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Gene Dmel\noi

General Information
Symbol	Dmel\noi	Species	D. melanogaster
Name	noisette	Annotation symbol	CG2925
Feature type	protein_coding_gene	FlyBase ID	FBgn0014366
Gene Model Status	Current	Stock availability	9 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	83B4-83B4	Sequence location	3R:1,415,323..1,417,181 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene noisette is referred to in FlyBase by the symbol Dmel\noi (CG2925, FBgn0014366). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; nucleic acid binding. There is experimental evidence that it is involved in the biological process: fertilization; mitosis; positive regulation of NFAT protein import into nucleus; mitotic spindle organization. 17 alleles are reported. The phenotypes of these alleles are annotated with: egg; medial triple row; sex comb; oocyte nucleus; dorsal appendage; nurse cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Domain of unknown function DUF3449; Splicing factor SF3a60 binding domain; Zinc finger, C2H2-like; Zinc finger, C2H2-type matrin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1630805_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of noi. Gene sequence location is 3R:1415323..1417181.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Controlled Vocabulary Terms regulation of cell cycle
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 83B4-83B4   Limits computationally determined from genome sequence between P{PZ}Snr101319&P{PZ}Itp-r83A05616 and P{lacW}Atus1938
Experimentally Determined Cytological Location
Cytogenetic map Notes References 83B1-83B2   (determined by in situ hybridisation)   (Spradling et al., 1999) 83B-83B   (determined by in situ hybridisation)   (Meyer et al., 1998) 83B1-83B2   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\noi for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) noi-RA FBtr0078751  NM_057766   1859   503
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein noi-PA   FBpp0078400   58.4   503   5.34     NP_477114   AAF51999
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-type matrin (IPR000690) Zinc finger, C2H2-like (IPR015880) Domain of unknown function DUF3449 (IPR024598) Splicing factor SF3a60 binding domain (IPR021966)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202049   AA441548   AA541182   AA802600   AA820123   AA942120   AE014297 AAF51999   AC009538   AI295618   AI455297   AI516431   AI518561   AJ223042 CAA11045   AQ026316   AY051676 AAK93100   BI165509   BI167802   BI227743   BI230811   BI354799   BI358252   BI568442   BI621100   BI632986   BI635408   BI639957   BP553356   BP553357   CO177457   CO178324   CO276144   CO286598   CO299551   CO329414   CO329783   CO342877   CZ487902   CZ488017   CZ488018   EC080902   EC081140   EC198584   EC200284   EC204880   EC252354
UniProtKB/Swiss-Prot	O46106
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | faint & ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    509 Larval Midgut    133.5 Larval Hindgut    202.4 Larval Malpighian Tubules    160.2 Larval Fat Body    150.1 Larval Salivary Gland    327.4 Larval Trachea    291.975 Larval Carcass    219.7 Adult Head    143.5 Adult Eye    150.95 Adult Brain    231.2 Adult Thoracic-Abdominal Ganglion    165.4 Adult Crop    184.9 Adult Midgut    168.3 Adult Hindgut    161.4 Adult Malpighian Tubules    161.1 Adult Fat Body    140.8 Adult Salivary Gland    148.2 Adult Heart    114.3 Adult VirginFemale Spermatheca    221.8 Adult InseminatedFemale Spermatheca    237.5 Adult Ovary    440.5 Adult Testis    171.6 Adult Male Accessory Gland    296.8 Adult Carcass    94.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  509 Larval Midgut    133.5 Larval Hindgut    202.4 Larval Malpighian Tubules    160.2 Larval Fat Body    150.1 Larval Salivary Gland    327.4 Larval Trachea    291.975 Larval Carcass    219.7 Adult Head    143.5 Adult Eye    150.95 Adult Brain    231.2 Adult Thoracic-Abdominal Ganglion    165.4 Adult Crop    184.9 Adult Midgut    168.3 Adult Hindgut    161.4 Adult Malpighian Tubules    161.1 Adult Fat Body    140.8 Adult Salivary Gland    148.2 Adult Heart    114.3 Adult VirginFemale Spermatheca    221.8 Adult InseminatedFemale Spermatheca    237.5 Adult Ovary    440.5 Adult Testis    171.6 Adult Male Accessory Gland    296.8 Adult Carcass    94.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    509 Larval Midgut    133.5 Larval Hindgut    202.4 Larval Malpighian Tubules    160.2 Larval Fat Body    150.1 Larval Salivary Gland    327.4 Larval Trachea    291.975 Larval Carcass    219.7 Adult Head    143.5 Adult Eye    150.95 Adult Brain    231.2 Adult Thoracic-Abdominal Ganglion    165.4 Adult Crop    184.9 Adult Midgut    168.3 Adult Hindgut    161.4 Adult Malpighian Tubules    161.1 Adult Fat Body    140.8 Adult Salivary Gland    148.2 Adult Heart    114.3 Adult VirginFemale Spermatheca    221.8 Adult InseminatedFemale Spermatheca    237.5 Adult Ovary    440.5 Adult Testis    171.6 Adult Male Accessory Gland    296.8 Adult Carcass    94.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    509 Larval Midgut    133.5 Larval Hindgut    202.4 Larval Malpighian Tubules    160.2 Larval Fat Body    150.1 Larval Salivary Gland    327.4 Larval Trachea    291.975 Larval Carcass    219.7 Adult Head    143.5 Adult Eye    150.95 Adult Brain    231.2 Adult Thoracic-Abdominal Ganglion    165.4 Adult Crop    184.9 Adult Midgut    168.3 Adult Hindgut    161.4 Adult Malpighian Tubules    161.1 Adult Fat Body    140.8 Adult Salivary Gland    148.2 Adult Heart    114.3 Adult VirginFemale Spermatheca    221.8 Adult InseminatedFemale Spermatheca    237.5 Adult Ovary    440.5 Adult Testis    171.6 Adult Male Accessory Gland    296.8 Adult Carcass    94.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    509 Larval Midgut    133.5 Larval Hindgut    202.4 Larval Malpighian Tubules    160.2 Larval Fat Body    150.1 Larval Salivary Gland    327.4 Larval Trachea    291.975 Larval Carcass    219.7 Adult Head    143.5 Adult Eye    150.95 Adult Brain    231.2 Adult Thoracic-Abdominal Ganglion    165.4 Adult Crop    184.9 Adult Midgut    168.3 Adult Hindgut    161.4 Adult Malpighian Tubules    161.1 Adult Fat Body    140.8 Adult Salivary Gland    148.2 Adult Heart    114.3 Adult VirginFemale Spermatheca    221.8 Adult InseminatedFemale Spermatheca    237.5 Adult Ovary    440.5 Adult Testis    171.6 Adult Male Accessory Gland    296.8 Adult Carcass    94.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  509 Larval Midgut    133.5 Larval Hindgut    202.4 Larval Malpighian Tubules    160.2 Larval Fat Body    150.1 Larval Salivary Gland    327.4 Larval Trachea    291.975 Larval Carcass    219.7 Adult Head    143.5 Adult Eye    150.95 Adult Brain    231.2 Adult Thoracic-Abdominal Ganglion    165.4 Adult Crop    184.9 Adult Midgut    168.3 Adult Hindgut    161.4 Adult Malpighian Tubules    161.1 Adult Fat Body    140.8 Adult Salivary Gland    148.2 Adult Heart    114.3 Adult VirginFemale Spermatheca    221.8 Adult InseminatedFemale Spermatheca    237.5 Adult Ovary    440.5 Adult Testis    171.6 Adult Male Accessory Gland    296.8 Adult Carcass    94.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    509 Larval Midgut    133.5 Larval Hindgut    202.4 Larval Malpighian Tubules    160.2 Larval Fat Body    150.1 Larval Salivary Gland    327.4 Larval Trachea    291.975 Larval Carcass    219.7 Adult Head    143.5 Adult Eye    150.95 Adult Brain    231.2 Adult Thoracic-Abdominal Ganglion    165.4 Adult Crop    184.9 Adult Midgut    168.3 Adult Hindgut    161.4 Adult Malpighian Tubules    161.1 Adult Fat Body    140.8 Adult Salivary Gland    148.2 Adult Heart    114.3 Adult VirginFemale Spermatheca    221.8 Adult InseminatedFemale Spermatheca    237.5 Adult Ovary    440.5 Adult Testis    171.6 Adult Male Accessory Gland    296.8 Adult Carcass    94.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    509 Larval Midgut    133.5 Larval Hindgut    202.4 Larval Malpighian Tubules    160.2 Larval Fat Body    150.1 Larval Salivary Gland    327.4 Larval Trachea    291.975 Larval Carcass    219.7 Adult Head    143.5 Adult Eye    150.95 Adult Brain    231.2 Adult Thoracic-Abdominal Ganglion    165.4 Adult Crop    184.9 Adult Midgut    168.3 Adult Hindgut    161.4 Adult Malpighian Tubules    161.1 Adult Fat Body    140.8 Adult Salivary Gland    148.2 Adult Heart    114.3 Adult VirginFemale Spermatheca    221.8 Adult InseminatedFemale Spermatheca    237.5 Adult Ovary    440.5 Adult Testis    171.6 Adult Male Accessory Gland    296.8 Adult Carcass    94.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    143.5   NA  Eye    150.95   NA  Brain    231.2   509  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    165.4   NA  Crop    184.9   133.5  Midgut    168.3   202.4  Hindgut    161.4   160.2  Malpighian Tubules    161.1   150.1  Fat Body    140.8   327.4  Salivary Gland    148.2   NA  Heart    114.3   291.975  Trachea    NA   NA  VirginFemale Spermatheca    221.8   NA  InseminatedFemale Spermatheca    237.5   NA  Ovary    440.5   NA  Testis    171.6   NA  Male Accessory Gland    296.8   219.7  Carcass    94.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    32 central nervous system, pupae P8    14 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    24 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    40 ovary, mated 4-day female    34 testis, mated 4-day male    28 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (34) central nervous system, larvae L3  (32) central nervous system, pupae P8    14 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    24 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female  (40) ovary, mated 4-day female  (34) testis, mated 4-day male  (28) accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    32 central nervous system, pupae P8    14 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    24 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    40 ovary, mated 4-day female    34 testis, mated 4-day male    28 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    32 central nervous system, pupae P8    14 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    24 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    40 ovary, mated 4-day female    34 testis, mated 4-day male    28 accessory gland, mated 4-day male    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    32 central nervous system, pupae P8    14 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    24 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    40 ovary, mated 4-day female    34 testis, mated 4-day male    28 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (34) central nervous system, larvae L3  32 central nervous system, pupae P8    14 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    24 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female  (40) ovary, mated 4-day female  (34) testis, mated 4-day male  28 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    32 central nervous system, pupae P8    14 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    24 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    40 ovary, mated 4-day female    34 testis, mated 4-day male    28 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    34 central nervous system, larvae L3    32 central nervous system, pupae P8    14 head, virgin 1-day female    5 head, virgin 4-day female    6 head, virgin 20-day female    7 head, mated 1-day female    7 head, mated 4-day female    6 head, mated 20-day female    6 head, mated 1-day male    9 head, mated 4-day male    9 head, mated 20-day male    11 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    2 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    8 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    10 carcass, larvae L3 wandering    24 carcass, 1-day adult    5 carcass, 4-day adult    7 carcass, 20-day adult    6 ovary, virgin 4-day female    40 ovary, mated 4-day female    34 testis, mated 4-day male    28 accessory gland, mated 4-day male    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    80 embryo 04-06hr    64 embryo 06-08hr    58 embryo 08-10hr    54 embryo 10-12hr    49 embryo 12-14hr    31 embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    12 larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    13 adult male 30day    11 adult female 01day    18 adult female 05day    29 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (52) embryo 02-04hr  (80) embryo 04-06hr  (64) embryo 06-08hr  (58) embryo 08-10hr  (54) embryo 10-12hr  (49) embryo 12-14hr  (31) embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    12 larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr  (27) pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    13 adult male 30day    11 adult female 01day    18 adult female 05day  (29) adult female 30day  (30) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    80 embryo 04-06hr    64 embryo 06-08hr    58 embryo 08-10hr    54 embryo 10-12hr    49 embryo 12-14hr    31 embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    12 larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    13 adult male 30day    11 adult female 01day    18 adult female 05day    29 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    80 embryo 04-06hr    64 embryo 06-08hr    58 embryo 08-10hr    54 embryo 10-12hr    49 embryo 12-14hr    31 embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    12 larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    13 adult male 30day    11 adult female 01day    18 adult female 05day    29 adult female 30day    30 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    80 embryo 04-06hr    64 embryo 06-08hr    58 embryo 08-10hr    54 embryo 10-12hr    49 embryo 12-14hr    31 embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    12 larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    13 adult male 30day    11 adult female 01day    18 adult female 05day    29 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (52) embryo 02-04hr  (80) embryo 04-06hr  (64) embryo 06-08hr  (58) embryo 08-10hr  (54) embryo 10-12hr  (49) embryo 12-14hr  31 embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    12 larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr  27 pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    13 adult male 30day    11 adult female 01day    18 adult female 05day  29 adult female 30day  30 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    80 embryo 04-06hr    64 embryo 06-08hr    58 embryo 08-10hr    54 embryo 10-12hr    49 embryo 12-14hr    31 embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    12 larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    13 adult male 30day    11 adult female 01day    18 adult female 05day    29 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    52 embryo 02-04hr    80 embryo 04-06hr    64 embryo 06-08hr    58 embryo 08-10hr    54 embryo 10-12hr    49 embryo 12-14hr    31 embryo 14-16hr    23 embryo 16-18hr    16 embryo 18-20hr    10 embryo 20-22hr    10 embryo 22-24hr    12 larva L1    19 larva L2    18 larva L3 12hr old    14 larva L3 puffstage 1-2    13 larva L3 puffstage 3-6    16 larva L3 puffstage 7-9    20 white prepupae new    20 white prepupae 12hr    21 white prepupae 24hr    27 pupae 2d postWPP    17 pupae 3d postWPP    8 pupae 4d postWPP    6 adult male 01day    10 adult male 05day    13 adult male 30day    11 adult female 01day    18 adult female 05day    29 adult female 30day    30 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    40 embryonic 1182-4H    30 embryonic GM2    28 embryonic Kc167    21 embryonic S1    18 embryonic S3    28 leg disc CME L1    35 wing disc CME-W2    22 wing disc ML-DmD8    27 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    61 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    45 mixed discs ML-DmD4-c1    41 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    23 ovary fGS/OSS    35 ovary OSC    33 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (32) Schneider line 2 Sg4  (40) embryonic 1182-4H  (30) embryonic GM2  (28) embryonic Kc167    21 embryonic S1    18 embryonic S3  (28) leg disc CME L1  (35) wing disc CME-W2    22 wing disc ML-DmD8  (27) wing disc ML-DmD9  (32) wing disc ML-DmD16-c3  (32) wing disc ML-DmD21  (61) wing disc ML-DmD32    21 haltere disc ML-DmD17-c3  (40) eye-antennal disc ML-DmD11  (33) antennal disc ML-DmD20-c5  (45) mixed discs ML-DmD4-c1  (41) CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2  (27) tumorous blood cells mbn2    23 ovary fGS/OSS  (35) ovary OSC  (33) ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    40 embryonic 1182-4H    30 embryonic GM2    28 embryonic Kc167    21 embryonic S1    18 embryonic S3    28 leg disc CME L1    35 wing disc CME-W2    22 wing disc ML-DmD8    27 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    61 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    45 mixed discs ML-DmD4-c1    41 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    23 ovary fGS/OSS    35 ovary OSC    33 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    40 embryonic 1182-4H    30 embryonic GM2    28 embryonic Kc167    21 embryonic S1    18 embryonic S3    28 leg disc CME L1    35 wing disc CME-W2    22 wing disc ML-DmD8    27 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    61 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    45 mixed discs ML-DmD4-c1    41 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    23 ovary fGS/OSS    35 ovary OSC    33 ovary OSS    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    40 embryonic 1182-4H    30 embryonic GM2    28 embryonic Kc167    21 embryonic S1    18 embryonic S3    28 leg disc CME L1    35 wing disc CME-W2    22 wing disc ML-DmD8    27 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    61 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    45 mixed discs ML-DmD4-c1    41 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    23 ovary fGS/OSS    35 ovary OSC    33 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  32 Schneider line 2 Sg4  (40) embryonic 1182-4H  30 embryonic GM2  28 embryonic Kc167    21 embryonic S1    18 embryonic S3  28 leg disc CME L1  (35) wing disc CME-W2    22 wing disc ML-DmD8  27 wing disc ML-DmD9  32 wing disc ML-DmD16-c3  32 wing disc ML-DmD21  (61) wing disc ML-DmD32    21 haltere disc ML-DmD17-c3  (40) eye-antennal disc ML-DmD11  (33) antennal disc ML-DmD20-c5  (45) mixed discs ML-DmD4-c1  (41) CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2  27 tumorous blood cells mbn2    23 ovary fGS/OSS  (35) ovary OSC  (33) ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    40 embryonic 1182-4H    30 embryonic GM2    28 embryonic Kc167    21 embryonic S1    18 embryonic S3    28 leg disc CME L1    35 wing disc CME-W2    22 wing disc ML-DmD8    27 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    61 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    45 mixed discs ML-DmD4-c1    41 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    23 ovary fGS/OSS    35 ovary OSC    33 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    32 Schneider line 2 Sg4    40 embryonic 1182-4H    30 embryonic GM2    28 embryonic Kc167    21 embryonic S1    18 embryonic S3    28 leg disc CME L1    35 wing disc CME-W2    22 wing disc ML-DmD8    27 wing disc ML-DmD9    32 wing disc ML-DmD16-c3    32 wing disc ML-DmD21    61 wing disc ML-DmD32    21 haltere disc ML-DmD17-c3    40 eye-antennal disc ML-DmD11    33 antennal disc ML-DmD20-c5    45 mixed discs ML-DmD4-c1    41 CNS ML-DmBG1-c1    24 CNS ML-DmBG2-c2    27 tumorous blood cells mbn2    23 ovary fGS/OSS    35 ovary OSC    33 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3  (29) Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  26 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3  29 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  26 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    7 heat shock, 4-day adult    15 Cadmium 50 mM 6 hrs, larvae L3    14 Cadmium 50 mM 12 hrs, larvae L3    12 Cadmium 50 mM 48 hrs, 4-day adult    16 Cadmium 100 mM 48 hrs, 4-day adult    23 Copper 0.5 mM 12 hrs, larvae L3    13 Copper 15 mM 48 hrs, 4-day adult    9 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    11 Ethanol 2.5% 3 hrs, larvae L3    29 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    12 Caffeine 1.5 mg/ml 4 hrs, larvae L3    13 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    25 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    26 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    13 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD22754 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014366 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2925-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 noiGD9855 lethal | embryonic stage | recessive noiA noiC noiD lethal | recessive noij3E7 viable noi20 viable | female noi1 noi2 noi12 viable | male noi1 noi2 noi12 Sterility Allele female sterile | cold sensitive noi1 noi2 noi12 noi22 male sterile | recessive noi1 noi2 noi12 Other Phenotypes Allele visible noi20 wild-type noi+t3.6 Phenotype manifest in Allele dorsal appendage noi1 noi2 noi22 egg noi1 noi2 noi22 germline cell | male noi1 noi12 noi2 head & macrochaeta | dorsal noi20 medial triple row noi20 nurse cell noi1 noi2 noi22 nurse cell & nucleus noi1 noi2 noi22 oocyte nucleus noi1 noi2 noi22 sex comb noi20 thorax & macrochaeta | dorsal noi20
Classical Alleles ( 12 )
For All Classical Alleles Show
Allele of noi Class Mutagen Stocks Known lesion noif05442 piggyBac transposase 2 -- noiDP00123 1 -- noif05270 piggyBac transposase 1 -- noij3E7 P-element activity 1 -- noi12 cold sensitive hypomorphic allele - genetic evidence Delta2-3 0 -- noi1 hypomorphic allele - genetic evidence Delta2-3 0 Yes noi20 Delta2-3 0 Yes noi22 Delta2-3 0 Yes noi2 cold sensitive hypomorphic allele - genetic evidence Delta2-3 0 Yes noiA Delta2-3 0 Yes noiC Delta2-3 0 Yes noiD Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of noi Class Mutagen Stocks Known lesion noiGD9855 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes noiHMS00163 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes noiKK101842 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes noi+t3.6 in vitro construct - genomic fragment 0 Yes noiNIG.2925R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC549 (Christensen et al., 2008.6.11) Df(3R)Exel6144 (Ryder, 2004.4.26) Df(3R)noi-B (Meyer et al., 1998, Buffin et al., 2007, Meyer et al., 1998) Df(3R)noi-C (Meyer et al., 1998)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9855} NA P{KK101842} NA P{NIG.2925R} NA P{TRiP.HMS00163} NA characterization construct P{noi+3.6} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}noi1 No P{lacW}noi2 No P{lacW}noij3E7 No miscellaneous insertions P{?lacW}noi20 NA P{?lacW}noi22 NA P{lacW-Δ12.M}noi12 NA PBac{WH}noif05270 NA PBac{WH}noif05442 NA insertion of mobile activating element P{Mae-UAS.6.11}noiDP00123 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
fertilization inferred from mutant phenotype (assigned by UniProtKB) (Meyer et al., 1998) mitosis inferred from mutant phenotype (Ducat et al., 2008) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) positive regulation of NFAT protein import into nucleus inferred from mutant phenotype (Gwack et al., 2007) regulation of cell cycle inferred from direct assay (Guest et al., 2011)
Cellular Component
CV term Evidence References
catalytic step 2 spliceosome inferred from direct assay (Herold et al., 2009) precatalytic spliceosome inferred from direct assay (Herold et al., 2009)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR000690 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR000690, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
mRNA splicing, via spliceosome inferred by curator from GO:0071011|GO:0071013 (Herold et al., 2009) inferred from sequence or structural similarity (Laget et al., 1996) inferred from sequence or structural similarity with NCBI_gi:1082798 (FlyBase, 1992-) inferred from sequence or structural similarity with NCBI:NP_006793 AND inferred from sequence or structural similarity with Saccharomyces PRP9 (Mount and Salz, 2000) inferred from sequence or structural similarity with UniProtKB:Q12874 (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15)
Cellular Component
CV term Evidence References
spliceosomal complex inferred from sequence or structural similarity (Laget et al., 1996) inferred from sequence or structural similarity with NCBI_gi:1082798 (FlyBase, 1992-) inferred from sequence or structural similarity with UniProtKB:Q12874 (assigned by UniProtKB) (Swiss-Prot Project Members, 2003.9.15) U2 snRNP inferred from sequence or structural similarity with NCBI:NP_006793 AND inferred from sequence or structural similarity with Saccharomyces PRP9 (Mount and Salz, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
noi - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - Arp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - Arpc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - CG10688 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - CG10754 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) noi - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - CG13321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - CG1444 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - CG15098 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - CG16734 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - CG16941 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) noi - CG2064 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - CG2065 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - CG33303 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - CG42358 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - CG9114 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - HDAC6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - LRP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - Mec2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - Mppe anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - Prosα6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - R anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - Rab6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - Rpn3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - Sc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - Spt-I anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - Tapδ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - Tm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - ana2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - crn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - eIF-5A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - l(2)37Cb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - lace anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) noi - ref(2)P anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions noi allele Gene References noi2 Sxl (Cline et al., 1999) noi+t3.6 Sxl (Cline et al., 1999) noiD Sxl (Cline et al., 1999) unspecified snf (Cline et al., 1999)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 65884 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0014366 DroID - A comprehensive database of gene and protein interactions. • FBgn0014366 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40678
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG68GWP2 Dipteran inclusive ortholog search EOG6THW2G Insect inclusive ortholog search EOG6Z091Z Arthropod inclusive ortholog search EOG6FN2ZZ Metazoa inclusive ortholog search EOG612ZZS
Orthologs in Drosophila Species (EOG68GWP2)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\noi     Drosophila simulans   Dsim\GD19603 Y   Drosophila sechellia   Dsec\GM10615 Y   Drosophila sechellia   Dsec\GM15455     Drosophila erecta   Dere\GG10938 Y   Drosophila yakuba   Dyak\GE24160 Y   Drosophila ananassae   Dana\GF20764 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA15523 Y   Drosophila persimilis   Dper\GL21522 Y   Drosophila willistoni   Dwil\GK22655 Y   Drosophila virilis   Dvir\GJ24013 Y   Drosophila mojavensis   Dmoj\GI23921 Y   Drosophila grimshawi   Dgri\GH17377 Y
Orthologs in non-Drosophila Dipterans (EOG6THW2G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL015244   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012348   Anopheles gambiae Malaria mosquito  Agam\AGAP003085   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002728
Orthologs in non-Dipteran Insects (EOG6Z091Z)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\SF3A3   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007268   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH11975   Atta cephalotes Leafcutter ant  Acep\ACEP23676   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18573   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21783   Linepithema humile Argentine ant  Lhum\LH12891   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13270   Solenopsis invicta Red fire ant  Sinv\SINV16013   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000249   Bombyx mori Silkmoth  Bmor\BGIBMGA006358   Pediculus humanus Human body louse  Phum\PHUM258680   Tribolium castaneum Red flour beetle  Tcas\TC001034
Orthologs in non-Insect Arthropods (EOG6FN2ZZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\MYC   Ixodes scapularis Deer tick  Isca\ISCW010835
Orthologs in non-Arthropod Metazoa (EOG612ZZS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\T13H5.4   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007675gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_016711gn   Danio rerio Zebrafish  Drer\sf3a3   Xenopus tropicalis Western clawed frog  Xtro\sf3a3   Gallus gallus Domestic chicken  Ggal\SF3A3   Mus musculus House mouse  Mmus\Sf3a3   Rattus norvegicus Norway rat  Rnor\Sf3a3   Homo sapiens Human  Hsap\SF3A3
Human Orthologs (1)
Gene OMIM HGNC Hsap\SF3A3
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD19603 Drosophila sechellia Dsec\GM10615 Drosophila erecta Dere\GG10938 Drosophila yakuba Dyak\GE24160 Drosophila ananassae Dana\GF20764 Drosophila pseudoobscura pseudoobscura Dpse\GA15523 Drosophila persimilis Dper\GL21522 Drosophila willistoni Dwil\GK22655 Drosophila virilis Dvir\GJ24013 Drosophila mojavensis Dmoj\GI23921 Drosophila grimshawi Dgri\GH17377
Stocks & Reagents
Stocks Listed in FlyBase ( 9 )
Bloomington	34845 y1 sc* v1; P{TRiP.HMS00163}attP2 18865 w1118; PBac{WH}noif05442/TM6B, Tb1 21799 y1 w67c23; P{Mae-UAS.6.11}noiDP00123/TM3, Sb1 10214 w1118; P{lacW}noij3E7 Vha26j3E7/TM3, P{ftz/lacC}SC1, ryRK Sb1 Ser1
Harvard	- PBac{WH}noif05270 - PBac{WH}noif05442
VDRC	v105354 P{KK101842}VIE-260B v20943 w1118; P{GD9855}v20943 v20945 w1118; P{GD9855}v20945/TM3
Genomic Clones ( 2 )
	BACR03P13 BACR24O24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 36 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD22754
Other clones	DPiM_LD22754
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM05889 GM28321 LD03655 LD16525 LD21017 LD26167 LD38124 LD42294 LP09301 RE05427 RE08272 RE15255 RE24964 RE44965 RH39890 RH52392 SD16753 SD22686 SD26903
Other clones	16103 58568 191370 214407.61 CK01.60A.F5 CK01.71A.E1 EK053602 EK056417 EK063323 EK119807 EK175801 EK292807 EK293843 EP15654 FGM224A04
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0014366 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40678
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: noi l(3)j3E7 (Spradling et al., 1999)
Additional comments
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in a long metaphase spindle with misaligned chromosomes when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) Identified as a potential component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells. (Nybakken et al., 2005) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) Hypomorphic alleles reveal multiple roles of noi for the survival and differentiation of male germ cells, the differentiation of female germ cells and the development of several adult structures. (Meyer et al., 1998) Complete loss of noi function results in lethality at the end of embryogenesis, without obvious morphological defects. (Meyer et al., 1998) noi is required for the maintenance of the XY male germline stem cells and the few escaping germ cells fail to develop. (Pauli et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057766 RefSeq (Proteins) • NP_477114 DDBJ / EMBL / GenBank • AA441548 AA820123 AAF51999 AAK93100 AC009538 AI455297 AJ223042 AQ026316 AY051676 CAA11045 CZ487902 CZ488017 CZ488018 Entrez Gene - A searchable database of RefSeq genes. • 40678 UniProtKB/Swiss-Prot • O46106
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-type matrin (IPR000690) Zinc finger, C2H2-like (IPR015880) Domain of unknown function DUF3449 (IPR024598) Splicing factor SF3a60 binding domain (IPR021966) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD22754
Linkouts
	BioGRID - A database of protein and genetic interactions • 65884 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0014366 DroID - A comprehensive database of gene and protein interactions. • FBgn0014366 DRSC - Results from RNAi screens. • FBgn0014366 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0014366 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG2925-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0014366 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 40678 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 40678 modMine - Data generated by the modENCODE project. • FBgn0014366
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG2925 (Mount and Salz, 2000, Nybakken et al., 2005, Goshima et al., 2007, Ducat et al., 2008, Keleman et al., 2009.8.5, Herold et al., 2009, Ni et al., 2011.7.19) l(3)j3E7 (BDGP Project Members, 1994-1999, ) ms3225 (Laget et al., 1996) noi (Meyer et al., 1998, Nybakken et al., 2005, Goshima et al., 2007, Christensen et al., 2008.6.11, Somma et al., 2008, Guest et al., 2011, Buffin et al., 2007, Farny et al., 2008, Font-Burgada et al., 2008, Herold et al., 2009, Xi et al., 2008, Japanese National Institute of Genetics, 2012.5.21) Noi (Gwack et al., 2007) SF3A3 (Somma et al., 2008) SF3a60 (Cline et al., 1999) U2
Name Synonym	noisette (Pauli, 1998.1.5, Pauli et al., 1995, Buffin et al., 2007) Noisette (Ducat et al., 2008)
Secondary FlyBase IDs
	FBgn0011357
References ( 46 )
Generate a list of	All references relating to this gene ( 46 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 7 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Guest et al., 2011, BMC Syst. Biol. 5(1): 65 A protein network-guided screen for cell cycle regulators in Drosophila. [FBrf0213913] Show all research papers ...