A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\bnl

General Information
SymbolDmel\bnlSpeciesD. melanogaster
NamebranchlessAnnotation symbolCG4608
Feature typeprotein_coding_geneFlyBase IDFBgn0014135
Created / Updated2005-01-10/2005-01-10
Genomic Location
Chromosome (arm)3RRecombination map
Cytogenetic map92B2-92B3Sequence location3R:15,619,795..15,662,539 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene branchless is referred to in FlyBase by the symbol bnl (CG4608, FBgn0014135). It has the cytological map location 92B2-92B3. Its sequence location is 3R:15619795..15662539. Its molecular function is described as: fibroblast growth factor receptor binding; growth factor activity. It is involved in the biological processes described with 14 unique terms, many of which group under: anatomical structure development; open tracheal system development; morphogenesis of a branching structure; system development; taxis; locomotory behavior; cell projection organization and biogenesis; tube morphogenesis; response to chemical stimulus; transmembrane receptor protein tyrosine kinase signaling pathway; cell morphogenesis. 18 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; embryonic/larval tracheal system; tracheal system; trachea; anatomical structure; embryonic/larval dorsal branch; adult tracheal system; dorsal thoracic disc; embryonic ganglionic branch; adult trachea; thoracic segment. It has 2 annotated transcripts and 2 annotated polypeptides.

External Summaries
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
92B2-92B3  
Limits computationally determined from genome sequence between P{EP}EP650 and P{PZ}l(3)1058510585  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
92B2-92B3
(determined by in situ hybridisation)  
92B-92B
(determined by in situ hybridisation)  
92B-92B
(determined by in situ hybridisation)  
92B-92B
(determined by in situ hybridisation) 92B2--3 (determined by in situ hybridisation)  
92B-92B
(determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\bnl for information on other features
detailed view FBtr0300123 FBtr0083795 FBpp0289400 FBpp0083206 FBti0055082 FBti0020879 FBti0048099 FBti0066473 FBti0065105 FBti0004145 FBti0050257 FBti0028876 FBti0069301 FBti0059147 FBti0028384 FBti0005050 FBti0035487 FBti0029750 FBti0029518 FBti0058960 FBti0069404 FBti0029401 FBti0028701 FBti0028266 FBti0100882 FBti0069233 FBti0059373 FBti0030118 FBti0059412 FBti0070224 FBti0034697 FBti0069251 FBti0029639 FBti0029655 FBti0070424 FBti0029342 FBti0070398 FBti0030116 FBti0029651 FBti0029090 FBti0055678 FBti0056803 FBti0028133 FBti0100893 FBti0100796 FBti0040283 FBti0029718 FBti0100140 FBti0004144 FBti0047907
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0083795
  3632
  770
FBtr0300123
 
  4295
  760
Additional Transcript Data & Comments
Reported size (kB)
4 (northern blot)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
bnl-PA  
FBpp0083206  
84.1  
770  
9.97  
bnl-PC  
FBpp0289400  
82.9  
760  
9.97  
 
 
Additional Polypeptide Data & Comments
Reported size (kD)
770 (aa); 84 (kD predicted)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data
    Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
     embryonic stage
     cephalic furrow
     embryonic stage
     posterior transverse furrow
     embryonic stage | stage >=11
     tracheal air sac | surrounding
     embryonic stage
     larval stage | third instar
     dorsal mesothoracic disc | anterior/posterior compartment boundary & vicinity of & dorsal & restricted
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0300123 FBtr0083795
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        FlyExpress - Embryonic expression images (BDGP data)
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        Phenotype manifest in
        Allele
        air sac tracheoblast of dorsal mesothoracic disc & filopodium | somatic clone | cell non-autonomous
        tracheal metamere 1 & embryo
        tracheal metamere 2 & embryo
        tracheal metamere 3 & embryo
        tracheal metamere 4 & embryo
        tracheal metamere 5 & embryo
        tracheal metamere 6 & embryo
        tracheal metamere 7 & embryo
        tracheal metamere 8 & embryo
        tracheal metamere 9 & embryo
        tracheal metamere 10 & embryo
        embryonic tracheal system & filopodium | ectopic, with Scer\GAL4btl.PS
        tracheal tip cell & embryo, with Scer\GAL4hs.PB
        air sac tracheoblast of dorsal mesothoracic disc & filopodium
        hide Classical Alleles ( 12 )
        For All Classical Alleles Show

        Allele of bnlClassMutagenStocksKnown lesion
        bnl00857amorph, loss of function1 Yes
        bnl06916hypomorph1 Yes
        bnl7080 --
        bnlKG001571 --
        bnlPL007900 Yes
        bnlS0440261 --
        bnlc019390 --
        bnle000290 --
        bnle031151 --
        bnlf018681 --
        bnlneo521 --
        bnlunspecified
          0 --
          hide Alleles Carried on Transgenic Constructs ( 6 )
          For All Alleles Carried on Transgenic Constructs Show

          Allele of bnlClassMutagenStocksKnown lesion
          bnlGD30702 Yes
          bnlScer\FRT.Disc\RFP-DsRed2.y.αTub84B0 Yes
          bnlScer\UAS.P\T.cRa0 Yes
          bnlScer\UAS.cSa0 --
          bnlhs.PS0 Yes
          bnlαTub84B.PS0 Yes
          hide Aneuploid Aberrations
          Useful deficiency
          Useful duplication
          Disrupted in
          Not disrupted in
          hide Transgenic Constructs & Insertions
          Transgenic Constructs
          Type of construct
          Name
          Expression data
          UAS construct
          heat-shock construct
          Insertions
          Type of insertions
          Name
          Expression data
          insertion of enhancer trap binary system
          insertion of enhancer trap
          insertion of mobile activating element
          hide Related Comments
          Please look at the allele reports for the complete phenotype data
          RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
          hide Gene Ontology: Function, Process & Cellular Component ( 17 )
          hide Molecular Function
          CV term
          References
          non-traceable author statement
          inferred from sequence or structural similarity with MGD:Fgf10; MGI:MGI:1099809
          traceable author statement
          traceable author statement
          traceable author statement
          traceable author statement
          inferred from electronic annotation with InterPro:IPR002209, InterPro:IPR002348
          hide Biological Process
          CV term
          References
          traceable author statement
          inferred from direct assay
          traceable author statement
          traceable author statement
          traceable author statement
          traceable author statement
          traceable author statement
          traceable author statement
          non-traceable author statement
          traceable author statement
          traceable author statement
          inferred from mutant phenotype
          inferred from expression pattern
          traceable author statement
          non-traceable author statement
          traceable author statement
          inferred from mutant phenotype
          inferred from direct assay
          traceable author statement
          traceable author statement
          traceable author statement
          traceable author statement
          traceable author statement
          traceable author statement
          traceable author statement
          traceable author statement
          traceable author statement
          hide Cellular Component
          CV term
          References
          inferred from sequence or structural similarity
          inferred from sequence or structural similarity
          hide Sequence Ontology: Class of Gene
          hide Interactions & Pathways
          hide Summary of Genetic Interactions
          Interacts with
          Please look at the allele data for full details of the genetic interactions
          bnl allele
          Gene
          References
          hide External Data
          Linkouts
          BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
          hide Orthologs
          Genome-wide drosophilid orthologs
          Curated drosophilid orthologs
          Linkouts
          InParanoid orthologs - Eukaryotic orthologs