Open Close
General Information
Symbol
Scer\FLP1
Species
S. cerevisiae
Name
FLIP recombinase
Annotation Symbol
Feature Type
FlyBase ID
FBgn0014444
Gene Model Status
Stock Availability
Also Known As

FLP, FLP1

Tag or Foreign Gene Data

Foreign sequence; species == Saccharomyces cerevisiae; gene == FLP1; SGD:S000029654.

Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Molecular Function (GO)
    [Detailed GO annotations]
    Experimental Evidence
    -
    Predictions / Assertions
    -
    Summaries
    Gene Model and Products
    Number of Transcripts
    0
    Number of Unique Polypeptides
    0
    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Comments on Gene Model
    Sequence Ontology: Class of Gene
    Transcript Data
    Annotated Transcripts
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Polypeptides with Identical Sequences

     

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Nucleotide / Polypeptide Records
      Mapped Features

      Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Scer\FLP1 using the Feature Mapper tool.

      External Data
      Crossreferences
      Linkouts
      Gene Ontology (0 terms)
      Molecular Function (0 terms)
      Terms Based on Experimental Evidence (0 terms)
      Terms Based on Predictions or Assertions (0 terms)
      Biological Process (0 terms)
      Terms Based on Experimental Evidence (0 terms)
      Terms Based on Predictions or Assertions (0 terms)
      Cellular Component (0 terms)
      Terms Based on Experimental Evidence (0 terms)
      Terms Based on Predictions or Assertions (0 terms)
      Expression Data
      Expression Summary Ribbons
      Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
      For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
      Transcript Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Polypeptide Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Evidence
      References
      Expression Deduced from Reporters
      High-Throughput Expression Data
      Associated Tools

      GBrowse - Visual display of RNA-Seq signals

      View Scer\FLP1 in GBrowse 2
      RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
      Reference
      See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
      Developmental Proteome: Life Cycle
      Developmental Proteome: Embryogenesis
      External Data and Images
      Alleles, Insertions, and Transgenic Constructs
      Classical and Insertion Alleles ( 36 )
      For All Classical and Insertion Alleles Show
       
      Other relevant insertions
      Transgenic Constructs ( 109 )
      For All Alleles Carried on Transgenic Constructs Show
      Transgenic constructs containing/affecting coding region of Scer\FLP1
      Transgenic constructs containing regulatory region of Scer\FLP1
      Deletions and Duplications ( 0 )
      Phenotypes
      For more details about a specific phenotype click on the relevant allele symbol.
      Lethality
      Allele
      Sterility
      Allele
      Other Phenotypes
      Allele
      Phenotype manifest in
      Allele
      Orthologs
      Human Orthologs (via DIOPT v7.1)
      Homo sapiens (Human) (0)
      No records found.
      Model Organism Orthologs (via DIOPT v7.1)
      Drosophila melanogaster (Fruit fly) (0)
      No records found.
      Ortholog(s) in Drosophila melanogaster (via OrthoDB v9.1) ( None identified )
      No D. melanogaster orthologies identified
      Human Disease Associations
      FlyBase Human Disease Model Reports
        Disease Model Summary Ribbon
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Evidence
        References
        Potential Models Based on Orthology ( 0 )
        Human Ortholog
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Interaction
        References
        Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
        Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
        Homo sapiens (Human)
        Gene name
        Score
        OMIM
        OMIM Phenotype
        DO term
        Complementation?
        Transgene?
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        Recombination map
        Cytogenetic map
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (3,293)
        Genomic Clones (0)
         
          cDNA Clones (0)
           

          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

          cDNA clones, fully sequences
          BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                cDNA Clones, End Sequenced (ESTs)
                BDGP DGC clones
                  Other clones
                    RNAi and Array Information
                    Linkouts
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of
                    Source for database merge of
                    Additional comments
                    Other Comments

                    Scer\FRT-site insertion in third chromosome can influence second chromosome nondisjunction. The phenomenon demonstrates the behaviour of different pairs of homologous chromosomes in male meiosis are not independent.

                    The Scer\FLP1-Scer\FRT site-specific recombination system can be used to integrate DNA at a chromosomal Scer\FRT target site. Events are recovered using a w reporter gene.

                    The w+mW.hs mutation carried in the P{FRT(whs)} element can be excised from its site of integration by the induction of Scer\FLP1 synthesis. Scer\FLP1 can be used to excise an Scer\FRT-flanked gene after cell division has ceased and the gene, now present on an extrachromosomal circle, is expressed. Most position effects are reverted by the removal of this gene from the chromosome.

                    The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to study the zygotic lethal mutation.

                    A method that uses Cbβ\DT-A, the Scer\FLP1 recognition target sequences and the Scer\GAL4-Scer\UAS activation system can be used to ablate specific neurons in the embryo and to examine the consequences.

                    Clonal analysis has been used to characterise the somatic stem cells that give rise to ovarian follicle cells.

                    Scer\FLP1 recombinase can promote mitotic exchange during embryonic development.

                    Origin and Etymology
                    Discoverer
                    Etymology
                    Identification
                    External Crossreferences and Linkouts ( 1 )
                    Other crossreferences
                    SGD - Saccharomyces Genome Database
                    Synonyms and Secondary IDs (14)
                    Reported As
                    Symbol Synonym
                    FLIP
                    FLP
                    (Cook, 2017.12.20, Awasaki et al., 2014, Awasaki et al., 2014, Awasaki et al., 2014, Chen and Krasnow, 2014, Chen and Zipursky, 2014.4.17, Gambetta and Müller, 2014, Gurudev et al., 2014, Aoyama et al., 2013, Fregoso Lomas et al., 2013, Greer et al., 2013, Jukam et al., 2013, Rousso et al., 2013, Gault et al., 2012, Moraru et al., 2012, Singh and Mlodzik, 2012, Zhang et al., 2012, Awasaki et al., 2011, Jenny, 2011, Leonardi et al., 2011, Molnar et al., 2011, Nern et al., 2011, Poulton et al., 2011, Roy et al., 2011, Stephan et al., 2011, Thum et al., 2011, Biehs et al., 2010, Cheng et al., 2010, Das Thakur et al., 2010, Elsaesser et al., 2010, Erokhin et al., 2010, Grönke et al., 2010, Gurudatta et al., 2010, Haruta et al., 2010, Herranz et al., 2010, Hudson and Cooley, 2010, Krivega et al., 2010, Monastirioti et al., 2010, Portela et al., 2010, Potter et al., 2010, Richardson and Pichaud, 2010, Roch et al., 2010, Silicheva et al., 2010, Swaminathan and Pile, 2010, Tsuda et al., 2010, Zheng et al., 2010, Bhattacharya and Baker, 2009, Choi et al., 2009, Patel et al., 2009, Awasaki et al., 2008, Berger et al., 2008, Bazigou et al., 2007, Bazigou et al., 2007, Hattori et al., 2007, Kracklauer et al., 2007, Millard et al., 2007, Millard et al., 2007, Rakovitsky et al., 2007, Song et al., 2007, Hofmeyer et al., 2006, LaLonde et al., 2006, Schimmelpfeng et al., 2006, Wernet et al., 2006, Djiane et al., 2005, Hiesinger et al., 2005, Mehta et al., 2005, Vaccari and Bilder, 2005, Wittwer et al., 2005, Chew et al., 2004, Komiyama et al., 2004, Lawrence et al., 2004, Ratnakumar and Desplan, 2004.3, Leismann and Lehner, 2003, Carroll et al., 2002, Clandinin et al., 2001, Maurel-Zaffran et al., 2001, Maurel-Zaffran and Treisman, 2000, Newsome et al., 2000, Tanentzapf et al., 2000, Luo et al., 1999, Percival-Smith and Bondy, 1999, Ahmad and Golic, 1998, Bellotto et al., 1998, Chen et al., 1998, Marin et al., 1998, Perrimon, 1998, Platero and Henikoff, 1998, Beumer, 1997.3.10, de Celis, 1997, Gorfinkiel et al., 1997, Kosman and Small, 1997, Mullor et al., 1997, Yang et al., 1997, Chou and Perrimon, 1996, Frise et al., 1996)
                    Scer\FLP1
                    Name Synonyms
                    FLIP recombinase
                    Flp DNA recombinase
                    Flp recombinase
                    Secondary FlyBase IDs
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      References (588)