Gene Dmel\tilB

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General Information

Symbol

Dmel\tilB

Species

D. melanogaster

Name

touch insensitive larva B

Annotation symbol

CG14620

Feature type

protein_coding_gene

FlyBase ID

FBgn0014395

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

20B1-20B1

Sequence location

X:21,851,781..21,853,303 [+]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene touch insensitive larva B is referred to in FlyBase by the symbol tilB (CG14620, FBgn0014395). It has the cytological map location 20B1. Its sequence location is X:21851781..21853303. Its molecular function is described as protein binding. It is involved in the biological processes: sensory perception of sound; male courtship behavior, veined wing generated song production; detection of mechanical stimulus involved in sensory perception of sound. 3 alleles are reported. The phenotypes of these alleles are annotated with: adult antennal nerve; spermatid axoneme; arista; cilium. It has one annotated transcript and one annotated polypeptide.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

20B1-20B1

Limits computationally determined from genome sequence between P{EP}CG1702^EP1525 and P{EP}EP1465&P{EP}CG1486^EP1192

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

(Kernan et al., 1995)

Left of (cM)

Right of (cM)

Notes

Maps between flam and wap.

(Kavlie et al., 2003)

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\tilB for information on other features

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

tilB-RA

FBtr0077345

NM_134616

1228

395

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

tilB-PA

FBpp0077037

45.6

395

6.33

NP_608460

AAF50954

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Leucine-rich repeat (IPR001611)

U2A'/phosphoprotein 32 family A, C-terminal (IPR003603)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Maps to

Does NOT map to

Identified with

AT10149

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

deletion

tilB[2]
X:21,852,872..21,853,084

comment=Mutation is an in-frame deletion in exon 3
evidence=experimental

(Kavlie et al., 2005)

point mutation

tilB[1]
X:21,851,852..21,852,700

comment=Mutation is in the second exon. Nonsense mutation leading to premature stop codon.
evidence=experimental
reported_pr_change=??@

(Kavlie et al., 2005)

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

5300

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0014395

Alleles & Phenotypes

Summary of Allele Phenotypes

Other Phenotypes

Allele

behavior defective | larval stage

courtship defective | recessive

song defective

auditory system defective

tilB²

auditory system defective | recessive

locomotor behavior defective

touch sensitivity defective

touch sensitivity defective | recessive

Sterility

Allele

male sterile | recessive

Phenotype manifest in

Allele

adult antennal nerve

spermatid axoneme

arista

tilB²

cilium

tilB²

Classical Alleles ( 2 )

For All Classical Alleles Show

Allele of tilB	Class	Mutagen	Stocks	Known lesion
tilB¹		X ray	0	Yes
tilB²		X ray	0	Yes

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of tilB	Class	Mutagen	Stocks	Known lesion
tilB^GD8381		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Useful deficiency

Df(1)D43L1

Df(1)HM430

Useful duplication

Dp(1;Y)y⁺mal¹⁷¹

Disrupted in

Df(1)16-2-13

(Kernan et al., 1994)

Df(1)Exel6255

(Ryder, 2004.4.26)

Df(1)GA33

(Kernan et al., 1994)

Not disrupted in

Df(1)B57

(Kernan et al., 1994)

Df(1)DCB1-35c

(Kernan et al., 1994)

Df(1)EA113

(Kernan et al., 1994)

Df(1)HM430

(Kernan et al., 1994)

Df(1)S54

(Kernan et al., 1994)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD8381}

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Sperm from tilB mutants are non-motile and arrested at the last stage of maturation. The nine-fold radial symmetry of the sperm flagella is disrupted.

(Kernan et al., 1995)

Gene Ontology: Function, Process & Cellular Component ( 4 )

Molecular Function

CV term

Evidence

References

protein binding

inferred from electronic annotation with InterPro:IPR001611

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

detection of mechanical stimulus involved in sensory perception of sound

inferred from mutant phenotype

(Gopfert and Robert, 2003)

male courtship behavior, veined wing generated song production

inferred from mutant phenotype

(Tauber and Eberl, 2001)

sensory perception of sound

inferred from mutant phenotype

(Eberl et al., 2000)

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

tilB allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

Orthologs

Genome-wide drosophilid orthologs

Dana\GF21000

Dere\GG19742

Dgri\GH17707

Dmoj\GI15449

Dper\GL13315

Dpse\GA22833

Dsec\GM11728

Dsim\GD24889

Dvir\GJ19165

Dwil\GK16417

Dyak\GE17937

Curated drosophilid orthologs

Dpse\GA13120

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000021955
Anopheles gambiae (Ensembl)
ENSBTAP00000013949
Bos taurus (Ensembl)
ENSCAFP00000001566
Canis familiaris (Ensembl)
NEWSINFRUP00000138801
Takifugu rubripes (Ensembl)
ENSGALP00000026148
Gallus gallus (Ensembl)
ENSP00000250173
Homo sapiens (Ensembl)
ENSMMUP00000020530
Macaca mulatta (Ensembl)
ENSMODP00000001444
Monodelphis domestica (Ensembl)
ENSPTRP00000035210
Pan troglodytes (Ensembl)
ENSRNOP00000007250
Rattus norvegicus (Ensembl)
GSTENP00012405001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000049805
Xenopus tropicalis (Ensembl)
ZDB-GENE-040827-2
Danio rerio (Zfin)
MGI:1859553
Mus musculus (Informatics)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 2 )

VDRC

v24881

w¹¹¹⁸; P{GD8381}v24881

v24883

w¹¹¹⁸; P{GD8381}v24883

Genomic Clones ( 2 )

cDNA Clones ( 3 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones