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Gene Dmel\prod

General Information
Symbol	Dmel\prod	Species	D. melanogaster
Name	proliferation disrupter	Annotation symbol	CG18608
Feature type	protein_coding_gene	FlyBase ID	FBgn0014269
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	l(2)88/10
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	56A2-56A2	Sequence location	2R:14,856,910..14,858,656 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene proliferation disrupter is referred to in FlyBase by the symbol Dmel\prod (CG18608, FBgn0014269). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: chromatin binding. There is experimental evidence that it is involved in the biological process: lymph gland development; regulation of circadian rhythm. 13 alleles are reported. The phenotypes of these alleles are annotated with: eye-antennal disc; embryonic/larval lymph gland; eye; imaginal disc; embryonic/larval brain. It has one annotated transcript and one annotated polypeptide. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult salivary gland, larval trachea, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1623239_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of prod. Gene sequence location is 2R:14856910..14858656.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN25321 HFA07667
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 56A2-56A2   Limits computationally determined from genome sequence between P{PZ}l(2)0370903709 and P{lacW}prodk08810
Experimentally Determined Cytological Location
Cytogenetic map Notes References 56A-56A     (Itoh, 1998.10.19) 56A-56A     (Torok, 1997.1.2) 56A-56A     (Itoh, 1999.1.6) 56A1-56A2   (determined by in situ hybridisation)   (Spradling et al., 1999) 56A1-56A2     (BDGP Project Members, 1994-1999) 56A-56A   (determined by in situ hybridisation)   (Torok et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\prod for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) prod-RA FBtr0086601  NM_166317   1614   346
Additional Transcript Data & Comments
Reported size (kB)	1.6, 1.4 (northern blot) (Torok et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein prod-PA   FBpp0085785   39.4   346   4.96     NP_725841   AAF57616
Additional Polypeptide Data & Comments
Reported size (kDa)	346 (aa); 34.3 (kD observed) (Torok et al., 1997)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201372   AA203086   AA246560   AA247080   AA264933   AA390916   AA695080   AA941445   AA948892   AA951195   AE013599 AAF57616   AB018793   AB018794 BAA76307   AB022040 BAA82621   AI295060   AI403875   AI515424   AI515891   AI531316   AI531325   AI544148   AQ025870   AQ073584   AW944232   AY058757 AAL13986   BF501796   BI229298   BI240558   BI362336   CL844456   CO288598   CO307059   CZ467448   EC064323   EC066071   EC081579   EC197842   U83596 AAC32727
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KYA8 Q7KYD3 Q7JNE1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Torok et al., 1997)
Additional Descriptive Data
	The 1.6 kb prod transcript is expressed at high levels in all stages tested. (Torok et al., 1997) The 1.4 kb prod transcript is expressed weakly in all stages except for early embryos where it is not detected. (Torok et al., 1997)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Torok et al., 1997) larval stage   organism | ubiquitous   (Torok et al., 1997) adult stage   organism | ubiquitous   (Torok et al., 1997)
Additional Descriptive Data
	prod protein is ubiquitous in embryos, larvae, and adults. The protein is highly concentrated in the centric heterochromatin of second and third mitotic chromosomes. In salivary gland chromosomes, more than 400 euchromatic sites are stained, but the chromocenter remains unstained. (Torok et al., 1997)
Marker for
Subcellular Localization
CV Term	nucleus centric heterochromatin polytene chromosome (Torok et al., 1997)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0014269    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0014269 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0014269 expression level Developmental Stage   Expression Level embryo 00-02hr    6151 embryo 02-04hr    8866 embryo 04-06hr    8436 embryo 06-08hr    9089 embryo 08-10hr    7355 embryo 10-12hr    5612 embryo 12-14hr    3245 embryo 14-16hr    3665 embryo 16-18hr    2530 embryo 18-20hr    1423 embryo 20-22hr    2862 embryo 22-24hr    1878 larva L1    1170 larva L2    921 larva L3 12hr old    746 larva L3 puffstage 1-2    872 larva L3 puffstage 3-6    1351 larva L3 puffstage 7-9    1573 white prepupae new    1566 white prepupae 12hr    1889 white prepupae 24hr    2130 pupae 2d postWPP    1384 pupae 3d postWPP    1022 pupae 4d postWPP    831 adult male 01day    915 adult male 05day    1083 adult male 30day    1118 adult female 01day    1888 adult female 05day    2447 adult female 30day    2675 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6151) embryo 02-04hr  (8866) embryo 04-06hr  (8436) embryo 06-08hr  (9089) embryo 08-10hr  (7355) embryo 10-12hr  (5612) embryo 12-14hr  (3245) embryo 14-16hr  (3665) embryo 16-18hr  (2530) embryo 18-20hr  (1423) embryo 20-22hr  (2862) embryo 22-24hr  (1878) larva L1  (1170) larva L2  (921) larva L3 12hr old  (746) larva L3 puffstage 1-2  (872) larva L3 puffstage 3-6  (1351) larva L3 puffstage 7-9  (1573) white prepupae new  (1566) white prepupae 12hr  (1889) white prepupae 24hr  (2130) pupae 2d postWPP  (1384) pupae 3d postWPP  (1022) pupae 4d postWPP  (831) adult male 01day  (915) adult male 05day  (1083) adult male 30day  (1118) adult female 01day  (1888) adult female 05day  (2447) adult female 30day  (2675) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6151) embryo 02-04hr  (8866) embryo 04-06hr  (8436) embryo 06-08hr  (9089) embryo 08-10hr  (7355) embryo 10-12hr  (5612) embryo 12-14hr  (3245) embryo 14-16hr  (3665) embryo 16-18hr  (2530) embryo 18-20hr  1423 embryo 20-22hr  (2862) embryo 22-24hr  (1878) larva L1    1170 larva L2    921 larva L3 12hr old    746 larva L3 puffstage 1-2    872 larva L3 puffstage 3-6    1351 larva L3 puffstage 7-9  (1573) white prepupae new  (1566) white prepupae 12hr  (1889) white prepupae 24hr  (2130) pupae 2d postWPP    1384 pupae 3d postWPP    1022 pupae 4d postWPP    831 adult male 01day    915 adult male 05day    1083 adult male 30day    1118 adult female 01day  (1888) adult female 05day  (2447) adult female 30day  (2675) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6151 embryo 02-04hr    8866 embryo 04-06hr    8436 embryo 06-08hr    9089 embryo 08-10hr    7355 embryo 10-12hr    5612 embryo 12-14hr    3245 embryo 14-16hr    3665 embryo 16-18hr    2530 embryo 18-20hr    1423 embryo 20-22hr    2862 embryo 22-24hr    1878 larva L1    1170 larva L2    921 larva L3 12hr old    746 larva L3 puffstage 1-2    872 larva L3 puffstage 3-6    1351 larva L3 puffstage 7-9    1573 white prepupae new    1566 white prepupae 12hr    1889 white prepupae 24hr    2130 pupae 2d postWPP    1384 pupae 3d postWPP    1022 pupae 4d postWPP    831 adult male 01day    915 adult male 05day    1083 adult male 30day    1118 adult female 01day    1888 adult female 05day    2447 adult female 30day    2675 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6151 embryo 02-04hr    8866 embryo 04-06hr    8436 embryo 06-08hr    9089 embryo 08-10hr    7355 embryo 10-12hr    5612 embryo 12-14hr    3245 embryo 14-16hr    3665 embryo 16-18hr    2530 embryo 18-20hr    1423 embryo 20-22hr    2862 embryo 22-24hr    1878 larva L1    1170 larva L2    921 larva L3 12hr old    746 larva L3 puffstage 1-2    872 larva L3 puffstage 3-6    1351 larva L3 puffstage 7-9    1573 white prepupae new    1566 white prepupae 12hr    1889 white prepupae 24hr    2130 pupae 2d postWPP    1384 pupae 3d postWPP    1022 pupae 4d postWPP    831 adult male 01day    915 adult male 05day    1083 adult male 30day    1118 adult female 01day    1888 adult female 05day    2447 adult female 30day    2675 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0014269 expression level Developmental Stage   Expression Level embryo 00-02hr    6151 embryo 02-04hr    8866 embryo 04-06hr    8436 embryo 06-08hr    9089 embryo 08-10hr    7355 embryo 10-12hr    5612 embryo 12-14hr    3245 embryo 14-16hr    3665 embryo 16-18hr    2530 embryo 18-20hr    1423 embryo 20-22hr    2862 embryo 22-24hr    1878 larva L1    1170 larva L2    921 larva L3 12hr old    746 larva L3 puffstage 1-2    872 larva L3 puffstage 3-6    1351 larva L3 puffstage 7-9    1573 white prepupae new    1566 white prepupae 12hr    1889 white prepupae 24hr    2130 pupae 2d postWPP    1384 pupae 3d postWPP    1022 pupae 4d postWPP    831 adult male 01day    915 adult male 05day    1083 adult male 30day    1118 adult female 01day    1888 adult female 05day    2447 adult female 30day    2675 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (6151) embryo 02-04hr  (8866) embryo 04-06hr  (8436) embryo 06-08hr  (9089) embryo 08-10hr  (7355) embryo 10-12hr  (5612) embryo 12-14hr  (3245) embryo 14-16hr  (3665) embryo 16-18hr  (2530) embryo 18-20hr  (1423) embryo 20-22hr  (2862) embryo 22-24hr  (1878) larva L1  (1170) larva L2  (921) larva L3 12hr old  (746) larva L3 puffstage 1-2  (872) larva L3 puffstage 3-6  (1351) larva L3 puffstage 7-9  (1573) white prepupae new  (1566) white prepupae 12hr  (1889) white prepupae 24hr  (2130) pupae 2d postWPP  (1384) pupae 3d postWPP  (1022) pupae 4d postWPP  (831) adult male 01day  (915) adult male 05day  (1083) adult male 30day  (1118) adult female 01day  (1888) adult female 05day  (2447) adult female 30day  (2675) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (6151) embryo 02-04hr  (8866) embryo 04-06hr  (8436) embryo 06-08hr  (9089) embryo 08-10hr  (7355) embryo 10-12hr  (5612) embryo 12-14hr  (3245) embryo 14-16hr  (3665) embryo 16-18hr  (2530) embryo 18-20hr  1423 embryo 20-22hr  (2862) embryo 22-24hr  1878 larva L1    1170 larva L2    921 larva L3 12hr old    746 larva L3 puffstage 1-2    872 larva L3 puffstage 3-6    1351 larva L3 puffstage 7-9  1573 white prepupae new  1566 white prepupae 12hr  1889 white prepupae 24hr  2130 pupae 2d postWPP    1384 pupae 3d postWPP    1022 pupae 4d postWPP    831 adult male 01day    915 adult male 05day    1083 adult male 30day    1118 adult female 01day  1888 adult female 05day  2447 adult female 30day  (2675) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    6151 embryo 02-04hr    8866 embryo 04-06hr    8436 embryo 06-08hr    9089 embryo 08-10hr    7355 embryo 10-12hr    5612 embryo 12-14hr    3245 embryo 14-16hr    3665 embryo 16-18hr    2530 embryo 18-20hr    1423 embryo 20-22hr    2862 embryo 22-24hr    1878 larva L1    1170 larva L2    921 larva L3 12hr old    746 larva L3 puffstage 1-2    872 larva L3 puffstage 3-6    1351 larva L3 puffstage 7-9    1573 white prepupae new    1566 white prepupae 12hr    1889 white prepupae 24hr    2130 pupae 2d postWPP    1384 pupae 3d postWPP    1022 pupae 4d postWPP    831 adult male 01day    915 adult male 05day    1083 adult male 30day    1118 adult female 01day    1888 adult female 05day    2447 adult female 30day    2675 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    6151 embryo 02-04hr    8866 embryo 04-06hr    8436 embryo 06-08hr    9089 embryo 08-10hr    7355 embryo 10-12hr    5612 embryo 12-14hr    3245 embryo 14-16hr    3665 embryo 16-18hr    2530 embryo 18-20hr    1423 embryo 20-22hr    2862 embryo 22-24hr    1878 larva L1    1170 larva L2    921 larva L3 12hr old    746 larva L3 puffstage 1-2    872 larva L3 puffstage 3-6    1351 larva L3 puffstage 7-9    1573 white prepupae new    1566 white prepupae 12hr    1889 white prepupae 24hr    2130 pupae 2d postWPP    1384 pupae 3d postWPP    1022 pupae 4d postWPP    831 adult male 01day    915 adult male 05day    1083 adult male 30day    1118 adult female 01day    1888 adult female 05day    2447 adult female 30day    2675 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0014269    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0014269 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval/adult salivary gland, larval trachea, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0014269 expression level Tissue   Expression Level Larval Central Nervous System    211.05 Larval Midgut    63.2 Larval Hindgut    88.8 Larval Malpighian Tubules    62.7 Larval Fat Body    56 Larval Salivary Gland    136.9 Larval Trachea    107.55 Larval Carcass    86.525 Adult Head    87.9 Adult Eye    85.775 Adult Brain    125 Adult Thoracic-Abdominal Ganglion    92.2 Adult Crop    99.3 Adult Midgut    76.3 Adult Hindgut    84.1 Adult Malpighian Tubules    54.9 Adult Fat Body    62.9 Adult Salivary Gland    134.5 Adult Heart    60.775 Adult VirginFemale Spermatheca    38.1 Adult InseminatedFemale Spermatheca    46.5 Adult Ovary    219.5 Adult Testis    66 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    211.05 Larval Midgut    63.2 Larval Hindgut    88.8 Larval Malpighian Tubules    62.7 Larval Fat Body    56 Larval Salivary Gland    136.9 Larval Trachea    107.55 Larval Carcass    86.525 Adult Head    87.9 Adult Eye    85.775 Adult Brain    125 Adult Thoracic-Abdominal Ganglion    92.2 Adult Crop    99.3 Adult Midgut    76.3 Adult Hindgut    84.1 Adult Malpighian Tubules    54.9 Adult Fat Body    62.9 Adult Salivary Gland    134.5 Adult Heart    60.775 Adult VirginFemale Spermatheca    38.1 Adult InseminatedFemale Spermatheca    46.5 Adult Ovary    219.5 Adult Testis    66 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    211.05 Larval Midgut    63.2 Larval Hindgut    88.8 Larval Malpighian Tubules    62.7 Larval Fat Body    56 Larval Salivary Gland    136.9 Larval Trachea    107.55 Larval Carcass    86.525 Adult Head    87.9 Adult Eye    85.775 Adult Brain    125 Adult Thoracic-Abdominal Ganglion    92.2 Adult Crop    99.3 Adult Midgut    76.3 Adult Hindgut    84.1 Adult Malpighian Tubules    54.9 Adult Fat Body    62.9 Adult Salivary Gland    134.5 Adult Heart    60.775 Adult VirginFemale Spermatheca    38.1 Adult InseminatedFemale Spermatheca    46.5 Adult Ovary    219.5 Adult Testis    66 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    211.05 Larval Midgut    63.2 Larval Hindgut    88.8 Larval Malpighian Tubules    62.7 Larval Fat Body    56 Larval Salivary Gland    136.9 Larval Trachea    107.55 Larval Carcass    86.525 Adult Head    87.9 Adult Eye    85.775 Adult Brain    125 Adult Thoracic-Abdominal Ganglion    92.2 Adult Crop    99.3 Adult Midgut    76.3 Adult Hindgut    84.1 Adult Malpighian Tubules    54.9 Adult Fat Body    62.9 Adult Salivary Gland    134.5 Adult Heart    60.775 Adult VirginFemale Spermatheca    38.1 Adult InseminatedFemale Spermatheca    46.5 Adult Ovary    219.5 Adult Testis    66 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0014269 expression level Tissue   Expression Level Larval Central Nervous System    211.05 Larval Midgut    63.2 Larval Hindgut    88.8 Larval Malpighian Tubules    62.7 Larval Fat Body    56 Larval Salivary Gland    136.9 Larval Trachea    107.55 Larval Carcass    86.525 Adult Head    87.9 Adult Eye    85.775 Adult Brain    125 Adult Thoracic-Abdominal Ganglion    92.2 Adult Crop    99.3 Adult Midgut    76.3 Adult Hindgut    84.1 Adult Malpighian Tubules    54.9 Adult Fat Body    62.9 Adult Salivary Gland    134.5 Adult Heart    60.775 Adult VirginFemale Spermatheca    38.1 Adult InseminatedFemale Spermatheca    46.5 Adult Ovary    219.5 Adult Testis    66 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    211.05 Larval Midgut    63.2 Larval Hindgut    88.8 Larval Malpighian Tubules    62.7 Larval Fat Body    56 Larval Salivary Gland    136.9 Larval Trachea    107.55 Larval Carcass    86.525 Adult Head    87.9 Adult Eye    85.775 Adult Brain    125 Adult Thoracic-Abdominal Ganglion    92.2 Adult Crop    99.3 Adult Midgut    76.3 Adult Hindgut    84.1 Adult Malpighian Tubules    54.9 Adult Fat Body    62.9 Adult Salivary Gland    134.5 Adult Heart    60.775 Adult VirginFemale Spermatheca    38.1 Adult InseminatedFemale Spermatheca    46.5 Adult Ovary    219.5 Adult Testis    66 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    211.05 Larval Midgut    63.2 Larval Hindgut    88.8 Larval Malpighian Tubules    62.7 Larval Fat Body    56 Larval Salivary Gland    136.9 Larval Trachea    107.55 Larval Carcass    86.525 Adult Head    87.9 Adult Eye    85.775 Adult Brain    125 Adult Thoracic-Abdominal Ganglion    92.2 Adult Crop    99.3 Adult Midgut    76.3 Adult Hindgut    84.1 Adult Malpighian Tubules    54.9 Adult Fat Body    62.9 Adult Salivary Gland    134.5 Adult Heart    60.775 Adult VirginFemale Spermatheca    38.1 Adult InseminatedFemale Spermatheca    46.5 Adult Ovary    219.5 Adult Testis    66 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    211.05 Larval Midgut    63.2 Larval Hindgut    88.8 Larval Malpighian Tubules    62.7 Larval Fat Body    56 Larval Salivary Gland    136.9 Larval Trachea    107.55 Larval Carcass    86.525 Adult Head    87.9 Adult Eye    85.775 Adult Brain    125 Adult Thoracic-Abdominal Ganglion    92.2 Adult Crop    99.3 Adult Midgut    76.3 Adult Hindgut    84.1 Adult Malpighian Tubules    54.9 Adult Fat Body    62.9 Adult Salivary Gland    134.5 Adult Heart    60.775 Adult VirginFemale Spermatheca    38.1 Adult InseminatedFemale Spermatheca    46.5 Adult Ovary    219.5 Adult Testis    66 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    87.9   NA  Eye    85.775   NA  Brain    125   211.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    92.2   NA  Crop    99.3   63.2  Midgut    76.3   88.8  Hindgut    84.1   62.7  Malpighian Tubules    54.9   56  Fat Body    62.9   136.9  Salivary Gland    134.5   NA  Heart    60.775   107.55  Trachea    NA   NA  VirginFemale Spermatheca    38.1   NA  InseminatedFemale Spermatheca    46.5   NA  Ovary    219.5   NA  Testis    66   NA  Male Accessory Gland    no informative data   86.525  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014269 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18608-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for prod Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4hs.PB prodScer\UAS.cTa lethal | larval stage prodk08810 lethal | larval stage | recessive prodAA prodk08810 lethal | recessive prodk08810 viable prodEY11391 viable | partially prodK Sterility Allele fertile prodEY11391 semi-sterile, with Scer\GAL4hs.PB prodScer\UAS.cTa Other Phenotypes Allele hyperplasia prodk08810 locomotor rhythm defective, with Scer\GAL4tim.Scer\UAS proddsRNA.Scer\UAS visible, with Scer\GAL4hs.PB prodScer\UAS.cTa wild-type prod+t8 Phenotype manifest in Allele adult cuticle | somatic clone prodk08810 embryonic/larval brain prodk08810 embryonic/larval lymph gland prodk08810 eye, with Scer\GAL4hs.PB prodScer\UAS.cTa eye-antennal disc prodk08810 imaginal disc prodk08810 leg & adult cuticle | somatic clone prodk08810 leg & macrochaeta | somatic clone prodk08810 macrochaeta | somatic clone prodk08810 mitosis & nuclear chromosome prodk08810
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of prod Class Mutagen Stocks Known lesion prodk08810 loss of function allele P-element activity 2 Yes prodc01787 piggyBac transposase 1 -- prodEY11391 P-element activity 1 -- prodAA Delta2-3 0 Yes prodEP2435 P-element activity 0 -- prodK Delta2-3 0 Yes produnspecified 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of prod Class Mutagen Stocks Known lesion prodKK104361 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes prod+t5.1 in vitro construct - genomic fragment 0 Yes prod+t8 in vitro construct - genomic fragment 0 Yes proddsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes prodGD9618 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes prodScer\UAS.cTa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6068 (Ryder, 2004.4.26) Df(2R)P34 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)rib-ex12 (Shim et al., 2001)
Not disrupted in	Df(2R)PC29 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Beaton, 1997.3.4)
Partially disrupted in	Df(2R)ToporsAA (Secombe and Parkhurst, 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9618} NA P{KK104361} NA P{UAS-prod.IR} NA P{UAS-prod.T} NA characterization construct P{prod+t5.1} NA P{UZ.prod} NA P{XhoI-HindIII} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}prodk08810 No insertion of mobile activating element P{EP}prodEP2435 NA P{EPgy2}prodEY11391 NA miscellaneous insertions PBac{PB}prodc01787 NA
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
lymph gland development inferred from mutant phenotype (Torok et al., 1993) regulation of circadian rhythm inferred from mutant phenotype (Matsumoto et al., 2007)
Cellular Component
CV term Evidence References
chromosome, centromeric region inferred from direct assay (Blower and Karpen, 2001) heterochromatin inferred from direct assay (Blower and Karpen, 2001)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
chromatin binding non-traceable author statement (Itoh, 1999.1.6, Torok, 1997.1.2)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
chromosome non-traceable author statement (Itoh, 1999.1.6)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions prod allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62853 DroID - A comprehensive database of gene and protein interactions. • FBgn0014269 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37187
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13736 Dere\GG20931 Dgri\GH19726 Dmoj\GI20147 Dper\GL10575 Dpse\GA15012 Dsec\GM19858 Dsim\prod Dvir\GJ22426 Dyak\GE13867
Curated drosophilid orthologs	Dmau\prod   Dpse\GA15012   Dsim\prod (Itoh, 1998.10.19)
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW012815 ISCW012600 FBgn0231513 FBgn0209538 FBgn0024778 FBgn0174744 FBgn0075037 FBgn0148185 FBgn0142883 FBgn0127190 FBgn0113115 FBgn0090763 ACYPI55623 ACYPI54833 ACYPI50745 ACYPI49514 ACYPI47222 ACYPI47060 ACYPI46437 ACYPI44966 ACYPI42718 ACYPI39185 ACYPI35135 ACYPI29002 ACYPI25754 ACYPI25075 ACYPI007766 ACYPI001116 AGAP001332
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	20307 y1 w67c23; P{EPgy2}prodEY11391 10814 y1 w67c23; P{lacW}prodk08810/CyO
Harvard	- PBac{PB}prodc01787
Kyoto	111248 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{neoFRT}42D P{lacW}prodk08810 /CyO y+
VDRC	v106593 P{KK104361}VIE-260B
Genomic Clones ( 1 )
	BACR08I18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 27 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD02315
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT17352 GH23414 GM02106 LD03585 LD04339 LD05152 LD05305 LD08556 LD09957 LD25585 LD27570 LD31539 LD41586 LD46391 LD47249 LP08581 RE27054 RE37425 RE46871 SD02302
Other clones	7761 81378 147937 CK01.87B.C10 EK068943 EK253415
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0014269 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37187
Antibody Information
	polyclonal (Torok et al., 1997)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: prod CG18608 (FlyBase, 1996-)
Source for database merge of	Source for merge of: prod CG18608 (Whitfield, 2000.5.15)
Additional comments	FlyBase curator comment: the insertion in the "f05153" Exelixis line (PBac{WH}CG15107f05153) was originally assigned to the prod gene in FBrf0179797, resulting in the "prodf05153" (FBal0158777) allele. However, FBrf0184340 shows that the insertion is actually within CG15107. (Bloomington Drosophila Stock Center, 2004.11.6) Source for identity of prod CG18608 was sequence comparison (date:000721). (FlyBase, 1996-)
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for prod protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) Mutants display an imaginal disc and blood cell neoplastic phenotype. (Mechler, 1994) Genetic and developmental characteristics of the lymph gland and imaginal disc overgrowth mutant have been determined. (Torok et al., 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_166317 RefSeq (Proteins) • NP_725841 DDBJ / EMBL / GenBank • AA390916 AAC32727 AAF57616 AAL13986 AB018793 AB018794 AB022040 AI531325 AQ025870 AQ073584 AW944232 AY058757 BAA76307 BAA82621 CL844456 CZ467448 U83596 Entrez Gene - A searchable database of RefSeq genes. • 37187 UniProtKB/TrEMBL • Q7JNE1 Q7KYA8 Q7KYD3
Other Crossreferences
Linkouts
	BioGRID - A database of protein and genetic interactions • 62853 DroID - A comprehensive database of gene and protein interactions. • FBgn0014269 DRSC - Results from RNAi screens. • FBgn0014269 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014269 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG18608-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0014269 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37187 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37187 modMine - Data generated by the modENCODE project. • FBgn0014269 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • ISCW012815 ISCW012600 FBgn0231513 FBgn0209538 FBgn0024778 FBgn0174744 FBgn0075037 FBgn0148185 FBgn0142883 FBgn0127190 FBgn0113115 FBgn0090763 ACYPI55623 ACYPI54833 ACYPI50745 ACYPI49514 ACYPI47222 ACYPI47060 ACYPI46437 ACYPI44966 ACYPI42718 ACYPI39185 ACYPI35135 ACYPI29002 ACYPI25754 ACYPI25075 ACYPI007766 ACYPI001116 AGAP001332
Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	CG18608 (Whitfield, 2000.5.15, Keleman et al., 2009.8.5) l(2)88/10 (Torok et al., 1997, Torok et al., 1996, Watson et al., 1994, Mechler, 1994, Gateff, 1994, Torok et al., 1993) l(2)k08810   Prod (Basto et al., 2004, Torok et al., 2000, Platero et al., 1998, Wehr et al., 2006) PROD (Csink and Henikoff, 1998, Heun et al., 2006, Moshkin et al., 2009, Filion et al., 2010) prod (Riedl et al., 2007, Torok et al., 2007, Brodsky et al., 2004, Matsumoto et al., 2007)
Name Synonym	proliferation disrupter (Ringrose and Paro, 2007)
Secondary FlyBase IDs
	FBgn0034409
References ( 60 )
Generate a list of	All references relating to this gene ( 60 )
List References by type	Research paper  ( 25 ) Supplementary material  ( 4 ) Review  ( 13 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 4 ) Computer file  ( 4 ) Letter  ( 1 )
Recent research papers ( 1 )
	Filion et al., 2010, Cell 143(2): 212--224 Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. [FBrf0212051] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...