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General Information
Symbol
Dmel\mirr
Species
D. melanogaster
Name
mirror
Annotation Symbol
CG10601
Feature Type
FlyBase ID
FBgn0014343
Gene Model Status
Stock Availability
Gene Snapshot
mirror (mirr) encodes an iroquois homeobox transcription factor involved in dorso-ventral axis formation during oogenesis and eye formation. It also contributes to embryonic segmentation, peripheral nervous system development and growth regulation. [Date last reviewed: 2019-03-14]
Also Known As

Iro-C, iro, iroquois, mrr, Sail

Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:12,693,639..12,710,249 [+]
Recombination map

3-38

RefSeq locus
NT_037436 REGION:12693639..12710249
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
TALE HOMEOBOX TRANSCRIPTION FACTORS -
TALE homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. These proteins are characterized by an atypical homeodomain that possesses a three amino acid insertion in the first loop. (Adapted from FBrf0232555 and PMID:18797923).
Summary (Interactive Fly)

homeodomain, Pbx class - a component of the Iroquois complex - primary determiner of the border between dorsal and ventral halves of the eye - required in the dorsal mesoderm to ensure normal heart development in Drosophila.

Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\mirr or the JBrowse view of Dmel\mirr for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.55

Gene model reviewed during 5.45

gene_with_stop_codon_read_through ; SO:0000697

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.44

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0075911
3892
641
FBtr0075912
3019
641
FBtr0330077
3892
682
Additional Transcript Data and Comments
Reported size (kB)

3.9 (northern blot)

3.5 (unknown)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0075643
67.0
641
7.19
FBpp0075644
67.0
641
7.19
FBpp0303110
71.2
682
7.32
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

641 aa isoforms: mirr-PA, mirr-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\mirr using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (14 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
Biological Process (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from sequence or structural similarity with FLYBASE:exd; FB:FBgn0000611
inferred from sequence or structural similarity with FLYBASE:caup; FB:FBgn0015919
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR003893
(assigned by InterPro )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
antennal primordium

Comment: reported as procephalic ectoderm primordium

central brain primordium

Comment: reported as procephalic ectoderm primordium

visual primordium

Comment: reported as procephalic ectoderm primordium

dorsal head epidermis primordium

Comment: reported as procephalic ectoderm primordium

lateral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

ventral head epidermis primordium

Comment: reported as procephalic ectoderm primordium

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

mirr is expressed as a single broad domain at the dorsal-anterior region of the follicle cells at stage 9. At stage 10A, mirr expression is repressed in the dorsal midline and elevated in the cells at the anterior border of this expression domain. By stage 10B, mirr is restricted to the single row of anterior cells on either side of the midline, and is almost absent by stage 11.

mirr transcript is expressed in a complementary pattern with that of fng transcript in follicle cells; mirr is expressed in a group of anterior dorsal follicle cells and in centripetally migrating follicle cell, while fng is expressed in the remaining follicle cells.

fng transcript is expressed in a complementary pattern with that of mirr transcript in follicle cells; mirr is expressed in a group of anterior dorsal follicle cells and in centripetally migrating follicle cell, while fng is expressed in the remaining follicle cells.

mirr transcript is expressed in all developmental stages. In the wing disc, mirr is expressed in regions that will give rise to the notum, the pleura, and the alula. In the eye-antennal disc, expression is restricted to the dorsal region. A Ecol\lacZ enhancer trap line (Ecol\lacZmirr-B1-12) parallels mirr transcript expression; Ecol\lacZ expression in this line is also detected in a subset of sensory organ precursor cells in the lateral heminotum, including precursors of the presutural and postalar bristles.

mirr is expressed in an anterior and ventral patch corresponding to the presumptive anterior midgut invagination in cellular blastoderm stage embryos. Expression is also detected in the dorsal fold. At stage 10, a segmentally repeated pattern of mirr expression is detected, and colocalization with en protein places this expression in the anterior border of each segment. Shortly thereafter, delaminating neuroblasts express mirr. Expression is also seen in dorsal clusters. At germ band retraction, mirr is expressed in the ventra nerve cord, and transient expression is detected in the proventriculus. mirr is also expressed in larvae and adults, in parts of the wing, haltere, and genital imaginal discs, and the dorsal anterior follicle cells in the ovary. In eye imaginal discs, expression is detected in the dorsal anterior half of the disc.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

mirr protein is detected in the dorsal mesoderm by stage 10/11 with a more pronounced expression around the eve-positive cell clusters and in the dorsal ectoderm. The initial continuous expression

along the dorsal side becomes restricted to segmental patches during stage 11 and vanishes from the dorsal mesoderm during mid-embryogenesis.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{GawB}mirrDE
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}mirr6D1
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}mirrB1-12
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}mirrcre2
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}mirrDH-1
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}mirrDH-2
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{lacW}mirrP1
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\mirr in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 31 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of mirr
Transgenic constructs containing regulatory region of mirr
Deletions and Duplications ( 12 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
macrochaeta & adult thorax
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (15)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
9 of 15
Yes
No
8 of 15
No
No
5 of 15
No
Yes
5 of 15
No
Yes
5 of 15
No
Yes
3 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
8 of 15
Yes
No
8 of 15
Yes
No
6 of 15
No
Yes
5 of 15
No
Yes
5 of 15
No
Yes
4 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (14)
7 of 13
Yes
No
7 of 13
Yes
No
4 of 13
No
No
4 of 13
No
Yes
4 of 13
No
Yes
3 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (12)
8 of 12
Yes
Yes
5 of 12
No
No
5 of 12
No
Yes
4 of 12
No
No
4 of 12
No
Yes
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (21)
9 of 15
Yes
Yes
8 of 15
No
Yes
8 of 15
No
Yes
6 of 15
No
No
5 of 15
No
Yes
5 of 15
No
Yes
4 of 15
No
No
4 of 15
No
No
3 of 15
No
No
3 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
5 of 15
Yes
No
1 of 15
No
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (5)
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091906IL )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507UB )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0MD2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07YI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0N9R )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (6)
7 of 10
6 of 10
3 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 2 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map

    3-38

    Cytogenetic map
    Sequence location
    3L:12,693,639..12,710,249 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    69D3-69D4
    Limits computationally determined from genome sequence between P{PZ}l(3)0508805088 and P{PZ}l(3)0692406924
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    69D-69D
    (determined by in situ hybridisation)
    69D1-69D3
    (determined by in situ hybridisation)
    69C8-69C11
    (determined by in situ hybridisation)
    Map location determined by in situ hybrisation to an unspecified insertion allele of mirr.
    Experimentally Determined Recombination Data
    Notes

    Can be 1.5% recombination between ara and mirr, with none between ara and caup.

    Mapped using mirrSai2.

    Stocks and Reagents
    Stocks (38)
    Genomic Clones (18)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (53)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: mirr CG10601

      Source for database merge of

      Source for merge of: mirr Sai crep

      Additional comments
      Other Comments

      mirr is required for the proper routing of class IV topographic axonal projections across the midline of the CNS.

      mirr expression at SOP stages converts other lineages to produce neurons with class IV character.

      mirr is required cell-autonomously for induction of all dorsal anterior follicle cell fates.

      Iroquois complex genes (ara, caup and mirr) are required for the specification of dorsal head structures.

      The localised expression of the three genes of the iroquois complex - IRO-C (ara, caup and mirr) specifies the identity of dorsal cells in the eye. Juxtaposition of IRO-C-expressing and non-expressing cells forms a straight border that promotes growth and serves as a pattern-organising centre in the eye disc.

      When the Iroquois complex is absent, notum cells are transformed into hinge (tegula and sclerite) cells.

      The genes of the Iroquois complex (ara, caup and mirr) are necessary for notum specification. The Iro-C genes establish a signalling system that appears to organize development in the notum and dorsal wing hinge (tegula and sclerite) territories.

      mirr defines the location of the equator in the eye by creating a boundary of fng expression at the mid-point of the eye (by repressing fng expression in the dorsal half of the eye). mirr acts to sharpen the equator by reducing the mixing of dorsal and ventral cells at the equator.

      Based on genetic map position, expression, protein structure and function, mirr is considered a new member of the iroquois complex.

      mirr is required for the formation of the alula, a subset of sensory bristles in the lateral domain of the notum and wing positioning. Genetic analysis suggest that mirr and other iroquois genes interact to form the alula as well as the sensory organs.

      The phenotype of mirr mutations implicates it in wing and peripheral nervous system development. The genes of the IRO-C are coordinately regulated and implicated in similar developmental processes. They are regulated in the eye by the Pc-group and trx-group genes, but not by classical modifiers of position effect variegation. Ventral silencing of the whole IRO-C in the eye occurs at the level of chromatin structure in a manner similar to that of the homeotic gene complexes, perhaps by local compaction of the region into a heterochromatin-like structure involving Pc-group products.

      Defined by a lethal P-element enhancer trap insertion, Ecol\lacZ expression is dorsally limited in the third instar eye imaginal disc.

      mirr plays an important role in defining the equator; the juxtaposition of mirr expressing and nonexpressing cells defines the equator. Analysis of mirr expression pattern and loss of function phenotype suggests mirr also acts in the definition of the segmental border.

      Identification: Identified on basis of lethality caused by a P{lacW} insertion.

      mirr may participate in sensory organ formation in the lateral notum, may be able to substitute for ara and caup function and may represent another member of the Iroquois complex.

      Defined by an insertion of P{lacW}.

      Identification: Lethal enhancer trap insertion.

      Origin and Etymology
      Discoverer
      Etymology

      'crepuscule' means 'twilight' in French. A member of the IRO-C (Iroquois complex).

      Identification
      External Crossreferences and Linkouts ( 45 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      ApoDroso - Functional genomic database for photoreceptor development, survival and function
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (33)
      Reported As
      Symbol Synonym
      crep
      l(3)69Ca
      l(3)69Da
      mirr
      (Balaji et al., 2019, Seong et al., 2019, Shokri et al., 2019, Bischof et al., 2018, Valsecchi et al., 2018, Forés et al., 2017, Karaiskos et al., 2017, Li et al., 2017, Osterfield et al., 2017, Reichert, 2017, Revaitis et al., 2017, Transgenic RNAi Project members, 2017-, Bürglin and Affolter, 2016, Sarov et al., 2016, Wang et al., 2016, Barrios et al., 2015, Charbonnier et al., 2015, Lee et al., 2015, Legent et al., 2015, Schertel et al., 2015, Spratford and Kumar, 2015, Tsai et al., 2015, Fauré et al., 2014, Shimamura et al., 2014, Curtis et al., 2013, Fregoso Lomas et al., 2013, Ibrahim et al., 2013, McKay and Lieb, 2013, Peters et al., 2013, Tian et al., 2013, Andreu et al., 2012, Del Signore et al., 2012, Fuchs et al., 2012, Jungreis et al., 2011, Karim and Moore, 2011, King et al., 2011, Ozdemir et al., 2011, Singh et al., 2011, Sun et al., 2011, Fernández-Ayala et al., 2010, Irimia et al., 2010, Pospisilik et al., 2010, Roignant et al., 2010, Schwartz et al., 2010, Fang et al., 2009, Flaherty et al., 2009, Foronda et al., 2009, Grieder et al., 2009, Gutierrez-Aviño et al., 2009, Kerner et al., 2009, Lachance et al., 2009, Ohayon et al., 2009, Tian et al., 2009, Beckervordersandforth et al., 2008, Mazzoni et al., 2008, Yakoby et al., 2008, Astigarraga et al., 2007, Beltran et al., 2007, Buszczak et al., 2007, IKMI and COEN, 2007, Kankel et al., 2007, Maines et al., 2007, Minidorff et al., 2007, Minidorff et al., 2007, Mukherjee and Bürglin, 2007, Nakamura et al., 2007, Sato and Tomlinson, 2007, Hashimoto and Yamaguchi, 2006, Miura et al., 2006, Molnar et al., 2006, Sato et al., 2006, Althauser et al., 2005, Bilioni et al., 2005, Jordan et al., 2005, Roederer et al., 2005)
      Secondary FlyBase IDs
      • FBgn0013332
      • FBgn0013561
      • FBgn0013593
      • FBgn0016017
      • FBgn0017368
      • FBgn0020310
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      References (278)