1 Ser1 16905 y1 w67c23; P{EPgy2}Mi-2EY08696 Su(Tpl)EY08696/TM3, Sb1 Ser1
Kyoto	105788 Su(Tpl)10 kniri-1 Ki1 pp/TM3, Ser1
VDRC	v105657 P{KK101675}VIE-260B v34458 w1118; P{GD10818}v34458
Genomic Clones ( 1 )
	BACR13N10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 53 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT31092 LD12812 LD12841 LD19974
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09179 AT13157 AT22216 AT27234 GM02843 GM25948 LD03114 LD05359 LD16204 LD19019
Other clones	2266 9965 20775 28441 40045 54651 64621 67177 81277 100822 105298 175721 214437.53 214565.42 CK01.49D.G8 CK01.142D.G6 EK041360 EK116059 EK123359 EK126757 EK135259 EK136426 EK154243 EK166547 EK180024 EK195950 EK196509 EK214652 EK223421 EK243956 EP08210 EP14806 EP16026 FB59-CG32217-RA FGH103D12 FGM214B06 LD30320 UUGC0175 UUGC0210
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0014037 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40171 317921
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Ell CR32216 (FlyBase Genome Annotators, 2004) Source for merge of: Su(Tpl) l(3)76BDs SR3-4A (Eissenberg et al., 2002)
Additional comments	Annotations CG32217 (Su(Tpl)) and CR32216 merged as a single annotation in release 3.2 of the genome annotation (CR32216 corresponds to a 5' part of Su(Tpl)). (FlyBase Genome Annotators, 2004) Annotation CG8037 split into CR32218, CG32217 (Su(Tpl)) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003)
Other Comments
	New annotation (CR32216) in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Su(Tpl) is located in the largest intron of Mi-2, on the same strand. Overall orientation not stated: Mi-2+ Su(Tpl)+ Mi-2+ (Khattak et al., 2002) Heat shock induces relocalization of Su(Tpl) protein to activated heat shock genes. (Gerber et al., 2001) Su(Tpl) functions with elongating RNA polymerase II in vivo. (Gerber et al., 2001) 24 "SS3-4" alleles of Su(Tpl) have been isolated in a screen for dominant modifiers of the sinaGMR.PN eye phenotype. (Neufeld et al., 1998) Identified on the basis of genetic interaction with Ras85DV12.sev. (Karim et al., 1996) Su(Tpl) mutations suppress the lethality associated with three copies of the Tpl locus and are themselves recessive lethal. (Dorer et al., 1995) Mutations at Su(Tpl) block the triplo-lethal effect of Tpl. Several alleles previously thought to be hypomorphic mutations of Tpl are dominant mutations of the linked Su(Tpl). Su(Tpl) mutations are recessive lethal. (Dorer et al., 1993) Record revised by Alan Christensen, 19 January 1996.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_140898 NM_001170006 RefSeq (Proteins) • NP_649155 NP_001163477 DDBJ / EMBL / GenBank • AA392430 AAF49098 AAL13036 AAL28709 ABA86454 ACZ94748 AF416770 AQ026314 AW942250 AY061161 CL528124 DQ138848 Entrez Gene - A searchable database of RefSeq genes. • 40171 UniProtKB/TrEMBL • Q2XY14 Q9VW51 Q95RS9 Q95SC1 Q95VE6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Occludin/RNA polymerase II elongation factor, ELL domain (IPR010844) RNA polymerase II elongation factor ELL (IPR019464)
Linkouts
	BioGRID - A database of protein and genetic interactions • 65439 DroID - A comprehensive database of gene and protein interactions. • FBgn0014037 DRSC - Results from RNAi screens. • FBgn0014037 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014037 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32217-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0014037 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40171 317921 InParanoid A subset of ortholog calls from InParanoid. • AAEL006021-PA Aedes aegypti (mosquito) AGAP004795-PA Anopheles gambiae (mosquito) XP_393419.2 Apis mellifera (honey bee) XP_001947940.1 Acyrthosiphon pisum (pea aphid) 95758 Branchiostoma floridae (lancelet) ENSBTAP00000009487 Bos taurus (bovine) ENSCAFP00000011681 Canis familiaris (dog) ENSCPOP00000014559 Cavia porcellus (guinea pig) ENSDARP00000093185 Danio rerio (zebra fish) ENSECAP00000020537 Equus caballus (horse) ENSGACP00000011771 Gymnopilus aculeatus (mushroom) ENSGALP00000005320 Gallus gallus (chicken) ENSGALP00000023605 Gallus gallus (chicken) ENSP00000237853 Homo sapiens (human) ENSMODP00000032312 Monodelphis domestica (gray opossum) ENSMMUP00000007031 Macaca mulatta (rhesus monkey) ENSMUSP00000001583 Mus musculus (house mouse) ENSOANP00000001926 Ornithorynchus anatinus (platypus) ENSORLP00000010842 Oryzias latipes (japanese killifish) ENSPPYP00000017492 Pongo pygmaeus (orangutan) 826946 Populus trichocarpa (black cottonwood) ENSPTRP00000029254 Pan troglodytes (chimpanzee) ENSRNOP00000035042 Rattus norvegicus (norway rat) Smp_092320.1 Schistosoma mansoni (trematode parasite) 60487 Trichoplax adhaerens (metazoa) XP_967115.2 Tribolium castaneum (red flour beetle) ENSTNIP00000013580 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000038344 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000057521 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40171 modMine - Data generated by the modENCODE project. • FBgn0014037 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV30014 NV23774 LH24256 LH24252 ISCW003949 FBgn0219502 FBgn0201215 FBgn0084820 FBgn0170594 JGI_V11_317377 JGI_V11_317378 FBgn0245327 FBgn0136417 FBgn0124376 FBgn0087881 CPIJ004404 BGIBMGA001447 ACYPI005599 GB16966 AGAP004795 AAEL006021 AAEL006015 PB20126 PB20127 PHUM019140 PHUM432210 GLEAN_02072
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	0854/01 (Deak et al., 1997) CG8037   CG32217 (Molnar et al., 2006, Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Ling and Salvaterra, 2011, Ni et al., 2011.7.19) CR32216   dELL (Sims et al., 2004, Eissenberg et al., 2002, Khattak et al., 2002, Gerber et al., 2001, Gerber et al., 2005, Bejarano et al., 2008, Smith et al., 2008, Lin et al., 2010) ELL (Gerber and Shilatifard, 2003, Gerber, 2001.9.4, Eissenberg et al., 2007, Smith et al., 2008, Lin et al., 2010) Ell (Orian et al., 2003, Giot et al., 2003, ) l (3)76BD (Gerber et al., 2005) l(3)76BDs (Zhu et al., 2005, Eissenberg et al., 2002, Kehle et al., 1998, Cooper et al., 2010) l(3)S000606   l(3)S085401 (Szeged Stock Center, 1998-, ) SR3-4A (Eissenberg et al., 2002, Maixner et al., 1998, Karim et al., 1996, Gerber et al., 2005) SS3-4 (Neufeld et al., 1998) Su(Tpl) (Buszczak et al., 2007, Christensen et al., 2008.4.15, Bejarano et al., 2008, Zhou et al., 2008, Cooper et al., 2010, Beckstead et al., 2007, Ling and Salvaterra, 2011) SY3-1 (Rebay et al., 2000, Gerber et al., 2005)
Name Synonym	elongation factor RNA polymerase II (Ling and Salvaterra, 2011) Su(Tpl)   Suppressor of GMR-sina 3-4 (Neufeld et al., 1998) Suppressor of Triplolethal (Shalaby et al., 2009)
Secondary FlyBase IDs
	FBgn0016733 FBgn0025923 FBgn0028080 FBgn0028245 FBgn0028435 FBgn0036914 FBgn0052216 FBgn0052217
References ( 70 )
Generate a list of	All references relating to this gene ( 70 )
List References by type	Research paper  ( 33 ) Supplementary material  ( 3 ) Review  ( 2 ) Personal communication to FlyBase  ( 14 ) Abstract  ( 4 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 4 ) Computer file  ( 3 ) Book  ( 1 ) Automatic genome annotation  ( 2 )
Recent research papers ( 4 )
	Ling and Salvaterra, 2011, PLoS ONE 6(3): e17762 Robust RT-qPCR Data Normalization: Validation and Selection of Internal Reference Genes during Post-Experimental Data Analysis. [FBrf0213272] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Cooper et al., 2010, Genetics 185(3): 811--822 Molecular Genetic Analysis of Chd3 and Polytene Chromosome Region 76B-D in Drosophila melanogaster. [FBrf0211329] Lin et al., 2010, Mol. Cell 37(3): 429--437 AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. [FBrf0214890] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...