UAP56, WM6, hel, l(2)gdh-12, jf26
Gene model reviewed during 5.45
Low-frequency RNA-Seq exon junction(s) not annotated.
Component of the spliceosome (Probable). Interacts with the exon junction complex.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hel25E using the Feature Mapper tool.
In the larval salivary gland, Hel25E protein associates with the polytene chromosomes. In ovaries, staining is seen in nurse cell and follicle cell nuclei. Confocal microscopy of cycle 14 embyros double-labeled with antibodies against Hel25E and betaTub60D shows that Hel25E disappears from within mitotic domains, although it is present in the nuclei of the other cells at the surface of the embryo.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Hel25E in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Hel25E CG7269
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in chromosome misalignment on the metaphase spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells.
Hel25E encodes a putative RNA helicase that contains an unusual variant (DECD) of the DEAD motif common to these proteins.