Gene Dmel\17.6\pol

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General Information

Symbol

Dmel\17.6\pol

Species

D. melanogaster

Name

17.6 element transposase

Annotation symbol

Feature type

transposable_element_gene

FlyBase ID

FBgn0014453

Created / Updated

2006-08-20/2007-09-12

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

Sequence location

Summary Information

Automatically generated summary

See sections below for more information

The gene 17.6 element transposase is referred to in FlyBase by the symbol 17.6\pol (FBgn0014453). It has not been localized to the genome sequence. Its molecular function is described as: RNA-directed DNA polymerase activity; RNA binding; DNA binding; aspartic-type endopeptidase activity. It is involved in the biological processes: RNA-dependent DNA replication; proteolysis; DNA integration. No alleles are reported. It has no annotated transcripts.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

RNA-directed DNA polymerase (reverse transcriptase) (IPR000477)

Integrase, catalytic core (IPR001584)

Peptidase aspartic, active site (IPR001969)

Peptidase A2A, retrovirus, catalytic (IPR001995)

Peptidase aspartic, catalytic (IPR009007)

Polynucleotidyl transferase, Ribonuclease H fold (IPR012337)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

X01472

CAA25702

UniProtKB/Swiss-Prot

P04323

UniProtKB/TrEMBL

Maps to

Does NOT map to

Identified with

Mapped Features & Mutations

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of 17.6\pol	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of 17.6\pol	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Gene Ontology: Function, Process & Cellular Component ( 7 )

Molecular Function

CV term

Evidence

References

DNA binding

inferred from electronic annotation with InterPro:IPR001584

(FlyBase Curators et al., 2004-)

RNA binding

inferred from electronic annotation with InterPro:IPR000477

(FlyBase Curators et al., 2004-)

RNA-directed DNA polymerase activity

inferred from electronic annotation with InterPro:IPR000477

(FlyBase Curators et al., 2004-)

aspartic-type endopeptidase activity

inferred from electronic annotation with InterPro:IPR001969, InterPro:IPR001995, InterPro:IPR009007

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

DNA integration

inferred from electronic annotation with InterPro:IPR001584

(FlyBase Curators et al., 2004-)

RNA-dependent DNA replication

inferred from electronic annotation with InterPro:IPR000477

(FlyBase Curators et al., 2004-)

proteolysis

inferred from electronic annotation with InterPro:IPR001969, InterPro:IPR001995, InterPro:IPR009007

(FlyBase Curators et al., 2004-)

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

transposable_element_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

17.6\pol allele

Gene

References

External Data

Linkouts

Orthologs

Genome-wide drosophilid orthologs

Curated drosophilid orthologs

Linkouts

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 0 )

Genomic Clones ( 0 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

Antibody Information

Other Information

Discoverer

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Encoded by

17.6

Additional comments

Comments About Role

The transposase encoded by the 17.6 element.

The regulation of transcription of the 17.6 retrotransposon provides a model for the study of innervation-dependent gene expression in postsynaptic cells during neurogenesis.

(Mozer and Benzer, 1994)

Comments About Molecular Function

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

DDBJ / EMBL / GenBank

•

UniProtKB/Swiss-Prot

•

P04323

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

RNA-directed DNA polymerase (reverse transcriptase) (IPR000477)

Integrase, catalytic core (IPR001584)

Peptidase aspartic, active site (IPR001969)

Peptidase A2A, retrovirus, catalytic (IPR001995)

Peptidase aspartic, catalytic (IPR009007)

Polynucleotidyl transferase, Ribonuclease H fold (IPR012337)

Linkouts

Synonyms & Secondary IDs ( 3 )

Reported As

Symbol Synonym

17.6\pol

17.6\T

Name Synonym

17.6 element transposase

(Mozer and Benzer, 1994)

Secondary FlyBase IDs

References ( 4 )

Research paper

Desset et al., 1999, Molec. Biol. Evol. 16(1): 54--66: Mobilization of two retroelements, ZAM and Idefix, in a novel unstable line of Drosophila melanogaster. [FBrf0106414]
Lerat and Capy, 1999, Molec. Biol. Evol. 16(9): 1198--1207: Retrotransposons and retroviruses: analysis of the envelope gene. [FBrf0111944]
Mozer and Benzer, 1994, Development 120(5): 1049--1058: Ingrowth by photoreceptor axons induces transcription of a retrotransposon in the developing Drosophila brain. [FBrf0073975]

Personal communication to FlyBase

FlyBase Curators et al., 2004-, Gene Ontology annotation in FlyBase through association of InterPro records with GO terms.: Gene Ontology annotation in FlyBase through association of InterPro records with GO terms. [FBrf0174215]