FB2019_06, released Dec 19, 2019

Gene: Dmel\mirr

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General Information
Symbol
Dmel\mirr
Species
D. melanogaster
Name
mirror
Annotation Symbol
CG10601
Feature Type
protein_coding_gene
FlyBase ID
FBgn0014343
Gene Model Status
Current
Stock Availability
38 publicly available
Gene Snapshot
mirror (mirr) encodes an iroquois homeobox transcription factor involved in dorso-ventral axis formation during oogenesis and eye formation. It also contributes to embryonic segmentation, peripheral nervous system development and growth regulation. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
iro, Iro-C, iroquois, mrr, Sail
Key Links
Genomic Location
Cytogenetic map
69D3-69D4
Sequence location
3L:12,693,639..12,710,249 [+]
Recombination map
3-38
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
DNA-binding transcription factor activity, RNA polymerase II-specific; protein homodimerization activity
Predictions / Assertions
DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding
Summaries
Gene Group (FlyBase)
TALE HOMEOBOX TRANSCRIPTION FACTORS -
TALE homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. These proteins are characterized by an atypical homeodomain that possesses a three amino acid insertion in the first loop. (Adapted from FBrf0232555 and PMID:18797923).
Summary (Interactive Fly)
homeodomain, Pbx class - a component of the Iroquois complex - primary determiner of the border between dorsal and ventral halves of the eye - required in the dorsal mesoderm to ensure normal heart development in Drosophila.
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\mirr or the JBrowse view of Dmel\mirr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Gene model reviewed during 5.45
gene_with_stop_codon_read_through ; SO:0000697
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.44
Gene model reviewed during 5.56
Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
mirr-RA
FBtr0075911
NM_079323
3892
641
mirr-RB
FBtr0075912
NM_168505
3019
641
mirr-RC
FBtr0330077
NM_001274849
3892
682
Additional Transcript Data and Comments
Reported size (kB)
3.9 (northern blot)
(Kehl et al., 1998)
3.5 (unknown)
(McNeill et al., 1997)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
mirr-PA
FBpp0075643
67.0
641
7.19
NP_524047
AAF49894
mirr-PB
FBpp0075644
67.0
641
7.19
NP_729818
AAN11850
mirr-PC
FBpp0303110
71.2
682
7.32
NP_001261778
AGB94471
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

641 aa isoforms: mirr-PA, mirr-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
641 (aa)
(Kehl et al., 1998, McNeill et al., 1997)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mirr using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (14 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from direct assay
(Bilioni et al., 2005)
protein homodimerization activity
inferred from physical interaction with FLYBASE:mirr; FB:FBgn0014343
(Bilioni et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from sequence or structural similarity with FLYBASE:exd; FB:FBgn0000611
(McNeill et al., 1997)
sequence-specific DNA binding
inferred from electronic annotation with InterPro:IPR017970
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
compound eye morphogenesis
inferred from mutant phenotype
(Tomlinson, 2003)
dorsal appendage formation
inferred from mutant phenotype
(Peters et al., 2013, Lachance et al., 2009, Atkey et al., 2006)
embryonic development via the syncytial blastoderm
inferred from expression pattern
(McNeill et al., 1997)
inferred from mutant phenotype
(McNeill et al., 1997)
equator specification
inferred from mutant phenotype
(McNeill et al., 1997)
imaginal disc-derived wing morphogenesis
inferred from mutant phenotype
(Netter et al., 1998)
negative regulation of growth
inferred from mutant phenotype
(Barrios et al., 2015)
negative regulation of transcription by RNA polymerase II
inferred from direct assay
(Bilioni et al., 2005)
peripheral nervous system development
inferred from mutant phenotype
(Netter et al., 1998)
sensory neuron axon guidance
inferred from mutant phenotype
(Karim and Moore, 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
positive regulation of transcription, DNA-templated
inferred from sequence or structural similarity with FLYBASE:exd; FB:FBgn0000611
(McNeill et al., 1997)
inferred from sequence or structural similarity with FLYBASE:caup; FB:FBgn0015919
(McNeill et al., 1997)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
nucleus
inferred from electronic annotation with InterPro:IPR003893
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 10
organism | segmentally repeated
(McNeill et al., 1997)
neuroblast
(McNeill et al., 1997)
embryo | dorsal
(McNeill et al., 1997)
adult stage & oogenesis
follicle cell | restricted
(McNeill et al., 1997)
larval stage
imaginal disc | restricted
(McNeill et al., 1997)
eye-antennal disc | anterior | dorsal
(McNeill et al., 1997)
embryonic stage 6 -- 17
embryo | anterior | ventral
(McNeill et al., 1997)
dorsal fold
(McNeill et al., 1997)
embryonic stage 13
embryonic/larval proventriculus
(McNeill et al., 1997)
ventral nerve cord
(McNeill et al., 1997)
third instar larval stage
sensory mother cell
(Kehl et al., 1998)
oogenesis stage S9 -- S10
follicle cell | anterior | dorsal
(Zhao et al., 2000)
centripetally migrating follicle cell
(Zhao et al., 2000)
follicle cell | subset

Comment: non-mirr-expressing follicle cells

(Zhao et al., 2000)
embryonic stage 4 -- 6
foregut anlage in statu nascendi
(Fisher et al., 2012)
embryonic stage 7 -- 8
dorsal ectoderm
(Fisher et al., 2012)
foregut anlage
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
antennal primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
central brain primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
visual primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
dorsal epidermis primordium
(Fisher et al., 2012)
embryonic dorsal pouch primordium
(Fisher et al., 2012)
proventriculus primordium
(Fisher et al., 2012)
ventral epidermis primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic central brain
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
lateral cord
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
oogenesis stage S10 & adult stage | female
follicle cell | subset
(Andreu et al., 2012)
oocyte | anterior | dorsal
(Vreede et al., 2013)
follicle cell
(Peters et al., 2013)
oocyte associated follicle cell | anterior | restricted
(Nakamura et al., 2007)
oogenesis stage S13 & adult stage | female
nurse follicle cell
(Peters et al., 2013)
oogenesis stage S9 & adult stage | female
oocyte associated follicle cell | anterior | dorsal
(Nakamura et al., 2007)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
eye-antennal disc | dorsal
(Kehl et al., 1998)
presutural bristle | precursor
(Kehl et al., 1998)
postalar bristle | precursor
(Kehl et al., 1998)
wing disc | restricted
(Kehl et al., 1998)
embryonic stage -- adult stage
(Kehl et al., 1998)
Additional Descriptive Data
mirr is expressed as a single broad domain at the dorsal-anterior region of the follicle cells at stage 9. At stage 10A, mirr expression is repressed in the dorsal midline and elevated in the cells at the anterior border of this expression domain. By stage 10B, mirr is restricted to the single row of anterior cells on either side of the midline, and is almost absent by stage 11.
(Nakamura et al., 2007)
mirr transcript is expressed in a complementary pattern with that of fng transcript in follicle cells; mirr is expressed in a group of anterior dorsal follicle cells and in centripetally migrating follicle cell, while fng is expressed in the remaining follicle cells.
(Zhao et al., 2000)
fng transcript is expressed in a complementary pattern with that of mirr transcript in follicle cells; mirr is expressed in a group of anterior dorsal follicle cells and in centripetally migrating follicle cell, while fng is expressed in the remaining follicle cells.
(Zhao et al., 2000)
mirr transcript is expressed in all developmental stages. In the wing disc, mirr is expressed in regions that will give rise to the notum, the pleura, and the alula. In the eye-antennal disc, expression is restricted to the dorsal region. A Ecol\lacZ enhancer trap line (Ecol\lacZmirr-B1-12) parallels mirr transcript expression; Ecol\lacZ expression in this line is also detected in a subset of sensory organ precursor cells in the lateral heminotum, including precursors of the presutural and postalar bristles.
(Kehl et al., 1998)
mirr is expressed in an anterior and ventral patch corresponding to the presumptive anterior midgut invagination in cellular blastoderm stage embryos. Expression is also detected in the dorsal fold. At stage 10, a segmentally repeated pattern of mirr expression is detected, and colocalization with en protein places this expression in the anterior border of each segment. Shortly thereafter, delaminating neuroblasts express mirr. Expression is also seen in dorsal clusters. At germ band retraction, mirr is expressed in the ventra nerve cord, and transient expression is detected in the proventriculus. mirr is also expressed in larvae and adults, in parts of the wing, haltere, and genital imaginal discs, and the dorsal anterior follicle cells in the ovary. In eye imaginal discs, expression is detected in the dorsal anterior half of the disc.
(McNeill et al., 1997)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 10 -- 11
ectoderm | dorsal
(Mirzoyan and Pandur, 2013)
mesoderm | dorsal | restricted
(Mirzoyan and Pandur, 2013)
heart primordium | restricted
(Mirzoyan and Pandur, 2013)
Additional Descriptive Data
mirr protein is detected in the dorsal mesoderm by stage 10/11 with a more pronounced expression around the eve-positive cell clusters and in the dorsal ectoderm. The initial continuous expression
(Mirzoyan and Pandur, 2013)
along the dorsal side becomes restricted to segmental patches during stage 11 and vanishes from the dorsal mesoderm during mid-embryogenesis.
(Mirzoyan and Pandur, 2013)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{GawB}mirrDE
Stage
Tissue/Position (including subcellular localization)
Reference
wandering third instar larval stage
mesothoracic tergum primordium
(Morrison and Halder, 2010)
wing pouch
(Morrison and Halder, 2010)
dorsal mesothoracic pleura primordium
(Morrison and Halder, 2010)
wing hinge primordium
(Morrison and Halder, 2010)
haltere disc | restricted
(Morrison and Halder, 2010)
embryonic stage 11
mesoderm
(Morrison and Halder, 2010)
organism | segmentally repeated
(Morrison and Halder, 2010)
second instar larval stage -- wandering third instar larval stage
antennal disc dorsal compartment
(Morrison and Halder, 2010)
eye disc dorsal compartment
(Morrison and Halder, 2010)
third instar larval stage
eye-antennal disc | restricted
(Wang and Sun, 2012)
Reporter: P{lacW}mirr6D1
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage & oogenesis
follicle cell | dorsal
(Ruohola-Baker et al., 1993)
adult stage & oogenesis stage S10
follicle cell | anterior | dorsal
(Ruohola-Baker et al., 1993)
oogenesis stage S6 -- S8
follicle cell | restricted
(Xi et al., 2003)
Reporter: P{lacW}mirrB1-12
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
postalar bristle | precursor
(Kehl et al., 1998)
wing disc | restricted
(Kehl et al., 1998)
sensory mother cell
(Kehl et al., 1998)
presutural bristle | precursor
(Kehl et al., 1998)
eye-antennal disc | dorsal
(Kehl et al., 1998)
Reporter: P{lacW}mirrcre2
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 12
embryonic/larval oenocyte
(Hartenstein and Jan, 1998.8.10)
embryonic stage 10
epidermis
(Hartenstein and Jan, 1998.8.10)
presumptive embryonic/larval central nervous system
(Hartenstein and Jan, 1998.8.10)
embryonic stage 11
embryonic/larval digestive system
(Hartenstein and Jan, 1998.8.10)
embryonic stage 10 -- 17
embryonic brain | presumptive
(Hartenstein and Jan, 1992)
ventral nerve cord | presumptive
(Hartenstein and Jan, 1992)
epidermis & segment | dorsal
(Hartenstein and Jan, 1992)
epidermis | segmentally repeated
(Hartenstein and Jan, 1992)
embryonic stage 11 -- 17
gastric caecum | presumptive
(Hartenstein and Jan, 1992)
proventriculus | presumptive
(Hartenstein and Jan, 1992)
embryonic stage 15
ventral nerve cord | restricted
(Bier et al., 1989)
embryonic/larval foregut
(Bier et al., 1989)
embryonic/larval digestive system | restricted
(Bier et al., 1989)
Reporter: P{lacW}mirrDH-1
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
eye disc | restricted
(Sun et al., 1995)
wing disc | restricted
(Sun et al., 1995)
ventral thoracic disc | restricted
(Sun et al., 1995)
antennal disc | restricted
(Sun et al., 1995)
embryonic stage
(Sun et al., 1995)
Reporter: P{lacW}mirrDH-2
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
eye disc | restricted
(Sun et al., 1995)
wing disc | restricted
(Sun et al., 1995)
ventral thoracic disc | restricted
(Sun et al., 1995)
antennal disc | restricted
(Sun et al., 1995)
embryonic stage
(Sun et al., 1995)
Reporter: P{lacW}mirrP1
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
procephalic neurogenic region & antennal segment | dorsal | restricted
(Urbach and Technau, 2003)
embryonic stage 9 -- 11
deutocerebral neuroblast | subset
(Urbach and Technau, 2003, Zecca and Struhl, 2002)
protocerebral neuroblast | subset
(Urbach and Technau, 2003, Zecca and Struhl, 2002)
procephalic neuroblast | subset
(Urbach and Technau, 2003)
tritocerebral neuroblast | subset
(Urbach and Technau, 2003, Zecca and Struhl, 2002)
larval stage
wing disc | restricted
(Zecca and Struhl, 2002)
eye-antennal disc | dorsal
(McNeill et al., 1997)
wing cell | presumptive | subset
(Zecca and Struhl, 2002)
mesothoracic tergum primordium
(Zecca and Struhl, 2002)
embryonic stage 9 -- 10
procephalic neurogenic region | restricted
(Urbach and Technau, 2003)
embryonic stage 10
organism | segmentally repeated
(McNeill et al., 1997)
embryonic stage 14 -- 17
embryonic peripheral glial cell 6
(von Hilchen et al., 2008)
embryonic peripheral glial cell 8
(von Hilchen et al., 2008)
embryonic peripheral glial cell 10
(von Hilchen et al., 2008)
embryonic peripheral glial cell 11
(von Hilchen et al., 2008)
embryonic peripheral glial cell 12 | faint
(von Hilchen et al., 2008)
embryonic stage -- larval stage
neuroblast NB1-2
(Lacin and Truman, 2016)
neuroblast NB2-3
(Lacin and Truman, 2016)
neuroblast NB2-1
(Lacin and Truman, 2016)
neuroblast NB1-1
(Lacin and Truman, 2016)
neuroblast NB2-2
(Lacin and Truman, 2016)
neuroblast NB2-4
(Lacin and Truman, 2016)
neuroblast NB2-5
(Lacin and Truman, 2016)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mirr in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 31 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mirr
Transgenic constructs containing regulatory region of mirr
Deletions and Duplications ( 12 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal | recessive
lethal - all die before end of embryonic stage (with mirre48)
lethal - all die before end of embryonic stage (with mirrP1)
lethal - all die before end of embryonic stage | maternal effect
lethal - all die before end of embryonic stage | recessive
lethal - all die before end of larval stage | recessive
partially lethal - majority die
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority die (with mirr1825)
partially lethal - majority die (with mirre48)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
decreased occurrence of cell division | larval stage, with Scer\GAL4nub.PU
flightless, with Scer\GAL4Mef2.PR
locomotor behavior defective, with Scer\GAL4neur-GAL4-A101, mirr1825
locomotor behavior defective, with Scer\GAL4neur-GAL4-A101, mirrVDRC.cUa
locomotor behavior defective (with mirr1825), with Scer\GAL4neur-GAL4-A101
locomotor behavior defective (with mirre48), with Scer\GAL4neur-GAL4-A101
locomotor behavior defective | third instar larval stage, with Scer\GAL4neur-GAL4-A101
neuroanatomy defective, with mirr1825
neuroanatomy defective, with mirrVDRC.cUa
neuroanatomy defective, with Scer\GAL4scE1x6
neuroanatomy defective (with mirr1825)
neuroanatomy defective (with mirre48)
planar polarity defective | cell non-autonomous | somatic clone, with Scer\GAL4Ubx.PdC
planar polarity defective | recessive | somatic clone
some die during embryonic stage (with mirre48)
some die during embryonic stage (with mirrP1)
some die during embryonic stage | maternal effect
some die during embryonic stage | recessive
some die during first instar larval stage (with mirr1825)
some die during first instar larval stage (with mirre48)
some die during larval stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
visible
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4ey.PU
visible, with Scer\GAL4pnr-MD237
visible (with Df(3L)iroEGP1)
visible | dominant
visible | recessive
Phenotype manifest in
Allele
abdominal ventral multidendritic neuron vdaB, with Scer\GAL4neur-GAL4-A101, mirr1825
abdominal ventral multidendritic neuron vdaB, with Scer\GAL4neur-GAL4-A101, mirrVDRC.cUa
abdominal ventral multidendritic neuron vdaB (with mirr1825)
abdominal ventral multidendritic neuron vdaB (with mirr1825), with Scer\GAL4neur-GAL4-A101
abdominal ventral multidendritic neuron vdaB (with mirre48)
abdominal ventral multidendritic neuron vdaB (with mirre48), with Scer\GAL4neur-GAL4-A101
alula
alula | maternal effect
antennal disc
anterior postalar bristle
chorion
chorion, with Scer\GAL4C710
chorion (with mirrB1-12)
chorion (with mirrP1)
chorion | anterior | maternal effect
dendrite, with Scer\GAL4scE1x6
dendrite (with mirr1825)
dendrite (with mirre48)
denticle belt, with Scer\GAL4E4
denticle belt, with Scer\GAL4T155
dorsal appendage
dorsal appendage, with Scer\GAL48.2
dorsal appendage, with Scer\GAL4CY2
dorsal appendage, with Scer\GAL4T155
dorsal appendage, with Scer\GAL4Vm26Aa.F
dorsal appendage (with mirrB1-12)
dorsal appendage (with mirrP1)
dorsal appendage | ectopic, with Scer\GAL4T155
dorsal appendage | maternal effect
dorsal appendage | maternal effect | somatic clone
dorsal appendage | somatic clone, with Scer\GAL4Act5C.PI
dorsal margin photoreceptor | ectopic, with Scer\GAL4bi-omb-Gal4
egg, with Scer\GAL4Vm26Aa.F
egg chamber
egg operculum
embryo
embryonic/larval thoracic/abdominal ventral sensory cluster, with Scer\GAL4scE1x6
embryonic abdominal segment, with Scer\GAL4E4
eye | dorsal, with Scer\GAL4ey.PU
eye | dorsal (with Df(3L)iroEGP1)
eye | dorsal | posterior
eye | dorsal | somatic clone
eye disc, with Scer\GAL4ey.PH
eye equator | ectopic
eye equator | ectopic | somatic clone
follicle cell | somatic clone, with Scer\GAL4Act5C.PI
germarium
haltere | maternal effect
macrochaeta & adult thorax
ommatidium
ommatidium, with Scer\GAL4ey.PH
ommatidium | maternal effect
ommatidium | somatic clone
orbital bristle (with Df(3L)iroEGP1)
postalar bristle
posterior supraalar bristle
presutural bristle
scutellar bristle | maternal effect
scutum | somatic clone
tergite | cell autonomous | somatic clone, with Scer\GAL4Ubx.PdC
trichogen cell, with Scer\GAL4pnr-MD237
wing
wing, with Scer\GAL4Bx-MS1096
wing | maternal effect
wing disc | larval stage, with Scer\GAL4nub.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\IRX5
8 of 15
Yes
Yes
Hsap\IRX6
8 of 15
Yes
No
Hsap\IRX4
7 of 15
No
Yes
Hsap\IRX1
6 of 15
No
Yes
Hsap\IRX2
6 of 15
No
Yes
Hsap\IRX3
6 of 15
No
Yes
Hsap\MEIS1
1 of 15
No
No
Hsap\MEIS2
1 of 15
No
No
Hsap\MKX
1 of 15
No
No
Hsap\PKNOX1
1 of 15
No
No
 
Hsap\PKNOX2
1 of 15
No
No
 
Hsap\TGIF1
1 of 15
No
No
Hsap\TGIF2-C20orf24
1 of 15
No
No
Hsap\TGIF2
1 of 15
No
No
 
Hsap\TGIF2LX
1 of 15
No
No
 
Hsap\TGIF2LY
1 of 15
No
No
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Irx5
9 of 15
Yes
Yes
Mmus\Irx3
7 of 15
No
Yes
Mmus\Irx4
7 of 15
No
Yes
Mmus\Irx6
7 of 15
No
Yes
Mmus\Irx1
6 of 15
No
Yes
Mmus\Irx2
6 of 15
No
Yes
Mmus\Meis1
1 of 15
No
No
Mmus\Meis2
1 of 15
No
No
Mmus\Meis3
1 of 15
No
No
Mmus\Mkx
1 of 15
No
No
Mmus\Pknox1
1 of 15
No
Yes
Mmus\Pknox2
1 of 15
No
No
Mmus\Tgif1
1 of 15
No
No
Mmus\Tgif2lx1
1 of 15
No
No
Mmus\Tgif2lx2
1 of 15
No
No
Mmus\Tgif2
1 of 15
No
No
Rattus norvegicus (Norway rat) (14)
Rnor\Irx2
6 of 13
Yes
Yes
Rnor\Irx4
6 of 13
Yes
No
Rnor\Irx5
6 of 13
Yes
Yes
Rnor\Irx6
6 of 13
Yes
No
Rnor\Irx1
5 of 13
No
No
Rnor\Irx3
5 of 13
No
Yes
Rnor\Meis1
1 of 13
No
No
Rnor\Meis2
1 of 13
No
No
Rnor\Meis3
1 of 13
No
No
Rnor\Mkx
1 of 13
No
No
Rnor\Pknox1
1 of 13
No
No
Rnor\Pknox2
1 of 13
No
Yes
Rnor\Tgif1
1 of 13
No
No
Rnor\Tgif2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\irx5
7 of 12
Yes
Yes
Xtro\irx2
6 of 12
No
Yes
Xtro\irx4
6 of 12
No
Yes
Xtro\irx3
5 of 12
No
Yes
Xtro\irx1
4 of 12
No
Yes
Xtro\meis1
1 of 12
No
No
Xtro\meis2
1 of 12
No
No
Xtro\meis3
1 of 12
No
No
Xtro\mkx
1 of 12
No
No
Xtro\pknox2
1 of 12
No
Yes
Xtro\tgif1
1 of 12
No
No
Xtro\tgif2
1 of 12
No
No
Danio rerio (Zebrafish) (20)
Drer\irx4a
8 of 15
Yes
Yes
Drer\irx4b
8 of 15
Yes
Yes
Drer\irx5a
8 of 15
Yes
Yes
Drer\irx6a
8 of 15
Yes
Yes
Drer\irx2a
6 of 15
No
Yes
Drer\irx3a
6 of 15
No
No
Drer\irx1b
4 of 15
No
No
Drer\irx3b
4 of 15
No
No
Drer\irx5b
4 of 15
No
Yes
Drer\irx7
4 of 15
No
Yes
Drer\irx1a
3 of 15
No
No
Drer\meis1a
1 of 15
No
No
Drer\meis2a
1 of 15
No
No
Drer\meis2b
1 of 15
No
No
Drer\meis3
1 of 15
No
No
Drer\mkxa
1 of 15
No
No
Drer\pknox1.1
1 of 15
No
No
Drer\pknox1.2
1 of 15
No
No
Drer\pknox2
1 of 15
No
No
Drer\tgif1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (5)
Cele\irx-1
7 of 15
Yes
Yes
Cele\ceh-60
2 of 15
No
Yes
Cele\ceh-40
1 of 15
No
No
Cele\fipr-22
1 of 15
No
Yes
Cele\psa-3
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (5)
Scer\CUP9
1 of 15
Yes
No
Scer\HMLALPHA2
1 of 15
Yes
No
Scer\HMRA2
1 of 15
Yes
No
Scer\MATALPHA2
1 of 15
Yes
No
Scer\TOS8
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091906IL )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\mirr
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009819
Drosophila simulans
Dsim\GD14396
Drosophila sechellia
Dsec\GM25364
Drosophila erecta
Dere\GG15588
Drosophila yakuba
Dyak\GE21915
Drosophila ananassae
Dana\GF24692
Drosophila pseudoobscura pseudoobscura
Dpse\GA10430
Drosophila persimilis
Dper\GL25205
Drosophila willistoni
Dwil\GK25452
Drosophila virilis
Dvir\GJ11496
Drosophila mojavensis
Dmoj\GI12266
Drosophila grimshawi
Dgri\GH14720
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507UB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17014774
Glossina morsitans
Tsetse fly
Gmor\GMOY000379
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_04042
Mayetiola destructor
Hessian fly
Mdes\Mdes013615
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007502
Anopheles darlingi
American malaria mosquito
Adar\ADAC004937
Anopheles gambiae
Malaria mosquito
Agam\AGAP005011
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000127
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0MD2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA000639
Danaus plexippus
Monarch butterfly
Dple\DPOGS207179-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS207178-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL002096
Apis florea
Little honeybee
Aflo\3784344260
Apis mellifera
Western honey bee
Amel\GB55198
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16161
Bombus terrestris
Buff-tailed bumblebee
Bter\15209646
Linepithema humile
Argentine ant
Lhum\LH16531
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001eb6
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007224
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07794
Tribolium castaneum
Red flour beetle
Tcas\TC032451
Pediculus humanus
Human body louse
Phum\PHUM562470
Pediculus humanus
Human body louse
Phum\PHUM562460
Rhodnius prolixus
Kissing bug
Rpro\RPRC011579
Cimex lectularius
Bed bug
Clec\CLEC025077
Cimex lectularius
Bed bug
Clec\CLEC025077-PB
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009852
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13679
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07YI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007687
Strigamia maritima
European centipede
Smar\SMAR007692
Ixodes scapularis
Black-legged tick
Isca\ISCW012614
Ixodes scapularis
Black-legged tick
Isca\ISCW015741
Ixodes scapularis
Black-legged tick
Isca\ISCW015737
Ixodes scapularis
Black-legged tick
Isca\ISCW015739
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67476.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58187.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM64210.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM79065.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g03270
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g03220
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_28797
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_28488
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_104948
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0N9R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-IrxA
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000018956
Ciona intestinalis
Vase tunicate
Cint\irx-b
Ciona intestinalis
Vase tunicate
Cint\irx-c
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000022896
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000023738
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
ara
6 of 10
caup
6 of 10
CG11617
3 of 10
achi
1 of 10
hth
1 of 10
vis
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    mirrDFM3
    exacerbates  cancer
    modeled by DlUAS.cDa, lolaGS88A8, psqGS88A8
    (Barrios et al., 2015)
    mirrGD16318
    exacerbates  cancer
    modeled by DlUAS.cDa, lolaGS88A8, psqGS88A8
    (Barrios et al., 2015)
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    IRX5; iroquois homeobox 5
    8 of 15
    606195
      IRX6; iroquois homeobox 6
      8 of 15
      606196
          IRX4; iroquois homeobox 4
          7 of 15
          606199
              IRX1; iroquois homeobox 1
              6 of 15
              606197
                  IRX2; iroquois homeobox 2
                  6 of 15
                  606198
                      IRX3; iroquois homeobox 3
                      6 of 15
                      612985
                          Functional Complementation Data
                          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                          Interactions
                          Summary of Physical Interactions
                          esyN Network Diagram
                          Show neighbor-neighbor interactions:
                          Select Layout:
                          Legend:
                          Protein
                          RNA
                          Selected Interactor(s)
                          Interactions Browser
                          View in Interactions Browser
                          Please see the Physical Interaction reports below for full details
                          protein-protein
                          Physical Interaction
                          Assay
                          References
                          mirr - CG1407
                          two hybrid array
                          (Shokri et al., 2019)
                          mirr - CG31441
                          two hybrid array
                          (Shokri et al., 2019)
                          mirr - Dll
                          two hybrid array
                          (Shokri et al., 2019)
                          mirr - Su(H)
                          two hybrid array
                          (Shokri et al., 2019)
                          mirr - Unr
                          two hybrid array
                          (Shokri et al., 2019)
                          mirr - opa
                          two hybrid array
                          (Shokri et al., 2019)
                          mirr - zld
                          two hybrid array
                          (Shokri et al., 2019)
                          Summary of Genetic Interactions
                          esyN Network Diagram
                          esyN Network Key:
                          Suppression
                          Enhancement
                          View in Interactions Browser
                          Please look at the allele data for full details of the genetic interactions
                          Starting gene(s)
                          Interaction type
                          Interacting gene(s)
                          Reference
                          mirr
                          suppressible
                          CycE
                          (Barrios et al., 2015)
                          mirr
                          suppressible
                          fng
                          (Yang et al., 1999)
                          mirr
                          enhanceable
                          Mob
                          (Kehl et al., 1998)
                          mirr
                          suppressible
                          Pax
                          (Peters et al., 2013)
                          mirr
                          enhanceable
                          ttk
                          (Peters et al., 2013)
                          Starting gene(s)
                          Interaction type
                          Interacting gene(s)
                          Reference
                          caz
                          suppressible
                          mirr
                          (Shimamura et al., 2014)
                          cic
                          suppressible
                          mirr
                          (Atkey et al., 2006)
                          Dl
                          enhanceable
                          mirr
                          (Barrios et al., 2015)
                          hng1
                          enhanceable
                          mirr
                          (Shukla et al., 2014)
                          L
                          enhanceable
                          mirr
                          (Singh et al., 2005)
                          lola|psq|Dl
                          enhanceable
                          mirr
                          (Barrios et al., 2015)
                          smo
                          enhanceable
                          mirr
                          (Collins, 2005.7.7, Collins and Cohen, 2005)
                          External Data
                          Linkouts
                          BioGRID - A database of protein and genetic interactions.
                          DroID - A comprehensive database of gene and protein interactions.
                          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                          MIST (genetic) - An integrated Molecular Interaction Database
                          Pathways
                          Signaling Pathways (FlyBase)
                          Metabolic Pathways
                          External Data
                          Linkouts
                          Genomic Location and Detailed Mapping Data
                          Chromosome (arm)
                          3L
                          Recombination map
                          3-38
                          Cytogenetic map
                          69D3-69D4
                          Sequence location
                          3L:12,693,639..12,710,249 [+]
                          FlyBase Computed Cytological Location
                          Cytogenetic map
                          Evidence for location
                          69D3-69D4
                          Limits computationally determined from genome sequence between P{PZ}l(3)0508805088 and P{PZ}l(3)0692406924
                          Experimentally Determined Cytological Location
                          Cytogenetic map
                          Notes
                          References
                          69D-69D
                          (Kehl, 1997.5.19, McNeill, 1997.3.24, Gomez-Skarmeta et al., 1996)
                          69D-69D
                          (determined by in situ hybridisation)
                          (McNeill et al., 1997, Choi et al., 1996, Hartenstein and Jan, 1992)
                          69D1-69D3
                          (determined by in situ hybridisation)
                          (Coen et al., 1997)
                          69C8-69C11
                          (determined by in situ hybridisation)
                          (Sun et al., 1995)
                          Map location determined by in situ hybrisation to an unspecified insertion allele of mirr.
                          (Coen et al., 1997)
                          Experimentally Determined Recombination Data
                          Location
                          3-38
                          (FlyBase, 2016)
                          3-33.1
                          (Comeron et al., 2012)
                          3-
                          (Collins and Cohen, 2005, Coen et al., 1997, Gomez-Skarmeta et al., 1996)
                          3-37.9
                          (Carpenter, 1999, Kehl et al., 1998, Carpenter, 1994)
                          Left of (cM)
                          (Collins and Cohen, 2005)
                          Right of (cM)
                          (Collins and Cohen, 2005)
                          (Netter et al., 1998)
                          Notes
                          Can be 1.5% recombination between ara and mirr, with none between ara and caup.
                          (Netter et al., 1998)
                          Mapped using mirrSai2.
                          (Carpenter, 1994)
                          Stocks and Reagents
                          Stocks (38)
                          Genomic Clones (18)
                           

                          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                          cDNA Clones (53)
                           

                          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                          cDNA clones, fully sequences
                          BDGP DGC clones
                            Other clones
                            Drosophila Genomics Resource Center cDNA clones

                            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                            cDNA Clones, End Sequenced (ESTs)
                            BDGP DGC clones
                            Other clones
                            RNAi and Array Information
                            Linkouts
                            DRSC - Results frm RNAi screens
                            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                            Antibody Information
                            Laboratory Generated Antibodies
                             
                            Commercially Available Antibodies
                             
                            Other Information
                            Relationship to Other Genes
                            Source for database identify of
                            Source for identity of: mirr CG10601
                            (Bayraktaroglu, 1999.11)
                            Source for database merge of
                            Source for merge of: mirr Sai crep
                            (Coen, 1997.8.14)
                            Additional comments
                            Other Comments
                            mirr is required for the proper routing of class IV topographic axonal projections across the midline of the CNS.
                            (Karim and Moore, 2011)
                            mirr expression at SOP stages converts other lineages to produce neurons with class IV character.
                            (Karim and Moore, 2011)
                            mirr is required cell-autonomously for induction of all dorsal anterior follicle cell fates.
                            (Lachance et al., 2009)
                            Iroquois complex genes (ara, caup and mirr) are required for the specification of dorsal head structures.
                            (Cavodeassi et al., 2000)
                            The localised expression of the three genes of the iroquois complex - IRO-C (ara, caup and mirr) specifies the identity of dorsal cells in the eye. Juxtaposition of IRO-C-expressing and non-expressing cells forms a straight border that promotes growth and serves as a pattern-organising centre in the eye disc.
                            (Cavodeassi et al., 1999)
                            When the Iroquois complex is absent, notum cells are transformed into hinge (tegula and sclerite) cells.
                            (Diez del Corral et al., 1999)
                            The genes of the Iroquois complex (ara, caup and mirr) are necessary for notum specification. The Iro-C genes establish a signalling system that appears to organize development in the notum and dorsal wing hinge (tegula and sclerite) territories.
                            (Diez del Corral et al., 1999)
                            mirr defines the location of the equator in the eye by creating a boundary of fng expression at the mid-point of the eye (by repressing fng expression in the dorsal half of the eye). mirr acts to sharpen the equator by reducing the mixing of dorsal and ventral cells at the equator.
                            (Yang et al., 1999)
                            Based on genetic map position, expression, protein structure and function, mirr is considered a new member of the iroquois complex.
                            (Kehl et al., 1998)
                            mirr is required for the formation of the alula, a subset of sensory bristles in the lateral domain of the notum and wing positioning. Genetic analysis suggest that mirr and other iroquois genes interact to form the alula as well as the sensory organs.
                            (Kehl et al., 1998)
                            The phenotype of mirr mutations implicates it in wing and peripheral nervous system development. The genes of the IRO-C are coordinately regulated and implicated in similar developmental processes. They are regulated in the eye by the Pc-group and trx-group genes, but not by classical modifiers of position effect variegation. Ventral silencing of the whole IRO-C in the eye occurs at the level of chromatin structure in a manner similar to that of the homeotic gene complexes, perhaps by local compaction of the region into a heterochromatin-like structure involving Pc-group products.
                            (Netter et al., 1998)
                            Defined by a lethal P-element enhancer trap insertion, Ecol\lacZ expression is dorsally limited in the third instar eye imaginal disc.
                            (Coen et al., 1997)
                            mirr plays an important role in defining the equator; the juxtaposition of mirr expressing and nonexpressing cells defines the equator. Analysis of mirr expression pattern and loss of function phenotype suggests mirr also acts in the definition of the segmental border.
                            (McNeill et al., 1997)
                            Identification: Identified on basis of lethality caused by a P{lacW} insertion.
                            (Choi et al., 1996)
                            mirr may participate in sensory organ formation in the lateral notum, may be able to substitute for ara and caup function and may represent another member of the Iroquois complex.
                            (Gomez-Skarmeta et al., 1996)
                            Defined by an insertion of P{lacW}.
                            (Sun et al., 1995)
                            Identification: Lethal enhancer trap insertion.
                            (Ruohola-Baker et al., 1993)
                            Origin and Etymology
                            Discoverer
                            Etymology
                            'crepuscule' means 'twilight' in French. A member of the IRO-C (Iroquois complex).
                            (Netter et al., 1998)
                            Identification
                            External Crossreferences and Linkouts ( 45 )
                            Sequence Crossreferences
                            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                            Other crossreferences
                            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                            Flygut - An atlas of the Drosophila adult midgut
                            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                            InterPro - A database of protein families, domains and functional sites
                            KEGG Genes - Molecular building blocks of life in the genomic space.
                            modMine - A data warehouse for the modENCODE project
                            Linkouts
                            ApoDroso - Functional genomic database for photoreceptor development, survival and function
                            BioGRID - A database of protein and genetic interactions.
                            DroID - A comprehensive database of gene and protein interactions.
                            DRSC - Results frm RNAi screens
                            FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                            FlyMine - An integrated database for Drosophila genomics
                            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                            MIST (genetic) - An integrated Molecular Interaction Database
                            Synonyms and Secondary IDs (33)
                            Reported As
                            Symbol Synonym
                            CG10601
                            (Ibrahim et al., 2013, Perkins et al., 2009, Molnar et al., 2006)
                            DH1
                            (Bishop et al., 1999)
                            De1
                            (Coen et al., 1997)
                            De3
                            (Coen et al., 1997)
                            Group F
                            (Collins and Cohen, 2005)
                            IRO-C
                            (Villa-Cuesta and Modolell, 2004, Wernet and Desplan, 2004, Cavodeassi et al., 1999)
                            Iro
                            (Callejo et al., 2006, Tomlinson, 2003)
                            Iro-C
                            (Curtis et al., 2013, Cruz et al., 2009, Villa-Cuesta et al., 2007, Villa-Cuesta and Modolell, 2005, Singh and Choi, 2004, Baena-Lopez et al., 2003, D'Costa and Moses, 2003, Arnosti, 2002, Cavodeassi et al., 2002)
                            IroC
                            (Thanawala et al., 2013)
                            MIRR
                            (Pyrowolakis et al., 2017, Jepson et al., 2013)
                            Mirr
                            (Barrios and Campuzano, 2015, Villa-Cuesta et al., 2007, Buescher et al., 2006)
                            Mrr
                            (Modolell and Campuzano, 1998)
                            Sai
                            (Carpenter, 1994)
                            cre
                            (Coen et al., 1997)
                            crep
                            group F
                            (Collins, 2005.7.7)
                            iro
                            (Bovolenta et al., 2006, Sato et al., 2006, Simpson et al., 2006, Wendler et al., 2006, Torroja et al., 2005, Crozatier et al., 2004, Ogden et al., 2004, de Celis, 2003, Ghysen and Thomas, 2003)
                            iro-C
                            (Rudel and Sommer, 2003, Calleja et al., 2002, Skaer et al., 2002)
                            l(3)69Ca
                            l(3)69Da
                            l(3)6D1
                            (Morimoto et al., 1996, Ruohola-Baker et al., 1993)
                            l(3)A5-3-42
                            (Hartenstein and Jan, 1992)
                            mir
                            (Broadus et al., 1995)
                            mirr
                            (Balaji et al., 2019, Seong et al., 2019, Shokri et al., 2019, Bischof et al., 2018, Valsecchi et al., 2018, Forés et al., 2017, Li et al., 2017, Osterfield et al., 2017, Reichert, 2017, Revaitis et al., 2017, Transgenic RNAi Project members, 2017-, Bürglin and Affolter, 2016, Sarov et al., 2016, Wang et al., 2016, Barrios et al., 2015, Charbonnier et al., 2015, Lee et al., 2015, Legent et al., 2015, Schertel et al., 2015, Spratford and Kumar, 2015, Tsai et al., 2015, Fauré et al., 2014, Shimamura et al., 2014, Curtis et al., 2013, Fregoso Lomas et al., 2013, Ibrahim et al., 2013, McKay and Lieb, 2013, Peters et al., 2013, Tian et al., 2013, Andreu et al., 2012, Del Signore et al., 2012, Fuchs et al., 2012, Jungreis et al., 2011, Karim and Moore, 2011, King et al., 2011, Ozdemir et al., 2011, Singh et al., 2011, Sun et al., 2011, Fernández-Ayala et al., 2010, Irimia et al., 2010, Pospisilik et al., 2010, Roignant et al., 2010, Schwartz et al., 2010, Fang et al., 2009, Flaherty et al., 2009, Foronda et al., 2009, Grieder et al., 2009, Gutierrez-Aviño et al., 2009, Kerner et al., 2009, Lachance et al., 2009, Ohayon et al., 2009, Tian et al., 2009, Beckervordersandforth et al., 2008, Mazzoni et al., 2008, Yakoby et al., 2008, Astigarraga et al., 2007, Beltran et al., 2007, Buszczak et al., 2007, IKMI and COEN, 2007, Kankel et al., 2007, Maines et al., 2007, Minidorff et al., 2007, Minidorff et al., 2007, Mukherjee and Bürglin, 2007, Nakamura et al., 2007, Sato and Tomlinson, 2007, Hashimoto and Yamaguchi, 2006, Miura et al., 2006, Molnar et al., 2006, Sato et al., 2006, Althauser et al., 2005, Bilioni et al., 2005, Jordan et al., 2005, Roederer et al., 2005)
                            mrr
                            (Berger et al., 2008, Calleja et al., 2000, Heberlein et al., 1998, McNeill, 1997.3.24, McNeill et al., 1997)
                            Name Synonyms
                            Iroquis complex
                            (Brennan and Gardner, 2002)
                            Iroquois
                            (Bilioni et al., 2004)
                            Mirror
                            (Fregoso Lomas et al., 2013, Jepson et al., 2013, Fuchs et al., 2012, Villa-Cuesta et al., 2007, Buescher et al., 2006, Fanto and McNeill, 2004)
                            Sail
                            (Russell, 1999.1.25, Kehl, 1997.5.19, Carpenter, 1994)
                            caupalican
                            (Tepass et al., 2002)
                            crepuscule
                            (Coen et al., 1997)
                            iroquois
                            (Hernández de Madrid and Casanova, 2018, Bovolenta et al., 2006, Simpson et al., 2006, Wendler et al., 2006, Sato et al., 2005, Torroja et al., 2005, Skaer et al., 2002, Nepveu, 2001)
                            mirror
                            (Ariss et al., 2018, Osterfield et al., 2017, Wang et al., 2016, Álvarez-Fernández et al., 2015, Forés et al., 2015, Shimamura et al., 2014, Shukla et al., 2014, Ibrahim et al., 2013, Peters et al., 2013, Tian et al., 2013, Zimmerman et al., 2013, Carrasco-Rando et al., 2011, King et al., 2011, Ozdemir et al., 2011, Tolhuis et al., 2011, Irimia et al., 2010, Morrison and Halder, 2010, Roignant et al., 2010, Flaherty et al., 2009, Foronda et al., 2009, Grieder et al., 2009, Gutierrez-Aviño et al., 2009, Kerner et al., 2009, Ohayon et al., 2009, Southall and Brand, 2009, Beckervordersandforth et al., 2008, Berger et al., 2008, Grau et al., 2008, Astigarraga et al., 2007, González-Pérez et al., 2007, Hashimoto and Yamaguchi, 2007, IKMI and COEN, 2007, Kankel et al., 2007, Atkey et al., 2006, Hashimoto and Yamaguchi, 2006, Sato et al., 2006, Althauser et al., 2005, Jordan et al., 2005, Roederer et al., 2005, McNeill et al., 1995)
                            Secondary FlyBase IDs
                            • FBgn0013332
                            • FBgn0013561
                            • FBgn0013593
                            • FBgn0016017
                            • FBgn0017368
                            • FBgn0020310
                            Datasets (0)
                            Study focus (0)
                            Experimental Role
                            Project
                            Project Type
                            Title
                            References (276)