Gene Dmel\CG11899

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General Information

Symbol

Dmel\CG11899

Species

D. melanogaster

Name

Annotation symbol

CG11899

Feature type

protein_coding_gene

FlyBase ID

FBgn0014427

Gene Model Status

Current

Stock availability

4 publicly available

Also Known As

ESTS:39C10S

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

99A1-99A1

Sequence location

3R:25,026,176..25,027,492 [+]

Genomic Maps

Select View:

Summary Information

Automatically generated summary

See sections below for more information

This gene is referred to in FlyBase by the symbol Dmel\CG11899 (FBgn0014427). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: O-phospho-L-serine:2-oxoglutarate aminotransferase activity. It is reported to be involved in the biological process: pyridoxine biosynthetic process; L-serine biosynthetic process. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Aminotransferase class-V pyridoxal-phosphate binding site; Aminotransferase, class V/Cysteine desulfurase; Phosphoserine aminotransferase; Phosphoserine aminotransferase, subgroup; Pyridoxal phosphate-dependent transferase; Pyridoxal phosphate-dependent transferase, major region, subdomain 1; Pyridoxal phosphate-dependent transferase, major region, subdomain 2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed during late larval stages, at stages throughout the pupal period. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval midgut, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult midgut, larval/adult hindgut, adult Malpighian tubules, adult salivary gland, larval trachea, adult ovary, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1625613_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of CG11899. Gene sequence location is 3R:25026176..25027492.

User Contributed Data

Beta version, feedback welcome

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

99A1-99A1

Limits computationally determined from genome sequence between P{EP}EP3390^EP3390 and P{PZ}l(3)04708⁰⁴⁷⁰⁸

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

98F-98F

(determined by in situ hybridisation)

(Louis et al., 1997)

98F-98F

(determined by in situ hybridisation)

(EDGP Project Members, 1994-)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\CG11899 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

CG11899-RA

FBtr0085390

NM_143789

1176

364

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

CG11899-PA

FBpp0084759

39.5

364

8.66

NP_652046

AAF56874

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Aminotransferase, class V/Cysteine desulfurase (IPR000192)

Phosphoserine aminotransferase, subgroup (IPR003248)

Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (IPR015421)

Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (IPR015422)

Pyridoxal phosphate-dependent transferase (IPR015424)

Aminotransferase class-V pyridoxal-phosphate binding site (IPR020578)

Phosphoserine aminotransferase (IPR022278)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9VAN0

UniProtKB/TrEMBL

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

(Fisher et al., 2012)

Comment:maternally deposited

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval midgut, adult heart, larval/adult fat body, adult spermathecae, adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult crop, adult midgut, larval/adult hindgut, adult Malpighian tubules, adult salivary gland, larval trachea, adult ovary, larval carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		83.425
Larval Midgut		1548
Larval Hindgut		229.5
Larval Malpighian Tubules		43.3
Larval Fat Body		1750.5
Larval Salivary Gland		48.7
Larval Trachea		160.05
Larval Carcass		200.225
Adult Head		724.7
Adult Eye		543.125
Adult Brain		71.2
Adult Thoracic-Abdominal Ganglion		72.8
Adult Crop		462.7
Adult Midgut		375.3
Adult Hindgut		284.3
Adult Malpighian Tubules		205.2
Adult Fat Body		1334
Adult Salivary Gland		163.3
Adult Heart		751.7
Adult VirginFemale Spermatheca		1624.5
Adult InseminatedFemale Spermatheca		898.5
Adult Ovary		407
Adult Testis		29.9
Adult Male Accessory Gland		31.9
Adult Carcass		602.5
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		83.425
Larval Midgut		(1548)
Larval Hindgut		229.5
Larval Malpighian Tubules		43.3
Larval Fat Body		(1750.5)
Larval Salivary Gland		48.7
Larval Trachea		160.05
Larval Carcass		200.225
Adult Head		(724.7)
Adult Eye		(543.125)
Adult Brain		71.2
Adult Thoracic-Abdominal Ganglion		72.8
Adult Crop		462.7
Adult Midgut		375.3
Adult Hindgut		284.3
Adult Malpighian Tubules		205.2
Adult Fat Body		(1334)
Adult Salivary Gland		163.3
Adult Heart		(751.7)
Adult VirginFemale Spermatheca		(1624.5)
Adult InseminatedFemale Spermatheca		(898.5)
Adult Ovary		407
Adult Testis		29.9
Adult Male Accessory Gland		31.9
Adult Carcass		(602.5)
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		83.425
Larval Midgut		(1548)
Larval Hindgut		229.5
Larval Malpighian Tubules		43.3
Larval Fat Body		(1750.5)
Larval Salivary Gland		48.7
Larval Trachea		160.05
Larval Carcass		200.225
Adult Head		724.7
Adult Eye		543.125
Adult Brain		71.2
Adult Thoracic-Abdominal Ganglion		72.8
Adult Crop		462.7
Adult Midgut		375.3
Adult Hindgut		284.3
Adult Malpighian Tubules		205.2
Adult Fat Body		(1334)
Adult Salivary Gland		163.3
Adult Heart		751.7
Adult VirginFemale Spermatheca		(1624.5)
Adult InseminatedFemale Spermatheca		898.5
Adult Ovary		407
Adult Testis		29.9
Adult Male Accessory Gland		31.9
Adult Carcass		602.5
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		83.425
Larval Midgut		1548
Larval Hindgut		229.5
Larval Malpighian Tubules		43.3
Larval Fat Body		1750.5
Larval Salivary Gland		48.7
Larval Trachea		160.05
Larval Carcass		200.225
Adult Head		724.7
Adult Eye		543.125
Adult Brain		71.2
Adult Thoracic-Abdominal Ganglion		72.8
Adult Crop		462.7
Adult Midgut		375.3
Adult Hindgut		284.3
Adult Malpighian Tubules		205.2
Adult Fat Body		1334
Adult Salivary Gland		163.3
Adult Heart		751.7
Adult VirginFemale Spermatheca		1624.5
Adult InseminatedFemale Spermatheca		898.5
Adult Ovary		407
Adult Testis		29.9
Adult Male Accessory Gland		31.9
Adult Carcass		602.5
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		83.425
Larval Midgut		1548
Larval Hindgut		229.5
Larval Malpighian Tubules		43.3
Larval Fat Body		1750.5
Larval Salivary Gland		48.7
Larval Trachea		160.05
Larval Carcass		200.225
Adult Head		724.7
Adult Eye		543.125
Adult Brain		71.2
Adult Thoracic-Abdominal Ganglion		72.8
Adult Crop		462.7
Adult Midgut		375.3
Adult Hindgut		284.3
Adult Malpighian Tubules		205.2
Adult Fat Body		1334
Adult Salivary Gland		163.3
Adult Heart		751.7
Adult VirginFemale Spermatheca		1624.5
Adult InseminatedFemale Spermatheca		898.5
Adult Ovary		407
Adult Testis		29.9
Adult Male Accessory Gland		31.9
Adult Carcass		602.5
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		83.425
Larval Midgut		(1548)
Larval Hindgut		229.5
Larval Malpighian Tubules		43.3
Larval Fat Body		(1750.5)
Larval Salivary Gland		48.7
Larval Trachea		160.05
Larval Carcass		200.225
Adult Head		724.7
Adult Eye		543.125
Adult Brain		71.2
Adult Thoracic-Abdominal Ganglion		72.8
Adult Crop		462.7
Adult Midgut		375.3
Adult Hindgut		284.3
Adult Malpighian Tubules		205.2
Adult Fat Body		(1334)
Adult Salivary Gland		163.3
Adult Heart		751.7
Adult VirginFemale Spermatheca		(1624.5)
Adult InseminatedFemale Spermatheca		(898.5)
Adult Ovary		407
Adult Testis		29.9
Adult Male Accessory Gland		31.9
Adult Carcass		602.5
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		83.425
Larval Midgut		1548
Larval Hindgut		229.5
Larval Malpighian Tubules		43.3
Larval Fat Body		(1750.5)
Larval Salivary Gland		48.7
Larval Trachea		160.05
Larval Carcass		200.225
Adult Head		724.7
Adult Eye		543.125
Adult Brain		71.2
Adult Thoracic-Abdominal Ganglion		72.8
Adult Crop		462.7
Adult Midgut		375.3
Adult Hindgut		284.3
Adult Malpighian Tubules		205.2
Adult Fat Body		1334
Adult Salivary Gland		163.3
Adult Heart		751.7
Adult VirginFemale Spermatheca		1624.5
Adult InseminatedFemale Spermatheca		898.5
Adult Ovary		407
Adult Testis		29.9
Adult Male Accessory Gland		31.9
Adult Carcass		602.5
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		83.425
Larval Midgut		1548
Larval Hindgut		229.5
Larval Malpighian Tubules		43.3
Larval Fat Body		1750.5
Larval Salivary Gland		48.7
Larval Trachea		160.05
Larval Carcass		200.225
Adult Head		724.7
Adult Eye		543.125
Adult Brain		71.2
Adult Thoracic-Abdominal Ganglion		72.8
Adult Crop		462.7
Adult Midgut		375.3
Adult Hindgut		284.3
Adult Malpighian Tubules		205.2
Adult Fat Body		1334
Adult Salivary Gland		163.3
Adult Heart		751.7
Adult VirginFemale Spermatheca		1624.5
Adult InseminatedFemale Spermatheca		898.5
Adult Ovary		407
Adult Testis		29.9
Adult Male Accessory Gland		31.9
Adult Carcass		602.5
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	724.7
NA	Eye	543.125
NA	Brain	71.2
83.425	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	72.8
NA	Crop	462.7
1548	Midgut	375.3
229.5	Hindgut	284.3
43.3	Malpighian Tubules	205.2
1750.5	Fat Body	1334
48.7	Salivary Gland	163.3
NA	Heart	751.7
160.05	Trachea	NA
NA	VirginFemale Spermatheca	1624.5
NA	InseminatedFemale Spermatheca	898.5
NA	Ovary	407
NA	Testis	29.9
NA	Male Accessory Gland	31.9
200.225	Carcass	602.5

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		23
central nervous system, larvae L3		16
central nervous system, pupae P8		7
head, virgin 1-day female		37
head, virgin 4-day female		22
head, virgin 20-day female		75
head, mated 1-day female		23
head, mated 4-day female		43
head, mated 20-day female		50
head, mated 1-day male		27
head, mated 4-day male		30
head, mated 20-day male		51
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		44
digestive system, larvae L3 wandering		27
digestive system, 1-day adult		30
digestive system, 4-day adult		13
digestive system, 20-day adult		17
fat body, larvae L3 wandering		13
fat body, white prepupae		234
fat body, pupae P8		62
carcass, larvae L3 wandering		38
carcass, 1-day adult		26
carcass, 4-day adult		25
carcass, 20-day adult		39
ovary, virgin 4-day female		37
ovary, mated 4-day female		25
testis, mated 4-day male		15
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		23
central nervous system, larvae L3		16
central nervous system, pupae P8		7
head, virgin 1-day female		(37)
head, virgin 4-day female		22
head, virgin 20-day female		(75)
head, mated 1-day female		23
head, mated 4-day female		(43)
head, mated 20-day female		(50)
head, mated 1-day male		(27)
head, mated 4-day male		(30)
head, mated 20-day male		(51)
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		(44)
digestive system, larvae L3 wandering		(27)
digestive system, 1-day adult		(30)
digestive system, 4-day adult		13
digestive system, 20-day adult		17
fat body, larvae L3 wandering		13
fat body, white prepupae		(234)
fat body, pupae P8		(62)
carcass, larvae L3 wandering		(38)
carcass, 1-day adult		26
carcass, 4-day adult		25
carcass, 20-day adult		(39)
ovary, virgin 4-day female		(37)
ovary, mated 4-day female		25
testis, mated 4-day male		15
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		23
central nervous system, larvae L3		16
central nervous system, pupae P8		7
head, virgin 1-day female		37
head, virgin 4-day female		22
head, virgin 20-day female		75
head, mated 1-day female		23
head, mated 4-day female		43
head, mated 20-day female		50
head, mated 1-day male		27
head, mated 4-day male		30
head, mated 20-day male		51
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		44
digestive system, larvae L3 wandering		27
digestive system, 1-day adult		30
digestive system, 4-day adult		13
digestive system, 20-day adult		17
fat body, larvae L3 wandering		13
fat body, white prepupae		(234)
fat body, pupae P8		62
carcass, larvae L3 wandering		38
carcass, 1-day adult		26
carcass, 4-day adult		25
carcass, 20-day adult		39
ovary, virgin 4-day female		37
ovary, mated 4-day female		25
testis, mated 4-day male		15
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		23
central nervous system, larvae L3		16
central nervous system, pupae P8		7
head, virgin 1-day female		37
head, virgin 4-day female		22
head, virgin 20-day female		75
head, mated 1-day female		23
head, mated 4-day female		43
head, mated 20-day female		50
head, mated 1-day male		27
head, mated 4-day male		30
head, mated 20-day male		51
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		44
digestive system, larvae L3 wandering		27
digestive system, 1-day adult		30
digestive system, 4-day adult		13
digestive system, 20-day adult		17
fat body, larvae L3 wandering		13
fat body, white prepupae		234
fat body, pupae P8		62
carcass, larvae L3 wandering		38
carcass, 1-day adult		26
carcass, 4-day adult		25
carcass, 20-day adult		39
ovary, virgin 4-day female		37
ovary, mated 4-day female		25
testis, mated 4-day male		15
accessory gland, mated 4-day male		4
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		23
central nervous system, larvae L3		16
central nervous system, pupae P8		7
head, virgin 1-day female		37
head, virgin 4-day female		22
head, virgin 20-day female		75
head, mated 1-day female		23
head, mated 4-day female		43
head, mated 20-day female		50
head, mated 1-day male		27
head, mated 4-day male		30
head, mated 20-day male		51
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		44
digestive system, larvae L3 wandering		27
digestive system, 1-day adult		30
digestive system, 4-day adult		13
digestive system, 20-day adult		17
fat body, larvae L3 wandering		13
fat body, white prepupae		234
fat body, pupae P8		62
carcass, larvae L3 wandering		38
carcass, 1-day adult		26
carcass, 4-day adult		25
carcass, 20-day adult		39
ovary, virgin 4-day female		37
ovary, mated 4-day female		25
testis, mated 4-day male		15
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		23
central nervous system, larvae L3		16
central nervous system, pupae P8		7
head, virgin 1-day female		(37)
head, virgin 4-day female		22
head, virgin 20-day female		(75)
head, mated 1-day female		23
head, mated 4-day female		(43)
head, mated 20-day female		(50)
head, mated 1-day male		27
head, mated 4-day male		30
head, mated 20-day male		(51)
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		(44)
digestive system, larvae L3 wandering		27
digestive system, 1-day adult		30
digestive system, 4-day adult		13
digestive system, 20-day adult		17
fat body, larvae L3 wandering		13
fat body, white prepupae		(234)
fat body, pupae P8		(62)
carcass, larvae L3 wandering		(38)
carcass, 1-day adult		26
carcass, 4-day adult		25
carcass, 20-day adult		(39)
ovary, virgin 4-day female		(37)
ovary, mated 4-day female		25
testis, mated 4-day male		15
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		23
central nervous system, larvae L3		16
central nervous system, pupae P8		7
head, virgin 1-day female		37
head, virgin 4-day female		22
head, virgin 20-day female		75
head, mated 1-day female		23
head, mated 4-day female		43
head, mated 20-day female		50
head, mated 1-day male		27
head, mated 4-day male		30
head, mated 20-day male		51
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		44
digestive system, larvae L3 wandering		27
digestive system, 1-day adult		30
digestive system, 4-day adult		13
digestive system, 20-day adult		17
fat body, larvae L3 wandering		13
fat body, white prepupae		(234)
fat body, pupae P8		62
carcass, larvae L3 wandering		38
carcass, 1-day adult		26
carcass, 4-day adult		25
carcass, 20-day adult		39
ovary, virgin 4-day female		37
ovary, mated 4-day female		25
testis, mated 4-day male		15
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		23
central nervous system, larvae L3		16
central nervous system, pupae P8		7
head, virgin 1-day female		37
head, virgin 4-day female		22
head, virgin 20-day female		75
head, mated 1-day female		23
head, mated 4-day female		43
head, mated 20-day female		50
head, mated 1-day male		27
head, mated 4-day male		30
head, mated 20-day male		51
salivary gland, larvae L3 wandering		4
salivary gland, white prepupae		44
digestive system, larvae L3 wandering		27
digestive system, 1-day adult		30
digestive system, 4-day adult		13
digestive system, 20-day adult		17
fat body, larvae L3 wandering		13
fat body, white prepupae		234
fat body, pupae P8		62
carcass, larvae L3 wandering		38
carcass, 1-day adult		26
carcass, 4-day adult		25
carcass, 20-day adult		39
ovary, virgin 4-day female		37
ovary, mated 4-day female		25
testis, mated 4-day male		15
accessory gland, mated 4-day male		4
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed during late larval stages, at stages throughout the pupal period.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		60
embryo 02-04hr		6
embryo 04-06hr		2
embryo 06-08hr		1
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		1
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		5
larva L1		28
larva L2		62
larva L3 12hr old		43
larva L3 puffstage 1-2		22
larva L3 puffstage 3-6		78
larva L3 puffstage 7-9		180
white prepupae new		255
white prepupae 12hr		215
white prepupae 24hr		211
pupae 2d postWPP		146
pupae 3d postWPP		48
pupae 4d postWPP		39
adult male 01day		65
adult male 05day		40
adult male 30day		48
adult female 01day		107
adult female 05day		106
adult female 30day		118
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(60)
embryo 02-04hr		6
embryo 04-06hr		2
embryo 06-08hr		1
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		1
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		5
larva L1		(28)
larva L2		(62)
larva L3 12hr old		(43)
larva L3 puffstage 1-2		22
larva L3 puffstage 3-6		(78)
larva L3 puffstage 7-9		(180)
white prepupae new		(255)
white prepupae 12hr		(215)
white prepupae 24hr		(211)
pupae 2d postWPP		(146)
pupae 3d postWPP		(48)
pupae 4d postWPP		(39)
adult male 01day		(65)
adult male 05day		(40)
adult male 30day		(48)
adult female 01day		(107)
adult female 05day		(106)
adult female 30day		(118)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		60
embryo 02-04hr		6
embryo 04-06hr		2
embryo 06-08hr		1
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		1
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		5
larva L1		28
larva L2		62
larva L3 12hr old		43
larva L3 puffstage 1-2		22
larva L3 puffstage 3-6		78
larva L3 puffstage 7-9		(180)
white prepupae new		(255)
white prepupae 12hr		(215)
white prepupae 24hr		(211)
pupae 2d postWPP		(146)
pupae 3d postWPP		48
pupae 4d postWPP		39
adult male 01day		65
adult male 05day		40
adult male 30day		48
adult female 01day		107
adult female 05day		106
adult female 30day		(118)
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		60
embryo 02-04hr		6
embryo 04-06hr		2
embryo 06-08hr		1
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		1
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		5
larva L1		28
larva L2		62
larva L3 12hr old		43
larva L3 puffstage 1-2		22
larva L3 puffstage 3-6		78
larva L3 puffstage 7-9		180
white prepupae new		255
white prepupae 12hr		215
white prepupae 24hr		211
pupae 2d postWPP		146
pupae 3d postWPP		48
pupae 4d postWPP		39
adult male 01day		65
adult male 05day		40
adult male 30day		48
adult female 01day		107
adult female 05day		106
adult female 30day		118
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		60
embryo 02-04hr		6
embryo 04-06hr		2
embryo 06-08hr		1
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		1
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		5
larva L1		28
larva L2		62
larva L3 12hr old		43
larva L3 puffstage 1-2		22
larva L3 puffstage 3-6		78
larva L3 puffstage 7-9		180
white prepupae new		255
white prepupae 12hr		215
white prepupae 24hr		211
pupae 2d postWPP		146
pupae 3d postWPP		48
pupae 4d postWPP		39
adult male 01day		65
adult male 05day		40
adult male 30day		48
adult female 01day		107
adult female 05day		106
adult female 30day		118
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(60)
embryo 02-04hr		6
embryo 04-06hr		2
embryo 06-08hr		1
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		1
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		5
larva L1		28
larva L2		(62)
larva L3 12hr old		(43)
larva L3 puffstage 1-2		22
larva L3 puffstage 3-6		(78)
larva L3 puffstage 7-9		(180)
white prepupae new		(255)
white prepupae 12hr		(215)
white prepupae 24hr		(211)
pupae 2d postWPP		(146)
pupae 3d postWPP		(48)
pupae 4d postWPP		(39)
adult male 01day		(65)
adult male 05day		(40)
adult male 30day		(48)
adult female 01day		(107)
adult female 05day		(106)
adult female 30day		(118)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		60
embryo 02-04hr		6
embryo 04-06hr		2
embryo 06-08hr		1
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		1
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		5
larva L1		28
larva L2		62
larva L3 12hr old		43
larva L3 puffstage 1-2		22
larva L3 puffstage 3-6		78
larva L3 puffstage 7-9		(180)
white prepupae new		(255)
white prepupae 12hr		(215)
white prepupae 24hr		(211)
pupae 2d postWPP		(146)
pupae 3d postWPP		48
pupae 4d postWPP		39
adult male 01day		65
adult male 05day		40
adult male 30day		48
adult female 01day		107
adult female 05day		106
adult female 30day		118
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		60
embryo 02-04hr		6
embryo 04-06hr		2
embryo 06-08hr		1
embryo 08-10hr		1
embryo 10-12hr		2
embryo 12-14hr		2
embryo 14-16hr		1
embryo 16-18hr		1
embryo 18-20hr		1
embryo 20-22hr		4
embryo 22-24hr		5
larva L1		28
larva L2		62
larva L3 12hr old		43
larva L3 puffstage 1-2		22
larva L3 puffstage 3-6		78
larva L3 puffstage 7-9		180
white prepupae new		255
white prepupae 12hr		215
white prepupae 24hr		211
pupae 2d postWPP		146
pupae 3d postWPP		48
pupae 4d postWPP		39
adult male 01day		65
adult male 05day		40
adult male 30day		48
adult female 01day		107
adult female 05day		106
adult female 30day		118
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		40
Schneider line 2 Sg4		5
embryonic 1182-4H		26
embryonic GM2		19
embryonic Kc167		4
embryonic S1		9
embryonic S3		12
leg disc CME L1		3
wing disc CME-W2		0
wing disc ML-DmD8		6
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		2
wing disc ML-DmD21		11
wing disc ML-DmD32		3
haltere disc ML-DmD17-c3		41
eye-antennal disc ML-DmD11		2
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		38
tumorous blood cells mbn2		11
ovary fGS/OSS		5
ovary OSC		10
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(40)
Schneider line 2 Sg4		5
embryonic 1182-4H		26
embryonic GM2		19
embryonic Kc167		4
embryonic S1		9
embryonic S3		12
leg disc CME L1		3
wing disc CME-W2		0
wing disc ML-DmD8		6
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		2
wing disc ML-DmD21		11
wing disc ML-DmD32		3
haltere disc ML-DmD17-c3		(41)
eye-antennal disc ML-DmD11		2
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		(38)
tumorous blood cells mbn2		11
ovary fGS/OSS		5
ovary OSC		10
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		40
Schneider line 2 Sg4		5
embryonic 1182-4H		26
embryonic GM2		19
embryonic Kc167		4
embryonic S1		9
embryonic S3		12
leg disc CME L1		3
wing disc CME-W2		0
wing disc ML-DmD8		6
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		2
wing disc ML-DmD21		11
wing disc ML-DmD32		3
haltere disc ML-DmD17-c3		41
eye-antennal disc ML-DmD11		2
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		38
tumorous blood cells mbn2		11
ovary fGS/OSS		5
ovary OSC		10
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		40
Schneider line 2 Sg4		5
embryonic 1182-4H		26
embryonic GM2		19
embryonic Kc167		4
embryonic S1		9
embryonic S3		12
leg disc CME L1		3
wing disc CME-W2		0
wing disc ML-DmD8		6
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		2
wing disc ML-DmD21		11
wing disc ML-DmD32		3
haltere disc ML-DmD17-c3		41
eye-antennal disc ML-DmD11		2
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		38
tumorous blood cells mbn2		11
ovary fGS/OSS		5
ovary OSC		10
ovary OSS		8
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		40
Schneider line 2 Sg4		5
embryonic 1182-4H		26
embryonic GM2		19
embryonic Kc167		4
embryonic S1		9
embryonic S3		12
leg disc CME L1		3
wing disc CME-W2		0
wing disc ML-DmD8		6
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		2
wing disc ML-DmD21		11
wing disc ML-DmD32		3
haltere disc ML-DmD17-c3		41
eye-antennal disc ML-DmD11		2
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		38
tumorous blood cells mbn2		11
ovary fGS/OSS		5
ovary OSC		10
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(40)
Schneider line 2 Sg4		5
embryonic 1182-4H		26
embryonic GM2		19
embryonic Kc167		4
embryonic S1		9
embryonic S3		12
leg disc CME L1		3
wing disc CME-W2		0
wing disc ML-DmD8		6
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		2
wing disc ML-DmD21		11
wing disc ML-DmD32		3
haltere disc ML-DmD17-c3		(41)
eye-antennal disc ML-DmD11		2
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		(38)
tumorous blood cells mbn2		11
ovary fGS/OSS		5
ovary OSC		10
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		40
Schneider line 2 Sg4		5
embryonic 1182-4H		26
embryonic GM2		19
embryonic Kc167		4
embryonic S1		9
embryonic S3		12
leg disc CME L1		3
wing disc CME-W2		0
wing disc ML-DmD8		6
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		2
wing disc ML-DmD21		11
wing disc ML-DmD32		3
haltere disc ML-DmD17-c3		41
eye-antennal disc ML-DmD11		2
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		38
tumorous blood cells mbn2		11
ovary fGS/OSS		5
ovary OSC		10
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		40
Schneider line 2 Sg4		5
embryonic 1182-4H		26
embryonic GM2		19
embryonic Kc167		4
embryonic S1		9
embryonic S3		12
leg disc CME L1		3
wing disc CME-W2		0
wing disc ML-DmD8		6
wing disc ML-DmD9		2
wing disc ML-DmD16-c3		2
wing disc ML-DmD21		11
wing disc ML-DmD32		3
haltere disc ML-DmD17-c3		41
eye-antennal disc ML-DmD11		2
antennal disc ML-DmD20-c5		1
mixed discs ML-DmD4-c1		13
CNS ML-DmBG1-c1		26
CNS ML-DmBG2-c2		38
tumorous blood cells mbn2		11
ovary fGS/OSS		5
ovary OSC		10
ovary OSS		8
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		18
heat shock, 4-day adult		24
Cadmium 50 mM 6 hrs, larvae L3		20
Cadmium 50 mM 12 hrs, larvae L3		43
Cadmium 50 mM 48 hrs, 4-day adult		23
Cadmium 100 mM 48 hrs, 4-day adult		35
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		56
Ethanol 5% 3 hrs, larvae L3		28
Ethanol 10% 3 hrs, larvae L3		17
Caffeine 1.5 mg/ml 4 hrs, larvae L3		12
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		48
Caffeine 25 mg/ml 48 hrs, 4-day adult		16
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		38
Rotenone 2 μg 12 hrs, larvae L3		22
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		18
heat shock, 4-day adult		24
Cadmium 50 mM 6 hrs, larvae L3		20
Cadmium 50 mM 12 hrs, larvae L3		(43)
Cadmium 50 mM 48 hrs, 4-day adult		23
Cadmium 100 mM 48 hrs, 4-day adult		(35)
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		(56)
Ethanol 5% 3 hrs, larvae L3		(28)
Ethanol 10% 3 hrs, larvae L3		17
Caffeine 1.5 mg/ml 4 hrs, larvae L3		12
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(48)
Caffeine 25 mg/ml 48 hrs, 4-day adult		16
Paraquat 5 mM 48 hrs, 4-day adult		(27)
Paraquat 10 mM 48 hrs, 4-day adult		(38)
Rotenone 2 μg 12 hrs, larvae L3		22
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		18
heat shock, 4-day adult		24
Cadmium 50 mM 6 hrs, larvae L3		20
Cadmium 50 mM 12 hrs, larvae L3		43
Cadmium 50 mM 48 hrs, 4-day adult		23
Cadmium 100 mM 48 hrs, 4-day adult		35
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		56
Ethanol 5% 3 hrs, larvae L3		28
Ethanol 10% 3 hrs, larvae L3		17
Caffeine 1.5 mg/ml 4 hrs, larvae L3		12
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		48
Caffeine 25 mg/ml 48 hrs, 4-day adult		16
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		38
Rotenone 2 μg 12 hrs, larvae L3		22
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		18
heat shock, 4-day adult		24
Cadmium 50 mM 6 hrs, larvae L3		20
Cadmium 50 mM 12 hrs, larvae L3		43
Cadmium 50 mM 48 hrs, 4-day adult		23
Cadmium 100 mM 48 hrs, 4-day adult		35
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		56
Ethanol 5% 3 hrs, larvae L3		28
Ethanol 10% 3 hrs, larvae L3		17
Caffeine 1.5 mg/ml 4 hrs, larvae L3		12
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		48
Caffeine 25 mg/ml 48 hrs, 4-day adult		16
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		38
Rotenone 2 μg 12 hrs, larvae L3		22
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		18
heat shock, 4-day adult		24
Cadmium 50 mM 6 hrs, larvae L3		20
Cadmium 50 mM 12 hrs, larvae L3		43
Cadmium 50 mM 48 hrs, 4-day adult		23
Cadmium 100 mM 48 hrs, 4-day adult		35
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		56
Ethanol 5% 3 hrs, larvae L3		28
Ethanol 10% 3 hrs, larvae L3		17
Caffeine 1.5 mg/ml 4 hrs, larvae L3		12
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		48
Caffeine 25 mg/ml 48 hrs, 4-day adult		16
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		38
Rotenone 2 μg 12 hrs, larvae L3		22
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Very low Low Moderate Moderately high High

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		18
heat shock, 4-day adult		24
Cadmium 50 mM 6 hrs, larvae L3		20
Cadmium 50 mM 12 hrs, larvae L3		(43)
Cadmium 50 mM 48 hrs, 4-day adult		23
Cadmium 100 mM 48 hrs, 4-day adult		(35)
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		(56)
Ethanol 5% 3 hrs, larvae L3		28
Ethanol 10% 3 hrs, larvae L3		17
Caffeine 1.5 mg/ml 4 hrs, larvae L3		12
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(48)
Caffeine 25 mg/ml 48 hrs, 4-day adult		16
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		(38)
Rotenone 2 μg 12 hrs, larvae L3		22
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		18
heat shock, 4-day adult		24
Cadmium 50 mM 6 hrs, larvae L3		20
Cadmium 50 mM 12 hrs, larvae L3		43
Cadmium 50 mM 48 hrs, 4-day adult		23
Cadmium 100 mM 48 hrs, 4-day adult		35
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		56
Ethanol 5% 3 hrs, larvae L3		28
Ethanol 10% 3 hrs, larvae L3		17
Caffeine 1.5 mg/ml 4 hrs, larvae L3		12
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		48
Caffeine 25 mg/ml 48 hrs, 4-day adult		16
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		38
Rotenone 2 μg 12 hrs, larvae L3		22
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		22
cold shock, 4-day adult		18
heat shock, 4-day adult		24
Cadmium 50 mM 6 hrs, larvae L3		20
Cadmium 50 mM 12 hrs, larvae L3		43
Cadmium 50 mM 48 hrs, 4-day adult		23
Cadmium 100 mM 48 hrs, 4-day adult		35
Copper 0.5 mM 12 hrs, larvae L3		5
Copper 15 mM 48 hrs, 4-day adult		10
Zinc 5 mM 12 hrs, larvae L3		10
Zinc 4.5 mM 48 hrs, 4-day adult		9
Ethanol 2.5% 3 hrs, larvae L3		56
Ethanol 5% 3 hrs, larvae L3		28
Ethanol 10% 3 hrs, larvae L3		17
Caffeine 1.5 mg/ml 4 hrs, larvae L3		12
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		48
Caffeine 25 mg/ml 48 hrs, 4-day adult		16
Paraquat 5 mM 48 hrs, 4-day adult		27
Paraquat 10 mM 48 hrs, 4-day adult		38
Rotenone 2 μg 12 hrs, larvae L3		22
Rotenone 8 μg 12 hrs, larvae L3		15
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010)

mE2_34_mRNA_expression_cluster_02

External Data & Images

Linkouts

BDGP expression data

•

GM02605

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0014427

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG11899-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable, with Scer\GAL4^pnr-MD237

CG11899^GD7426

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of CG11899	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Allele of CG11899	Class	Mutagen	Stocks	Known lesion
CG11899^GD7426		in vitro construct - RNAi in vitro construct - regulatory fusion	3	Yes
CG11899^KK102855		in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD7426}

P{KK102855}

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 4 terms )

Molecular Function

CV term

Evidence

References

O-phospho-L-serine:2-oxoglutarate aminotransferase activity

inferred from electronic annotation with InterPro:IPR022278

(FlyBase Curators et al., 2004-)

inferred from sequence or structural similarity

(EDGP Project Members, 1994-)

non-traceable author statement

(Swiss-Prot Project Members, 2000.10.1)

pyridoxal phosphate binding

inferred from electronic annotation with InterPro:IPR015421, InterPro:IPR015422

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

L-serine biosynthetic process

inferred from electronic annotation with InterPro:IPR003248

(FlyBase Curators et al., 2004-)

non-traceable author statement

(Swiss-Prot Project Members, 2000.10.1)

pyridoxine biosynthetic process

non-traceable author statement

(Swiss-Prot Project Members, 2000.10.1)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

CG11899 allele

Gene

References

External Data

Linkouts

BioGRID - A database of protein and genetic interactions

•

70214

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0014427

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

46391

Orthologs

OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6PNZ2W

Dipteran inclusive ortholog search

EOG6H9XV6

Insect inclusive ortholog search

EOG6NZSPX

Arthropod inclusive ortholog search

EOG63FFCH

Metazoa inclusive ortholog search

EOG6PCPKW

Orthologs in Drosophila Species (EOG6PNZ2W)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA11267

Drosophila persimilis

Dper\GL13880

Drosophila willistoni

Dwil\GK22671

Drosophila virilis

Dvir\GJ14513

Drosophila mojavensis

Dmoj\GI10400

Drosophila grimshawi

Dgri\GH14302

Orthologs in non-Drosophila Dipterans (EOG6H9XV6)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL012578

Anopheles gambiae

Malaria mosquito

Agam\AGAP004598

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ008287

Orthologs in non-Dipteran Insects (EOG6NZSPX)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\LOC412670

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG011657

Atta cephalotes

Leafcutter ant

Acep\ACEP26804

Atta cephalotes

Leafcutter ant

Acep\ACEP26800

Camponotus floridanus

Florida carpenter ant

Cflo\serC

Harpegnathos saltator

Jerdons jumping ant

Hsal\serC

Linepithema humile

Argentine ant

Lhum\LH19625

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB18005

Solenopsis invicta

Red fire ant

Sinv\SINV10584

Solenopsis invicta

Red fire ant

Sinv\SINV10590

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004666

Bombyx mori

Silkmoth

Bmor\BGIBMGA012485

Pediculus humanus

Human body louse

Phum\PHUM522250

Tribolium castaneum

Red flour beetle

Tcas\TC000542

Orthologs in non-Insect Arthropods (EOG63FFCH)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\serC

Ixodes scapularis

Deer tick

Isca\ISCW020198

Orthologs in non-Arthropod Metazoa (EOG6PCPKW)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\F26H9.5

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_008652gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_020138gn

Danio rerio

Zebrafish

Drer\psat1

Xenopus tropicalis

Western clawed frog

Xtro\psat1

Gallus gallus

Domestic chicken

Ggal\PSAT1

Mus musculus

House mouse

Mmus\Psat1

Rattus norvegicus

Norway rat

Rnor\Psat1

Homo sapiens

Human

Hsap\ENSG00000135069

Human Orthologs (1)

Gene

OMIM

HGNC

Hsap\ENSG00000135069

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA11267

Drosophila persimilis

Dper\GL13880

Drosophila willistoni

Dwil\GK22671

Drosophila virilis

Dvir\GJ14513

Drosophila mojavensis

Dmoj\GI10400

Drosophila grimshawi

Dgri\GH14302

Stocks & Reagents

Stocks Listed in FlyBase ( 4 )

VDRC

v103936

P{KK102855}VIE-260B

v16360

w¹¹¹⁸; P{GD7426}v16360/TM3

v43549

w¹¹¹⁸; P{GD7426}v43549/CyO

v43551

w¹¹¹⁸; P{GD7426}v43551/CyO

Genomic Clones ( 1 )

BACR22E21

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 64 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones